CN101773647B - Chinese medicine composition for treating duodenal carcinoma and preparation method thereof - Google Patents
Chinese medicine composition for treating duodenal carcinoma and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicine composition for treating duodenal carcinoma and a preparation method thereof. The Chinese medicine composition is mainly formed by the following raw medicine materials: indigo naturalis, coix seed, Poria cocos, white atractylodes rhizome, rosewood heart wood, storax, rheum officinale, rhizoma corydalis, prepared frankincense, prepared myrrh, common burreed rhizome, zedoary, lightyellow sophora root, prepared rehmannia root, sangusis draconis, Taraxacum officinale root, Chinese violet, lithospermum, heartleaf houttuynia herb, Chinese lobelia, bunge cherry seed, Mangnolia officinalis, immature bitter orange, agilawood and the like. The Chinese medicine composition of the invention can be prepared into any kind of common oral preparation according to the conventional Chinese medicine preparation method. The invention has the advantages that symptoms such as nausea, sickness, abdominal distension, irregular epigastric zone pain, pyloric obstruction, melena, emaciation, weight reduction and the like are obviously improved, the clinical curative effect is exact, the curative effect is obvious and the rapid effect is obtained. Moreover, the Chinese medicine composition is basically combined by homologous plant food medicines regulated in National Formulary, thereby having the advantages of low cost, basically no toxic side effect and the like.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition for the treatment of duodenal carcinoma.Relating in particular to a kind of is the Chinese medicine composition and preparation method thereof of the treatment duodenal carcinoma of crude drug with the Chinese herbal medicine.
Background technology
Duodenal carcinoma is the disease of a kind of etiology unknown, difficult diagnosis, account for 0.4%～1.8% of malignant tumor of digestive tract, with nauseating, vomiting, abdominal distention, upper abdomen irregularities pain, pyloric obstruction, melena, become thin and lose weight etc. is main clinical manifestation, similar to duodenal ulcer, sour medicine can not alleviating pain but feed reaches.Be the poorest person of prognosis in other various malignant tumor of duodenum, seldom have to surpass 5 years existent reports that its sickness rate is and increases trend.
Excision is that to treat the constitutional duodenal carcinoma at present the most basic, effective method, but the complication that postoperative may occur is a lot, the treatment side effect is big, the relapse and metastasis probability is very high, survival rate is low, often falls flat delay treatment, can not find suitable Therapeutic Method, in order to overcome above-mentioned defective, the present invention is based on the differential diagnosis of diseases and the dialectical principle that combines, treating both the principal and secondary aspects of a disease of Chinese traditional treatment duodenal carcinoma, deficiency and excess is also controlled, inside and outside logical the accent, emergency is taken in concurrently, filters out dispersing the stagnated liver-QI for regulating the stomach, hard masses softening and resolving, the granulation promoting of regulating the flow of vital energy, the natural plant of hemostasia and dissipation blood stasis, according to the theory of Chinese medical science prescription, be prepared from according to certain weight proportion.A kind of Chinese medicine composition of evident in efficacy, with low cost, treatment duodenal carcinoma that toxic and side effects is minimum is provided.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage forms, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be: pill, capsule, tablet, powder, granule or oral liquid etc.
Summary of the invention
Technical problem to be solved by this invention is assorted to overcome above-described shortcoming, and a kind of Chinese medicine composition of treatment duodenal carcinoma of evident in efficacy, with low cost, almost non-toxic side effect is provided.
The technical problem of the desired solution of the present invention realizes by following technological approaches.
