CN108567803A - A kind of preparation method of Jinshuibao gold size capsule - Google Patents
A kind of preparation method of Jinshuibao gold size capsule Download PDFInfo
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- CN108567803A CN108567803A CN201810693394.1A CN201810693394A CN108567803A CN 108567803 A CN108567803 A CN 108567803A CN 201810693394 A CN201810693394 A CN 201810693394A CN 108567803 A CN108567803 A CN 108567803A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Abstract
The present invention relates to a kind of preparation method of Jinshuibao gold size capsule, the Jinshuibao gold size capsule is prepared by following supplementary material：Fermentation cordyceps (Cs 4) 400g, American Ginseng：97g, magnesium stearate：3g, Tween 80：2.5 7.5g, the preparation method, steps are as follows：Fermentation cordyceps (Cs 4) are taken, are smashed, 40 mesh screens are crossed；American Ginseng is taken, is smashed, 40 mesh screens are crossed；It is spare；Take fermentation cordyceps (Cs 4) powder, ginseng powder, Tween 80 be added, water 800g grinds 10 30min using colloid mill, dry, granulation, be filled into capsulae vacuus to get.
Description
Technical field
The invention belongs to pharmaceutical field, more particularly to a kind of preparation method of Jinshuibao gold size capsule.
Background technology
It is main former that Jinshuibao gold size capsule, which is with peacilomyce hepiahi bacterium filament (fermentation cordyceps Cs-4), American Ginseng,
Material, is prepared.
Wherein, fermentation cordyceps are to extract authentic Chinese caterpillar fungus strain (Cs-4) in the fresh natural cordyceps of Qinghai production,
Cordyceps mycelia is made through Submerged fermentation.Fermentation cordyceps (Cs-4) are derived from cordyceps sinensis, active ingredient and effect and day
Right cordyceps sinensis is similar, before more than 1000 years《Hide book on Chinese herbal medicine》In just have the medicinal record of cordyceps sinensis, " cordyceps sinensis property sweet in flavor
It is flat, enter the warp of kidney lung two, protect lung kidney-nourishing, mend marrow, hemostasis and phlegm, overstrain cough, it is all good to control diaphragm disease ".Nourishing lung and kidney, secret lean gas,
For deficiency of both the lung and kidney, vital essence is insufficient, chronic cough and dyspnea of deficiency type, spiritlessness and weakness, insomnia and amnesia, soreness and weakness of waist and knees, the diseases such as irregular menstruation.To the west of matching
American ginseng boosting qi and nourishing yin, relieves inflammation or internal heat and promotes the production of body fluid, and the two combines rear sweet in flavor warm-natured, and pharmacological property is gentle, return lung kidney two warp, mends without high, two medicines close
With complementing each other.
Jinshuibao gold size capsule have it is antifatigue, boost metabolism, strengthen immunity, anti-aging, anti anoxia, anti-height
Temperature, cold-resistant effect, can adjust prolonged fatigue leads to internal metabolic disorder, is the superior good merchantable brand of regulating body function.
Related patents at present without the preparation method of Jinshuibao gold size capsule disclosed in Chinese patent, but use prior art system
Standby Jinshuibao gold size capsule is due to containing only fermentation cordyceps, American Ginseng and magnesium stearate, since drug ingedient combination is excessively tight
It is close, lead to capsule 's content prolonged disintegration, release is slow, influences the absorption of drug in vivo.
Colloid mill is the machinery that fluid foods are carried out with retrofit.It combines homogenizer, ball mill, three-roller, cuts
The multiple performance of the machinery such as machine, blender is cut, there is superior ultramicro grinding, dispersion and emulsion, homogeneous, mixing and other effects.Material
After processing, for granularity up to 2~50 microns, homogeneity is the equipment of ultra micron processing up to 90% or more.Suitable for pharmacy, food
The wet stock ultramicro grinding of product, chemical industry and other industry can play the crushing of various semi-moist bodies and emulsion substance, emulsification,
Matter and mixing.
Screening is optimized to existing prescription and preparation method in the present invention, introduces colloid mill grinding technique, unexpected to send out
Existing, Jinshuibao gold size capsule prepared by method using the present invention effectively raises release and bioavilability.
Invention content
Present invention aims at provide a kind of preparation method of Jinshuibao gold size capsule.
