CN104147522A - Pharmaceutical composition for treating upper gastrointestinal hemorrhage - Google Patents
Pharmaceutical composition for treating upper gastrointestinal hemorrhage Download PDFInfo
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- CN104147522A CN104147522A CN201410409862.XA CN201410409862A CN104147522A CN 104147522 A CN104147522 A CN 104147522A CN 201410409862 A CN201410409862 A CN 201410409862A CN 104147522 A CN104147522 A CN 104147522A
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Abstract
The invention relates to a pharmaceutical composition for treating upper gastrointestinal hemorrhage, which comprises the following medicinal materials by weight: 1-15 parts of Poria cocos, 5-20 parts of glehnia root, 1-5 parts of sargentodoxa vine, 10-30 parts of Pteris multifda poir, 1-10 parts of patrinia herb, 1-10 parts of Himalayan teasel root, 5-15 parts of Taxillus limprichtii, 1-5 parts of curcuma rhizome, 1-10 parts of coix seeds, 5-20 parts of Parthenocissus laetevirens Rehd, 1-15 parts of Menyanthes trifoliate, 1-15 parts of tarragon, 1-20 parts of oreas, 1-9 parts of corydalis tuber, 10-30 parts of Chinese pholidota herb, 1-10 parts of licorice and 5-20 parts of saruma root. The pharmaceutical composition for treating upper gastrointestinal hemorrhage selects a traditional Chinese medicinal materials formula with high-quality, and has the efficacy of clearing heat, cooling blood, reinforcing spleen and stomach, reducing phlegm and smoothening intestines, has remarkable curative effects on upper gastrointestinal hemorrhage, and is convenient to take, good in absorption effect, short in treatment course, rapid to take the effect into play, free of toxic or side effect, high in security and worthy of wide clinical popularization and application.
Description
Technical field
The present invention relates to medical domain, relate in particular to a kind of pharmaceutical composition for the treatment of upper gastrointestinal hemorrhage.
Background technology
Upper gastrointestinal hemorrhage refers to digestive tract more than Qu Shi ligament, comprise that esophagus, Stomach duodenum and pancreas, liver, bile duct diseases cause hemorrhage, show as hematemesis or melena, anemia, the peripheral circulatory failure causing with hypovolemia, with the greatly feature of urgency and (or) amount of bleeding of falling ill, the oncoming force is swift and violent, the state of an illness is dangerous, case fatality rate reaches more than 40%, as treatment not in time, can cause serious consequence because shock occurs in acute massive hemorrhage.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of upper gastrointestinal hemorrhage.
In order to solve the problems of the technologies described above, the invention provides a kind of pharmaceutical composition for the treatment of upper gastrointestinal hemorrhage.
Technical scheme of the present invention is as follows: a kind of pharmaceutical composition for the treatment of upper gastrointestinal hemorrhage, the medical material that it comprises following weight portion: Poria 1-15 part, Radix Glehniae 5-20 part, Caulis Sargentodoxae 1-5 part, Herba Cheilanthes chusane 10-30 part, Herba Patriniae 1-10 part, Radix Dipsaci 1-10 part, the parasitic 5-15 part of Drymotaenium miyoshianum (Mak.) Mak., Rhizoma Curcumae 1-5 part, Semen Coicis 1-10 part, five leaf wall rattan 5-20 parts, Herba menyanthis 1-15 part, Folium Artemisiae Argyi 1-10 part, Oreas martiana (Hopp. Et Hornsch.) Brid. 1-20 part, Rhizoma Corydalis 1-9 part, Pseudobulbus Pholidotae Chinensis 10-30 part, Radix Glycyrrhizae 1-10 part and Impatiens leptocaulon Hook.f. 5-20 part.
Preferably, the medical material that the pharmaceutical composition of described treatment upper gastrointestinal hemorrhage comprises following weight portion: 9 parts of parasitic 8 parts of 9 parts, Poria, 6 parts of Radix Glehniaes, 3 parts of Caulis Sargentodoxaes, 15 parts of Herba Cheilanthes chusanes, 5 parts of Herba Patriniae, 7 parts of Radix Dipsacis, Drymotaenium miyoshianum (Mak.) Mak., 3 parts of Rhizoma Curcumae, 4 parts of Semen Coiciss, five 9 parts, leaf wall rattans, 10 parts of Herba menyanthiss, 6 parts of Folium Artemisiae Argyis, 10 parts of Oreas martiana (Hopp. Et Hornsch.) Brid., 5 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Pholidotae Chinensis, 6 parts, Radix Glycyrrhizae and Impatiens leptocaulon Hook.f.s.
