CN108293998A - bactericidal composition containing bromothalonil and carvacrol - Google Patents
bactericidal composition containing bromothalonil and carvacrol Download PDFInfo
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- CN108293998A CN108293998A CN201810221766.0A CN201810221766A CN108293998A CN 108293998 A CN108293998 A CN 108293998A CN 201810221766 A CN201810221766 A CN 201810221766A CN 108293998 A CN108293998 A CN 108293998A
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- carvacrol
- bromothalonil
- bactericidal composition
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- mass fraction
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of containing the bactericidal composition that active ingredient is bromothalonil and carvacrol, including usual auxiliaries, bromothalonil and carvacrol, and the quality parts ratio of bromothalonil and carvacrol is 50:1~1:10, preferably than being 30:1~1:1, more preferably than being 19:1~9:1.Bromothalonil and there is synergistic effect to pathogen fungi and crop root increase after being compounded in certain proportion with carvacrol, is suitable for prevention by the fungus-caused crop disease of pathogen and enhancing crop root.
Description
Technical field
The invention belongs to synergetic pesticide composition fields, and in particular to a kind of containing active constituent bromothalonil and carvacrol
Composition pesticide.
Technical background
Bromothalonil, english common name bromothalonil, chemical formula C6H6Br2N2, chemical name 1,2'- bis- bromo- 2,
4- dicyanobutanes.Bromothalonil is a kind of wide spectrum, low toxicity, mould proof, algae-killing bactericidal agent.It can inhibit and root out bacterium, fungi and algae
The growth of class has preferable control effect to corps diseases, especially has special efficacy to anthracnose.
Carvacrol, english common name carvacrol, chemical name：Carvacrol.Carvacrol is plant
Extract has preferable preventive effect to the crop gray mold caused by Botrytis pathogen, environmentally friendly.
It is one of prevention most effective chemical means of phytopathogen using chemical agent；With the novel pesticide of not cross resistance
It is a good solution to carry out controlling plant diseases；But one novel pesticide of exploitation needs to screen a chemical combination up to ten thousand at present
Object, hundred million dollars of cost 1.2-1.5, the development cycle is 5-10, it is difficult to the speed that the upper pathogen caught up with develops immunity to drugs；It is other
Method such as crop structure adjustment, different pesticide rotations etc., in actual mechanical process, it is difficult to play apparent effect.
Develop new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research
Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.
The synergistic combination of bromothalonil and carvacrol has not been reported, and the mechanism of action and action character of bromothalonil and carvacrol are not
Together.
Invention content
The present invention is intended to provide a kind of Synergistic bactericidal composition containing bromothalonil and carvacrol, is convenient for crop disease resistance
Management, health control and reduction Pesticide use amount.
The invention is realized by the following technical scheme：
The bactericidal composition containing bromothalonil and carvacrol, active constituent be bromothalonil and carvacrol, preferably
The mass fraction ratio of bromothalonil and carvacrol is 50:1~1:10.
The mass fraction ratio of further preferred bromothalonil and carvacrol is 30:1~1:1.
The mass fraction ratio of further preferred bromothalonil and carvacrol is 19:1~9:1.
The mass fraction ratio of further preferred bromothalonil and carvacrol is 19:1.
The mass fraction ratio of further preferred bromothalonil and carvacrol is 12:1.
The mass fraction ratio of further preferred bromothalonil and carvacrol is 9:1.
The bactericidal composition containing bromothalonil and carvacrol, in addition to containing active constituent bromothalonil and carvacrol, also
Contain auxiliary agent；The weight of active component is the 0.1%~60% of composition total weight, remaining is insecticides adjuvant.
The composition pesticide, being processed into microemulsion, water dispersible granules, granule etc., agriculturally common dosage form is just
In agriculturally using, aqueous suspension agent, aqueous emulsion, dispersible oil-suspending agent, missible oil, suspension emulsion, wettable powder can also be processed into
Other formulations of pesticide such as agent.
The granule dosage form weight percent group becomes：Bromothalonil 0.1~20%, carvacrol 0.01~10% divide
Powder 0.1~15%, wetting agent 0.1~10%, binder 0.1~14%, carrier complement to 100%.Specifically production stage is：
Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, then
It is added in fluidized-bed granulation dryer and is granulated, dries, sieve, the granule of corresponding weight percentage is made.
