CN100391505C - Medicine for treating esophagus cancer and cardia cancer and its prepn. method - Google Patents
Medicine for treating esophagus cancer and cardia cancer and its prepn. method Download PDFInfo
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- CN100391505C CN100391505C CNB2005100153686A CN200510015368A CN100391505C CN 100391505 C CN100391505 C CN 100391505C CN B2005100153686 A CNB2005100153686 A CN B2005100153686A CN 200510015368 A CN200510015368 A CN 200510015368A CN 100391505 C CN100391505 C CN 100391505C
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Abstract
A Chinese medicine for treating esophagus cancer and cardia cancer is prepared from 10 Chinese-medicinal materials including toad, astragalus root, ginseng, ground beetle, etc. Its preparing process is also disclosed.
Description
Affiliated technical field
The present invention relates to a kind of medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia, is the Chinese patent medicine of feedstock production with the Chinese herbal medicine specifically, the invention still further relates to the preparation method of this medicine.
Background technology
Esophageal carcinoma, carcinoma of gastric cardia are Clinical symptoms with carrying out property dysphagia, character is one of malignant tumor, and histopathology is thought: the form that cancerous cell acts on esophageal lumen is due to intestine erosion and ulcer and the narrow sample change of spot, and the moon of trouble is surplus then with a haggard face, wasting, skin is dry, thereupon cancer poison lymph metastasis and climing and liver lung causes the internal organs material injury at once, critical patient's life, be difficult to treatment, so cancer is the heat subject of the world numerous doctor family research.
Summary of the invention
Purpose of the present invention just provides a kind of medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia, this medical instrument has the detumescence of drawing out pus by applying a plaster to the affected part, set upright to increase and exempt from, the removing blood stasis with potent drugs softening the hard mass, widen narrow effect, by strengthening the immunocompetence of self, eliminates and the antagonism cancerous cell, alleviate patient's misery, prolong patient's life.
Solution of the present invention is based on Chinese medicine to the mechanism of esophageal carcinoma, carcinoma of gastric cardia understanding and Therapeutic Principle, by the medicine compatibility method preparation of " monarch, minister, help, make ".
Medicine of the present invention is made (weight portion) by following component:
Bufo siccus 25-45, Gekko Swinhonis 30-40, Fructus Camptothecae Acuminatae 40-60, Rhizoma Paridis 20-40, Radix Astragali 60-100, Radix Ginseng 20-40, eupolyphaga 30-40, Hirudo 20-40, Radix Et Rhizoma Rhei 20-40, Aloe 10-20.
Pharmaceutical formulation weight of the present invention (part) preferable range is:
Bufo siccus 30-40, Gekko Swinhonis 32-35, Fructus Camptothecae Acuminatae 42-48, Rhizoma Paridis 24-35, Radix Astragali 70-90, Radix Ginseng 24-35, eupolyphaga 32-38, Hirudo 22-35, Radix Et Rhizoma Rhei 25-35, Aloe 12-18.
Drug weight of the present invention (part) the best is:
Bufo siccus 40, Gekko Swinhonis 35, Fructus Camptothecae Acuminatae 50, Rhizoma Paridis 35, the Radix Astragali 90, Radix Ginseng 38, eupolyphaga 38, Hirudo 35, Radix Et Rhizoma Rhei 40, Aloe 18.
Above-mentioned each component is made medicine production method of the present invention is:
Select for use dry Bufo siccus to remove internal organs, bake to the sallow fine powder that is ground into slow fire; Gekko Swinhonis is wanted the magnetic tape trailer crust, and is not broken, dries in the shade with grinding; Eupolyphaga, Hirudo are dried in the shade with the product of giving birth to.Fructus Camptothecae Acuminatae debranching leaf, impurity, Rhizoma Paridis is got root and is cleaned, dries in the shade, and the Radix Astragali is got root, and Radix Ginseng goes reed, and Radix Et Rhizoma Rhei, Aloe are mixed thoroughly in proportion with the product of giving birth to, and use the fine crash cells wall breaking technology of ultralow temperature then, and after the fine powder that powder is crossed stirred, packing into 0.4 restrained capsule.
Compatibility of drugs principle of the present invention:
Be monarch drug with Bufo siccus, Gekko Swinhonis in the medicine of the present invention, the detumescence of drawing out pus by applying a plaster to the affected part, detoxicating and resolving stagnation of pathogens is treated malignant boil, the carbuncle of yin nature of dispelling, removing water retention by purgation toxin expelling, apoptosis pyknosis oncocyte.The infringement to human body such as cancer material (bent bambermycin, nitrite, nitrosamine, viral micro-organisms) is controlled in blocking-up again, removes its toxic reaction.
