CN107183679A - A kind of cordyceps sinensis instant, tablet and cordyceps militaris liquor for adjusting immunologic function - Google Patents
A kind of cordyceps sinensis instant, tablet and cordyceps militaris liquor for adjusting immunologic function Download PDFInfo
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- CN107183679A CN107183679A CN201710291678.3A CN201710291678A CN107183679A CN 107183679 A CN107183679 A CN 107183679A CN 201710291678 A CN201710291678 A CN 201710291678A CN 107183679 A CN107183679 A CN 107183679A
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- Prior art keywords
- cordyceps
- cordyceps sinensis
- parts
- jujube
- matrimony vine
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- 241001248610 Ophiocordyceps sinensis Species 0.000 title claims abstract description 139
- 241001264174 Cordyceps militaris Species 0.000 title claims abstract description 35
- 230000036737 immune function Effects 0.000 title claims abstract description 10
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 38
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 38
- 239000002994 raw material Substances 0.000 claims abstract description 29
- 241000190633 Cordyceps Species 0.000 claims abstract description 24
- 238000007654 immersion Methods 0.000 claims abstract description 13
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract description 3
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 88
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 44
- 229960005305 adenosine Drugs 0.000 claims description 44
- 241001247821 Ziziphus Species 0.000 claims description 36
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- 235000014101 wine Nutrition 0.000 claims description 17
- 235000013361 beverage Nutrition 0.000 claims description 16
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 16
- 235000019408 sucralose Nutrition 0.000 claims description 16
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- 239000007787 solid Substances 0.000 claims description 9
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 8
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims description 7
- 150000003838 adenosines Chemical class 0.000 claims description 7
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- 239000001963 growth medium Substances 0.000 claims description 7
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- 239000008108 microcrystalline cellulose Substances 0.000 claims description 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 6
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- 238000000605 extraction Methods 0.000 claims description 4
- 235000019359 magnesium stearate Nutrition 0.000 claims description 4
- 235000019991 rice wine Nutrition 0.000 claims description 4
- 235000020097 white wine Nutrition 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 239000000314 lubricant Substances 0.000 claims description 3
- 235000020985 whole grains Nutrition 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 2
- 238000007689 inspection Methods 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims 3
- 244000025254 Cannabis sativa Species 0.000 claims 1
- 239000000284 extract Substances 0.000 abstract description 15
- 235000013305 food Nutrition 0.000 abstract description 6
- 241000233866 Fungi Species 0.000 abstract description 4
- 240000001307 Myosotis scorpioides Species 0.000 abstract description 4
- 238000000227 grinding Methods 0.000 abstract description 4
- 239000000463 material Substances 0.000 abstract description 4
- XLEKNHGPWVDAMJ-WOUKDFQISA-N (2r,3r,4s,5r)-2-[6-(ethoxyamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(NOCC)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O XLEKNHGPWVDAMJ-WOUKDFQISA-N 0.000 abstract 2
- 240000008866 Ziziphus nummularia Species 0.000 abstract 2
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- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 240000006698 Spigelia anthelmia Species 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
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- 238000002474 experimental method Methods 0.000 description 3
- 235000003599 food sweetener Nutrition 0.000 description 3
- 150000004676 glycans Chemical class 0.000 description 3
- 230000003526 lymphopoietic effect Effects 0.000 description 3
- 229920001282 polysaccharide Polymers 0.000 description 3
- 239000005017 polysaccharide Substances 0.000 description 3
- 230000007958 sleep Effects 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000003765 sweetening agent Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- -1 dihydroxy ethyl adenosine Chemical compound 0.000 description 2
- 235000013376 functional food Nutrition 0.000 description 2
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- 208000033065 inborn errors of immunity Diseases 0.000 description 2
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- 239000000725 suspension Substances 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- KVYRCBOUKXJXDK-UHFFFAOYSA-N 3,4-dimethylphenazine-1,2-diamine hydrochloride Chemical compound Cl.C1=CC=CC2=NC3=C(C)C(C)=C(N)C(N)=C3N=C21 KVYRCBOUKXJXDK-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 241001480006 Clavicipitaceae Species 0.000 description 1
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 description 1
- 241000625793 Cordyceps pruinosa Species 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 206010057249 Phagocytosis Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000002082 anti-convulsion Effects 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000000702 anti-platelet effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000003056 antler Anatomy 0.000 description 1
- 206010003549 asthenia Diseases 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 description 1
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000013067 intermediate product Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
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- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000008782 phagocytosis Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/01—Instant products; Powders; Flakes; Granules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/40—Shaping or working of foodstuffs characterised by the products free-flowing powder or instant powder, i.e. powder which is reconstituted rapidly when liquid is added
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Animal Behavior & Ethology (AREA)
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- General Engineering & Computer Science (AREA)
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- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention discloses a variety of health-care food contg. Chinese caterpillar fungus for having and adjusting immunologic function, using N6 (2 ethoxy) adenosine as functional components, with 10 60 parts of cordyceps sinensis, 10 40 parts of jujube, 10 30 parts of matrimony vine is raw material, to raw material cordyceps sinensis, jujube and matrimony vine carry out ultramicro grinding, immersion, ultrasonic extraction, concentration, after drying, the extract of functional components containing cordyceps sinensis N6 (2 ethoxy) adenosine is made, again by extract and different auxiliary material, dispensing is combined, the high health-care food contg. Chinese caterpillar fungus of several functions composition content is made in processing, such as instant cordyceps preparation, Cordyceps sinensis tablet, cordyceps militaris liquor etc..
