CN108669529A - 一种灵芝孢子提取物冻干粉微胶囊含片的制备方法 - Google Patents

一种灵芝孢子提取物冻干粉微胶囊含片的制备方法 Download PDF

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CN108669529A
CN108669529A CN201810506522.7A CN201810506522A CN108669529A CN 108669529 A CN108669529 A CN 108669529A CN 201810506522 A CN201810506522 A CN 201810506522A CN 108669529 A CN108669529 A CN 108669529A
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ganoderma spore
freeze
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丁文洲
丁浩
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Anhui Huoshan Yipintang Biotechnology Co Ltd
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Abstract

本发明公开了一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，本发明进行收集灵芝孢子干燥液氮降温粉碎破壁后，煎煮提取，浓缩至结晶，预冻冷冻真空干燥，粉碎过筛，与壳聚糖、魔芋胶、大豆蛋白混合，在植物油分散剂中分散均匀，辐射灭菌，与其他添加剂混合均匀后，调整物料黏合度和湿润度，造粒压成片剂，抛光后，制得含片，既得。本发明通过收集灵芝孢子、进行提取冻干、包裹造粒压成片剂，制得含片风味独特，具有缓释作用，使得有效成分可缓慢的被吸收，具有保健功效。

Description

一种灵芝孢子提取物冻干粉微胶囊含片的制备方法
技术领域
本发明涉及食用菌生产技术领域，具体涉及一种灵芝孢子提取物冻干粉微胶囊含片的制备方法。
背景技术
灵芝是我国传统的菌类珍品，享有“仙草”美誉。灵芝又称灵芝草、仙草，别称赤芝、红芝、木灵芝、菌灵芝、万年蕈、灵芝草，是多孔菌科植物赤芝或紫芝的全株，为多孔菌科真菌灵芝的子实体。外形呈伞状，菌盖肾形、半圆形或近圆形。《神农本草经》和《本草纲目》即详细记载了灵芝的药效及功能。灵芝已作为药物正式被国家药典收载，是国家批准的新资源食品，可药食两用。灵芝作为拥有数千年药用历史的中国传统珍贵药材，具有补气安神，止咳平喘的功效，用于眩晕不眠，心悸气短，虚劳咳喘。灵芝具备很高的药用价值，灵芝孢子粉是灵芝生长成熟期从菌盖弹射出来极其细小的孢子，为灵芝的生殖细胞。大量的实验证实孢子粉具有较强的抗肿瘤、免疫调节、调节血脂血糖的功效以及对神经系统、心血管和呼吸系统有调节改善作用而受到社会大众的追捧。
发明内容
本发明提供一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，本发明通过收集灵芝孢子、进行提取冻干、包裹造粒压成片剂，制得含片风味独特，具有缓释作用，使得有效成分可缓慢的被吸收，具有保健功效。
本发明是通过以下技术方案实现的：
一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，其特征在于，包括以下步骤：
（1）制备灵芝孢子提取物
在灵芝开盖生长，即将喷射孢子粉时，取灵芝孢子，干燥后，经粉碎机粉碎，在粉碎机中加入液氮，使体系温度为-190℃，进行粉碎破壁后，加入适量的水分，调节物料含水量60-80%，之后置提取罐中，加热煎煮1-2次，滤过，合并滤液，得灵芝孢子提取物；
（2）灵芝孢子提取物冻干粉
将步骤（1）所得的灵芝孢子提取物浓缩至结晶，静置，放入冻干机预冻，预冻温度-25--30℃，冻结时间为3-5小时，缓慢升温进行真空干燥，在室温，相对湿度控制在30%以下进行粉碎干燥，过60-80目筛，得灵芝孢子提取物冻干粉；
（3）分散于灭菌
将步骤（2）所得灵芝孢子提取物冻干粉与壳聚糖、魔芋胶、大豆蛋白按比例进行混合，加入到植物油分散剂中，利用胶体磨与超声处理使其充分混合均匀，采用电子束辐射灭菌，待用；
（4）压片
将步骤（3）所得物与其他添加剂按一定比例混合均匀后，调整物料黏合度和湿润度，获得软硬适中的软料，然后过18-20目筛造粒，鼓风干燥箱中干燥，将烘干后的颗粒中加入润滑剂，混合均匀，送入压片机中，压成片剂，抛光后，制得含片，既得所述的灵芝孢子提取物冻干粉微胶囊含片。
所述干燥方式为冷冻干燥、真空干燥或喷雾干燥。
所述的粉碎破壁是将混合料置于高速粉碎机中进行粉碎破壁，制成超细粉。
所述植物油分散剂为茶树油、玫瑰花油、橄榄油。
所述的灭菌电子束能量为3-4MeV，灭菌时间为2-4h。
所述的其他添加剂为糊精、蔗糖、聚乙烯吡咯烷酮。
本发明的优点是：
本发明进行收集灵芝孢子干燥液氮降温粉碎破壁后，煎煮提取，浓缩至结晶，预冻冷冻真空干燥，粉碎过筛，与壳聚糖、魔芋胶、大豆蛋白混合，在植物油分散剂中分散均匀，辐射灭菌，与其他添加剂混合均匀后，调整物料黏合度和湿润度，造粒压成片剂，抛光后，制得含片，既得。本发明及时进行收集孢子，损失小，纯度高，效率高，低温粉碎后使得灵芝孢子内部的纤维断裂，活性物质在不被破坏的情况下溢出，煎煮使得有效成分溶解在水中之后浓缩进行冷冻干燥，避免在加工过程中的色变、风味丧失、营养损失及风味不佳等问题，最大程度的发挥保健的有益功效，冻干粉碎提高了活性物质的释放速率和释放量，提高了有效成分的提取得率，之后与壳聚糖、魔芋胶、大豆蛋白混合，壳聚糖等将冻干粉进行包裹起来，可以有效保持化学稳定性，达到控释的效果，放入口腔中后，会缓慢溶化，采用了电子束辐射灭菌的方法，灭菌彻底，无污染与残毒，加入辅料后可掩盖灵芝提取物的的不良气味与口感，控制了产品的溶出率，更好的保证了产品的质量。本发明通过收集灵芝孢子、进行提取冻干、包裹造粒压成片剂，制得含片风味独特，具有缓释作用，使得有效成分可缓慢的被吸收，具有保健功效。
具体实施方式
一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，其特征在于，包括以下步骤：
（1）制备灵芝孢子提取物
在灵芝开盖生长，即将喷射孢子粉时，取灵芝孢子，干燥后，经粉碎机粉碎，在粉碎机中加入液氮，使体系温度为-190℃，进行粉碎破壁后，加入适量的水分，调节物料含水量60-80%，之后置提取罐中，加热煎煮1-2次，滤过，合并滤液，得灵芝孢子提取物；
（2）灵芝孢子提取物冻干粉
将步骤（1）所得的灵芝孢子提取物浓缩至结晶，静置，放入冻干机预冻，预冻温度-25--30℃，冻结时间为3-5小时，缓慢升温进行真空干燥，在室温，相对湿度控制在30%以下进行粉碎干燥，过60-80目筛，得灵芝孢子提取物冻干粉；
（3）分散于灭菌
将步骤（2）所得灵芝孢子提取物冻干粉与壳聚糖、魔芋胶、大豆蛋白按比例进行混合，加入到植物油分散剂中，利用胶体磨与超声处理使其充分混合均匀，采用电子束辐射灭菌，待用；
（4）压片
将步骤（3）所得物与其他添加剂按一定比例混合均匀后，调整物料黏合度和湿润度，获得软硬适中的软料，然后过18-20目筛造粒，鼓风干燥箱中干燥，将烘干后的颗粒中加入润滑剂，混合均匀，送入压片机中，压成片剂，抛光后，制得含片，既得所述的灵芝孢子提取物冻干粉微胶囊含片。
所述干燥方式为冷冻干燥、真空干燥或喷雾干燥。
所述的粉碎破壁是将混合料置于高速粉碎机中进行粉碎破壁，制成超细粉。
所述植物油分散剂为茶树油、玫瑰花油、橄榄油。
所述的灭菌电子束能量为3-4MeV，灭菌时间为2-4h。
所述的其他添加剂为糊精、蔗糖、聚乙烯吡咯烷酮。