The dosage form of water dispersible granule weight percent group becomes：Bromothalonil 0.1~50%, carvacrol 0.01~
10%, dispersant 0.1~13%, disintegrant 0.1~13%, wetting agent 0.1~5%, solid carrier complements to 100%.Specifically
Production stage is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, is then added
It is granulated, dried, sieved in fluidized-bed granulation dryer, the water dispersible granules of corresponding weight percentage are made.
The micro-emulsion form weight percent group becomes：Bromothalonil 0.1~30%, carvacrol 0.01~10% divide
Powder 0.1~13%, emulsifier 2-10%, solvent 0.1~30%, antifreezing agent 0.1~5%, deionized water complements to 100%.
Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, after active ingredient and auxiliary agent dissolving, is placed in container and uses
Cutter is sheared -2 hours 5 minutes, and the microemulsion of corresponding weight percentage is obtained.
The antifreezing agent can be one or more of in glycerine, propylene glycol, diethylene glycol (DEG), urea etc..
The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur
One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..
The emulsifier can be agriculture breast 33#, agriculture breast 34#, agriculture breast 500#, agriculture breast 600#, Nongru-700 #, agriculture breast 1601#,
Agriculture breast 1602#, T60, S80, TX-10, OP-10, NP-10, Nonyl pheno (EO=10) ether phosphate, triphenoethyl benzene
One kind in phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane.
The dispersant can be APES formaldehyde condensation product, naphthalenesulfonate formaldehyde condensation compound, to first
Oxygroup fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, alkyl phenol polyoxyethylene ether sulfate, alkyl benzene sulphonate
Calcium salt, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyethylene glycol stearate, sorbose
One or more of alcohol oleate, nekal etc..
The disintegrant can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium,
Crospovidone, chitosan, sodium alginate sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc.
One or more of.
The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon, clay,
One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..
The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine
Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin,
One or more of rosin, wood powder etc..
The solvent can be toluene, dimethylbenzene, trimethylbenzene, solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropanol,
N-butanol, n-octyl alcohol, n-amyl alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N-Methyl pyrrolidone, acetonitrile, dichloromethane
Alkane, ethyl acetate, methyl oleate, dibutyl phthalate, sec-Butyl Acetate.
The deionized water is industrial deionized water.
It is found by experiment that, bromothalonil is used in mixed way with carvacrol to pythium (Pythium), Phytophthora
(Phytophthora), Peronospora (Peronospora), Pseudoperonospora (Pseudoperonospora), Sphaerotheca
(Sphaerotheca), Blumeria (Blumiria), Erysiphe (Erysiphe), Gibberella (Gibberella),
Sclerotinia (Sclerotinia), grape Sclerotinia (Botryotinia), Puccinia (Puccinia), Tilletia
(Tilletia), glue Rust (Gymnosporzngium), Phakopsora (Phakopsora), Ustilago (Ustilago),
Pyrenomycetes category (Rhizoctonia), Verticillium (Verticillium), Alternaria (Alternaria), Pyricularia Sacc.
(Pyriculara), Botrytis (Botrytis), Cercospora (Cercospora), Fusarium (Fusarium), colletotrichum
(Colletotrichum) etc. there is synergistic effect.
The present invention has the advantages that：
1, the composition pesticide provided by the invention containing active constituent bromothalonil and carvacrol, bromothalonil exist with carvacrol
There is synergistic effect to the toxicity of target pathogen within the scope of certain proportion, such as strawberry anthrax-bacilus (Colletotrichum
Fragariae Brooks), Botrytis cinerea (Botrytis cinerea).
2, composition pesticide of the present invention has synergistic effect to target pathogen, it is possible to reduce Pesticide use amount reduces agriculture
The pollution of control of crop disease cost, mitigation to environment.
3, present composition active constituent bromothalonil and carvacrol increase strawberry root system total amount within the scope of certain proportion
Add with synergistic effect.
Specific implementation mode
According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association
Same antagonism, 80 ＜ CTC ＜ 120 are joint action of antagonism, and CTC >=120 are synergistic function.Survey toxicity index
(ATI)=(EC of standard agent50The EC of/reagent agent50)×100；The toxicity index of theoretical toxicity index TTI=A medicaments ×
In mixture in toxicity index × mixture of the percentage composition+B medicaments of A medicaments B medicaments percentage composition；Co-toxicity coefficient (CTC)=
[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100
Embodiment one：Bromothalonil carvacrol is to strawberry anthrax-bacilus (Colletotrichum fragariae Brooks)
Toxicity Determination, subjects pick up from the pathogen strawberry anthrax-bacilus (Colletotrichum of the Strawberry anthracnose in field
fragariae Brooks)。
Table 1：Interior of the bromothalonil carvacrol to strawberry anthrax-bacilus (Colletotrichum fragariae Brooks)
Toxicity test result (mycelia growth method).
