CN116870083A - Cordyceps cicadae powder for enhancing immunity and improving kidney function and preparation method thereof - Google Patents
Cordyceps cicadae powder for enhancing immunity and improving kidney function and preparation method thereof Download PDFInfo
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Abstract
The application discloses cordyceps cicadae powder for enhancing immunity and improving kidney function and a preparation method thereof, belonging to the technical field of health care products. The cordyceps cicadae powder for enhancing immunity and improving kidney function disclosed by the application comprises the following raw materials in parts by weight: 15-40 parts of cordyceps cicadae extractive powder, 2-8 parts of black beans, 2-8 parts of bighead atractylodes rhizome, 1-5 parts of Chinese yam, 0.5-1.5 parts of medlar, 20-30 parts of rhizoma corydalis decumbentis, 5-10 parts of red dates and 1-3 parts of citric acid. The Cordyceps cicadae composition can effectively improve kidney function, improve immunity of human body, and cause no drug resistance.
Description
Technical Field
The application belongs to the technical field of health products, and in particular relates to cordyceps cicadae powder for enhancing immunity and improving renal function and a preparation method thereof.
Background
Cordyceps cicadae (Cordyceps cicadae) is one of the most valuable traditional Chinese medicines, and is an entomogenous fungus complex formed by entomogenous fungi parasitic on cicada nymphs. Cordyceps cicadae contains various bioactive components including cordycepin, N- (2-hydroxyethyl) adenosine, cordycepic acid, polysaccharides, ergosterol, etc. The polysaccharide is one of the active ingredients with the highest content in the cordyceps sobolifera, and has various effects of improving immunity, reducing blood sugar, resisting tumor, protecting kidney, resisting oxidation, resisting aging and the like. With the improvement of health care consciousness of people, the understanding of the cordyceps sobolifera is deeper.
Along with the progress of society, bring convenience for people and simultaneously bring a plurality of influences, such as acceleration of life rhythm, unbalance of dietary structure, increase of life pressure and the like, so that the organism is in overdraft state for a long time, and sub-health phenomena such as endocrine dyscrasia, neurasthenia, insomnia and the like are easily caused. For example, nephritis and kidney stones, are a type of juvenile, multiple kidney disease, and often chronic kidney stones are not effectively treated to induce nephritis. The cordyceps sobolifera has the similar components as the cordyceps sobolifera and has the effects of tonifying kidney and lung and strengthening spleen and tonifying deficiency similar to the cordyceps sobolifera, so that the cordyceps sobolifera is often used for developing various health-care medicaments or dual-purpose resources of medicine and food in modern medicine. However, cordyceps cicadae is used as a rare traditional Chinese medicine, and the exertion degree of the efficacy of cordyceps cicadae should be fully considered in the adding process so as to improve the utilization rate of the rare medicine.
Disclosure of Invention
The application provides cordyceps cicadae powder for enhancing immunity and improving kidney function and a preparation method thereof, which are used for solving the problems of low development degree, low drug effect and the like of cordyceps cicadae in the prior art.
In a first aspect, the application provides cordyceps cicadae powder for enhancing immunity and improving renal function, which comprises the following raw materials in parts by weight: 15-40 parts of cordyceps cicadae extractive powder, 2-8 parts of black beans, 2-8 parts of bighead atractylodes rhizome, 1-5 parts of Chinese yam, 0.5-1.5 parts of medlar, 20-30 parts of rhizoma corydalis decumbentis, 5-10 parts of red dates and 1-3 parts of citric acid.
Further, the material comprises the following raw materials in parts by weight: 20-30 parts of cordyceps cicadae extractive powder, 3-6 parts of black beans, 3-6 parts of bighead atractylodes rhizome, 2-4 parts of Chinese yam, 0.8-1.2 parts of medlar, 20-25 parts of rhizoma corydalis decumbentis, 5-8 parts of red dates and 1.8-2 parts of citric acid.
Further, the material comprises the following raw materials in parts by weight: 25 parts of cordyceps cicadae extractive powder, 5 parts of black beans, 5 parts of bighead atractylodes rhizome, 3 parts of Chinese yam, 1 part of medlar, 20 parts of rhizoma corydalis decumbentis, 5 parts of red dates and 2 parts of citric acid.
Further, the cordyceps sobolifera extract powder comprises cordyceps sobolifera original powder and cordyceps sobolifera spore powder which are extracted according to the mass ratio of 80-95:5-20.
Further, the cordyceps cicadae original powder is prepared by crushing cordyceps cicadae plants into fine powder which is sieved by a 20-50-mesh sieve.
Atractylodis rhizoma belongs to perennial herb of Atractylodes of Compositae, and is used as rhizome. Bitter and sweet in flavor, warm in nature. Enter spleen and stomach meridians. The bighead atractylodes rhizome has the effects of strengthening spleen and supplementing qi, drying dampness and promoting diuresis, stopping sweating and preventing miscarriage, and is used for spleen deficiency and anorexia, abdominal distention and diarrhea, phlegm retention and palpitation, edema, spontaneous sweat and fetal movement disturbance.
Fructus Jujubae is mature fruit of Rhamnaceae deciduous shrub or small arbor plant, has sweet taste, and is warm, and enters spleen and stomach channels. The red dates can tonify middle-jiao and qi, nourish blood and tranquilize, treat weakness of spleen and stomach, loose stool, lassitude and debilitation, deficiency of qi and blood, palpitation, allergic purpura and dysphoria of women, and can alleviate toxicity of drastic drugs and reduce side effects.