Description
Technical field
The present invention relates to health-care food contg. Chinese caterpillar fungus, especially using cordyceps sinensis N6- (2- ethoxys) adenosines as the cordyceps sinensis of functional component
Electuary, Cordyceps sinensis tablet and cordyceps militaris liquor.
Background technology
Cordyceps sinensis includes category Ascomycetes, Clavicipitaceae, the Cordyceps such as cordyceps sinensis, Cordyceps militaris, Periostracum cicadae, main distribution
It is the distinctive traditional rare traditional Chinese medicine of China, its strong nourishing function and people in Qinghai, Tibet, Sichuan, Yunnan and zhejiang and other places
Ginseng, pilose antler are run neck and neck.Rare tonic herb by representative of cordyceps sinensis, which has, improves sleep, antitumor, antifatigue, regulation
Immune the effects such as.In recent years, because containing mannitol, Cordyceps sinensis polysaccharide, cordycepin, ergosterol, nucleosides in Cordyceps militaris, Periostracum cicadae
The multiple biological activities composition such as class material, with the approximate function of cordyceps sinensis, is increasingly becoming its substitute, same to have confrontation
The effects such as neurasthenia, calmness, improvement sleep, regulation are immunized.
N6- (2- ethoxys) adenosine (HEA), it was reported that be present in Periostracum cicadae, Cordyceps pruinosa and Cordyceps militaris, be first
The calcium ion antagonist of individual biological source, with effectiveness such as very strong anti-ultraviolet radiation, antiplatelet condensation and analgesias, through bavin one
Autumn etc. proves the effects such as HEA has analgesia, anticonvulsion, improvement sleep and protects kidney.
Worm grass product quality is uneven in the market, and major product is natural cses, the mycelia of artificial cultivation cordyceps sinensis
Body, fructification and converted products, the immune cordyceps sinensis functional food of exploitation regulation by functional component of N6- (2- ethoxys) adenosines,
Not only there is novelty, also absorbed by force, easily with quality controllability, disclosure satisfy that people to mouthfeel, product price and take
Many-sided demand such as band facility, should have high Development volue.
The content of the invention
The present invention be directed to the application present situation of N6- (2- ethoxys) adenosine, it is desirable to provide using N6- (2- ethoxys) adenosines as
The food of functional components, the product is clear and definite relative to the existing Chinese caterpillar fungus health product function in market, easily portable, the side of taking
Just.
In order to reach foregoing invention purpose, the present invention uses following technical scheme：
A kind of cordyceps sinensis instant for adjusting immunologic function, it is characterised in that the cordyceps sinensis instant is with N6- (2- hydroxyls
Ethyl) adenosine is functional components, the preparation method of cordyceps sinensis instant is as follows：
1.1 dry cordyceps sinensis, jujube and matrimony vine to water content less than 5%, by weight ratio：10-60 parts of cordyceps sinensis, jujube
10-40 parts, 10-30 parts of matrimony vine, cordyceps sinensis, jujube and matrimony vine are pulverized and sieved, and are added 10-30 times of pure water immersion 2h, are obtained raw material
Mixed liquor；The cordyceps sinensis is cordyceps sinensis, Periostracum cicadae, Cordyceps militaris and its fructification natural or manually cultivate, mycelia, spore
With the one or more in the remaining culture medium of culture；
1.2 pairs of raw material mixed liquors carry out ultrasonic extraction：25 DEG C are extracted 2 times, 35 minutes every time, after separation of solid and liquid, take supernatant
Concentration, is dried to obtain the Cordyceps of the N6- of functional components containing cordyceps sinensis (2- ethoxys) adenosine；
Cordyceps obtained by step 1.2 and Sucralose are put into mixing machine by 1.3 to be mixed, the addition of Sucralose
For 10-30 parts, quantitative package after oversized particles and powder, autoclaving is rejected in sieving.
