CN105664018A

CN105664018A - Cholagogue and lithagogue tablets and preparation method thereof

Info

Publication number: CN105664018A
Application number: CN201610051119.0A
Authority: CN
Inventors: 韩志强
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-26
Filing date: 2016-01-26
Publication date: 2016-06-15

Abstract

The invention discloses cholagogue and lithagogue tablets and a preparation method thereof. The cholagogue and lithagogue tablets are prepared from longhairy antenoron herbs, virgate wormwood herbs, baical skullcap roots, costus roots, turmeric root-tuber, rhubarb, areca nuts, immature bitter orange stir-fried with bran, mirabilite, ginger stir-fried magnolia officinalis bark, cross-linked polyvinylpolypyrrolidone, sodium carboxymethyl starch and croscarmellose sodium. The preparation method of the cholagogue and lithagogue tablets is implemented as follows: 1/2 of longhairy antenoron herbs, 1/2 of virgate wormwood herbs, 1/2 of rhubarb, 1/2 of baical skullcap roots and 1/2 of mirabilite are ultramicroporwderized, the remaining longhairy antenoron herbs, the remaining virgate wormwood herbs and the areca nuts are extracted with a compound enzyme, and supercritical extraction is performed on other raw materials. The cholagogue and lithagogue tablets and the preparation method have the advantages that effective components are more sufficiently extracted with an improved process, the content is higher, the drug dissolving-out speed is high, the bioavailability is high, and the stability is good.

Description

A kind of cholagogic and lithagogue tablet and preparation method thereof

Technical field

The present invention relates to the pharmaceutical formulation of a kind of field of medicaments, particularly relate to a kind of cholagogic and lithagogue tablet and preparation method thereof.

Background technology

Cholagogic and lithagogue tablet is that Chinese Pharmacopoeia records kind. It is prepared from by Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Scutellariae, the Radix Aucklandiae, Radix Curcumae, Radix Et Rhizoma Rhei, Semen Arecae, Fructus Aurantii Immaturus (parched with bran), Natrii Sulfas and Cortex Magnoliae Officinalis(processed with ginger), there is effect of clearing away heat-damp and promoting diuresis, cholagogic and lithagogue, the hypochondriac pain accumulate caused by poison, FU QI being obstructed for damp and hot, gallbladder-distention, disease sees distending pain over the hypochondrium, heating, yellowish urine, constipation, cholecystitis, cholelithiasis etc.

Current cholagogic and lithagogue tablet preparation technology is substantially and continues to use Conventional processing methods, pulverizes the Radix Aucklandiae, Radix Et Rhizoma Rhei, Natrii Sulfas at fine powder; The seven flavor medicine boilings such as all the other Herba Lysimachiaes are extracted. Due to common grinder be open pulverizing can there is granulation time particle diameter big, heavy metal pollution can be caused, drug-eluting speed is slow, the shortcomings such as bioavailability is low. Due to mixed extraction or decoction, the active ingredient that can promote its single crude drug is unstable, and the extraction ratio of crude drug mixing decoction active ingredient also can be substantially reduced, and also inevitably proposes a large amount of water-solubility impurities. The content of the amount of the effect that traditional Chinese medicine disease prevention is cured the disease and extract and wherein effective ingredient has direct relation. If extraction process is unreasonable, not science, destruction and the loss of effective ingredient certainly will be caused, thus affecting the quality of preparation, curative effect. Additionally, the disintegration time of existing cholagogic and lithagogue tablet is longer, after long-term especially placement, having the phenomenon beyond standards of pharmacopoeia, the long meeting of disintegration time has a strong impact on the absorption of medicine.

Along with clinically to drug quality, the improving constantly and the development of pharmaceutical technology of effect requirements, this technique can not meet current demand, it is badly in need of the preparation process that a kind of extracts active ingredients is more complete, content is higher, to play the medical value of cholagogic and lithagogue tablet classics prescription better.

Summary of the invention

It is an object of the invention to for the deficiencies in the prior art, there is provided a kind of extracts active ingredients more completely, content is higher, drug-eluting speed is fast, bioavailability is high and the preparation technology of the cholagogic and lithagogue tablet of good stability, thus playing the medical value of this tradition proved recipe better.

Present invention aim at providing a kind of cholagogic and lithagogue tablet preparation.

