CN106880759A - The preparation method of granular pattern ginseng jujube kernel health preserving tea and its health preserving tea of preparation - Google Patents
The preparation method of granular pattern ginseng jujube kernel health preserving tea and its health preserving tea of preparation Download PDFInfo
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- CN106880759A CN106880759A CN201710198099.4A CN201710198099A CN106880759A CN 106880759 A CN106880759 A CN 106880759A CN 201710198099 A CN201710198099 A CN 201710198099A CN 106880759 A CN106880759 A CN 106880759A
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- health preserving
- jujube kernel
- preserving tea
- preparation
- ginseng
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Classifications
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Abstract
The invention discloses the preparation method and its health preserving tea of preparation of granular pattern ginseng jujube kernel health preserving tea, specific preparation method comprises the following steps：(1) the raw material Chinese herbal medicine of ginseng jujube kernel health preserving tea is prepared according to formula ratio；(2) half of each raw material Chinese herbal medicine is ground into meal, and second half is by being extracted into thick paste；Then meal and thick paste mix again；(3) to adding pharmaceutically acceptable auxiliary material, softwood processed in the mixture of meal and thick paste；Then circular or bar shaped or special-shaped bulky grain are made, through drying, particle surface of polishing obtains final product granular pattern ginseng jujube kernel health preserving tea.This product can allow people cosily to sample tea while convenient and more preferable consumption experience is met, do not allow sample tea people feel granule contacted with medicine phases, can reach the effect of medicine-food two-purpose, have functions that to take care of health and be healthy and strong.
Description
Technical field
The present invention relates to traditional Chinese medicine health field, more specifically to a kind of system of granular pattern ginseng jujube kernel health preserving tea
Preparation Method and its health preserving tea of preparation.
Background technology
Tea bag be it is a kind of using long fibre filter paper special, special, with netted eyelet different tealeaves and other
Inclusion is wrapped in paper bag, and what is had wraps outer paper bag outside filter paper again, and the tea products for being formed.The bubble drink of tea bag compares
It is convenient and swift, need to be particular about the time of tea set, skill of making tea, tea ceremony tea ceremony like that without loose tea bubble drink, therefore it is deep by people's
Pursue.Meanwhile, with the enhancing that people's health is realized, after tea-drinking market expands rapidly, Chinese traditional herbs are main component
Health protection tea, such as benefit mother eight delicacies tea bag, four things drink tea bag, three plain soup tea bags have turned into the new highlight in major markets.
However, this tea bag with healthcare function typically carries out simply decoction, concentration to formula enters bag, do not consider how
The active ingredient in medicine is fully extracted, other has the Chinese herbal medicine of niff or taste, it is difficult to make tea bag,
And, tea bag is typically all to brew 1 time afterwards just to discard tea grounds.Because this tealeaves passes through to cut to rub in processing and manufacturing,
Be sufficiently destroyed leaf cell, formed graininess or the tiny sheet of shape, the effective content in tealeaves be easy to when brewing by
Leach and.Therefore, tea bag cannot also meet and can comfortably be sampled tea when convenient, while have functions that to take care of health being healthy and strong.
The content of the invention
The technical problem to be solved in the present invention is, for the drawbacks described above of prior art, there is provided a kind of granular pattern ginseng
The preparation method of jujube kernel health preserving tea and its health preserving tea of preparation.Ginseng jujube kernel health preserving tea of the invention is made one kind as coffee bean is big
Small circle or bar shaped or special-shaped bulky grain, can be taken after being infused in hot water or decoction and drink, and also can directly swallow, and it is very convenient to drink.The granular pattern ginseng
The speed ratio of jujube kernel health preserving tea insoluble drug release within four hours relatively relaxes, because the half raw material of ginseng jujube kernel health preserving tea is made
Meal, second half effective component extracting, the meal immersion when active ingredient be not easy to discharge, and it is extracted after thick paste
Its active ingredient is high, easily discharges, therefore in immersion early stage, comes from the thick of extraction the dark brown of millet paste, fragrance, flavour more
Cream, and come from the slow release of meal the dark brown of later stage millet paste, fragrance, flavour, the health preserving tea can allow people's cosily product more
Tea, and coffee bean size bulky grain, it is different from conventional medicinal grain shape, do not allow sample tea people feel granule and
Medicine phases are contacted, and can reach the effect of medicine-food two-purpose.Therefore, this product is while convenient and more preferable consumption experience is met, energy
People is enough allowed cosily to sample tea, while also having functions that to take care of health to be healthy and strong.