Further, the proportioning of each raw material is 20 parts of cordyceps sinensis, 20 parts of jujube, 30 parts of matrimony vine in step 1.1.
The cordyceps sinensis instant of the present invention, with 10-60 parts of cordyceps sinensis, 10-40 parts of jujube, 10-30 parts of matrimony vine, Sucralose
10-30 parts are raw material, raw material cordyceps sinensis, jujube and matrimony vine are carried out after ultramicro grinding, immersion, ultrasonic extraction, concentration, drying, system
The extract of cordyceps sinensis functional components N6- (2- ethoxys) adenosine must be contained, then extract is mixed with Sucralose, obtained height contains
Measure the cordyceps sinensis instant of functional components.
Signified number is parts by weight in the present invention.
The present invention also provides a kind of cordyceps sinensis tablet for adjusting immunologic function, it is characterised in that the cordyceps sinensis tablet is with N6-
(2- ethoxys) adenosine is functional components, and the preparation method of cordyceps sinensis tablet is as follows：
1.1 dry cordyceps sinensis, jujube and matrimony vine to water content less than 5%, by weight ratio：10-60 parts of cordyceps sinensis, jujube
10-40 parts, 10-30 parts of matrimony vine, cordyceps sinensis, jujube and matrimony vine are pulverized and sieved, and are added 10-30 times of pure water immersion 2h, are obtained raw material
Mixed liquor；The cordyceps sinensis is cordyceps sinensis, Periostracum cicadae, Cordyceps militaris and its fructification natural or manually cultivate, mycelia, spore
With the one or more in the remaining culture medium of culture；
1.2 pairs of raw material mixed liquors carry out ultrasonic extraction：25 DEG C are extracted 2 times, 35 minutes every time, after separation of solid and liquid, take supernatant
Concentration, is dried to obtain the Cordyceps of the N6- of functional components containing cordyceps sinensis (2- ethoxys) adenosine；
1.3 add microcrystalline cellulose, Sucralose and citric acid into the Cordyceps obtained by step 1.2, and mixing is equal
Wet grain is made after even；Wherein Cordyceps 62-88 parts, 1-5 parts of microcrystalline cellulose, 10-30 parts of Sucralose, citric acid 1-3
Part；
1.4 to dry wet grain obtained by step 1.3 to moisture at 65 DEG C be 2~3%, crosses 20 eye mesh screen whole grains,
The magnesium stearate for adding 0.5-2 parts in dry particle makees lubricant, is obtained after mixing through tabletting machine containing cordyceps sinensis feature
The cordyceps sinensis tablet of extract；
Quality inspection, packaging after 1.5 autoclavings.
The proportioning of each raw material is 20 parts of cordyceps sinensis, 20 parts of jujube, 30 parts of matrimony vine in step 1.1.
The cordyceps sinensis tablet of the present invention, with 10-60 parts of cordyceps sinensis, 10-40 parts of jujube, 10-30 parts of matrimony vine, Sucralose 10-30
Part, 1-5 parts of microcrystalline cellulose, 10-30 parts of Sucralose, 1-3 parts of citric acid, 0.5-2 parts of magnesium stearate are raw material, to raw material worm
Grass, jujube, matrimony vine are carried out after ultramicro grinding, immersion, concentration, extraction, drying, obtain the N6- of functional components containing cordyceps sinensis (2- hydroxyl second
Base) adenosine extract, then extract and Sucralose, microcrystalline cellulose, Sucralose part, citric acid mixs, are aided with firmly
Fatty acid magnesium, is made the cordyceps sinensis tablet of high content functional components.
