CN1785300A - Zuojin fast dispersion solid medicine and its preparation method - Google Patents
Zuojin fast dispersion solid medicine and its preparation method Download PDFInfo
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Abstract
A fast dispersing solid Chinese medicine ''Zuojin'' is prepared from coptis root and evodia fruit through crushing or extracting, superfine pulverizing, and mixing with disintegrant, adhesive, suspending aid, flowing aid, flavouring and coloring agent.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, particularly relate to fast dispersion solid medicine of a kind of and Chinese medicine patent medicine left side gold and preparation method thereof.
Technical background
" 2000 editions contained Zuojin Wans of Chinese pharmacopoeia (Rhizoma Coptidis, Fructus Evodiae consumption proportion are 6: 1) have pathogenic fire purging, and are soothing the liver, stomach function regulating, and the effect of pain relieving is used for liver-fire invading the stomach, abdominal and hypochondriac pain, bitter taste is noisy, acid regurgitation, not desire for hot drinks card.Its prescription and preparation method are: Rhizoma Coptidis 600g, and Fructus Evodiae 100g is ground into fine powder, sieves, and mixing is used water pill, drying, promptly.
Superfine communication technique is meant the material particles more than 3 millimeters is crushed to process below 100 microns.Researcher thinks, because granular size develops to miniaturization, thus can cause surface area and porosity to increase very significantly, so the micronizing body has unique physics and chemical property.For example, have fine solubility, dispersibility, adsorptivity, chemism etc., so application is very extensive.Studies show that all available micronizing apparatus processing of raw material such as many edible animals and plants, microorganism, medicine become superfine powder, the medicine of miniaturization has very strong surface adsorption power and affinity, therefore, has good dispersibility and dissolubility, assimilates easily.
Dispersible preparation is that a kind of water that do not need in the oral cavity can disintegrate or dissolved preparation fast.Requirement has: 1. in the oral cavity rapidly disintegrate, no grittiness, good mouthfeel, swallow easily, to the oral mucosa nonirritant.Should stipulate under the character item in the quality standard: disintegrate rapidly, no grittiness, good mouthfeel in the oral cavity; 2. set up suitable disintegration time mensuration method and limit, and be incorporated into standard; 3. to insoluble medicine, should set up suitable dissolution determination method and limit; 4. other should meet general rule requirement under the tablet item.The characteristics of dispersible preparation are fast: 1. absorption is fast, bioavailability is high; 2. instructions of taking does not need water 3. intestinal is residual few, few side effects; 4. avoid the first pass effect of liver sausage.
Zuojin Wan has had launch to sell at home, but in the practice, the weak point of Zuojin Wan is that preparation technology is outmoded, and dosage form is a water-honeyed pill, uses inconvenience, brings many troubles for the patient of old, children and dysphagia.The present invention adopts superfine communication technique and quick dispersion technology that the Zuojin Wan preparation is transformed, transformation process has overcome the difficulty that Chinese medicine preparation faces in the modified form process, particularly superfine communication technique and quick dispersion technology are applied to the difficulty that Chinese patent medicine faces, as moisture absorption, instability, defective such as technology is loaded down with trivial details is groped through screening and technology, under the constant situation of Chinese medicine preparation, prepared a kind of solid preparation similar to the Zuojin Wan effect with quick disintegration properties.
Summary of the invention
The invention provides a kind of superfine communication technique and quick dispersion technology in conjunction with the new technique that is used for Chinese patent medicine, the quick dispersible preparation of particularly making in conjunction with the technology of preparing of Chinese patent medicine Zuojin Wan similar to the Zuojin Wan effect obtained beyond thought effect.
Quick dispersible preparation of the present invention be with the Chinese medicine principal agent through after pulverizing and/or extracting processing, with at least a disintegrating agent with meet water to form full-bodied swelling adjuvant formulated, said preparation is met water disintegrate and form uniform viscosity suspension rapidly.
The quick dispersible preparation of the present invention, the prescription of its Chinese medicine part is composed as follows:
600 parts of Rhizoma Coptidis, 100 parts of Fructus Evodiaes.