A kind of Chinese medicine composition for the treatment of duodenal carcinoma of the present invention, the component of main following weight portion is formed:
1～100 part of Indigo Naturalis, 1～100 part of Semen Coicis, 1～300 part in Poria, 1～120 part of the Rhizoma Atractylodis Macrocephalae, 1～120 part of Lignum Dalbergiae Odoriferae, 1～100 part of Styrax, 1～100 part of Herba Lysimachiae foenum-graeci, 1～100 part of Radix Et Rhizoma Rhei, 1～120 part of Rhizoma Corydalis, 1～50 part of Olibanum (processed), 1～50 part of Myrrha (processed), 1～50 part of RHZOMA SPARGANII, 1～50 part of Rhizoma Curcumae, 1～120 part in Radix Rubiae, 1～120 part of Massa Medicata Fermentata, 1～120 part of Semen Arecae Prepareta, 1～120 part in Fructus Hordei Germinatus, 1～100 part of Lignum Sappan, 1～50 part of Sanguis Draxonis, 1～120 part of Herba Taraxaci, 1～100 part of Herba Violae, 1～120 part of Herba Patriniae, 1～120 part of Radix Trichosanthis, 1～100 part of Radix Scutellariae, 1～100 part of Rhizoma Coptidis, 1～120 part of favus skin, 1～120 part of Cortex Lycii, 1～120 part of Radix Arnebiae (Radix Lithospermi), 1～120 part of Herba Houttuyniae, 1～120 part of Radix Sophorae Tonkinensis, 1～150 part of Herba Lobeliae Chinensis, 1～100 part of Fructus Aurantii Immaturus, 1～50 part of Lignum Aquilariae Resinatum, 1～100 part of Rhizoma Chuanxiong, 1～300 part of Rhizoma Cyperi, 1～50 part of Eupolyphaga Seu Steleophaga, 1～50 part of Sanguis Draxonis, process 1～50 part of Hirudo, process 1～50 part of Tabanus.
Be preferably:
20 parts of Indigo Naturaliss, 50 parts of Semen Coiciss, 100 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Lignum Dalbergiae Odoriferaes, 20 parts of Styrax, 20 parts of Herba Lysimachiae foenum-graeci, 15 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Corydalis, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 15 parts of RHZOMA SPARGANII, 15 parts of Rhizoma Curcumae, 20 parts in Radix Rubiae, 30 parts of Massa Medicata Fermentata, 15 parts of Semen Arecae Preparetas, 30 parts in Fructus Hordei Germinatus, 20 parts of Lignum Sappans, 10 parts of Sanguis Draxonis, 15 parts of Herba Taraxaci, 15 parts of Herba Violaes, 20 parts of Herba Patriniae, 30 parts of Radix Trichosanthis, 20 parts of Radix Scutellariaes, 15 parts of Rhizoma Coptidis, 20 parts of favus skins, 30 parts of Cortex Lycii, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Herba Houttuyniae, 20 parts of Radix Sophorae Tonkinensiss, 30 parts of Herba Lobeliae Chinensis, 30 parts of Fructus Aurantii Immaturuss, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Rhizoma Chuanxiongs, 100 parts of Rhizoma Cyperis, 15 parts of Eupolyphaga Seu Steleophagas, 10 parts of Sanguis Draxonis, process 15 parts of Hirudos, process 15 parts of Tabanuss.
The weight portion consumption of each component of Chinese medicine composition of the present invention can also be:
1～120 part of Pseudobulbus Cremastrae Seu Pleiones, 1～100 part of Radix Stellariae, 1～100 part of Semen Pruni, 1～120 part of the Radix Paeoniae Alba, 1～100 part of Radix Paeoniae Rubra, 1～100 part of Cortex Magnoliae Officinalis, 1～100 part of Fructus Amomi, 1～100 part of Rhizoma Atractylodis, 1～50 part of Semen Alpiniae Katsumadai, 1～50 part of Fructus Tsaoko, 1～120 part of Cortex Periplocae, 1～50 part of Fructus Foeniculi, 1～50 part of Rhizoma Zingiberis, 1～100 part of Rhizoma Polygoni Cuspidati, 1～120 part of Radix Sophorae Flavescentis, 1～100 part of Radix Rehmanniae Preparata, 1～100 part of Radix Scrophulariae, process 1～50 part of Squama Manis, 1～100 part of Endothelium Corneum Gigeriae Galli, 1～100 part of the Radix Linderae, 1～100 part of Bulbus Allii Macrostemonis, 1～50 part of Aspongopus, 1～100 part of Semen Raphani.
Be preferably:
20 parts of Pseudobulbus Cremastrae Seu Pleioness, 20 parts of Radix Stellariaes, 15 parts of Semen Prunis, 30 parts of the Radix Paeoniae Albas, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Amomis, 15 parts of Rhizoma Atractylodis, 15 parts of Semen Alpiniae Katsumadai, 10 parts of Fructus Tsaokos, 20 parts of Cortex Periplocaes, 10 parts of Fructus Foeniculi, 15 parts of Rhizoma Zingiberiss, 15 parts of Rhizoma Polygoni Cuspidati, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Rehmanniae Preparata, 20 parts of Radix Scrophulariaes, process 15 parts of Squama Manis, 20 parts of Endothelium Corneum Gigeriae Galli, 30 parts of the Radixs Linderae, 20 parts of Bulbus Allii Macrostemonis, 15 parts of Aspongopuss, 20 parts of Semen Raphanis.