Another object of the present invention is to the preparation method that a kind of cholagogic and lithagogue tablet is provided.

The present invention is achieved through the following technical solutions:

Cholagogic and lithagogue tablet of the present invention is made up of following crude drug and adjuvant:

Cholagogic and lithagogue tablet of the present invention is preferably as follows crude drug and adjuvant composition:

Cholagogic and lithagogue tablet of the present invention is it is also preferred that following crude drug and adjuvant form:

The present invention provides a kind of cholagogic and lithagogue tablet, and this cholagogic and lithagogue tablet is prepared from by following methods:

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, in micronizing, the grain size of micropowder of more than 85% is less than 8 microns, the Herba Lysimachiae of 1/2 amount water soaking 15-45 minute of 4-12 times amount under remainder, add 10-30 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, medicinal residues are again with soak by water 1-3 hour of 3-9 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount is added water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, medicinal residues with soak by water 1-2 hour of 3-9 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 20-60 order, superfine powder is placed on CO₂Soaking 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO₂Flow maintain 20-40Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas micropowders to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

The present invention provides a kind of cholagogic and lithagogue tablet, and this cholagogic and lithagogue tablet also can be prepared from by following methods:

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders;Micronizing process sprays into 50-150 weight portion dry ice as coolant, in micronizing, the grain size of micropowder of 85-99% is less than 6 microns, it is preferable that the grain size of micropowder 3-6 micron of 90-95% in micronizing, the Herba Lysimachiae of 1/2 amount water soaking 15-45 minute of 4-12 times amount under remainder, add 10-30 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, medicinal residues are again with soak by water 1-3 hour of 3-9 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount is added water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, medicinal residues with soak by water 1-2 hour of 3-9 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 20-60 order, superfine powder is placed on CO₂Soaking 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO₂Flow maintain 20-40Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas micropowders to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

The present invention provides a kind of cholagogic and lithagogue tablet, and the preferred following methods of this cholagogic and lithagogue tablet is prepared from:

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 100 weight portion dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns, it is preferable that the grain size of micropowder 3-6 micron of 90-95% in micronizing, the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20 weight portion compound enzymes, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30,The Herba Artemisiae Scopariae of remaining 1/2 amount adding the water soaking 30 minutes of 8 times amount, adds the compound enzyme of 20 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate; Medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30; Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40; By the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

The preparation method of cholagogic and lithagogue tablet of the present invention is: the Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 50-150 weight portion dry ice as coolant, in micronizing, the grain size of micropowder of 85-99% is less than 8 microns, it is preferable that the grain size of micropowder 3-6 micron of 90-95% in micronizing, the Herba Lysimachiae of 1/2 amount water soaking 15-45 minute of 4-12 times amount under remainder, add 10-30 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, medicinal residues are again with soak by water 1-3 hour of 3-9 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount is added water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, medicinal residues with soak by water 1-2 hour of 3-9 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35～1.40,By the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 20-60 order, superfine powder is placed on CO₂Soaking 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO₂Flow maintain 20-40Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas micropowders to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

The preparation method of cholagogic and lithagogue tablet of the present invention is preferably: the Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 100 weight portion dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns, it is preferable that the grain size of micropowder 3-6 micron of 90-95% in micronizing, the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20 weight portion compound enzymes, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adding the water soaking 30 minutes of 8 times amount, adds the compound enzyme of 20 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate, medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

Cholagogic and lithagogue tablet of the present invention is made up of following crude drug, adjuvant and preparation method:

Described weight portion is with g for unit of account;

Preparation method is:

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 100g dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns, it is preferable that the grain size of micropowder 3-6 micron of 90-95% in micronizing, the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adds the water soaking 30 minutes of 8 times amount, the compound enzyme of addition 20g, and described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate, medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet, every tablet weight 0.62g.

The cholagogic and lithagogue tablet of the present invention application in the medicine that the damp and hot hypochondriac pain accumulate caused by poison, FU QI being obstructed and gallbladder-distention, cholecystitis or cholelithiasis are treated in preparation.

