CN108142418A - Bactericidal composition containing bromothalonil and propamidine - Google Patents
Bactericidal composition containing bromothalonil and propamidine Download PDFInfo
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- CN108142418A CN108142418A CN201810221745.9A CN201810221745A CN108142418A CN 108142418 A CN108142418 A CN 108142418A CN 201810221745 A CN201810221745 A CN 201810221745A CN 108142418 A CN108142418 A CN 108142418A
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- Prior art keywords
- propamidine
- bromothalonil
- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/52—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing groups, e.g. carboxylic acid amidines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of containing the bactericidal composition that active ingredient is bromothalonil and propamidine, including usual auxiliaries, bromothalonil and propamidine, the quality parts ratio of bromothalonil and propamidine is 30:1~1:10, preferably than being 20:1~1:1, more preferably than being 9:1~5:1.Bromothalonil and there is synergistic effect to pathogen fungi and crop root increase after being compounded in certain proportion with propamidine, suitable for prevention by the fungus-caused crop disease of pathogen and enhancing crop root.
Description
Technical field
The invention belongs to synergetic pesticide composition fields, and in particular to a kind of containing active constituent bromothalonil and propamidine
Composition pesticide.
Technical background
Bromothalonil, english common name bromothalonil, chemical formula C6H6Br2N2, chemical name 1,2'- bis- bromo- 2,
4- dicyanobutanes.Bromothalonil is a kind of wide spectrum, low toxicity, mould proof, algae-killing bactericidal agent.It can inhibit and root out bacterium, fungi and algae
The growth of class has corps diseases preferable control effect, especially has special efficacy to anthracnose.
Propamidine, english common name Propamidine, chemical name 1,3- bis- (4- amidinophenoxies) propane belong to virtue
Fragrant two amidine compounds.Propamidine is systemic fungicide, can be had protection in plant body absorption, distribution and metabolism and control
Treatment acts on, and is mainly used for preventing the crop gray mold as caused by Botrytis pathogen.
It is one of prevention most effective chemical means of phytopathogen using chemical agent；With the novel pesticide of no cross resistance
It is a good solution to carry out controlling plant diseases；But one novel pesticide of exploitation needs to screen a chemical combination up to ten thousand at present
Object, hundred million dollars of cost 1.2-1.5, the development cycle is 5-10, it is difficult to the speed that the upper pathogen caught up with develops immunity to drugs；It is other
Method such as crop structure adjustment, different pesticide rotations etc., in actual mechanical process, it is difficult to play apparent effect.
Develop new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research
Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.
The synergistic combination of bromothalonil and propamidine has not been reported, and the mechanism of action and action character of bromothalonil and propamidine are not
Together.
Invention content
The present invention is intended to provide a kind of Synergistic bactericidal composition containing bromothalonil and propamidine, convenient for crop disease resistance
Management, health control and reduction Pesticide use amount.
The invention is realized by the following technical scheme：
The bactericidal composition containing bromothalonil and propamidine, active constituent be bromothalonil and propamidine, preferably
The mass fraction ratio of bromothalonil and propamidine is 30:1~1:10.
Further preferred bromothalonil and the mass fraction ratio of propamidine are 20:1~1:1.
Further preferred bromothalonil and the mass fraction ratio of propamidine are 9:1~5:1.
Further preferred bromothalonil and the mass fraction ratio of propamidine are 9:1.
Further preferred bromothalonil and the mass fraction ratio of propamidine are 7:1.
Further preferred bromothalonil and the mass fraction ratio of propamidine are 5:1.
The bactericidal composition containing bromothalonil and propamidine, in addition to containing active constituent bromothalonil and propamidine, also
Contain auxiliary agent；The weight of active component is the 0.1%~60% of composition total weight, remaining is insecticides adjuvant.
The composition pesticide, being processed into microemulsion, water dispersible granules, granule etc., agriculturally common dosage form is just
In agriculturally using, aqueous suspension agent, aqueous emulsion, dispersible oil-suspending agent, missible oil, suspension emulsion, wettable powder can also be processed into
Other formulations of pesticide such as agent.
