CN109464509A - A kind of preparation method of Dan peach kernel granule - Google Patents

A kind of preparation method of Dan peach kernel granule Download PDF

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CN109464509A
CN109464509A CN201910012541.9A CN201910012541A CN109464509A CN 109464509 A CN109464509 A CN 109464509A CN 201910012541 A CN201910012541 A CN 201910012541A CN 109464509 A CN109464509 A CN 109464509A
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peach kernel
extraction
dan peach
dan
granule
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张慧
张克清
颜继忠
刘传鑫
陈燕
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Zhejiang University of Technology ZJUT
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The present invention provides a kind of preparation methods of Dan peach kernel granule, use the higher lactose of brittleness and mannitol for auxiliary material, it is the case where obtained medicinal extract powder heap density very little of raw material, the embryo piece that is pressed into be very soft, dry granulation difficult molding for Dan peach kernel medicine materical crude slice, its brittleness can be improved, solve pelletization in occur the problems such as being difficult to tabletting or soft embryo piece quality, the forming degree of granulation is improved, the present invention facilitates the application and popularization of Chinese medicinal granular formulation, has a vast market foreground.

Description

A kind of preparation method of Dan peach kernel granule
(1) technical field
The present invention relates to a kind of preparation methods of Dan peach kernel granule, specifically prepare using lactose, mannitol as auxiliary material Dan peach kernel Chinese medicinal granule, belongs to Chinese medicine preparation field.
(2) background technique
Chinese medicinal granule is a kind of unified specification for being processed into, unified agent by the extracted concentration of single medicinal material medicine materical crude slice The new formulation medication of amount, unified mass standard.It ensure that whole features of the former prepared slices of Chinese crude drugs, can satisfy doctor and distinguishes Card opinion is controlled, and is added and subtracted with card, pharmacological property is strong, drug effect is high, have again simultaneously do not need to decoct, directly take after mixing it with water, dose is few, effect is fast Speed, composition is complete, curative for effect, safety and sanitation, carry save it is convenient, be easy to modulate and suitable industrialized production etc. is many excellent Point.
Dan peach kernel is after peach kernel is cleaned, to set in boiling water, be heated to that kind of skin is micro- to be heaved, pull out, set in cold water and impregnate, and is taken out, Kind of skin and kernel is rubbed open, it is dry, medicine materical crude slice obtained from kind of skin is removed, there is promoting blood circulation, relax bowel and defecation, relieving cough and asthma function Effect.For amenorrhea and algomenorrhea, lump in the abdomen lump in the abdomen lump in the abdomen, pulmonary abscess acute appendicitis, injury from falling down, dry constipation of intestines, cough and asthma.Dan peach kernel Chinese medicine preparation Grain be using Dan peach kernel medicine materical crude slice as raw material, through modernize pharmaceutical technology be prepared, have it is identical with Dan peach kernel medicine materical crude slice effectively at Part, meridian distribution of property and flavor and attending effectiveness, conveniently take, carry, save, alternative traditional Chinese medicine standard decoction pushes away Chinese medicine Wide and development is of great significance.
The production technology of Chinese medicinal granule includes the production technologies such as extracting and developing, concentration, drying, granulation, packaging, but Using the medicinal extract powder heap density very little that Dan peach kernel medicine materical crude slice is obtained as raw material, the embryo piece being pressed into is very soft, and Dan peach is given in the molding of dry granulation difficulty The preparation process of benevolence Chinese medicinal granule causes certain difficulty.Lactose and mannitol are the higher auxiliary material of brittleness, Ke Yigai The brittleness of kind Dan peach kernel extract powder, solve to occur in pelletization the problems such as being difficult to tabletting or soft embryo piece quality, improve The forming degree of granulation facilitates the application and popularization of Chinese medicinal granular formulation, has a vast market foreground.
(3) summary of the invention
The purpose of the present invention is to provide a kind of preparation method of Dan peach kernel Chinese medicinal granule, feature is to overcome Dan peach The medicinal extract powder heap density very little that benevolence extract powder occurs in pelletization, the embryo piece being pressed into is very soft, dry granulation difficult forming Problem, and a kind of method for preparing Dan peach kernel Chinese medicinal granule as auxiliary material using lactose, mannitol is disclosed.