The technical solution adopted for the present invention to solve the technical problems is：
First purpose of the invention is to provide a kind of preparation method of granular pattern ginseng jujube kernel health preserving tea, specific to prepare
Method comprises the following steps：
(1) the raw material Chinese herbal medicine of ginseng jujube kernel health preserving tea is prepared according to formula ratio；
(2) half of each raw material Chinese herbal medicine is ground into meal, and second half is by being extracted into thick paste；Then meal and thick paste
Mix again；
(3) to adding pharmaceutically acceptable auxiliary material, softwood processed in the mixture of meal and thick paste；Then it is made circle
Or bar shaped or special-shaped bulky grain, through drying, particle surface of polishing obtains final product granular pattern ginseng jujube kernel health preserving tea.
Further, the ginseng jujube kernel health preserving tea is made up of the component of following parts by weight：Ginseng 20-30 parts, jujube kernel
10-15 parts, sealwort 10-15 parts, Poria cocos 10-15 parts, radix polygonati officinalis 10-15 parts, balsam pear 5-10 parts, balloonflower root 5-10 parts；
The extraction process of the step (2) is as follows：
(2.1) ginseng, jujube kernel, balloonflower root extract total saposins using the method for refluxing extraction；
(2.2) sealwort, Poria cocos, radix polygonati officinalis extract plant polyose using water extraction and alcohol precipitation method；
(2.3) balsam pear extracts Bitter Melon P.E using ultrasonic extraction.
Further, the reflux extraction method of total saposins is as follows in the step (2.1)：Ginseng, jujube kernel, balloonflower root is taken to crush
Into meal, petroleum ether degreasing 3 times, each 600ml, after with 70% ethanol 500mL refluxing extractions 3 times, Extracting temperature is 70 DEG C, often
Secondary one hour；Merge extract solution, reclaim ethanol, must dry to the medicinal extract of constant weight；Medicinal extract uses the total soap of purification with macroreticular resin
Glycosides, takes wet resin, and blade diameter length ratio is 1:20, use 70% ethanol elution, flow velocity to be 2BV/h, eluent is collected, after reclaiming ethanol,
Concentrate drying, obtains final product the total saposins of ginseng, jujube kernel and balloonflower root.
Further, the macroporous absorbent resin is in AB-8, NKA-9, HPD-100, D-101, D-301, X-5
Kind.
Further, defoamer is added during the eluent concentrate drying, wherein thickening temperature is 65 DEG C, defoamer
Concentration be 0.05-0.08g/ml, the amount ratio of eluent and defoamer is (8-10)：1；The defoamer disappears for silicone emulsion
One kind in infusion, 95% industrial alcohol, CL-259 medicine fermentation defoaming agents.
Further, the extracting method of plant polyose is as follows in the step (2.2)：Sealwort, Poria cocos, radix polygonati officinalis are added 8 times
The water of amount, 2-4h, filtering are extracted at 98-100 DEG C, and the dregs of a decoction add 8 times of water of amount to extract 2-4h at 98-100 DEG C, squeeze dregs of a decoction water to the greatest extent again
Point, filtering, merging filtrate is concentrated into equivalent to crude drug 0.5g/mL, plus ethanol stirring makes alcohol content up to 80%, and slow quickening is stirred,
Alcohol precipitation 24h, suction filtration washs precipitation with 95% ethanol of 4 times of medicinal material volume weights, waves to without alcohol taste, being dissolved in water to medicinal material body
2 times of product weight, adjust pH to 8-9, add anhydrous calcium chloride, make W/V up to 7%, dissolve, and place room temperature, and centrifugation takes supernatant dense
Thick paste is reduced to, 95 DEG C of drying under reduced pressure are obtained final product.
Further, the ultrasonic extraction of balsam pear is as follows in the step (2.3)：Balsam pear is ground into meal, in ultrasonic work(
Rate is 350w, and Extracting temperature is 60 DEG C, and the ultrasonic extraction time is 1h, and extract solution concentrate drying obtains final product Bitter Melon P.E.
Further, step (3) comprise the following steps that：
(3.1) meal and the total saposins of step (2.1)-(2.3) extraction, plant polyose, Bitter Melon P.E are mixed
Total thick paste；
(3.2) auxiliary material hydroxypropyl methyl cellulose, PVP k, microcrystalline cellulose, magnesium stearate are taken, 100 mesh is crossed respectively
Sieve；
(3.3) total thick paste obtained in step (3.1)-(3.2) is taken, adds hydroxypropyl methyl cellulose tentatively to be mixed,
Disintegrant PVP k, microcrystalline cellulose are added, appropriate 95% ethanol is added with softwood processed, the granulation of 4 mesh sieves, 45 DEG C of dryings is crossed
1-3 hours, then it is made circular or bar shaped or special-shaped bulky grain；Dried bulky grain mixes with magnesium stearate lubricant again
It is even, large particle surface of polishing, you can slow-releasing granules type ginseng jujube kernel health preserving tea is obtained.