Above-mentioned Chinese medicine composition of the present invention adds various conventional adjuvant required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc. are prepared into any oral formulations commonly used with the method for Chinese medicinal of routine, for example can be pill, capsule, tablet, powder, granule or oral liquid etc.
Chinese medicine composition of the present invention is opened one's minds based on traditional Chinese medical science the five internal organs differentiation of syndromes of YIN and YANG guiding principle, in conjunction with safe one and Pu innovation theory system " ten thousand diseases ascent theory ", " the five internal organs differentiation of syndromes of YIN and YANG guiding principle ", " three-dimensional conservation regulation and control rule " and clinical treatment " pairing principle " are as instructing, take place in conjunction with disease, development and the rule that changes, classify according to the original new drug system, formation is monarch with " the five internal organs basic function is adjusted; equilibrium between yin and yang coordination side ", " the main pathogenesis of the five internal organs adjustment side " is minister, " therapy of serious disease side " is assistant, " clinical fundamental symptoms symptomatic treatment side " Chinese medicine patent medicine " original new drug system " for making.
The used herbal raw material medicine of the present invention all can be buied from the Chinese medicine shop, and its specification meets national medical standard.
Usage and dosage: dosage of the present invention depends on concrete dosage form, factors such as patient age, body weight, health status.As guidance: for oral administration: 1) capsule: obey 2～5 every day three times at every turn, every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.5) powder: every day three times, each 2～4 grams, warm water takes.
The treatment that the present invention is directed to the duodenal carcinoma patient is very effective, various crude drug are coordinated mutually can play together and are at utmost brought into play drug effect, can effectively improve the self-coordination ability of patient's body, significantly improve function and clinical subjective symptoms, have advantage such as have no side effect, expense is lower in addition.
The specific embodiment
Further describe the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never are limited to the present invention.
The preparation of [embodiment 1] capsule
Take by weighing each raw material by following weight portion: 20 parts of Indigo Naturaliss, 50 parts of Semen Coiciss, 100 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Lignum Dalbergiae Odoriferaes, 20 parts of Styrax, 20 parts of Herba Lysimachiae foenum-graeci, 15 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Corydalis, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 15 parts of RHZOMA SPARGANII, 15 parts of Rhizoma Curcumae, 20 parts in Radix Rubiae, 30 parts of Massa Medicata Fermentata, 15 parts of Semen Arecae Preparetas, 30 parts in Fructus Hordei Germinatus, 20 parts of Lignum Sappans, 10 parts of Sanguis Draxonis, 15 parts of Herba Taraxaci, 15 parts of Herba Violaes, 20 parts of Herba Patriniae, 30 parts of Radix Trichosanthis, 15 parts of Rhizoma Coptidis, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Herba Houttuyniae, 20 parts of Radix Sophorae Tonkinensiss, 30 parts of Herba Lobeliae Chinensis, 30 parts of Fructus Aurantii Immaturuss, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Rhizoma Chuanxiongs, 100 parts of Rhizoma Cyperis, 15 parts of Eupolyphaga Seu Steleophagas, 10 parts of Sanguis Draxonis, 30 parts of the Radix Paeoniae Albas, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Amomis, 15 parts of Rhizoma Atractylodis, 15 parts of Rhizoma Zingiberiss, 15 parts of Rhizoma Polygoni Cuspidati, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Rehmanniae Preparata, 20 parts of Radix Scrophulariaes, process 15 parts of Squama Manis, 20 parts of Endothelium Corneum Gigeriae Galli, 30 parts of the Radixs Linderae, 20 parts of Bulbus Allii Macrostemonis, 15 parts of Aspongopuss, 20 parts of Semen Raphanis.
Grind into after each component mixing with above-mentioned weight and incapsulate promptly after fine powder is crossed 1500 mesh sieves.
