CN108293997A - bactericidal composition containing bromothalonil and eugenol - Google Patents
bactericidal composition containing bromothalonil and eugenol Download PDFInfo
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- CN108293997A CN108293997A CN201810221765.6A CN201810221765A CN108293997A CN 108293997 A CN108293997 A CN 108293997A CN 201810221765 A CN201810221765 A CN 201810221765A CN 108293997 A CN108293997 A CN 108293997A
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- eugenol
- bromothalonil
- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/34—Nitriles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of containing the bactericidal composition that active ingredient is bromothalonil and eugenol, including usual auxiliaries, bromothalonil and eugenol, and the quality parts ratio of bromothalonil and eugenol is 40:1~1:20, preferably than being 20:1~1:1, more preferably than being 15:1~6:1.Bromothalonil and there is synergistic effect to pathogen fungi and crop root increase after being compounded in certain proportion with eugenol, is suitable for prevention by the fungus-caused crop disease of pathogen and enhancing crop root.
Description
Technical field
The invention belongs to synergetic pesticide composition fields, and in particular to one kind containing active constituent bromothalonil and eugenol
Composition pesticide.
Technical background
Bromothalonil, english common name bromothalonil, chemical formula C6H6Br2N2, chemical name 1,2'- bis- bromo- 2,
4- dicyanobutanes.Bromothalonil is a kind of wide spectrum, low toxicity, mould proof, algae-killing bactericidal agent.It can inhibit and root out bacterium, fungi and algae
The growth of class has preferable control effect to corps diseases, especially has special efficacy to anthracnose.
Eugenol, english common name Eugenol, chemical name Coryophyllic acid, eugenol doctor
For antibacterial, anti-inflammatory on medicine, agriculturally can be used for preventing the crop diseases such as crop gray mold, banded sclerotial blight, sigatoka.
It is one of prevention most effective chemical means of phytopathogen using chemical agent；With the novel pesticide of not cross resistance
It is a good solution to carry out controlling plant diseases；But one novel pesticide of exploitation needs to screen a chemical combination up to ten thousand at present
Object, hundred million dollars of cost 1.2-1.5, the development cycle is 5-10, it is difficult to the speed that the upper pathogen caught up with develops immunity to drugs；It is other
Method such as crop structure adjustment, different pesticide rotations etc., in actual mechanical process, it is difficult to play apparent effect.
Develop new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research
Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.
The synergistic combination of bromothalonil and eugenol has not been reported, and the mechanism of action and effect of bromothalonil and eugenol are special
Point is different.
Invention content
The present invention is intended to provide a kind of Synergistic bactericidal composition containing bromothalonil and eugenol, anti-convenient for crop disease
Property management, health control and reduce Pesticide use amount.
The invention is realized by the following technical scheme：
The bactericidal composition containing bromothalonil and eugenol, active constituent be bromothalonil and eugenol, it is excellent
The bromothalonil of choosing and the mass fraction ratio of eugenol are 40:1~1:20.
The mass fraction ratio of further preferred bromothalonil and eugenol is 20:1~1:1.
The mass fraction ratio of further preferred bromothalonil and eugenol is 15:1~6:1.
The mass fraction ratio of further preferred bromothalonil and eugenol is 15:1.
The mass fraction ratio of further preferred bromothalonil and eugenol is 9:1.
The mass fraction ratio of further preferred bromothalonil and eugenol is 6:1.
The bactericidal composition containing bromothalonil and eugenol removes and contains active constituent bromothalonil and eugenol
Outside, also contain auxiliary agent；The weight of active component is the 0.1%~60% of composition total weight, remaining is insecticides adjuvant.
The composition pesticide, being processed into microemulsion, water dispersible granules, granule etc., agriculturally common dosage form is just
In agriculturally using, other formulations of pesticide such as aqueous suspension agent, aqueous emulsion, dispersible oil-suspending agent can also be processed into.
The granule dosage form weight percent group becomes：Bromothalonil 0.01~30%, eugenol 0.01~30%,
Dispersant 0.1~15%, wetting agent 0.1~10%, binder 0.1~14%, carrier complement to 100%.Specific production stage
For：Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, so
It is added in fluidized-bed granulation dryer afterwards and is granulated, dries, sieve, the granule of corresponding weight percentage is made.
