CN108617664A - Bactericidal composition containing propamidine and amisulbrom - Google Patents
Bactericidal composition containing propamidine and amisulbrom Download PDFInfo
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- CN108617664A CN108617664A CN201810335031.0A CN201810335031A CN108617664A CN 108617664 A CN108617664 A CN 108617664A CN 201810335031 A CN201810335031 A CN 201810335031A CN 108617664 A CN108617664 A CN 108617664A
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- Prior art keywords
- propamidine
- amisulbrom
- bactericidal composition
- composition according
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of containing the bactericidal composition that active ingredient is propamidine and amisulbrom, including usual auxiliaries, propamidine and amisulbrom, and the quality parts ratio of propamidine and amisulbrom is 3:1~1:12, preferably than being 1:1~1:9, more preferably than being 1:3~1:5.Propamidine and there is synergistic effect to pathogen fungi and crop root increase after being compounded in certain proportion with amisulbrom, is suitable for prevention by the fungus-caused crop disease of pathogen and enhancing crop root.
Description
Technical field
The invention belongs to synergetic pesticide composition fields, and in particular to one kind containing active constituent propamidine and indazole sulphur bacterium
The composition pesticide of amine.
Technical background
Propamidine, chemical name 1,3- bis- (4- amidinophenoxies) propane belong to aromatic diamidine compound.Propamidine is interior
Absorption fungicide can have protection and therapeutic effect in plant body absorption, distribution and metabolism, be mainly used for prevention by grape
Crop gray mold caused by spore category pathogen simultaneous can also control the crop diseases such as crop downy mildew, late blight.
Amisulbrom (amisulbrom) is triazolylsulfonamide series bactericidal agent, effective to oomycetes and mycetozoan, especially right
Zoospore activity is very high, is mainly used for crop disease caused by preventing Oomycete fungal, such as downy mildew of garpe, potato late blight
Disease etc., resistance of rainwater washing against, lasting effect are strong.
It is one of prevention most effective chemical means of phytopathogen using chemical agent；With the novel pesticide of not cross resistance
It is a good solution to carry out controlling plant diseases；But one novel pesticide of exploitation needs to screen a chemical combination up to ten thousand at present
Object, hundred million dollars of cost 1.2-1.5, the development cycle is 5-10, it is difficult to the speed that the upper pathogen caught up with develops immunity to drugs；It is other
Method such as crop structure adjustment, different pesticide rotations etc., in actual mechanical process, it is difficult to play apparent effect.
Develop new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research
Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.
The synergistic combination of propamidine and amisulbrom has not been reported, the mechanism of action and work of propamidine and amisulbrom
With feature difference.
Invention content
The present invention is intended to provide a kind of Synergistic bactericidal composition containing propamidine and amisulbrom, is convenient for crop disease
Resistance management, health control and reduction Pesticide use amount.
The invention is realized by the following technical scheme：
The bactericidal composition containing propamidine and amisulbrom, active constituent are propamidine and indazole sulphur bacterium
The mass fraction ratio of amine, preferred propamidine and amisulbrom is 3:1~1:12.
The mass fraction ratio of further preferred propamidine and amisulbrom is 1:1~1:9.
The mass fraction ratio of further preferred propamidine and amisulbrom is 1:3~1:5.
The mass fraction ratio of further preferred propamidine and amisulbrom is 1:3.
The mass fraction ratio of further preferred propamidine and amisulbrom is 1:4.
The mass fraction ratio of further preferred propamidine and amisulbrom is 1:5.
The bactericidal composition containing propamidine and amisulbrom removes and contains active constituent propamidine and indazole sulphur bacterium
Outside amine, also contain auxiliary agent；The weight of active component is the 1%~40% of composition total weight, remaining is insecticides adjuvant.
The composition pesticide, being processed into microemulsion, water dispersible granules, granule etc., agriculturally common dosage form is just
In agriculturally using, aqueous suspension agent, aqueous emulsion, dispersible oil-suspending agent, missible oil, suspension emulsion, wettable powder can also be processed into
Other formulations of pesticide such as agent.
The granule dosage form weight percent group becomes：Propamidine 0.1~2%, amisulbrom 0.1~6% divide
Powder 0.1~6%, wetting agent 0.1~6%, binder 0.1~6%, carrier complement to 100%.Specifically production stage is：Tool
Body production stage is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, is then added
It is granulated, dried, sieved in fluidized bed granulating and drying machine, the granule of corresponding weight percentage is made.
The dosage form of water dispersible granule weight percent group becomes：Propamidine 0.1~10%, amisulbrom 0.1~
30%, dispersant 0.1~20%, disintegrant 0.1~8%, wetting agent 0.1~8%, solid carrier complements to 100%.It is specific raw
Producing step is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, stream is then added
Change and be granulated in bed granulating and drying machine, dry, sieve, the water dispersible granules of corresponding weight percentage are made.