More than form, part is a weight portion, calculates with crude drug, if with the gram is unit, can be made into 1000 agent medicine preparations, described 1000 doses of fingers, the final drug preparation of making, as make 1000 of capsule preparations, 1000 in tablet, granule 1000g, oral liquid 1000ml etc. also can make big packing as granule, as the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be a unit with milli part also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, and for especial patient, the proportioning of can corresponding adjustment forming increases or reduce being no more than 100%.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Its adjuvant of quick dispersible preparation of the present invention is significant to the present invention, and adjuvant of the present invention is selected from disintegrating agent, adhesive, suspending (thickening) agent, fluidizer, correctives, rectifys toner.Wherein suspending (thickening) agent, strong toner add according to the needs of preparation, if preparation does not need, just do not add.
The used adjuvant of the present invention obtains through screening, wherein disintegrating agent is selected from, super carboxymethyl starch sodium (upright collapsing), carboxymethyl starch sodium (CMS-Na), low-substituted hydroxypropyl cellulose (LS-HPC), crospolyvinylpyrrolidone (polyvinylpolypyrrolidone, PVPP), cross-linking sodium carboxymethyl cellulose (CCMC-Na, CCNa), low-substituted hydroxypropyl cellulose (LHPC) etc.For the less starch of swellbility, microcrystalline Cellulose etc. can guarantee the quick disintegrate of preparation (also can use under＜3min) the situation, but preferably swellbility greater than the disintegrating agent of 5ml/g.Adhesive is selected from polyvidone (PVP), for hyprolose sodium (HPMC); Suspending agent is selected from xanthan gum, Ka Baimu (CARBOMER), HPMC, melon glue.Fluidizer is selected from differential silica gel, Pulvis Talci, magnesium stearate.Correctives is selected from various essence, as Apis essence, green tea essence, Fructus Citri tangerinae essence, apple essence, flavoring pineapple essence, grape essence etc.Strong toner is any pharmaceutically useful pigment or makes the final user mode of preparation present the coloring matter that meets medicinal standard of certain color state.
The present invention also provides the preparation method of quick dispersible preparation of the present invention, this preparation method comprises, Chinese medicine pulverizing medicinal materials and/or extraction with above proportioning, ground product or extract obtain product after drying, through micronizing, obtain medicinal powder or the extract powder of particle diameter less than 75 μ m, this powder is as active constituents of medicine, mixed in the proper ratio with adjuvant through micronizing, make quick dispersible preparation of the present invention with the preparation technique of galenic pharmacy routine.Chinese medicine pulverizing medicinal materials described in this method can be according to traditional method as " 2000 editions contained preparation methoies of Chinese pharmacopoeia: Rhizoma Coptidis 600g, Fructus Evodiae 100g is ground into fine powder, sieve, mixing, promptly.
Described extraction can use decocting in water to extract, alcohol reflux, and ethanol percolation extracts, and the decocting in water precipitate with ethanol extracts, and any one in the multiple extracting method such as alcohol heavy extraction to boil water selected to use as required, and preferably decocting in water extracts.Decocting in water adopts and adds water 10-15 doubly, and decocting boils 2-3 time, and 1-3 hour for the first time, 1-3 hour for the second time, 1-3 hour for the third time, collecting decoction filtered, and concentrate drying obtains extract extractum.
In order to provide preparation good quick dispersive ability, need the granularity of strict control active constituents of medicine and adjuvant, just grain diameter is little.Therefore, the process characteristic of preparation of the present invention is, before the preparations shaping active constituents of medicine and adjuvant is all carried out micronization; Its objective is the wettability that increases the powder particle surface, promote the medicine stripping.The present invention adopts the method for micronizing, obtains Chinese medicine medicinal powder or the Chinese medicine extract of particle diameter less than 75 μ m, then with particle diameter quite or littler adjuvant is mixed evenly makes pharmaceutical preparation.For tablet, can adopt powder straight forming, wet granulation molding or dry granulation molding to prepare.
Superfine communication technique of the present invention, principal agent of the present invention and adjuvant are processed into particle diameter less than 75 μ m by existing superfine grinding method, are preferably less than 30 μ m, most preferably be micro powder granule less than 10 μ m, at present, micronization technology has two kinds of chemical method and Mechanical Method.Chemical synthesis can make micron order, submicron order even nano level powder body.The mechanical crushing method cost is low, output is big, be the preparation ultrafine powder main means, now large-scale application in commercial production.Micronizing can be divided into dry pulverization process and waterproof pulverization: different according to the principle that produces crush force in the crushing process, dry pulverization process has several forms such as air-flowing type, dither formula, screw (rod) mill formula, paddle type mill and Self-milling; Waterproof pulverization mainly is colloid mill and homogenizer.The present invention can obtain the product of particle diameter less than 75 μ m by above arbitrary method, preferably uses air-flow dry powder comminuting method.