The granule dosage form weight percent forms：Bromothalonil 0.1~10%, propamidine 0.01~10% divide
Powder 0.1~10%, wetting agent 0.1~10%, binding agent 0.1~10%, carrier complement to 100%.Specifically production stage is：
Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, then
It adds in fluidized-bed granulation dryer and is granulated, dries, sieve, the granule of corresponding weight percentage is made.
The dosage form of water dispersible granule weight percent forms：Bromothalonil 0.1~50%, propamidine 0.01~
10%th, dispersant 0.1~15%, disintegrant 0.1~15%, wetting agent 0.1~5%, solid carrier complements to 100%.Specifically
Production stage is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, is then added in
It is granulated, dried, sieved in fluidized-bed granulation dryer, the water dispersible granules of corresponding weight percentage are made.
The micro-emulsion form weight percent forms：Bromothalonil 0.1~30%, propamidine 0.01~10% divide
Powder 0.1~10%, emulsifier 2~15%, solvent 0.1~30%, antifreezing agent 0.1~5%, deionized water complements to 100%.
Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, after active ingredient and auxiliary agent dissolving, is placed in container and uses
Cutter is sheared 5 minutes~2 hours, obtains the microemulsion of corresponding weight percentage.
The antifreezing agent can be one or more of in glycerine, propylene glycol, diethylene glycol (DEG), urea etc..
The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur
One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..
The emulsifier can be agriculture breast 33#, agriculture breast 34#, agriculture breast 500#, agriculture breast 600#, Nongru-700 #, agriculture breast 1601#,
Agriculture breast 1602#, T60, S80, TX-10, OP-10, NP-10, Nonyl pheno (EO=10) ether phosphate, triphenoethyl benzene
One kind in phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane.
The dispersant can be APES formaldehyde condensation product, naphthalenesulfonate formaldehyde condensation compound, to first
Oxygroup fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, alkyl phenol polyoxyethylene ether sulfate, alkyl benzene sulphonate
Calcium salt, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyethylene glycol stearate, sorbose
One or more of alcohol oleate, nekal etc..
The disintegrant can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium,
Crospovidone, chitosan, sodium alginate sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc.
One or more of.
The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon, clay,
One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..
The binding agent can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine
Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin,
One or more of rosin, wood powder etc..
The solvent can be toluene, dimethylbenzene, trimethylbenzene, solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropanol,
N-butanol, n-octyl alcohol, n-amyl alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N-Methyl pyrrolidone, acetonitrile, dichloromethane
Alkane, ethyl acetate, methyl oleate, dibutyl phthalate, sec-Butyl Acetate.
The deionized water is industrial deionized water.
It is found by experiment that, bromothalonil is used in mixed way with propamidine to pythium (Pythium), Phytophthora
(Phytophthora), Peronospora (Peronospora), Pseudoperonospora (Pseudoperonospora), Sphaerotheca
(Sphaerotheca), Blumeria (Blumiria), Erysiphe (Erysiphe), Gibberella (Gibberella),
Sclerotinia (Sclerotinia), grape Sclerotinia (Botryotinia), Puccinia (Puccinia), Tilletia
(Tilletia), glue Rust (Gymnosporzngium), Phakopsora (Phakopsora), Ustilago (Ustilago),
Pyrenomycetes category (Rhizoctonia), Verticillium (Verticillium), Alternaria (Alternaria), Pyricularia Sacc.
(Pyriculara), Botrytis (Botrytis), Cercospora (Cercospora), Fusarium (Fusarium), colletotrichum
(Colletotrichum) etc. there is synergistic effect.
The present invention has the advantages that：
1st, the composition pesticide provided by the invention containing active constituent bromothalonil and propamidine, bromothalonil exist with propamidine
There is synergistic effect to the toxicity of target pathogen in the range of certain proportion, such as strawberry anthrax-bacilus (Colletotrichum
Fragariae Brooks), Botrytis cinerea (Botrytis cinerea).
2nd, composition pesticide of the present invention has synergistic effect to target pathogen, it is possible to reduce Pesticide use amount reduces agriculture
The pollution of control of crop disease cost, mitigation to environment.
3rd, present composition active constituent bromothalonil and propamidine increase strawberry root system total amount in the range of certain proportion
Add with synergistic effect.
