CN101757602B - Traditional Chinese medicine composition for treating cardiac carcinoma and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating cardiac carcinoma and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a novel traditional Chinese medicine composition for treating cardiac carcinoma and a preparation method thereof. The traditional Chinese medicine composition mainly comprises the raw materials of lignum dalbergiae odoriferae, szechuan lovage rhizome, alosewood, costus root, pericarpium citri reticulatae, poria, frankincense, myrrh, Chinese lobelia herb, whiteflower patrinia herb, ground beetle, malayan pangolin, leech, rhubarb, Chinese goldthread, honeysuckle flower, philippine violet herb, grassleaf sweelflag rhizome, radix sophorae tonkinensis, medicated leaven, immature bitter orange, India madder root, dried ginger, peppermint, sophora flavescens ait, and the like. The traditional Chinese medicine composition can be prepared into any common oral preparation bythe conventional preparation method of traditional Chinese medicines. The invention can obviously improve symptoms, such as upper gastrointestinal hemorrhage, food retention or non-smooth feeling, stomach pain, marasmus, anemia, edema, hepatic failure, coma, gastroduodenal obstruction, and the like and has definite and significant clinical curative effect and quick effectiveness. Because the traditional Chinese medicine composition is combined by medicaments which are specified as both food and medicine in a national pharmacopoeia basically, the invention has the advantages of low cost, almost no toxic or side effect, and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of carcinoma of gastric cardia.Relating in particular to a kind of is the Chinese medicine composition and preparation method thereof of the treatment carcinoma of gastric cardia of crude drug with the Chinese herbal medicine.
Background technology
Carcinoma of gastric cardia is to occur in stomachus cardiacus, i.e. adenocarcinoma in about 2cm scope under esophagus and the stomach boundary line.With upper gastrointestinal hemorrhage, eat stagnate or the pause and transition in rhythm or melody sense, have a stomachache, become thin, anemia, edema, liver failure, stupor, digestive tract are blocked etc. is main clinical manifestation.In China, the mortality rate of carcinoma of gastric cardia and sickness rate rank among the best in all kinds of malignant tumor, have data to show, the mortality rate of carcinoma of gastric cardia accounts for about 12% of general mortality rate, and local hotspot can reach 20%.Serious threat human health and life, the clinical onset rate has the trend of continuous rising in recent years.
Because its histology is adenocarcinoma or mucinous adenocarcinoma, the radiotherapy nearly unavailable, chemical therapeutic effect is also very little, up to now, operative treatment is the prefered method of the carcinoma of gastric cardia of generally acknowledging, but the surgery cost height, very big to injury of human, postoperative recurrence rate height, survival rate is low, in order to overcome above-mentioned defective, the present invention is based on the differential diagnosis of diseases and the dialectical principle that combines of Chinese traditional treatment carcinoma of gastric cardia, treating both the principal and secondary aspects of a disease, deficiency and excess is also controlled, inside and outside logical accent, emergency is taken in concurrently, filter out blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, the body resistance strengthening and constitution consolidating, anticancer analgetic, the natural plant of regulating liver and qi according to the theory of Chinese medical science prescription, is prepared from according to certain weight proportion.A kind of Chinese medicine composition of evident in efficacy, with low cost, treatment carcinoma of gastric cardia that toxic and side effects is minimum is provided.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage forms, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be: pill, capsule, tablet, powder, granule or oral liquid etc.
Summary of the invention
Technical problem to be solved by this invention is assorted to overcome above-described shortcoming, and a kind of Chinese medicine composition of treatment carcinoma of gastric cardia of evident in efficacy, with low cost, almost non-toxic side effect is provided.
The technical problem of the desired solution of the present invention realizes by following technological approaches.
