CN108477198A - Bactericidal composition containing azalomycin F and Prochloraz - Google Patents
Bactericidal composition containing azalomycin F and Prochloraz Download PDFInfo
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- CN108477198A CN108477198A CN201810367808.1A CN201810367808A CN108477198A CN 108477198 A CN108477198 A CN 108477198A CN 201810367808 A CN201810367808 A CN 201810367808A CN 108477198 A CN108477198 A CN 108477198A
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- prochloraz
- azalomycin
- bactericidal composition
- composition according
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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Abstract
The invention discloses a kind of containing the bactericidal composition that active ingredient is azalomycin F and Prochloraz, including usual auxiliaries, azalomycin F and Prochloraz, and the quality parts ratio of azalomycin F and Prochloraz is 5:1~1:2, preferably than being 3:1~1:1.Azalomycin F and there is synergistic effect to pathogen fungi after being compounded in certain proportion with Prochloraz, is suitable for prevention by the fungus-caused crop disease of pathogen.
Description
Technical field
The invention belongs to synergetic pesticide composition fields, and in particular to one kind is fresh containing active constituent azalomycin F and miaow
The composition pesticide of amine.
Background technology
Azalomycin F (Azalomycin F), belongs to Macrocyclic lactone compounds, has broad-spectrum antifungal activity, simultaneously also
There are inhibition or killing effect, Chinese patent CN101792474B to describe azalomycin F agriculturally various agricultural pest and disease damage
Purposes, can be used for preventing banana blight and crop root knot nematode disease.
Prochloraz (Prochloraz), alias:P applied levels, Prochloraz;Chemical name:N- propyl-N- [2- (2,4,6- trichlorines
Phenoxy group) ethyl]-imidazoles -1- formamides.Prochloraz is a kind of wide-spectrum bactericide, to various crop by sac fungus and Fungi Imperfecti
Caused disease have apparent preventive effect, can also be mixed with most of fungicide, fungicide, Insecticides (tech) & Herbicides (tech), have compared with
Good control effect.There is treatment to the multiple diseases on field crop, fruit and vegetable, turf and ornamental plant and root out work
With.For broad-spectrum germicide.It is to inhibit ergosterol biosynthesis, has protection and eradicant action, to various crop ascus
Bacterium and Fungi Imperfecti disease have notable preventive effect.It can be used for preventing cereal crop stem, leaf, many diseases on fringe.
Fusarium (Fusarium) pathogen causes various plant diseases extensively.Fusorium moniliforme Sheldon (Fusarium
Moniliforme Sheld) cause bakanae disease of rice;F.graminearum schw (Fusarium graminearun Schaabe) causes small
Wheat head blight;Fusarium oxysporum (Fusarium oxysporum) causes various crop disease, as Fusarium oxysporum watermelon is specially changed
Type (Fusarium oxysporum f.sp.niveum (E.F.Smith) Snyder et Hansen) cause watermelon blight,
Fusarium oxysporum Panama specialized form (Fusarium oxysporum f.sp.cubense) causes banana blight (banana bar
By horse droop).
It is one of prevention most effective chemical means of phytopathogen using chemical agent;With the novel pesticide of not cross resistance
It is a good solution to carry out controlling plant diseases;But one novel pesticide of exploitation needs to screen a chemical combination up to ten thousand at present
Object, hundred million dollars of cost 1.2-1.5, the development cycle is 5-10, it is difficult to the speed that the upper pathogen caught up with develops immunity to drugs;It is other
Method such as crop structure adjustment, different pesticide rotations etc., in actual mechanical process, it is difficult to play apparent effect.
Develop new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research
Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.
The synergistic combination of azalomycin F and Prochloraz has not been reported, the mechanism of action and effect of azalomycin F and Prochloraz
Feature is different.
Invention content
The present invention is intended to provide a kind of Synergistic bactericidal composition containing azalomycin F and Prochloraz, is convenient for crop disease
Resistance management, health control and reduction Pesticide use amount.
