CN108371186A - Bactericidal composition containing azalomycin F and metalaxyl - Google Patents
Bactericidal composition containing azalomycin F and metalaxyl Download PDFInfo
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- CN108371186A CN108371186A CN201810366664.8A CN201810366664A CN108371186A CN 108371186 A CN108371186 A CN 108371186A CN 201810366664 A CN201810366664 A CN 201810366664A CN 108371186 A CN108371186 A CN 108371186A
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- azalomycin
- metalaxyl
- bactericidal composition
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of containing the bactericidal composition that active ingredient is azalomycin F and metalaxyl, including usual auxiliaries, azalomycin F and metalaxyl, and the quality parts ratio of azalomycin F and metalaxyl is 1:1~1:6, preferably than being 1:2~1:4.Azalomycin F and there is synergistic effect to pathogen fungi after being compounded in certain proportion with metalaxyl, is suitable for prevention by the fungus-caused crop disease of pathogen.
Description
Technical field
The invention belongs to synergetic pesticide composition fields, and in particular to one kind containing active constituent azalomycin F and first frost
The composition pesticide of spirit.
Background technology
Azalomycin F (Azalomycin F), belongs to Macrocyclic lactone compounds, has broad-spectrum antifungal activity, simultaneously also
There are inhibition or killing effect, Chinese patent CN101792474B to describe azalomycin F agriculturally various agricultural pest and disease damage
Purposes, can be used for preventing banana blight and crop root knot nematode disease.
Metalaxyl (Metalaxyl), chemical name D, L-N- (2,6- 3,5-dimethylphenyl)-N- (2- methoxyl groups acetyl) third ammonia
Sour methyl esters, new and effective systemic fungicide.Can interior suction enter in plant, it is water-soluble more much higher than general fungicide.Metalaxyl
Phenyl amide series bactericidal agent, interior suction and penetration are very strong, after dispenser 30 minutes can in plant up and down Bidirectional Conduction,
There are protection and therapeutic effect to disease plant, and the drug effect duration is long, the main synthesis for inhibiting germ mycelia vivo protein makes
Its nutritional deficiency is unable to normal growth and dead, to Pseudoperonospora cubensis, phytophthora germ and the microbial various crop downy mildew of maize ear rot
The droop of disease, melon and fruit solanaceous vegetable class is effective.
Fusarium (Fusarium) pathogen causes various plant diseases extensively.Fusorium moniliforme Sheldon (Fusarium
Moniliforme Sheld) cause bakanae disease of rice；F.graminearum schw (Fusarium graminearun Schaabe) causes small
Wheat head blight；Fusarium oxysporum (Fusarium oxysporum) causes various crop disease, as Fusarium oxysporum cucumber specially changes
Type (Fusarium oxysporum (Schl) F.sp.cucumerinum Owen) causes cucumber fusarium axysporum, Fusarium oxysporum bar
Cause banana blight (banana Panama wilt disease) by horse specialized form (Fusarium oxysporum f.sp.cubense).
It is one of prevention most effective chemical means of phytopathogen using chemical agent；With the novel pesticide of not cross resistance
It is a good solution to carry out controlling plant diseases；But one novel pesticide of exploitation needs to screen a chemical combination up to ten thousand at present
Object, hundred million dollars of cost 1.2-1.5, the development cycle is 5-10, it is difficult to the speed that the upper pathogen caught up with develops immunity to drugs；It is other
Method such as crop structure adjustment, different pesticide rotations etc., in actual mechanical process, it is difficult to play apparent effect.
Develop new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research
Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.
The synergistic combination of azalomycin F and metalaxyl has not been reported, the mechanism of action and effect of azalomycin F and metalaxyl
Feature is different.
Invention content
The present invention is intended to provide a kind of Synergistic bactericidal composition containing azalomycin F and metalaxyl, is convenient for crop disease
Resistance management, health control and reduction Pesticide use amount.
The invention is realized by the following technical scheme：
The bactericidal composition containing azalomycin F and metalaxyl, active constituent be azalomycin F and metalaxyl,
The mass fraction ratio of preferred azalomycin F and metalaxyl is 1:1~1:6.
The mass fraction ratio of further preferred azalomycin F and metalaxyl is 1:2~1:4.
The mass fraction ratio of further preferred azalomycin F and metalaxyl is 1:2.
The mass fraction ratio of further preferred azalomycin F and metalaxyl is 1:3.
The mass fraction ratio of further preferred azalomycin F and metalaxyl is 1:4.
The bactericidal composition containing azalomycin F and metalaxyl removes and contains active constituent azalomycin F and metalaxyl
Outside, also contain auxiliary agent；The weight of active component is the 1%~30% of composition total weight, remaining is insecticides adjuvant, preferred living
Property component weight be composition total weight 3%~15%.
The composition pesticide, being processed into microemulsion, water dispersible granules, granule etc., agriculturally common dosage form is just
In agriculturally using, aqueous suspension agent, aqueous emulsion, dispersible oil-suspending agent, missible oil, suspension emulsion, wettable powder can also be processed into
Other formulations of pesticide such as agent.
The granule dosage form weight percent group becomes：Azalomycin F 1~5%, metalaxyl 1~5%, dispersant
0.1~6%, wetting agent 0.1~6%, binder 0.1~3%, carrier complement to 100%.Specifically production stage is：It is specific raw
Producing step is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, stream is then added
Change and be granulated in bed granulating and drying machine, dry, sieve, the granule of corresponding weight percentage is made.
The dosage form of water dispersible granule weight percent group becomes：Azalomycin F 1~10%, metalaxyl 1~20%,
Dispersant 0.1~12%, disintegrant 0.1~12%, wetting agent 0.1~5%, solid carrier complements to 100%.Specific production step
Suddenly it is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, fluid bed is then added
It is granulated, dried, sieved in granulating and drying machine, the water dispersible granules of corresponding weight percentage are made.
The micro-emulsion form weight percent group becomes：Azalomycin F 1~10%, metalaxyl 1~20%, dispersion
Agent 0.1~10%, emulsifier 1~15%, solvent 0.1~20%, antifreezing agent 0.1~5%, deionized water complements to 100%.Tool
Body production stage is：Active ingredient and other auxiliary agents are uniformly mixed, after active ingredient and auxiliary agent dissolving, are placed in container with cutting
It cuts machine to shear 5 minutes~2 hours, obtains the microemulsion of corresponding weight percentage.
The antifreezing agent can be one or more of in glycerine, propylene glycol, diethylene glycol (DEG), urea etc..
The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur
One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..
The emulsifier can be triphenoethyl benzene phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane, castor oil
One kind in polyoxyethylene ether, fatty alcohol polyoxy ether, aliphatic acid polyethenoxy ether, isomery alcohol.
The dispersant can be APES formaldehyde condensation product, naphthalene sulfonate, benzene sulfonate, to methoxy
Base fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fat
One kind in alcohol polyoxyethylene ether, polyethylene glycol stearate, Oleate, nekal, phosphate etc.
Or it is several.
The disintegrant can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium,
Crospovidone, chitosan, sodium alginate, sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc.
One or more of.
The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon, clay,
One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..
The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine
Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin,
One or more of rosin, wood powder etc..
The solvent can be solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropanol, n-butanol, n-octyl alcohol, positive penta
Alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N-Methyl pyrrolidone, ethyl acetate, methyl oleate, phthalic acid
Dibutyl ester, sec-Butyl Acetate.
The deionized water is industrial deionized water.
It is found by experiment that, azalomycin F is used in mixed way with metalaxyl has association to Fusarium (Fusarium) pathogen
Same-action.
The present invention has the advantages that：
1, the composition pesticide provided by the invention containing active constituent azalomycin F and metalaxyl, azalomycin F and first
The toxicity of white spirit Fusarium (Fusarium) pathogen within the scope of certain proportion has synergistic effect, such as Fusarium oxysporum
Cucumber specialized form (Fusarium oxysporum (Schl) F.sp.cucumerinum Owen).
2, composition pesticide of the present invention has synergistic effect to target pathogen, it is possible to reduce Pesticide use amount reduces agriculture
The pollution of control of crop disease cost, mitigation to environment.