The dosage form of water dispersible granule weight percent group becomes：Bromothalonil 0.01~50%, eugenol 0.01~
10%, dispersant 0.1~13%, disintegrant 0.1~13%, wetting agent 0.1~5%, solid carrier complements to 100%.Specifically
Production stage is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, is then added
It is granulated, dried, sieved in fluidized-bed granulation dryer, the water dispersible granules of corresponding weight percentage are made.
The micro-emulsion form weight percent group becomes：Bromothalonil 0.01~30%, eugenol 0.01~10%,
Dispersant 0.1~13%, emulsifier 1-8%, solvent 0.1~30%, antifreezing agent 0.1~5%, deionized water complements to 100%.
Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, after active ingredient and auxiliary agent dissolving, is placed in container and uses
Cutter is sheared -2 hours 5 minutes, and the microemulsion of corresponding weight percentage is obtained.
The antifreezing agent can be one or more of in glycerine, propylene glycol, diethylene glycol (DEG), urea etc..
The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur
One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..
The emulsifier can be agriculture breast 33#, agriculture breast 34#, agriculture breast 500#, agriculture breast 600#, Nongru-700 #, agriculture breast 1601#,
Agriculture breast 1602#, T60, S80, TX-10, OP-10, NP-10, Nonyl pheno (EO=10) ether phosphate, triphenoethyl benzene
One or more of phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane.
The dispersant can be APES formaldehyde condensation product, naphthalenesulfonate formaldehyde condensation compound, to first
Oxygroup fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, alkyl phenol polyoxyethylene ether sulfate, alkyl benzene sulphonate
Calcium salt, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyethylene glycol stearate, sorbose
One or more of alcohol oleate, nekal etc..
The disintegrant can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium,
Crospovidone, chitosan, sodium alginate sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc.
One or more of.
The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon, clay,
One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..
The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine
Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin,
One or more of rosin, wood powder etc..
The solvent can be toluene, dimethylbenzene, trimethylbenzene, solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropanol,
N-butanol, n-octyl alcohol, n-amyl alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N-Methyl pyrrolidone, acetonitrile, dichloromethane
Alkane, ethyl acetate, methyl oleate, dibutyl phthalate, sec-Butyl Acetate.
The deionized water is industrial deionized water.
It is found by experiment that, bromothalonil is used in mixed way with eugenol to pythium (Pythium), Phytophthora
(Phytophthora), Peronospora (Peronospora), Pseudoperonospora (Pseudoperonospora), Sphaerotheca
(Sphaerotheca), Blumeria (Blumiria), Erysiphe (Erysiphe), Gibberella (Gibberella),
Sclerotinia (Sclerotinia), grape Sclerotinia (Botryotinia), Puccinia (Puccinia), Tilletia
(Tilletia), glue Rust (Gymnosporzngium), Phakopsora (Phakopsora), Ustilago (Ustilago),
Pyrenomycetes category (Rhizoctonia), Verticillium (Verticillium), Alternaria (Alternaria), Pyricularia Sacc.
(Pyriculara), Botrytis (Botrytis), Cercospora (Cercospora), Fusarium (Fusarium), colletotrichum
(Colletotrichum) etc. there is synergistic effect.
The present invention has the advantages that：
1, the composition pesticide provided by the invention containing active constituent bromothalonil and eugenol, bromothalonil and clove tree
Phenol has synergistic effect within the scope of certain proportion to the toxicity of target pathogen, such as strawberry anthrax-bacilus
(ColletotrichumfragariaeBrooks), Botrytis cinerea (Botrytis cinerea).
2, composition pesticide of the present invention has synergistic effect to target pathogen, it is possible to reduce Pesticide use amount reduces agriculture
The pollution of control of crop disease cost, mitigation to environment.
3, present composition active constituent bromothalonil and eugenol within the scope of certain proportion to strawberry root system total amount
Increasing has synergistic effect.