As shown in Table 1, bromothalonil and carvacrol mixture are 50:1~1:Between 10, to strawberry anthrax-bacilus
(Colletotrichum fragariae Brooks) has synergistic effect, and co-toxicity coefficient is 130 or more；Bromothalonil and perfume
Celery phenol mixture is 30:1~1:There is synergy to strawberry anthrax-bacilus (Colletotrichum fragariae Brooks) between 1
Effect, co-toxicity coefficient is 150 or more；Bromothalonil is with carvacrol mixture 19:1~9:To strawberry anthrax-bacilus between 1
(Colletotrichum fragariae Brooks) has apparent synergistic effect, and co-toxicity coefficient is 230 or more；And bromine
Bacterium nitrile is with carvacrol mixture 70:1 and 1:20~60 pairs of strawberry anthrax-bacilus (Colletotrichum fragariae Brooks)
Co-toxicity coefficient is 120 hereinafter, without synergistic effect.
Embodiment two：Bromothalonil carvacrol is to the Toxicity Determination of Botrytis cinerea (Botrytis cinerea), examination
Test the grey mould fruit rot of strawberry pathogen Botrytis cinerea (Botrytis cinerea) (mycelia growth method) that object picks up from field.
Table 2：The Toxicity Determination result of the bromothalonil carvacrol to Botrytis cinerea (Botrytis cinerea).
As shown in Table 2, bromothalonil and carvacrol mixture are 50:1~1:Between 10, to Botrytis cinerea (Botrytis
Cinerea) there is apparent synergistic effect, co-toxicity coefficient is 130 or more；Bromothalonil is with carvacrol mixture 30:1~1:1
Between, there is apparent synergistic effect to Botrytis cinerea (Botrytis cinerea), co-toxicity coefficient is 170 or more；Bromine bacterium
Nitrile is with carvacrol mixture 19:1~9:Between 1, there is apparent synergistic effect to Botrytis cinerea (Botrytis cinerea),
Co-toxicity coefficient is 210 or more；And bromothalonil and carvacrol mixture are 70:1 and 1:20~60 couples of Botrytis cinerea (Botrytis
Cinerea) has no synergistic effect, co-toxicity coefficient is below 120.
Three bromothalonil of embodiment influences to test with carvacrol on strawberry root system
Colby equatioies are used to determine desired effect (Colby, the S.R.Weeds1967,15,20- of mixture
22.Calculation of the synergistic and antagonistic response of herbicide
combinations)：
Following equatioies are used to calculate the desired value of the mixture containing two kinds of active components A and B：
In formula：
The effect of active components A of identical (dosage) concentration used in the mixture that A=is observed；
The effect of active constituent B of identical (dosage) concentration used in the mixture that B=is observed.
The active actual observation value (E) of the concentration (dosage) used in the mixture is more than desired value (E0) when, mixture is shown as
There is unexpected synergistic effect to target.
Test (the stem of 3 bromothalonil of table and the carvacrol mixing Herba Hyperici elodeoidis certain kind of berries (milk strawberry) root system total amount (dry weight) increment rate
Foliar spray mist, every plant of spray amount is 2 milliliters, is tested within 30 days after medicine)
The data result that table 3 is recorded shows that bromothalonil administration dosage (cauline leaf spraying) is 2 milliliters of 150 mg/kg and perfume
Celery phenol administration dosage (cauline leaf spraying) is that root system of 2 milliliters of 120 mg/kg to strawberry (milk strawberry) increases with collaboration work
With the weight of root system increment rate that mixture observes is more than desired weight of root system increment rate 14%.
1.9% bromothalonil of example IV, 0.1% carvacrol granule
Weigh 1.9% bromothalonil, 0.1% carvacrol, 2% sucrose, 1% buckwheat, 8% rice chaff, surplus attapulgite.On
It states raw material to be uniformly mixed in mixed cylinder, by extruding, granulation, drying, and 1.9% bromothalonil is made in screened step
0.1% carvacrol granule.