Black beans mainly contain unsaturated fatty acid, have an absorptivity of up to 95%, and not only meet the needs of human body on fat, but also have the effect of reducing cholesterol in blood; the black beans contain rich vitamins, egg yolk, melanin and other substances, wherein the B vitamins and vitamin E are very high in content, and the black beans have the effects of nutrition and health care, and also contain rich microelements, so that the black beans are necessary for keeping the functions of the body intact, delaying the aging of the body, reducing the blood viscosity and meeting the requirements of the brain on the microelements. The black bean carried by the medicine of the compendium of materia medica has the efficacies of tonifying kidney, nourishing blood, clearing heat and detoxicating, promoting blood circulation by removing blood stasis, blackening the eyes and prolonging life. "
Chinese yam mainly has the functions of strengthening spleen, tonifying lung, reinforcing kidney and tonifying essence; treating diarrhea due to spleen deficiency, chronic dysentery, cough due to asthenia, diabetes, spermatorrhea, leukorrhagia, and frequent micturition; spleen and stomach tonifying, body fluid generating, lung nourishing, kidney tonifying and seminal emission astringing. The Chinese yam is rich in various amino acids and polysaccharides, and the 'materia medica schema' carries: tonifying kidney-qi, strengthening spleen and stomach, stopping diarrhea, resolving phlegm and saliva, and moistening skin and hair.
Wolfberry fruit, it is neutral and sweet; it enters liver, kidney and lung meridians. The wolfberry contains rich betaine, wolfberry polysaccharide, wolfberry pigment, henbane amine and other components, and the wolfberry polysaccharide has the functions of promoting immunity, resisting senility, resisting tumor, eliminating free radical, protecting reproductive function, etc. and the betaine, wolfberry pigment, etc. have the functions of raising immunity.
Rhizoma corydalis Decumbentis, bitter in nature, pungent in flavor, warm in nature, and enters liver meridian, and has the effects of activating blood and collaterals, promoting qi circulation and relieving pain, dispelling wind and removing dampness. Rhizoma corydalis Decumbentis contains various alkaloid components mainly acting on circulatory system and nervous system.
Cordyceps cicadae can effectively improve kidney function, reduce blood creatinine and urea nitrogen levels, improve creatinine clearance rate, and delay the progress of chronic kidney disease. Can also improve anemia of chronic kidney disease patients, increase plasma albumin level, and reduce serum cholesterol level.
In a second aspect, the application provides a preparation method of cordyceps cicadae powder for enhancing immunity and improving renal function, which comprises the following steps:
extracting cordyceps cicadae powder by adopting an alcohol precipitation water extraction method to obtain cordyceps cicadae extract powder;
uniformly mixing the black beans, the bighead atractylodes rhizome, the Chinese yam, the medlar, the rhizoma corydalis decumbentis and the red dates, and grinding to obtain medicinal powder;
mixing the medicinal powder with water, soaking, decocting, and filtering to obtain first residue and first medicinal liquid;
mixing the first medicine residues with water, decocting, filtering to obtain second medicine residues and second medicine liquid, and mixing the first medicine liquid and the second medicine liquid to obtain a medicine liquid mixture;
and (3) uniformly stirring the cordyceps cicadae extract powder and the liquid medicine mixture, adding citric acid, continuously stirring, and sequentially concentrating, drying, crushing and granulating.
Further, the alcohol precipitation water extraction method specifically comprises the following steps:
weighing Cordyceps cicadae plant and Cordyceps cicadae spore powder according to a certain proportion, pulverizing Cordyceps cicadae plant into powder, and mixing with Cordyceps cicadae spore powder uniformly;
adding water into the uniformly mixed powder, carrying out reflux extraction at an extraction temperature of 50-90 ℃, and centrifuging to obtain a supernatant;
adding 2-10 times of ethanol into the supernatant, standing for 24-48 hours at the temperature of 4-5 ℃, centrifuging, and taking out the precipitate to obtain cordyceps cicadae extract powder.
Further, the extraction time of reflux extraction is 2-4 h, the extraction times are 1-5 times, and the feed-liquid ratio is 1:30-70.
Further, the powder particle size of the powder is 1-5 mm, the mass ratio of the crushed powder (namely the powder) to water is 1:5-10, the soaking time is 30-60 min, and the decocting time is 30-60 min.
Further, the mixing mass ratio of the first medicine residues to the water is 1:2-5, and the decoction time is 30-60 min.
Compared with the prior art, the technical scheme provided by the embodiment of the application has at least the following advantages:
1. according to the application, various conventional raw materials are compatible with the precious medicinal material cordyceps cicadae, so that the addition of cordyceps cicadae can be reduced, the kidney function is remarkably improved on the basis of not reducing the original effects of the cordyceps cicadae, such as dispelling wind and heat, stopping bleeding and resolving phlegm, resisting fatigue, resisting stress, resisting aging, resisting tumor, improving hypnosis and the like, and the sub-health state of a human body is further improved by improving the immunity of the human body.
2. In the application, cordyceps cicadae is taken as a main agent, so that the effects of nourishing spleen and stomach, restoring spleen, ascending clear and descending turbid are achieved, and kidney is helped to seal and gasify; rhizoma corydalis Decumbentis, rhizoma Atractylodis Macrocephalae and rhizoma Dioscoreae are used as ministerial drugs to improve pathological damage of renal tubular stroma and inhibit CRF (chronic renal failure) micro-inflammatory state, thereby preventing and treating renal stroma fibrosis and improving renal function; the medlar, the red dates and the black beans are taken as adjuvant drugs, so that the sleeping can be improved, lipid peroxidation and protein oxidation can be inhibited, and the inactivation of proteins containing sulfur can be prevented; and finally, promoting various proteins in the raw materials to react through citric acid to form a more stable protein cross-linked structure, so that the stability and the service life of the composition are improved. The traditional Chinese medicine composition disclosed by the application has the effects of tonifying spleen and kidney, activating blood and dissolving turbidity by combining the medicines, can effectively treat chronic nephritis, improves the immunity of a human body, has no toxic or side effect and does not cause drug resistance.
