CN106668060A - Anti-cancer preparation containing sulforaphane and selenium and preparation method thereof - Google Patents
Anti-cancer preparation containing sulforaphane and selenium and preparation method thereof Download PDFInfo
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- CN106668060A CN106668060A CN201710047181.7A CN201710047181A CN106668060A CN 106668060 A CN106668060 A CN 106668060A CN 201710047181 A CN201710047181 A CN 201710047181A CN 106668060 A CN106668060 A CN 106668060A
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- curcumin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
Abstract
The invention discloses an anti-cancer preparation containing sulforaphane and selenium. The anti-cancer preparation is prepared from the following components in parts by weight: 30 to 144 parts of the sulforaphane and 6 to 60 parts of the selenium, and the anti-cancer preparation further comprises 0 to 10 parts of resveratrol, 0 to 300 parts of EGCG (Epigallocatechin Gallate), 0 to 200 parts of curcumin and auxiliary materials. As the second aim of the invention, the invention further discloses a preparation method of the anti-cancer preparation. A healthy health-care preparation is formed through mixing the sulforaphane, the selenium, the resveratrol, the EGCG, the curcumin and the like, and has very good capabilities of resisting oxidization, removing in-vivo free radicals, activating Nrf2 channels, and recovering functions of distinguishing and swallowing bacteria of macrophages; the anti-cancer preparation can be used for inhibiting the reproduction of cancer cells and especially has very good assisting health-care and treatment functions on lung cancer and liver cancer.
Description
Technical field
The present invention relates to the technical field of anticancer complex prescription, and in particular to a kind of anticancer system containing sulforaphen and selenium
Agent.
Background technology
Sulforaphen, also known as Sulforaphane, English name is Sulforaphane, CAS 4478-93-7, molecular formula
C6H11NOS2, molecular weight 177.30.Sulforaphen is a kind of isothiocyanic acid esters compound, 1992 first by U.S. John-
John Hopkins University's research worker finds (Proceedings of the National Academy of from broccoli sprouting
Sciences,USA.1992,89:2399-2403).This compound exists in other brassicaceous vegetables, such as cabbage mustard,
In Chinese cabbage, cauliflower, root-mustard, Caulis et Folium Brassicae junceae, Radix Raphani and green water cress etc., usually with the presence of glucosinolate form.When plant is broken
When bad (such as chewing), glucosinolate is converted into effective ingredient sulforaphen by Inner sources myrosinase.Broccoli seed and
In the tender shoots of Caulis et Folium Brassicae capitatae, the content of glucosinolate is especially enriched.
Sulforaphen is the activity most best molecule of strong, effect in all natural anti-cancer materials having now been found that, or even can
So that tumor regression.Sulforaphen can activate a kind of signalling channel of entitled Nrf2 (NF-E2-related factor-2), to pierce
The redox ability of sharp cell.This signalling channel once can not play a role, human macrophages just cannot normal work,
Some organs of human body will be damaged.
Selenium element is trace mineral nutrient needed by human, and the selenium total content of human body itself is 6~20mg.Selenium is food
Thing source antioxidant, can remove oxygen-derived free radicals excessive in human body, prevent the snperoxiaized destruction of Cell membrane lipids, its anti-freedom
Base effect is Vitamin E and ascorbic 300~500 times.More than 40 kinds of disease is relevant with the scarce selenium of human body, such as cancer, cardiovascular
The diseases such as disease, hepatopathy, cataract, pancreatic disease, diabetes, reproductive system, and during selenium deficiency, it is easy to cause human immunity
Ability declines, but there is no the organ of Long-term Storage selenium in human body, therefore the selenium needed for body needs constantly to obtain from diet
To supplement.
Resveratrol is polyphenol compound, is mainly derived from the plants such as Semen arachidis hypogaeae, Fructus Vitis viniferae, Rhizoma Polygoni Cuspidati, Fructus Mori.Resveratrol is
A kind of very strong natural polyphenol class material of biological activity, is also called resvertrol, is the chemopreventive agent of tumor, is also to reducing blood
Platelet is assembled, prevention and treatment atherosclerosiss, the chemopreventive agent of cardiovascular and cerebrovascular disease.Meanwhile, resveratrol can be very
Suppress human body chromosome two ends telomerase activation well, so as to extend human life-span.
EGCG is epigallocatechin gallate (EGCG), is one of maximally effective active component in tea polyphenols, is belonged to
Theine.EGCG has antibacterial, antiviral, antioxidation, arteriosclerosis, antithrombus formation, antiangiogenic, antiinflammatory and removing
Free radical, antitumor action.