The preparation of [embodiment 2] granule
Take by weighing each raw material by following weight portion: 20 parts of Indigo Naturaliss, 50 parts of Semen Coiciss, 100 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Lignum Dalbergiae Odoriferaes, 20 parts of Styrax, 20 parts of Herba Lysimachiae foenum-graeci, 15 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Corydalis, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 15 parts of RHZOMA SPARGANII, 15 parts of Rhizoma Curcumae, 20 parts in Radix Rubiae, 30 parts of Massa Medicata Fermentata, 15 parts of Semen Arecae Preparetas, 30 parts in Fructus Hordei Germinatus, 20 parts of Lignum Sappans, 10 parts of Sanguis Draxonis, 15 parts of Herba Taraxaci, 15 parts of Herba Violaes, 20 parts of Herba Patriniae, 30 parts of Radix Trichosanthis, 15 parts of Rhizoma Coptidis, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Herba Houttuyniae, 20 parts of Radix Sophorae Tonkinensiss, 30 parts of Herba Lobeliae Chinensis, 30 parts of Fructus Aurantii Immaturuss, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Rhizoma Chuanxiongs, 100 parts of Rhizoma Cyperis, 15 parts of Eupolyphaga Seu Steleophagas, 10 parts of Sanguis Draxonis, 30 parts of the Radix Paeoniae Albas, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Amomis, 15 parts of Rhizoma Atractylodis, 15 parts of Rhizoma Zingiberiss, 15 parts of Rhizoma Polygoni Cuspidati, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Rehmanniae Preparata, 20 parts of Radix Scrophulariaes, process 15 parts of Squama Manis, 20 parts of Endothelium Corneum Gigeriae Galli, 30 parts of the Radixs Linderae, 20 parts of Bulbus Allii Macrostemonis, 15 parts of Aspongopuss, 20 parts of Semen Raphanis.
Each raw material of above-mentioned weight fraction is mixed, after grinding into fine powder and crossing 1500 mesh sieves, add ethanol and make adhesive, add starch and do filler, be pressed into granule.
The preparation of [embodiment 3] tablet
Take by weighing each raw material by following weight portion: 20 parts of Indigo Naturaliss, 50 parts of Semen Coiciss, 100 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Lignum Dalbergiae Odoriferaes, 20 parts of Styrax, 20 parts of Herba Lysimachiae foenum-graeci, 15 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Corydalis, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 15 parts of RHZOMA SPARGANII, 15 parts of Rhizoma Curcumae, 20 parts in Radix Rubiae, 30 parts of Massa Medicata Fermentata, 15 parts of Semen Arecae Preparetas, 30 parts in Fructus Hordei Germinatus, 20 parts of Lignum Sappans, 10 parts of Sanguis Draxonis, 15 parts of Herba Taraxaci, 15 parts of Herba Violaes, 20 parts of Herba Patriniae, 30 parts of Radix Trichosanthis, 15 parts of Rhizoma Coptidis, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Herba Houttuyniae, 20 parts of Radix Sophorae Tonkinensiss, 30 parts of Herba Lobeliae Chinensis, 30 parts of Fructus Aurantii Immaturuss, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Rhizoma Chuanxiongs, 100 parts of Rhizoma Cyperis, 15 parts of Eupolyphaga Seu Steleophagas, 10 parts of Sanguis Draxonis, 30 parts of the Radix Paeoniae Albas, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Amomis, 15 parts of Rhizoma Atractylodis, 15 parts of Rhizoma Zingiberiss, 15 parts of Rhizoma Polygoni Cuspidati, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Rehmanniae Preparata, 20 parts of Radix Scrophulariaes, process 15 parts of Squama Manis, 20 parts of Endothelium Corneum Gigeriae Galli, 30 parts of the Radixs Linderae, 20 parts of Bulbus Allii Macrostemonis, 15 parts of Aspongopuss, 20 parts of Semen Raphanis.
Each raw material of above-mentioned weight portion is mixed, after grinding into fine powder and crossing 800～1200 order dusting covers, make tablet promptly.