Claims (6)

1.一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，其特征在于，包括以下步骤：
制备灵芝孢子提取物
在灵芝开盖生长，即将喷射孢子粉时，取灵芝孢子，干燥后，经粉碎机粉碎，在粉碎机中加入液氮，使体系温度为-190℃，进行粉碎破壁后，加入适量的水分，调节物料含水量60-80%，之后置提取罐中，加热煎煮1-2次，滤过，合并滤液，得灵芝孢子提取物；
（2）灵芝孢子提取物冻干粉
将步骤（1）所得的灵芝孢子提取物浓缩至结晶，静置，放入冻干机预冻，预冻温度-25--30℃，冻结时间为3-5小时，缓慢升温进行真空干燥，在室温，相对湿度控制在30%以下进行粉碎干燥，过60-80目筛，得灵芝孢子提取物冻干粉；
（3）分散于灭菌
将步骤（2）所得灵芝孢子提取物冻干粉与壳聚糖、魔芋胶、大豆蛋白按比例进行混合，加入到植物油分散剂中，利用胶体磨与超声处理使其充分混合均匀，采用电子束辐射灭菌，待用；
压片
将步骤（3）所得物与其他添加剂按一定比例混合均匀后，调整物料黏合度和湿润度，获得软硬适中的软料，然后过18-20目筛造粒，鼓风干燥箱中干燥，将烘干后的颗粒中加入润滑剂，混合均匀，送入压片机中，压成片剂，抛光后，制得含片，既得所述的灵芝孢子提取物冻干粉微胶囊含片。
2.根据权利要求1一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，其特征在于，所述干燥方式为冷冻干燥、真空干燥或喷雾干燥。
3.根据权利要求1一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，其特征在于，所述的粉碎破壁是将混合料置于高速粉碎机中进行粉碎破壁，制成超细粉。
4.根据权利要求1一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，其特征在于，所述植物油分散剂为茶树油、玫瑰花油、橄榄油。
5.根据权利要求1一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，其特征在于，所述的灭菌电子束能量为3-4MeV，灭菌时间为2-4h。
6.根据权利要求1一种灵芝孢子提取物冻干粉微胶囊含片的制备方法，其特征在于，所述的其他添加剂为糊精、蔗糖、聚乙烯吡咯烷酮。
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115429849A (zh) * 2022-08-23 2022-12-06 江西大自然制药有限公司 一种固本延龄丸的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
蔡津生，等: "《中国食药用菌工程学》", 31 January 2015, 上海科学技术文献出版社 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115429849A (zh) * 2022-08-23 2022-12-06 江西大自然制药有限公司 一种固本延龄丸的制备方法

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