Technical scheme is as follows:
A kind of preparation method of Dan peach kernel granule, the preparation method include the following steps:
(1) raw material screening: it is raw material that screening, which meets Dan peach kernel medicine materical crude slice as defined in " Chinese Pharmacopoeia " (2015 editions), goes to clean Matter smashes it through 24 meshes；
The Dan peach kernel medicine materical crude slice is obtained by peach kernel medicinal material through processing, and the peach kernel medicinal material is " Chinese Pharmacopoeia " (2015 editions) rule Fixed rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana (Carr.) Franch. Dry mature seed；
(2) it decocts and extracts: using water as Extraction solvent, being mentioned decoct after the medicine materical crude slice immersion 30min of step (1) screening It takes, extracts twice, the solid-liquid ratio of medicine materical crude slice and water is 1:6~10 when extracting every time, and extraction time is 20~60min, crosses 200 while hot Filtrate is extracted in mesh, merging twice；
Preferably, the operating method of the extraction are as follows: the solid-liquid ratio of medicine materical crude slice and water is 1:10 when extracting for the first time, when extraction Between be 30min, cross 200 meshes while hot, take the dregs of a decoction to carry out second and extract, solid-liquid ratio 1:8, extraction time 30min, while hot 200 meshes are crossed, filtrate is extracted in merging twice；
(3) it is concentrated under reduced pressure: under 55~70 DEG C (preferably 60 DEG C), being concentrated into medicine for filtrate decompression is extracted obtained by step (2) Liquid density is 1.02~1.08g/mL (preferably 1.05g/mL), obtains and extracts concentrate；
(4) it is spray-dried: lactose is added in the extraction concentrate obtained by step (3), is spray-dried after mixing, Obtain extract powder；
The quality dosage of the lactose is extract solid quality contained by concentrate 10%~30%；
The inlet air temperature of the spray drying is 180~190 DEG C, leaving air temp is 80~90 DEG C；
(5) dry granulation: being added lactose or mannitol in the extract powder obtained by step (4), be uniformly mixed, obtain mixed powder End is pelletized, whole grain, and the Dan peach kernel granule is obtained；
Specifically, the method for the granulation, whole grain are as follows: use dry granulation, roll wheel speed 4r/min, pressure 12Mpa, water Flat feeding speed 50r/min, crush, sieving collect 10~40 mesh between (preferably 20 mesh) particle to get；
The quality dosage of the lactose or mannitol is the 10%~30% of extract powder quality.
The present invention has found that the medicinal extract powder heap density very little of Dan peach kernel, the embryo piece being pressed into is very soft in tabletting pelletization, does Legal system grain difficult forming.In this regard, the preferable auxiliary material of appropriate brittleness need to be added in extract powder before granulation, it is crisp to adjust extract powder Property, improve the forming degree of Chinese medicinal granule granulation.The present inventor uses the SMS of Britain Stable Micro System Texture Analyser property tester (Texture instrument) is measured the brittleness of several auxiliary materials, and as a result (being shown in Table 1) shows: cream The brittleness of sugar and mannitol is preferable.It above-mentioned auxiliary material is further respectively adopted is mixed with Dan peach kernel extract powder and pelletized, dry method system Grain molding yield such as table 2, as the result is shown: auxiliary material is not added, the embryo piece being pressed into is very soft, the molding of dry granulation difficulty.Add dextrin, crystallite fine Dimension element, maltodextrin fail to improve its embryo piece character, and only brittleness auxiliary material lactose and mannitol can improve embryo piece character, embryo It is higher that piece brittleness and hardness are obviously improved pelletizing forming degree.Added lactose and mannitol ratio are higher, and grain forming rate is higher, but Difference is little.It is worth noting that, excessive lactose, mannitol auxiliary material is added, will lead to sliver, it is same influence granulation as a result, Therefore, added auxiliary material amount need to be controlled in the reasonable scope.
1 auxiliary material brittleness measurement result of table
2 Dan peach kernel of table granulation result
Note: grain forming rate %=(embryo sheet weight used in particle weight/granulation is made) × 100%
