CN100998573A

CN100998573A - Effect and use of capusle prepared by blending multiple sola-red-agent

Info

Publication number: CN100998573A
Application number: CN 200610036078
Authority: CN
Inventors: 郭富凤
Original assignee: Jianyong Biological Science & Technology Co Ltd Ningbo City
Current assignee: Guo Fufeng
Priority date: 2006-06-26
Filing date: 2006-06-26
Publication date: 2007-07-18

Abstract

A capsule for resisting against oxidizing, delaying cell sanility, repairing human immune system and preventing and treating cancers is prepared from lycopene, phytoene, phytofluene, etc.

Description

The capsular effect and the purposes of multiple lycopene blending preparation

[technical field]

The present invention relates to the lycopene in the eggplant class melon and fruit, especially relate to the capsule of lycopene preparation, belong to health product and field of medicaments.

[background technology]

Lycopene (Lycopene) extensively is present in the multiple sophisticated melon and fruit class fruit, for example Fructus Lycopersici esculenti, Radix Dauci Sativae, Fructus Chaenomelis, Fructus Cucurbitae moschatae, Citrullus vulgaris etc.

People are to the development and utilization of lycopene (Lycopene), mainly be as a kind of food coloring at first, as a kind of coloration additive of food, found after deliberation afterwards, contain carotenoid in the lycopene, carotenoid is prevalent in human plasma and the hetero-organization thereof, and studies show that lycopene has anti-oxidation function, can eliminate various harmful oxygen radicals, reducing human cell aging, the health that can gain and prevention, some disease of treatment human body.

Utilize the known fat-soluble characteristics of lycopene (Lycopene), cooperate various edible oil to make various lycopene goods so that be the product of the better absorption of human body and utilization and some disease of prophylactic treatment human body, existing development and utilization, quite a fewly on market see, with this as patent application even get permission to become patented technology and also can from the disclosed patent document of State Intellectual Property Office, retrieve, for example:

The open date disclosure composite of numbering document number

1. CN1327749A 2001-12-26 lycopene+edible oil lycopene oil

2. CN1343518A 2002-4-10 lycopene+tomato seed oil lycopene capsule oil ball

3. CN1352940A 2002-6-12 lycopene+tomato seed oil Licopin linoleate capsule

4. CN1352939A 2002-6-12 lycopene+vitamin A lycopene capsule

More than disclosed patent document, all with single lycopene and utilize the known fat-soluble characteristics of lycopene to concoct various edible oils, for example number 1, name is called the patent of invention of " lycopene oil ", its disclosed content is that single lycopene adds various edible oil, as salad oil, Oleum Arachidis hypogaeae semen, Oleum Glycines, Oleum Brassicae campestris, Oleum Helianthi, Oleum sesami, Semen Tritici aestivi germ oil, Camellia oil, Semen Maydis oil, big Miyou, safflower oil, Testa oryzae oil, Oleum Gossypii semen, miscella, olive oil, Petiolus Trachycarpi oil, blending becomes lycopene oil; Numbering 2, denomination of invention are " effect and the purposes of concocting the soft capsule oil ball of preparation with tomato seed oil and red pigment ", and its disclosed content is the oily ball of soft capsule with tomato seed oil and lycopene preparation, also is to utilize single lycopene to add tomato seed oil; The patent of invention of numbering 3, numbering 4 is an identical content with the patent of invention of numbering 2, the weak point of above patent document disclosure is, only utilize some function and the fat-soluble characteristics of single lycopene, and do not had other collaborative compositions to strengthen and give full play to the function of lycopene.

Show through scientific research, the eggplant type objects is except that can extracting lycopene (Lycopeme), can also extract some other active substance for human body gain health and control various diseases, for example octahydro lycopene (Phytoene) and six hydrogen lycopene (Phytonuene), just these materials exist only in through the eggplant type objects of special cultivation and are present on a small quantity in the common eggplant type objects, in extraction process, there is big difficulty, extraction process is had relatively high expectations, so obtain development and utilization, and during the directly edible eggplant type objects of people, exist because of these materials are just a small amount of, can not in edible, absorb required dosage, can not get effective effect.

Since lycopene (Lycopene) derives from the eggplant class fruit cell wall and the tissue of protein and fiber in, so be difficult for being absorbed by human body, even the process of direct edible fresh eggplant class fruit, also be difficult for from wherein absorbing the effective lycopene dosage of human body, therefore, lycopene be applied to gain health and prevention, some disease of treatment human body remain at present needs further solve three aspect technical problem: the first, from the eggplant type objects, extract the active ingredient of multiple gain health; The second, utilize the synergism of the various active ingredients that extract to bring into play better gain effect; The 3rd, more effectively be absorbed by the body and utilize.

[innovation and creation content]

Purpose of the present invention, be to provide a kind of to gain health and prevention, some disease of treatment human body has the capsule of multiple efficacies and multi-purpose multiple lycopene blending preparation, described capsule is mainly by the lycopene in the carotenoid (Lycopene), octahydro lycopene (Phytoene), six hydrogen lycopene (Phytofluene) and other carotenoid and the blending of some other synergistic substance are prepared from, give full play to the synergism of various compositions, to solve aforementioned lycopene the still need technical problem of three aspects that further solve of health and some disease of control human body that is applied to gain.