A kind of Chinese medicine composition for the treatment of carcinoma of gastric cardia of the present invention, the component of main following weight portion is formed:
1～120 part of Lignum Dalbergiae Odoriferae, 1～100 part of Lignum Aquilariae Resinatum, 1～100 part of Rhizoma Chuanxiong, 1～120 part of the Radix Aucklandiae, 1～150 part of Pericarpium Citri Reticulatae, 1～300 part in Poria, 1～100 part of Olibanum (processed), 1～100 part of Myrrha (processed), 1～120 part of Indigo Naturalis, 1～100 part of Herba Andrographis, 1～100 part of Herba Lobeliae Chinensis, 1～120 part of Herba Patriniae, 1～50 part of Eupolyphaga Seu Steleophaga, 1～100 part of Squama Manis, 1～50 part of Hirudo, 1～100 part of Radix Et Rhizoma Rhei, 1～100 part of Rhizoma Coptidis, 1～100 part of Radix Scutellariae, 1～120 part of Herba Taraxaci, 1～120 part of Flos Lonicerae, 1～100 part of Herba Violae, 1～100 part of Fructus Bruceae, 1～100 part of Rhizoma Belamcandae, 1～150 part of Radix Sophorae Tonkinensis, 1～120 part in Talcum, 1～120 part of 1～120 part of Herba Polygoni Avicularis of Rhizoma Acori Graminei, 1～100 part of Herba Dianthi, 1～150 part of Massa Medicata Fermentata, 1～100 part on Pericarpium Citri Reticulatae Viride, 1～120 part of Fructus Aurantii Immaturus, 1～120 part in Radix Rubiae, 1～50 part in catechu, 1～50 part of Rhizoma Zingiberis, 1～50 part of Herba Menthae, 1～150 part of Radix Puerariae.
Be preferably:
30 parts of Lignum Dalbergiae Odoriferaes, 15 parts of Lignum Aquilariae Resinatum, 20 parts of Rhizoma Chuanxiongs, 30 parts of the Radix Aucklandiae, 50 parts of Pericarpium Citri Reticulataes, 50 parts in Poria, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 20 parts of Indigo Naturaliss, 20 parts of Herba Andrographis, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Patriniae, 15 parts of Eupolyphaga Seu Steleophagas, 20 parts of Squama Maniss, 15 parts of Hirudos, 30 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Coptidis, 20 parts of Radix Scutellariaes, 20 parts of Herba Taraxaci, 30 parts of Flos Loniceraes, 20 parts of Herba Violaes, 20 parts of Fructus Bruceaes, 20 parts of Rhizoma Belamcandae, 50 parts of Radix Sophorae Tonkinensiss, 20 parts in Talcum, 20 parts of 30 parts of Herba Polygoni Avicularis of Rhizoma Acori Graminei, 20 parts of Herba Dianthis, 30 parts of Massa Medicata Fermentata, 20 parts on Pericarpium Citri Reticulatae Viride, 30 parts of Fructus Aurantii Immaturuss, 20 parts in Radix Rubiae, 15 parts in catechu, 15 parts of Rhizoma Zingiberiss, 10 parts of Herba Menthaes, 50 parts of Radix Puerariaes.
The weight portion consumption of each component of Chinese medicine composition of the present invention can also be:
1～100 part of Radix Ampelopsis, 1～60 part of Fructus Gardeniae, 1～150 part of Radix Trichosanthis, 1～120 part of Radix Sophorae Flavescentis, 1～120 part of Cortex Fraxini, 1～100 part of Folium Sennae, 1～100 part of Aloe, 1～100 part of Succus Bambusae, 1～100 part of Cortex Magnoliae Officinalis, 1～100 part of Fructus Amomi, 1～150 part of the Radix Paeoniae Alba, 1～50 part in Semen Persicae, 1～50 part on Flos Carthami, 1～50 part of rhizoma sparganic, 1～50 part of Rhizoma Curcumae, 1～150 part of Semen Coicis, 1～100 part of Pollen Typhae, 1～120 part of Radix Notoginseng, 1～50 part of Pseudobulbus Bletillae (Rhizoma Bletillae), 1～100 part of Nodus Nelumbinis Rhizomatis, 1～100 part of Radix Salviae Miltiorrhizae, 1～100 part of Herba Lycopi, 1～100 part of Semen Vaccariae, 1～100 part of Flos Chrysanthemi.
Be preferably:
20 parts of Radix Ampelopsis, 15 parts of Fructus Gardeniaes, 30 parts of Radix Trichosanthis, 20 parts of Radix Sophorae Flavescentiss, 20 parts of Cortex Fraxinis, 15 parts of Folium Sennae, 20 parts of Aloes, 20 parts of Succus Bambusaes, 20 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Amomis, 30 parts of the Radix Paeoniae Albas, 15 parts in Semen Persicae, 15 parts on Flos Carthami, 15 parts of rhizoma sparganic, 15 parts of Rhizoma Curcumae, 50 parts of Semen Coiciss,, 20 parts of Pollen Typhaes, 30 parts of Radix Notoginseng, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Nodus Nelumbinis Rhizomatis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba Lycopi, 20 parts of Semen Vaccariae, 10 parts of Flos Chrysanthemis.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be pill, capsule, tablet, powder, granule or oral liquid etc.