Capsule prepared by the method for the present invention, the effect of can effectively improving this product.
Preparation method of the present invention, includes the following steps：
Prescription：
Fermentation cordyceps (Cs-4) 400g
American Ginseng：97g
Magnesium stearate：3g
Tween-80：2.5-7.5g
Preparation method：
The fermentation cordyceps (Cs-4) of recipe quantity are taken, are smashed, 40 mesh screens are crossed；The American Ginseng of recipe quantity is taken, is smashed, mistake
40 mesh screens；It is spare；Fermentation cordyceps (Cs-4) powder, ginseng powder are taken, is added the Tween-80 of recipe quantity, purified water 800g,
10-30min is ground using colloid mill, magnesium stearate is added in dry, whole grain, always mixes 30min, dry, filling to get.
The preparation method of the present invention is obtained by screening, and screening process is as follows：
Experiment one, wetting agent：Tween-80 dosage is screened
Preparation method：The fermentation cordyceps (Cs-4) of recipe quantity are taken, are smashed, 40 mesh screens are crossed；Take the West of recipe quantity
Ginseng smashes, and crosses 40 mesh screens；It is spare；Fermentation cordyceps (Cs-4) powder, ginseng powder are taken, suitable Tween-80 is added, it is pure
Change water 800g, 10-30min is ground using colloid mill, dry, magnesium stearate is added in whole grain, always mixes 30min, dry, filling, i.e.,
.Lot number is 170301.
170301 adenosine content 250.6mg/100g after measured.By the way that the Tween-80 of different amounts is added in prescription, with this
The dissolution rate of product adenosine is in-vitro evaluation index, screens the optimum amount of Tween-80 and is carried out with the prescription for being not added with Tween-80 molten
Out-degree compares.
Detection method：With sample time (0min, 5min, 10min, 15min, 20min, 30min) for abscissa, adenosine is molten
Out-degree is ordinate, draws stripping curve.
1 Tween-80 dosage of table is screened
| Tween-80 dosage | 0g | 2.5g | 5.0g | 7.5g |
| Prepare total amount | 500g | 500g | 500g | 500g |
When Tween-80 dosage is 0g, measure the adenosine content result (being shown in Table 2) and stripping curve of each time (see attached drawing 1)
It is as follows：
2 each time point adenosine content (Tween-80 dosage of table：2.5g
Tween-80 dosage be 2.5g when, measure each time adenosine content result (being shown in Table 3) and stripping curve (see attached drawing
2) as follows：
3 each time point adenosine content (Tween-80 dosage of table：2.5g)
Tween-80 dosage be 5.0g when, measure each time adenosine content result (being shown in Table 4) and stripping curve (see attached drawing
3) as follows：
4 each time point adenosine content (Tween-80 dosage of table：5.0g)
Tween-80 dosage be 7.5g when, measure each time adenosine content result (being shown in Table 5) and stripping curve (see attached drawing
4) as follows：
5 each time point adenosine content (Tween-80 dosage of table：7.5g)
Using adenosine dissolution rate when 5min as evaluation index, as a result summarize show it is as follows：
6 Tween-80 dosage the selection result of table
The result shows that：After Tween-80 is added, 5min adenosine dissolution rates are substantially better than the prescription not being added, when Tween-80 is used
When amount is no less than 5.0g, 85% or more, and with the increase of Tween-80, dissolution rate becomes 5min adenosines dissolution rate without increase
Gesture.
Experiment two, the screening of colloid milling time
Preparation method：The fermentation cordyceps (Cs-4) of recipe quantity are taken, are smashed, 40 mesh screens are crossed；Take the West of recipe quantity
Ginseng smashes, and crosses 40 mesh screens；It is spare；Fermentation cordyceps (Cs-4) powder, ginseng powder are taken, the Tween-80 of recipe quantity is added,
Purified water 800g grinds 10-30min using colloid mill, and dry, magnesium stearate is added in whole grain, always mixes 30min, dry, filling,
To obtain the final product.
Detect object：Take grind 10min, 15min, 20min, 25min, 30min preparation respectively using colloid mill four batches
Capsule and the batch of capsule ground without colloid mill, dissolve out under the same conditions, and it is molten that adenosine is measured by sampling when dissolving out 5min
Out-degree.