The invention is realized by the following technical scheme:
The bactericidal composition containing azalomycin F and Prochloraz, active constituent be azalomycin F and Prochloraz,
The mass fraction ratio of preferred azalomycin F and Prochloraz is 5:1~1:2.
The mass fraction ratio of further preferred azalomycin F and Prochloraz is 3:1~1:1.
The mass fraction ratio of further preferred azalomycin F and Prochloraz is 3:1.
The mass fraction ratio of further preferred azalomycin F and Prochloraz is 2:1.
The mass fraction ratio of further preferred azalomycin F and Prochloraz is 1:1.
The bactericidal composition containing azalomycin F and Prochloraz removes and contains active constituent azalomycin F and Prochloraz
Outside, also contain auxiliary agent;The weight of active component is the 1%~30% of composition total weight, remaining is insecticides adjuvant.
The composition pesticide, being processed into microemulsion, water dispersible granules, granule etc., agriculturally common dosage form is just
In agriculturally using, aqueous suspension agent, aqueous emulsion, dispersible oil-suspending agent, missible oil, suspension emulsion, wettable powder can also be processed into
Other formulations of pesticide such as agent.
The granule dosage form weight percent group becomes:Azalomycin F 1~5%, Prochloraz 1~5%, dispersant
0.1~5%, wetting agent 0.1~5%, binder 0.1~5%, carrier complement to 100%.Specifically production stage is:It is specific raw
Producing step is:Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, stream is then added
Change and be granulated in bed granulating and drying machine, dry, sieve, the granule of corresponding weight percentage is made.
The dosage form of water dispersible granule weight percent group becomes:Azalomycin F 1~10%, Prochloraz 1~20%,
Dispersant 0.1~9%, disintegrant 0.1~9%, wetting agent 0.1~6%, solid carrier complements to 100%.Specific production stage
For:Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, fluid bed is then added and makes
It is granulated in grain drying machine, dries, sieves, the water dispersible granules of corresponding weight percentage are made.
The micro-emulsion form weight percent group becomes:Azalomycin F 1~10%, Prochloraz 1~20%, dispersion
Agent 0.1~10%, emulsifier 1~15%, solvent 0.1~20%, antifreezing agent 0.1~5%, deionized water complements to 100%.Tool
Body production stage is:Active ingredient and other auxiliary agents are uniformly mixed, after active ingredient and auxiliary agent dissolving, are placed in container with cutting
It cuts machine to shear 5 minutes~2 hours, obtains the microemulsion of corresponding weight percentage.
The antifreezing agent can be one or more of in glycerine, propylene glycol, diethylene glycol (DEG), urea etc..
The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur
One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..
The emulsifier can be triphenoethyl benzene phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane, castor oil
One kind in polyoxyethylene ether, fatty alcohol polyoxy ether, aliphatic acid polyethenoxy ether, isomery alcohol.
The dispersant can be APES formaldehyde condensation product, naphthalene sulfonate, benzene sulfonate, to methoxy
Base fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fat
One kind in alcohol polyoxyethylene ether, polyethylene glycol stearate, Oleate, nekal, phosphate etc.
Or it is several.
The disintegrant can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium,
Crospovidone, chitosan, sodium alginate, sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc.
One or more of.
The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon, clay,
One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..
The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine
Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin,
One or more of rosin, wood powder etc..
The solvent can be solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropanol, n-butanol, n-octyl alcohol, positive penta
Alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N-Methyl pyrrolidone, ethyl acetate, methyl oleate, phthalic acid
Dibutyl ester, sec-Butyl Acetate.
The deionized water is industrial deionized water.
It is found by experiment that, azalomycin F is used in mixed way with Prochloraz has association to Fusarium (Fusarium) pathogen
Same-action.
The present invention has the advantages that:
1, the composition pesticide provided by the invention containing active constituent azalomycin F and Prochloraz, azalomycin F and miaow
The toxicity of fresh amine Fusarium (Fusarium) pathogen within the scope of certain proportion has synergistic effect, such as Fusarium oxysporum
Watermelon specialized form (Fusarium oxysporum f.sp.niveum (E.F.Smith) Snyder et Hansen).
