CN108567803B - Preparation method of Jinshuibaojin capsules - Google Patents
Preparation method of Jinshuibaojin capsules Download PDFInfo
- Publication number
- CN108567803B CN108567803B CN201810693394.1A CN201810693394A CN108567803B CN 108567803 B CN108567803 B CN 108567803B CN 201810693394 A CN201810693394 A CN 201810693394A CN 108567803 B CN108567803 B CN 108567803B
- Authority
- CN
- China
- Prior art keywords
- powder
- tween
- taking
- preparation
- fermented cordyceps
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a preparation method of Jinshuibaojin capsules, which are prepared from the following raw and auxiliary materials: 400g of fermented cordyceps sinensis (Cs-4), and American ginseng: 97g, magnesium stearate: 3g, Tween-80: 2.5-7.5g, the preparation method comprises the following steps: taking fermented cordyceps sinensis (Cs-4), crushing, and screening by a 40-mesh screen; taking American ginseng, crushing, and screening with a 40-mesh screen; standby; mixing fermented Cordyceps powder (Cs-4) and radix Panacis Quinquefolii powder, adding Tween-80 and water 800g, grinding with colloid mill for 10-30min, drying, granulating, and filling into empty capsule.
Description
Technical Field
The invention belongs to the field of pharmacy, and particularly relates to a preparation method of Jinshuibaojin capsules.
Background
The Jinshuibaojin capsule is prepared by taking paecilomyces hepiali mycelium (fermented cordyceps sinensis powder Cs-4) and American ginseng as main raw materials.
Wherein the fermented Cordyceps powder is prepared by extracting authentic Cordyceps strain (Cs-4) from fresh and natural Cordyceps produced in Qinghai, and performing submerged fermentation culture to obtain Cordyceps mycelium. The fermented cordyceps sinensis powder (Cs-4) is derived from cordyceps sinensis, the effective components and the efficacy of the fermented cordyceps sinensis powder are similar to those of natural cordyceps sinensis, the medical record of cordyceps sinensis is recorded in Tibetan herbal for over 1000 years, and the cordyceps sinensis is sweet in taste, has mild nature, enters the kidney and lung meridians, protects the lung and tonifies the kidney, supplements the essence, stops bleeding and reduces phlegm, has cough caused by fatigue and treats diaphragm diseases. Tonifying lung and kidney, and replenishing essence and qi, and can be used for treating deficiency of lung and kidney, deficiency of vital essence, chronic cough, asthma, listlessness, insomnia, amnesia, soreness of waist and knees, menoxenia, etc. The American ginseng is matched with the traditional Chinese medicine for tonifying qi and nourishing yin, clearing fire and promoting the production of body fluid, the traditional Chinese medicine is sweet in taste and warm in nature and mild in medicine property, enters the lung and kidney meridians and is tonifying but not severe, and the two medicines are combined and supplement each other.
The Jinshuibaojin capsule has the effects of resisting fatigue, promoting metabolism, enhancing immunity, delaying senility, resisting anoxia, resisting high temperature and cold, can adjust in-vivo metabolic disorder caused by long-time fatigue, and is a good product for conditioning human body functions.
At present, no patents related to the preparation method of the Jinshuibaojin capsule disclosed by Chinese patents exist, but the Jinshuibaojin capsule prepared by the prior art only contains fermented cordyceps sinensis powder, American ginseng and magnesium stearate, and the medicinal components are combined too tightly, so that the content of the capsule is slowly disintegrated and released, and the absorption of the medicament in the body is influenced.
Colloid mills are machines for the fine processing of fluid materials. It integrates various performances of machines such as a homogenizer, a ball mill, a three-roller machine, a shearing machine, a stirring machine and the like, and has excellent effects of ultramicro crushing, dispersing and emulsifying, homogenizing, mixing and the like. After the material is processed, the granularity reaches 2-50 microns, the homogeneity degree reaches more than 90 percent, and the material is an ultramicron processing device. The superfine grinding powder is suitable for superfine grinding of wet materials in pharmacy, food, chemical industry and other industries, and can be used for grinding, emulsifying, homogenizing and mixing various semi-wet bodies and emulsion substances.
The invention optimizes and screens the existing prescription and preparation method, and introduces a colloid mill grinding technology, and the unexpected discovery shows that the Jinshuibaojin capsule prepared by the method of the invention effectively improves the release and bioavailability.
Disclosure of Invention
The invention aims to provide a preparation method of Jinshuibaojin capsules.
The capsule prepared by the method can effectively improve the curative effect of the product.