Experimental result：
The result shows that：Milling time reaches 20min, almost all dissolution rate.
By above-mentioned experiment, the best dosage of this product Tween-80 and colloid milling time are determined.
Compared to the prior art advantages of the present invention is as follows
Description of the drawings
Fig. 1：Tween-80 dosage be 0g when, the Jinshuibao gold size capsule of preparation, sample time (0min, 5min, 10min,
15min, 20min, 30min) it is abscissa, adenosine dissolution rate is the dissolution curve that ordinate is drawn.
Fig. 2：Tween-80 dosage be 2.5g when, the Jinshuibao gold size capsule of preparation, sample time (0min, 5min,
10min, 15min, 20min, 30min) it is abscissa, adenosine dissolution rate is the dissolution curve that ordinate is drawn.
Fig. 3：Tween-80 dosage be 5.0g when, the Jinshuibao gold size capsule of preparation, sample time (0min, 5min,
10min, 15min, 20min, 30min) it is abscissa, adenosine dissolution rate is the dissolution curve that ordinate is drawn.
Fig. 4：Tween-80 dosage be 7.5g when, the Jinshuibao gold size capsule of preparation, sample time (0min, 5min,
10min, 15min, 20min, 30min) it is abscissa, adenosine dissolution rate is the dissolution curve that ordinate is drawn.
Specific implementation mode
It further illustrates the present invention by the following examples.
Embodiment 1
Fermentation cordyceps (Cs-4) 400g
American Ginseng：97g
Magnesium stearate：3g
Tween-80：5.0g
Preparation method：
The fermentation cordyceps (Cs-4) of recipe quantity are taken, are smashed, 40 mesh screens are crossed；The American Ginseng of recipe quantity is taken, is smashed, mistake
40 mesh screens；It is spare；Fermentation cordyceps (Cs-4) powder, ginseng powder are taken, is added the Tween-80 of recipe quantity, purified water 800g,
20min is ground using colloid mill, magnesium stearate is added in dry, whole grain, always mixed 30min dryings, filling to get.
Embodiment 2：
Formulation and technology is as follows：
Fermentation cordyceps (Cs-4) 400g
American Ginseng：97g
Magnesium stearate：3g
Tween-80：2.5g
Preparation method：
The fermentation cordyceps (Cs-4) of recipe quantity are taken, are smashed, 40 mesh screens are crossed；The American Ginseng of recipe quantity is taken, is smashed, mistake
40 mesh screens；It is spare；Fermentation cordyceps (Cs-4) powder, ginseng powder are taken, is added the Tween-80 of recipe quantity, purified water 800g,
10min is ground using colloid mill, magnesium stearate is added in dry, whole grain, always mixed 30min dryings, filling to get.
Embodiment 3：
Formulation and technology is as follows：
Fermentation cordyceps (Cs-4) 400g
American Ginseng：97g
Magnesium stearate：3g
Tween-80：7.5g
Preparation method：
The fermentation cordyceps (Cs-4) of recipe quantity are taken, are smashed, 40 mesh screens are crossed；The American Ginseng of recipe quantity is taken, is smashed, mistake
40 mesh screens；It is spare；Fermentation cordyceps (Cs-4) powder, ginseng powder are taken, is added the Tween-80 of recipe quantity, purified water 800g,
20min is ground using colloid mill, magnesium stearate is added in dry, whole grain, always mixed 30min dryings, filling to get.
Embodiment 4：
Formulation and technology is as follows：
Fermentation cordyceps (Cs-4) 400g
American Ginseng：97g
Magnesium stearate：3g
Tween-80：5.0g
Preparation method：
The fermentation cordyceps (Cs-4) of recipe quantity are taken, are smashed, 40 mesh screens are crossed；The American Ginseng of recipe quantity is taken, is smashed, mistake
40 mesh screens；It is spare；Fermentation cordyceps (Cs-4) powder, ginseng powder are taken, is added the Tween-80 of recipe quantity, purified water 800g,
25min is ground using colloid mill, magnesium stearate is added in dry, whole grain, always mixed 30min dryings, filling to get.