2, composition pesticide of the present invention has synergistic effect to target pathogen, it is possible to reduce Pesticide use amount reduces agriculture
The pollution of control of crop disease cost, mitigation to environment.
Specific implementation mode
(1), raw to survey embodiment
According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association
Same antagonism, 80 < CTC < 120 are joint action of antagonism, and CTC >=120 are synergistic function.
Survey toxicity index (ATI)=(EC of standard agent50The EC of/reagent agent50)×100.Theoretical toxicity index
In toxicity index × mixture of TTI=A medicaments in toxicity index × mixture of the percentage composition+B medicaments of A medicaments B medicaments hundred
Divide content.
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100.
Azalomycin F Prochlorazs are to Fusarium oxysporum f. sp. niveum (Fusarium oxysporum
F.sp.niveum (E.F.Smith) Snyder et Hansen) Toxicity Determination, subjects pick up from the watermelon in field
Droop pathogen Fusarium oxysporum f. sp. niveum (Fusarium oxysporum f.sp.niveum (E.F.Smith)
Snyder et Hansen) (mycelia growth method).
The Toxicity Determination result of the 1 azalomycin F Prochlorazs of table to Fusarium oxysporum f. sp. niveum.
As shown in Table 1, azalomycin F and Prochloraz mixture are 5:1~1:To Fusarium oxysporum f. sp. niveum between 2
(Fusarium oxysporum f.sp.niveum (E.F.Smith) Snyder et Hansen) has synergistic effect, altogether poison
Coefficient is 120 or more;Azalomycin F is with Prochloraz mixture 3:1~1:To Fusarium oxysporum f. sp. niveum between 1
(Fusarium oxysporum f.sp.niveum (E.F.Smith) Snyder et Hansen) makees with preferable synergy
With co-toxicity coefficient is 140 or more;And azalomycin F and Prochloraz mixture are 50:1~10:1 and 1:5~1:30 pairs
(Fusarium oxysporum f.sp.niveum (E.F.Smith) Snyder et Hansen) has no synergistic effect, altogether
Malicious coefficient is below 120.
(2), example of formulations
0.5% azalomycin F0.5% Prochloraz granules
Weigh 0.5% azalomycin F, 0.5% Prochloraz, 3% tea seed cake powder, 2% wood powder, 2% sodium carboxymethyl starch, 1%
Lignin, surplus precipitated calcium carbonate.Above-mentioned raw materials are uniformly mixed in mixed cylinder, by extruding, granulation, drying, and it is screened
0.5% azalomycin F0.5% Prochloraz granules are made in step.
3% azalomycin F3 % Prochloraz water dispersible granules
Weigh 3% azalomycin F, 3% Prochloraz, 3% lauryl sodium sulfate, 2% sodium naphthalene sulfonate, 1% chitosan,
1% sodium chloride, surplus precipitated calcium carbonate.Above-mentioned raw materials are uniformly mixed in mixed cylinder, by extruding, granulation, drying, and through sieve
3% azalomycin F3 % Prochloraz water dispersible granules are made step by step.
3% azalomycin F3 % Prochloraz microemulsions
Take 3% azalomycin F, 3% Prochloraz, 4% solvent naphtha S-150,4% glycerine, 4% aliphatic alcohol polyethenoxy
Ether, mentioned component after mixing, are added deionized water and complement to 100%, be placed in container with 7000 turns of shearing per minute
Machine is sheared 30 minutes, and 3% azalomycin F, 3% Prochloraz microemulsions are obtained.
(3), Application Example
Fusarium oxysporum (Fusarium oxysporum) causes various crop disease, such as Fusarium oxysporum f. sp. niveum
(Fusarium oxysporum f.sp.niveum (E.F.Smith) Snyder et Hansen) causes watermelon blight;Point
Fusarium oxysporum Panama specialized form (Fusarium oxysporum f.sp.cubense) causes banana blight (take by banana bar
Horse droop).