Specific embodiment
According to the abundant methods of Sun Yun, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association
Same antagonism, 80 ＜ CTC ＜ 120 are joint action of antagonism, and CTC >=120 are synergistic function.Survey toxicity index
(ATI)=(EC of standard agent50The EC of/reagent agent50)×100；The toxicity index of theoretical toxicity index TTI=A medicaments ×
In mixture in toxicity index × mixture of the percentage composition+B medicaments of A medicaments B medicaments percentage composition；Co-toxicity coefficient (CTC)=
[mixture actual measurement toxicity index (ATI)/mixture theoretical toxicity index (TTI)] × 100
Embodiment one：Bromothalonil propamidine is to strawberry anthrax-bacilus (Colletotrichumfragariae Brooks)
Toxicity Determination, subjects pick up from the pathogen strawberry anthrax-bacilus (Colletotrichum of the Strawberry anthracnose in field
fragariaeBrooks)。
Table 1：Bromothalonil propamidine is to the interior of strawberry anthrax-bacilus (Colletotrichumfragariae Brooks)
Toxicity test result (mycelia growth method).
As shown in Table 1, bromothalonil and propamidine mixture are 30:1~1:Between 10, to strawberry anthrax-bacilus
(Colletotrichumfragariae Brooks) has synergistic effect, and co-toxicity coefficient is more than 130；Bromothalonil and propane
Amidine mixture is 20:1~1:Strawberry anthrax-bacilus (Colletotrichumfragariae Brooks) is made with synergy between 1
With co-toxicity coefficient is more than 150；Bromothalonil is with propamidine mixture 9:1~5:To strawberry anthrax-bacilus between 1
(ColletotrichumfragariaeBrooks) there is apparent synergistic effect, co-toxicity coefficient is more than 210；And bromine bacterium
Nitrile is with propamidine mixture 50:1 and 1:20~60 pairs of strawberry anthrax-bacilus (Colletotrichum fragariaeBrooks) are altogether
Malicious coefficient is 120 hereinafter, without synergistic effect.
Embodiment two：Bromothalonil propamidine is to the Toxicity Determination of Botrytis cinerea (Botrytis cinerea), examination
Test the grey mould fruit rot of strawberry pathogen Botrytis cinerea (Botrytis cinerea) (mycelia growth method) that object picks up from field.
Table 2：Bromothalonil propamidine is to the The Toxicity Determination result of Botrytis cinerea (Botrytis cinerea).
As shown in Table 2, bromothalonil and propamidine mixture are 30:1~1:Between 10, to Botrytis cinerea (Botrytis
Cinerea) there is apparent synergistic effect, co-toxicity coefficient is more than 120；Bromothalonil is with propamidine mixture 20:1~1:1
Between, there is apparent synergistic effect to Botrytis cinerea (Botrytis cinerea), co-toxicity coefficient is more than 140；Bromine bacterium
Nitrile is with propamidine mixture 9:1~5:Between 1, there is apparent synergistic effect to Botrytis cinerea (Botrytis cinerea),
Co-toxicity coefficient is more than 180；And bromothalonil and propamidine mixture are 70:1 and 1:20~60 couples of Botrytis cinerea (Botrytis
Cinerea) has no synergistic effect, co-toxicity coefficient is below 120.
Three bromothalonil of embodiment influences to test with propamidine on strawberry root system
Colby equatioies are used to determine desired effect (Colby, the S.R.Weeds1967,15,20- of mixture
22.Calculation of the synergistic and antagonistic response of herbicide
combinations)：
Following equatioies are used to calculate the desired value of the mixture containing two kinds of active components A and B：
In formula：
The effect of active components A of identical (dosage) concentration used in the mixture that A=is observed；
The effect of active constituent B of identical (dosage) concentration used in the mixture that B=is observed.
When the active actual observation value (E) of concentration used in mixture (dosage) is more than desired value (E0) when, mixture is shown as
There is unexpected synergistic effect to target.
Test (the stem of 3 bromothalonil of table and the propamidine mixing Herba Hyperici elodeoidis certain kind of berries (milk strawberry) root system total amount (dry weight) increment rate
Foliar spray mist, every plant of spray amount is 2 milliliters, is tested within 30 days after medicine)
The data result that table 3 is recorded shows bromothalonil administration dosage (cauline leaf spraying) for 2 milliliters of 150 mg/kg and third
Alkane amidine administration dosage (cauline leaf spraying) increases for 120 mg/kg, 2 milliliters of root systems to strawberry (milk strawberry), and there is collaboration to make
With the weight of root system increment rate that mixture observes is more than desired weight of root system increment rate 11%.