Chinese medicine composition of the present invention is opened one's minds based on traditional Chinese medical science the five internal organs differentiation of syndromes of YIN and YANG guiding principle, in conjunction with safe one and Pu innovation theory system " ten thousand diseases ascent theory ", " the five internal organs differentiation of syndromes of YIN and YANG guiding principle ", " three-dimensional conservation regulation and control rule " and clinical treatment " pairing principle " are as instructing, take place in conjunction with disease, development and the rule that changes, classify according to the original new drug system, formation is monarch with " the five internal organs basic function is adjusted; equilibrium between yin and yang coordination side ", " the main pathogenesis of the five internal organs adjustment side " is minister, " therapy of serious disease side " is assistant, " clinical fundamental symptoms symptomatic treatment side " Chinese medicine patent medicine " original new drug system " for making.
The used herbal raw material medicine of the present invention all can be buied from the Chinese medicine shop, and its specification meets national medical standard.
Usage and dosage: dosage of the present invention depends on concrete dosage form, factors such as patient age, body weight, health status.As guidance: for oral administration: 1) capsule: obey 2～5 every day three times at every turn, every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.5) powder: every day three times, each 2～4 grams, warm water takes.
The treatment that the present invention is directed to the carcinoma of gastric cardia patient is very effective, various crude drug are coordinated mutually can play together and are at utmost brought into play drug effect, can effectively improve the self-coordination ability of patient's body, significantly improve function and clinical subjective symptoms, have advantage such as have no side effect, expense is lower in addition.
The specific embodiment
Further describe the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never are limited to the present invention.
The preparation of [embodiment 1] capsule
Take by weighing each raw material by following weight portion: 30 parts of Lignum Dalbergiae Odoriferaes, 15 parts of Lignum Aquilariae Resinatum, 20 parts of Rhizoma Chuanxiongs, 30 parts of the Radix Aucklandiae, 50 parts of Pericarpium Citri Reticulataes, 50 parts in Poria, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 20 parts of Indigo Naturaliss, 20 parts of Herba Andrographis, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Patriniae, 15 parts of Eupolyphaga Seu Steleophagas, 20 parts of Squama Maniss, 15 parts of Hirudos, 30 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Coptidis, 30 parts of Flos Loniceraes, 20 parts of Herba Violaes, 20 parts of Rhizoma Belamcandae, 50 parts of Radix Sophorae Tonkinensiss, 20 parts in Talcum, 30 parts of Rhizoma Acori Graminei, 30 parts of Fructus Aurantii Immaturuss, 20 parts in Radix Rubiae, 15 parts in catechu, 15 parts of Rhizoma Zingiberiss, 10 parts of Herba Menthaes, 50 parts of Radix Puerariaes, 15 parts of Folium Sennae, 20 parts of Aloes, 30 parts of the Radix Paeoniae Albas, 15 parts in Semen Persicae, 15 parts on Flos Carthami, 15 parts of rhizoma sparganic, 15 parts of Rhizoma Curcumae, 50 parts of Semen Coiciss, 20 parts of Pollen Typhaes, 30 parts of Radix Notoginseng, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Nodus Nelumbinis Rhizomatis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba Lycopi, 20 parts of Semen Vaccariae, 10 parts of Flos Chrysanthemis.
Grind into after each component mixing with above-mentioned weight and incapsulate promptly after fine powder is crossed 1500 mesh sieves.
The preparation of [embodiment 2] granule
Take by weighing each raw material by following weight portion: 30 parts of Lignum Dalbergiae Odoriferaes, 15 parts of Lignum Aquilariae Resinatum, 20 parts of Rhizoma Chuanxiongs, 30 parts of the Radix Aucklandiae, 50 parts of Pericarpium Citri Reticulataes, 50 parts in Poria, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 20 parts of Indigo Naturaliss, 20 parts of Herba Andrographis, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Patriniae, 15 parts of Eupolyphaga Seu Steleophagas, 20 parts of Squama Maniss, 15 parts of Hirudos, 30 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Coptidis, 30 parts of Flos Loniceraes, 20 parts of Herba Violaes, 20 parts of Rhizoma Belamcandae, 50 parts of Radix Sophorae Tonkinensiss, 20 parts in Talcum, 30 parts of Rhizoma Acori Graminei, 30 parts of Fructus Aurantii Immaturuss, 20 parts in Radix Rubiae, 15 parts in catechu, 15 parts of Rhizoma Zingiberiss, 10 parts of Herba Menthaes, 50 parts of Radix Puerariaes, 15 parts of Folium Sennae, 20 parts of Aloes, 30 parts of the Radix Paeoniae Albas, 15 parts in Semen Persicae, 15 parts on Flos Carthami, 15 parts of rhizoma sparganic, 15 parts of Rhizoma Curcumae, 50 parts of Semen Coiciss, 20 parts of Pollen Typhaes, 30 parts of Radix Notoginseng, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Nodus Nelumbinis Rhizomatis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba Lycopi, 20 parts of Semen Vaccariae, 10 parts of Flos Chrysanthemis.