The micro-emulsion form weight percent group becomes：Propamidine 0.1~15%, amisulbrom 0.1~15%,
Dispersant 0.1~15%, emulsifier 0.1-15%, solvent 0.1~30%, antifreezing agent 0.1~5%, deionized water complements to
100%.Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, after active ingredient and auxiliary agent dissolving, are placed in appearance
It is sheared 5 minutes~2 hours with cutter in device, obtains the microemulsion of corresponding weight percentage.
The antifreezing agent can be one or more of in glycerine, propylene glycol, diethylene glycol (DEG), urea etc..
The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur
One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..
The emulsifier can be triphenoethyl benzene phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane, castor oil
One kind in polyoxyethylene ether, fatty alcohol polyoxy ether, aliphatic acid polyethenoxy ether, isomery alcohol.
The dispersant can be APES formaldehyde condensation product, naphthalene sulfonate, benzene sulfonate, to methoxy
Base fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fat
One kind in alcohol polyoxyethylene ether, polyethylene glycol stearate, Oleate, nekal, phosphate etc.
Or it is several.
The disintegrant can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium,
Crospovidone, chitosan, sodium alginate, sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc.
One or more of.
The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon, clay,
One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..
The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine
Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin,
One or more of rosin, wood powder etc..
The solvent can be solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropanol, n-butanol, n-octyl alcohol, positive penta
Alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N-Methyl pyrrolidone, ethyl acetate, methyl oleate, phthalic acid
Dibutyl ester, sec-Butyl Acetate.
The deionized water is industrial deionized water.
It is found by experiment that, propamidine is used in mixed way with amisulbrom to pythium (Pythium), Phytophthora
(Phytophthora), Peronospora (Peronospora), Pseudoperonospora (Pseudoperonospora), white Phytophthora
(Peronophythora), refer to Phytophthora (Sclerophthora), white rust category (Albugo), Sclerospora
(Sclerospora), Plasmopara (Plasmopara), Bremia (Bremia) etc. have synergistic effect.
The present invention has the advantages that：
1, the composition pesticide provided by the invention containing active constituent propamidine and amisulbrom, propamidine and indazole
Flusulfamide has synergistic effect, such as phytophthora infestans within the scope of certain proportion to the toxicity of target pathogen
(Phytophthora infestans)。
2, composition pesticide of the present invention has synergistic effect to target pathogen, it is possible to reduce Pesticide use amount reduces agriculture
The pollution of control of crop disease cost, mitigation to environment.
3, present composition active constituent propamidine and amisulbrom are total to maize root system within the scope of certain proportion
Amount, which increases, has synergistic effect.
Specific implementation mode
(1), raw to survey embodiment
According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association
Same antagonism, 80 ＜ CTC ＜ 120 are joint action of antagonism, and CTC >=120 are synergistic function.Survey toxicity index
(ATI)=(EC of standard agent50The EC of/reagent agent50)×100；The toxicity index of theoretical toxicity index TTI=A medicaments ×
In mixture in toxicity index × mixture of the percentage composition+B medicaments of A medicaments B medicaments percentage composition；Co-toxicity coefficient (CTC)=
[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100
Propamidine amisulbrom is to the Toxicity Determination of phytophthora infestans (Phytophthora infestans), examination
Test the pathogen phytophthora infestans (Phytophthora infestans) that object picks up from the late blight of potato in field.
Table 1：Propamidine amisulbrom surveys the indoor virulence of phytophthora infestans (Phytophthora infestans)
Determine result (mycelia growth method).
As shown in Table 1, propamidine and amisulbrom mixture are 3:1~1:Between 12, to phytophthora infestans
(Phytophthora infestans) has synergistic effect, and co-toxicity coefficient is 120 or more；Propamidine is mixed with amisulbrom
Fit over 1:1~1:There is synergistic effect, co-toxicity coefficient to exist phytophthora infestans (Phytophthora infestans) between 9
170 or more；Propamidine is with amisulbrom mixture 1:3~1:To phytophthora infestans (Phytophthora between 5
Infestans) there is apparent synergistic effect, co-toxicity coefficient is 180 or more；And propamidine exists with amisulbrom mixture
50:1~5:1 and 1:20~70 pairs of phytophthora infestans (Phytophthora infestans) co-toxicity coefficients are not 120 hereinafter, have
Synergistic effect.
Propamidine influences to test with amisulbrom on maize root system
Colby equatioies are used to determine desired effect (Colby, the S.R.Weeds1967,15,20- of mixture
22.Calculation of the synergistic and antagonistic response of herbicide
combinations)：
Following equatioies are used to calculate the desired value of the mixture containing two kinds of active components A and B：
In formula：
The effect of active components A of identical (dosage) concentration used in the mixture that A=is observed；
The effect of active constituent B of identical (dosage) concentration used in the mixture that B=is observed.