3. According to the application, an alcohol precipitation water extraction method is adopted for extracting the cordyceps cicadae active ingredient, and the extraction rate and the activity of the active ingredient can be improved through specific extraction temperature, extraction time, extraction times and water-liquid ratio; the extracted active ingredients and the active ingredients of the rest raw materials are fully mixed, and then the prepared particles are very easy to be absorbed by human bodies so as to exert the efficacy, and the prepared composition successfully improves the efficacy due to the high concentration of the concentrated composition and the compatibility effect between medicines, so that the efficacy of the raw materials can be achieved by using a small amount of the composition, and the precious cordyceps cicadae resources are fully utilized.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present application more apparent, the technical solutions in the embodiments of the present application will be clearly and completely described in the following in conjunction with the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Unless otherwise specifically indicated, the various raw materials, reagents, instruments, equipment and the like used in the present application are commercially available or may be prepared by existing methods.
In a first aspect, the application provides cordyceps cicadae powder for enhancing immunity and improving renal function, which comprises the following raw materials in parts by weight: 15-40 parts of cordyceps cicadae extractive powder, 2-8 parts of black beans, 2-8 parts of bighead atractylodes rhizome, 1-5 parts of Chinese yam, 0.5-1.5 parts of medlar, 20-30 parts of rhizoma corydalis decumbentis, 5-10 parts of red dates and 1-3 parts of citric acid.
The cordyceps cicadae powder for enhancing immunity and improving kidney function provided by the embodiment of the application adopts the monarch, minister and assistant effects of traditional Chinese medicines, plays the roles of improving the utilization rate and the efficacy of cordyceps cicadae, and has the advantages of lower usage amount, better effect of enhancing immunity, good effect of enhancing kidney function and no toxic or side effect. Specifically, the cordyceps cicadae powder for enhancing immunity and improving kidney function is matched with modern western medicines on the basis of the traditional Chinese medicine theory, takes cordyceps cicadae as a main medicine, and aims at chronic kidney dysfunction or nephritis patients to inhibit the expression of kidney tissues NF- κB (nuclear factor κB protein), MCP-1 (protein secreted by astrocytes and promoting inflammation) and TNF-alpha (tumor necrosis factor alpha), lighten kidney inflammatory reaction, further resist renal interstitial fibrosis caused by inflammatory factors and play a role in delaying the progression of chronic kidney diseases. Rhizoma corydalis Decumbentis, rhizoma Atractylodis Macrocephalae and rhizoma Dioscoreae are used as ministerial drugs to improve pathological damage of renal tubular stroma and inhibit CRF micro-inflammatory state, thereby preventing and treating renal stroma fibrosis and improving renal function; the medlar, the red dates and the black beans are taken as adjuvant drugs, so that the sleeping can be improved, lipid peroxidation and protein oxidation can be inhibited, the inactivation of proteins containing sulfur can be prevented, the blood pressure can be reduced, the excretion of urine protein can be reduced, the plasma albumin can be increased, and the progress of CRF disease can be delayed; and finally, promoting various proteins in the raw materials to react through citric acid to form a more stable protein cross-linked structure, so that the stability and the service life of the composition are improved. The medicines are combined for simultaneous application of attack and nourishment, and play a role in strengthening spleen and kidney, activating blood and dissolving turbidity. And other commonly used medicines are adopted to be compatible with cordyceps sobolifera, so that the use amount of cordyceps sobolifera can be reduced, the efficacy of cordyceps sobolifera can not be reduced, and the cost of the medicines can be effectively reduced.
In some specific embodiments, the citric acid, cordyceps cicadae, medlar, rhizoma corydalis decumbentis, red dates, black beans, chinese yam and bighead atractylodes rhizome adopted by the application can be prepared by directly adopting a commercially available product or adopting a preparation method recorded in Chinese pharmacopoeia.
The cordyceps cicadae extract powder can be 15 parts, 16 parts, 20 parts, 25 parts, 27 parts, 28 parts, 30 parts, 32 parts, 35 parts, 40 parts and the like, preferably 25 parts, by weight.
In some specific embodiments, the black beans may be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, or 8 parts, preferably 5 parts, by weight of the raw materials.
In some specific embodiments, the bighead atractylodes rhizome may be 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts or 8 parts, preferably 5 parts, by weight of the raw materials, and the same amount of bighead atractylodes rhizome and black beans is preferred.
In some specific embodiments, the yam may be 1 part, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 5 parts, etc., preferably 3 parts, by weight of the raw material.
In some specific embodiments, the wolfberry may be 0.5 parts, 0.75 parts, 1 part, 1.25 parts, or 1.5 parts, preferably 1 part, by weight of the starting material.
In some specific embodiments, the decumbent corydalis tuber may be 20 parts, 22 parts, 24.5 parts, 25 parts, 27 parts, 28 parts, 30 parts, etc., preferably 25 parts, by weight of the raw materials.
In some specific embodiments, the red date may be 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts, preferably 5 parts, by weight of the raw materials, and preferably the same amount of white atractylodes rhizome, red date and black beans is used.
In some specific embodiments, the citric acid may be 1 part, 1.2 parts, 1.5 parts, 1.8 parts, 2.0 parts, 2.5 parts, or 3 parts, preferably 2 parts, by weight of the starting material.
Preferably, cordyceps cicadae powder for enhancing immunity and improving kidney function comprises the following raw materials in parts by weight: 20-30 parts of cordyceps cicadae extractive powder, 3-6 parts of black beans, 3-6 parts of bighead atractylodes rhizome, 2-4 parts of Chinese yam, 0.8-1.2 parts of medlar, 20-25 parts of rhizoma corydalis decumbentis, 5-8 parts of red dates and 1.8-2 parts of citric acid.
More preferably, cordyceps cicadae powder for enhancing immunity and improving kidney function comprises the following raw materials in parts by weight: 25 parts of cordyceps cicadae extractive powder, 5 parts of black beans, 5 parts of bighead atractylodes rhizome, 3 parts of Chinese yam, 1 part of medlar, 20 parts of rhizoma corydalis decumbentis, 5 parts of red dates and 2 parts of citric acid.