Each raw material of above-mentioned weight fraction is mixed, after grinding into fine powder and crossing 1500 mesh sieves, add ethanol and make adhesive, add starch and do filler, be pressed into granule.
The preparation of [embodiment 3] tablet
Take by weighing each raw material by following weight portion: 30 parts of Lignum Dalbergiae Odoriferaes, 15 parts of Lignum Aquilariae Resinatum, 20 parts of Rhizoma Chuanxiongs, 30 parts of the Radix Aucklandiae, 50 parts of Pericarpium Citri Reticulataes, 50 parts in Poria, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 20 parts of Indigo Naturaliss, 20 parts of Herba Andrographis, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Patriniae, 15 parts of Eupolyphaga Seu Steleophagas, 20 parts of Squama Maniss, 15 parts of Hirudos, 30 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Coptidis, 30 parts of Flos Loniceraes, 20 parts of Herba Violaes, 20 parts of Rhizoma Belamcandae, 50 parts of Radix Sophorae Tonkinensiss, 20 parts in Talcum, 30 parts of Rhizoma Acori Graminei, 30 parts of Fructus Aurantii Immaturuss, 20 parts in Radix Rubiae, 15 parts in catechu, 15 parts of Rhizoma Zingiberiss, 10 parts of Herba Menthaes, 50 parts of Radix Puerariaes, 15 parts of Folium Sennae, 20 parts of Aloes, 30 parts of the Radix Paeoniae Albas, 15 parts in Semen Persicae, 15 parts on Flos Carthami, 15 parts of rhizoma sparganic, 15 parts of Rhizoma Curcumae, 50 parts of Semen Coiciss, 20 parts of Pollen Typhaes, 30 parts of Radix Notoginseng, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Nodus Nelumbinis Rhizomatis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba Lycopi, 20 parts of Semen Vaccariae, 10 parts of Flos Chrysanthemis.
Each raw material of above-mentioned weight portion is mixed, after grinding into fine powder and crossing 800～1200 order dusting covers, make tablet promptly.
The preparation of [embodiment 4] pill
Take by weighing each raw material by following weight portion: 30 parts of Lignum Dalbergiae Odoriferaes, 15 parts of Lignum Aquilariae Resinatum, 20 parts of Rhizoma Chuanxiongs, 30 parts of the Radix Aucklandiae, 50 parts of Pericarpium Citri Reticulataes, 50 parts in Poria, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 20 parts of Indigo Naturaliss, 20 parts of Herba Andrographis, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Patriniae, 15 parts of Eupolyphaga Seu Steleophagas, 20 parts of Squama Maniss, 15 parts of Hirudos, 30 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Coptidis, 30 parts of Flos Loniceraes, 20 parts of Herba Violaes, 20 parts of Rhizoma Belamcandae, 50 parts of Radix Sophorae Tonkinensiss, 20 parts in Talcum, 30 parts of Rhizoma Acori Graminei, 30 parts of Fructus Aurantii Immaturuss, 20 parts in Radix Rubiae, 15 parts in catechu, 15 parts of Rhizoma Zingiberiss, 10 parts of Herba Menthaes, 50 parts of Radix Puerariaes, 15 parts of Folium Sennae, 20 parts of Aloes, 30 parts of the Radix Paeoniae Albas, 15 parts in Semen Persicae, 15 parts on Flos Carthami, 15 parts of rhizoma sparganic, 15 parts of Rhizoma Curcumae, 50 parts of Semen Coiciss, 20 parts of Pollen Typhaes, 30 parts of Radix Notoginseng, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Nodus Nelumbinis Rhizomatis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba Lycopi, 20 parts of Semen Vaccariae, 10 parts of Flos Chrysanthemis.