The active actual observation value (E) of the concentration (dosage) used in the mixture is more than desired value (E0) when, mixture is shown as
There is unexpected synergistic effect to target.
2 propamidine of table is mixed with amisulbrom to the test to corn (Zheng Dan 958) root system total amount (dry weight) increment rate
(cauline leaf is sprayed, and every plant of spray amount is 2 milliliters, dispenser when 11 heart of leaf of corn, is tested within 30 days after medicine)
The data result that table 2 is recorded shows that propamidine administration dosage (cauline leaf spraying) is 2 milliliters of 20 mg/kg and Yin
Azoles flusulfamide administration dosage (cauline leaf spraying) is that root system of 2 milliliters of 60 mg/kg to corn (Zheng Dan 958) increases with collaboration
Effect, the weight of root system increment rate that mixture observes are more than desired weight of root system increment rate 8.16%.
(2), example of formulations
0.1% propamidine, 0.3% amisulbrom granule
It is high to weigh 0.1% propamidine, 0.3% amisulbrom, 1% chitosan, 1% cornstarch, 4% wheat bran, surplus
Ridge soil.Above-mentioned raw materials are uniformly mixed in mixed cylinder, and by extruding, granulation, drying, and 0.1% propane is made in screened step
0.3% amisulbrom granule of amidine.
3% propamidine, 18% amisulbrom water dispersible granules
Weigh 3% propamidine, 18% amisulbrom, 10% benzene sulfonic acid sodium salt, 5% lauryl sodium sulfate, 5% tea seed cake
Powder, 5% sodium bicarbonate, surplus diatomite.Above-mentioned raw materials are uniformly mixed in mixed cylinder, by extruding, granulation, drying, and are passed through
3% propamidine, 18% amisulbrom water dispersible granules are made in screening step.
1% propamidine, 4% amisulbrom microemulsion
1% propamidine, 4% amisulbrom, 4% castor oil polyoxyethylene ether, 8% n-octyl alcohol, 3% chitosan are taken, on
State ingredient after mixing, deionized water complements to 100%, is placed in container and shears 30 points with 6000 turns of cutter per minute
Clock obtains 1% propamidine, 4% amisulbrom microemulsion.
(3), Application Example
3 1% propamidine of table, 3% amisulbrom microemulsion prevents the late blight of potato test of pesticide effectiveness
Claims (10)
1. the bactericidal composition containing propamidine and amisulbrom, it is characterised in that：Effective ingredient is propamidine and indazole sulphur
The mass fraction ratio of bacterium amine, propamidine and amisulbrom is 3:1~1:12.
2. bactericidal composition according to claim 1, it is characterised in that：The quality parts ratio of propamidine and amisulbrom
Example be：1:1~1:9.
3. bactericidal composition according to claim 1, it is characterised in that：The quality parts ratio of propamidine and amisulbrom
Example be：1:3~1:5.
4. bactericidal composition according to claim 1, it is characterised in that：The quality parts ratio of propamidine and amisulbrom
Example be：1:3.
5. bactericidal composition according to claim 1, it is characterised in that：The quality parts ratio of propamidine and amisulbrom
Example be：1:4.
6. bactericidal composition according to claim 1, it is characterised in that：The quality parts ratio of propamidine and amisulbrom
Example be：1:5.
7. bactericidal composition according to claim 1, the weight of active component is the 1%~40% of composition total weight,
Remaining is insecticides adjuvant.
8. bactericidal composition according to claim 5, it is characterised in that：The dosage form of the composition is granule, moisture
One kind in shot agent, microemulsion.
9. the bactericidal composition described in claim 4, microemulsion preparation method is as follows：Take 1% propamidine, 4% amisulbrom,
4% castor oil polyoxyethylene ether, 8% n-octyl alcohol, 3% chitosan, after mixing, deionized water complements to 100% to mentioned component, sets
It is sheared 30 minutes with 6000 turns of cutter per minute in container, obtains 1% propamidine, 4% amisulbrom microemulsion.
10. the bactericidal composition described in claim 1 to 6 any one is for preventing the late blight of potato, increasing maize root system
The purposes of total amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810335031.0A CN108617664A (en) | 2018-04-15 | 2018-04-15 | Bactericidal composition containing propamidine and amisulbrom |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810335031.0A CN108617664A (en) | 2018-04-15 | 2018-04-15 | Bactericidal composition containing propamidine and amisulbrom |
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| Publication Number | Publication Date |
|---|---|
| CN108617664A true CN108617664A (en) | 2018-10-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810335031.0A Pending CN108617664A (en) | 2018-04-15 | 2018-04-15 | Bactericidal composition containing propamidine and amisulbrom |
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| Country | Link |
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| CN (1) | CN108617664A (en) |
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2018
- 2018-04-15 CN CN201810335031.0A patent/CN108617664A/en active Pending
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| PB01 | Publication | ||
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Application publication date: 20181009 |