As one mode of the embodiment of the application, the cordyceps sobolifera extract powder comprises cordyceps sobolifera original powder and cordyceps sobolifera spore powder in a mass ratio of 80-95:5-20. Wherein the cordyceps cicadae original powder is prepared by pulverizing cordyceps cicadae plants into fine powder which is sieved by a 20-50-mesh sieve.
Preferably, the cordyceps sobolifera extract powder comprises cordyceps sobolifera raw powder and cordyceps sobolifera spore powder in a mass ratio of 80:20, wherein the cordyceps sobolifera raw powder is prepared by crushing cordyceps sobolifera plants into fine powder which is sieved by a 50-mesh sieve.
The inventor of the application discovers that when the mass ratio of cordyceps sobolifera raw powder to cordyceps sobolifera spore powder is controlled to be 80:20, the utilization rate of cordyceps sobolifera can be improved, and the waste of cordyceps sobolifera resources can be reduced.
In a second aspect, based on a general inventive concept, the present application provides a method for preparing cordyceps sobolifera powder for enhancing immunity and improving renal function according to any one of the first aspect, comprising the steps of:
s1, weighing raw materials according to parts by weight, extracting active ingredients in cordyceps sobolifera through an alcohol precipitation water extraction mode, and preparing cordyceps sobolifera extract powder for later use;
s2, uniformly mixing black beans, bighead atractylodes rhizome, chinese yam, medlar, rhizoma corydalis decumbentis and red dates, and grinding into powder for later use;
s3, mixing the powder obtained by crushing the S2 with water, soaking, decocting, and filtering to obtain first residues and first liquid medicine;
s4, mixing the first medicine residues with water, decocting, filtering to obtain second medicine residues and second medicine liquid, and mixing the first medicine liquid and the second medicine liquid to obtain a medicine liquid mixture;
s5, uniformly stirring the cordyceps sobolifera extract powder obtained in the step 1 and the liquid medicine mixture obtained in the step 4, adding citric acid, continuously stirring, and sequentially concentrating, drying, crushing and granulating to obtain cordyceps sobolifera powder for enhancing immunity and improving kidney function.
The embodiment of the application provides a preparation method of cordyceps cicadae powder for enhancing immunity and improving kidney functions, which fully extracts active ingredients in cordyceps cicadae, such as cordyceps cicadae polysaccharide and amino acid, through an alcohol precipitation and water extraction method, controls the loss of the active ingredients through specific parameters, and improves the extraction rate and further the concentration of the active ingredients in the extract; the extracted active ingredients and the active ingredients of the rest raw materials are combined to prepare the preparation, so that the preparation can be directly eaten, and the absorption of cordyceps sobolifera is facilitated. Compared with the cordyceps cicadae raw material, the cordyceps cicadae has the same pharmacological effect, but the dosage is lower, and the drug effect is better.
The preparation method provided by the application uses the conventional instrument, has the advantages of simple operation and high repeatability, does not need extra specific equipment, and is suitable for industrial production. Meanwhile, the preparation method of cordyceps cicadae powder for enhancing immunity and improving kidney function is realized based on the cordyceps cicadae powder for enhancing immunity and improving kidney function in any one of the first aspect, so that the cordyceps cicadae powder at least has all the beneficial effects brought by the technical scheme of the embodiment and is not repeated here.
In some specific embodiments, the method of mixing is mechanical mixing or ultrasonic mixing, among other means of agitation and mixing conventional in the art.
As an implementation mode of the embodiment of the application, the steps of extracting the effective components in the cordyceps sobolifera by the way of alcohol precipitation and water extraction to prepare the cordyceps sobolifera extract powder comprise:
s1.1, weighing cordyceps sobolifera plants and cordyceps sobolifera spore powder according to a proportion, crushing cordyceps sobolifera plants into powder, and uniformly mixing with cordyceps sobolifera spore powder;
s1.2, adding water into the uniformly mixed powder, carrying out reflux extraction at an extraction temperature of 50-90 ℃, and centrifuging to obtain a supernatant;
s1.3, adding ethanol with the volume of 2-10 times into the supernatant, standing for 24-48 hours at the temperature of 4-5 ℃, centrifuging, and taking the precipitate to obtain the extract.
Wherein, the extraction time in the step S1.2 is 2-4 h, the extraction times are 1-5 times, and the feed-liquid ratio is 1:30-70.
In some alternative embodiments, the particle size of the powder after crushing in step S3 is 1-5 mm, the mass ratio of the crushed powder to water is 1:5-10, preferably 1:8, the soaking time is 30-60 min, the decocting time is 30-60 min, preferably the soaking time is 60min, and the decocting time is 45min.
In some alternative embodiments, the mixing mass ratio of the first residue to water in step S4 is 1:2-5, preferably 1:5, and the time of decocting is 30-60 min, preferably 60min.
The concentration and drying in the present application are not limited to specific parameters, and may be performed mainly by solid granulation, and for example, concentration to a relative density of 1.0 to 1.5 is performed.
The principles and features of the present application are described below in connection with the following examples, which are set forth to illustrate, but are not to be construed as limiting the scope of the application. The specific conditions are not noted in the examples and are carried out according to conventional conditions or conditions recommended by the manufacturer. The reagents or apparatus used were conventional products commercially available without the manufacturer's attention.
Example 1
The embodiment provides cordyceps cicadae powder for enhancing immunity and improving renal function, which comprises the following raw materials in parts by weight: 25 parts of cordyceps cicadae extractive powder, 5 parts of black beans, 5 parts of bighead atractylodes rhizome, 3 parts of Chinese yam, 1 part of medlar, 20 parts of rhizoma corydalis decumbentis, 5 parts of red dates and 2 parts of citric acid.