Preferably, the medical material that the pharmaceutical composition of described treatment upper gastrointestinal hemorrhage comprises following weight portion: 20 parts of parasitic 5 parts of 1 part, Poria, 20 parts of Radix Glehniaes, 1 part of Caulis Sargentodoxae, 30 parts of Herba Cheilanthes chusanes, 1 part of Herba Patriniae, 10 parts of Radix Dipsacis, Drymotaenium miyoshianum (Mak.) Mak., 5 parts of Rhizoma Curcumae, 10 parts of Semen Coiciss, five 5 parts, leaf wall rattans, 15 parts of Herba menyanthiss, 1 part of Folium Artemisiae Argyi, 20 parts of Oreas martiana (Hopp. Et Hornsch.) Brid., 1 part of Rhizoma Corydalis, 30 parts of Pseudobulbus Pholidotae Chinensis, 1 part, Radix Glycyrrhizae and Impatiens leptocaulon Hook.f.s.
Preferably, the medical material that the pharmaceutical composition of described treatment upper gastrointestinal hemorrhage comprises following weight portion: 16 parts of parasitic 12 parts of 15 parts, Poria, 5 parts of Radix Glehniaes, 4 parts of Caulis Sargentodoxaes, 20 parts of Herba Cheilanthes chusanes, 5 parts of Herba Patriniae, 7 parts of Radix Dipsacis, Drymotaenium miyoshianum (Mak.) Mak., 2 parts of Rhizoma Curcumae, 6 parts of Semen Coiciss, five 13 parts, leaf wall rattans, 11 parts of Herba menyanthiss, 4 parts of Folium Artemisiae Argyis, 17 parts of Oreas martiana (Hopp. Et Hornsch.) Brid., 6 parts of Rhizoma Corydalis, 22 parts of Pseudobulbus Pholidotae Chinensis, 4 parts, Radix Glycyrrhizae and Impatiens leptocaulon Hook.f.s.
Preferably, described pharmaceutical composition can be oral formulations, tablet, capsule, granule, powder or decoction.
In prescription of the present invention: Pseudobulbus Pholidotae Chinensis is monarch drug; Poria, Radix Glehniae, Herba Cheilanthes chusane, Herba Patriniae, Drymotaenium miyoshianum (Mak.) Mak. parasitism, five leaf wall rattans, Rhizoma Corydalis are ministerial drug; Caulis Sargentodoxae, Radix Dipsaci, Rhizoma Curcumae, Semen Coicis, Herba menyanthis, Folium Artemisiae Argyi, Oreas martiana (Hopp. Et Hornsch.) Brid., Impatiens leptocaulon Hook.f. are adjuvant drug; Radix Glycyrrhizae is for making medicine, coordinating the actions of various ingredients in a prescription.Can complement each other through the above medical material of clinical verification, play altogether the merit of monarch, there is clearing away heat and cooling blood, invigorating the spleen and regulating the stomach, effect of the sharp intestinal that reduces phlegm, treatment upper gastrointestinal hemorrhage is had to significant therapeutic effect, taking convenience, good absorbing effect, and short treating period, instant effect, without any side effects, security performance is high, is worth wide popularization and application clinically.
Detailed description of the invention
Be understandable that, although the present invention discloses as above with preferred embodiment, but above-described embodiment is not in order to limit the present invention.For any those of ordinary skill in the art, do not departing from technical solution of the present invention scope situation, all can utilize the technology contents of above-mentioned announcement to make many possible variations and modification to technical solution of the present invention, or be revised as the equivalent embodiment of equivalent variations.Therefore, every content that does not depart from technical solution of the present invention,, all still belongs in the scope of technical solution of the present invention protection any simple modification made for any of the above embodiments, equivalent variations and modification according to technical spirit of the present invention.
