CN108617648A - Bactericidal composition containing octyl trichlamide and carvacrol - Google Patents
Bactericidal composition containing octyl trichlamide and carvacrol Download PDFInfo
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- CN108617648A CN108617648A CN201810335038.2A CN201810335038A CN108617648A CN 108617648 A CN108617648 A CN 108617648A CN 201810335038 A CN201810335038 A CN 201810335038A CN 108617648 A CN108617648 A CN 108617648A
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- Prior art keywords
- carvacrol
- octyl trichlamide
- bactericidal composition
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- mass fraction
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/04—Nitrogen directly attached to aliphatic or cycloaliphatic carbon atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of containing the bactericidal composition that active ingredient is octyl trichlamide and carvacrol, including usual auxiliaries, octyl trichlamide and carvacrol, and the quality parts ratio of octyl trichlamide and carvacrol is 20:1~5:1, preferably than being 15:1~12:1.Octyl trichlamide and there is synergistic effect to pathogen fungi and crop root increase after being compounded in certain proportion with carvacrol, is suitable for prevention by the fungus-caused crop disease of pathogen and enhancing crop root.
Description
Technical field
The invention belongs to synergetic pesticide composition fields, and in particular to a kind of containing active constituent octyl trichlamide and carvacrol
Composition pesticide.
Technical background
Octyl trichlamide, english common name bromothalonil, chemical formula C6H6Br2N2, chemical name 1,2'- bis- bromo- 2,
4- dicyanobutanes.Octyl trichlamide is a kind of wide spectrum, low toxicity, mould proof, algae-killing bactericidal agent.It can inhibit and root out bacterium, fungi and algae
The growth of class has preferable control effect to corps diseases, especially has special efficacy to anthracnose.
Carvacrol, english common name carvacrol, chemical name：Carvacrol.Carvacrol is plant
Extract has preferable preventive effect to the crop gray mold caused by Botrytis pathogen, to other pathogen fungi such as anthraxs
Bacterium etc. also has preferable activity, environmentally friendly.
It is one of prevention most effective chemical means of phytopathogen using chemical agent；With the novel pesticide of not cross resistance
It is a good solution to carry out controlling plant diseases；But one novel pesticide of exploitation needs to screen a chemical combination up to ten thousand at present
Object, hundred million dollars of cost 1.2-1.5, the development cycle is 5-10, it is difficult to the speed that the upper pathogen caught up with develops immunity to drugs；It is other
Method such as crop structure adjustment, different pesticide rotations etc., in actual mechanical process, it is difficult to play apparent effect.
Develop new product fungicide is expensive, the period is long, and in contrast, exploitation is efficient, less toxic, low-residual with research
Compounding have with mixture invest small, lead time it is short and by attention both domestic and external, it is numerous and confused to increase development dynamics.
Octyl trichlamide and the synergistic combination of carvacrol have not been reported, and the mechanism of action and action character of octyl trichlamide and carvacrol are not
Together.
Invention content
The present invention is intended to provide a kind of Synergistic bactericidal composition containing octyl trichlamide and carvacrol, is convenient for crop disease resistance
Management, health control and reduction Pesticide use amount.
The invention is realized by the following technical scheme：
The bactericidal composition containing octyl trichlamide and carvacrol, active constituent be octyl trichlamide and carvacrol, preferably
Octyl trichlamide and the mass fraction ratio of carvacrol are 20:1~5:1.
The mass fraction ratio of further preferred octyl trichlamide and carvacrol is 15:1~12:1.
The mass fraction ratio of further preferred octyl trichlamide and carvacrol is 15:1.
The mass fraction ratio of further preferred octyl trichlamide and carvacrol is 14:1.
The mass fraction ratio of further preferred octyl trichlamide and carvacrol is 13:1.
The mass fraction ratio of further preferred octyl trichlamide and carvacrol is 12:1.
The bactericidal composition containing octyl trichlamide and carvacrol, in addition to containing active constituent octyl trichlamide and carvacrol, also
Contain auxiliary agent；The weight of active component is the 0.1%~30% of composition total weight, remaining is insecticides adjuvant.
The composition pesticide, being processed into microemulsion, water dispersible granules, granule etc., agriculturally common dosage form is just
In agriculturally using, aqueous suspension agent, aqueous emulsion, dispersible oil-suspending agent, missible oil, suspension emulsion, wettable powder can also be processed into
Other formulations of pesticide such as agent.