The preparation of [embodiment 4] pill
Take by weighing each raw material by following weight portion: 20 parts of Indigo Naturaliss, 50 parts of Semen Coiciss, 100 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Lignum Dalbergiae Odoriferaes, 20 parts of Styrax, 20 parts of Herba Lysimachiae foenum-graeci, 15 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Corydalis, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 15 parts of RHZOMA SPARGANII, 15 parts of Rhizoma Curcumae, 20 parts in Radix Rubiae, 30 parts of Massa Medicata Fermentata, 15 parts of Semen Arecae Preparetas, 30 parts in Fructus Hordei Germinatus, 20 parts of Lignum Sappans, 10 parts of Sanguis Draxonis, 15 parts of Herba Taraxaci, 15 parts of Herba Violaes, 20 parts of Herba Patriniae, 30 parts of Radix Trichosanthis, 15 parts of Rhizoma Coptidis, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Herba Houttuyniae, 20 parts of Radix Sophorae Tonkinensiss, 30 parts of Herba Lobeliae Chinensis, 30 parts of Fructus Aurantii Immaturuss, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Rhizoma Chuanxiongs, 100 parts of Rhizoma Cyperis, 15 parts of Eupolyphaga Seu Steleophagas, 10 parts of Sanguis Draxonis, 30 parts of the Radix Paeoniae Albas, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Amomis, 15 parts of Rhizoma Atractylodis, 15 parts of Rhizoma Zingiberiss, 15 parts of Rhizoma Polygoni Cuspidati, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Rehmanniae Preparata, 20 parts of Radix Scrophulariaes, process 15 parts of Squama Manis, 20 parts of Endothelium Corneum Gigeriae Galli, 30 parts of the Radixs Linderae, 20 parts of Bulbus Allii Macrostemonis, 15 parts of Aspongopuss, 20 parts of Semen Raphanis.
Each raw material of above-mentioned weight is mixed, grind into cross 600～1000 mesh sieves behind the fine powder after, make pill promptly.
The preparation of [embodiment 5] oral liquid
Take by weighing each raw material by following weight portion: 20 parts of Indigo Naturaliss, 50 parts of Semen Coiciss, 100 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Lignum Dalbergiae Odoriferaes, 20 parts of Styrax, 20 parts of Herba Lysimachiae foenum-graeci, 15 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Corydalis, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 15 parts of RHZOMA SPARGANII, 15 parts of Rhizoma Curcumae, 20 parts in Radix Rubiae, 30 parts of Massa Medicata Fermentata, 15 parts of Semen Arecae Preparetas, 30 parts in Fructus Hordei Germinatus, 20 parts of Lignum Sappans, 10 parts of Sanguis Draxonis, 15 parts of Herba Taraxaci, 15 parts of Herba Violaes, 20 parts of Herba Patriniae, 30 parts of Radix Trichosanthis, 15 parts of Rhizoma Coptidis, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Herba Houttuyniae, 20 parts of Radix Sophorae Tonkinensiss, 30 parts of Herba Lobeliae Chinensis, 30 parts of Fructus Aurantii Immaturuss, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Rhizoma Chuanxiongs, 100 parts of Rhizoma Cyperis, 15 parts of Eupolyphaga Seu Steleophagas, 10 parts of Sanguis Draxonis, 30 parts of the Radix Paeoniae Albas, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Amomis, 15 parts of Rhizoma Atractylodis, 15 parts of Rhizoma Zingiberiss, 15 parts of Rhizoma Polygoni Cuspidati, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Rehmanniae Preparata, 20 parts of Radix Scrophulariaes, process 15 parts of Squama Manis, 20 parts of Endothelium Corneum Gigeriae Galli, 30 parts of the Radixs Linderae, 20 parts of Bulbus Allii Macrostemonis, 15 parts of Aspongopuss, 20 parts of Semen Raphanis.
Each raw material of above-mentioned weight is mixed, after three decoctions, three filtrates are mixed, filter, be concentrated into rule
Fixed concentration, put cold, the stock solution embedding, irradiation sterilization, after the check, packed products is made oral liquid promptly.
[experimental example] traditional Chinese medicine composition for treating duodenal carcinoma of the present invention patient's clinical observation on the therapeutic effect experiment
One, the physical data of experimental subject: adopt Chinese medicine composition of the present invention to treat 37 routine patients altogether, wherein male 21 examples, women 16 examples; The oldest person 76 years old, age reckling 30 years old.
Two, Therapeutic Method:
Usage and dosage: adopt the prepared medicament of the embodiment of the invention, its usage and consumption are as follows: 1) capsule: obey 2～5 every day three times at every turn, and every content of dispersion 0.4 gram, warm water takes.2) tablet: every day three times, each 2～4, every content of dispersion 0.5 gram, warm water takes.3) pill: every day three times, each 5 grams, warm water takes.4) granule: every day three times.Each 5 grams, warm water takes.5) powder: every day three times, each 2～4 grams, warm water takes.
The course of treatment: one month is a course of treatment, treats for 12 courses of treatment altogether.