Therefore, the disintegrating agent of the present invention in material principal agent of guaranteeing to use and adjuvant, adhesive, suspending (thickening) agent, fluidizer, correctives, to rectify toner etc. evenly mixed under all having less than the situation of 75 μ m particle diameters, the preparation solid preparation; Said preparation also has the high dispersive characteristic when being beneficial to absorption, can better absorb, and can take with solid form, also can add to take after making preparation be distributed in the liquid behind the liquid when taking, as use mixing in water for oral taking.
Quick dispersible preparation of the present invention, the part by weight of its principal agent and adjuvant is 100: 1～600, preferably 100: 50-400, more preferably 100: 100-200, wherein the part by weight of principal agent and disintegrating agent is 100: 10～500, preferably 100: 100-400, more preferably 100: 200-300.
Quick dispersible preparation of the present invention includes but not limited to fast disintegrating tablet as oral cavity disintegration tablet, and it can directly place the oral cavity, disperses by saliva, and disintegrate rapidly, no grittiness, good mouthfeel are beneficial to and swallow in the oral cavity.Also can be made into dispersible tablet, disperse fast in water, its dispersion liquid does not have grittiness, good mouthfeel, absorbs rapidly.
The weight proportion of principal agent of the present invention and adjuvant is preferably following proportioning:
100 parts of principal agents
Disintegrating agent, 10-500 part
Adhesive, 1-10 part
Suspending (thickening) agent, 0-10 part
Fluidizer, 0.5-5 part
Correctives, 0-2 part
Rectify toner.0-2 part
Wherein, preferred disintegrating agent is super carboxymethyl starch sodium (upright collapsing), carboxymethyl starch sodium (CMS-Na), microcrystalline Cellulose.Preferred adhesive is selected from polyvidone (PVP), for hyprolose sodium (HPMC).Preferred fluidizer is a differential silica gel.Preferred correctives is Apis essence, green tea essence.
Most preferred prescription composition of the present invention is listed in the embodiment of the invention.
The preparation method of above Zuojin Wan fast dispersion solid medicine also is used in the preparation of " adding the flavor Zuojin Wan " fast dispersion solid medicine, and this prescription is: 36 parts of Rhizoma Coptidis (Rhizoma Zingiberis Recens is processed), 36 parts of Fructus Evodiaes (Radix Glycyrrhizae is processed), 18 parts of Radix Scutellariaes, 36 parts of Radix Bupleuri, 18 parts of the Radix Aucklandiae, 72 parts of Rhizoma Cyperis (processed with vinegar), 36 parts of Radix Curcumaes, 54 parts of the Radix Paeoniae Albas, 54 parts of Pericarpium Citri Reticulatae Viride (process with vinegar), 54 parts of Fructus Aurantiis (removing the flesh parched with bran), 54 parts of Pericarpium Citri Reticulataes, 54 parts of Rhizoma Corydalis (processed with vinegar), 54 parts of Radix Angelicae Sinensis, 18 parts in Radix Glycyrrhizae.
Quick dispersible preparation of the present invention, its Chinese medicine preparation is identical with Zuojin Wan, and patent medicine has pathogenic fire purging, and is soothing the liver, stomach function regulating, the effect of pain relieving is used for liver-fire invading the stomach, abdominal and hypochondriac pain, bitter taste is noisy, acid regurgitation, not desire for hot drinks card.Medicine in the embodiment of the invention has been carried out experimentation, proved that quick dispersible preparation of the present invention is better than the conventional formulation Zuojin Wan on curative effect, can reach the effect of conventional medicament, more obtained patient's welcome in the use with littler dosage.
The invention has the advantages that: the present invention is on the basis of the Zuojin Wan prescription of determined curative effect and preparation process, adopt vanguard technology technology such as superfine communication technique, increased the dispersion of medical material effectively, and use quickly disintegrated adjuvant, make preparation have the feature of quick dispersion and very big degree of scatter simultaneously, thereby it is convenient that the more former dosage form of medicine is taken, by quick disintegrate (＜3min) reach the purpose that improves bioavailability.Can put into when dispersible tablet uses and take after water disperses, or directly place mouth, become liquid apace, and for this series products of golden preparation of a left side, be particularly suitable for making preparation of the present invention, can solve as dysphagia person (especially old man, child), or the patient's medication problem under the special environment that can not obtain water, provide a great convenience.Wherein particle diameter less than the medicinal powder of 75 μ m or the extract powder adjuvant identical or littler with particle diameter mixed be key factor of the present invention.
