CN106265562A - A kind of ganoderan dispersible tablet and preparation method thereof - Google Patents

A kind of ganoderan dispersible tablet and preparation method thereof Download PDF

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Publication number
CN106265562A
CN106265562A CN201610658714.0A CN201610658714A CN106265562A CN 106265562 A CN106265562 A CN 106265562A CN 201610658714 A CN201610658714 A CN 201610658714A CN 106265562 A CN106265562 A CN 106265562A
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CN
China
Prior art keywords
parts
ganoderan
dispersible tablet
ganoderma lucidum
crude polysaccharide
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Pending
Application number
CN201610658714.0A
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Chinese (zh)
Inventor
吕兴萍
管斌
凡军民
杨薇红
吴泽仟
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Jiangsu Polytechnic College of Agriculture and Forestry
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Jiangsu Polytechnic College of Agriculture and Forestry
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Priority to CN201610658714.0A priority Critical patent/CN106265562A/en
Publication of CN106265562A publication Critical patent/CN106265562A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention provides a kind of ganoderan dispersible tablet, it is mainly made up of the raw material of following weight ratio: ganoderma lucidum crude polysaccharide 70～140 parts, filler 30～60 parts, disintegrating agent 20～35 parts, correctives 7～22 parts, lubricant 2～5 parts, wetting agent is appropriate.Compared with prior art, ganoderan dispersible tablet of the present invention, can complete disintegrate in 3min in 19～21 DEG C of water, its dispersion is fast, rapid-action, in good taste, carries, stores conveniently, and can swallow or be mixed in water and drink, easy to use；Additionally, ganoderan dispersible tablet of the present invention can also overcome the defect of existing preparation, it is greatly improved its stability, provides a kind of new selection for ganoderan as health product exploitation, have broad application prospects.