The preparation method comprises the following steps:
prescription:
fermented Cordyceps sinensis (Cs-4) powder 400g
American ginseng: 97g
Magnesium stearate: 3g
Tween-80: 2.5-7.5g
The preparation method comprises the following steps:
taking fermented cordyceps sinensis powder (Cs-4) according to the prescription amount, crushing, and sieving with a 40-mesh sieve; taking American ginseng of the prescription amount, crushing and sieving by a 40-mesh sieve; standby; taking fermented Cordyceps powder (Cs-4) powder and radix Panacis Quinquefolii powder, adding tween-80 and purified water 800g, grinding with colloid mill for 10-30min, drying, grading, adding magnesium stearate, mixing for 30min, drying, and filling.
The preparation method is obtained by screening, and the screening process is as follows:
experiment one, wetting agent: screening of Tween-80 dosage
The preparation method comprises the following steps: taking fermented cordyceps sinensis powder (Cs-4) according to the prescription amount, crushing, and sieving with a 40-mesh sieve; taking American ginseng of the prescription amount, crushing and sieving by a 40-mesh sieve; standby; taking fermented Cordyceps powder (Cs-4) powder and radix Panacis Quinquefolii powder, adding appropriate amount of Tween-80 and purified water 800g, grinding with colloid mill for 10-30min, drying, grading, adding magnesium stearate, mixing for 30min, drying, and filling. Lot number 170301.
170301 adenosine content 250.6mg/100g was determined. Different dosages of tween-80 are added into the prescription, the dissolution rate of the adenosine is taken as an in vitro evaluation index, the optimal dosage of the tween-80 is screened, and the dissolution rate is compared with the prescription without the tween-80.
The detection method comprises the following steps: taking the sampling time (0min, 5min, 10min, 15min, 20min, 30min) as the abscissa and the adenosine dissolution rate as the ordinate, drawing the dissolution curve.
TABLE 1 screening of Tween-80 amounts
| Amount of Tween-80 | 0g | 2.5g | 5.0g | 7.5g |
| Preparation of the total amount | 500g | 500g | 500g | 500g |
When the amount of tween-80 was 0g, the results of measuring the adenosine content at each time (see table 2) and the dissolution curve (see fig. 1) were as follows:
TABLE 2 adenosine content at each time point (amount of Tween-80: 2.5g)
When the amount of tween-80 was 2.5g, the results of measuring the adenosine content at each time (see table 3) and the dissolution curve (see fig. 2) were as follows:
TABLE 3 adenosine content at each time point (Tween-80 amount: 2.5g)
When the amount of Tween-80 was 5.0g, the results of determination of adenosine content at each time (see Table 4) and dissolution profile (see FIG. 3) were as follows:
TABLE 4 adenosine content at each time point (Tween-80 amount: 5.0g)
When the amount of tween-80 was 7.5g, the results of measuring the adenosine content at each time (see table 5) and the dissolution profile (see fig. 4) were as follows:
TABLE 5 adenosine content at each time point (Tween-80 amount: 7.5g)
The dissolution rate of adenosine at 5min is taken as an evaluation index, and the result summary shows that:
TABLE 6 screening results for Tween-80 dosage
The results show that: after the tween-80 is added, the dissolution rate of the adenosine is obviously superior to that of the adenosine in the prescription which is not added, when the dosage of the tween-80 is not less than 5.0g, the dissolution rate of the adenosine in 5min is more than 85 percent, and the dissolution rate does not increase along with the increase of the tween-80.
Experiment two, colloid mill grinding time screening
The preparation method comprises the following steps: taking fermented cordyceps sinensis powder (Cs-4) according to the prescription amount, crushing, and sieving with a 40-mesh sieve; taking American ginseng of the prescription amount, crushing and sieving by a 40-mesh sieve; standby; taking fermented Cordyceps powder (Cs-4) powder and radix Panacis Quinquefolii powder, adding tween-80 and purified water 800g, grinding with colloid mill for 10-30min, drying, grading, adding magnesium stearate, mixing for 30min, drying, and filling.
Detecting an object: taking four batches of capsules prepared by grinding for 10min, 15min, 20min, 25min and 30min by a colloid mill and one batch of capsules not ground by the colloid mill, dissolving out under the same condition, and sampling to determine the adenosine dissolution rate when dissolving out for 5 min.
The experimental results are as follows:
the results show that: the grinding time reaches 20min, and almost all dissolution rate is achieved.
Through the above experiment, the optimum dosage of Tween-80 and colloid mill grinding time are determined.
The advantages of the invention compared with the prior art are as follows
Drawings
FIG. 1: when the dosage of tween-80 is 0g, the prepared Jinshuibaojin capsule takes the sampling time (0min, 5min, 10min, 15min, 20min and 30min) as the abscissa and the dissolution rate of adenosine as the dissolution curve plotted on the ordinate.