The advantage of cholagogic and lithagogue tablet of the present invention is in that, by the Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively, chilled pretreatment before pulverizing, and in superfine powder, spray into dry ice as coolant, abrasive body can obtain effective cooling in very short time, makes pulverized Chinese crude drug reach the effect of micronizing in very short time and keep high biological activity. And the grain size of micropowder of micronizing is little, owing to micronizing process materials temperature is lower than-18 DEG C; Chinese crude drug superfine powder after micronizing, pollution-free, the heavy metal break flour microgranule such as Chrome-free, nickel, cadmium, titanium, ferrum, copper, zinc, lead, arsenic peels off and disengages.Another the remaining Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount and Semen Arecae are extracted with compound enzyme respectively, make its extracts active ingredients more completely, content is higher, stability is better, extract has been carried out purification by the method, curative effect there has also been with tradition technics comparing and significantly improves, and is also greatly reduced production cost; All the other crude drug carry out supercritical extraction so that its effective ingredient is not destroyed, and the active ingredient extracting medicine is more complete, and the dissolution height of medicine, drug effect retention time length and bioavailability are high. The present invention improve after technique also added appropriate disintegrating agent, tablet disintegration times made after adding disintegrating agent at about 12 minutes, the also complete disintegrate at about 17 minutes after accelerating to place 6 months. Effectively prevent disintegrate and cross the slow adverse effect that curative effect is caused.

Constantly there is the application in Chinese medicine extraction of people's studying enzyme in recent years, and achieve good effect. The present invention adopts this advanced technology, according to the character feature of crude drug effective ingredient, traditional decoction technique is optimized and is improved. Lot of experiments has been done in selection for enzyme class and consumption. Finally give the tablet that above-mentioned preparation method and this method prepare. Extract has been carried out purification by the method, when decreasing a large amount of impurity, the extract (extractum) obtained improves notable than traditional method, and effective ingredient also more former traditional handicraft is stable, curative effect being more also significantly increased with traditional handicraft, is also greatly reduced production cost.

Different crude drug, the enzyme and the consumption that are suitable for are not quite similar. The weak effect of enzymolysis when the consumption of enzyme is on the low side, along with the concentration of enzyme raises, increases with the contact area of substrate, and enzyme digestion reaction speed increases, but not more high more good, then can produce inhibitory action when enzyme reaches a certain concentration, and enzyme is not fully utilized, and causes waste. Therefore, kind and the consumption of enzyme have been investigated by inventor, it has been found that difference on effect is obvious. The compound enzyme best results wherein combined with the pectase of 2:2:1, papain and cellulase ratio, make the extracts active ingredients of Herba Lysimachiae, Herba Artemisiae Scopariae and Semen Arecae more completely, content is higher, stability is better, extract has been carried out purification by the method, and curative effect there has also been with tradition technics comparing and significantly improves.

The tablet being key component with Chinese medicine extract, owing to extract component is many and complicated oneself viscosity is higher, general disintegration time is all partially long, particularly long-term place after, the trend that disintegration time continues to extend is obvious. Therefore, the present invention with the addition of tablet disintegration times made after polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose at about 12 minutes, the also complete disintegrate at about 17 minutes after accelerating to place 6 months. Effectively prevent disintegrate and cross the slow adverse effect that curative effect is caused.

The present inventor investigates different process step and the parameter impact on Chinese medicinal tablet of the present invention by tests below.

Reiterate: tests below is the test of the illustrative in numerous tests in development process of the present invention, it is not covered by and is exhausted and invent all experiments that the artificial present invention does, only for purpose of partial routine and the result of setting forth Chinese medicinal tablet preparation method screening and optimizing of the present invention by those data.

Experimental example one:

1, the selection of disintegrating agent of the present invention

By the processing step (before being not added with adjuvant) of the invention process 1, disintegrating agent kind and consumption according to table 1 are screened.It is shown that polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose can substantially accelerate disintegration rate, particularly three with after the cooperation of 2:1:1 ratio, disintegration time significantly shortens. Refer to table 1.

The selection result of table 1 disintegrating agent

2, compare disintegration

2.1 medicament selection

Test sample 1 (preparing according to the embodiment of the present invention 1 method).

Test sample 2 (preparing according to the embodiment of the present invention 2 method)

Test sample 3 (prepared by present invention embodiment 3 method)

Reference substance 4 preparation method:

Above ten tastes, the Radix Aucklandiae, Radix Et Rhizoma Rhei, the seven taste boilings such as that mirabilite powder is broken into fine powder is standby, all the other Herba Lysimachiaes, filter, filtrate is concentrated in right amount, adds hydroxypropyl methyl cellulose 20g mixing with above-mentioned fine powder, granulates, and dries. Film coating sheet. Every tablet weight 0.31g.

2.2 disintegrations checked: adopt Rotating shaker, lift disintegration tester, took each 6 of test sample 1, test sample 2, test sample 3 and reference substance 4, observed the situation by screen cloth, and percent of pass height then disintegrative is good, more preferably absorption of human body. In Table 2

Table 2

Group	Accelerate to place in 1 month disintegration (min)	Accelerate to place 6-12 month disintegration (min)
			Test sample 1	12.05	16.21
Test sample 2	12.14	17.13
			Test sample 3	12.08	17.15
Reference substance 4	22.16	32.95

2.3 conclusions

By above-mentioned table 2 it is known that 1 month interior disintegration time is placed in the acceleration of test sample of the present invention 1,2 and 3

Respectively 12.05,12.14 and 12.08 minutes, accelerate to place 6-12 month disintegration time also at 16.21,17.13 and 17.15 minutes, and reference substance 4 acceleration 1 month interior disintegration time of placement is 22.16 minutes, accelerating to place 6-12 month disintegration time is 32.95 minutes, and the disintegration time of test sample 1,2 and 3 of the present invention compares with the disintegration time of reference substance 4 that there were significant differences.

3, Dissolution experiments

Test sample 1 (preparing according to the embodiment of the present invention 1 method) of the present invention, test sample 2 (preparing according to the embodiment of the present invention 2 method), test sample 3 (prepared by present invention embodiment 3 method), reference substance 4 (identical with the preparation method testing 2 reference substances 4) are carried out dissolution investigation, adopts the FDA similarity estimate recommended to evaluate its dissolution. Result is in Table 3

Table 3

Owing to the preparation method of test sample 1,2 and 3 of the present invention all adopts micronizing and supercritical extraction, its particle diameter is less than 6 microns (in preferred micronizing grain size of micropowder 3-6 microns of 90-95%), dissolution when 30 minutes is more than 91%, when 60 minutes, dissolution was more than 87%, and when 90 minutes, dissolution was more than 85%. And reference substance 4 adopts Ordinary pulverization method, its particle diameter is big, and not easily dissolution, therefore the dissolution when 30 minutes is 61%, and when 60 minutes, dissolution was 50%, and when 90 minutes, dissolution was 40%. The dissolution of test sample 1,2 and 3 of the present invention compares with the dissolution of reference substance 4 that there were significant differences.

4, stability experiment

Weigh test sample 1 (preparing according to the embodiment of the present invention 1 method) of the present invention, test sample 2 (preparing according to the embodiment of the present invention 2 method), test sample 3 (prepared by present invention embodiment 3 method), reference substance 4 (identical with the preparation method testing 2 reference substances 4) each 4g respectively, inject chromatograph of liquid, being measured at 0,2,4,12,24 months respectively, measurement result is as follows: in Table 4

Table 4

As seen from the above table, the stability of test sample 1,2 and 3 of the present invention is fine, after study on the stability 24 months, the content of its active ingredient is substantially unchanged, and reference substance 4 is after study on the stability 24 months, the content of its active ingredient has significant change, and illustrates that the stability of inventive test sample 1,2 and 3 is significantly better than reference substance 4.

5, drug effect compares

Add up the damp and hot hypochondriac pain accumulate caused by poison, FU QI being obstructed of 200 examples and gallbladder-distention, cholecystitis or Patients with Cholelithiasis, age is in 28-65 year, wherein 100 examples take matched group medicine (preparing according to experimental example 1 reference substance 4 method), another 100 example patients take of the present invention group of medicine (preparing according to the embodiment of the present invention 1 method), and instructions of taking and curative effect are as follows: in Table 5

Table 5

Group	Number	Day/time	Each serving consumption	Take natural law	Total effective rate
						Matched group	100 people	2 times	6 (0.31g/ sheet)	10	83%
Of the present invention group	100 people	2 times	3 (0.62g/ sheet)	10	97%

Conclusion: matched group is 83% at the total effective rate of the various hyperlipidemia for the treatment of, cerebrovascular sclerosis, Simple Obesity, habitual constipation and bleeding hemorrhoids 100 example patient, of the present invention group is 97% treating the total effective rate of the 100 example patients such as various hyperlipidemia, cerebrovascular sclerosis, Simple Obesity, habitual constipation and bleeding hemorrhoids, and the total effective rate of of the present invention group compares with matched group total effective rate that there were significant differences.