Outside the requirement to corresponding drug standard of the quality evaluation of quickly disintegrated solid preparation and official preparation general rule, preparation disintegration time high spot reviews content, disintegration time＜3min.
It has taking convenience, absorption is fast, bioavailability is high and untoward reaction is few, and steady quality is non-hygroscopic, technology is simple etc., the patient who is particularly suitable for old, children and dysphagia takes, and can characteristics such as produce with conventional tablet production technology and equipment, is a kind of good novel form.
The specific embodiment
With specific embodiment the present invention is elaborated below.The golden dispersible tablet in a left side of the present invention, and the solid preparation with quick disintegrate feature of the side of deriving is to make by the represented method of following embodiment, involved method is the technological means that those skilled in the art can grasp and use.Following examples are implementation example of the present invention, and the part embodiment for claim of the present invention must not be interpreted as the restriction to claim of the present invention of going up in all senses.
Embodiment 1
Get Rhizoma Coptidis 6000g, Fructus Evodiae 1000g, micronizing is crossed 400 orders, and per 100 parts of powder and adjuvant are evenly mixed, and the pressed powder or the back tabletting of granulating are with Xin Feier coating material package clothing, promptly.See Table 1.
Table 1 preparation prescription and main evaluation result thereof
| The principal agent amount 1 | Disintegrating agent/consumption | Adhesive/consumption | Fluidizer/consumption | Other 2 | Disintegration time (min) | Dissolution 3 (3min，％) |
| 100 | CMS-Na/10 CMS-Na/80 CMS-Na/500 MCC/50 MCC/100 | PVP/3 PVP/3 PVP/4 PVP/3 PVP/5 | Differential silica gel/1 differential silica gel/1 differential silica gel/1 differential silica gel/1 differential silica gel/1 | 1 1 1 1 1 | 3 0.6 0.4 0.5 0.3 | - 83 81 85 82 |
Annotate: (1) is 100 parts with the principal agent amount, and other supplementary product consumption is a relative quantity, umber.Other is the tender agent etc. of distinguishing the flavor of (down together) (2).(down together)
(3) dissolution investigation method is with reference to " two appendix XC second methods of Chinese pharmacopoeia version in 2000 are carried out, and index components is a berberine hydrochloride, and assay method is with reference to carrying out under the pharmacopeia Zuojin Wan assay item.(down together)
Embodiment 2
Get Rhizoma Coptidis 6000g, Fructus Evodiae 1000g, micronizing is crossed 400 orders, and per 100 parts of powder and adjuvant are evenly mixed, and mixing is used water pill, drying, promptly.See Table 2.
Table 2 preparation prescription and main evaluation result thereof
| The principal agent amount | Disintegrating agent/consumption | Adhesive/consumption | Disintegration time (min) | Dissolution (3min, %) |
| 100 | CMS-Na/50 | PVP/2 | 0.8 | 81.2 |
Embodiment 3
Rhizoma Coptidis (Rhizoma Zingiberis Recens is processed) 36g, Fructus Evodiae (Radix Glycyrrhizae is processed) 36g, Radix Scutellariae 18g, Radix Bupleuri 36g, Radix Aucklandiae 18g, Rhizoma Cyperi (processed with vinegar) 72g, Radix Curcumae 36g, Radix Paeoniae Alba 54g, Pericarpium Citri Reticulatae Viride (process with vinegar) 54g, Fructus Aurantii (removing the flesh parched with bran) 54g, Pericarpium Citri Reticulatae 54g, Rhizoma Corydalis (processed with vinegar) 54g, Radix Angelicae Sinensis 54g, Radix Glycyrrhizae 18g, more than each the flavor, pulverize, cross 300 orders, per 100 parts of powder and adjuvant are evenly mixed, the pressed powder or the back tabletting of granulating are with Xin Feier coating material package clothing, promptly.See Table 3.