FIG. 2: when the dosage of tween-80 is 2.5g, the prepared Jinshuibaojin capsule takes the sampling time (0min, 5min, 10min, 15min, 20min and 30min) as the abscissa and the adenosine dissolution rate as the dissolution curve plotted on the ordinate.
FIG. 3: when the dosage of tween-80 is 5.0g, the prepared Jinshuibaojin capsule takes the sampling time (0min, 5min, 10min, 15min, 20min, 30min) as the abscissa and the adenosine dissolution rate as the dissolution curve plotted on the ordinate.
FIG. 4: when the dosage of tween-80 is 7.5g, the prepared Jinshuibaojin capsule takes the sampling time (0min, 5min, 10min, 15min, 20min and 30min) as the abscissa and the adenosine dissolution rate as the dissolution curve plotted on the ordinate.
Detailed Description
The invention is further illustrated by the following examples.
Example 1
Fermented Cordyceps sinensis (Cs-4) powder 400g
American ginseng: 97g
Magnesium stearate: 3g
Tween-80: 5.0g
The preparation method comprises the following steps:
taking fermented cordyceps sinensis powder (Cs-4) according to the prescription amount, crushing, and sieving with a 40-mesh sieve; taking American ginseng of the prescription amount, crushing and sieving by a 40-mesh sieve; standby; taking fermented Cordyceps powder (Cs-4) powder and radix Panacis Quinquefolii powder, adding tween-80 and purified water 800g, grinding with colloid mill for 20min, drying, grading, adding magnesium stearate, mixing for 30min, drying, and filling.
Example 2:
the prescription process is as follows:
fermented Cordyceps sinensis (Cs-4) powder 400g
American ginseng: 97g
Magnesium stearate: 3g
Tween-80: 2.5g
The preparation method comprises the following steps:
taking fermented cordyceps sinensis powder (Cs-4) according to the prescription amount, crushing, and sieving with a 40-mesh sieve; taking American ginseng of the prescription amount, crushing and sieving by a 40-mesh sieve; standby; taking fermented Cordyceps powder (Cs-4) powder and radix Panacis Quinquefolii powder, adding tween-80 and purified water 800g, grinding with colloid mill for 10min, drying, grading, adding magnesium stearate, mixing for 30min, drying, and filling.
Example 3:
the prescription process is as follows:
fermented Cordyceps sinensis (Cs-4) powder 400g
American ginseng: 97g
Magnesium stearate: 3g
Tween-80: 7.5g
The preparation method comprises the following steps:
taking fermented cordyceps sinensis powder (Cs-4) according to the prescription amount, crushing, and sieving with a 40-mesh sieve; taking American ginseng of the prescription amount, crushing and sieving by a 40-mesh sieve; standby; taking fermented Cordyceps powder (Cs-4) powder and radix Panacis Quinquefolii powder, adding tween-80 and purified water 800g, grinding with colloid mill for 20min, drying, grading, adding magnesium stearate, mixing for 30min, drying, and filling.
Example 4:
the prescription process is as follows:
fermented Cordyceps sinensis (Cs-4) powder 400g
American ginseng: 97g
Magnesium stearate: 3g
Tween-80: 5.0g
The preparation method comprises the following steps:
taking fermented cordyceps sinensis powder (Cs-4) according to the prescription amount, crushing, and sieving with a 40-mesh sieve; taking American ginseng of the prescription amount, crushing and sieving by a 40-mesh sieve; standby; taking fermented Cordyceps powder (Cs-4) powder and radix Panacis Quinquefolii powder, adding tween-80 and purified water 800g, grinding with colloid mill for 25min, drying, grading, adding magnesium stearate, mixing for 30min, drying, and filling.