Further, total thick paste described in the step (3.3)：Hydroxypropyl methyl cellulose：Disintegrant：The use of lubricant
Amount ratio is 1：(0.2-0.6):0.06:0.03；The disintegrant PVP k, the usage ratio of microcrystalline cellulose are (0.2-
1):1。
Second object of the present invention is also to provide a kind of granular pattern ginseng jujube kernel health preserving tea, by particle as described above
The preparation method of type ginseng jujube kernel health preserving tea is prepared.
Implement the preparation method of granular pattern ginseng jujube kernel health preserving tea of the invention and its health preserving tea of preparation, have with following
Beneficial effect：
(1) ginseng jujube kernel health preserving tea of the invention is made the circle or bar shaped or big of abnormity of a kind of picture coffee bean size
Grain, can be taken after being infused in hot water or decoction and drink, and also can directly swallow, and it is very convenient to drink.Granular pattern ginseng jujube kernel health preserving tea medicine within four hours
The speed ratio of thing release relatively relaxes, because the half raw material of ginseng jujube kernel health preserving tea is made meal, second half effective component extracting,
Meal active ingredient in immersion is not easy to discharge, and it is extracted after thick paste its active ingredient it is high, easily discharge
Come, therefore in immersion early stage, come from the thick paste of extraction more the dark brown of millet paste, fragrance, flavour, and dark brown, the perfume (or spice) of later stage millet paste
Coming from the slow release of meal gas, flavour, the health preserving tea can allow people cosily to sample tea more, and big of coffee bean size
Grain, it is different from conventional medicinal grain shape, do not allow people's sensation granule of sampling tea to be contacted with medicine phases, therefore, this product exists
While meeting convenient and more preferable consumption experience, people can be allowed cosily to sample tea, have functions that to take care of health and be healthy and strong.
(2) present invention takes into full account difference of the active component of each taste Chinese herbal medicine in tea side in species, structure, physicochemical property
On the basis of different, said extracted technique is optimized, significantly improve drug effect；Additionally, also by selecting appropriate sustained-release matrix
Material, control auxiliary material appropriate consumption, be made slow-releasing granules, be user during health preserving tea of taking after mixing it with water, having in tea side
Effect composition slowly discharges, and to reach tea perfume more fresh natural, mouthfeel is full abundant, the yellowish green bright effect of color.
(3) in addition, the granular pattern ginseng jujube kernel health preserving tea of present invention preparation, drinks by long-time, with tonifying Qi and blood,
Effect of relieving mental strain and helping sleep.It is main to take into full account the active component of each taste Chinese herbal medicine in tea side in species, structure, reason by the present invention
Change on the basis of qualitative difference, Different Extraction Method and different solvents are respectively adopted carries out classification extraction to bulk drug, with
Phase while consumption is reduced, significantly improves drug effect, the formula is had excellent tonifying Qi and blood, relieving mental strain and helping sleep effect.
(4) speed ratio of granular pattern ginseng jujube kernel health preserving tea insoluble drug release within four hours relatively relaxes, and makes tea perfume more
Fresh natural, mouthfeel is full abundant, and color is yellowish green bright, and four hours do not change, and comes accordingly, with respect to existing tea bag
Say, overcome after tea bag only soaks once, the defect that tea flavour is had a greatly reduced quality.In addition, inventor has found, hydroxypropyl methyl fiber
Release yet its important effect of the consumption of element to whole tea side, is not that arbitrarily addition can play releasing for fine control tea flavour
The function of putting, can only be in preferable amount (0.2-0.6), and its effect is only relatively good.The selection of disintegrant of the invention
And the key for looking good, smell good and taste good of health preserving tea of the present invention is also achieved in the distribution of consumption, make the formula that there is excellent sustained release to imitate
Really.
Specific embodiment
Below, with reference to specific embodiment, the present invention is described further：
In the present invention, if not refering in particular to, all of part, percentage are unit of weight, equipment and raw material for being used etc.
It is commercially available or commonly used in the art.Method in following embodiments, unless otherwise instructed, is the normal of this area
Rule method.
A kind of granular pattern ginseng jujube kernel health preserving tea of the invention is by the component of following parts by weight through granulating process preparation
Into：25 parts of ginseng, 12 parts of jujube kernel, 12 parts of sealwort, 13 parts of Poria cocos, 13 parts of radix polygonati officinalis, 8 parts of balsam pear, 8 parts of balloonflower root；
The pharmacological action of each Chinese herbal medicine is as follows：
Ginseng：It is the root of Araliaceae ginseng Panax ginseng C.A.Mey.Sweet, slight bitter, it is warm in nature, flat.Return
Spleen, lung channel, the heart channel of Hang-Shaoyin.Tonifying Qi, Gu it is de-, promote the production of body fluid, calm the nerves, intelligence development.For dyspnea with shortness of breath, palpitation and amnesia, thirsty hidrosis, deficiency of food without
Power, all acute and chronic diseases and the shock caused after losing blood, collapse.Reinforce vital energy, Gu de- promote the production of body fluid, calm the nerves.
Jujube kernel：It is the dry seed of Rhamnaceae arbor wild jujube Ziziphus jujuba Mill.var.spinosa.Sweet,
Acid, it is mild-natured.Conscience can be nourished, is calmed the nerves, arrest sweating.Have to illnesss such as restlessness of asrhenia type and insomnia, palpitation with fear palpitation, physically weak spontaneous perspirations and preferably control curative effect
Really.
Sealwort：It is the dry rhizome of liliaceous plant sealwort Polygonatum sibiricum.Nature and flavor are sweet, flat.Return through
Spleen, lung, kidney channel.With boosting qi and nourishing yin, invigorating the spleen, moistening lung, kidney-nourishing effect.With resisting pathogenic microbes, it is anti-oxidant, antifatigue, prolong
The effect of slow aging.
Poria cocos：It is the dry sclerotia of On Polyporaceae Poria cocos Poria cocos (Schw.) Wolf.It is sweet, light, put down.Return through
The thoughts of returning home, lung, spleen, kidney channel.Indication clearing damp and promoting diuresis, invigorating the spleen calming heart.For oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool
Diarrhea, confused and worried, insomnia of palpitating with fear.
Radix polygonati officinalis：It is the dry rhizome of liliaceous plant radix polygonati officinalis Polygonatum odoratum (Mill.) Druce.Nature and flavor：
It is sweet；It is flat.Return through：Lung channel；Stomach.Tool yin-nourishing, moisturize, heat-clearing, promote the production of body fluid, cough-relieving the effects such as.As tonic, pyreticosis wound is cured mainly
The disease such as the moon, abnormal heat cough caused by dryness, heart disease, diabetes, tuberculosis.
Balsam pear：The dry fruit of Curcurbitaceae balsam pear platymiscium balsam pear Momordica charantia L..Hardship, trembles with fear.Heat-clearing
Removing toxic substances, improving eyesight.For heatstroke heating, toothache, diarrhea, dysentery is had blood in stool.
Balloonflower root：It is the dry root of Campanulaceae balloonflower root Platycodon grandiflorus.Taste is pungent, it is cold in nature.Return lung,
Stomach two is passed through.Facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia, sound is mute, lung carbuncle pyemesis, sore purulence into
Do not burst.
In specific embodiment of the invention, the preparation method of each embodiment granular pattern ginseng jujube kernel health preserving tea is including as follows
Step：
(1) the raw material Chinese herbal medicine of ginseng jujube kernel health preserving tea is prepared according to formula ratio；
(2) half of each raw material Chinese herbal medicine is ground into meal, and second half is by being extracted into thick paste；Then meal and thick paste
Mix again；
Wherein, the extraction process of step (2) is as follows：
(2.1) ginseng, jujube kernel, balloonflower root extract total saposins using the method for refluxing extraction：Take ginseng, jujube kernel, balloonflower root
Be ground into meal, petroleum ether degreasing 3 times, each 600ml, after with 70% ethanol 500mL refluxing extractions 3 times, Extracting temperature is 70
DEG C, one hour every time；Merge extract solution, reclaim ethanol, must dry to the medicinal extract of constant weight；Medicinal extract uses purification with macroreticular resin
Total saposins, take wet resin, and blade diameter length ratio is 1:20, use 70% ethanol elution, flow velocity to be 2BV/h, eluent is collected, reclaim ethanol
Afterwards, concentrate drying, adds defoamer during concentrate drying, wherein thickening temperature is 65 DEG C, and the concentration of defoamer is 0.05-
0.08g/ml, eluent is (8-10) with the amount ratio of defoamer：1, obtain final product the total saposins of ginseng, jujube kernel and balloonflower root.
Preferably, macroporous absorbent resin is the one kind in AB-8, NKA-9, HPD-100, D-101, D-301, X-5.As
Optimal case of the present invention, i.e. D-101 types macroporous absorbent resin, with good macroreticular structure, regeneration is simple, and effect can
Lean on, its larger specific surface area can selectively adsorb organic matter by physical absorption, especially to ginseng, jujube kernel and balloonflower root
Total saposins have isolated and purified better effects, and because of its reasonable price, easy to use, the separation being suitable in laboratory and pharmaceutical factory is pure
Chemical industry is applied in making.
Preferably, defoamer is silicone emulsion defoamer (purchased from Chongqing ten thousand and Food Co., Ltd), 95% industrial wine
Essence (being purchased from Changsha Hui Hong chemical reagent Co., Ltd), CL-259 medicine fermentation defoaming agents are (prosperous purchased from Shandong Yantai
Chemical Co., Ltd.) in one kind.As optimal case of the present invention, i.e., using silicone emulsion defoamer, through lot of experiments
Prove, compared with other two kinds of defoamers, the concentration of the total saposins using silicone emulsion defoamer for ginseng, jujube kernel and balloonflower root
During, bubble liquid surface tension reduction degree maximum can be made, defoamed ratio highest is 48.78%, and concentration time can subtract
Be less original 50%, at the same through total saponin content determination experiment show to add defoamer to the content of index components total saposins without
Influence, therefore be the optimal defoamer of ginseng jujube kernel health preserving tea.
(2.2) sealwort, Poria cocos, radix polygonati officinalis extract plant polyose using water extraction and alcohol precipitation method：Sealwort, Poria cocos, radix polygonati officinalis are added 8
The water of amount, 2-4h, filtering are extracted at 98-100 DEG C again, and the dregs of a decoction add 8 times of water of amount in 98-100 DEG C of extraction 2-4h, squeeze the dregs of a decoction to the greatest extent again
Moisture, filtering, merging filtrate is concentrated into equivalent to crude drug 0.5g/mL, plus ethanol stirring makes alcohol content up to 80%, delays and accelerates
Stir, alcohol precipitation 24h, suction filtration, precipitation is washed with 95% ethanol of 4 times of medicinal material volume weights, wave to without alcohol taste, being dissolved in water to medicinal material
2 times of volume weight, adjust pH to 8-9, add anhydrous calcium chloride, make W/V up to 7%, dissolve, and place room temperature, and centrifugation takes supernatant
Thick paste is concentrated into, 95 DEG C of drying under reduced pressure are obtained final product.
(2.3) balsam pear extracts Bitter Melon P.E using ultrasonic extraction：Balsam pear is ground into meal, is in ultrasonic power
350w, Extracting temperature is 60 DEG C, and the ultrasonic extraction time is 1h, and extract solution concentrate drying obtains final product Bitter Melon P.E.
(3) it is made comprising the following steps that for granule：
(3.1) meal and the total saposins of step (2.1)-(2.3) extraction, plant polyose, Bitter Melon P.E are mixed
Total thick paste；
(3.2) auxiliary material hydroxypropyl methyl cellulose, PVP k, microcrystalline cellulose, magnesium stearate are taken, 100 mesh sieves is crossed respectively；
(3.3) total thick paste obtained in step (3.1)-(3.2) is taken, adds hydroxypropyl methyl cellulose tentatively to be mixed,
Disintegrant PVP k, microcrystalline cellulose are added, appropriate 95% ethanol is added with softwood processed, the granulation of 4 mesh sieves, 45 DEG C of dryings is crossed
1-3 hours, then it is made circular or bar shaped or special-shaped bulky grain；Dried bulky grain mixes with magnesium stearate lubricant again
It is even, large particle surface of polishing, you can slow-releasing granules type ginseng jujube kernel health preserving tea is obtained.Wherein, total thick paste：Hydroxypropyl methyl
Cellulose：Disintegrant：The usage ratio of lubricant is 1：(0.2-0.6):0.06:0.03；The disintegrant PVP k, crystallite
The usage ratio of cellulose is (0.2-1):1.
Embodiment 1-3, comparative example 1-3
Table 1：Embodiment 1-3, comparative example 1-3 ratio of adjuvant tables
Confirmatory experiment example
1st, the sense organ evaluation and test of health preserving tea：
Sense organ evaluation and test is carried out to granular pattern ginseng jujube kernel health preserving tea prepared by embodiment 1-3, respectively the institute of Example 1,2,3
20 grams of granular pattern ginseng jujube kernel health preserving tea is obtained, successively labeled as B, C, D；160 grams of normal-temperature waters are separately added into, are stirred, be obtained
Health preserving tea；Conventional ginseng jujube kernel life-nourishing tea bag is taken simultaneously, numbering is A, takes the blind mode commented, with reference to evaluating requirement in table 2,
Sensory review's test is carried out to each money tea-drinking, test table data are evaluated in effective 32 parts of collection, to soup look, fragrance, flavour, entirety
Four average marks of key factor total score carry out statistical analysis.
The granular pattern ginseng jujube kernel health preserving tea of table 2 evaluates table
From table 2 it can be seen that granular pattern ginseng jujube kernel health preserving tea contrast ginseng jujube kernel health bag obtained by embodiment 1,2,3
Make tea, tea perfume more fresh natural, mouthfeel is full abundant, color is yellowish green bright, granular pattern ginseng jujube kernel obtained by embodiment 1,2,3
Fraction will be apparently higher than conventional tea bag in three indexs of fragrance and flavour and color for health preserving tea, and its final score is 87
More than point, and the ginseng jujube kernel life-nourishing tea bag final score of routine is 76.
2nd, the benefiting qi for tranquillization sleeping effect test and appraisal of health preserving tea
The ginseng jujube kernel health bag bubble of granular pattern ginseng jujube kernel health preserving tea and routine obtained in the embodiment 1-3 that will be prepared
Tea be respectively issued to 100 insomniacs (100 insomniacs have a difficulty falling asleep, after-tax easily to wake up, and secondary morning feels dizzy, drowsiness,
The symptoms such as lassitude, fatigue and asthenia) use, 100 insomniacs take granular pattern ginseng jujube kernel health preserving tea according to identical
Method, drinks daily, continuously drinks three months.Every group of embodiment has 25 insomniacs to drink, insomniac according to oneself
Sensation scores sleep state and weak improvement situation, and scoring uses ten point system, and 1 point is worst, and 5 points moderate, 10 points
For best, score more high effect is better, and sleep quality improves to be included falling asleep easily, is difficult to wake up with a start after sleeping, full of energy after wakeing up；
Weak improvement situation includes that four limbs are strong, and the tired sense of body disappears；Using effect evaluation result such as table 3.
The embodiment 1-3 test results of table 3
The granular pattern ginseng jujube kernel health preserving tea that tester drinks embodiment of the present invention 1-3 is can be seen that by data in upper table
Afterwards, there is preferably improvement relative to comparative example (conventional ginseng jujube kernel life-nourishing tea bag), its sleep state and weak situation,
It is embodied in sleep easy, is difficult to wake up with a start after sleeping, full of energy after wakeing up, four limbs are strong, the tired sense of body disappears.Especially, it is real
The formula rate of example 1 is applied, it improves the health care of sleep quality and weak situation best results, and average is more than 8.5.It can be seen that, this
Its tonifying Qi and blood of the tea side of invention, relieving mental strain and helping sleep effect is preferable；It is main that each taste Chinese herbal medicine in tea side is taken into full account by the present invention
Difference of the active component in species, structure, physicochemical property on the basis of, said extracted technique is optimized, to
While reducing consumption, drug effect is significantly improved, make the formula that there is excellent tonifying Qi and blood, relieving mental strain and helping sleep effect.
3rd, the measure that health preserving tea release influences on liquor color, fragrance, flavour, overall quality
Method of testing is as follows, by the embodiment 1-3 of preparation and granular pattern ginseng jujube kernel is supported obtained in comparative example 1-3
Raw tea 200g adds 1600ml warm water (37 DEG C), respectively with 0.5 hour, 1 hour, 2 hours, 4 hours sampling 100ml, gives respectively
Six people are drunk, and everyone evaluates health preserving tea when 0.5 hour, 1 hour, 2 hours, 4 hours are drunk in each stage respectively
In the soup look of tea, fragrance, flavour, overall four key factors are evaluated.Effect assessment result such as table 4.
The test result of the embodiment 1 of table 4 and comparative example 1-3
Granular pattern ginseng jujube kernel health preserving tea of the invention can about discharge completely in four hours or so drug effect, and from
Data are visible in table, the granular pattern ginseng jujube kernel health preserving tea of embodiment 1 its soup look, fragrance, flavour and whole within four hours
From the point of view of body-sensing, scoring very high is respectively provided with, illustrates granular pattern ginseng jujube kernel health preserving tea insoluble drug release within four hours
Speed ratio relatively relax, in this granular pattern ginseng jujube kernel health preserving tea, because half raw material is made meal, second half extract effectively into
Point, meal active ingredient in immersion is not easy to discharge, and it is extracted after thick paste its active ingredient it is high, easily release
Out, therefore in immersion early stage, come from the thick paste of extraction the dark brown of millet paste, fragrance, flavour more, and later stage millet paste it is dark brown,
Come from the slow release of meal more fragrance, flavour, make tea perfume more fresh natural, mouthfeel is full abundant, color is yellowish green bright, four
Individual hour does not change, accordingly, with respect to existing tea bag for, overcome after existing tea bag only soaks once, tea flavour is big
Discounted defect.
The thick paste of comparative example 1-2 and embodiment 1：Hydroxypropyl methyl cellulose：Disintegrant：The composition phase of lubricant
Together, preparation method is identical, difference be the hydroxypropyl methyl cellulose consumption the present invention preferably consumption 0.2-0.6 with
Outward, i.e., respectively 0.1 and 0.7；Hydroxypropyl methyl cellulose rises as hydrogel matrix tablet slow-release material, the release to tea flavour
To certain effect that slows down, but inventor has found, also its is heavy to the release of whole tea side for the consumption of hydroxypropyl methyl cellulose
The effect wanted, is not the function of the release that arbitrarily addition can play fine control tea flavour, from data, comparative example
The granular pattern ginseng jujube kernel health preserving tea of 1-2, can not from the point of view of its soup look, fragrance, flavour and overall feeling in four hours
Stably discharge, can only be in preferable amount (0.2-0.6), its effect is only relatively good.
Comparative example 3 and the thick paste of embodiment 1：Hydroxypropyl methyl cellulose：Disintegrant：The usage ratio of lubricant is
1：0.3:0.06:0.03 usage ratio is identical, and preparation method is identical, difference be disintegrant by the present invention preferably PVP k,
Microcrystalline cellulose changes general conventional sodium carboxymethyl starch into, as a result finds, its disintegration effect is unsatisfactory, shows as making tea flavour
Rate of release substantially increases, and soup look and fragrance are all discharged quickly, tea flavour is thickened, it is difficult to entrance.Further illustrate,
The key for looking good, smell good and taste good of health preserving tea of the present invention is achieved in the selection of disintegrant of the invention and the distribution of consumption, matches somebody with somebody this
Side has excellent slow release effect.
It will be apparent to those skilled in the art that technical scheme that can be as described above and design, make other various
It is corresponding to change and deformation, and all these change and deformation should all belong to the protection domain of the claims in the present invention
Within.
Claims (10)
1. the preparation method of granular pattern ginseng jujube kernel health preserving tea, it is characterised in that specific preparation method comprises the following steps：
(1) the raw material Chinese herbal medicine of ginseng jujube kernel health preserving tea is prepared according to formula ratio；
(2) half of each raw material Chinese herbal medicine is ground into meal, and second half is by being extracted into thick paste；Then meal and thick paste be again
Mixing；
(3) to adding pharmaceutically acceptable auxiliary material, softwood processed in the mixture of meal and thick paste；Then it is made circular or bar
Shape or special-shaped bulky grain, through drying, particle surface of polishing obtains final product granular pattern ginseng jujube kernel health preserving tea.
2. the preparation method of granular pattern ginseng jujube kernel health preserving tea according to claim 1, it is characterised in that the ginseng jujube
Benevolence health preserving tea is made up of the component of following parts by weight：Ginseng 20-30 parts, jujube kernel 10-15 parts, sealwort 10-15 parts, Poria cocos 10-
15 parts, radix polygonati officinalis 10-15 parts, balsam pear 5-10 parts, balloonflower root 5-10 parts；
The extraction process of the step (2) is as follows：
(2.1) ginseng, jujube kernel, balloonflower root extract total saposins using the method for refluxing extraction；
(2.2) sealwort, Poria cocos, radix polygonati officinalis extract plant polyose using water extraction and alcohol precipitation method；
(2.3) balsam pear extracts Bitter Melon P.E using ultrasonic extraction.
3. the preparation method of granular pattern ginseng jujube kernel health preserving tea according to claim 2, it is characterised in that the step
(2.1) reflux extraction method of total saposins is as follows in：Take ginseng, jujube kernel, balloonflower root and be ground into meal, petroleum ether degreasing 3 times, every time
600ml, after with 70% ethanol 500mL refluxing extractions 3 times, Extracting temperature is 70 DEG C, every time one hour；Merge extract solution, reclaim
Ethanol, must dry to the medicinal extract of constant weight；Medicinal extract uses purification with macroreticular resin total saposins, takes wet resin, and blade diameter length ratio is 1:20,
Use 70% ethanol elution, flow velocity to be 2BV/h, collect eluent, after reclaiming ethanol, concentrate drying obtains final product ginseng, jujube kernel and tangerine
The total saposins of stalk.
4. the preparation method of granular pattern ginseng jujube kernel health preserving tea according to claim 3, it is characterised in that the macropore is inhaled
Attached resin is the one kind in AB-8, NKA-9, HPD-100, D-101, D-301, X-5.
5. the preparation method of granular pattern ginseng jujube kernel health preserving tea according to claim 3, it is characterised in that the eluent
Defoamer is added during concentrate drying, wherein thickening temperature is 65 DEG C, the concentration of defoamer is 0.05-0.08g/ml, wash-out
Liquid is (8-10) with the amount ratio of defoamer：1；The defoamer is silicone emulsion defoamer, 95% industrial alcohol, CL-259 doctors
One kind in medicine fermentation defoaming agent.
6. the preparation method of granular pattern ginseng jujube kernel health preserving tea according to claim 2, it is characterised in that the step
(2.2) extracting method of plant polyose is as follows in：Sealwort, Poria cocos, radix polygonati officinalis are added into 8 times of water of amount, 2-4h are extracted at 98-100 DEG C,
Filtering, the dregs of a decoction add 8 times of water of amount to extract 2-4h at 98-100 DEG C again, squeeze dregs of a decoction moisture to the greatest extent, and filtering, merging filtrate is concentrated into phase
When alcohol content up to 80% is made in crude drug 0.5g/mL, plus ethanol stirring, slow quickening is stirred, alcohol precipitation 24h, suction filtration, with 4 times of medicinal material bodies
The 95% ethanol washing precipitation of product weight, waves to 2 times without alcohol taste, be dissolved in water to medicinal material volume weight, adjusts pH to 8-9, plus
Enter anhydrous calcium chloride, make W/V up to 7%, dissolve, place room temperature, centrifugation takes supernatant concentration to thick paste, and 95 DEG C of drying under reduced pressure are
.
7. the preparation method of granular pattern ginseng jujube kernel health preserving tea according to claim 2, it is characterised in that the step
(2.3) ultrasonic extraction of balsam pear is as follows in：Balsam pear is ground into meal, is 350w in ultrasonic power, and Extracting temperature is 60 DEG C, is surpassed
Sound extraction time is 1h, and extract solution concentrate drying obtains final product Bitter Melon P.E.
8. the preparation method of granular pattern ginseng jujube kernel health preserving tea according to claim 2, it is characterised in that the step
(3) comprise the following steps that：
(3.1) it is total that the total saposins that extract meal and step (2.1)-(2.3), plant polyose, Bitter Melon P.E are mixed
Thick paste；
(3.2) auxiliary material hydroxypropyl methyl cellulose, PVP k, microcrystalline cellulose, magnesium stearate are taken, 100 mesh sieves is crossed respectively；
(3.3) total thick paste obtained in step (3.1)-(3.2) is taken, adds hydroxypropyl methyl cellulose tentatively to be mixed, then add
Enter disintegrant PVP k, microcrystalline cellulose, add appropriate 95% ethanol with softwood processed, cross the granulation of 4 mesh sieves, 45 DEG C to dry 1-3 small
When, then it is made circular or bar shaped or special-shaped bulky grain；Dried bulky grain is well mixed with magnesium stearate lubricant again, polishing
Large particle surface, you can slow-releasing granules type ginseng jujube kernel health preserving tea is obtained.
9. the preparation method of granular pattern ginseng jujube kernel health preserving tea according to claim 8, it is characterised in that the step
(3.3) total thick paste described in：Hydroxypropyl methyl cellulose：Disintegrant：The usage ratio of lubricant is 1：(0.2-0.6):0.06:
0.03；The disintegrant PVP k, the usage ratio of microcrystalline cellulose are (0.2-1):1.
10. a kind of granular pattern ginseng jujube kernel health preserving tea, it is characterised in that as the granular pattern as described in claim any one of 1-9
The preparation method of ginseng jujube kernel health preserving tea is prepared.
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| CN114010736A (en) * | 2021-12-24 | 2022-02-08 | 中国人民解放军空军军医大学 | Traditional Chinese medicine composition for regulating anxiety, depression and insomnia and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114010736A (en) * | 2021-12-24 | 2022-02-08 | 中国人民解放军空军军医大学 | Traditional Chinese medicine composition for regulating anxiety, depression and insomnia and preparation method thereof |
| CN114010736B (en) * | 2021-12-24 | 2023-06-02 | 中国人民解放军空军军医大学 | Application of traditional Chinese medicine composition in preparation of medicine for improving anxiety, depression and insomnia caused by non-alcoholic fatty liver |
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Application publication date: 20170623 |