Curcumin be some plants from Zingiberaceae, Araeceae rhizome in extract a kind of chemical composition, wherein, Rhizoma Zingiberis Recens
Huang, containing about 3%~6%, is the very rare pigment with diketone of plant kingdom, is cyclohexadione compounds.Curcumin is orange-yellow knot
Crystalline flour end, taste is slightly bitter.It is water insoluble.Medical research shows that curcumin has blood fat reducing, antitumor, antiinflammatory, function of gallbladder promoting, antioxidation
Deng effect.
The content of the invention
Goal of the invention：The invention aims to make up the deficiency of existing investigative technique, there is provided one kind has fine
Antioxidation and anticancer increase function anticancer preparation.
Technical scheme：A kind of anticancer preparation, including each component of following parts by weight：Sulforaphen 30-144 parts, selenium 6-60
Part.
Preferably, one or more of resveratrol 0-10 parts, EGCG 0-300 parts, curcumin 0-200 parts.
Preferably, also including adjuvant.
Preferably, described adjuvant is at least one in filler, disintegrating agent.
Preferably, described anticancer preparation is tablet, granule, capsule, soft capsule.
The invention also discloses the preparation method of above-mentioned anticancer preparation, comprises the following steps：
1) sulforaphen, selenium, resveratrol, EGCG, curcumin and adjuvant are mixed according to above-mentioned deal；
2) by step 1) in the product vacuum that obtains dry, pulverize 40 mesh sieves, obtain mixture；
3) by step 2) the mixture tabletting that obtains or granulation or fill capsule；
4) packaging, inspection, warehouse-in.
The present invention is by by the mixing such as sulforaphen, selenium, resveratrol, EGCG, curcumin, forming health care preparation, tool
There is good antioxidation, remove interior free yl, activation Nrf2 passages, recover the ability that macrophage is differentiated and swallows antibacterial,
And being capable of anticancer growth；And with anti-inflammatory properties, the infringement that haze brings to alveolar can be repaired, therefore the present invention is outstanding
It has good health-care assistance to pulmonary carcinoma and hepatocarcinoma and controls treatment functions.
Specific embodiment：
In the present invention, sulforaphen, selenium, resveratrol, EGCG, curcumin are commercially available.
Embodiment 1：A kind of anticancer preparation, including each component of following parts by weight：30 parts of sulforaphen, 60 parts of selenium, Hard Fat
Sour magnesium 1-2 parts.
The preparation method of above-mentioned anticancer preparation, comprises the following steps：
1) sulforaphen, selenium, magnesium stearate are mixed according to above-mentioned deal；
2) by step 1) in the product vacuum that obtains be dried, cross 40 mesh sieves, obtain mixture；
3) by step 2) in the mixture tabletting that obtains；
4) packaging, inspection, warehouse-in.
Embodiment 2：A kind of anticancer preparation, including each component of following parts by weight：30 parts of sulforaphen, 6 parts of selenium,
150 parts of EGCG150 parts, curcumin, adjuvant be 15 parts of starch, 10 parts of magnesium stearate.
The preparation method of above-mentioned anticancer preparation, comprises the following steps：
1) sulforaphen, selenium, EGCG, curcumin, starch, magnesium stearate are mixed according to above-mentioned deal；
2) by step 1) in the product vacuum that obtains be dried, cross 40 mesh sieves, obtain mixture；
3) by step 2) in the mixture tabletting that obtains；
4) packaging, inspection, warehouse-in.
Embodiment 3：
A kind of anticancer preparation, including each component of following parts by weight：144 parts of sulforaphen, 60 parts of selenium, resveratrol 10
Part, 300 parts of EGCG, 200 parts of curcumin, adjuvant be dextrin 10-12 parts, 1 part of magnesium stearate.
Anticancer preparation is granule.
The preparation method of above-mentioned anticancer preparation, comprises the following steps：
1) sulforaphen, selenium, resveratrol, EGCG, curcumin, dextrin, magnesium stearate are mixed according to above-mentioned deal；
2) by step 1) in the product vacuum that obtains dry, pulverize, cross 40 mesh sieves, obtain mixture；
3) by step 2) mixture that obtains pelletized by granulator；
4) packaging, inspection, warehouse-in.
Embodiment 4：
A kind of anticancer preparation, including each component of following parts by weight：144 parts of sulforaphen, 60 parts of selenium, adjuvant are plant
Oily 20 parts, 3 parts of gelatin.Anticancer preparation is capsule, soft capsule.
The preparation method of above-mentioned anticancer preparation, comprises the following steps：
1) sulforaphen, selenium, vegetable oil, gelatin are mixed according to above-mentioned deal, is pelletized by granulator；
2) by step 1) in the product vacuum that obtains be dried, cross 40 mesh sieves, obtain mixture；
3) by step 2) mixture that obtains dress capsule is capsule.