The screening experiment of experimental example two, enzyme class and consumption

1. the proportioning of enzyme or compound enzyme (enzyme class is in Table 6) and Herba Lysimachiae is: enzyme or compound enzyme 20g, Herba Lysimachiae 125g, take the water soaking 30 minutes of Herba Lysimachiae 8 times amount, add enzyme or compound enzyme, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum of 1.25-1.30,

Herba Lysimachiae is extracted according to said ratio and extracting method with 10 kinds of enzymes in table 6 or compound enzyme, the yield obvious difference extracted between different enzymes, wherein notable with pectase+papain+cellulase 2:2:1 compound enzyme effect coordinated, comparing with other kinds of enzyme, there were significant differences in yield raising. Refer to table 6.

The screening test result (Herba Lysimachiae) of table 6 enzyme class

Group number	Enzyme class	Herba Lysimachiae yield g	Herba Lysimachiae yield %
				1	Cellulase	22.1	17.7%
2	Pectase	26.6	21.3%
				3	Papain	30.4	24.3%
4	Neutral protease	29.4	23.5%
				5	Pectase+papain (2:2)	38.6	30.9%
6	Pectase+cellulase (2:1)	35.6	28.5%
				7	Papain+pectase+neutral protease (3:1:1)	30.6	24.5%
8	Papain+cellulase (2:1)	39.3	31.4%
				9	Pectase+papain+cellulase (1:1:1)	40.8	32.6%
10	Pectase+papain+cellulase (2:2:1)	70.4	56.3%

Screening test result according to table 6 enzyme class shows, group number 10 pectases+papain+cellulase (2:2:1) is the highest in the yield extracting Herba Lysimachiae, compare with other enzymes that there were significant differences, therefore compound enzyme preferred pectin enzyme+papain+cellulase (2:2:1).

2, the proportioning of enzyme or compound enzyme and Herba Artemisiae Scopariae is: enzyme or compound enzyme 20g, Herba Artemisiae Scopariae 125g; The Herba Artemisiae Scopariae of remaining 1/2 amount is added the water soaking 30 minutes of 8 times amount, adds enzyme or compound enzyme, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decoction 2 hours, filter to get filtrate; Medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum of 1.25-1.30;

Herba Artemisiae Scopariae is extracted according to said ratio and extracting method with 10 kinds of enzymes in table 7 or compound enzyme, the yield obvious difference extracted between different enzymes, the compound enzyme effect wherein coordinated with papain+pectase+neutral protease (3:1:1) is the most notable, comparing with other kinds of enzyme, there were significant differences in yield raising. Refer to table 7.

The screening test result (Herba Artemisiae Scopariae) of table 7 enzyme class

Group number	Enzyme class	Herba Artemisiae Scopariae yield g	Herba Artemisiae Scopariae yield %
				1	Cellulase	21	16.8%
2	Pectase	26.6	21.3%
				3	Papain	30.1	24.1%
4	Neutral protease	28.6	22.9%
				5	Pectase+papain (2:2)	38	30.4%
6	Pectase+cellulase (2:1)	34.9	27.9%
				7	Papain+pectase+neutral protease (3:1:1)	37.6	30.1%
8	Papain+cellulase (2:1)	39.4	31.5%
				9	Pectase+papain+cellulase (1:1:1)	41.4	33.1%
10	Pectase+papain+cellulase (2:2:1)	71.75	57.4%

Screening test result according to table 7 enzyme class shows, group number 10 pectases+papain+cellulase (2:2:1) is the highest in the yield extracting Herba Artemisiae Scopariae, compare with other enzymes that there were significant differences, therefore compound enzyme preferred pectin enzyme+papain+cellulase (2:2:1).

3, the proportioning of enzyme or compound enzyme and Semen Arecae is: enzyme or compound enzyme 20g, Semen Arecae 125g; Semen Arecae adding 8 times amount water soaking 30 minutes, add enzyme or compound enzyme, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filter, it is the extractum of 1.35～1.40 that filtrate is concentrated into 50 DEG C of survey relative densities;

Semen Arecae is extracted according to said ratio and extracting method with 10 kinds of enzymes in table 8 or compound enzyme, the yield obvious difference extracted between different enzymes, wherein notable with pectase+papain+cellulase 2:2:1 compound enzyme effect coordinated, comparing with other kinds of enzyme, there were significant differences in yield raising. Refer to table 8.

The screening test result (Semen Arecae) of table 8 enzyme class

Group number	Enzyme class	Semen Arecae yield g	Semen Arecae yield %
				1	Cellulase	19.5	15.6%
2	Pectase	25.9	20.7%
				3	Papain	29.3	23.4%
4	Neutral protease	29.4	23.5%
				5	Pectase+papain (2:2)	37.63	30.1%
6	Pectase+cellulase (2:1)	36.9	29.5%
				7	Papain+pectase+neutral protease (3:1:1)	39	31.2%
8	Papain+cellulase (2:1)	40.9	32.7%
				9	Pectase+papain+cellulase (1:1:1)	42.6	34.1%
10	Pectase+papain+cellulase (2:2:1)	71.6	57.3%

Screening test result according to table 8 enzyme class shows, group number 10 pectases+papain+cellulase (2:2:1) is the highest in the yield extracting Semen Arecae, compare with other enzymes that there were significant differences, therefore compound enzyme preferred pectin enzyme+papain+cellulase (2:2:1).

4, the ratio screening of papain, pectase and neutral protease. In Table 9

Table 9 pectase, papain, cellulase ratio screening test result

Ratio screening test result according to table 9 papain, pectase and neutral protease shows, the yield that the ratio of group number 5 pectases+papain+cellulase (2:2:1) obtains when extracting Herba Lysimachiae, Herba Artemisiae Scopariae and Semen Arecae respectively for the highest, compares with other ratios that there were significant differences. Therefore pectase+papain+preferred 2:2:1 of cellulase ratio.

5, the consumption of compound enzyme (pectase, papain, cellulase) screens.In Table 10-12

Table 10 compound enzyme is for extracting the consumption screening test result of Herba Lysimachiae

Group number	Herba Lysimachiae consumption	Compound enzyme consumption	Herba Lysimachiae yield %
				1	125g	10g	33.5%
2	125g	20g	56.3%
				3	125g	30g	35.8%

Table 11 compound enzyme is for extracting the consumption screening test result of Herba Artemisiae Scopariae

Group number	Herba Artemisiae Scopariae consumption	Compound enzyme consumption	Herba Artemisiae Scopariae yield %
				1	125g	10g	34.5%
2	125g	20g	57.4%
				3	125g	30g	35.3%

Table 12 compound enzyme is for extracting the consumption screening test result of Semen Arecae

Group number	Semen Arecae consumption	Compound enzyme consumption	Semen Arecae yield %
				1	125g	10g	34.7%
2	125g	20g	57.3%
				3	125g	30g	36.4%

Drawing according to table 10-12 result of the test, compound enzyme consumption when being used for extracting Herba Lysimachiae, Herba Artemisiae Scopariae and Semen Arecae is the highest in the 20g yield extracted respectively.

Following embodiment all can realize the effect of above-mentioned experimental example.

Detailed description of the invention

Embodiment 1

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 100g dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns (in preferred micronizing grain size of micropowder 3-6 microns of 90-95%), the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adds the water soaking 30 minutes of 8 times amount, the compound enzyme of addition 20g, and described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate, medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet, every tablet weight 0.62g.Daily secondary, each 3.

Embodiment 2

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 100g dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns (in preferred micronizing grain size of micropowder 3-6 microns of 90-95%), the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adds the water soaking 30 minutes of 8 times amount, the compound enzyme of addition 20g, and described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate, medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet, every tablet weight 0.62g. Daily secondary, each 3.

Embodiment 3

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 100g dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns (in preferred micronizing grain size of micropowder 3-6 microns of 90-95%), the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30,The Herba Artemisiae Scopariae of remaining 1/2 amount adds the water soaking 30 minutes of 8 times amount, the compound enzyme of addition 20g, and described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate; Medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30; Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40; By the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet, every tablet weight 0.62g. Daily secondary, each 3.