0.9% bromothalonil of example IV, 0.1% propamidine granule
Weigh 0.9% bromothalonil, 0.1% propamidine, 1% chitosan, 1% corn flour, 4% sawdust, surplus diatomite.On
It states raw material to be uniformly mixed in mixed cylinder, by squeezing, being granulated, drying, and 0.9% bromothalonil is made in screened step
0.1% propamidine granule.
5 27% bromothalonil of embodiment, 3% propamidine water dispersible granules
Weigh 27% bromothalonil, 3% propamidine, 12% sodium butylnaphthalenesulfonate, 3% sodium naphthalene sulfonate, 5% spaonin powder, 2% carbon
Sour hydrogen sodium, surplus precipitated calcium carbonate.Above-mentioned raw materials are uniformly mixed in mixed cylinder, by squeezing, being granulated, drying, and screened
27% bromothalonil, 3% propamidine water dispersible granules are made in step.
6 18% bromothalonil of embodiment, 2% propamidine microemulsion
Take 18 parts of bromothalonils, 2 parts of propamidines, 15 parts of n-butanols, 5 parts of ethyl acetate, 10 parts of sec-Butyl Acetates, epoxy chloropropionate
15 parts of alkane, after mixing, 35 parts of deionized waters of addition are placed in container is cut mentioned component with 8000 turns per minute of cutter
It cuts 30 minutes, that is, makes 18% bromothalonil, 2% propamidine microemulsion.
Seven Application Example of embodiment
4 18% bromothalonil of table, the 2% propamidine microemulsion prevention grey mould fruit rot of strawberry test of pesticide effectiveness (greenhouse, cauline leaf spraying)
。
Claims (10)
1. the bactericidal composition containing bromothalonil and propamidine, it is characterised in that：Active constituent be bromothalonil and propamidine, bromine bacterium
The mass fraction ratio of nitrile and propamidine is 30:1~1:10.
2. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and propamidine
For：20:1~1:1.
3. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and propamidine
For：9:1~5:1.
4. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and propamidine
For：9:1.
5. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and propamidine
For：7:1.
6. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and propamidine
For：5:1.
7. bactericidal composition according to claim 1, the weight of active component is the 0.1%~60% of composition total weight,
Remaining is insecticides adjuvant.
8. bactericidal composition according to claim 5, it is characterised in that：The dosage form of the composition is granule, moisture
One kind in shot agent, microemulsion.
9. the bactericidal composition described in claim 4, microemulsion preparation method is as follows：Take 18 parts of bromothalonils, 2 parts of propamidines,
15 parts of n-butanols, 5 parts of ethyl acetate, 10 parts of sec-Butyl Acetates, 15 parts of epoxychloropropane, mentioned component after mixing, add in
35 parts of deionized waters are placed in container and are sheared 30 minutes with 8000 turns per minute of cutter, that is, make 18% bromothalonil, 2% propamidine
Microemulsion.
10. the bactericidal composition described in claim 1 to 6 any one is total for preventing grey mould fruit rot of strawberry, increase strawberry root system
The purposes of amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810221745.9A CN108142418A (en) | 2018-03-18 | 2018-03-18 | Bactericidal composition containing bromothalonil and propamidine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810221745.9A CN108142418A (en) | 2018-03-18 | 2018-03-18 | Bactericidal composition containing bromothalonil and propamidine |
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| Publication Number | Publication Date |
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| CN108142418A true CN108142418A (en) | 2018-06-12 |
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ID=62456575
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810221745.9A Pending CN108142418A (en) | 2018-03-18 | 2018-03-18 | Bactericidal composition containing bromothalonil and propamidine |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1930972A (en) * | 2005-09-15 | 2007-03-21 | 南京第一农药有限公司 | Germicide composition containing propamidine and myclobutanil and its application |
-
2018
- 2018-03-18 CN CN201810221745.9A patent/CN108142418A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1930972A (en) * | 2005-09-15 | 2007-03-21 | 南京第一农药有限公司 | Germicide composition containing propamidine and myclobutanil and its application |
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Application publication date: 20180612 |