Each raw material of above-mentioned weight is mixed, grind into cross 600～1000 mesh sieves behind the fine powder after, make pill promptly.
The preparation of [embodiment 5] oral liquid
Take by weighing each raw material by following weight portion: 30 parts of Lignum Dalbergiae Odoriferaes, 15 parts of Lignum Aquilariae Resinatum, 20 parts of Rhizoma Chuanxiongs, 30 parts of the Radix Aucklandiae, 50 parts of Pericarpium Citri Reticulataes, 50 parts in Poria, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 20 parts of Indigo Naturaliss, 20 parts of Herba Andrographis, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Patriniae, 15 parts of Eupolyphaga Seu Steleophagas, 20 parts of Squama Maniss, 15 parts of Hirudos, 30 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Coptidis, 30 parts of Flos Loniceraes, 20 parts of Herba Violaes, 20 parts of Rhizoma Belamcandae, 50 parts of Radix Sophorae Tonkinensiss, 20 parts in Talcum, 30 parts of Rhizoma Acori Graminei, 30 parts of Fructus Aurantii Immaturuss, 20 parts in Radix Rubiae, 15 parts in catechu, 15 parts of Rhizoma Zingiberiss, 10 parts of Herba Menthaes, 50 parts of Radix Puerariaes, 15 parts of Folium Sennae, 20 parts of Aloes, 30 parts of the Radix Paeoniae Albas, 15 parts in Semen Persicae, 15 parts on Flos Carthami, 15 parts of rhizoma sparganic, 15 parts of Rhizoma Curcumae, 50 parts of Semen Coiciss, 20 parts of Pollen Typhaes, 30 parts of Radix Notoginseng, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Nodus Nelumbinis Rhizomatis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba Lycopi, 20 parts of Semen Vaccariae, 10 parts of Flos Chrysanthemis.
Each raw material of above-mentioned weight is mixed, after three decoctions, three filtrates are mixed, filter, be concentrated into rule
Fixed concentration, put cold, the stock solution embedding, irradiation sterilization, after the check, packed products is made oral liquid promptly.
[experimental example] traditional Chinese medicine composition for treating carcinoma of gastric cardia of the present invention patient's clinical observation on the therapeutic effect experiment
One, the physical data of experimental subject: adopt Chinese medicine composition of the present invention to treat 105 routine patients altogether, wherein male 75 examples, women 30 examples; The oldest person 76 years old, the age reckling has only 35 years old.
Two, Therapeutic Method:
Usage and dosage: adopt the prepared medicament of the embodiment of the invention, its usage and consumption are as follows: 1) capsule: obey 2～5 every day three times at every turn, and every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.5) powder: every day three times, each 2～4 grams, warm water takes.
The course of treatment: one month is a course of treatment, treats for 12 courses of treatment altogether.
Three, therapeutic evaluation standard
Cure: sign and symptom are improved fully, swallow normal, happy, in high spirits.
Produce effects: sign and symptom are significantly improved, and swallow normal substantially, happy, spiritual fine.
Effectively: sign and symptom change, and swallow improvement, and random thoughts have discomfort slightly, but can accept.
Invalid: sign does not have change, symptom such as preceding.
Four, model case:
1, Zhao, man, 46 years old, cadre.
Patient previously body is strong, because of " carrying out property feed difficulty 6 months " is admitted to hospital.The upper digestive tract radiography shows: preventricular stenosis, and filling defect, the mucosa wall destroys and interrupts.Gastroscope shows: the hyperemia of pars cardiaca mucosa, and edema has the big aphtha kitchen range of an about 0.5cm * 1cm, pathological replacement: adenocarcinoma, examine and be carcinoma of gastric cardia.Examine and see: patient's epigastrium pain, vomiting clear water sputum, light night in daytime is heavy, influence feed and sleep, weak breath is weak, and health is become thin.Pale tongue, lingual surface water is wet, and tongue is white, soft and thready pulse.
Took Chinese medicine composition of the present invention 15, the epigastrium pain relief, vomiting gradually ends, and it is good slightly to sleep.Continue and obeyed Chinese medicine composition of the present invention 1 month, gastroscope shows: focus is more preceding significantly dwindles, and symptom is further alleviated, and diet increases, and sleep takes a turn for the better, and muscle power is recovered to some extent, and patient's confidence heightens, and spirit takes a turn for the better.Continue and obeyed Chinese medicine composition of the present invention 3 months, symptom fades away, weight increase.Obeyed Chinese medicine composition of the present invention again nearly 6 months, and checked all normally, all diseases are all removed, and resume work, and follow up a case by regular visits to so far, and are all right.