Specific implementation mode
According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association
Same antagonism, 80 ＜ CTC ＜ 120 are joint action of antagonism, and CTC >=120 are synergistic function.Survey toxicity index
(ATI)=(EC of standard agent50The EC of/reagent agent50)×100；The toxicity index of theoretical toxicity index TTI=A medicaments ×
In mixture in toxicity index × mixture of the percentage composition+B medicaments of A medicaments B medicaments percentage composition；Co-toxicity coefficient (CTC)=
[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100
Embodiment one：Bromothalonil eugenol is to strawberry anthrax-bacilus (Colletotrichumfragariae Brooks)
Toxicity Determination, subjects pick up from the pathogen strawberry anthrax-bacilus (Colletotrichum of the Strawberry anthracnose in field
fragariaeBrooks)。
Table 1：Room of the bromothalonil eugenol to strawberry anthrax-bacilus (Colletotrichumfragariae Brooks)
Interior virulence measurement result (mycelia growth method).
As shown in Table 1, bromothalonil and eugenol mixture are 40:1~1:Between 20, to strawberry anthrax-bacilus
(Colletotrichumfragariae Brooks) has synergistic effect, and co-toxicity coefficient is 120 or more；Bromothalonil and fourth
Fragrant phenol mixture is 20:1~1:Strawberry anthrax-bacilus (Colletotrichumfragariae Brooks) is made with synergy between 1
With co-toxicity coefficient is 130 or more；Bromothalonil is with eugenol mixture 15:1~1:To strawberry anthrax-bacilus between 1
(Colletotrichumfragariae Brooks) has apparent synergistic effect, and co-toxicity coefficient is 170 or more；And bromine bacterium
Nitrile is with eugenol mixture 60:1 and 1:Poison is 40 pairs of strawberry anthrax-bacilus (ColletotrichumfragariaeBrooks) altogether
Number is 120 hereinafter, without synergistic effect.
Embodiment two：Bromothalonil eugenol to the Toxicity Determination of Botrytis cinerea (Botrytis cinerea),
Subjects pick up from the grey mould fruit rot of strawberry pathogen Botrytis cinerea (Botrytis cinerea) (mycelia growth method) in field.
Table 2：The Toxicity Determination result of the bromothalonil eugenol to Botrytis cinerea (Botrytis cinerea).
As shown in Table 2, bromothalonil and eugenol mixture are 40:1~1:Between 20, to Botrytis cinerea (Botrytis
Cinerea) there is apparent synergistic effect, co-toxicity coefficient is 120 or more；Bromothalonil is with eugenol mixture 20:1~1:
Between 1, there is apparent synergistic effect to Botrytis cinerea (Botrytis cinerea), co-toxicity coefficient is 140 or more；Bromine bacterium
Nitrile is with eugenol mixture 15:1~6:Between 1, Botrytis cinerea (Botrytis cinerea) is made with apparent synergy
With co-toxicity coefficient is 180 or more；And bromothalonil and eugenol mixture are 60:1 and 1:40 couples of Botrytis cinerea (Botrytis
Cinerea) has no synergistic effect, co-toxicity coefficient is below 120.
Three bromothalonil of embodiment influences to test with eugenol on strawberry root system
Colby equatioies are used to determine desired effect (Colby, the S.R.Weeds1967,15,20- of mixture
22.Calculation of the synergistic and antagonistic response of herbicide
combinations)：
Following equatioies are used to calculate the desired value of the mixture containing two kinds of active components A and B：
In formula：
The effect of active components A of identical (dosage) concentration used in the mixture that A=is observed；
The effect of active constituent B of identical (dosage) concentration used in the mixture that B=is observed.
The active actual observation value (E) of the concentration (dosage) used in the mixture is more than desired value (E0) when, mixture is shown as
There is unexpected synergistic effect to target.
The test of 3 bromothalonil of table and the eugenol mixing Herba Hyperici elodeoidis certain kind of berries (milk strawberry) root system total amount (dry weight) increment rate
(cauline leaf is sprayed, and every plant of spray amount is 2 milliliters, is tested within 30 days after medicine)
The data result that table 3 is recorded shows that bromothalonil administration dosage (cauline leaf spraying) is 2 milliliters of 150 mg/kg and fourth
Eugenol administration dosage (cauline leaf spraying) is that root system of 2 milliliters of 150 mg/kg to strawberry (milk strawberry) increases with collaboration
Effect, the weight of root system increment rate that mixture observes are more than desired weight of root system increment rate 13%.