3rd purpose of the invention is to provide a kind of cordyceps militaris liquor for adjusting immunologic function, it is characterised in that the cordyceps militaris liquor
Using N6- (2- ethoxys) adenosine as functional components, the preparation method of cordyceps militaris liquor is as follows：
1.1 dry cordyceps sinensis, jujube and matrimony vine to water content less than 5%, by weight ratio：10-60 parts of cordyceps sinensis, jujube
10-40 parts, 10-30 parts of matrimony vine, cordyceps sinensis, jujube and matrimony vine are pulverized and sieved, and are added 10-30 times of pure water immersion 2h, are obtained raw material
Mixed liquor；The cordyceps sinensis is cordyceps sinensis, Periostracum cicadae, Cordyceps militaris and its fructification natural or manually cultivate, mycelia, spore
With the one or more in the remaining culture medium of culture；
1.2 pairs of raw material mixed liquors carry out ultrasonic extraction：25 DEG C are extracted 2 times, 35 minutes every time, after separation of solid and liquid, take supernatant
Concentration, is dried to obtain the Cordyceps of the N6- of functional components containing cordyceps sinensis (2- ethoxys) adenosine；
1.3 are allocated in the following proportions using the Cordyceps obtained by step 1.2 as raw material with beverage wine：
Beverage wine 93-98 parts by weight
Cordyceps 2-7 parts by weight
1.4 are well mixed in a reservoir；
1.5 container closures, and stand more than 12 months at room temperature；
1.6 obtain clear filtrate as cordyceps militaris liquor through double filtration.
Further, the proportioning of raw material is 20 parts of cordyceps sinensis, 20 parts of jujube, 30 parts of matrimony vine in step 1.1.
The proportioning of Cordyceps and beverage wine is：Beverage wine is 95~97.5 parts, 2.5~5 parts of Cordyceps.
Described beverage wine is selected from the white wine of 42-65 degree or the yellow rice wine of 12-28 degree.It is further preferable that described beverage wine
The yellow rice wine of white wine or 22-28 degree selected from 48-52 degree.
The cordyceps militaris liquor of the present invention, with 10-60 parts of cordyceps sinensis, 10-40 parts of jujube, 10-30 parts of raw materials of matrimony vine, to raw material cordyceps sinensis,
Jujube, matrimony vine are carried out after ultramicro grinding, immersion, concentration, extraction, drying, obtain the N6- of functional components containing cordyceps sinensis (2- ethoxys)
The extract of adenosine, then extract and beverage wine are allocated, the cordyceps militaris liquor of high content functional components is made.
The food with regulation immunologic function of the present invention can also be cordyceps sinensis candy, cordyceps sinensis flavouring, cordyceps sinensis chewing gum, worm
Careless milk piece etc.；Health products can also be decoction or granule, or exist in the medicinal extract form as intermediate products.Preferred many
In embodiment, food of the invention is prepared as instant.Compared with prior art, the present invention has the advantage that：
(1) present invention utilizes cordyceps sinensis, Periostracum cicadae, Cordyceps militaris and its fructification of natural or artificial culture, bacterium
One or more in silk, spore and the remaining culture medium of culture, as functional component, are made full use of using N6- (2- ethoxys) adenosine
Worm grass resources, simple production process, it is easy to promote.
(2) the cordyceps sinensis extraction process used, N6- (2- ethoxys) adenosine recovery rate is high, and technique is simple.
(3) raw material proportioning science, health-care effect is splendid.
(4) in addition, the present invention uses Sucralose as sweetener.This sweetener noenergy, sweet taste are pure, height is pacified
Entirely.It is one of current classic functional sweetener.It cannot be only used for overweight people, be also available for diabetes patient, cardiovascular patient
And the elderly uses.Solve the problem of health products such as diabetes patient are single, nutriment is deficient.
Brief description of the drawings
Fig. 1 is that the technology flow for the cordyceps sinensis instant that cordyceps sinensis N6- (2- ethoxys) adenosine is functional components is shown
It is intended to.
Fig. 2 is the technology schematic flow sheet for the cordyceps sinensis tablet that cordyceps sinensis N6- (2- ethoxys) adenosine is functional components.
Fig. 3 is the technology schematic flow sheet for the cordyceps militaris liquor that cordyceps sinensis N6- (2- ethoxys) adenosine is functional components.
Fig. 4 is cordyceps sinensis N6- (2- ethoxys) adenosine examination criteria curve map.
Fig. 5 is cordyceps sinensis N6The hplc schematic diagrames of-(2- ethoxys) adenosine standard specimen.
Fig. 6 is the adenosine content schematic diagram in the instant that cordyceps sinensis N6 dihydroxy ethyls adenosine is functional components.
Fig. 7 is cordyceps sinensis functional components N6- (2- ethoxys) adenosines on lymphopoietic influence schematic diagram.
Embodiment
The embodiment using cordyceps sinensis N6- (2- ethoxys) adenosines as the functional food of functional components of the present invention is simultaneously
Non exhaustive, those skilled in the art belong to the scope of rights protection of the present invention without any conversion of creative work.
Embodiment 1：Cordyceps sinensis N6- (2- ethoxys) adenosine is the instant of functional components
It is that cordyceps sinensis N6- (2- ethoxys) adenosine shows for the technology flow of the instant of functional components shown in Fig. 1
It is intended to.
1. cordyceps militaris sporocarp and/or mycelium are dried to water content after preferably and are not higher than 5%, by weight ratio：
20 parts of cordyceps sinensis, 20 parts of jujube, 30 parts of matrimony vine, just crushing is carried out to the raw material after dispensing with micronizer, using pure water as solvent,
Solid-to-liquid ratio is 1：25 DEG C of ultrasonic extractions after 20, immersion 2h, are extracted 2 times, 35 minutes, separation of solid and liquid every time；Supernatant concentration is obtained
The extract of the functional components containing cordyceps sinensis.
2. adding 20 parts of Sucraloses enters mixing 30 minutes in mixer, crushed with micronizer, use 20 mesh sieves
Net is sieved, extracting screen underflow, is that coarse powder continuation is crushed with micronizer to oversize；Particle is made, big is removed
Grain and powder, with packing machine quantitative separating into every bag of 2g are to obtain cordyceps sinensis functional instant electuary after drying, sterilizing.
Detection cordyceps sinensis N6- (2- ethoxys) adenosine is that the adenosine content of the instant of functional components is 6.39ug/ml.
Embodiment 2：Cordyceps sinensis N6- (2- ethoxys) adenosine is the cordyceps sinensis tablet of functional components
It is that cordyceps sinensis N6- (2- ethoxys) adenosine shows for the technology flow of the cordyceps sinensis tablet of functional components shown in Fig. 2
It is intended to.
1. cordyceps militaris sporocarp and/or mycelium are dried to water content after preferably and are not higher than 5%, by weight ratio：
20 parts of cordyceps sinensis, 20 parts of jujube, 30 parts of matrimony vine, just crushing is carried out to the raw material after dispensing with micronizer, using pure water as solvent,
Solid-to-liquid ratio is 1：10-1：25 DEG C of ultrasonic extractions after 30, immersion 2h, are extracted 2 times, 35 minutes, separation of solid and liquid every time；Supernatant concentration
After obtain cordyceps sinensis feature extract.
2. take 85 parts of the extract of functional components containing cordyceps sinensis obtained by step, add 3 parts of microcrystalline cellulose, 2 parts of citric acid,
15 parts of Sucralose, after being well mixed, is slowly added to 50% ethanol wet agent and wet grain is made.
3. wet grain obtained by upper step is dried into moisture at 65 DEG C to after 2~3%, 20 eye mesh screen whole grains are crossed, in dry particle
Middle 1 part of magnesium stearate of addition makees lubricant, and the Cordyceps sinensis tablet containing cordyceps sinensis feature extract is obtained through tabletting machine after mixing
Agent.
4. quantitative separating is to obtain Cordyceps sinensis tablet agent into every 1g after autoclaving.
Embodiment 3：Cordyceps sinensis N6- (2- ethoxys) adenosine is the cordyceps militaris liquor of functional components
It is the technology flow signal for the cordyceps militaris liquor that cordyceps sinensis N6- (2- ethoxys) adenosine is functional components shown in Fig. 3
Figure.
1. cordyceps militaris sporocarp and/or mycelium are dried to water content after preferably and are not higher than 5%, by weight ratio：
20 parts of cordyceps sinensis, 20 parts of jujube, 30 parts of matrimony vine, just crushing is carried out to the raw material after dispensing with micronizer, using pure water as solvent,
Solid-to-liquid ratio is 1：10-1：25 DEG C of ultrasonic extractions after 30, immersion 2h, are extracted 2 times, 35 minutes, separation of solid and liquid every time；Supernatant concentration
After obtain cordyceps sinensis feature extract.
2. it is by weight with beverage wine by Cordyceps：Beverage wine is 95~97.5 parts, Cordyceps 2.5~5
Part ratio be well mixed in a reservoir, beverage wine is 48-52 degree selected from commercially available barley broo concentration or sweet wine concentration is 22-28
Degree is preferred.
3. container closure, and stand 12 months at room temperature and more than.
4. extracting filtering using filter paper, suction filtration process is repeated 2 times acquisition clear filtrate as cordyceps militaris liquor.
Embodiment 4：Cordyceps sinensis N6- (2- ethoxys) adenosine is adjusting the application in being immunized for the instant of functional components
1 materials and methods
1.1 material
The cordyceps sinensis instant of Example 1, brownish-yellow powder, 2g/ bags of specification.Recommending consumption, 2 times a day for everyone, often
Secondary one bag, adult's body weight is calculated by 60kg, and it is 33.33mg/kg.bw to convert into dosage.3.1.2 experimental animal
Select healthy male ICR mouse, 18~22g；Purchased from Wenzhou Medical College's animal experimental center.Animal adapts to ring before experiment
Border at least 5d.Room temperature is maintained at 25 DEG C, ad lib and water inlet.The animal quality quality certification is numbered：SCXK (Zhejiang) 2010-0044.
2. method
2.1 experiment packet mouse are randomly divided into 5 groups：Separately set and recommended by experimental animal as human body in addition to control group, model group
Dosage 5,10,20 times as cordyceps sinensis instant low (166.65mg/kg), in (333.3mg/kg), high dose (666.6mg/
Kg) concentration group group, every group 10.Normal group and the daily sodium chloride injection of gavage 0.9% of model group, group is pressed by experimental group
Isometric instant is given, one time a day, continuous 15 days.From self administration of medication the 2nd day, in addition to control group, every mouse peritoneal injection
Endoxan 50mg/kg, continuous 7d prepare the mouse of immunologic hypofunction.
2.2 index determining
Determine immune organ quality：In last dose next day, put to death after mouse, weigh thymus gland and spleen, calculate mouse chest
Gland index and index and spleen index.Determined with macrophage phagocytosis dimethyl diaminophenazine chloride method and lift phagocyte phagocytic index.Determined with SRBC immunizations
Serum hemolysin.As a result interpretation of result is carried out using statistical software spss.16.0.
3. result
Influence of the 3.1 cordyceps sinensis instants to mouse thymus and spleen is shown in Table 1. from table 1, is compared with control group, mould
The thymus gland and index and spleen index of type group significantly reduce (p<0.05), cordyceps sinensis instant can improve hypoimmunity mice thymus gland and
Index and spleen index, has significant difference (p with model group ratio<0.05).
Influence of the cordyceps sinensis instant of table 1. to mouse thymus and spleen
Compared with model group, * P<0.05, * * P<0.01；Compared #P with control group<0.05.
Influence of the 3.2 cordyceps sinensis instants to mouse macrophage phagocytic index and serum hemolysin is shown in Table 2.Can by table 2
See：Compared with control group, the macrophage phagocytic index and serum hemolysin of model group significantly reduce (p<0.05), cordyceps sinensis is instant
Electuary can improve the macrophage phagocytic index and serum hemolysin of hypoimmunity mice, middle concentration and high concentration and model group
Than there is significant difference (p<0.05).
Influence of the cordyceps sinensis instant of table 2. to mouse macrophage phagocytic index and serum hemolysin
Compared with model group, * P<0.05, * * P<0.01；Compared #P with control group<0.05.
The content of N6- (2- ethoxys) adenosine in embodiment 5.HPLC detection cordyceps sinensis instants
1. chromatographic condition
Chromatographic column：Thermo C18Chromatographic column C18Post, 4.6mm × 150mm, 5 μm；Mobile phase is methanol：0.01mol/L phosphorus
Acid dihydride potassium solution=13：87；Flow velocity 1.0ml；Detection wavelength 257nm；25 DEG C of temperature；Sample size, 20 μ l
2. chromatographic results
2.1N6- (2- ethoxys) adenosine examination criteria curve
Detected according to above-mentioned chromatographic condition, N6- (2- ethoxys) adenosine chromatogram peak type is symmetrical, and retention time is abundant.Return
Equation is Y=51.668X-104.7, r=0.9993.Standard curve is shown in Fig. 4, shows N6- (2- ethoxys) adenosine is 20~125
In μ g ranges, good linear relationship is presented with sample size in peak area.The HPLC schematic diagrames of N6 dihydroxy ethyl adenosine standard specimens are shown in figure
5。
2.2 cordyceps sinensis N6 dihydroxy ethyls adenosines are the adenosine content of the electuary of functional components
Cordyceps sinensis instant adenosine content testing result is 6.39ug/ml.As shown in Figure 6.