In the embodiment, the cordyceps sobolifera extracting powder comprises cordyceps sobolifera raw powder and cordyceps sobolifera spore powder in a mass ratio of 80:20.
In the embodiment, the cordyceps cicadae and cordyceps sinensis original powder is prepared by crushing cordyceps cicadae plants into fine powder which is sieved by a 50-mesh sieve.
The embodiment also provides a preparation method of the cordyceps cicadae powder for enhancing immunity and improving renal function, which comprises the following steps:
(1) Weighing Cordyceps cicadae plant and Cordyceps cicadae spore powder according to a certain proportion, pulverizing Cordyceps cicadae plant into powder, and mixing with Cordyceps cicadae spore powder uniformly;
adding water into the uniformly mixed powder, controlling the ratio of feed to liquid to be 1:70, carrying out reflux extraction at the extraction temperature of 60 ℃ for 2 times, extracting for 3 hours each time, and centrifuging to obtain supernatant;
adding 10 times of ethanol into the supernatant, standing at 4deg.C for 24 hr, centrifuging, and collecting precipitate to obtain Cordyceps cicadae extractive powder;
(2) Uniformly mixing black beans, bighead atractylodes rhizome, chinese yam, medlar, rhizoma corydalis decumbentis and red dates, and grinding into 5mm powder for later use;
(3) Mixing the crushed powder in the step (2) with water according to a mass ratio of 1:10, soaking for 60min, decocting for 45min, and filtering to obtain first residues and first liquid medicine;
(4) Mixing the first medicine residues with water according to a mass ratio of 1:5, decocting for 60min, filtering to obtain second medicine residues and second medicine liquid, and mixing the first medicine liquid and the second medicine liquid to obtain a medicine liquid mixture;
(5) Stirring the cordyceps sobolifera extract powder obtained in the step (1) and the liquid medicine mixture obtained in the step (4) uniformly, adding citric acid, continuously stirring, concentrating (concentrating to a relative density of 1.25), drying, crushing and granulating in sequence, and obtaining the cordyceps sobolifera powder for enhancing immunity and improving renal function.
Example 2
The embodiment provides cordyceps cicadae powder for enhancing immunity and improving renal function, which comprises the following raw materials in parts by weight:
15 parts of cordyceps cicadae extractive powder, 2 parts of black beans, 2 parts of bighead atractylodes rhizome, 1 part of Chinese yam, 0.5 part of medlar, 20 parts of corydalis decumbens, 5 parts of red dates and 1 part of citric acid.
In the embodiment, the cordyceps sobolifera extracting powder comprises cordyceps sobolifera raw powder and cordyceps sobolifera spore powder in a mass ratio of 80:20.
In the embodiment, the cordyceps cicadae and cordyceps sinensis original powder is prepared by crushing cordyceps cicadae plants into fine powder which is sieved by a 50-mesh sieve.
The preparation method in this embodiment is as in embodiment 1, and is not described here again.
Example 3
The embodiment provides cordyceps cicadae powder for enhancing immunity and improving renal function, which comprises the following raw materials in parts by weight: 40 parts of cordyceps cicadae extractive powder, 8 parts of black beans, 8 parts of bighead atractylodes rhizome, 5 parts of Chinese yam, 1.5 parts of medlar, 30 parts of corydalis decumbens, 10 parts of red dates and 3 parts of citric acid.
In the embodiment, the cordyceps sobolifera extracting powder comprises cordyceps sobolifera raw powder and cordyceps sobolifera spore powder in a mass ratio of 80:20.
In the embodiment, the cordyceps cicadae and cordyceps sinensis original powder is prepared by crushing cordyceps cicadae plants into fine powder which is sieved by a 50-mesh sieve.
The preparation method in this embodiment is as in embodiment 1, and is not described here again.
Example 4
The embodiment provides cordyceps cicadae powder for enhancing immunity and improving renal function, which comprises the following raw materials in parts by weight: 20 parts of cordyceps cicadae extractive powder, 3 parts of black beans, 3 parts of bighead atractylodes rhizome, 2 parts of Chinese yam, 0.8 part of medlar, 20 parts of corydalis decumbens, 5 parts of red dates and 1.8 parts of citric acid.
In the embodiment, the cordyceps sobolifera extracting powder comprises cordyceps sobolifera raw powder and cordyceps sobolifera spore powder in a mass ratio of 95:5.
In the embodiment, the cordyceps cicadae and cordyceps sinensis original powder is prepared by crushing cordyceps cicadae plants into fine powder which is sieved by a 20-mesh sieve.
The preparation method in this embodiment is as in embodiment 1, and is not described here again.
Example 5
The embodiment provides cordyceps cicadae powder for enhancing immunity and improving renal function, which comprises the following raw materials in parts by weight: 30 parts of cordyceps cicadae extractive powder, 6 parts of black beans, 6 parts of bighead atractylodes rhizome, 4 parts of Chinese yam, 4 parts of medlar, 25 parts of rhizoma corydalis decumbentis, 8 parts of red dates and 1.8 parts of citric acid.
In the embodiment, the cordyceps sobolifera extracting powder comprises cordyceps sobolifera raw powder and cordyceps sobolifera spore powder in a mass ratio of 85:15.
In the embodiment, the cordyceps cicadae and cordyceps sinensis original powder is prepared by crushing cordyceps cicadae plants into fine powder which is sieved by a 30-mesh sieve.
The preparation method in this embodiment is as in embodiment 1, and is not described here again.