The granule dosage form weight percent group becomes：Octyl trichlamide 0.1~5%, carvacrol 0.01~1%, dispersion
Agent 0.1~7%, wetting agent 0.1~7%, binder 0.1~5%, carrier complement to 100%.Specifically production stage is：Specifically
Production stage is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, is then added
It is granulated, dried, sieved in fluidized-bed granulation dryer, the granule of corresponding weight percentage is made.
The dosage form of water dispersible granule weight percent group becomes：Octyl trichlamide 0.1~5%, carvacrol 0.01~5%,
Dispersant 0.1~15%, disintegrant 0.1~15%, wetting agent 0.1~5%, solid carrier complements to 100%.Specific production step
Suddenly it is：Active ingredient and other auxiliary agents are uniformly mixed, crushed with micro jet, through mediating, fluid bed is then added
It is granulated, dried, sieved in granulating and drying machine, the water dispersible granules of corresponding weight percentage are made.
The micro-emulsion form weight percent group becomes：Octyl trichlamide 0.1~20%, carvacrol 0.01~10% divide
Powder 0.1~153%, emulsifier 1~10%, solvent 0.1~30%, antifreezing agent 0.1~5%, deionized water complements to
100%.Specifically production stage is：Active ingredient and other auxiliary agents are uniformly mixed, after active ingredient and auxiliary agent dissolving, are placed in appearance
It is sheared -2 hours 5 minutes with cutter in device, obtains the microemulsion of corresponding weight percentage.
The antifreezing agent can be one or more of in glycerine, propylene glycol, diethylene glycol (DEG), urea etc..
The wetting agent can be lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, alkyl sulphur
One or more of sour sodium, tea seed cake powder, spaonin powder, spaonin powder, wheat bran, sorghum starch, buckwheat etc..
The emulsifier can be agriculture breast 33#, agriculture breast 34#, agriculture breast 500#, agriculture breast 600#, Nongru-700 #, agriculture breast 1601#,
Agriculture breast 1602#, T60, S80, TX-10, OP-10, NP-10, Nonyl pheno (EO=10) ether phosphate, triphenoethyl benzene
One kind in phenol polyethenoxy ether phosphate, BBM-3, epoxychloropropane.
The dispersant can be APES formaldehyde condensation product, naphthalenesulfonate formaldehyde condensation compound, to first
Oxygroup fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, alkyl phenol polyoxyethylene ether sulfate, alkyl benzene sulphonate
Calcium salt, aliphatic ester sulfate, alkyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, polyethylene glycol stearate, sorbose
One or more of alcohol oleate, nekal etc..
The disintegrant can be sodium carboxymethyl starch, low-substituted hydroxypropyl cellulose, croscarmellose sodium,
Crospovidone, chitosan, sodium alginate sodium bicarbonate, magnesium chloride, aluminium chloride, sodium chloride, urea, ammonium sulfate, bentonite etc.
One or more of.
The solid carrier can be precipitated calcium carbonate, clay, kaolin, diatomite, bentonite, white carbon, clay,
One or more of attapulgite, talcum powder, quartz sand, wood powder, walnut parting, lignin, wheat bran, rice chaff, sawdust etc..
The binder can be sucrose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose, polyvinylpyrrolidine
Ketone, calcium carboxymethylcellulose, carboxy-propyl cellulose, dextrin, amylodextrin, polyvinylpyrrolidone, sticky kaolin, paraffin,
One or more of rosin, wood powder etc..
The solvent can be toluene, dimethylbenzene, trimethylbenzene, solvent naphtha S-150, solvent naphtha S-200, ethyl alcohol, isopropanol,
N-butanol, n-octyl alcohol, n-amyl alcohol, acetone, cyclohexanone, hexane, dimethylformamide, N-Methyl pyrrolidone, acetonitrile, dichloromethane
Alkane, ethyl acetate, methyl oleate, dibutyl phthalate, sec-Butyl Acetate.
The deionized water is industrial deionized water.