9% bromothalonil of example IV, 1% eugenol granule
Weigh 9% bromothalonil, 1% eugenol, 4% glucose, 5% wheat bran, 2% rice chaff, surplus attapulgite.It is above-mentioned
Raw material is uniformly mixed in mixed cylinder, and by extruding, granulation, drying, and 9% bromothalonil, 1% fourth is made in screened step
Fragrant phenol granule.
5 30% bromothalonil of embodiment, 2% eugenol water dispersible granules
Weigh 30% bromothalonil, 2% eugenol, 6% sodium lignin sulfonate, 3% chitosan, 5% spaonin powder, 3% carbon
Sour hydrogen sodium, surplus white carbon.Above-mentioned raw materials are uniformly mixed in mixed cylinder, by extruding, granulation, drying, and screened step
30% bromothalonil, 2% eugenol water dispersible granules are made.
6 15% bromothalonil of embodiment, 1% eugenol microemulsion
Take 15 parts of bromothalonils, 1 part of eugenol, 5 parts of ethylene glycol, 5 parts of glycerine, 24 parts of sec-Butyl Acetates, poly alkyl alcohol
5 parts of ethylene oxide ether, 5 parts of chitosan, mentioned component after mixing, are added 40 parts of deionized waters and are placed in container with per minute
6000 turns of cutter is sheared 20 minutes, and 15% bromothalonil, 1% eugenol microemulsion is obtained.
Seven Application Example of embodiment
4 15% bromothalonil of table, 1% eugenol microemulsion prevents the grey mould fruit rot of strawberry test of pesticide effectiveness (greenhouse, cauline leaf spraying)
Claims (10)
1. the bactericidal composition containing bromothalonil and eugenol, it is characterised in that：Effective ingredient be bromothalonil and eugenol,
The mass fraction ratio of bromothalonil and eugenol is 40:1~1:20.
2. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and eugenol
For：20:1~1:1.
3. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and eugenol
For：15:1~6:1.
4. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and eugenol
For：15:1.
5. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and eugenol
For：9:1.
6. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of bromothalonil and eugenol
For：6:1.
7. bactericidal composition according to claim 1, the weight of active component is the 0.1%~60% of composition total weight,
Remaining is insecticides adjuvant.
8. bactericidal composition according to claim 5, it is characterised in that：The dosage form of the composition is granule, moisture
One kind in shot agent, microemulsion.
9. the bactericidal composition described in claim 4, microemulsion preparation method is as follows：Take 15 parts of bromothalonils, 1 portion of clove tree
Phenol, 5 parts of ethylene glycol, 5 parts of glycerine, 24 parts of sec-Butyl Acetates, 5 parts of fatty alcohol polyoxyethylene ether, 5 parts of chitosan, mentioned component
After mixing, 40 parts of deionized waters of addition are placed in container is sheared 20 minutes with 6000 turns of cutter per minute, is obtained
15% bromothalonil, 1% eugenol microemulsion.
10. the bactericidal composition described in claim 1 to 6 any one is total for preventing grey mould fruit rot of strawberry, increase strawberry root system
The purposes of amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810221765.6A CN108293997A (en) | 2018-03-18 | 2018-03-18 | bactericidal composition containing bromothalonil and eugenol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810221765.6A CN108293997A (en) | 2018-03-18 | 2018-03-18 | bactericidal composition containing bromothalonil and eugenol |
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| CN108293997A true CN108293997A (en) | 2018-07-20 |
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| CN201810221765.6A Pending CN108293997A (en) | 2018-03-18 | 2018-03-18 | bactericidal composition containing bromothalonil and eugenol |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104488870A (en) * | 2014-12-24 | 2015-04-08 | 陕西汤普森生物科技有限公司 | Pesticide composition containing bromothalonil |
| CN107980777A (en) * | 2017-12-07 | 2018-05-04 | 广西南宁乐蕊生物科技有限责任公司 | A kind of bactericidal composition containing bromothalonil and eugenol |
-
2018
- 2018-03-18 CN CN201810221765.6A patent/CN108293997A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104488870A (en) * | 2014-12-24 | 2015-04-08 | 陕西汤普森生物科技有限公司 | Pesticide composition containing bromothalonil |
| CN107980777A (en) * | 2017-12-07 | 2018-05-04 | 广西南宁乐蕊生物科技有限责任公司 | A kind of bactericidal composition containing bromothalonil and eugenol |
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Application publication date: 20180720 |