Technical scheme of the present invention and core place, utilize the gain function of lycopene just to health, blending cooperates other compositions again with octahydro lycopene and six hydrogen lycopene, blending becomes multiple lycopene, utilize the synergism after various compositions are concocted, to produce more significant function and beyond thought effect.

The technical solution used in the present invention is, from through extracting the active ingredient of multiple main carotenoid the eggplant type objects of special cultivation and the common eggplant type objects, comprising: lycopene (Lycopene), octahydro lycopene (Phytoene) and six hydrogen lycopene (Phytofluene), be mixed into multiple lycopene with certain proportion, cooperate an amount of β-carotenoid again, γ-carotenoid, delta carotene (Carotene), phytosterol (Phytosterols), or natural Vitamin E (Tocopherols, Vitamin E), phospholipid (Phospholipids), blending or Fructus Lycopersici esculenti oils and fats (Tomato oil), Semen Cucurbitae oils and fats (Pumpkin seed Oil) or soybean oil (Soya Oil) or Fructus Lycopersici esculenti oils and fats (Tomato oil) are prepared into capsule in certain proportion, wherein, the Main Ingredients and Appearance lycopene accounts for 6%-15%; The octahydro lycopene accounts for 0.5%-5%; Six hydrogen lycopene account for 0.5%-5%; Other compositions account for 93%-75%.

Utilize the synergism between octahydro lycopene (Phytoene), six hydrogen lycopene (Phytofluene) and the lycopene (Lycopene) to produce more significant function and beyond thought effect, it is the core place of the invention achievement and technical scheme, at present, still find no and utilize octahydro lycopene, six hydrogen lycopene and the synergistic application precedent of lycopene.

Test shows, octahydro lycopene and six hydrogen lycopene provide 30% total carotinoid nearly, the synergism of itself and lycopene is better than single lycopene or single octahydro lycopene or single six hydrogen lycopene, can bring into play the remarkable efficacy and the beneficial effect of gain health, more effectively absorbed by human body, produce existing other technologies scheme inaccessiable remarkable efficacy of institute and beneficial effect, the result of test is as follows:

Test one:

1, test name: the lycopene blending octahydro lycopene of physiological concentration and six hydrogen lycopene are for the synergy that suppresses human body prostate gland cancer cell propagation.

2, test method: with the human body prostate gland cancer cell separately with lycopene (Lycopene) or separately and octahydro lycopene (Phytoene) or independent and six hydrogen lycopene (Phytofluene) preparations cultivate, the result is not having significantly reduction aspect the prostate gland cancer cell propagation, and cultivate with octahydro lycopene+six hydrogen lycopene+lycopene blending preparation, can obviously observe has significant reduction on the propagation of prostate gland cancer cell.

3, test effect comparison diagram: as shown in Figure 2

4 result of the tests:

(Fig. 2) can see from the test effect comparison diagram

(1) lycopene (Lycopene) 2 there is no effective inhibition for 1 time and reduces prostate gland cancer cell propagation at physiological concentration separately;

(2) octahydro lycopene (Phytoene)/six hydrogen red pigment (Phytofluene) 3 there is no effective inhibition separately and reduces prostate gland cancer cell propagation under physiological concentration;

(3) lycopene (Lycopene)+octahydro lycopene (Phytoene)+six hydrogen lycopene (Phytofluene) 4 can effectively suppress and reduce prostate gland cancer cell propagation under physiological concentration.

Test two

1, test name: the lycopene blending octahydro lycopene of physiological concentration and six hydrogen lycopene are for the synergy that suppresses human body breast cancer cell propagation.

2, test method: with the human body breast cancer cell separately with lycopene (Lycopene) or separately and octahydro lycopene (Phytoene) or independent and six hydrogen lycopene (Phytofluene) preparations cultivate, pro-breast cancer cell propagation aspect does not all have significantly to reduce as a result, and cultivate with octahydro lycopene+six hydrogen lycopene+lycopene blending preparation, can obviously observe has significant reduction on the propagation of breast cancer cell. always

3, comparison diagram: as shown in Figure 3

4, result of the test:

(Fig. 3) can see from the test effect comparison diagram

(1) lycopene (Lycopene) 7 there is no effective inhibition for 5 times and reduces breast cancer cell propagation at physiological concentration separately;

(2) octahydro lycopene (Phytoene)/six hydrogen red pigment (Phytofluene) 6 there is no effective inhibition separately and reduces breast cancer cell propagation under physiological concentration;

(3) lycopene (Lycopene)+octahydro lycopene (Phytoene)+six hydrogen lycopene (Phytofluene) 8 can effectively suppress and reduce breast cancer cell propagation under physiological concentration.