Table 3 preparation prescription and main evaluation result thereof
| The principal agent amount | Disintegrating agent/consumption | Adhesive/consumption | Fluidizer/consumption | Other | Disintegration time (min) |
| 100 | Upright collapsing/45 | PVP/3 | Differential silica gel/1 | 1 | 1.2 |
Embodiment 4
Rhizoma Coptidis (Rhizoma Zingiberis Recens is processed) 36g, Fructus Evodiae (Radix Glycyrrhizae is processed) 36g, Radix Scutellariae 18g, Radix Bupleuri 36g, Radix Aucklandiae 18g, Rhizoma Cyperi (processed with vinegar) 72g, Radix Curcumae 36g, Radix Paeoniae Alba 54g, Pericarpium Citri Reticulatae Viride (process with vinegar) 54g, Fructus Aurantii (removing the flesh parched with bran) 54g, Pericarpium Citri Reticulatae 54g, Rhizoma Corydalis (processed with vinegar) 54g, Radix Angelicae Sinensis 54g, Radix Glycyrrhizae 18g, more than each the flavor decoct with water secondary, 10 times, 8 times, each 2 hours, collecting decoction filters, and the filtrate concentrate drying is pulverized, cross 300 orders, per 100 parts of powder and adjuvant are evenly mixed, the pressed powder or the back tabletting of granulating, promptly.See Table 4.
Table 4 preparation prescription and main evaluation result thereof
| The principal agent amount | Disintegrating agent/consumption | Adhesive/consumption | Fluidizer/consumption | Other | Disintegration time (min) |
| 100 | CMS-Na/45 | PVP/2.5 | Differential silica gel/1 | 1 | 2.1 |
Embodiment 5
Get Rhizoma Coptidis 6000g, Fructus Evodiae 1000g decocts with water secondary, the first time, 8 times of water gagings were 2 hours, and the first time second time, 6 times of water gagings were 1 hour, collecting decoction, filter, concentrate, drying under reduced pressure is ground into fine powder, pulverized 300 orders again, per 100 parts of powder and adjuvant are evenly mixed, the pressed powder or the back tabletting of granulating, promptly.See Table 5.
Table 5 preparation prescription and main evaluation result thereof
| The principal agent amount | Disintegrating agent/consumption | Adhesive/consumption | Fluidizer/consumption | Other | Disintegration time (min) | Dissolution (3min, %) |
| 100 | CMS-Na/55 | PVP/3 | Differential silica gel/1 | 1 | 1.9 | 82.3 |
Embodiment 6
Rhizoma Coptidis (Rhizoma Zingiberis Recens is processed) 36g, Fructus Evodiae (Radix Glycyrrhizae is processed) 36g, Radix Scutellariae 18g, Radix Bupleuri 36g, Radix Aucklandiae 18g, Rhizoma Cyperi (processed with vinegar) 72g, Radix Curcumae 36g, Radix Paeoniae Alba 54g, Pericarpium Citri Reticulatae Viride (process with vinegar) 54g, Fructus Aurantii (removing the flesh parched with bran) 54g, Pericarpium Citri Reticulatae 54g, Rhizoma Corydalis (processed with vinegar) 54g, Radix Angelicae Sinensis 54g, Radix Glycyrrhizae 18g, be broken into fine powder, cross 300 orders, per 100 parts of powder and adjuvant are evenly mixed, use general ball, drying, promptly.See Table 6.
Table 6 preparation prescription and main evaluation result thereof
| The principal agent amount | Disintegrating agent/consumption | Adhesive/consumption | Other | Disintegration time (min) |
| 100 | LS-HPC/45 | PVP/3 | 1 | 1.2 |
Claims (10)
1. Zuojin fast dispersion solid medicine, make by following Chinese medicine raw materials by weight proportion, 600 parts of Rhizoma Coptidis, 100 parts of Fructus Evodiaes, it is characterized in that, described fast dispersion solid medicine is after above-mentioned Chinese medicine is pulverized or extracted, carry out micronizing, obtain principal agent, this principal agent mixes with the adjuvant that is selected from disintegrating agent, adhesive, suspending agent, fluidizer, correctives, strong toner, make preparation with the galenic pharmacy routine techniques, wherein the granularity of principal agent that all uses and adjuvant is all less than 75 μ m particle diameters.
2. the fast dispersion solid medicine of claim 1 is characterized in that, wherein the granularity of principal agent that all uses and adjuvant is all less than 30 μ m particle diameters.
3. the fast dispersion solid medicine of claim 1 is characterized in that, wherein the granularity of principal agent that all uses and adjuvant is all less than 10 μ m particle diameters.