It is found by experiment that, octyl trichlamide is used in mixed way with carvacrol to Sphaerotheca (Sphaerotheca), Bu Shi white powder
Pseudomonas (Blumiria), Erysiphe (Erysiphe), Gibberella (Gibberella), Sclerotinia (Sclerotinia), Portugal
Grape Sclerotinia (Botryotinia), Puccinia (Puccinia), Tilletia (Tilletia), glue Rust
(Gymnosporzngium), Phakopsora (Phakopsora), Ustilago (Ustilago), pyrenomycetes category
(Rhizoctonia), Verticillium (Verticillium), Alternaria (Alternaria), Pyricularia Sacc. (Pyriculara),
Botrytis (Botrytis), Cercospora (Cercospora), Fusarium (Fusarium), colletotrichum
(Colletotrichum) etc. there is synergistic effect.
The present invention has the advantages that：
1, the composition pesticide provided by the invention containing active constituent octyl trichlamide and carvacrol, octyl trichlamide exist with carvacrol
There is synergistic effect to the toxicity of target pathogen within the scope of certain proportion, such as strawberry anthrax-bacilus (Colletotrichum
fragariae Brooks)。
2, composition pesticide of the present invention has synergistic effect to target pathogen, it is possible to reduce Pesticide use amount reduces agriculture
The pollution of control of crop disease cost, mitigation to environment.
3, present composition active constituent octyl trichlamide and carvacrol increase strawberry root system total amount within the scope of certain proportion
Add with synergistic effect.
Specific implementation mode
(1), raw to survey embodiment
According to Sun Yunpei's Method, the synergistic effect of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), i.e. CTC≤80 are association
Same antagonism, 80 ＜ CTC ＜ 120 are joint action of antagonism, and CTC >=120 are synergistic function.Survey toxicity index
(ATI)=(EC of standard agent50The EC of/reagent agent50)×100；The toxicity index of theoretical toxicity index TTI=A medicaments ×
In mixture in toxicity index × mixture of the percentage composition+B medicaments of A medicaments B medicaments percentage composition；Co-toxicity coefficient (CTC)=
[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI)] × 100
Embodiment one：Octyl trichlamide carvacrol is to strawberry anthrax-bacilus (Colletotrichum fragariae Brooks)
Toxicity Determination, subjects pick up from the pathogen strawberry anthrax-bacilus (Colletotrichum of the Strawberry anthracnose in field
fragariae Brooks)。
Table 1：Interior of the octyl trichlamide carvacrol to strawberry anthrax-bacilus (Colletotrichum fragariae Brooks)
Toxicity test result (mycelia growth method).
As shown in Table 1, octyl trichlamide and carvacrol mixture are 20:1~5:Between 1, to strawberry anthrax-bacilus
(Colletotrichum fragariae Brooks) has synergistic effect, and co-toxicity coefficient is 120 or more；Octyl trichlamide and perfume
Celery phenol mixture is 15:1~12:There is synergy to strawberry anthrax-bacilus (Colletotrichum fragariae Brooks) between 1
Effect, co-toxicity coefficient is 160 or more；And octyl trichlamide and carvacrol mixture are 50:1~30:1 and 1:1~30 pair of strawberry anthrax
Bacterium (Colletotrichum fragariae Brooks) co-toxicity coefficient is 120 hereinafter, without synergistic effect.
Three octyl trichlamide of embodiment influences to test with carvacrol on strawberry root system
Colby equatioies are used to determine desired effect (Colby, the S.R.Weeds 1967,15,20- of mixture
22.Calculation of the synergistic and antagonistic response of herbicide
combinations)：
Following equatioies are used to calculate the desired value of the mixture containing two kinds of active components A and B：
In formula：
The effect of active components A of identical (dosage) concentration used in the mixture that A=is observed；
The effect of active constituent B of identical (dosage) concentration used in the mixture that B=is observed.
The active actual observation value (E) of the concentration (dosage) used in the mixture is more than desired value (E0) when, mixture is shown as
There is unexpected synergistic effect to target.
Test (the stem of 2 octyl trichlamide of table and the carvacrol mixing Herba Hyperici elodeoidis certain kind of berries (milk strawberry) root system total amount (dry weight) increment rate
Foliar spray mist, every plant of spray amount is 2 milliliters, is tested within 30 days after medicine)
The data result that table 2 is recorded shows that octyl trichlamide administration dosage (cauline leaf spraying) is 2 milliliters of 140 mg/kg and perfume
Celery phenol administration dosage (cauline leaf spraying) is that root system of 2 milliliters of 10 mg/kg to strawberry (milk strawberry) increases with collaboration work
With the weight of root system increment rate that mixture observes is more than desired weight of root system increment rate 8.3%.
