CN107115378A - One kind is relieved the effect of alcohol the flower granule and preparation method thereof of lipid-loweringing five - Google Patents
One kind is relieved the effect of alcohol the flower granule and preparation method thereof of lipid-loweringing five Download PDFInfo
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- CN107115378A CN107115378A CN201710467287.2A CN201710467287A CN107115378A CN 107115378 A CN107115378 A CN 107115378A CN 201710467287 A CN201710467287 A CN 201710467287A CN 107115378 A CN107115378 A CN 107115378A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1658—Proteins, e.g. albumin, gelatin
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention disclose one kind relieve the effect of alcohol lipid-loweringing five spend granule, it is in parts by weight, composed of the following components：Five 10 40 parts of thick pastes of flower, 5 40 parts of lactose, 5 40 parts of mannitol, 0.02 5 parts of protein sugar, 80 95% appropriate amount of ethanol.Compared with prior art, one kind of the invention relieve the effect of alcohol the flower granule of lipid-loweringing five have relieve the effect of alcohol, lipid-loweringing, it is clearing heat and detoxicating, the effect of replenish qi to invigorate the spleen；The preparation method of granule is spent in a kind of lipid-loweringing five of relieving the effect of alcohol of the present invention, and selection lactose and mannitol are filler, and grain forming is good, be difficult the moisture absorption, while compatibility protein sugar makes, particle mouthfeel is good, do not have any influence to diabetes and fat personnel.
Description
Technical field
The present invention relates to a kind of health care product formulation and its method of quality control, more particularly to one kind is relieved the effect of alcohol lipid-loweringing five
Flower granule and preparation method thereof.
Background technology
Chrysanthemum plays the role of scattered wind heat-clearing, flat liver improving eyesight in chrysanthemum, honeysuckle, flower of kudzuvine, Flos Semen Lablab Album, sophora flower；Honeysuckle
Have with clearing heat and detoxicating, clearing and activating the channels and collaterals effect；Flower of kudzuvine have it is potent relieve the effect of alcohol, also with heat-clearing, removing toxic substances, protect liver, beauty treatment, benefit
The effect of kidney；Flos Semen Lablab Album has the effect of anti-inflammation, lipid-loweringing, invigorating the spleen for eliminating dampness；There is sophora flower cooling blood and hemostasis, lipid-loweringing, clearing liver to rush down
Effect.
At present, granule is used, carried, storing convenient, can also change the bitter taste of traditional decoction, people are happy to use.
But, it there are problems that in Chinese herbal granules preparation method, such as traditional excipient more problems, such as sucrose is easily inhaled
Tide, makes the granule produced unstable, and the personnel such as diabetes, obesity, carious tooth should not take；Dextrin and starch rush molten
Property is poor；The problems such as flavouring has side effect.
The content of the invention
The flower granule of lipid-loweringing five and its preparation side in view of the above-mentioned problems of the prior art, present invention offer one kind is relieved the effect of alcohol
Method, with relieving the effect of alcohol, lipid-loweringing, it is clearing heat and detoxicating, the effect of replenish qi to invigorate the spleen.
In order to solve the above-mentioned technical problem, the present invention is adopted the following technical scheme that：One kind relieve the effect of alcohol lipid-loweringing five flower granule, its
It is characterised by, it is in parts by weight, composed of the following components：Five 5-40 parts of thick pastes of flower, 5-40 parts of lactose, 5-40 parts of mannitol, egg
0.02-5 parts of white sugar, 80-95% appropriate amount of ethanol.
One kind relieve the effect of alcohol lipid-loweringing five flower granule, it is in parts by weight, composed of the following components：Five 20 parts of thick pastes of flower, lactose 20
Part, 20 parts of mannitol, 0.03 part of protein sugar, 80-95% appropriate amount of ethanol.
As the further optimization of such scheme, described five spend the mass ratio of thick paste, lactose, mannitol and protein sugar to be 1:
0.5-2：0.5-2：0.01-0.5.
As the further optimization of such scheme, described five spend the mass ratio of thick paste, lactose, mannitol and protein sugar to be 1:
1：1：0.03.
As the further optimization of such scheme, the five flowers thick paste is in parts by weight, composed of the following components：Chrysanthemum 5-
30 parts, 5-30 parts of honeysuckle, 5-30 parts of flower of kudzuvine, 5-30 parts of Flos Semen Lablab Album, 5-30 parts of sophora flower.
As the further optimization of such scheme, the five flowers thick paste is in parts by weight, composed of the following components：Chrysanthemum 16
Part, 21 parts of honeysuckle, 12 parts of flower of kudzuvine, 13 parts of Flos Semen Lablab Album, 24 parts of sophora flower.
As the further optimization of such scheme, the preparation method of the five flowers thick paste comprises the following steps：
(61) extract：Chrysanthemum, honeysuckle, flower of kudzuvine, Flos Semen Lablab Album, sophora flower mixing and water adding are extracted into 2- under conditions of 85 DEG C
3 times, add 4-20 times each time and measure water, extract 30-120 minutes, filter respectively, merging filtrate each time；
(62) concentrate：The filtrate that step (61) is obtained is concentrated into density for 1.15-1.35kg/m3Filtrate；
(63) the heavy concentration of water：The filtrate that step (62) is obtained, it is heavy by water, it is concentrated into 1.20-1.35kg/m3Five flowers
Thick paste.
The invention also discloses the preparation method that granule is spent in a kind of lipid-loweringing five of relieving the effect of alcohol, comprise the following steps：
(71) five flower thick pastes, lactose, mannitol and protein sugar mixing are taken, ethanol mixing is added, softwood is made；
(72) softwood for obtaining step (71) crosses 12-24 mesh sieves, granulation；
(73) particle for obtaining step (72), under conditions of 40-85 DEG C, is dried；Obtain that water content is 1-5%
Grain；
(74) particle of step (73) is crossed into 60-80 mesh sieves, whole grain produces five flower granules.
As the further optimization of such scheme, by five flower granules by every bag of 3-15 grams of loading pouch, get product.
Compared with the prior art, the beneficial effect body of a kind of flower granule of lipid-loweringing five and preparation method thereof that relieves the effect of alcohol of the invention
Now：
(1) one kind of the invention is relieved the effect of alcohol the flower granule of lipid-loweringing five, by chrysanthemum, honeysuckle, flower of kudzuvine, Flos Semen Lablab Album, sophora flower, breast
Health care granule is made in sugar, mannitol compatibility, extraction again, available for relieving the effect of alcohol, lipid-loweringing, various excessive internal heats, constipation, has blood in stool；Enhancing machine
Body immunity.
(2) one kind of the invention is relieved the effect of alcohol the flower granule of lipid-loweringing five, and selection lactose and mannitol are filler, in addition, in compatibility
Protein sugar makes that particle mouthfeel is good, do not have any influence to diabetes and fat personnel.
(3) preparation method of granule is spent in a kind of lipid-loweringing five of relieving the effect of alcohol of the invention, and selection lactose and mannitol are filler,
Grain forming is good, be difficult the moisture absorption, while compatibility protein sugar makes, particle mouthfeel is good, do not have any shadow to diabetes and fat personnel
Ring.
(4) preparation method of granule is spent in a kind of lipid-loweringing five of relieving the effect of alcohol of the invention, and technique is easy to standardize, is adapted on a large scale
Production.To improving Competitive Products, effectively extend volume growth, promote interprise's intensive management and technological progress etc. all to have
Major and immediate significance and social effect.
Embodiment
To make the object, technical solutions and advantages of the present invention of greater clarity, below by embodiment, the present invention is entered
Row is further described.However, it should be understood that the specific embodiments described herein are merely illustrative of the present invention, and without
In limitation the scope of the present invention.
Embodiment 1
One kind relieve the effect of alcohol lipid-loweringing five flower granule, it is in parts by weight, composed of the following components：Five flower 5 parts of thick pastes, 5 parts of lactose,
5 parts of mannitol, 0.02 part of protein sugar, 80-95% appropriate amount of ethanol.
Wherein, the five flowers thick paste is in parts by weight, composed of the following components：5-30 parts of chrysanthemum, 5-30 parts of honeysuckle, Pueraria lobota
5-30 parts of flower, 5-30 parts of Flos Semen Lablab Album, 5-30 parts of sophora flower.
And the preparation method of the five flowers thick paste, comprise the following steps：
(61) extract：Chrysanthemum, honeysuckle, flower of kudzuvine, Flos Semen Lablab Album, sophora flower mixing and water adding are extracted 2 under conditions of 85 DEG C
It is secondary, 10 times of amount water are added for the first time, 15 times of amount water are added for the second time, extraction 60 minutes, are filtered, merging filtrate respectively each time；
(62) concentrate：The filtrate that step (61) is obtained is concentrated into density for 1.15-1.35kg/m3Filtrate；
(63) the heavy concentration of water：The filtrate that step (62) is obtained, it is heavy by water, it is concentrated into 1.20-1.35kg/m3Five flowers
Thick paste.
One kind of this preferred embodiments relieve the effect of alcohol lipid-loweringing five flower granule, comprise the following steps：
(71) five flower thick pastes, lactose, mannitol and protein sugar mixing are taken, ethanol mixing is added, softwood is made；
(72) softwood for obtaining step (71) crosses 12-24 mesh sieves, granulation；
(73) particle for obtaining step (72), under conditions of 40-85 DEG C, is dried；Obtain that water content is 1-5%
Grain；
(74) particle of step (73) is crossed into 60-80 mesh sieves, whole grain produces five flower granules；
(75) five flower granules are got product by every bag of 3-15 grams of loading pouch.
Embodiment 2
One kind relieve the effect of alcohol lipid-loweringing five flower granule, it is in parts by weight, composed of the following components：Five 20 parts of thick pastes of flower, lactose 20
Part, 20 parts of mannitol, 0.03 part of protein sugar, 80-95% appropriate amount of ethanol.
Wherein, the five flowers thick paste is in parts by weight, composed of the following components：20 parts of chrysanthemum, 20 parts of honeysuckle, flower of kudzuvine 20
Part, 20 parts of Flos Semen Lablab Album, 20 parts of sophora flower.
And the preparation method of the five flowers thick paste, comprise the following steps：
(61) extract：Chrysanthemum, honeysuckle, flower of kudzuvine, Flos Semen Lablab Album, sophora flower mixing and water adding are extracted 2 under conditions of 85 DEG C
It is secondary, 10 times of amount water are added for the first time, 8 times of amount water are added for the second time, extraction 60 minutes, are filtered, merging filtrate respectively each time；
(62) concentrate：The filtrate that step (61) is obtained is concentrated into density for 1.15-1.35kg/m3Filtrate；
(63) the heavy concentration of water：The filtrate that step (62) is obtained, it is heavy by water, it is concentrated into 1.20-1.35kg/m3Five flowers
Thick paste.
One kind of this preferred embodiments relieve the effect of alcohol lipid-loweringing five flower granule, comprise the following steps：
(71) five flower thick pastes, lactose, mannitol and protein sugar are taken according to mixing, ethanol mixing is added, softwood is made；
(72) softwood for obtaining step (71) crosses 12-24 mesh sieves, granulation；
(73) particle for obtaining step (72), under conditions of 40-85 DEG C, is dried；Obtain that water content is 1-5%
Grain；
(74) particle of step (73) is crossed into 60-80 mesh sieves, whole grain produces five flower granules；
(75) five flower granules are got product by every bag of 10 grams of loading pouches.
Embodiment 3
One kind relieve the effect of alcohol lipid-loweringing five flower granule, it is in parts by weight, composed of the following components：Five 40 parts of thick pastes of flower, lactose 40
Part, 40 parts of mannitol, 5 parts of protein sugar, 80-95% appropriate amount of ethanol.
Wherein, the five flowers thick paste is in parts by weight, composed of the following components：16 parts of chrysanthemum, 21 parts of honeysuckle, flower of kudzuvine 12
Part, 13 parts of Flos Semen Lablab Album, 24 parts of sophora flower.
And the preparation method of the five flowers thick paste, comprise the following steps：
(61) extract：Chrysanthemum, honeysuckle, flower of kudzuvine, Flos Semen Lablab Album, sophora flower mixing and water adding are extracted 3 under conditions of 85 DEG C
It is secondary, add 10 times to measure water for the first time, 8 times of amount water are added for the second time, 6 times are added for the second time and measures water, each time extraction 60 minutes, respectively mistake
Filter, merging filtrate；
(62) concentrate：The filtrate that step (61) is obtained is concentrated into density for 1.15-1.35kg/m3Filtrate；
(63) the heavy concentration of water：The filtrate that step (62) is obtained, it is heavy by water, it is concentrated into 1.20-1.35kg/m3Five flowers
Thick paste.
One kind of this preferred embodiments relieve the effect of alcohol lipid-loweringing five flower granule, comprise the following steps：
(71) five flower thick pastes, lactose, mannitol and protein sugar are taken according to mixing, ethanol mixing is added, softwood is made；
(72) softwood for obtaining step (71) crosses 12-24 mesh sieves, granulation；
(73) particle for obtaining step (72), under conditions of 40-85 DEG C, is dried；Obtain that water content is 1-5%
Grain；
(74) particle of step (73) is crossed into 60-80 mesh sieves, whole grain produces five flower granules；
(75) five flower granules are got product by every bag of 10 grams of loading pouches.
The present invention one kind relieve the effect of alcohol lipid-loweringing five flower granule, by chrysanthemum, honeysuckle, flower of kudzuvine, Flos Semen Lablab Album, sophora flower, lactose,
Health care granule is made in mannitol compatibility, extraction, available for relieving the effect of alcohol, lipid-loweringing, various excessive internal heats, constipation, has blood in stool；Strengthen immunity of organism
Power.The preparation method of granule is spent in a kind of lipid-loweringing five of relieving the effect of alcohol of the present invention, and selection lactose and mannitol are filler, grain forming
Property it is good, be difficult the moisture absorption, while compatibility protein sugar makes, particle mouthfeel is good, do not have any influence to diabetes and fat personnel.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
Any modification, equivalent substitution or improvement made within refreshing and principle etc., should be included in the scope of the protection.
Claims (9)
1. one kind is relieved the effect of alcohol, granule is spent in lipid-loweringing five, it is characterised in that in parts by weight, composed of the following components：Five flower thick paste 10-
40 parts, 5-40 parts of lactose, 5-40 parts of mannitol, 0.02-5 parts of protein sugar, 80-95% appropriate amount of ethanol.
2. one kind is relieved the effect of alcohol, granule is spent in lipid-loweringing five, it is characterised in that in parts by weight, composed of the following components：Five flower thick pastes 20
Part, 20 parts of lactose, 20 parts of mannitol, 0.03 part of protein sugar, 80-95% appropriate amount of ethanol.
3. one kind according to claim 1 is relieved the effect of alcohol, granule is spent in lipid-loweringing five, it is characterised in that：It is described five flower thick paste, lactose,
The mass ratio of mannitol and protein sugar is 1:0.5-2：0.5-2：0.01-0.5.
4. one kind according to claim 1 is relieved the effect of alcohol, granule is spent in lipid-loweringing five, it is characterised in that：It is described five flower thick paste, lactose,
The mass ratio of mannitol and protein sugar is 1:1：1：0.03.
5. one kind according to claim 1 is relieved the effect of alcohol, granule is spent in lipid-loweringing five, it is characterised in that：The five flowers thick paste is with weight
Part meter, it is composed of the following components：5-30 parts of chrysanthemum, 5-30 parts of honeysuckle, 5-30 parts of flower of kudzuvine, 5-30 parts of Flos Semen Lablab Album, sophora flower 5-
30 parts.
6. one kind according to claim 1 is relieved the effect of alcohol, granule is spent in lipid-loweringing five, it is characterised in that：The five flowers thick paste is with weight
Part meter, it is composed of the following components：16 parts of chrysanthemum, 21 parts of honeysuckle, 12 parts of flower of kudzuvine, 13 parts of Flos Semen Lablab Album, 24 parts of sophora flower.
7. one kind according to claim 4 or 5 is relieved the effect of alcohol, granule is spent in lipid-loweringing five, it is characterised in that：The five flowers thick paste
Preparation method, comprises the following steps：
(61) extract：Chrysanthemum, honeysuckle, flower of kudzuvine, Flos Semen Lablab Album, sophora flower mixing and water adding are extracted 2-3 times under conditions of 85 DEG C,
Each time plus 4-20 times is measured water, extract 30-120 minutes, filter respectively, merging filtrate each time；
(62) concentrate：The filtrate that step (61) is obtained is concentrated into density for 1.15-1.35kg/m3Filtrate；
(63) the heavy concentration of water：The filtrate that step (62) is obtained, it is heavy by water, it is concentrated into 1.20-1.35kg/m3Five flower thick pastes.
8. the preparation method of granule is spent based on a kind of any described lipid-loweringings five of relieving the effect of alcohol of claim 1-7, it is characterised in that, bag
Include following steps：
(71) five flower thick pastes, lactose, mannitol and protein sugar mixing are taken, ethanol mixing is added, softwood is made；
(72) softwood for obtaining step (71) crosses 12-24 mesh sieves, granulation；
(73) particle for obtaining step (72), under conditions of 40-85 DEG C, is dried；Obtain the particle that water content is 1-5%；
(74) particle of step (73) is crossed into 60-80 mesh sieves, whole grain produces five flower granules.
9. the preparation method of granule is spent in a kind of lipid-loweringing five of relieving the effect of alcohol according to claim 8, it is characterised in that：By five flowers
Granula is got product by every bag of 10 grams of loading pouches.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464509A (en) * | 2019-01-07 | 2019-03-15 | 浙江工业大学 | Preparation method of blanched peach seed formula granules |
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