Embodiment 5：
A kind of anticancer preparation, including each component of following parts by weight：100 parts of sulforaphen, 30 parts of selenium, resveratrol 8
Part, 150 parts of EGCG, 150 parts of curcumin, adjuvant be 20 parts of starch, 1 part of magnesium stearate.
The preparation method of above-mentioned anticancer preparation, comprises the following steps：
1) by sulforaphen, selenium, resveratrol, EGCG, curcumin, starch, magnesium stearate mixes according to above-mentioned deal；
2) by step 1) in the product vacuum that obtains dry, pulverize, cross 40 mesh sieves, obtain mixture；
3) by step 2) in the mixture tabletting that obtains；
4) packaging, inspection, warehouse-in.
In order to further embody the beneficial effect of the application, spy provides following test example：
The human experimentation clinical therapeutic efficacy of this product：It is various as ancillary drug and operative treatment observation by the use of this product
Malignant tumor 153, wherein male 82, women 71, oldest 72 years old, minimum 33 years old, wherein pulmonary carcinoma 21, liver
Cancer 18, mammary cancer 18, carcinoma of prostate 15, gastric cancer 12, rectal cancer 11, nasopharyngeal carcinoma 10, esophageal carcinoma 15, lymph
Cancer 8, cancer of pancreas 8, cerebral glioma 7,5 Cases of Leukemia, depression 5.Therapeutic effect such as table 1 below：
Wherein, healing, clinical cure, effective, invalid criterion of therapeutical effect be by《Chinese common cancer treats specification》
In treatment malignant tumor efficacy assessment standard comprehensively evaluated.
Cure：Symptom and objective determination positive classification disappear Jing after treatment, Jing imaging examination tumor disappearances, recover certain
Labour force, Continuous Observation more than 3 years is without recidivist.
Clinical cure：Check tumor regression half or it is general more than, recover certain labour force, Continuous Observation half a year to one
Year, above person was without recidivist；
Table 1
It is effective：Jing after treatment, cardinal symptom and objective positive sign are clearly better, Jing imaging examinations tumor stabilisation or bright
It is aobvious to reduce, the not developing deeply person of Continuous Observation 26 months.
It is invalid：Cardinal symptom and objective determination positive sign improve without improvement or only short-term and deteriorate rapidly Jing after treatment
Person.
153 malignant tumor patients of the above, treatment can rapidly improve symptom in 3 months, increase appetite, it is observed that swollen
It is 52 days that block reduces time average.
Case 1：Patient Lee women, 62 years old, Jiangsu people from Qidong went to a doctor on 2 16th, 2015, and patient is before 10 days in Jiangsu
Institute of traditional Chinese medicine of province is diagnosed as pulmonary carcinoma, pulmonary shadow size 50mm*40mm, 30mm*20mm, and outside patient's cough, patient is also
Have the symptoms such as expectorant, sputum mixed with blood, chest pain.This product cooperation Drug therapy is checked shade and is almost disappeared after 3 months, cough, chest pain
It has been obviously improved etc. symptom, has continued to strengthen 3 months, checked after half a year, indices is completely normal.
Case 2：Patient Huang, male, 59 years old, Jiangsu people from Qidong was diagnosed as liver cirrhosis, hepatic ascites regulating liver-QI before three months
Cancer.Once interventional therapy, DeGrain were given in infectious hospital.Aggravation, weak, oliguria, abdominal distention.In in June, 2015
Start within 13rd auxiliary carries out anticancer therapy using this product.Ascites disappears after 3 months, lump is checked after 5 months and is substantially disappeared, invariably
After suitable symptom, follow-up 1 year, patient is in a good state of health at present.
Case 3：Patient Lv women, Yancheng, Jiangsu Province people 44 years old, in May, 2015, feels distending pain of the breast often, has
Caking, June 18 is diagnosed as breast carcinoma.Using this product, with reference to treatment by Chinese herbs, after 3 months, lump substantially softens, diminishes, image
Check mass reduction, every biochemical indicator tends to normal, persistently using half a year after, return to normal, this product is taken always, extremely
It is modern healthy.
Case 2：Patient talks certain, male, 73 years old, Heze City, Shandong Province people, and August is gone to a doctor on the 13rd within 2014, and patient felt before one month
Feel uncomfortable, abdominal pain, go the enteral spectroscopy of hospital admission to be diagnosed as rectal cancer 20*30mm cauliflower like masses, due to suffering from
Person's body constitution is bad, physical weakness, does not carry out operative treatment, allows it to take treating cancer medicine, and aids in this product to treat, 6 months
Afterwards enteroscopy focus is obviously reduced, and sense of discomfort is completely without patient is healthy so far.