Claims (1)
1. The preparation method of the Jinshuibaojin capsule is characterized in that the Jinshuibaojin capsule is prepared from the following raw and auxiliary materials:
prescription
C, fermentation cordyceps sinensis powder Cs-4: 400g
American ginseng: 97g
Magnesium stearate: 3g
Tween-80: 5.0g
Taking fermented cordyceps sinensis powder Cs-4, crushing, and screening by using a 40-mesh screen; taking American ginseng, crushing, and screening with a 40-mesh screen; standby; taking fermented Cordyceps powder Cs-4 powder and radix Panacis Quinquefolii powder, adding tween-80 and purified water 800g, grinding with colloid mill for 20min, drying, grading, adding magnesium stearate, mixing for 30min, drying, and filling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810693394.1A CN108567803B (en) | 2018-06-29 | 2018-06-29 | Preparation method of Jinshuibaojin capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810693394.1A CN108567803B (en) | 2018-06-29 | 2018-06-29 | Preparation method of Jinshuibaojin capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108567803A CN108567803A (en) | 2018-09-25 |
| CN108567803B true CN108567803B (en) | 2021-03-02 |
Family
ID=63572358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810693394.1A Active CN108567803B (en) | 2018-06-29 | 2018-06-29 | Preparation method of Jinshuibaojin capsules |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108567803B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640488A (en) * | 2004-01-09 | 2005-07-20 | 蒋朝宗 | Method for preparing supermicro powder preparation of cordyceps sinensis mycelium |
| CN1887300A (en) * | 2005-06-27 | 2007-01-03 | 仁和（集团）发展有限公司 | Chinese medicine composition and its prepn process and quality control method |
| CN102335212A (en) * | 2011-09-26 | 2012-02-01 | 江西济民可信集团有限公司 | Chinese medicine Jinshuibao golden pill preparation and preparation method thereof |
| CN102365098A (en) * | 2009-01-30 | 2012-02-29 | 明治制果药业株式会社 | Finely pulverized pharmaceutical composition |
| CN102488673A (en) * | 2011-12-06 | 2012-06-13 | 沈阳药科大学 | Probucol nanometer dispersion and preparation method thereof |
-
2018
- 2018-06-29 CN CN201810693394.1A patent/CN108567803B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640488A (en) * | 2004-01-09 | 2005-07-20 | 蒋朝宗 | Method for preparing supermicro powder preparation of cordyceps sinensis mycelium |
| CN1887300A (en) * | 2005-06-27 | 2007-01-03 | 仁和（集团）发展有限公司 | Chinese medicine composition and its prepn process and quality control method |
| CN102365098A (en) * | 2009-01-30 | 2012-02-29 | 明治制果药业株式会社 | Finely pulverized pharmaceutical composition |
| CN102335212A (en) * | 2011-09-26 | 2012-02-01 | 江西济民可信集团有限公司 | Chinese medicine Jinshuibao golden pill preparation and preparation method thereof |
| CN102488673A (en) * | 2011-12-06 | 2012-06-13 | 沈阳药科大学 | Probucol nanometer dispersion and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108567803A (en) | 2018-09-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102406679B (en) | Traditional Chinese medicine American ginseng buccal tablet | |
| CN102727534B (en) | Ultrafine traditional Chinese medicinal granule piece and preparation process thereof | |
| CN102284020A (en) | Composite with actions of relieving alcoholism and protecting liver and preparation method and applications thereof | |
| CN104055871A (en) | Traditional Chinese medicinal composition for improving sleeping quality and application of traditional Chinese medicinal composition | |
| CN104585743B (en) | A kind of Herba Cistanches effervescent tablet and its preparation process | |
| CN102406690A (en) | Traditional Chinese medicine gynostemma pentaphylla buccal tablet | |
| CN108785412B (en) | Composition with function of improving sleep and preparation method thereof | |
| CN108567803B (en) | Preparation method of Jinshuibaojin capsules | |
| CN104547616B (en) | A kind of Chinese medicinal tablet and preparation method thereof | |
| CN105055569A (en) | Anti-tumor shark fin bone meal Chinese herbal medicine health oral liquid capable of improving immunity and preparation method thereof | |
| CN105055707A (en) | Lipid-lowering Chinese herbal medicinal health oral liquid containing shark cartilage powder and preparation method of oral liquid | |
| CN107982286A (en) | A kind of cordyceps sinensis lozenge and preparation method thereof | |
| CN110772552A (en) | Ginseng tablet capable of improving immunity and preparation method thereof | |
| CN102188544B (en) | Composition for preventing and curing pneumoconiosis and preparation method thereof | |
| CN103584092A (en) | Health-care composition | |
| CN101032524B (en) | Application of martianus dermestoides in producing oxygen-deficient resisting medicine or healthy food | |
| CN104800332B (en) | Menstruation-regulating face-beautifying piece and preparation method thereof | |
| CN113599471A (en) | Traditional Chinese medicine granules for primary lung cancer and production process thereof | |
| CN104857180A (en) | Anti-fatigue and immunity-improving composition as well as preparation method and application thereof | |
| CN104055814B (en) | A kind of preparation method of American Ginseng broken wall preparation | |
| CN106265562A (en) | A kind of ganoderan dispersible tablet and preparation method thereof | |
| CN106387915B (en) | Qi and coffee vigor-benefiting effervescent tablet and preparation process and application thereof | |
| CN105477182A (en) | Ocellated puffer liver oil Chinese herbal health care oral liquid capable of resisting tumors and enhancing immunity and preparation method of oral liquid | |
| CN109464509A (en) | A kind of preparation method of Dan peach kernel granule | |
| CN1785300A (en) | Zuojin fast dispersion solid medicine and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |