CN111358824A - Preparation method of honeysuckle flower formula granules - Google Patents
Preparation method of honeysuckle flower formula granules Download PDFInfo
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- CN111358824A CN111358824A CN202010292864.0A CN202010292864A CN111358824A CN 111358824 A CN111358824 A CN 111358824A CN 202010292864 A CN202010292864 A CN 202010292864A CN 111358824 A CN111358824 A CN 111358824A
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- honeysuckle
- honeysuckle flower
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a preparation method of honeysuckle flower formula granules, which comprises the steps of raw material pretreatment, extraction, concentration, drying, granulation, screening, packaging and the like; the preparation method of the honeysuckle flower formula particle provided by the invention furthest retains the active ingredients in the traditional Chinese medicine honeysuckle, removes the bioactive-free ingredients in the raw medicinal materials, and avoids the tedious decoction work of a user, the method can realize the extraction of all the ingredients of the honeysuckle flower, the production is scientific, the quality is controllable, the large-scale production can be realized, and the honeysuckle flower formula particle has the advantages of convenience for taking, sanitation, convenience for storage and the like.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine formula granules, in particular to a preparation method of honeysuckle formula granules.
Background
The Chinese medicine prescription granule is a pure Chinese medicine series product which is prepared by taking traditional Chinese medicine decoction pieces which accord with processing specifications as raw materials through modern industrial extraction, concentration, drying, granulation and refinement, and the Chinese medicine prescription granule can be used as a new decoction piece form to replace the Chinese medicine decoction pieces for clinical treatment based on syndrome differentiation, addition and subtraction according to the symptoms and prescription. The Chinese medicinal formula granules realize high efficiency, safety, stability, controllability, convenience and sanitation of medication in clinical use. Because the traditional Chinese medicine formula granules have the characteristics of small dosage form, good curative effect, quick response, convenient taking, carrying and storage and the like, the traditional Chinese medicine formula granules are very suitable for the requirements of modern society including international society on natural medicines and the requirements of quick-paced life. Honeysuckle is a honeysuckle plant, a dried flower bud or a flower with early blossoming, is a common clinical traditional Chinese medicine, and has the effects of clearing away heat and toxic materials and cooling and dispelling wind-heat. Generally, a Chinese medicinal decoction is prepared by decocting the above herbs in water for administration. The main problem of the method is that different patients use different decocting methods for the same medicine, so that the decocting rates of the effective components of the medicine are greatly different, and the curative effect of the medicine is directly influenced; in addition, the common traditional Chinese medicine decoction is troublesome to decoct and can not be directly taken. Compared with the traditional Chinese medicine decoction, the honeysuckle flower formula granules can be taken after a patient takes the granules and dissolves the granules with water, the decoction step is omitted, and the granules remove the non-biological active ingredients in the raw medicinal materials, reduce the dosage and are convenient to store and transport.
Disclosure of Invention
The invention aims to provide a preparation method of honeysuckle flower formula granules, which aims to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme: a preparation method of honeysuckle flower formula granules comprises the following steps:
s1: pretreating raw materials, cleaning flos Lonicerae, screening to remove impurities, and pulverizing;
s2: extracting, namely extracting the honeysuckle processed in the step S1 to obtain a honeysuckle extracting solution;
s3: concentrating, namely concentrating the extracting solution obtained in the step S2 to obtain an extract;
s4: drying, namely performing spray drying on the extract obtained in the step S3 to obtain dry extract powder;
s5: granulating, namely granulating the dry extract powder obtained in the step S4 to obtain honeysuckle formula granules;
s6: screening, namely screening the formula particles obtained in the step S5 to remove particles with sizes not meeting the requirements;
s7: and (5) packaging, namely packaging the formula particles obtained in the step S6 in bags to obtain finished honeysuckle formula particles.
Preferably, the raw material pretreatment in step S1 specifically includes: cleaning the weighed honeysuckle raw materials in a traditional Chinese medicine cleaning machine, removing old stems and impurities, drying the cleaned raw materials in the air, drying and sterilizing the dried raw materials in a microwave dryer, and finally crushing the dried raw materials in a traditional Chinese medicine crusher.
Preferably, the specific steps extracted in step S2 are: adding 15-20 times of water by weight into the honeysuckle processed in the step S1, then heating, wherein the heating rate is 1-5 ℃/min, the extraction temperature is 63-77 ℃, extracting for 1-3 hours, and filtering out dregs to obtain a decoction; adding 15-20 times of water by weight of the raw material honeysuckle into the residues after the first decoction, and repeating the first decoction to finish the second decoction; mixing the two decoctions to obtain flos Lonicerae extractive solution.
Preferably, the concentration operation in step S3 specifically includes: concentrating the extractive solution under reduced pressure to obtain extract with relative density of 1.08-1.16, wherein the pressure of steam is controlled at 0.05-0.15MPa, the vacuum degree is controlled at-0.05-0.1 MPa, and the temperature is controlled at 25-30 deg.C.
Preferably, the process parameters of the spray drying in step S4 are as follows: the air inlet temperature is 160-174 ℃, and the air outlet temperature is 88-94 ℃.
Preferably, the granulation process in step S5 specifically includes: adding 3-7% of dextrin or lactose serving as an auxiliary material in parts by weight into the honeysuckle dry extract powder, and performing dry granulation to obtain the honeysuckle formula granules.
Preferably, the screening in step S6 includes the following steps: and (4) pouring the granules prepared in the step (S5) into a vibrating screen, firstly screening by using a 14-mesh sieve, and screening by using a 50-mesh sieve, wherein the granules which can pass through the 14-mesh sieve but can not pass through the 50-mesh sieve are qualified products.
Preferably, the step S7 specifically includes: and (4) performing quality inspection and weighing on the formula particles obtained in the step (S6), and then performing bag-by-bag packaging by using a particle packaging machine and a composite film, wherein the weight of each bag is controlled to be 9-11 g.
Preferably, the temperature rise rate in step S2 is preferably 2 ℃ to 3 ℃/min, preferably the extraction temperature is 68 ℃ to 72 ℃.
Has the advantages that: the invention has the beneficial effects that: the preparation method of the honeysuckle flower formula particle provided by the invention furthest retains the active ingredients in the traditional Chinese medicine honeysuckle, removes the bioactive-free ingredients in the raw medicinal materials, and avoids the tedious decoction work of a user, the method can realize the extraction of all the ingredients of the honeysuckle flower, the production is scientific, the quality is controllable, the large-scale production can be realized, and the honeysuckle flower formula particle has the advantages of convenience for taking, sanitation, convenience for storage and the like.
Detailed Description
The technical solution of the present patent will be described in further detail with reference to the following embodiments.
Example 1
The preparation method of the honeysuckle flower formula granule of the embodiment comprises the following steps:
s1: pretreating raw materials, putting the weighed honeysuckle raw materials into a traditional Chinese medicine cleaning machine for cleaning, removing old stems and impurities, airing the cleaned raw materials, putting the dried raw materials into a microwave dryer for drying and sterilizing, and finally putting the dried raw materials into a traditional Chinese medicine crusher for crushing.
S2: extracting, namely adding 15 times of water by weight into the honeysuckle processed in the step S1, heating, extracting for 1 hour at the temperature rising rate of 1 ℃/minute and the extraction temperature of 63 ℃, and filtering out residues to obtain first decoction; adding 15 weight parts of water into the residues after the first decoction, and repeating the first decoction to finish the second decoction; mixing the two decoctions to obtain flos Lonicerae extractive solution.
S3: concentrating, concentrating the extractive solution under reduced pressure to obtain extract with relative density of 1.08, wherein the pressure of steam is controlled at 0.05MPa, the vacuum degree is controlled at-0.05 MPa, and the temperature is controlled at 25 deg.C.
S4: and (5) drying, namely performing spray drying on the extract obtained in the step S3 to obtain dry extract powder, wherein the spray drying process parameters are as follows: the air inlet temperature is 160 ℃, and the air outlet temperature is 88 ℃.
S5: and (3) granulating, namely adding 3% of dextrin or lactose serving as an auxiliary material in parts by weight into the honeysuckle dry extract powder, and performing dry granulation to obtain the honeysuckle formula granules.
S6: and (4) screening, namely pouring the granules prepared in the step S5 into a vibrating screen, firstly screening by using a 14-mesh sieve, and screening by using a 50-mesh sieve, wherein the granules which can pass through the 14-mesh sieve but can not pass through the 50-mesh sieve are qualified products.
S7: and (4) packaging, namely performing quality inspection and weighing on the formula particles obtained in the step S6, and then performing bag packaging by using a particle packaging machine and a composite film, wherein the weight of each bag is controlled to be 9 g.
Example 2
The preparation method of the honeysuckle flower formula granule of the embodiment comprises the following steps:
s1: pretreating raw materials, putting the weighed honeysuckle raw materials into a traditional Chinese medicine cleaning machine for cleaning, removing old stems and impurities, airing the cleaned raw materials, putting the dried raw materials into a microwave dryer for drying and sterilizing, and finally putting the dried raw materials into a traditional Chinese medicine crusher for crushing.
S2: extracting, namely adding 17.5 times of water by weight into the honeysuckle processed in the step S1, heating, extracting for 2 hours at the temperature rising rate of 3 ℃/min and the extraction temperature of 70 ℃, and filtering out residues to obtain decoction; adding 17.5 times of water by weight of the raw material honeysuckle into the residues after the first decoction, and repeating the operation of the first decoction to finish the second decoction; mixing the two decoctions to obtain flos Lonicerae extractive solution.
S3: concentrating, concentrating the extractive solution under reduced pressure to obtain extract with relative density of 1.12, wherein the pressure of steam is controlled at 0.1MPa, the vacuum degree is controlled at 0.025MPa, and the temperature is controlled at 27.5 deg.C.
S4: and (5) drying, namely performing spray drying on the extract obtained in the step S3 to obtain dry extract powder, wherein the spray drying process parameters are as follows: the air inlet temperature is 167 ℃, and the air outlet temperature is 91 ℃.
S5: and (3) granulating, namely adding 5% of dextrin or lactose serving as an auxiliary material in parts by weight into the honeysuckle dry extract powder, and performing dry granulation to obtain the honeysuckle formula granules.
S6: and (4) screening, namely pouring the granules prepared in the step S5 into a vibrating screen, firstly screening by using a 14-mesh sieve, and screening by using a 50-mesh sieve, wherein the granules which can pass through the 14-mesh sieve but can not pass through the 50-mesh sieve are qualified products.
S7: and (4) packaging, namely performing quality inspection and weighing on the formula particles obtained in the step S6, and then performing bag packaging by using a particle packaging machine and a composite film, wherein the weight of each bag is controlled to be 10 g.
Example 3
The preparation method of the honeysuckle flower formula granule of the embodiment comprises the following steps:
s1: pretreating raw materials, putting the weighed honeysuckle raw materials into a traditional Chinese medicine cleaning machine for cleaning, removing old stems and impurities, airing the cleaned raw materials, putting the dried raw materials into a microwave dryer for drying and sterilizing, and finally putting the dried raw materials into a traditional Chinese medicine crusher for crushing.
S2: extracting, namely adding 20 times of water by weight into the honeysuckle processed in the step S1, heating, extracting for 3 hours at the temperature rising rate of 5 ℃/min and the extraction temperature of 77 ℃, and filtering out residues to obtain first decoction; adding 20 times of water by weight of the honeysuckle into the residues after the first decoction, and repeating the first decoction to finish the second decoction; mixing the two decoctions to obtain flos Lonicerae extractive solution.
S3: concentrating, concentrating the extractive solution under reduced pressure to obtain extract with relative density of 1.16, wherein the pressure of steam is controlled at 0.15MPa, the vacuum degree is controlled at 0.1MPa, and the temperature is controlled at 30 deg.C.
S4: and (5) drying, namely performing spray drying on the extract obtained in the step S3 to obtain dry extract powder, wherein the spray drying process parameters are as follows: the air inlet temperature is 174 ℃, and the air outlet temperature is 94 ℃.
S5: and (3) granulating, namely adding 7% of dextrin or lactose serving as an auxiliary material in parts by weight into the honeysuckle dry extract powder, and performing dry granulation to obtain the honeysuckle formula granules.
S6: and (4) screening, namely pouring the granules prepared in the step S5 into a vibrating screen, firstly screening by using a 14-mesh sieve, and screening by using a 50-mesh sieve, wherein the granules which can pass through the 14-mesh sieve but can not pass through the 50-mesh sieve are qualified products.
S7: and (4) packaging, namely performing quality inspection and weighing on the formula particles obtained in the step S6, and then performing bag packaging by using a particle packaging machine and a composite film, wherein the weight of each bag is controlled to be 11 g.
The preparation method of the honeysuckle flower formula particle provided by the invention furthest retains the active ingredients in the traditional Chinese medicine honeysuckle, removes the bioactive-free ingredients in the raw medicinal materials, and avoids the tedious decoction work of a user, the method can realize the extraction of all the ingredients of the honeysuckle flower, the production is scientific, the quality is controllable, the large-scale production can be realized, and the honeysuckle flower formula particle has the advantages of convenience for taking, sanitation, convenience for storage and the like.
The embodiments described above are preferred embodiments of the present invention, and not all embodiments. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (9)
1. A preparation method of honeysuckle flower formula granules is characterized by comprising the following steps:
s1: pretreating raw materials, cleaning flos Lonicerae, screening to remove impurities, and pulverizing;
s2: extracting, namely extracting the honeysuckle processed in the step S1 to obtain a honeysuckle extracting solution;
s3: concentrating, namely concentrating the extracting solution obtained in the step S2 to obtain an extract;
s4: drying, namely performing spray drying on the extract obtained in the step S3 to obtain dry extract powder;
s5: granulating, namely granulating the dry extract powder obtained in the step S4 to obtain honeysuckle formula granules;
s6: screening, namely screening the formula particles obtained in the step S5 to remove particles with sizes not meeting the requirements;
s7: and (5) packaging, namely packaging the formula particles obtained in the step S6 in bags to obtain finished honeysuckle formula particles.
2. The method for preparing honeysuckle flower formula particles according to claim 1, wherein the raw material pretreatment in step S1 specifically comprises: cleaning the weighed honeysuckle raw materials in a traditional Chinese medicine cleaning machine, removing old stems and impurities, drying the cleaned raw materials in the air, drying and sterilizing the dried raw materials in a microwave dryer, and finally crushing the dried raw materials in a traditional Chinese medicine crusher.
3. The method for preparing honeysuckle flower formula granules according to claim 1, wherein the specific steps of extraction in step S2 are as follows: adding 15-20 times of water by weight into the honeysuckle processed in the step S1, then heating, wherein the heating rate is 1-5 ℃/min, the extraction temperature is 63-77 ℃, extracting for 1-3 hours, and filtering out dregs to obtain a decoction; adding 15-20 times of water by weight of the raw material honeysuckle into the residues after the first decoction, and repeating the first decoction to finish the second decoction; mixing the two decoctions to obtain flos Lonicerae extractive solution.
4. The method of claim 1, wherein the concentration step S3 specifically comprises: concentrating the extractive solution under reduced pressure to obtain extract with relative density of 1.08-1.16, wherein the pressure of steam is controlled at 0.05-0.15MPa, the vacuum degree is controlled at-0.05-0.1 MPa, and the temperature is controlled at 25-30 deg.C.
5. The method for preparing honeysuckle flower formula particles according to claim 1, wherein the spray drying process parameters in step S4 are as follows: the air inlet temperature is 160-174 ℃, and the air outlet temperature is 88-94 ℃.
6. The method for preparing honeysuckle flower formula granules according to claim 1, wherein the granulating process in step S5 specifically comprises: adding 3-7% of dextrin or lactose serving as an auxiliary material in parts by weight into the honeysuckle dry extract powder, and performing dry granulation to obtain the honeysuckle formula granules.
7. The method for preparing honeysuckle flower formula granules according to claim 1, wherein the screening in step S6 comprises the following steps: and (4) pouring the granules prepared in the step (S5) into a vibrating screen, firstly screening by using a 14-mesh sieve, and screening by using a 50-mesh sieve, wherein the granules which can pass through the 14-mesh sieve but can not pass through the 50-mesh sieve are qualified products.
8. The method for preparing honeysuckle flower formula granules according to claim 1, wherein the step S7 of preserving specifically comprises the steps of: and (4) performing quality inspection and weighing on the formula particles obtained in the step (S6), and then performing bag-by-bag packaging by using a particle packaging machine and a composite film, wherein the weight of each bag is controlled to be 9-11 g.
9. A process for the preparation of a honeysuckle flower formulation granule according to claim 3, wherein the temperature rise rate is preferably between 2 ℃ and 3 ℃/min, preferably the extraction temperature is between 68 ℃ and 72 ℃.
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| CN202010292864.0A CN111358824A (en) | 2020-04-08 | 2020-04-08 | Preparation method of honeysuckle flower formula granules |
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| CN202010292864.0A CN111358824A (en) | 2020-04-08 | 2020-04-08 | Preparation method of honeysuckle flower formula granules |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115212244A (en) * | 2022-07-28 | 2022-10-21 | 黑龙江中医药大学 | Honeysuckle formula particle prescription and preparation process thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396417A (en) * | 2007-09-28 | 2009-04-01 | 未名天人中药有限公司 | Honeysuckle dispensing granule and preparation method and quality control method thereof |
| CN104127471A (en) * | 2014-07-31 | 2014-11-05 | 安徽济人药业有限公司 | Preparation method and quality control method for honeysuckle flower formula granule |
| CN109464509A (en) * | 2019-01-07 | 2019-03-15 | 浙江工业大学 | A kind of preparation method of Dan peach kernel granule |
| CN109568371A (en) * | 2018-02-06 | 2019-04-05 | 广东方制药有限公司 | A kind of preparation method of honeysuckle dispensing granule |
-
2020
- 2020-04-08 CN CN202010292864.0A patent/CN111358824A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101396417A (en) * | 2007-09-28 | 2009-04-01 | 未名天人中药有限公司 | Honeysuckle dispensing granule and preparation method and quality control method thereof |
| CN104127471A (en) * | 2014-07-31 | 2014-11-05 | 安徽济人药业有限公司 | Preparation method and quality control method for honeysuckle flower formula granule |
| CN109568371A (en) * | 2018-02-06 | 2019-04-05 | 广东方制药有限公司 | A kind of preparation method of honeysuckle dispensing granule |
| CN109464509A (en) * | 2019-01-07 | 2019-03-15 | 浙江工业大学 | A kind of preparation method of Dan peach kernel granule |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115212244A (en) * | 2022-07-28 | 2022-10-21 | 黑龙江中医药大学 | Honeysuckle formula particle prescription and preparation process thereof |
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Application publication date: 20200703 |