Claims (5)
1. a kind of preparation method of Jinshuibao gold size capsule, which is characterized in that the Jinshuibao gold size capsule is by following supplementary material system
It is standby to form：
Prescription
Fermentation cordyceps (Cs-4) 400g
American Ginseng：97g
Magnesium stearate：3g
Tween-80：2.5-7.5g
Preparation method：
Fermentation cordyceps (Cs-4) are taken, are smashed, 40 mesh screens are crossed；American Ginseng is taken, is smashed, 40 mesh screens are crossed；It is spare；Take fermentation
Tween-80 is added in cordyceps (Cs-4) powder, ginseng powder, and purified water 800g grinds 10-30min using colloid mill, dry,
Magnesium stearate is added in whole grain, always mixes 30min, dry, filling to get.
2. preparation method according to claim 1, which is characterized in that wetting agent used in it uses Tween-80, dosage
In 2.5-7.5g.
3. preparation method according to claim 1, which is characterized in that wherein colloid mill lapping mode is used to mix, mixing
Time is in 10-30min.
4. preparation method according to claim 1, which is characterized in that steps are as follows：
Prescription
Fermentation cordyceps (Cs-4) 400g
American Ginseng：97g
Magnesium stearate：3g
Tween-80：5.0g
Fermentation cordyceps (Cs-4) are taken, are smashed, 40 mesh screens are crossed；American Ginseng is taken, is smashed, 40 mesh screens are crossed；It is spare；Take fermentation
Tween-80 is added in cordyceps (Cs-4) powder, ginseng powder, and purified water 800g grinds 20min using colloid mill, dry, whole
Magnesium stearate is added in grain, always mixes 30min, dry, filling to get.
5. preparation method according to claim 1, which is characterized in that steps are as follows：
Prescription
Fermentation cordyceps (Cs-4) 400g
American Ginseng：97g
Magnesium stearate：3g
Tween-80：7.5g
Fermentation cordyceps (Cs-4) are taken, are smashed, 40 mesh screens are crossed；American Ginseng is taken, is smashed, 40 mesh screens are crossed；It is spare；Take fermentation
Tween-80 is added in cordyceps (Cs-4) powder, ginseng powder, and purified water 800g grinds 10-30min using colloid mill, dry,
Magnesium stearate is added in whole grain, always mixes 30min, dry, filling to get.
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| CN201810693394.1A CN108567803B (en) | 2018-06-29 | 2018-06-29 | Preparation method of Jinshuibaojin capsules |
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| CN201810693394.1A CN108567803B (en) | 2018-06-29 | 2018-06-29 | Preparation method of Jinshuibaojin capsules |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640488A (en) * | 2004-01-09 | 2005-07-20 | 蒋朝宗 | Method for preparing supermicro powder preparation of cordyceps sinensis mycelium |
| CN1887300A (en) * | 2005-06-27 | 2007-01-03 | 仁和（集团）发展有限公司 | Chinese medicine composition and its prepn process and quality control method |
| CN102335212A (en) * | 2011-09-26 | 2012-02-01 | 江西济民可信集团有限公司 | Chinese medicine Jinshuibao golden pill preparation and preparation method thereof |
| CN102365098A (en) * | 2009-01-30 | 2012-02-29 | 明治制果药业株式会社 | Finely pulverized pharmaceutical composition |
| CN102488673A (en) * | 2011-12-06 | 2012-06-13 | 沈阳药科大学 | Probucol nanometer dispersion and preparation method thereof |
-
2018
- 2018-06-29 CN CN201810693394.1A patent/CN108567803B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1640488A (en) * | 2004-01-09 | 2005-07-20 | 蒋朝宗 | Method for preparing supermicro powder preparation of cordyceps sinensis mycelium |
| CN1887300A (en) * | 2005-06-27 | 2007-01-03 | 仁和（集团）发展有限公司 | Chinese medicine composition and its prepn process and quality control method |
| CN102365098A (en) * | 2009-01-30 | 2012-02-29 | 明治制果药业株式会社 | Finely pulverized pharmaceutical composition |
| CN102335212A (en) * | 2011-09-26 | 2012-02-01 | 江西济民可信集团有限公司 | Chinese medicine Jinshuibao golden pill preparation and preparation method thereof |
| CN102488673A (en) * | 2011-12-06 | 2012-06-13 | 沈阳药科大学 | Probucol nanometer dispersion and preparation method thereof |
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