Fructus Camptothecae Acuminatae, the Radix Astragali, Radix Ginseng are ministerial drug, and auxiliary Bufo siccus, Gekko Swinhonis are directly killed cancerous cell, and its vigor becomes extinct.The Radix Astragali, Radix Ginseng strongly invigorating QI and blood contain flavone and the multiple chemical compound of Saponin class, again and selenium supplement, remove tired, strong immunity, and disturb and engulf cancerous cell, be again assisted and strengthened dose in the anticarcinogen, anticancer drug effect is improved more than the several times.
Hirudo, eupolyphaga, Radix Et Rhizoma Rhei are adjuvant drug, blood circulation promoting and blood stasis dispelling, eliminate speckle, catharsis and toxin expelling is dispeled oxygen-derived free radicals, improves and the stiff tensity of loose esophagus, recover its swallowing act, make the due to intestine erosion and ulcer of esophagus, cardia cancer the change of erythema sample occur, epithelium is repaired gradually, finally forms the normal structure form of esophagus.
Rhizoma Paridis is a messenger drug, removing pathogenic heat from blood and toxic substance from the body, and the tool cancer vigor that goes out can guide and lead the cancer efficacy component that goes out to carry out in the cancerous cell nuclear again, direct kill cancer cell, thus, Rhizoma Paridis has the powerful effectiveness that penetrates cancer cell membrane, so make the usefulness of tying-in again.
Pharmacological function of the present invention:
Heat clearing away, detoxifcation, counteracting toxic substances, draw out pus by applying a plaster to the affected part, toxin expelling, detumescence, eliminating stagnation, removing heat from blood, blood stasis dispelling, pain relieving, antiinflammatory, set upright, increase and exempt from.
Consumption and method of administration:
Each clothes 0.8 gram of adult, three times on the one.One month is a course of treatment.After the course of treatment, had a rest five days, then take the next course of treatment.Two feeds course of treatment are semi-fluid, and can recover normal swallowing act 4 courses of treatment.
Take during this medicine, avoid pungent food, drink and smoking, eat the nutraceutical that contains high protein more, as fresh fish, lean meat, egg milk and vegetable.
Medicine of the present invention also can be treated gastric cancer, colon cancer, rectum cancer; The anti-relapse and metastasis of postoperative gastric cancer also there is certain therapeutical effect.
The specific embodiment
Embodiment: get raw material (part) by following proportioning
Bufo siccus 40 grams, Gekko Swinhonis 35 grams, Fructus Camptothecae Acuminatae 50 grams, Rhizoma Paridis 35 grams, the Radix Astragali 90 grams, Radix Ginseng 38 grams, eupolyphaga 38 grams, Hirudo 35 grams, Radix Et Rhizoma Rhei 40 grams, Aloe 18 grams.
Production method: get dry Bufo siccus and remove internal organs, be cut into small pieces, to sallow, leave sustainability, be ground into fine powder with the slow fire roasting.Gekko Swinhonis will have tail, can not break, otherwise lower drug effect, dries with slow fire, is ground into fine powder.Fructus Camptothecae Acuminatae is picked up decontamination and branch and leaf, dries in the shade; Rhizoma Paridis, the Radix Astragali, Radix Ginseng (going reed), eupolyphaga, Hirudo, Radix Et Rhizoma Rhei, Aloe all with the product of giving birth to, are dried in the shade with grinding.
According to the deployed in proportion drug dose of technical formula, use the fine crash cells wall breaking technology of ultralow temperature then, product fineness reaches 40um (300 orders are following), the cell wall breaking rate reaches 〉=(require meticulous more than 98%, biological activity availability height), in crushing process, must note the variations in temperature of institute's powder powder, can't the messenger drug surface temperature too high and reduce the biological activity of medicine, in order to avoid lower drug effect.Why need not decoct and extract or spissated manufacture method, purpose is exactly destroyed or lose for fear of the effective active of medicine.Treat that medicated powder is broken complete, after stirring, the 0.4 gram capsule of packing into.