2 3% azalomycin F3 % Prochloraz microemulsions of table prevent the watermelon blight test of pesticide effectiveness
2 data result of table shows 1% azalomycin F4 % Prochloraz microemulsions dosage, 10 mg/kg (active ingredient)
250 milliliter/plant pouring roots are outstanding to watermelon blight control effect, 10 days after medicine, 20 days control effects 80% or more, and it is excellent
In 16% hymexazo, 40% thiophanate-methyl wettable powder (purchased in market, PD20170290, Chengdu Kelilong Biochemical Co., Ltd.'s life
Production) 900 mg/kgs (active ingredient), 250 milliliters/plant.
Claims (10)
1. a kind of bactericidal composition containing azalomycin F and Prochloraz, it is characterised in that:Effective ingredient be azalomycin F and
The mass fraction ratio of Prochloraz, azalomycin F and Prochloraz is 5:1~1:2.
2. bactericidal composition according to claim 1, it is characterised in that:The quality parts ratio of azalomycin F and Prochloraz
Example is 3:1~1:1.
3. bactericidal composition according to claim 1, it is characterised in that:The quality parts ratio of azalomycin F and Prochloraz
Example is 3:1.
4. bactericidal composition according to claim 1, it is characterised in that:The quality parts ratio of azalomycin F and Prochloraz
Example is 2:1.
5. bactericidal composition according to claim 1, it is characterised in that:The quality parts ratio of azalomycin F and Prochloraz
Example is 1:1.
6. bactericidal composition according to claim 1, it is characterised in that:The weight of active component is composition total weight
1%~30%, remaining is insecticides adjuvant.
7. bactericidal composition according to claim 1, it is characterised in that:The weight of active component is composition total weight
5%~15%, remaining is insecticides adjuvant.
8. bactericidal composition according to claim 1, it is characterised in that:The dosage form of the composition is granule, moisture
One kind in shot agent, microemulsion.
9. a kind of bactericidal composition containing azalomycin F and Prochloraz, it is characterised in that weight percent:Take 3% Ah Zhas mould
Plain F, 3% Prochloraz, 4% solvent naphtha S-150,4% glycerine, 4% fatty alcohol polyoxyethylene ether, mentioned component are uniformly mixed
Afterwards, deionized water is added and complements to 100%, be placed in container and sheared 30 minutes with 7000 turns of cutter per minute, obtained
3% azalomycin F, 3% Prochloraz microemulsions.
10. bactericidal composition described in claim 1 is used to prevent the purposes of watermelon blight.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101263822A (en) * | 2007-11-25 | 2008-09-17 | 江苏辉丰农化股份有限公司 | Bactericidal composition for preventing and treating rice blast |
CN101792474A (en) * | 2009-11-30 | 2010-08-04 | 中国热带农业科学院热带生物技术研究所 | Novel AzalomycinF microlide compounds and preparation method thereof and application thereof |
CN102113504A (en) * | 2010-01-05 | 2011-07-06 | 海南正业中农高科股份有限公司 | Sterilization composite containing polyoxin and prochloraz |
-
2018
- 2018-04-23 CN CN201810367808.1A patent/CN108477198A/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101263822A (en) * | 2007-11-25 | 2008-09-17 | 江苏辉丰农化股份有限公司 | Bactericidal composition for preventing and treating rice blast |
CN101792474A (en) * | 2009-11-30 | 2010-08-04 | 中国热带农业科学院热带生物技术研究所 | Novel AzalomycinF microlide compounds and preparation method thereof and application thereof |
CN102113504A (en) * | 2010-01-05 | 2011-07-06 | 海南正业中农高科股份有限公司 | Sterilization composite containing polyoxin and prochloraz |
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Address after: 610000 Northwest Biochemical Company, 388 Rongtai Avenue, Cross-Strait Science and Technology Industrial Development Park, Wenjiang District, Chengdu City, Sichuan Province Applicant after: Wen Miaoyun Address before: 516000 Wuyi Village, Chenjiang Street, Zhongkai High-tech Zone, Huizhou City, Guangdong Province Applicant before: Wen Miaoyun |
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Application publication date: 20180904 |