Embodiment 4

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 60g dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 5 microns (in preferred micronizing grain size of micropowder 2-5 microns of 90-95%), the Herba Lysimachiae of the 1/2 amount water soaking 40 minutes of 6 times amount under remainder, add 12g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 50 DEG C of enzymolysis of 20 minutes, then decoct, first time decocts 4 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2.5 hours of 4 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 75 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 75 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adds the water soaking 20 minutes of 10 times amount, the compound enzyme of addition 28g, and described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 30 DEG C of enzymolysis of 40 minutes, then decocting, first time decocts 1.5 hours, filters to get filtrate, medicinal residues with the soak by water 1 hour of 8 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 5 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 6 times amount water soaking 40 minutes, add the compound enzyme of 12g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 50 DEG C of enzymolysis of 20 minutes, then decoct twice, each 1.5 hours, merge twice decocting liquid, filtering, filtrate is concentrated into 35 DEG C and surveys the extractum C that relative density is 1.35～1.40,By the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 50 orders, superfine powder is placed on CO₂Soaking 2 hours in extraction kettle, controlling pressure in extraction kettle is 30MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 4MPa, heats to 50 DEG C, keeps 3 hours, CO₂Flow maintain 35Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas micropowders to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet, every tablet weight 0.62g, daily secondary, each 3.

Embodiment 5

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 140g dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 7 microns (in preferred micronizing grain size of micropowder 4-7 microns of 90-95%), the Herba Lysimachiae of the 1/2 amount water soaking 20 minutes of 10 times amount under remainder, add 28g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 30 DEG C of enzymolysis of 40 minutes, then decoct, first time decocts 2 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 1.5 hours of 8 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 85 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 65 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adds the water soaking 40 minutes of 6 times amount, the compound enzyme of addition 12g, and described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 50 DEG C of enzymolysis of 20 minutes, then decocting, first time decocts 2.5 hours, filters to get filtrate, medicinal residues with the soak by water 1 hour of 8 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 5 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 10 times amount water soaking 20 minutes, add the compound enzyme of 28g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 30 DEG C of enzymolysis of 40 minutes, then decoct twice, each 0.5 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 70 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 30 orders, superfine powder is placed on CO₂Soaking 4 hours in extraction kettle, controlling pressure in extraction kettle is 20MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 8MPa, heats to 30 DEG C, keeps 7 hours, CO₂Flow maintain 25Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas micropowders to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet, every tablet weight 0.62g, daily secondary, each 3.

Embodiment 6

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns (in preferred micronizing grain size of micropowder 3-6 microns of 90-95%), the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adds the water soaking 30 minutes of 8 times amount, the compound enzyme of addition 20g, and described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate, medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet, every tablet weight 0.62g, daily secondary, each 3.

Claims

1. a cholagogic and lithagogue tablet, it is characterised in that this cholagogic and lithagogue tablet is made up of following crude drug and adjuvant:

Carboxymethyl starch sodium 2.5-7.5 weight portion cross-linking sodium carboxymethyl cellulose 2.5-7.5 weight portion.

2. cholagogic and lithagogue tablet as claimed in claim 1, it is characterised in that this cholagogic and lithagogue tablet is made up of following crude drug and adjuvant:

Carboxymethyl starch sodium 4-6 weight portion cross-linking sodium carboxymethyl cellulose 4-6 weight portion.

3. cholagogic and lithagogue tablet as claimed in claim 1, it is characterised in that this cholagogic and lithagogue tablet is made up of following crude drug and adjuvant:

Or

4. the cholagogic and lithagogue tablet as described in one of claim 1-3, it is characterised in that this cholagogic and lithagogue tablet is prepared from by following methods:

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders;In micronizing, the grain size of micropowder of more than 85% is less than 8 microns, the Herba Lysimachiae of 1/2 amount water soaking 15-45 minute of 4-12 times amount under remainder, add 10-30 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, medicinal residues are again with soak by water 1-3 hour of 3-9 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount is added water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, medicinal residues with soak by water 1-2 hour of 3-9 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 20-60 order, superfine powder is placed on CO₂Soaking 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO₂Flow maintain 20-40Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas micropowders to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