4. the fast dispersion solid medicine of claim 1, it is characterized in that, wherein disintegrating agent is selected from, super carboxymethyl starch sodium, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, starch, microcrystalline Cellulose; Adhesive is selected from polyvidone, for hyprolose sodium; Suspending agent is selected from xanthan gum, Ka Baimu, HPMC, melon glue; Fluidizer is selected from differential silica gel, Pulvis Talci, magnesium stearate; Correctives is selected from various essence, and strong toner is any pharmaceutically useful pigment or makes the final user mode of preparation present the coloring matter that meets medicinal standard of certain color state.
5. the fast dispersion solid medicine of claim 1 is characterized in that, is tablet, and it is composed as follows:
100 parts of principal agents
Disintegrating agent, 10-500 part
Adhesive, 1-10 part
Suspending agent, 0-10 part
Fluidizer, 0.5-5 part
Correctives, 0-2 part
Rectify toner.0-2 part
6. the preparation method of the described fast dispersion solid medicine of claim 1 is characterized in that, the process following steps:
(1) get respectively distinguish the flavor of medical material or decoction pieces according to the Chinese medicine preparation in the claim 1, after pulverizing or extracting, carry out the micronizing of granularity less than 75 μ m particle diameters, standby;
(2) resulting micropowders identical or littler with particle diameter is selected from following adjuvant: disintegrating agent, adhesive, suspending agent, fluidizer, correctives or strong toner mix homogeneously are prepared into preparation.
7. preparation method according to claim 6, it is characterized in that, wherein disintegrating agent is selected from, super carboxymethyl starch sodium, carboxymethyl starch sodium, low-substituted hydroxypropyl cellulose, crospolyvinylpyrrolidone, cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose, starch, microcrystalline Cellulose; Adhesive is selected from polyvidone, for hyprolose sodium; Suspending agent is selected from xanthan gum, Ka Baimu, HPMC, melon glue: fluidizer is selected from differential silica gel, Pulvis Talci, magnesium stearate; Correctives is selected from various essence, and strong toner is any pharmaceutically useful pigment or makes the final user mode of preparation present the coloring matter that meets medicinal standard of certain color state.
8. according to the described preparation method of claim 6, it is characterized in that the ratio of principal agent and adjuvant is 100: 1～600 in the preparation.
9. according to the described preparation method of claim 6, it is characterized in that the ratio of principal agent and disintegrating agent is 100: 10～500 in the preparation.
10. according to the described preparation method of claim 6, it is characterized in that described preparation is a tablet, adopt powder straight forming, wet granulation molding or dry granulation molding.
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| CNB2005100872580A CN100515399C (en) | 2005-07-28 | 2005-07-28 | Zuojin fast dispersion solid medicine and its preparation method |
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| CNB2005100872580A CN100515399C (en) | 2005-07-28 | 2005-07-28 | Zuojin fast dispersion solid medicine and its preparation method |
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| CN100515399C CN100515399C (en) | 2009-07-22 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110878A (en) * | 2012-12-10 | 2013-05-22 | 宋爱民 | Traditional Chinese medicine preparation for treating gastric upset |
| CN107049961A (en) * | 2017-04-11 | 2017-08-18 | 洛阳泽达慧康医药科技有限公司 | A kind of Study on Supermicro-pulverization of Traditional Chinese Drugs mouthful collapses particulate composition and preparation method thereof |
| CN111450163A (en) * | 2019-01-18 | 2020-07-28 | 西南大学 | Coptis pharmaceutical composition and application thereof |
-
2005
- 2005-07-28 CN CNB2005100872580A patent/CN100515399C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110878A (en) * | 2012-12-10 | 2013-05-22 | 宋爱民 | Traditional Chinese medicine preparation for treating gastric upset |
| CN103110878B (en) * | 2012-12-10 | 2014-08-13 | 宋爱民 | Traditional Chinese medicine preparation for treating gastric upset |
| CN107049961A (en) * | 2017-04-11 | 2017-08-18 | 洛阳泽达慧康医药科技有限公司 | A kind of Study on Supermicro-pulverization of Traditional Chinese Drugs mouthful collapses particulate composition and preparation method thereof |
| CN111450163A (en) * | 2019-01-18 | 2020-07-28 | 西南大学 | Coptis pharmaceutical composition and application thereof |
| CN111450163B (en) * | 2019-01-18 | 2021-10-08 | 西南大学 | Coptis pharmaceutical composition and application thereof |
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| CN100515399C (en) | 2009-07-22 |
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