Compared with the existing technology, the invention has the benefit that having invented a kind of preparation method of Dan peach kernel granule, Use the higher lactose of brittleness and mannitol for auxiliary material, for Dan peach kernel medicine materical crude slice be raw material obtain medicinal extract powder heap density very little, The case where embryo piece being pressed into is very soft, dry granulation difficult molding can improve its brittleness, and solve to occur in pelletization is difficult to press The problems such as piece or soft embryo piece quality, improve the forming degree of granulation.The application and popularization for facilitating Chinese medicinal granular formulation, have Vast market prospect.
(4) specific embodiment
The present invention is described in further details below by specific embodiment, but protection scope of the present invention and is not only limited In this.
Dan peach kernel medicine materical crude slice used in embodiment is obtained by peach kernel medicinal material through processing, and the peach kernel medicinal material is " Chinese Pharmacopoeia " Rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana as defined in (2015 editions) (Carr.) dry mature seed of Franch., the concocting method of Dan peach kernel medicine materical crude slice: taking net peach kernel, set in boiling water, is heated to planting Pi Wei heaves, and pulls out, sets in cold water and impregnates, and takes out, kind of skin and kernel is rubbed open, dry, removes kind of a skin.Used time smashs to pieces.
Embodiment one
(1) raw material screening: being detected Dan peach kernel medicine materical crude slice by " Chinese Pharmacopoeia " (2015 editions) regulations, and screening meets regulation Medicine materical crude slice be raw material, remove impurity, smash it through 24 meshes；
Medicine materical crude slice character as defined in meeting: it is smaller and plump to be about 1cm, wide about 0.7cm, thickness about 0.5cm in class oval, Off-white color, it is High oleic.Gas is micro-, mildly bitter flavor.Identify: using thin-layered chromatography, in sample chromatogram, with amarogentin reference substance On the corresponding position of chromatography, the spot of same color is shown.Check: acid value must not cross 10.0；Carbonyl value must not cross 11.0；This product is every 1000g contains aflatoxin B15 μ g must not be crossed, aflatoxin G is contained2, aflatoxin G1, aflatoxin B2And aspergillus flavus Toxin B1Total amount must not cross 10 μ g.The assay: (C containing amarogentin20H27NO11) 1.50% must not be less than.
(2) it decocts and extracts: using water as Extraction solvent, decoction extraction will be carried out after the raw material soaking 30min of screening, extracts two It is secondary, wherein the mixing ratio of spice and water be it is primary extract 1:10, second extraction 1:8, extraction time be it is primary extract 60min, Second extraction 30min, is filtered while hot, is merged and is decocted filtrate；
(3) be concentrated under reduced pressure: thickening temperature is 55 DEG C, and being concentrated under reduced pressure into medical fluid density is 1.03g/mL, obtains and extracts concentration Liquid；
(4) it is spray-dried: the lactose that concentrate solid content ratio is 30% will be accounted for and be added to extracting in concentrate, mixed It closes uniformly, to mixed solution using being spray-dried, spray drying EAT is 180~185 DEG C, leaving air temp is 85 DEG C；
(5) dry granulation:
Method 1: will be added 10% lactose and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 20 mesh.
Method 2: will be added 10% mannitol and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 20 mesh.
Embodiment two
(1) raw material screening: being detected Dan peach kernel medicine materical crude slice by " Chinese Pharmacopoeia " (2015 editions) regulations, and screening meets regulation Medicine materical crude slice be raw material, remove impurity, smash it through 24 meshes；
(2) it decocts and extracts: using water as Extraction solvent, decoction extraction will be carried out after the raw material soaking 30min of screening, extracts two Secondary, wherein the mixing ratio of spice and water is primary extraction 1:8, second extraction 1:6, and extraction time is once to extract 30min, two Secondary extraction 30min, is filtered while hot, is merged and is decocted filtrate；
(3) be concentrated under reduced pressure: thickening temperature is 65 DEG C, and being concentrated under reduced pressure into medical fluid density is 1.02g/mL, obtains and extracts concentration Liquid；
(4) it is spray-dried: the lactose that concentrate solid content ratio is 15% will be accounted for and be added to extracting in concentrate, mixed It closes uniformly, to mixed solution using being spray-dried, spray drying EAT is 180~185 DEG C, leaving air temp is 90 DEG C；
(5) dry granulation:
Method 1: will be added 20% lactose and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 10 mesh.
Method 2: will be added 20% mannitol and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 10 mesh.
Embodiment three
(1) raw material screening: being detected Dan peach kernel medicine materical crude slice by " Chinese Pharmacopoeia " (2015 editions) regulations, and screening meets regulation Medicine materical crude slice be raw material, remove impurity, smash it through 24 meshes；