Example 6
The embodiment provides cordyceps cicadae powder for enhancing immunity and improving kidney function, which comprises the following raw materials in proportion as in embodiment 1:
(1) Weighing Cordyceps cicadae plant and Cordyceps cicadae spore powder according to a certain proportion, pulverizing Cordyceps cicadae plant into powder, and mixing with Cordyceps cicadae spore powder uniformly;
adding water into the uniformly mixed powder, controlling the ratio of feed to liquid to be 1:30, carrying out reflux extraction at the extraction temperature of 60 ℃ for 3 times, extracting for 3 hours each time, and centrifuging to obtain supernatant;
adding 10 times of ethanol into the supernatant, standing at 4deg.C for 24 hr, centrifuging, and collecting precipitate to obtain Cordyceps cicadae extractive powder;
(2) Uniformly mixing black beans, bighead atractylodes rhizome, chinese yam, medlar, rhizoma corydalis decumbentis and red dates, and grinding into 5mm powder for later use;
(3) Mixing the crushed powder in the step (2) with water according to a mass ratio of 1:10, soaking for 60min, decocting for 45min, and filtering to obtain first residues and first liquid medicine;
(4) Mixing the first medicine residues with water according to a mass ratio of 1:5, decocting for 60min, filtering to obtain second medicine residues and second medicine liquid, and mixing the first medicine liquid and the second medicine liquid to obtain a medicine liquid mixture;
(5) Stirring the cordyceps sobolifera extract powder obtained in the step (1) and the liquid medicine mixture obtained in the step (4) uniformly, adding citric acid, continuously stirring, concentrating (concentrating to a relative density of 1.30), drying, crushing and granulating in sequence, and obtaining the cordyceps sobolifera powder for enhancing immunity and improving renal function.
Example 7
The embodiment provides cordyceps cicadae powder for enhancing immunity and improving kidney function, which comprises the following raw materials in proportion as in embodiment 1:
(1) Weighing Cordyceps cicadae plant and Cordyceps cicadae spore powder according to a certain proportion, pulverizing Cordyceps cicadae plant into powder, and mixing with Cordyceps cicadae spore powder uniformly;
adding water into the uniformly mixed powder, controlling the ratio of feed to liquid to be 1:50, carrying out reflux extraction at the extraction temperature of 60 ℃ for 5 times, extracting for 3 hours each time, and centrifuging to obtain supernatant;
adding 10 times of ethanol into the supernatant, standing at 4deg.C for 24 hr, centrifuging, and collecting precipitate to obtain Cordyceps cicadae extractive powder;
(2) Uniformly mixing black beans, bighead atractylodes rhizome, chinese yam, medlar, rhizoma corydalis decumbentis and red dates, and grinding into 5mm powder for later use;
(3) Mixing the crushed powder in the step (2) with water according to a mass ratio of 1:10, soaking for 60min, decocting for 45min, and filtering to obtain first residues and first liquid medicine;
(4) Mixing the first medicine residues with water according to a mass ratio of 1:5, decocting for 60min, filtering to obtain second medicine residues and second medicine liquid, and mixing the first medicine liquid and the second medicine liquid to obtain a medicine liquid mixture;
(5) Stirring the cordyceps sobolifera extract powder obtained in the step (1) and the liquid medicine mixture obtained in the step (4) uniformly, adding citric acid, continuously stirring, concentrating (concentrating to a relative density of 1.25), drying, crushing and granulating in sequence, and obtaining the cordyceps sobolifera powder for enhancing immunity and improving renal function.
Example 8
The embodiment provides cordyceps cicadae powder for enhancing immunity and improving kidney function, which comprises the following raw materials in proportion as in embodiment 1:
(1) Weighing Cordyceps cicadae plant and Cordyceps cicadae spore powder according to a certain proportion, pulverizing Cordyceps cicadae plant into powder, and mixing with Cordyceps cicadae spore powder uniformly;
adding water into the uniformly mixed powder, controlling the ratio of feed to liquid to be 1:70, carrying out reflux extraction at the extraction temperature of 60 ℃ for 2 times, extracting for 3 hours each time, and centrifuging to obtain supernatant;
adding 8 times of ethanol into the supernatant, standing at 4deg.C for 30 hr, centrifuging, and collecting precipitate to obtain Cordyceps cicadae extractive powder;
(2) Uniformly mixing black beans, bighead atractylodes rhizome, chinese yam, medlar, rhizoma corydalis decumbentis and red dates, and grinding into 5mm powder for later use;
(3) Mixing the crushed powder in the step (2) with water according to a mass ratio of 1:5, soaking for 60min, decocting for 45min, and filtering to obtain first residues and first liquid medicine;
(4) Mixing the first medicine residues with water according to a mass ratio of 1:2.5, decocting for 60min, filtering to obtain second medicine residues and second medicine liquid, and mixing the first medicine liquid and the second medicine liquid to obtain a medicine liquid mixture;
(5) Stirring the cordyceps sobolifera extract powder obtained in the step (1) and the liquid medicine mixture obtained in the step (4) uniformly, adding citric acid, continuously stirring, concentrating (concentrating to a relative density of 1.3), drying, crushing and granulating in sequence, and obtaining the cordyceps sobolifera powder for enhancing immunity and improving renal function.
Example 9
The embodiment provides cordyceps cicadae powder for enhancing immunity and improving kidney function, which comprises the following raw materials in proportion as in embodiment 1:
(1) Weighing Cordyceps cicadae plant and Cordyceps cicadae spore powder according to a certain proportion, pulverizing Cordyceps cicadae plant into powder, and mixing with Cordyceps cicadae spore powder uniformly;
adding water into the uniformly mixed powder, controlling the ratio of feed to liquid to be 1:70, carrying out reflux extraction at the extraction temperature of 60 ℃ for 2 times, extracting for 3 hours each time, and centrifuging to obtain supernatant;
adding 6 times of ethanol into the supernatant, standing at 4deg.C for 24 hr, centrifuging, and collecting precipitate to obtain Cordyceps cicadae extractive powder;
(2) Uniformly mixing black beans, bighead atractylodes rhizome, chinese yam, medlar, rhizoma corydalis decumbentis and red dates, and grinding into 5mm powder for later use;
(3) Mixing the crushed powder in the step (2) with water according to a mass ratio of 1:8, soaking for 60min, decocting for 45min, and filtering to obtain first residues and first liquid medicine;
(4) Mixing the first medicine residues with water according to a mass ratio of 1:4, decocting for 60min, filtering to obtain second medicine residues and second medicine liquid, and mixing the first medicine liquid and the second medicine liquid to obtain a medicine liquid mixture;
(5) Stirring the cordyceps sobolifera extract powder obtained in the step (1) and the liquid medicine mixture obtained in the step (4) uniformly, adding citric acid, continuously stirring, concentrating (concentrating to a relative density of 1.25), drying, crushing and granulating in sequence, and obtaining the cordyceps sobolifera powder for enhancing immunity and improving renal function.
Comparative example 1
This comparative example differs from example 1 in that cordyceps sobolifera extract powder was not included, and the remaining steps were the same.
Comparative example 2
This comparative example differs from example 1 in that it does not include corydalis decumbens and Lycium barbarum, and the remaining steps are the same.
Comparative example 3
This comparative example differs from example 1 in that the bighead atractylodes rhizome and the yam are not included, and the remaining steps are the same.
Comparative example 4
The comparative example differs from example 1 in that the feed-to-liquid ratio in step (1) was 1:20, and the remaining steps were the same.
Comparative example 5
The comparative example differs from example 1 in that the feed-to-liquid ratio in step (1) is 1:100, and the rest steps are the same.
Comparative example 6
This comparative example differs from example 1 in that the extraction temperature in step (1) was 100℃and the remaining steps were the same.
Comparative example 7
This comparative example differs from example 1 in that the extraction temperature in step (1) was 45℃and the remaining steps were the same.
Test example 1
Enhancement immunity test:
(1) 320 rats were taken, weighing 30-50 g, and equally divided into 16 groups of 20, and the doses of the agents prepared in examples 1-9 and comparative examples 1-7 were administered once daily, each dose being 2g/kg, and the results of the rats were observed using the carbon clearance test and the serum hemolysin assay for seven consecutive days.
Carbon clearance experiment: indian ink diluted with 5-fold physiological saline was injected into the tail of the rat, the timing was started immediately after the injection of 0.1mL/10g of the ink, 20. Mu.L of blood was collected from the inner canthus venous plexus at 2 and 10min after the injection of the ink, and the obtained solution was added to 2mL of sodium carbonate solution, and the optical density value was measured at 600nm using a 723 spectrophotometer using the sodium carbonate solution as a blank. After blood collection, rats were sacrificed, livers and spleens were weighed, and phagocytosis index was calculated to express the ability of the mice to clear carbon.
Serum lysin assay: injecting 2% SRBC0.2ml of immunity into the abdominal cavity of each rat, continuing to irrigate the stomach for 7 days, removing eyeballs, taking blood in a centrifuge tube, standing for 1h, peeling, centrifuging at 2000rpm for 10min, collecting serum, diluting the serum by a multiple ratio with normal saline, diluting each part by 12 holes, placing the serum with different dilutions into a hemagglutination plate, adding 100 mu L of 0.5% SRBC suspension into each hole, uniformly mixing, placing the mixture into a wet box at 37 ℃ for 3h, observing the result, recording the agglutination degree of each hole, and calculating the number of antibody products.
The results of the immunity enhancing test are shown in table 1.
TABLE 1 serum hemolysin level and phagocytic Activity changes of macrophages
The method comprises the following steps: the serum hemolysin levels and phagocytic activity of macrophages in the experimental mice of examples 1-9 were both significantly improved over that before administration. The difference in the level of serum hemolysin and the phagocytic activity of macrophages in the experimental mice of comparative example 1 was smaller than the difference in the change before administration, the difference in the level of serum hemolysin and the phagocytic activity of macrophages in the experimental mice of comparative examples 2 to 3 was smaller than the difference in the change before administration, and the level of serum hemolysin and the phagocytic activity of macrophages in the experimental mice of comparative examples 4 to 7 were substantially unchanged or smaller than the difference before administration. The components in the application, especially the cordyceps sobolifera have great influence on enhancing the immunity of human bodies, and the extraction method of the cordyceps sobolifera active ingredients in the application comprises the steps of extracting the feed liquid ratio, extracting the temperature and the like, and has influence on the extraction rate of the cordyceps sobolifera active ingredients. Specifically, the application adopts the feed liquid ratio of 1:30-70, when the feed liquid ratio is lower than the ratio, the extraction rate of the cordyceps sobolifera polysaccharide and the amino acid is lower, and the extraction effect is not ideal; when the feed-liquid ratio is higher than the ratio, the extraction rate is not improved, but the efficiency is reduced due to the increased complexity of the extraction process, and the loss of active ingredients is caused, so that the feed-liquid ratio is selected to be 1:30-70. The extraction temperature adopted in the application is 50-90 ℃, and in the temperature range, the volatilization and loss of active ingredients caused by high temperature are avoided, and the effective extraction and separation cannot be realized due to too low temperature.
In conclusion, the compatibility of the components in the application is corresponding and is not necessary; the extraction parameters in the application are also the best results obtained after the effective test of the inventor, and the cordyceps cicadae powder with the best quality for enhancing immunity and improving kidney function can be obtained in the range provided by the application.
(2) The cordyceps cicadae powder particle preparation for enhancing immunity and improving kidney function prepared in the embodiment 1 of the application is taken as a test medicament by 200 groups of people of different ages, wherein 100 men and women respectively have the average number of people of ages of 30-50 years. Each person takes 10g of the Chinese medicinal composition in the morning, in the middle and in the evening each day, and takes the Chinese medicinal composition with boiled water.
After 30 days, more than 50% of people can feel that the physical state is obviously changed, the immunity is improved, the sleep quality is enhanced, the gas color is obviously improved, and the physique is obviously enhanced.