The capsule of the multiple lycopene blending of the present invention preparation can be convenient for people to take with human body and better absorb and utilization, give full play to the synergism of multiple lycopene, improve the anti-oxidation function of lycopene, wearing out of reducing human cell, repair the human immune system, have defying age, anti-cancer, anticancer effect, especially to control prostatic hyperplasia prostatosis, carcinoma of prostate, breast carcinoma and prevention of arterial sclerosis, effect is preferably arranged for cardiovascular and cerebrovascular diseases such as myocardial infarction and morbus cardiacuses.Because concoction is to adopt the extraction of pure natural plant eggplant class, does not have harmful composition and nonhazardous side effect.

[description of drawings]

Fig. 1 is the extraction process figure of natural eggplant class extract;

Fig. 2 is the lycopene blending octahydro lycopene and the six hydrogen lycopene of physiological concentration, for the synergy that suppresses human body prostate gland cancer cell propagation and lycopene or octahydro lycopene or independent six hydrogen lycopene test effect comparison diagrams separately separately;

Fig. 3 is the lycopene blending octahydro lycopene of physiological concentration and the synergy and lycopene or octahydro lycopene or independent six hydrogen lycopene test effect comparison diagrams separately separately that six hydrogen lycopene are bred for inhibition human body breast cancer cell.

Among the figure

1, the physiological concentration of lycopene in blood,

2, lycopene;

3, octahydro lycopene/six hydrogen lycopene;

4, lycopene (0.3 μ M/lifer) adds octahydro lycopene/six hydrogen lycopene;

5, the physiological concentration of lycopene in blood;

6, octahydro lycopene/six hydrogen lycopene;

7, lycopene;

8, lycopene (0.3 μ M/lifer) adds octahydro lycopene/six hydrogen lycopene;

[specific embodiment]

The specific embodiment of the present invention is as follows, and wherein percentage ratio is weight ratio:

Embodiment one:

Lycopene (Lycopene) 6%-15%

Octahydro lycopene (Phytoene) 0.5%-5%

Six hydrogen lycopene (Phytofluene) 0.5%-5%

β-carotenoid (β 3-Carotene) 1%

(γ-Carotene) 1% for γ-carotenoid

(δ-Carotene) 1% for delta carotene

Phytosterol (Phytosterols) 1%

Semen Cucurbitae oils and fats (Pumpkin seed Oil) 89%-71%

Embodiment two:

Lycopene (Lycopene) 6%-15%

Octahydro lycopene (Phytoene) 0.5%-5%

Six hydrogen lycopene (Phytofluene) 0.5%-5%

Natural Vitamin E (Tocopherols) 2%

Phospholipid (Phosphol ipids) 10%

Semen Cucurbitae oils and fats (Pumpkin seed Oil) 81%-65%

Embodiment three:

Lycopene (Lycopene) 6%-10%

Octahydro lycopene (Phytoene) 0.5%-5%

Six hydrogen lycopene (Phytofluene) 0.5%-5%

Semen Cucurbitae oils and fats (Pumpkin seed Oil) 93%-75%

Claims

1, the capsule of multiple lycopene blending preparation is characterized in that: described capsule includes lycopene (Lycopene), octahydro lycopene (Phytoene), six hydrogen lycopene (Phytofluene), β-carotenoid (β-Carotene), γ-carotenoid (γ-Carotene), delta carotene (δ-Carotene), phytosterol (Phytosterols), Semen Cucurbitae oils and fats (Pum pkin seedoi).

2, the capsule of multiple lycopene blending preparation according to claim 1 is characterized in that:

Lycopene (Lycopene) 6%-15%;

Octahydro lycopene (Phytoene) 0.5%-5%;

Six hydrogen lycopene (Phytofluene) 0.5%-5%;

(β-Carotene) 1% for β-carotenoid;

(γ-Carotene) 1% for γ-carotenoid;

(δ-Carotene) 1% for delta carotene;

Phytosterol (Phytosterol) 1%;

Semen Cucurbitae oils and fats (Pumpkin seed Oil) 89%-71%;

Wherein percentage ratio is weight ratio.

3, the capsule of multiple lycopene blending preparation according to claim 1 is characterized in that:

Lycopene (Lycopene) 6%-15%;

Octahydro lycopene (Phytoene) 0.5%-5%;

Six hydrogen lycopene (Phytofluene) 0.5%-5%;

Natural Vitamin E (Tocopherol) 2%;

Phospholipid (Phospholipidl) 10%;

Semen Cucurbitae oils and fats (Pumpkin seed Oil) 81%-63%;

Wherein percentage ratio is weight ratio.

4, the capsule of multiple lycopene blending preparation according to claim 1 is characterized in that:

Lycopene (Lycopene) 6%-10%;

Octahydro lycopene (Phytoene) 0.5%-5%;

Six hydrogen lycopene (Phytofluene) 0.5%-5%;

Semen Cucurbitae oils and fats (Pumpkin seed Oil) 93%-75%;

Wherein percentage ratio is weight ratio.

5, the capsule of multiple lycopene blending preparation according to claim 1 is characterized in that:

Described Semen Cucurbitae oils and fats (Pumpkin seed Oil) can be replaced by soybean oil (soya Oil) or Fructus Lycopersici esculenti oils and fats (Tomato Oil).