The clinical observation on the therapeutic effect report
1, clinical data
Selection of clinical 14 routine typical patients all are the out-patient, male's 8 examples wherein, women's 6 examples, the age between 55～72 years old, esophageal squamous cell carcinoma 9 examples wherein, cardiac adenocarcinoma 5 examples; Companion's hepatic metastases 1 example, lymph metastasis 12 examples, lung shifts 1 example; Medical history is in above person's 4 examples of 4mo, above person's 10 examples of 6mo, and wherein 14 examples are with the thoracic dorsal dull pain, and 2 examples are spitted blood.
2, diagnostic criteria
Clinical manifestation with esophagus stifled choke, preventricular stenosis, continue outbreak more than 2 months, breastbone, back causalgia appear, dull pain, distending pain, vomiting sputum, vomiting belch, anemia or haematemesis, positive signs such as constipation with dry stool, the cancerous protuberance compressing is invaded adjacent tissue and hoarseness, Horner syndrome are occurred, and drinking-water is choked and coughed and cachexia lymph metastasis, as seen supraclavicular lymph nodes enlargement, blood testing detects: leukocyte, hemoglobin descend.Gastroscope, CT, pathological biopsy and canel barium meal contrast examination inspection: to be that cancerous cell is positive soak into esophageal lumen focus mucosa, and the esophagus lesions position is erosion, ulcer, spot, Histological change such as stiff, narrow.
3, therapeutic scheme
The esophageal carcinoma and carcinoma of gastric cardia patient oral " toad Long Kang " capsule, each 2 of usual amounts of adult, every day 3 times, along with the prolongation of medicine time can be incremented to 3, curative effect also strengthens thereupon.If esophagostenosis under the capsule difficulty, can transform the capsule that removes photoresist into, get powder and take.
Period in a medicine taboo: drink, stimulus object such as pungent, greasy, coffee.
4, efficacy assessment standard:
According to national esophagus cancer diagnosis curative effect judging standard.This capsule curative effect judging standard divides level Four, i.e. recovery from illness is alleviated, and produce effects is effectively, invalid.
Clinical symptom disappearance or significantly improvement continue to alleviate more than the 3-5, and the gastroscopy foci disappearance is for curing; The symptom basic controlling, gastroscope shows: rotten to the corn narrowly alleviate more than halfly, body constitution is obviously recovered, and existence 1-2 person is a produce effects; Symptom is partly alleviated, and lesions position slightly improves, for effectively; Symptom does not take a turn for the better, and focus does not have improvement, and patient's body constitution descends gradually, for invalid.
5, therapeutic effect
5.1 clinical efficacy
| The example number | Recovery from illness is alleviated | Produce effects | Effectively | Invalid | Cure rate | Total effective rate |
| 14 | 8 | 1 | 2 | 3 | 57.2％ | 86.6％ |
The above results shows that this Chinese patent medicine " toad Long Kang " capsule cure rate reaches 57.2%, and wherein invalid 3 examples have 2 routine therapy discontinued, and 1 example shifts the lung liver.
5.2 the situation of change of clinical symptoms
Change from the front and back of treatment symptom, notable difference is arranged, illustrate that toad dragon recovering capsule treatment esophageal carcinoma effect is satisfied.
6, efficacy analysis
(1) the cancer poison is seated esophagus, cardia position, is due to intestine erosion and ulcer, spot is narrow, again and cloudy, the hypoperistalsis of bright Tianjin consumption.Poison dirt is last, swallows the stalk anorexia of choking, and robs bright infra, and constipation with dry stool excrement such as ball are controlled and worked as catharsis and toxin expelling, and the blood stasis dispelling heavily fortified point that disappears makes the part of the body cavity above the diaphragm housing the heart and lungs stop up the cancer poison of knot, cleanses and goes from the intestinal internal organs, and Rheum officinale, Aloe and so on are also.
(2) removing water retention by purgation toxin expelling, purpose are the water content that reduces cancerous cell, because of cancerous cell water content person up to more than 80%, normal cell does not have this phenomenon.The purpose of removing water retention by purgation is the vigor that appears vividly that slackens cancerous cell, suppresses its procreation and multiplies, and removing water retention by purgation promptly is to kill cancer thus, such as Bufo siccus, Gekko Swinhonis, Fructus Camptothecae Acuminatae, Rhizoma Paridis etc., can stand and suppress cancer, and tool is received good effect.
(3) another behave of beat cancer is the enhancing human body immunity function, and purpose is the value that increases of promoting leucocytes, TB cell and thymosin, be used for disturbing and engulfing cancerous cell, Fuzheng Jiedu not only, again and kill the cancer detoxification, to having a delicate constitution, and the rampant person of cancer poison has good therapeutic effect.