After 60 days, more than 90% of people can feel the improvement effect, and the lumbago disappears, and the sleeping quality is good.
After being continuously taken for 2 months, more than 99 percent of people can completely eliminate symptoms of insomnia, difficulty in falling asleep, easy awakening and daytime sleepiness, and the sleeping time is obviously prolonged.
Test example 2
Rat toxicity test:
200 rats are taken, the weight of the rats is 170-255 g, the cordyceps cicadae powder for enhancing immunity and improving kidney functions prepared by the method in examples 1-9 is used for lavage, the dosage is 60g/kg, and the continuous 24 hours are carried out, so that the blood of the animals is routine, the liver and kidney functions and the electrocardiogram are not abnormal, and the pathological examination of important organs such as heart, liver, spleen, lung and kidney is not obviously abnormal.
The foregoing is only a specific embodiment of the application to enable those skilled in the art to understand or practice the application. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the application. Thus, the present application is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. Cordyceps cicadae powder for enhancing immunity and improving kidney function is characterized by comprising the following raw materials in parts by weight: 15-40 parts of cordyceps cicadae extractive powder, 2-8 parts of black beans, 2-8 parts of bighead atractylodes rhizome, 1-5 parts of Chinese yam, 0.5-1.5 parts of medlar, 20-30 parts of rhizoma corydalis decumbentis, 5-10 parts of red dates and 1-3 parts of citric acid.
2. The cordyceps cicadae powder for enhancing immunity and improving kidney function according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 20-30 parts of cordyceps cicadae extractive powder, 3-6 parts of black beans, 3-6 parts of bighead atractylodes rhizome, 2-4 parts of Chinese yam, 0.8-1.2 parts of medlar, 20-25 parts of rhizoma corydalis decumbentis, 5-8 parts of red dates and 1.8-2 parts of citric acid.
3. The cordyceps cicadae powder for enhancing immunity and improving kidney function according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 25 parts of cordyceps cicadae extractive powder, 5 parts of black beans, 5 parts of bighead atractylodes rhizome, 3 parts of Chinese yam, 1 part of medlar, 20 parts of rhizoma corydalis decumbentis, 5 parts of red dates and 2 parts of citric acid.
4. The cordyceps sobolifera powder for enhancing immunity and improving kidney function according to any one of claims 1 to 3, wherein the cordyceps sobolifera extract powder comprises cordyceps sobolifera original powder and cordyceps sobolifera spore powder in a mass ratio of 80-95:5-20, and the cordyceps sobolifera original powder is prepared by pulverizing cordyceps sobolifera plants into fine powder which is sieved by a 20-50 mesh sieve.
5. A method for preparing cordyceps cicadae powder for enhancing immunity and improving renal function according to any one of claims 1 to 4, comprising the following steps:
extracting cordyceps cicadae powder by adopting an alcohol precipitation water extraction method to obtain cordyceps cicadae extract powder;
uniformly mixing the black beans, the bighead atractylodes rhizome, the Chinese yam, the medlar, the rhizoma corydalis decumbentis and the red dates, and grinding to obtain medicinal powder;
mixing the medicinal powder with water, soaking, decocting, and filtering to obtain first residue and first medicinal liquid;
mixing the first medicine residues with water, decocting, filtering to obtain second medicine residues and second medicine liquid, and mixing the first medicine liquid and the second medicine liquid to obtain a medicine liquid mixture;
and (3) uniformly stirring the cordyceps cicadae extract powder and the liquid medicine mixture, adding citric acid, continuously stirring, and sequentially concentrating, drying, crushing and granulating.
6. The method for preparing cordyceps cicadae powder for enhancing immunity and improving kidney function according to claim 5, wherein the alcohol precipitation and water extraction method specifically comprises the following steps:
weighing Cordyceps cicadae plant and Cordyceps cicadae spore powder according to a certain proportion, pulverizing Cordyceps cicadae plant into powder, and mixing with Cordyceps cicadae spore powder uniformly;
adding water into the uniformly mixed powder, carrying out reflux extraction at an extraction temperature of 50-90 ℃, and centrifuging to obtain a supernatant;
adding 2-10 times of ethanol into the supernatant, standing for 24-48 hours at the temperature of 4-5 ℃, centrifuging, and taking out the precipitate to obtain cordyceps cicadae extract powder.
7. The method for preparing cordyceps cicadae powder for enhancing immunity and improving kidney function according to claim 6, wherein the reflux extraction time is 2-4 h, the extraction times are 1-5 times, and the feed-liquid ratio is 1:30-70.
8. The method for preparing cordyceps cicadae powder for enhancing immunity and improving kidney function according to claim 5, wherein the particle size of the powder is 1-5 mm, the mass ratio of the powder to water is 1:5-10, the soaking time is 30-60 min, and the decocting time is 30-60 min.
9. The method for preparing cordyceps cicadae powder for enhancing immunity and improving kidney function according to claim 5, wherein the mixing mass ratio of the first medicine residues to water is 1:2-5, and the decoction time is 30-60 min.
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| CN107183679A (en) * | 2017-04-28 | 2017-09-22 | 浙江省亚热带作物研究所 | A kind of cordyceps sinensis instant, tablet and cordyceps militaris liquor for adjusting immunologic function |
| CN114698693A (en) * | 2022-04-12 | 2022-07-05 | 广州麦乐生物科技有限公司 | Formula and preparation method of cordyceps cicadae flower and cordyceps sinensis milk powder |
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| CN107183679A (en) * | 2017-04-28 | 2017-09-22 | 浙江省亚热带作物研究所 | A kind of cordyceps sinensis instant, tablet and cordyceps militaris liquor for adjusting immunologic function |
| CN114698693A (en) * | 2022-04-12 | 2022-07-05 | 广州麦乐生物科技有限公司 | Formula and preparation method of cordyceps cicadae flower and cordyceps sinensis milk powder |
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