Description

A kind of ganoderan dispersible tablet and preparation method thereof
Technical field
The present invention relates to a kind of ganoderan dispersible tablet and preparation method thereof, belong to health product technology field.
Background technology
Ganoderma (Ganoderma Lucidum), ancient title Ganoderma, it is basidiomycetes section Ganoderma fungus, there is strengthening the body resistance, taste The effects such as reinforcement is strong.There is the history of more than 2000 year in China as medicine, the most just have the good reputation of " Herba mesonae chinensis ".Ganoderan is spirit The main active of sesame, has immunomodulating, antitumor, antioxidation, radioprotective, defying age and blood circulation promoting and blood stasis dispelling etc. widely Pharmacologically active, Healthy People also is intended to often to take, and therefore ganoderan is a focus of research at present.In the U.S., by spirit Sesame, with hot water extraction, obtains with membrane filtration purification further, is proteoglycan, is used for daily meals supply；In China, Ganoderma Diluted Alcohol is extracted, obtains with straight alcohol purification further, be peptide polysaccharide, be used for OTC class medicine.
The product of ganoderan is capsule, powder, liquid beverage etc. mostly at present, and ganoderan hygroscopicity is relatively strong, dissipates Agent is often lumpd, and unfavorable use and stores；Capsule often needs one day to take repeatedly, the most often need to use multi-disc (grain), need to use mixing in water for oral taking, Take inconvenience, especially to giving old, children and having the people of dysphagia to have certain difficulty；And liquid beverage is often due to itself Enzyme or microbial deterioration or corruption, be unfavorable for storage, and volume be big, weight is big, is unfavorable for storing and transport.
Summary of the invention
Goal of the invention: in order to overcome the deficiencies in the prior art, the invention provides a kind of ganoderan dispersible tablet And preparation method thereof.
Technical scheme: for achieving the above object, the present invention provides a kind of ganoderan dispersible tablet, and it is mainly by following weight The raw material of part ratio is made:
Ganoderma lucidum crude polysaccharide 70～140 parts, filler 30～60 parts, disintegrating agent 20～35 parts, correctives 7～22 parts,
Lubricant 2～5 parts, wetting agent is appropriate.
As preferably, described ganoderan dispersible tablet is mainly made up of the raw material of following weight ratio:
Ganoderma lucidum crude polysaccharide 88 parts, filler 34～49 parts, disintegrating agent 20～35 parts, correctives 12～18 parts,
Lubricant 2～5 parts, wetting agent is appropriate.
Preferred as another kind, described ganoderan dispersible tablet is mainly made up of the raw material of following weight ratio:
Ganoderma lucidum crude polysaccharide 88 parts, microcrystalline Cellulose 44 parts, polyvinylpolypyrrolidone 25 parts, aspartame 15 parts,
Micropowder silica gel 3.5 parts, 75% appropriate amount of ethanol.
Preferred as another kind, described ganoderma lucidum crude polysaccharide is made up of following steps: Ganoderma section adds water to submerge, and decocts 1h, screen cloth sieves, collect medicinal liquid, medicinal residues repeat to decoct 3 times, merge leachate, leachate concentrate, be vacuum dried Ganoderma is the most Sugar.
Preferred as another kind, described filler is starch, calcium sulfate or microcrystalline Cellulose.
Preferred as another kind, described disintegrating agent is cross-linking sodium carboxymethyl cellulose, low-substituted hydroxypropyl cellulose or friendship Connection polyvidone.
Preferred as another kind, described correctives is aspartame.
Preferred as another kind, described lubricant is magnesium stearate, Pulvis Talci or micropowder silica gel.
Preferred as another kind, described wetting agent be concentration be the ethanol solution of 50～95%.
Present invention also offers the preparation method of described ganoderan dispersible tablet, comprise the following steps:
By proportioning, the disintegrating agent of ganoderma lucidum crude polysaccharide, filler, correctives and 50% recipe quantity is mixed, add appropriate moistening Agent soft material, makes wet grain, is then dried, granulate, is eventually adding disintegrating agent and the lubricant of residue recipe quantity, mixes, tabletting, i.e. ?.
Dispersible tablet is complete disintegrate in general 3min in (20 ± 1) DEG C water, and being formed after disintegrate can be clear by 710 μm aperture sieve Clear or slightly lacteous aqueous solution or suspension.Working condition is without particular/special requirement, and dispersible tablet can add water-dispersible deutostoma clothes, also Dispersible tablet can be contained in mouth and suck clothes or swallow.Therefore ganoderan is made dispersible tablet, not only provide multiple making to consumer Select by mode, and dispersible tablet has the advantage of oral solid formulation and oral liquid concurrently, there is dispersion height, dissolution speed Degree is fast, absorb fast, bioavailability advantages of higher, and to improving curative effect, to expand application significant.
Beneficial effect: compared with prior art, ganoderan dispersible tablet of the present invention, can be complete in 3min in 19～21 DEG C of water Full disintegrate, its dispersion is fast, rapid-action, in good taste, carries, stores conveniently, and can swallow or be mixed in water and drink, user Just；Additionally, ganoderan dispersible tablet of the present invention can also overcome the defect of existing preparation, it is greatly improved its stability, for Ganoderma Polysaccharide provides a kind of new selection as health product exploitation, has broad application prospects.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
Embodiment 1
Prescription:
Ganoderma lucidum crude polysaccharide 35g, microcrystalline Cellulose 17.6g, aspartame 6g, polyvinylpolypyrrolidone 10g,
Micropowder silica gel 1.4g, 75% appropriate amount of ethanol.
Preparation method:
The section of commercially available Ganoderma adds water to submerge, and decocts 1h and sieves with 100 eye mesh screens, collects medicinal liquid, and medicinal residues repeat to decoct 3 times, Merge leachate.Leachate concentrates, and is vacuum dried to obtain ganoderma lucidum crude polysaccharide.
Ganoderma lucidum crude polysaccharide, microcrystalline Cellulose, aspartame and polyvinylpolypyrrolidone 5g being mixed, the ethanol system of addition 75% is soft Material, 12 mesh extrude granulation of sieving, and 60 DEG C are dried, and 12 mesh granulate are subsequently adding 5g polyvinylpolypyrrolidone, and micropowder silica gel always mixes, tabletting, Prepare ganoderan dispersible tablet of the present invention.
Embodiment 2
Prescription:
Ganoderma lucidum crude polysaccharide 35g, microcrystalline Cellulose 15.6g, aspartame 6g, polyvinylpolypyrrolidone 12g,
Micropowder silica gel 1.4g, 75% appropriate amount of ethanol.
Preparation method:
The section of commercially available Ganoderma adds water to submerge, and decocts 1h and sieves with 100 eye mesh screens, collects medicinal liquid, and medicinal residues repeat to decoct 3 times, Merge leachate.Leachate concentrates, and is vacuum dried to obtain ganoderma lucidum crude polysaccharide.
Ganoderma lucidum crude polysaccharide, microcrystalline Cellulose, aspartame and polyvinylpolypyrrolidone 6g being mixed, the ethanol system of addition 75% is soft Material, 12 mesh extrude granulation of sieving, and 60 DEG C are dried, and 12 mesh granulate are subsequently adding 6g polyvinylpolypyrrolidone, and micropowder silica gel always mixes, tabletting, Prepare ganoderan dispersible tablet of the present invention.
Embodiment 3
Prescription:
Ganoderma lucidum crude polysaccharide 35g, microcrystalline Cellulose 13.6g, aspartame 6g, polyvinylpolypyrrolidone 14g,
Micropowder silica gel 1.4g, 75% appropriate amount of ethanol.
Preparation method:
The section of commercially available Ganoderma adds water to submerge, and decocts 1h and sieves with 100 eye mesh screens, collects medicinal liquid, and medicinal residues repeat to decoct 3 times, Merge leachate.Leachate concentrates, and is vacuum dried to obtain ganoderma lucidum crude polysaccharide.
Ganoderma lucidum crude polysaccharide, microcrystalline Cellulose, aspartame and polyvinylpolypyrrolidone 7g being mixed, the ethanol system of addition 75% is soft Material, 12 mesh extrude granulation of sieving, and 60 DEG C are dried, and 12 mesh granulate are subsequently adding 7g polyvinylpolypyrrolidone, and micropowder silica gel always mixes, tabletting, Prepare ganoderan dispersible tablet of the present invention.
Embodiment 4
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 70g, starch 60g, aspartame 22g, cross-linking sodium carboxymethyl cellulose 35g,
Magnesium stearate 5g, 95% appropriate amount of ethanol.
Embodiment 5
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 140g, calcium sulfate 30g, aspartame 7g, low-substituted hydroxypropyl cellulose 20g,
Pulvis Talci 2g, 50% appropriate amount of ethanol.
Embodiment 6
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 88g, microcrystalline Cellulose 34g, aspartame 12g, cross-linking sodium carboxymethyl cellulose 20g,
Pulvis Talci 2g, 60% appropriate amount of ethanol.
Embodiment 7
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 88g, starch 49g, aspartame 18g, polyvinylpolypyrrolidone 35g,
Micropowder silica gel 5g, 80% appropriate amount of ethanol.
Embodiment 8
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 105g, calcium sulfate 30g, aspartame 7g, cross-linking sodium carboxymethyl cellulose 20g,
Magnesium stearate 2g, 70% appropriate amount of ethanol.
Embodiment 9
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 88g, microcrystalline Cellulose 44g, polyvinylpolypyrrolidone 25g, aspartame 15g,
Micropowder silica gel 3.5g, 75% appropriate amount of ethanol.
Embodiment 10
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 88g, microcrystalline Cellulose 44g, cross-linking sodium carboxymethyl cellulose 25g, aspartame 15g,
Micropowder silica gel 3.5g, 75% appropriate amount of ethanol.
Embodiment 11
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 88g, microcrystalline Cellulose 44g, low-substituted hydroxypropyl cellulose 25g, aspartame 15g,
Micropowder silica gel 3.5g, 75% appropriate amount of ethanol.
Embodiment 12
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 88g, starch 44g, polyvinylpolypyrrolidone 25g, aspartame 15g,
Micropowder silica gel 3.5g, 75% appropriate amount of ethanol.
Embodiment 13
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 88g, calcium sulfate 44g, polyvinylpolypyrrolidone 25g, aspartame 15g,
Micropowder silica gel 3.5g, 75% appropriate amount of ethanol.
Embodiment 14
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 70g, microcrystalline Cellulose 35.2g, aspartame 12g, low-substituted hydroxypropyl cellulose 20g,
Micropowder silica gel 2.8g, 75% appropriate amount of ethanol.
Embodiment 15
Preparation method is with embodiment 1, and difference is that prescription is as follows:
Ganoderma lucidum crude polysaccharide 70g, microcrystalline Cellulose 40.2g, aspartame 7g, polyvinylpolypyrrolidone 20g,
Micropowder silica gel 2.8g, 50% appropriate amount of ethanol.
Experimental example gained of the present invention ganoderan dispersible tablet Performance
Take gained dispersible tablet of the present invention, primarily look at its disintegration, be then accelerated test, temperature be 40 DEG C ± 2 DEG C, relative humidity be place 6 months under conditions of 75% ± 5% after, when investigating its final character, polyoses content and disintegrate Limit.
Condition of investigating disintegration is in 19～21 DEG C of water；
Each group is investigated result and be see table 1.
Table 1 each component discrete piece Performance result
Can obtain from upper table 1 result, gained dispersible tablet of the present invention, can in 19～21 DEG C of water about 110S disintegrate, disintegrative Can dispersion.
Additionally, the embodiment of the present invention 1,2 and 9 gained ganoderan dispersible tablet, after accelerated test, its trait expression is Sheet is the most smooth, gently pinches the most broken, and color is the most unchanged, and polyoses content and disintegration do not have significant change, and show Its stability is high.