Embodiment 6：Cordyceps sinensis functional components N6- (2- ethoxys) adenosines are on lymphopoietic influence
Experimental method：Lymphocyte early stage separating treatment：
The conventional separation of row after anticoagulant blood-collecting, surveying lymphocyte suspension concentration is：1*106/ml, per small lattice 10 or so, often
Individual aperture adds 50ul lymphocyte suspensions, adds the medicine polysaccharide 50ul of the various concentrations configured with serum-free 1640, each
6 holes are repeated, 2-10 is classified as the polysaccharide of various concentrations, and 11 be cell suspension control, and periphery is sealed up with 1640, is cultivated 47 hours, the phase
Between observation cytoactive and upgrowth situation.
As a result：By comparing, as N6- (2- ethoxys) adenosine final concentration of 500ug/ml, OD values are substantially less than cell pair
According to illustrating that the concentration may suppress the propagation of lymphocyte；When N6- (2- ethoxys) adenosine final concentration of 250,125,
During 62.5ug/ml, OD values are not significantly higher than or less than cell controls, when concentration be 15.6,7.8,3.9,1.9ug/ml when, OD values
It is significantly higher than cell controls, when illustrating the final concentration of 1.9-31.2 of N6- (2- ethoxys) adenosine, lymphocyte can be remarkably promoted
Propagation, has raising effect to immune.Fig. 7 is cordyceps sinensis functional components N6- (2- ethoxys) adenosine to lymphopoietic
Influence schematic diagram.
Claims (9)
1. a kind of cordyceps sinensis instant for adjusting immunologic function, it is characterised in that the cordyceps sinensis instant is with N6- (2- hydroxyl second
Base) adenosine is functional components, the preparation method of cordyceps sinensis instant is as follows：
1.1 dry cordyceps sinensis, jujube and matrimony vine to water content less than 5%, by weight ratio：10-60 parts of cordyceps sinensis, jujube 10-
40 parts, 10-30 parts of matrimony vine, cordyceps sinensis, jujube and matrimony vine are pulverized and sieved, and are added 10-30 times of pure water immersion 2h, are obtained raw material mixing
Liquid；The cordyceps sinensis is cordyceps sinensis, Periostracum cicadae, Cordyceps militaris and its fructification, mycelia, spore and training natural or manually cultivate
Support the one or more in residue culture medium；
1.2 pairs of raw material mixed liquors carry out ultrasonic extraction：25 DEG C are extracted 2 times, 35 minutes every time, after separation of solid and liquid, take supernatant to concentrate,
It is dried to obtain the Cordyceps of the N6- of functional components containing cordyceps sinensis (2- ethoxys) adenosine；
Cordyceps obtained by step 1.2 and Sucralose are put into mixing machine by 1.3 to be mixed, and the addition of Sucralose is
10-30 parts, quantitative package after oversized particles and powder, autoclaving is rejected in sieving.
2. cordyceps sinensis instant according to claim 1, it is characterised in that cordyceps sinensis in step 1.1, jujube and matrimony vine are matched somebody with somebody
Than for 20 parts of cordyceps sinensis, 20 parts of jujube, 30 parts of matrimony vine.