Specific implementation mode
(1), raw to survey embodiment
According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association
Same antagonism, 80 ＜ CTC ＜ 120 are joint action of antagonism, and CTC >=120 are synergistic function.
Survey toxicity index (ATI)=(EC of standard agent50The EC of/reagent agent50)×100。
The virulence of the percentage composition+B medicaments of A medicaments refers in toxicity index × mixture of theoretical toxicity index TTI=A medicaments
The percentage composition of B medicaments in number × mixture.
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100.
Azalomycin F is with metalaxyl to Fusarium oxysporum cucumber specialized form (Fusarium oxysporum (Schl)
F.sp.cucumerinum Owen) Toxicity Determination, subjects pick up from the cucumber fusarium axysporum pathogen point spore sickle in field
Knife bacterium cucumber specialized form (Fusarium oxysporum (Schl) F.sp.cucumerinum Owen) (mycelia growth method).
1 azalomycin F metalaxyls of table are to Fusarium oxysporum cucumber specialized form (Fusarium oxysporum (Schl)
F.sp.cucumerinum Owen) The Toxicity Determination result.
As shown in Table 1, azalomycin F and metalaxyl mixture are 1:1~1:To Fusarium oxysporum cucumber specialized form between 6
(Fusarium oxysporum (Schl) F.sp.cucumerinum Owen) have synergistic effect, co-toxicity coefficient 130 with
On；Azalomycin F is with metalaxyl mixture 1:2~1:To Fusarium oxysporum cucumber specialized form (Fusarium between 4
Oxysporum (Schl) F.sp.cucumerinum Owen) there is preferable synergistic effect, co-toxicity coefficient is 150 or more；
And azalomycin F and metalaxyl mixture are 30:1~6:1 and 1:9~1:70 couples of (Fusarium oxysporum (Schl)
F.sp.cucumerinum Owen) the no synergistic effect of tool, co-toxicity coefficient is below 120.
(2), example of formulations
0.3% azalomycin F1.2% metalaxyl granules
Weigh 0.3% azalomycin F, 1.2% metalaxyl, 2% spaonin powder, 2% corn flour, 2% bentonite, 1% wood
Quality, surplus precipitated calcium carbonate.Above-mentioned raw materials are uniformly mixed in mixed cylinder, by extruding, granulation, drying, and screened step
Suddenly obtained 0.3% azalomycin F1.2% metalaxyl granules.
3% azalomycin F9% metalaxyl water dispersible granules
Weigh 3% azalomycin F, 9% metalaxyl, 6% sodium butylnaphthalenesulfonate, 3% polycarboxylic acids calcium, 2% chitosan, 1%
Magnesium chloride, balance kaolin.Above-mentioned raw materials are uniformly mixed in mixed cylinder, by extruding, granulation, drying, and screened step
3% azalomycin F9% metalaxyl water dispersible granules are made.
1% azalomycin F4 % metalaxyl microemulsions
1% azalomycin F, 4% metalaxyl, 6% n-amyl alcohol, 3% glycerine, 5% castor oil polyoxyethylene ether are taken, it is above-mentioned
Ingredient after mixing, is added deionized water and complements to 100%, be placed in container and shear 30 with 7000 turns of cutter per minute
Minute, obtain 1% azalomycin F4 % metalaxyl microemulsions.
(3), Application Example
Fusarium oxysporum (Fusarium oxysporum) causes various crop disease, such as Fusarium oxysporum cucumber specialized form
(Fusarium oxysporum (Schl) F.sp.cucumerinum Owen) causes cucumber fusarium axysporum；Fusarium oxysporum bar takes
Horse specialized form (Fusarium oxysporum f.sp.cubense) causes banana blight (banana Panama wilt disease).
2 1% azalomycin F4 % metalaxyl microemulsions of table prevent the cucumber fusarium axysporum test of pesticide effectiveness
2 data result of table shows 1% azalomycin F4 % metalaxyl microemulsions dosage, 20 mg/kg (active ingredient)
250 milliliter/plant pouring roots are outstanding to cucumber fusarium axysporum control effect, 10 days after medicine, 20 days control effects 80% or more, and it is excellent
In 0.5% metalaxyl, 2.5% hymexazo aqua (purchased in market, PD20096346, the limited public affairs of biological medicine company (Xiayi) share of Shanghai Shanghai connection
Department's production) 60 mg/kgs (active ingredient), 250 milliliters/plant.