Embodiment decoction of the present invention
Take 9 grams of parasitic 8 grams of 9 grams, Poria, 6 grams of Radix Glehniaes, 3 grams of Caulis Sargentodoxaes, 15 grams of Herba Cheilanthes chusanes, 5 grams of Herba Patriniae, 7 grams of Radix Dipsacis, Drymotaenium miyoshianum (Mak.) Mak., 3 grams of Rhizoma Curcumae, 4 grams of Semen Coiciss, five 9 grams, leaf wall rattans, 10 grams of Herba menyanthiss, 6 grams of Folium Artemisiae Argyis, 10 grams of Oreas martiana (Hopp. Et Hornsch.) Brid., 5 grams of Rhizoma Corydalis, 15 grams of Pseudobulbus Pholidotae Chinensis, 6 grams, Radix Glycyrrhizae and Impatiens leptocaulon Hook.f.s, pulverize, cross 60 mesh sieves, add 5000 ml waters, under the condition refluxing, heat 3 hours, filter, filtrate is concentrated into 1000 milliliters, be cooled to room temperature, obtain final product.
Experimental example
Select in December, 2012 to 2014 year March in medical Patients with Upper Gastrointestinal Hemorrhage 48 examples of hospital outpatient, before treatment all there is positive findings or with vomiting in occult blood test, all with performances such as dizzy, weak, cardiopalmus, the esophageal varix wherein being caused by liver cirrhosis hemorrhage 31 examples of breaking, gastric ulcer is accompanied hemorrhage 13 examples, and duodenal bulbar ulcer is accompanied hemorrhage 4 examples.Be divided into two groups, each 24 examples, observation group's 24 examples, male 12 examples, female's 12 examples, age 33-70 year, average 43.1 years old.Matched group 24 examples, male 10 examples, female's 14 examples, age 32-70 year, average 43.3 years old.The aspect comparisons such as two groups of Genders, age, amount of bleeding, difference not statistically significant (P>0.05), has comparability.
Matched group oral omeprazole 0.4g every day, observation group every day twice, 200 milliliters of the decoctions of preparing in each oral embodiment.
According to (Zeng Minde. the prevention of esophagus gastropathy variceal bleeding and treatment countermeasure [J]. Chinese Journal of Hepatology, 2008,6 (2): 65-66.) formulate curative effect determinate standard.Effective: 24h stops hemorrhage, clinical manifestation is vital signs stable; Effective: the rear 48-72h for the treatment of stops hemorrhage, and blood pressure heart rate is steady, invalid: still hemorrhage after treatment 72h.With effective, effectively add up to total effectively.
Statistical procedures
Numerical data represents with rate, adopts χ
2inspection, P<0.05 is that difference has statistical significance.
Result
Therapeutic outcome is in table 1.
Table 1 observation group and the comparison of matched group curative effect [example (%)]
Note: with matched group comparison, * P<0.05.
Claims (5)
1. treat the pharmaceutical composition of upper gastrointestinal hemorrhage for one kind, it is characterized in that the medical material that it comprises following weight portion: Poria 1-15 part, Radix Glehniae 5-20 part, Caulis Sargentodoxae 1-5 part, Herba Cheilanthes chusane 10-30 part, Herba Patriniae 1-10 part, Radix Dipsaci 1-10 part, the parasitic 5-15 part of Drymotaenium miyoshianum (Mak.) Mak., Rhizoma Curcumae 1-5 part, Semen Coicis 1-10 part, five leaf wall rattan 5-20 parts, Herba menyanthis 1-15 part, Folium Artemisiae Argyi 1-10 part, Oreas martiana (Hopp. Et Hornsch.) Brid. 1-20 part, Rhizoma Corydalis 1-9 part, Pseudobulbus Pholidotae Chinensis 10-30 part, Radix Glycyrrhizae 1-10 part and Impatiens leptocaulon Hook.f. 5-20 part.
2. the pharmaceutical composition for the treatment of upper gastrointestinal hemorrhage according to claim 1, it is characterized in that the medical material that it comprises following weight portion: 9 parts of parasitic 8 parts of 9 parts, Poria, 6 parts of Radix Glehniaes, 3 parts of Caulis Sargentodoxaes, 15 parts of Herba Cheilanthes chusanes, 5 parts of Herba Patriniae, 7 parts of Radix Dipsacis, Drymotaenium miyoshianum (Mak.) Mak., 3 parts of Rhizoma Curcumae, 4 parts of Semen Coiciss, five 9 parts, leaf wall rattans, 10 parts of Herba menyanthiss, 6 parts of Folium Artemisiae Argyis, 10 parts of Oreas martiana (Hopp. Et Hornsch.) Brid., 5 parts of Rhizoma Corydalis, 15 parts of Pseudobulbus Pholidotae Chinensis, 6 parts, Radix Glycyrrhizae and Impatiens leptocaulon Hook.f.s.