Claims (10)

1. a ganoderan dispersible tablet, it is characterised in that it is mainly made up of the raw material of following weight ratio:
Ganoderma lucidum crude polysaccharide 70～140 parts, filler 30～60 parts, disintegrating agent 20～35 parts, correctives 7～22 parts,
Lubricant 2～5 parts, wetting agent is appropriate.
Ganoderan dispersible tablet the most according to claim 1, it is characterised in that its main former by following weight ratio Material is made:
Ganoderma lucidum crude polysaccharide 88 parts, filler 34～49 parts, disintegrating agent 20～35 parts, correctives 12～18 parts,
Lubricant 2～5 parts, wetting agent is appropriate.
Ganoderan dispersible tablet the most according to claim 1, it is characterised in that its main former by following weight ratio Material is made:
Ganoderma lucidum crude polysaccharide 88 parts, microcrystalline Cellulose 44 parts, polyvinylpolypyrrolidone 25 parts, aspartame 15 parts,
Micropowder silica gel 3.5 parts, 75% appropriate amount of ethanol.
Ganoderan dispersible tablet the most according to claim 1, it is characterised in that described ganoderma lucidum crude polysaccharide is by following steps Make: Ganoderma section adds water to submerge, and decocts 1h, and screen cloth sieves, and collects medicinal liquid, and medicinal residues repeat to decoct 3 times, merge leachate, leaching Go out liquid to concentrate, be vacuum dried to obtain ganoderma lucidum crude polysaccharide.
Ganoderan dispersible tablet the most according to claim 1, it is characterised in that described filler be starch, calcium sulfate or Microcrystalline Cellulose.
Ganoderan dispersible tablet the most according to claim 1, it is characterised in that described disintegrating agent is cross-linked carboxymethyl fiber Element sodium, low-substituted hydroxypropyl cellulose or polyvinylpolypyrrolidone.
Ganoderan dispersible tablet the most according to claim 1, it is characterised in that described correctives is aspartame.
Ganoderan dispersible tablet the most according to claim 1, it is characterised in that described lubricant is magnesium stearate, Talcum Powder or micropowder silica gel.
Ganoderan dispersible tablet the most according to claim 1, it is characterised in that described wetting agent be concentration be 50～95% Ethanol solution.
10. the preparation method of the ganoderan dispersible tablet described in any one of claim 1-9, it is characterised in that include following step Rapid:
By proportioning, the disintegrating agent of ganoderma lucidum crude polysaccharide, filler, correctives and 50% recipe quantity is mixed, add appropriate wetting agent system Soft material, makes wet grain, is then dried, granulate, is eventually adding disintegrating agent and the lubricant of residue recipe quantity, mixing, tabletting, to obtain final product.
CN201610658714.0A 2016-08-11 2016-08-11 A kind of ganoderan dispersible tablet and preparation method thereof Pending CN106265562A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107736541A (en) * 2017-09-30 2018-02-27 江苏农林职业技术学院 A kind of GL-B dispersible tablet type solid beverage and its powder vertical compression preparation method
CN108522768A (en) * 2018-02-26 2018-09-14 南昌大学 A kind of preparation method of Black Ganoderma polysaccharide buccal tablets

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103877039A (en) * 2014-02-28 2014-06-25 江西泽众制药股份有限公司 Ganoderma sinense polysaccharide dispersible tablet and preparation method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103877039A (en) * 2014-02-28 2014-06-25 江西泽众制药股份有限公司 Ganoderma sinense polysaccharide dispersible tablet and preparation method thereof

Non-Patent Citations (2)

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Title
傅超美，等: "《药用辅料学》", 31 October 2008, 中国中医药出版社 *
国家药典委员会: "《中华人民共和国药典 2015年版 一部》", 30 June 2015, 中国医药科技出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107736541A (en) * 2017-09-30 2018-02-27 江苏农林职业技术学院 A kind of GL-B dispersible tablet type solid beverage and its powder vertical compression preparation method
CN108522768A (en) * 2018-02-26 2018-09-14 南昌大学 A kind of preparation method of Black Ganoderma polysaccharide buccal tablets

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Application publication date: 20170104