Claims (10)
1. the bactericidal composition containing azalomycin F and metalaxyl, it is characterised in that：Effective ingredient is azalomycin F and first frost
The mass fraction ratio of spirit, azalomycin F and metalaxyl is 1:1~1:6.
2. bactericidal composition according to claim 1, it is characterised in that：The quality parts ratio of azalomycin F and metalaxyl
Example is 1:2~1:4.
3. bactericidal composition according to claim 1, it is characterised in that：The quality parts ratio of azalomycin F and metalaxyl
Example is 1:2.
4. bactericidal composition according to claim 1, it is characterised in that：The quality parts ratio of azalomycin F and metalaxyl
Example is 1:3.
5. bactericidal composition according to claim 1, it is characterised in that：The quality parts ratio of azalomycin F and metalaxyl
Example is 1:4.
6. bactericidal composition according to claim 1, it is characterised in that：The weight of active component is composition total weight
1%~30%, remaining is insecticides adjuvant.
7. bactericidal composition according to claim 1, it is characterised in that：The weight of active component is composition total weight
3%~15%, remaining is insecticides adjuvant.
8. bactericidal composition according to claim 1, it is characterised in that：The dosage form of the composition is granule, moisture
One kind in shot agent, microemulsion.
9. a kind of bactericidal composition containing azalomycin F and metalaxyl, it is characterised in that weight：Take 1% azalomycin F, 4%
After mixing, deionization is added in metalaxyl, 6% n-amyl alcohol, 3% glycerine, 5% castor oil polyoxyethylene ether, mentioned component
Water complements to 100%, is placed in container and is sheared 30 minutes with 7000 turns of cutter per minute, obtains 1% azalomycin F
4% metalaxyl microemulsion.
10. bactericidal composition described in claim 1 is used to prevent the purposes of cucumber fusarium axysporum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810366664.8A CN108371186A (en) | 2018-04-23 | 2018-04-23 | Bactericidal composition containing azalomycin F and metalaxyl |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810366664.8A CN108371186A (en) | 2018-04-23 | 2018-04-23 | Bactericidal composition containing azalomycin F and metalaxyl |
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| Publication Number | Publication Date |
|---|---|
| CN108371186A true CN108371186A (en) | 2018-08-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810366664.8A Withdrawn CN108371186A (en) | 2018-04-23 | 2018-04-23 | Bactericidal composition containing azalomycin F and metalaxyl |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530096A (en) * | 2009-03-31 | 2009-09-16 | 华南农业大学 | Sterilizing composition compounded by metalaxyl and teasaponin and application thereof |
| CN101792474A (en) * | 2009-11-30 | 2010-08-04 | 中国热带农业科学院热带生物技术研究所 | Novel AzalomycinF microlide compounds and preparation method thereof and application thereof |
| CN104430399A (en) * | 2014-11-14 | 2015-03-25 | 中国农业科学院植物保护研究所 | Preparation method and application of metalaxyl and abamectin controlled-release granules |
-
2018
- 2018-04-23 CN CN201810366664.8A patent/CN108371186A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101530096A (en) * | 2009-03-31 | 2009-09-16 | 华南农业大学 | Sterilizing composition compounded by metalaxyl and teasaponin and application thereof |
| CN101792474A (en) * | 2009-11-30 | 2010-08-04 | 中国热带农业科学院热带生物技术研究所 | Novel AzalomycinF microlide compounds and preparation method thereof and application thereof |
| CN104430399A (en) * | 2014-11-14 | 2015-03-25 | 中国农业科学院植物保护研究所 | Preparation method and application of metalaxyl and abamectin controlled-release granules |
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Address after: 610000 Northwest Biochemical Company, 388 Rongtai Avenue, Cross-Strait Science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Applicant after: Zhang Yuechan Address before: 516000 Room 206, Building 1, Kechuang Center, No. 1 Huatai Road, Huinan High-tech Industrial Park, Huizhou Zhongkai High-tech Zone, Guangdong Province Applicant before: Zhang Yuechan |
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Application publication date: 20180807 |