Three, therapeutic evaluation standard
Cure: sign and symptom are improved fully, foci disappearance or basic the disappearance, and nothing spreads or shifts.
Produce effects: sign and symptom are significantly improved, and focus is significantly dwindled, and do not have new focus and form.
Effectively: sign and symptom have obvious change, and focus does not have and improves or with new focus.
Invalid: sign does not have change, symptom such as preceding or state of an illness sustainable development.
Four, model case:
1, Chen, woman, 38 years old, teacher.
Made a definite diagnosis duodenal carcinoma 2 months, generated heat two days.This trouble is being diagnosed as duodenal carcinoma two months ago, low grade fever repeatedly, and the highest 38.5 degree of body temperature, stomachache, in two cycles of chemotherapy, stomachache and heating are alleviated, leave hospital, heating once more before two days, the highest 38.0 degree of body temperature, the epigastrium distending pain, diarrhoea is felt sick, vomiting.
Took Chinese medicine composition of the present invention 7, body temperature is normal, and abdominal distention is alleviated.Continue and obeyed Chinese medicine composition of the present invention 20, abdominal distention continues to alleviate, and surplus disease alleviates.It is surplus to obey Chinese medicine composition JIUYUE of the present invention again, and symptom all disappears, and patient's life is normal substantially.
2, fourth, man, 45 years old, engineer.
Because of " middle upper abdomen feeling of distension and oppression, belch, acid regurgitation, about three months " goes to hospital's Digestive System Department to go to a doctor.Give symptomatic treatments such as antacid, mucosa protective agent one month, subjective symptoms does not have improvement, becomes thin, feels sick, vomits coffee-like liquid at the beginning of 12 months to be admitted to hospital once more, and the upper right abdomen of health check-up takes over and touches not removable enclosed mass.Gastroscope, CT examination: see about 5 * 4 * 5cm of the nearly gastric antrum of duodenum portion's tumor, block duodenal lumen and extend to lesser gastric curvature, diagnosis: duodenal carcinoma.
Took Chinese medicine composition of the present invention 10, all diseases alleviate.Continue and obeyed this Chinese medicine composition 1 month, feel sick and alleviate, vomiting ends, and check tumor and before reduce, about 3 * 2 * 4cm, spirit takes a turn for the better.It is surplus June to obey Chinese medicine composition of the present invention again, and the check tumor disappears substantially, and all diseases are all removed, and weight in patients increases by 5 kilograms, and life is normal.
3, go into business certain, woman, 72 years old, retired employees.
Because of abdominal distention, poor appetite, acid regurgitation 1 month, nearly 1 week increased the weight of to be admitted to hospital.The patient before 40 days the patient do not have clear and definite inducement and abdominal distention occurs, be full distention and fullness in the abdomen sense, reduce with slight angor of epigastrium and exhaust defecation, the belch acid regurgitation, the first beginning and end are noted, but symptom increases the weight of gradually, row's melena 1 time is through B ultrasonic, gastroscope, intestinal mirror, CT examination: the constitutional duodenal carcinoma.In 2 weeks of symptomatic treatment, symptom does not have alleviation and examines.
Took Chinese medicine composition of the present invention 15, abdominal distention is alleviated.Continue and obeyed Chinese medicine composition of the present invention 2 months, abdominal distention before continues to alleviate, and diet increases, and the defecation aerofluxus recovers.After obeying Chinese medicine composition JIUYUE of the present invention again, all normal, reexamine focus disappears, and weight in patients increases, and is in high spirits.
4, Zhao, man, 77 years old, peasant.
Healthy usually, beginning appetite reduces before March, begins to think and is warm, and has no appetite, and only eats half bowl of meal, and the patient has not felt like a meal at all now, only eats a little spoon meal every day and feels supportting yet.Be admitted to hospital through B ultrasonic, gastroscope, intestinal mirror, CT examination: malignant duodenal tumors, about 3.0 * 3.4 cm of size, older because of the patient, family members disagree with operation and chemotherapy, require treatment by Chinese herbs.
Took Chinese medicine composition of the present invention 15, diet has increase slightly.Continue and obeyed Chinese medicine composition of the present invention 1 month, the check tumor significantly reduces, about 1.3 * 2.2 cm, and appetite is approaching normal, the spirit improvement.It is surplus July to obey Chinese medicine composition of the present invention again, and the check tumor focus disappears substantially, and diet is normal, and in the past few years, situation is stable.