3. it is a kind of adjust immunologic function cordyceps sinensis tablet, it is characterised in that the cordyceps sinensis tablet using N6- (2- ethoxys) adenosines as
Functional components, the preparation method of cordyceps sinensis tablet is as follows：
1.1 dry cordyceps sinensis, jujube and matrimony vine to water content less than 5%, by weight ratio：10-60 parts of cordyceps sinensis, jujube 10-
40 parts, 10-30 parts of matrimony vine, cordyceps sinensis, jujube and matrimony vine are pulverized and sieved, and are added 10-30 times of pure water immersion 2h, are obtained raw material mixing
Liquid；The cordyceps sinensis is cordyceps sinensis, Periostracum cicadae, Cordyceps militaris and its fructification, mycelia, spore and training natural or manually cultivate
Support the one or more in residue culture medium；
1.2 pairs of raw material mixed liquors carry out ultrasonic extraction：25 DEG C are extracted 2 times, 35 minutes every time, after separation of solid and liquid, take supernatant to concentrate,
It is dried to obtain the Cordyceps of the N6- of functional components containing cordyceps sinensis (2- ethoxys) adenosine；
1.3 add microcrystalline cellulose, Sucralose and citric acid into the Cordyceps obtained by step 1.2, after being well mixed
Wet grain is made；Wherein Cordyceps 62-88 parts, 1-5 parts of microcrystalline cellulose, 10-30 parts of Sucralose, 1-3 parts of citric acid；
1.4 to dry wet grain obtained by step 1.3 to moisture at 65 DEG C be 2~3%, 20 eye mesh screen whole grains is crossed, in drying
The magnesium stearate for adding 0.5-2 parts in particle makees lubricant, is obtained after mixing through tabletting machine containing the extraction of cordyceps sinensis feature
The cordyceps sinensis tablet of thing；
Quality inspection, packaging after 1.5 autoclavings.
4. cordyceps sinensis tablet according to claim 3, it is characterised in that the proportioning of cordyceps sinensis, jujube and matrimony vine is in step 1.1
20 parts of cordyceps sinensis, 20 parts of jujube, 30 parts of matrimony vine.
5. a kind of cordyceps militaris liquor for adjusting immunologic function, it is characterised in that the cordyceps militaris liquor is using N6- (2- ethoxys) adenosine as function
Property composition, the preparation method of cordyceps militaris liquor is as follows：
1.1 dry cordyceps sinensis, jujube and matrimony vine to water content less than 5%, by weight ratio：10-60 parts of cordyceps sinensis, jujube 10-
40 parts, 10-30 parts of matrimony vine, cordyceps sinensis, jujube and matrimony vine are pulverized and sieved, and are added 10-30 times of pure water immersion 2h, are obtained raw material mixing
Liquid；The cordyceps sinensis is cordyceps sinensis, Periostracum cicadae, Cordyceps militaris and its fructification, mycelia, spore and training natural or manually cultivate
Support the one or more in residue culture medium；
1.2 pairs of raw material mixed liquors carry out ultrasonic extraction：25 DEG C are extracted 2 times, 35 minutes every time, after separation of solid and liquid, take supernatant to concentrate,
It is dried to obtain the Cordyceps of the N6- of functional components containing cordyceps sinensis (2- ethoxys) adenosine；
1.3 are allocated in the following proportions using the Cordyceps obtained by step 1.2 as raw material with beverage wine：
Beverage wine 93-98 parts by weight
Cordyceps 2-7 parts by weight
1.4 are well mixed in a reservoir；
1.5 container closures, and stand more than 12 months at room temperature；
1.6 obtain clear filtrate as cordyceps militaris liquor through double filtration.
6. cordyceps militaris liquor according to claim 5, it is characterised in that the proportioning of cordyceps sinensis, jujube and matrimony vine is worm in step 1.1
20 parts of grass, 20 parts of jujube, 30 parts of matrimony vine.
7. cordyceps militaris liquor according to claim 5, it is characterised in that the proportioning of Cordyceps and beverage wine in step 1.3
For：Beverage wine is 95~97.5 parts, 2.5~5 parts of Cordyceps.
8. cordyceps militaris liquor according to claim 5, it is characterised in that described beverage wine is selected from the white wine or 12- of 42-65 degree
28 degree of yellow rice wine.
9. cordyceps militaris liquor according to claim 5, it is characterised in that described beverage wine is selected from the white wine or 22- of 48-52 degree
28 degree of yellow rice wine.
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| CN110760421A (en) * | 2018-07-26 | 2020-02-07 | 浙江泛亚生物医药股份有限公司 | Cordyceps cicadae health wine and preparation method thereof |
| CN116870083A (en) * | 2023-07-06 | 2023-10-13 | 南京伍膳生物科技有限公司 | Cordyceps cicadae powder for enhancing immunity and improving kidney function and preparation method thereof |
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| CN116870083A (en) * | 2023-07-06 | 2023-10-13 | 南京伍膳生物科技有限公司 | Cordyceps cicadae powder for enhancing immunity and improving kidney function and preparation method thereof |
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