5 38% bromothalonil of embodiment, 2% carvacrol water dispersible granules
Weigh 38% bromothalonil, 2% carvacrol, 12% sodium butylnaphthalenesulfonate, 3% sodium lignin sulfonate, 5% tea seed cake powder,
4% sodium chloride, surplus white carbon.Above-mentioned raw materials are uniformly mixed in mixed cylinder, by extruding, granulation, drying, and screened step
Suddenly 2% carvacrol water dispersible granules of obtained 38% bromothalonil.
6 12% bromothalonil of embodiment, 1% carvacrol micro-emulsion
Take 12 parts of bromothalonils, 1 part of carvacrol, 7 parts of n-butanols, 5 parts of glycerine, 15 parts of sec-Butyl Acetates, triphenoethyl benzene
5 parts of phenol polyethenoxy ether phosphate, mentioned component after mixing, are added 55 parts of deionized waters and are placed in container with per minute
6000 turns of cutter is sheared 30 minutes, that is, makes 12% bromothalonil, 1% carvacrol micro-emulsion.
Seven Application Example of embodiment
4 12% bromothalonil of table, 1% carvacrol micro-emulsion prevents the grey mould fruit rot of strawberry test of pesticide effectiveness (greenhouse, cauline leaf spraying)
Claims (10)
1. the bactericidal composition containing bromothalonil and carvacrol, it is characterised in that：Effective ingredient is bromothalonil and carvacrol, bromine bacterium
The mass fraction ratio of nitrile and carvacrol is 50:1~1:10.
2. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and carvacrol
For：30:1~1:1.
3. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and carvacrol
For：19:1~9:1.
4. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and carvacrol
For：19:1.
5. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and carvacrol
For：12:1.
6. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and carvacrol
For：9:1.
7. bactericidal composition according to claim 1, the weight of active component is the 0.1%~60% of composition total weight,
Remaining is insecticides adjuvant.
8. bactericidal composition according to claim 5, it is characterised in that：The dosage form of the composition is granule, moisture
One kind in shot agent, microemulsion.
9. the bactericidal composition described in claim 4, microemulsion preparation method is as follows：Take 12 parts of bromothalonils, 1 part of carvacrol, 7
Part n-butanol, 5 parts of glycerine, 15 parts of sec-Butyl Acetates, 5 parts of triphenoethyl benzene phenol polyethenoxy ether phosphate, mentioned component are mixed
After closing uniformly, 55 parts of deionized waters of addition are placed in container to be sheared 30 minutes with 6000 turns of cutter per minute, that is, makes 12% bromine
1% carvacrol micro-emulsion of bacterium nitrile.
10. the bactericidal composition described in claim 1 to 6 any one is total for preventing grey mould fruit rot of strawberry, increase strawberry root system
The purposes of amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810221766.0A CN108293998A (en) | 2018-03-18 | 2018-03-18 | bactericidal composition containing bromothalonil and carvacrol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810221766.0A CN108293998A (en) | 2018-03-18 | 2018-03-18 | bactericidal composition containing bromothalonil and carvacrol |
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| Publication Number | Publication Date |
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| CN108293998A true CN108293998A (en) | 2018-07-20 |
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ID=62850028
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|---|---|---|---|
| CN201810221766.0A Pending CN108293998A (en) | 2018-03-18 | 2018-03-18 | bactericidal composition containing bromothalonil and carvacrol |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101715776A (en) * | 2010-01-07 | 2010-06-02 | 青岛星牌作物科学有限公司 | Bactericidal composition containing bromothalonil and thiophanate-methyl, and application thereof |
| CN103039470A (en) * | 2013-01-15 | 2013-04-17 | 福建凯立生物制品有限公司 | Bactericide composition and application thereof |
| CN104488870A (en) * | 2014-12-24 | 2015-04-08 | 陕西汤普森生物科技有限公司 | Pesticide composition containing bromothalonil |
-
2018
- 2018-03-18 CN CN201810221766.0A patent/CN108293998A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101715776A (en) * | 2010-01-07 | 2010-06-02 | 青岛星牌作物科学有限公司 | Bactericidal composition containing bromothalonil and thiophanate-methyl, and application thereof |
| CN103039470A (en) * | 2013-01-15 | 2013-04-17 | 福建凯立生物制品有限公司 | Bactericide composition and application thereof |
| CN104488870A (en) * | 2014-12-24 | 2015-04-08 | 陕西汤普森生物科技有限公司 | Pesticide composition containing bromothalonil |
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Application publication date: 20180720 |