(2), example of formulations
1.4% octyl trichlamide, 0.1% carvacrol granule
Weigh 1.4% octyl trichlamide, 0.1% carvacrol, 2% wood powder, 1% corn flour, 4% rice chaff, diatomite.Above-mentioned raw materials
It is uniformly mixed in mixed cylinder, by extruding, granulation, drying, and 1.4% octyl trichlamide, 0.1% Sheep's-parsley is made in screened step
Phenol granule.
12% octyl trichlamide, 1% carvacrol micro-emulsion
14% octyl trichlamide, 1% carvacrol, 5% ethyl acetate, 3% glycerine, 8% castor oil polyoxyethylene ether are taken, it is above-mentioned
Ingredient is first added deionized water and complements to 100% after mixing, is placed in container and is sheared with 6000 turns of cutter per minute
20 minutes, obtain 14% octyl trichlamide, 1% carvacrol micro-emulsion.
(3), Application Example
3 12% octyl trichlamide of table, 1% carvacrol micro-emulsion prevents the Strawberry anthracnose test of pesticide effectiveness (greenhouse, cauline leaf spraying)
Claims (10)
1. the bactericidal composition containing octyl trichlamide and carvacrol, it is characterised in that：Effective ingredient is octyl trichlamide and carvacrol, pungent bacterium
The mass fraction ratio of amine and carvacrol is 20:1~5:1.
2. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of octyl trichlamide and carvacrol
For：15:1~12:1.
3. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of octyl trichlamide and carvacrol
For：15:1.
4. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of octyl trichlamide and carvacrol
For：14:1.
5. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of octyl trichlamide and carvacrol
For：13:1.
6. bactericidal composition according to claim 1, it is characterised in that：The mass fraction ratio of octyl trichlamide and carvacrol
For：12:1.
7. bactericidal composition according to claim 1, the weight of active component is the 0.1%~30% of composition total weight,
Remaining is insecticides adjuvant.
8. bactericidal composition according to claim 1, it is characterised in that：The dosage form of the composition is granule, moisture
One kind in shot agent, microemulsion.
9. the bactericidal composition described in claim 4, microemulsion preparation method is as follows：Take 14% octyl trichlamide, 1% carvacrol, 5%
Ethyl acetate, 3% glycerine, 8% castor oil polyoxyethylene ether, mentioned component are first added deionized water and complement to after mixing
100%, it is placed in container and is sheared 20 minutes with 6000 turns of cutter per minute, obtain 14% octyl trichlamide, 1% carvacrol micro emulsion
Agent.
10. the bactericidal composition described in claim 1 to 9 any one is total for preventing Strawberry anthracnose, increase strawberry root system
The purposes of amount.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810335038.2A CN108617648A (en) | 2018-04-15 | 2018-04-15 | Bactericidal composition containing octyl trichlamide and carvacrol |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810335038.2A CN108617648A (en) | 2018-04-15 | 2018-04-15 | Bactericidal composition containing octyl trichlamide and carvacrol |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308817A (en) * | 2011-07-27 | 2012-01-11 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition |
| CN103098796A (en) * | 2012-12-30 | 2013-05-15 | 湖南农大海特农化有限公司 | Bactericidal composition of zinc bacteria amine and fluazinam |
| CN103651452A (en) * | 2012-09-11 | 2014-03-26 | 青岛星牌作物科学有限公司 | Bactericidal composition containing octyl trichlamide and carbendazim and application of bactericidal composition |
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2018
- 2018-04-15 CN CN201810335038.2A patent/CN108617648A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102308817A (en) * | 2011-07-27 | 2012-01-11 | 青岛奥迪斯生物科技有限公司 | Bactericidal composition |
| CN103651452A (en) * | 2012-09-11 | 2014-03-26 | 青岛星牌作物科学有限公司 | Bactericidal composition containing octyl trichlamide and carbendazim and application of bactericidal composition |
| CN103098796A (en) * | 2012-12-30 | 2013-05-15 | 湖南农大海特农化有限公司 | Bactericidal composition of zinc bacteria amine and fluazinam |
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