(2) it decocts and extracts: using water as Extraction solvent, decoction extraction will be carried out after the raw material soaking 30min of screening, extracts two Secondary, wherein the mixing ratio of spice and water is primary extraction 1:8, second extraction 1:6, and extraction time is once to extract 40min, two Secondary extraction 20min, is filtered while hot, is merged and is decocted filtrate；
(3) be concentrated under reduced pressure: thickening temperature is 70 DEG C, and being concentrated under reduced pressure into medical fluid density is 1.08g/mL, obtains and extracts concentration Liquid；
(4) it is spray-dried: the lactose that concentrate solid content ratio is 20% will be accounted for and be added to extracting in concentrate, mixed It closes uniformly, to mixed solution using being spray-dried, spray drying EAT is 185~190 DEG C, leaving air temp is 85 DEG C；
(5) dry granulation:
Method 1: will be added 20% lactose and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 30 mesh.
Method 2: will be added 20% mannitol and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 30 mesh.
Example IV
(1) raw material screening: being detected Dan peach kernel medicine materical crude slice by " Chinese Pharmacopoeia " (2015 editions) regulations, and screening meets regulation Medicine materical crude slice be raw material, remove impurity, smash it through 24 meshes；
(2) it decocts and extracts: using water as Extraction solvent, decoction extraction will be carried out after the raw material soaking 30min of screening, extracts two It is secondary, wherein the mixing ratio of spice and water be it is primary extract 1:10, second extraction 1:8, extraction time be it is primary extract 40min, Second extraction 30min, is filtered while hot, is merged and is decocted filtrate；
(3) be concentrated under reduced pressure: thickening temperature is 60 DEG C, and being concentrated under reduced pressure into medical fluid density is 1.03g/mL, obtains and extracts concentration Liquid；
(4) it is spray-dried: the lactose that concentrate solid content ratio is 10% will be accounted for and be added to extracting in concentrate, mixed It closes uniformly, to mixed solution using being spray-dried, spray drying EAT is 185~190 DEG C, leaving air temp is 85 DEG C；
(5) dry granulation:
Method 1: will be added 30% lactose and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 20 mesh.
Method 2: will be added 30% mannitol and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 20 mesh.
Embodiment five
(1) raw material screening: being detected Dan peach kernel medicine materical crude slice by " Chinese Pharmacopoeia " (2015 editions) regulations, and screening meets regulation Medicine materical crude slice be raw material, remove impurity, smash it through 24 meshes；
(2) it decocts and extracts: using water as Extraction solvent, decoction extraction will be carried out after the raw material soaking 30min of screening, extracts two It is secondary, wherein the mixing ratio of spice and water be it is primary extract 1:10, second extraction 1:8, extraction time be it is primary extract 60min, Second extraction 60min, is filtered while hot, is merged and is decocted filtrate；
(3) be concentrated under reduced pressure: thickening temperature is 65 DEG C, and being concentrated under reduced pressure into medical fluid density is 1.06g/mL, obtains and extracts concentration Liquid；
(4) it is spray-dried: the lactose that concentrate solid content ratio is 25% will be accounted for and be added to extracting in concentrate, mixed It closes uniformly, to mixed solution using being spray-dried, spray drying EAT is 185~190 DEG C, leaving air temp is 90 DEG C；
(5) dry granulation:
Method 1: will be added 15% lactose and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 40 mesh.
Method 2: will be added 15% mannitol and be uniformly mixed, obtain mixed-powder, mixed-powder is pelletized in extract powder, whole Grain, is made the Chinese medicinal granule of 40 mesh.
Embodiment six
Dan peach kernel granule prepared by the present invention and commercially available Dan peach kernel granule granularity, moisture, molten has been subjected to The comparison (being shown in Table 3) of the property changed and index components content, evaluates preparation process of the present invention.
Table 3
The results show that Dan peach kernel granule prepared by the present invention (cannot lead to commercially available Dan peach kernel granule granularity The summations crossing No.1 sieve and capable of being sieved by No. five), moisture, melting meet regulation.But Dan peach kernel prepared by the present invention is matched The granularity of square particle is better than commercially available Dan peach kernel granule；Dan peach kernel granule moisture prepared by the present invention is lower than commercially available Dan Peach kernel granule；Dan peach kernel granule index components content prepared by the present invention is higher than commercially available Dan peach kernel granule.