3. the pharmaceutical composition for the treatment of upper gastrointestinal hemorrhage according to claim 1, it is characterized in that the medical material that it comprises following weight portion: 20 parts of parasitic 5 parts of 1 part, Poria, 20 parts of Radix Glehniaes, 1 part of Caulis Sargentodoxae, 30 parts of Herba Cheilanthes chusanes, 1 part of Herba Patriniae, 10 parts of Radix Dipsacis, Drymotaenium miyoshianum (Mak.) Mak., 5 parts of Rhizoma Curcumae, 10 parts of Semen Coiciss, five 5 parts, leaf wall rattans, 15 parts of Herba menyanthiss, 1 part of Folium Artemisiae Argyi, 20 parts of Oreas martiana (Hopp. Et Hornsch.) Brid., 1 part of Rhizoma Corydalis, 30 parts of Pseudobulbus Pholidotae Chinensis, 1 part, Radix Glycyrrhizae and Impatiens leptocaulon Hook.f.s.
4. the pharmaceutical composition for the treatment of upper gastrointestinal hemorrhage according to claim 1, it is characterized in that the medical material that it comprises following weight portion: 16 parts of parasitic 12 parts of 15 parts, Poria, 5 parts of Radix Glehniaes, 4 parts of Caulis Sargentodoxaes, 20 parts of Herba Cheilanthes chusanes, 5 parts of Herba Patriniae, 7 parts of Radix Dipsacis, Drymotaenium miyoshianum (Mak.) Mak., 2 parts of Rhizoma Curcumae, 6 parts of Semen Coiciss, five 13 parts, leaf wall rattans, 11 parts of Herba menyanthiss, 4 parts of Folium Artemisiae Argyis, 17 parts of Oreas martiana (Hopp. Et Hornsch.) Brid., 6 parts of Rhizoma Corydalis, 22 parts of Pseudobulbus Pholidotae Chinensis, 4 parts, Radix Glycyrrhizae and Impatiens leptocaulon Hook.f.s.
5. the pharmaceutical composition for the treatment of upper gastrointestinal hemorrhage according to claim 1, is characterized in that, described pharmaceutical composition can be oral formulations, tablet, capsule, granule, powder or decoction.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106215042A (en) * | 2016-08-31 | 2016-12-14 | 安徽省润生医药股份有限公司 | The treatment pharmaceutical composition of upper gastrointestinal hemorrhage, its preparation method and preparation |
Citations (2)
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CN101757602A (en) * | 2010-04-07 | 2010-06-30 | 泰一和浦(北京)中医药研究院有限公司 | Traditional Chinese medicine composition for treating cardiac carcinoma and preparation method thereof |
CN103845673A (en) * | 2014-03-20 | 2014-06-11 | 张小丽 | Medicine for treating upper gastrointestinal hemorrhage and preparation method thereof |
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2014
- 2014-08-19 CN CN201410409862.XA patent/CN104147522A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101757602A (en) * | 2010-04-07 | 2010-06-30 | 泰一和浦(北京)中医药研究院有限公司 | Traditional Chinese medicine composition for treating cardiac carcinoma and preparation method thereof |
CN103845673A (en) * | 2014-03-20 | 2014-06-11 | 张小丽 | Medicine for treating upper gastrointestinal hemorrhage and preparation method thereof |
Non-Patent Citations (2)
Title |
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潘炳森: "中医药治疗上消化道出血近况", 《湖南中医杂志》 * |
黄国华: "中药泻心汤联合奥美拉唑治疗上消化道出血24例", 《中国药业》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106215042A (en) * | 2016-08-31 | 2016-12-14 | 安徽省润生医药股份有限公司 | The treatment pharmaceutical composition of upper gastrointestinal hemorrhage, its preparation method and preparation |
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Application publication date: 20141119 |