2, land, woman, 58 years old, retired worker.
Because of carrying out property dysphagia, companion's pain January, esophagoscope is seen apart from front tooth 41cm place esophagus rear wall has lump to give prominence to local loss of peristalsis.Be diagnosed as the esophagus carcinoma of gastric cardia, the patient is reluctant operation and comes this place to take traditional Chinese medicine, and during first visit, main suit's dysphagia can only influent stream matter, semiliquid diet, burn feeling and dull pain behind the breastbone, greasy and thin fur, stringy and rolling pulse.
Took Chinese medicine composition of the present invention 7, pain relief, a small amount of rotten soft cooked rice of taking food.Continue and obeyed Chinese medicine composition of the present invention 1 month, pain is greatly alleviated, and symptom alleviates gradually, and the state of an illness gets better every day, and is happy.Continue and obeyed Chinese medicine composition of the present invention 2 months, it is normal that feed recovers, and can eat steamed bread, pancake etc., and the spirit continuation takes a turn for the better, and clinical symptoms fades away.The clothes Chinese medicine composition of the present invention that continues is surplus June, and symptom all disappears, and the patient lives normally, and in the past few years, situation is stable.
3, Liu, man, 60 years old, retired cadre.
The patient before 2 years October become thin, anemia because of carrying out property dysphagia, hospital does gastroscopy, pathological replacement: cardia adenocarcinoma.Implement the cardia tumorectomy November, residual stomach, esophagus coincide.Postoperative carried out chemotherapy in 1 month, and the chemotherapeutic period reaction is heavier, felt sick, vomitted, and can not advance any food, and health is weak more, have to abandon chemotherapy.Before January, occur serious anemia once more, tell a large amount of mucus every day, weight loss 15Kg, walking along the street needs other people to assist in, through gastroscopy, report stoma ulcer, carcinoma of gastric cardia recurrence.
Took Chinese medicine composition of the present invention 15, but independent ambulation, doing well,improving.Continue and obeyed Chinese medicine composition of the present invention 1 month, sensation has been walked energetically, and general sensation is also light, tells mucus and obviously reduces, and it is ruddy that complexion also becomes.Continue and obeyed Chinese medicine composition of the present invention 2 months, weight increase can come and go 10 kilometers by bike, and symptom is greatly taken on a new look.It is surplus July to obey Chinese medicine composition of the present invention again, and symptom disappears substantially, and is in high spirits, follows up a case by regular visits to so far, checks repeatedly through B ultrasonic, every chemical examination during the patient, does not see recurrence and shifts sign.
4, congratulate so-and-so, woman, 67 years old, retired worker.
The patient begins to occur the glutted discomfort of epigastrium in April, 2006, the feed postemphasis, and food entrapment sense under companion's xiphoid-process is failed to respond to any medical treatment by " gastropathy ".And sx begins to occur dysphagia, anorexia, and burn feeling behind the breastbone, sharp ache are become thin, and appetite is poor, poor sleeping quality.Gastroscope shows: see the huge protrude type of the one 4.0 * 3.5CM thing that swells at the bottom of the stomach: tumor be the edge more clearly to the lump of intracavity protuberance, be cauliflower form, there is fester on the surface, draws in the net cytolgical examination: the cardia well-differentiated adenocarcinoma.
Took Chinese medicine composition of the present invention 15, pain is significantly alleviated, and surplus disease decrescence.Continue and obeyed Chinese medicine composition of the present invention 1 month, swallow improvement, pain disappears substantially, and appetite strengthens gradually, and sleep improves.The clothes Chinese medicine composition of the present invention 2 months that continues, the patient can take food smoothly, no longer singultus and belch, facial ruddy, check: focus significantly reduces.Obeyed Chinese medicine composition of the present invention again 8 months, all disease knowing are removed, and the every index of health is extensive normal.
5, Chen, woman, 52 years old, teacher.
Patient in October, 1996 because of become thin, dysphagia, through examination in hospital, be diagnosed as carcinoma of gastric cardia, the row excision of being in hospital immediately, pathological replacement: adenocarcinoma.Postoperative carries out chemotherapy.In December, 1998 occurs dysphagia once more, tells mucus, symptom such as anemia, and weight loss is the postoperative cardiac carcinoma recurrence through hospital diagnosis, and the row radiotherapy is because of weak can not bearing stops.The patient body weakness adds the radiotherapy reaction, can not have a meal in more than 20 day, only depends on transfusion to earn a bare living.