5. cholagogic and lithagogue tablet as claimed in claim 4, it is characterised in that this cholagogic and lithagogue tablet is prepared from by following methods: the Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 50-150 weight portion dry ice as coolant, in micronizing, the grain size of micropowder of 85-99% is less than 6 microns, the Herba Lysimachiae of 1/2 amount water soaking 15-45 minute of 4-12 times amount under remainder, add 10-30 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, medicinal residues are again with soak by water 1-3 hour of 3-9 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30,The Herba Artemisiae Scopariae of remaining 1/2 amount is added water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate; Medicinal residues with soak by water 1-2 hour of 3-9 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30; Semen Arecae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35～1.40; By the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 20-60 order, superfine powder is placed on CO₂Soaking 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO₂Flow maintain 20-40Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas micropowders to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

6. cholagogic and lithagogue tablet as claimed in claim 5, it is characterised in that this cholagogic and lithagogue tablet is prepared from by following methods:

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 100 weight portion dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns, the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20 weight portion compound enzymes, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adding the water soaking 30 minutes of 8 times amount, adds the compound enzyme of 20 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate, medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30,Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40; By the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

7. cholagogic and lithagogue tablet as claimed in claim 1 or 2, it is characterised in that the unit of described weight portion is g, and this cholagogic and lithagogue tablet is made up of following crude drug, adjuvant and preparation method:

Preparation method is:

The Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 100g dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns, the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adds the water soaking 30 minutes of 8 times amount, the compound enzyme of addition 20g, and described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate, medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h;Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet, every tablet weight 0.62g.

8. the preparation method of the cholagogic and lithagogue tablet as described in one of claim 1-3, it is characterised in that this preparation method is: the Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders, micronizing process sprays into 50-150 weight portion dry ice as coolant, in micronizing, the grain size of micropowder of 85-99% is less than 8 microns, the Herba Lysimachiae of 1/2 amount water soaking 15-45 minute of 4-12 times amount under remainder, add 10-30 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, medicinal residues are again with soak by water 1-3 hour of 3-9 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount is added water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, medicinal residues with soak by water 1-2 hour of 3-9 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 10-30 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 20-60 order, superfine powder is placed on CO₂Soaking 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO₂Flow maintain 20-40Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas micropowders to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

9. the preparation method of cholagogic and lithagogue tablet as claimed in claim 8, it is characterised in that this preparation method is: the Herba Lysimachiae of 1/2 amount, the Herba Artemisiae Scopariae of 1/2 amount, the Radix Et Rhizoma Rhei of 1/2 amount, Radix Scutellariae and Natrii Sulfas micronizing respectively are obtained micropowders;Micronizing process sprays into 100 weight portion dry ice as coolant, in micronizing, the grain size of micropowder of 85-95% is less than 6 microns, the Herba Lysimachiae of the 1/2 amount water soaking 30 minutes of 8 times amount under remainder, add 20 weight portion compound enzymes, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, medicinal residues are again with the soak by water 2 hours of 6 times amount, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, stand, take supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Herba Artemisiae Scopariae of remaining 1/2 amount adding the water soaking 30 minutes of 8 times amount, adds the compound enzyme of 20 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decocting, first time decocts 2 hours, filters to get filtrate, medicinal residues with the soak by water 1.5 hours of 6 times amount, filter, obtain filtrate, merge twice filtrate again, filter, filtrate centrifugation, and 3000rpm is centrifuged, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Semen Arecae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 20 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filtering, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35～1.40, by the remaining Radix Et Rhizoma Rhei of 1/2 amount, the Radix Aucklandiae, Radix Curcumae, Fructus Aurantii Immaturus (parched with bran) and Cortex Magnoliae Officinalis(processed with ginger) micronizing to 40 orders, superfine powder is placed on CO₂Soaking 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa; Being easily separated in separating still by superfine powder after soaking, controlling separating pressure value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO₂Flow maintain 30Kg/h; Extract after separation is dried and obtains extract D; Extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred uniformly, add Herba Lysimachiae, Herba Artemisiae Scopariae, Radix Et Rhizoma Rhei, Radix Scutellariae and Natrii Sulfas to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring, make granule, tabletted, film coating sheet.

10. the application in the medicine that the damp and hot hypochondriac pain accumulate caused by poison, FU QI being obstructed and gallbladder-distention, cholecystitis or cholelithiasis are treated in preparation of the cholagogic and lithagogue tablet as described in one of claim 1-7.