Conclusion
Clearly show that from above-mentioned situation medicine of the present invention improves condition of illness to esophageal carcinoma, carcinoma of gastric cardia, recover the esophageal peristalsis function, prolonging patient's life has good effect.Idea and method has one's own knack, and this is the creative contribution to Chinese medicine and pharmacy, applies and must bring benefit to the mankind.
Claims (4)
1. medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia is characterized in that it is made up of following components in part by weight: Bufo siccus 25-45, Gekko Swinhonis 30-40, Fructus Camptothecae Acuminatae 40-60, Rhizoma Paridis 20-40, Radix Astragali 60-100, Radix Ginseng 20-40, eupolyphaga 30-40, Hirudo 20-40, Radix Et Rhizoma Rhei 20-40, Aloe 10-20.
2. a kind of medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia according to claim 1, it is characterized in that formulation weight part scope is: Bufo siccus 30-40, Gekko Swinhonis 32-35, Fructus Camptothecae Acuminatae 42-48, Rhizoma Paridis 24-35, Radix Astragali 70-90, Radix Ginseng 24-35, eupolyphaga 32-38, Hirudo 22-35, Radix Et Rhizoma Rhei 25-35, Aloe 12-18.
3. a kind of medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia according to claim 1 is characterized in that weight portion is: Bufo siccus 40, Gekko Swinhonis 35, Fructus Camptothecae Acuminatae 50, Rhizoma Paridis 35, the Radix Astragali 90, Radix Ginseng 38, eupolyphaga 38, Hirudo 35, Radix Et Rhizoma Rhei 40, Aloe 18.
4. a kind of medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia according to claim 1 is characterized in that its preparation method is: take by weighing each raw material by following weight portion: Bufo siccus 25-45, Gekko Swinhonis 30-40, Fructus Camptothecae Acuminatae 40-60, Rhizoma Paridis 20-40, Radix Astragali 60-100, Radix Ginseng 20-40, eupolyphaga 30-40, Hirudo 20-40, Radix Et Rhizoma Rhei 20-40, Aloe 10-20, select for use dry Bufo siccus to remove internal organs, bake to the sallow fine powder that is ground into slow fire; Gekko Swinhonis is wanted the magnetic tape trailer crust, and is not broken, dries in the shade with grinding; Eupolyphaga, Hirudo are dried in the shade with the product of giving birth to; Fructus Camptothecae Acuminatae debranching leaf, impurity, Rhizoma Paridis is got root and is cleaned, dries in the shade, and the Radix Astragali is got root, and Radix Ginseng goes reed, and Radix Et Rhizoma Rhei, Aloe are mixed thoroughly in proportion with the product of giving birth to, and use the fine crash cells wall breaking technology of ultralow temperature then, and after the fine powder that powder is crossed stirred, packing into 0.4 restrained capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100153686A CN100391505C (en) | 2005-10-11 | 2005-10-11 | Medicine for treating esophagus cancer and cardia cancer and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100153686A CN100391505C (en) | 2005-10-11 | 2005-10-11 | Medicine for treating esophagus cancer and cardia cancer and its prepn. method |
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| Publication Number | Publication Date |
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| CN1947769A CN1947769A (en) | 2007-04-18 |
| CN100391505C true CN100391505C (en) | 2008-06-04 |
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| CNB2005100153686A Expired - Fee Related CN100391505C (en) | 2005-10-11 | 2005-10-11 | Medicine for treating esophagus cancer and cardia cancer and its prepn. method |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101757602B (en) * | 2010-04-07 | 2011-04-06 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composition for treating cardiac carcinoma and preparation method thereof |
| CN105998780A (en) * | 2016-06-01 | 2016-10-12 | 张志仁 | Medicine for treating esophagus cancer and cardiac cancer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327807A (en) * | 2000-06-12 | 2001-12-26 | 吴建华 | Chinese medicine for treating neoplasm |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327807A (en) * | 2000-06-12 | 2001-12-26 | 吴建华 | Chinese medicine for treating neoplasm |
Non-Patent Citations (4)
| Title |
|---|
| 虫类中药治癌痛概况. 李继福等.光明中医杂志，第3期. 1996 |
| 虫类中药治癌痛概况. 李继福等.光明中医杂志，第3期. 1996 * |
| 食管癌的中医药治疗进展. 陈成东等.福建中医药，第35卷第5期. 2004 |
| 食管癌的中医药治疗进展. 陈成东等.福建中医药，第35卷第5期. 2004 * |
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