Took Chinese medicine composition of the present invention 15, all diseases alleviate, and can advance a small amount of liquid food, and spirit takes a turn for the better.Continue and obeyed Chinese medicine composition of the present invention 1 month, dysphagia further alleviates, and mucus reduces, and diet is more preceding to increase the small amount of solid of can taking food food to some extent.Continue and obeyed Chinese medicine composition of the present invention 2 months, patient's feed is more smooth, no mucus, and anemia is significantly improved.It is surplus to obey Chinese medicine composition of the present invention 6 months again, and symptom almost disappears, and the patient lives normally.
6, poplar, woman, 69 years old, writer.
Sky surplus the interruption singultus 20, companion's dysphagia 11 days.Medical history: the patient discontinuity singultus occurs before the sky surplus 20, the companion feels sick, vomits, and it is uncomfortable to take food, and does not give attention.The food of taking food appears in the patient before 11 days, dysphagia, pain, idol has nauseating, vomiting, pantothenic acid, and hospital's row gastroscope shows: distal esophagus is cauliflower-like to the irregular protuberance of body of stomach antetheca mucosa, the surface is congested, mucosal erosion, and pathology shows: a small amount of suspicious adenocarcinoma cell is arranged in the stomach cardia mucosa.The upper digestive tract radiography shows: carcinoma of gastric cardia.
Took Chinese medicine composition of the present invention 10, various symptoms alleviate to some extent.The clothes Chinese medicine composition of the present invention 1 month that continues, dysphagia significantly alleviates, and pain disappears substantially, feels sick, vomiting, pantothenic acid end.Continue and obeyed Chinese medicine composition of the present invention 2 months, patient's feed is more smooth, and pain is ended, and check: focus significantly reduces.It is surplus August to obey Chinese medicine composition of the present invention again, and all diseases are removed entirely, and patient's dietetic life all near normal, is followed up a case by regular visits to so far, not recurrence.
7, Huang, man, 69 years old, peasant.
Patient's cause in March breast stomach upset, tired unable, loss of appetite, extremely anemia is in hospital, and is super through B, CT and gastrointestinal image, gastroscope and get the biopsy pathology chemical examination, be diagnosed as: cardiac malignant tumor at the bottom of the stomach belongs to poorly differentiated adenocarcinoma.Patient age is higher, and treatment does not undergo surgery.Beginning before the first quarter moon, the feed difficulty appears in the patient, and having a meal drinks water swallows serious pain, can't swallow, and health is become thin rapidly.
Took Chinese medicine composition of the present invention 10, remission can be advanced a little liquid foods smoothly.Continue and obeyed Chinese medicine composition of the present invention 1 month, can independently take food, swallow smoothly.The clothes Chinese medicine composition of the present invention 2 months that continues can also be not limited to rare plastic flow food normally by the three meals in a day feed, normal diet can, have rosy cheeks, the mental status is clearly better.It is surplus June to obey Chinese medicine composition of the present invention again, and symptom disappears substantially, and it is still alive to follow up a case by regular visits to so far the patient, and the daily life diet is normal.
8, Zhang, man, 67 years old, artist.
Increased the weight of 20 days because of dysphagia 8 months in 2006.Be diagnosed as carcinoma of gastric cardia October through radiography, endoscopy.And the excision of performing an operation, course of treatment of postoperative chemotherapy, can the influent stream food after leaving hospital, but health obviously descends.In June, 2007, the state of an illness increased the weight of, can not take food, and dysphagia, loss of appetite can only be drunk water or rare rice water, chokes with sobs after the influent stream of the being everlasting food, also with postural dizziness.Go to a doctor in local hospital, esophagoscopy and pathological replacement are diagnosed as the postoperative cardiac carcinoma recurrence.Because patient's body constitution is too poor, can't carry out chemotherapeutic treatment.Examine and see: patient's nutrition is poor, and spirit is poor, becomes thin, and is weak, and the feed difficulty is interrupted the mucoid secretions of vomiting white.