Shown by above-mentioned test example, the made preparation of the present invention, with good antioxidation, remove interior free yl,
Activation Nrf2 passages, recover macrophage differentiate and swallow antibacterial ability, and can anticancer increase, especially to lung
Cancer, hepatocarcinoma, breast carcinoma and gastric cancer have significant curative effect.
Claims (6)
1. a kind of anticancer preparation containing sulforaphen and selenium, it is characterised in that：Including each component of following parts by weight：Radix Raphani sulfur
Plain 30-144 parts, selenium 6-60 parts.
2. the anticancer preparation containing sulforaphen and selenium as claimed in claim 1, it is characterised in that：Also include following weight portion
Several each components：One or more in resveratrol 0-10 parts, EGCG 0-300 parts, curcumin 0-200 parts.
3. anticancer preparation as claimed in claim 1 or 2, it is characterised in that：Also include adjuvant.
4. anticancer preparation as claimed in claim 3, it is characterised in that：Described adjuvant be filler, disintegrating agent at least
It is a kind of.
5. anticancer preparation as claimed in claim 3, it is characterised in that：Described anticancer preparation is tablet, granule, capsule
Agent, soft capsule.
6. the preparation method of the anticancer preparation as described in claim 1-5, it is characterised in that：Comprise the following steps：
1) sulforaphen, selenium, resveratrol, EGCG, curcumin and adjuvant are mixed according to above-mentioned deal；
2) by step 1) in the product vacuum that obtains dry, pulverize, cross 40 mesh sieves, obtain mixture；
3) by step 2) in the mixture tabletting that obtains or granulation or fill capsule or soft capsule processed；
4) packaging, inspection, warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710047181.7A CN106668060A (en) | 2017-01-22 | 2017-01-22 | Anti-cancer preparation containing sulforaphane and selenium and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201710047181.7A CN106668060A (en) | 2017-01-22 | 2017-01-22 | Anti-cancer preparation containing sulforaphane and selenium and preparation method thereof |
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Family
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| CN201710047181.7A Pending CN106668060A (en) | 2017-01-22 | 2017-01-22 | Anti-cancer preparation containing sulforaphane and selenium and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272780A (en) * | 2018-04-08 | 2018-07-13 | 大连元固康健科技有限公司 | It is a kind of that there is the composition for inhibiting hepatoma cell proliferation effect and its application |
| CN108925992A (en) * | 2018-08-08 | 2018-12-04 | 林向阳 | Protect liver supports lung, health food of runchang detoxification and preparation method thereof |
| PL426791A1 (en) * | 2018-08-27 | 2019-08-12 | Narodowy Instytut Leków | Conjugates of selenium and isocyanate nanoparticles for application in treatment of tumors |
Citations (2)
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| CN103263464A (en) * | 2013-04-16 | 2013-08-28 | 阚兆云 | Traditional Chinese medicine extract and preparation method thereof |
| CN105942507A (en) * | 2016-05-23 | 2016-09-21 | 福建农林大学 | Full-nutrition composition with anti-tumor function and tumor suppression function and preparation method of full-nutrition composition |
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2017
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263464A (en) * | 2013-04-16 | 2013-08-28 | 阚兆云 | Traditional Chinese medicine extract and preparation method thereof |
| CN105942507A (en) * | 2016-05-23 | 2016-09-21 | 福建农林大学 | Full-nutrition composition with anti-tumor function and tumor suppression function and preparation method of full-nutrition composition |
Non-Patent Citations (1)
| Title |
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| 林俊城，等: "青花菜硫、硒代谢竞争及其对保健功能的影响研究进展", 《中国细胞生物学学报》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108272780A (en) * | 2018-04-08 | 2018-07-13 | 大连元固康健科技有限公司 | It is a kind of that there is the composition for inhibiting hepatoma cell proliferation effect and its application |
| CN108925992A (en) * | 2018-08-08 | 2018-12-04 | 林向阳 | Protect liver supports lung, health food of runchang detoxification and preparation method thereof |
| PL426791A1 (en) * | 2018-08-27 | 2019-08-12 | Narodowy Instytut Leków | Conjugates of selenium and isocyanate nanoparticles for application in treatment of tumors |
| WO2020046153A1 (en) * | 2018-08-27 | 2020-03-05 | Narodowy Instytut Leków W Warszawie | Conjugates of selenium and isothiocyanate nanoparticles for use in the treatment of tumors |
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Application publication date: 20170517 |