Claims (4)

1. a kind of preparation method of Dan peach kernel granule, which is characterized in that the preparation method includes the following steps:
(1) raw material screening: it is raw material that screening, which meets Dan peach kernel medicine materical crude slice as defined in " Chinese Pharmacopoeia ", removes impurity, smashes it through 24 Mesh；
(2) it decocts and extracts: using water as Extraction solvent, carrying out decoction extraction after the medicine materical crude slice of step (1) screening is impregnated 30min, mention It taking twice, the solid-liquid ratio of medicine materical crude slice and water is 1:6~10 when extracting every time, and extraction time is 20~60min, 200 meshes are crossed while hot, Filtrate is extracted in merging twice；
(3) be concentrated under reduced pressure: at 55~70 DEG C, will extract obtained by step (2) filtrate decompression be concentrated into medical fluid density be 1.02~ 1.08g/mL is obtained and is extracted concentrate；
(4) it is spray-dried: lactose is added in the extraction concentrate obtained by step (3), is spray-dried, is obtained after mixing Extract powder；
The quality dosage of the lactose is extract solid quality contained by concentrate 10%~30%；
(5) dry granulation: being added lactose or mannitol in the extract powder obtained by step (4), be uniformly mixed, obtain mixed-powder, It is pelletized, whole grain, obtains the Dan peach kernel granule；
The quality dosage of the lactose or mannitol is the 10%~30% of extract powder quality.
2. the preparation method of Dan peach kernel granule as described in claim 1, which is characterized in that in step (2), the extraction Operating method are as follows: for the first time extract when medicine materical crude slice and water solid-liquid ratio be 1:10, extraction time 30min, while hot cross 200 mesh Sieve, takes the dregs of a decoction to carry out second and extracts, and solid-liquid ratio 1:8, extraction time 30min cross 200 meshes while hot, and merging mentions twice Take filtrate.
3. the preparation method of Dan peach kernel granule as described in claim 1, which is characterized in that described spraying in step (4) Dry inlet air temperature is 180~190 DEG C, leaving air temp is 80~90 DEG C.
4. the preparation method of Dan peach kernel granule as described in claim 1, which is characterized in that in step (5), the system The method of grain, whole grain are as follows: use dry granulation, roll wheel speed 4r/min, pressure 12Mpa, straight feeding speed 50r/min, powder It is broken, sieving collect 10~40 mesh between particle to get.
CN201910012541.9A 2019-01-07 2019-01-07 A kind of preparation method of Dan peach kernel granule Pending CN109464509A (en)

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CN111358824A (en) * 2020-04-08 2020-07-03 亳州益智健康产业有限公司 Preparation method of honeysuckle flower formula granules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105497393A (en) * 2014-10-11 2016-04-20 复旦大学附属妇产科医院 Traditional Chinese medicine compound preparation for treating endometriosis and preparation method thereof
CN107115378A (en) * 2017-06-20 2017-09-01 周光姣 One kind is relieved the effect of alcohol the flower granule and preparation method thereof of lipid-loweringing five

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105497393A (en) * 2014-10-11 2016-04-20 复旦大学附属妇产科医院 Traditional Chinese medicine compound preparation for treating endometriosis and preparation method thereof
CN107115378A (en) * 2017-06-20 2017-09-01 周光姣 One kind is relieved the effect of alcohol the flower granule and preparation method thereof of lipid-loweringing five

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111358824A (en) * 2020-04-08 2020-07-03 亳州益智健康产业有限公司 Preparation method of honeysuckle flower formula granules

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Inventor after: Zhang Keqing

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Inventor after: Yan Jizhong

Inventor after: Liu Chuanxin

Inventor after: Chen Yan

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Application publication date: 20190315