5, Lee so-and-so, man, 35 years old, cadre.
The irregular dull pain of patient's epigastrium 1 year increased the weight of one month, intermittent dull pain under beginning xiphoid-process the first half of the year, and with nauseating belch acid regurgitation water, pain is the acupuncture sample, pain relieved by pressing desire for hot drinks, poor appetite loose stool, time band black.Before before February in certain hospital, through B ultrasonic, gastroscope, intestinal mirror, CT examination: duodenal carcinoma, hospitalization.Nearly two weeks comes, and the state of an illness is control not, increases the weight of on the contrary.The patient becomes thin, the bitter taste poor appetite, and malaise, it is relatively poor to sleep, and expression is painful, tongue body obesity, white and greasy fur, deep-thready pulse.
Took Chinese medicine composition of the present invention 15, state of an illness basic controlling.Continue and obeyed Chinese medicine composition of the present invention 20, symptom is further alleviated, and diet increases, and spirit takes a turn for the better, and reexamine focus reduces.Continue and obeyed Chinese medicine composition of the present invention 1 month, pain disappears substantially, and it is gradually normal to defecate, and spirit continues to take a turn for the better, and reexamine focus continues to reduce.It is surplus August to obey Chinese medicine composition of the present invention again, and reexamine focus disappears, looks like the normal person, weight increase, and the patient fully recovers, and phone is ask and is visited, and does not see recurrence.
6, stone, man, 30 years old, driver.
The irregular pain of patient's readme discontinuity epigastrium 2 years is surplus.Existing epigastrium pain, the sore spot desire for warm and being pressed, the abdominal distention belch, body is tired weak, feels sick, vomiting, the hands and feet being not warm, shallow complexion, emaciated physique, stool is black, and loose stool every day 2～4 times, pale tongue is dark, white and thin fur, corpulent tongue is big, and indentation is seen on the limit, deep-thready pulse.Through B ultrasonic, gastroscope, intestinal mirror, CT examination: duodenal carcinoma.
Took Chinese medicine composition of the present invention 15, epigastrium pain, abdominal distention obviously alleviate, and melena disappears, but stool is still half congealed thin, day row 2～3 times.Continue and obeyed Chinese medicine composition of the present invention 1 month, symptoms such as epigastrium pain, abdominal distention, belch subtract greatly, feel sick, vomit and end, and the stool recovery is normal.Obeyed Chinese medicine composition of the present invention again 9 months, spirit, diet is all good, and two is just normal, no significant discomfort sense, prompting on inspection: the disappearance of duodenum focus, follow up a case by regular visits to after 1 year, and the patient lives normally.
7, often so-and-so, man, 34 years old, workman.
The main suit: epigastrium irregularities pain increased the weight of 1 month.Medical history: the patient once felt sick suddenly before August, acid regurgitation, abdominal distention, and epigastrium paroxysmal is had a pain, and is admitted to hospital by the duodenal ulcer symptomatic treatment, and the state of an illness day by day increases the weight of on the contrary.Again through B ultrasonic, gastroscope, intestinal mirror, CT examination: duodenal carcinoma.Body of the tongue is light red, and greasy fur is yellow does stringy and tense pulse.
Took Chinese medicine composition of the present invention 15, the epigastrium pain relief.Continue and obeyed Chinese medicine composition of the present invention 20, the epigastrium paroxysmal pain is not done, and abdominal distention subtracts greatly.Continue and obeyed Chinese medicine composition of the present invention 2 months, abdominal distention continues to alleviate, and acid regurgitation and vomiting stop.Obey Chinese medicine composition of the present invention again after 9 months, through checking gastroscope: the duodenum pathological changes disappears, and the patient is healed, does not follow up a case by regular visits to recurrence after 2 years.
8, Chen, woman, 36 years old, teacher.
Do 1 year during the irregular pain of epigastrium, increased the weight of 3 months.The patient sends out epigastrium pain over 1 year the time, increased the weight of in nearly three months, and general sometimes acid regurgitation water, the bitter taste xerostomia is become thin, and stool is black, is admitted to hospital and makes a definite diagnosis through B ultrasonic, gastroscope, intestinal mirror, CT examination: duodenal carcinoma.Red tongue, yellow and thin fur, wiry and frequent pulse.