Took Chinese medicine composition of the present invention 15, symptom makes moderate progress.Continue and obeyed Chinese medicine composition of the present invention 1 month, patient's spirit is clearly better, and can advance the semi-fluid food, and muscle power has also obtained recovery, and the check recurrent focus obviously dwindles.Continue and obeyed Chinese medicine composition of the present invention 2 months, stable disease, the soft diet of can suitably taking food does not have phenomenons such as vomiting, and the mental status further takes a turn for the better, and the check recurrent focus continues to reduce.It is surplus half a year to obey Chinese medicine composition of the present invention again, and all diseases are removed entirely, and the check recurrent focus disappears, and weight in patients increases, and in high spirits, diet is normal.
Five, therapeutic outcome:
In the 105 routine cases of being accepted for medical treatment,, wherein cure 13 examples through treatment in 9 months, produce effects 47 examples, effective 34 examples, invalid 11 examples, total effective rate reaches 89 %.The result shows that Chinese medicine composition of the present invention has extremely significant curative effect to treatment carcinoma of gastric cardia patient.
Claims (4)
1. Chinese medicine composition for the treatment of carcinoma of gastric cardia, it is characterized in that: the weight portion of each crude drug is:
30 parts of Lignum Dalbergiae Odoriferaes, 15 parts of Lignum Aquilariae Resinatum, 20 parts of Rhizoma Chuanxiongs, 30 parts of the Radix Aucklandiae, 50 parts of Pericarpium Citri Reticulataes, 50 parts in Poria, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 20 parts of Indigo Naturaliss, 20 parts of Herba Andrographis, 20 parts of Herba Lobeliae Chinensis, 20 parts of Herba Patriniae, 15 parts of Eupolyphaga Seu Steleophagas, 20 parts of Squama Maniss, 15 parts of Hirudos, 30 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Coptidis, 30 parts of Flos Loniceraes, 20 parts of Herba Violaes, 20 parts of Rhizoma Belamcandae, 50 parts of Radix Sophorae Tonkinensiss, 20 parts in Talcum, 30 parts of Rhizoma Acori Graminei, 30 parts of Fructus Aurantii Immaturuss, 20 parts in Radix Rubiae, 15 parts in catechu, 15 parts of Rhizoma Zingiberiss, 10 parts of Herba Menthaes, 50 parts of Radix Puerariaes, 15 parts of Folium Sennae, 20 parts of Aloes, 30 parts of the Radix Paeoniae Albas, 15 parts in Semen Persicae, 15 parts on Flos Carthami, 15 parts of rhizoma sparganic, 15 parts of Rhizoma Curcumae, 50 parts of Semen Coiciss, 20 parts of Pollen Typhaes, 30 parts of Radix Notoginseng, 15 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 parts of Nodus Nelumbinis Rhizomatis, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Herba Lycopi, 20 parts of Semen Vaccariae, 10 parts of Flos Chrysanthemis.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that: the method for Chinese medicinal according to routine is prepared into any oral formulations commonly used.
3. according to the described Chinese medicine composition of claim 2, it is characterized in that: described oral formulations is pill, capsule, tablet, powder, granule or oral liquid.
4. the application of any described Chinese medicine composition of claim 1～3 in preparation treatment carcinoma of gastric cardia medicine.
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| CN102920855B (en) * | 2012-11-27 | 2014-03-12 | 刘少利 | Traditional Chinese medicine for treating cancers |
| RU2507599C1 (en) * | 2012-12-12 | 2014-02-20 | Федеральное государственное бюджетное учреждение "Российский онкологический научный центр имени Н.Н. Блохина" Российской академии медицинских наук (ФГБУ "РОНЦ им. Н.Н. Блохина" РАМН) | Method for prevention of tumour development in experimental animals with high-frequency spontaneous tumour formation |
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| CN1947769A (en) * | 2005-10-11 | 2007-04-18 | 马斌 | Medicine for treating esophagus cancer and cardia cancer and its prepn. method |
| CN101249245A (en) * | 2006-12-26 | 2008-08-27 | 徐婧琳 | Medicament for curing esophagus cancer and cardiac cancer |
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| CN1947769A (en) * | 2005-10-11 | 2007-04-18 | 马斌 | Medicine for treating esophagus cancer and cardia cancer and its prepn. method |
| CN101249245A (en) * | 2006-12-26 | 2008-08-27 | 徐婧琳 | Medicament for curing esophagus cancer and cardiac cancer |
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| Title |
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| 刘汉举等.中药加介入治疗中晚期贲门癌60例临床观察.《浙江中西医结合杂志》.2003,第13卷(第1期),34-35. * |
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