Took Chinese medicine composition of the present invention 20, the epigastrium pain relief, acid regurgitation water reduces.Continue and obeyed Chinese medicine composition of the present invention 2 months, symptom is further alleviated, and diet increases, and spirit takes a turn for the better, and reexamine focus reduces.Continue and obeyed Chinese medicine composition of the present invention 3 months, epigastrium pain disappears substantially, does not have general acid regurgitation water, the xerostomia sx, and no bitter taste, stool is normal.Obeyed Chinese medicine composition of the present invention again 6 months, transference cure, 10 kilograms of weight increase, check: focus complete obiteration, not recurrence so far.
Five, therapeutic outcome:
In the 37 routine cases of being accepted for medical treatment,, wherein cure 8 examples through treatment in 9 months, produce effects 17 examples, effective 9 examples, invalid 3 examples, total effective rate reaches 91 %.The result shows that Chinese medicine composition of the present invention has extremely significant curative effect to treatment duodenal carcinoma patient.
Claims (4)
1. Chinese medicine composition for the treatment of duodenal carcinoma, it is characterized in that: the weight portion of each crude drug is:
20 parts of Indigo Naturaliss, 50 parts of Semen Coiciss, 100 parts in Poria, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 20 parts of Lignum Dalbergiae Odoriferaes, 20 parts of Styrax, 20 parts of Herba Lysimachiae foenum-graeci, 15 parts of Radix Et Rhizoma Rhei, 20 parts of Rhizoma Corydalis, 10 parts of Olibanum (processed), 10 parts of Myrrha (processed)s, 15 parts of RHZOMA SPARGANII, 15 parts of Rhizoma Curcumae, 20 parts in Radix Rubiae, 30 parts of Massa Medicata Fermentata, 15 parts of Semen Arecae Preparetas, 30 parts in Fructus Hordei Germinatus, 20 parts of Lignum Sappans, 10 parts of Sanguis Draxonis, 15 parts of Herba Taraxaci, 15 parts of Herba Violaes, 20 parts of Herba Patriniae, 30 parts of Radix Trichosanthis, 15 parts of Rhizoma Coptidis, 20 parts of Radix Arnebiae (Radix Lithospermi)s, 20 parts of Herba Houttuyniae, 20 parts of Radix Sophorae Tonkinensiss, 30 parts of Herba Lobeliae Chinensis, 30 parts of Fructus Aurantii Immaturuss, 10 parts of Lignum Aquilariae Resinatum, 30 parts of Rhizoma Chuanxiongs, 100 parts of Rhizoma Cyperis, 15 parts of Eupolyphaga Seu Steleophagas, 10 parts of Sanguis Draxonis, 30 parts of the Radix Paeoniae Albas, 20 parts of Radix Paeoniae Rubra, 20 parts of Cortex Magnoliae Officinalis, 10 parts of Fructus Amomis, 15 parts of Rhizoma Atractylodis, 15 parts of Rhizoma Zingiberiss, 15 parts of Rhizoma Polygoni Cuspidati, 20 parts of Radix Sophorae Flavescentiss, 15 parts of Radix Rehmanniae Preparata, 20 parts of Radix Scrophulariaes, process 15 parts of Squama Manis, 20 parts of Endothelium Corneum Gigeriae Galli, 30 parts of the Radixs Linderae, 20 parts of Bulbus Allii Macrostemonis, 15 parts of Aspongopuss, 20 parts of Semen Raphanis.
2. according to the described Chinese medicine composition of claim 1, it is characterized in that: the method for Chinese medicinal according to routine is prepared into any oral formulations commonly used.
3. according to the described Chinese medicine composition of claim 2, it is characterized in that: described oral formulations is pill, capsule, tablet, powder, granule or oral liquid.
4. the application of any described Chinese medicine composition of claim 1～3 in preparation treatment duodenum cancer drug.
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| CN103446559A (en) * | 2013-07-26 | 2013-12-18 | 杨德俊 | Traditional Chinese medicine composition for treating chronic gastritis |
| CN103611038B (en) * | 2013-12-02 | 2015-12-02 | 咸温东 | One treats pancreatitic Chinese medicine |
| CN103977356A (en) * | 2014-05-29 | 2014-08-13 | 李绍华 | Pharmaceutical composition for treating duodenal cancer and gastric cancer |
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| 李克华等.原发性十二指肠癌临床特征及治疗进展.《吉林医学》.2007,第28卷(第12期),1425-1426. * |
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