CN105535301A

CN105535301A - Fat-reducing and weight-losing tablets and preparation method thereof

Info

Publication number: CN105535301A
Application number: CN201610045918.7A
Authority: CN
Inventors: 韩志强
Original assignee: Individual
Current assignee: Individual
Priority date: 2016-01-25
Filing date: 2016-01-25
Publication date: 2016-05-04

Abstract

The invention discloses fat-reducing and weight-losing tablets and a preparation method thereof. The fat-reducing and weight-losing tablets are prepared from radix polygoni multiflori, pseudo-ginseng, radix puerariae, semen cuscutae, fructus lycii, pine pollen, the root of red-rooted salvia, rheum officinale, rhizoma alismatis, capillary wormwood herbs, polyvinylpolypyrrolidone, sodium carboxymethyl starch and croscarmellose sodium. According to the preparation method of the fat-reducing and weight-losing tablets, pseudo-ginseng, semen cuscutae, a half amount of radix polygoni multiflori, a half amount of radix puerariae and a half amount of fructus lycii are ground in a superfine mode, a rest half amount of radix polygoni multiflori, a rest half amount of radix puerariae and the root of red-rooted salvia are extracted with a compound enzyme. The remaining bulk drugs except pine pollen are extracted in a supercritical mode, and finally mixed with pine pollen to be prepared into the tablets. The preparation method has the advantages that the improved technology is used for extracting the active ingredients, the active ingredients are safer, the content is larger, the drug dissolution speed is high, bioavailability is high, and stability is high.

Description

A kind of Jiangzhi Jianfei Tablets and preparation method thereof

Technical field

The present invention relates to a kind of pharmaceutical formulation of field of medicaments, particularly relate to a kind of Jiangzhi Jianfei Tablets and preparation method thereof.

Background technology

Jiangzhi Jianfei Tablets is that Chinese Pharmacopoeia records kind.Be prepared from by Radix Polygoni Multiflori, Radix Notoginseng, Radix Puerariae, Semen Cuscutae, Fructus Lycii, Pollen Pini, Radix Salviae Miltiorrhizae, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae, for various hyperlipidemia, cerebrovascular sclerosis, Simple Obesity, habitual constipation, bleeding hemorrhoids.

Current Jiangzhi Jianfei Tablets preparation technology continues to use Conventional processing methods, eight tastes such as except Pollen Pini, it is for subsequent use that Radix Notoginseng powder is broken into fine powder, all the other Radix Polygoni Multiflori are ground into coarse powder, alcohol reflux, reclaim ethanol and be condensed into extractum, medicinal residues decoct with water, and collecting decoction is condensed into cream, dry, be ground into fine powder, then mix with Pollen Pini, Radix Notoginseng powder, alcohol-extracted extract, make tablet.Due to common grinder be open pulverizing can there is granulation time particle diameter large, can cause heavy metal pollution, drug-eluting speed is slow, the shortcomings such as bioavailability is low.Due to mixed extraction or decoction, the active ingredient of its single crude drug can be impelled unstable, and the extraction ratio that crude drug mixing decocts active ingredient also can reduce greatly, also inevitably proposes a large amount of water-solubility impurity.The content of the amount of the effect that traditional Chinese medicine disease prevention is cured the disease and extract and wherein effective ingredient has direct relation.If extraction process is unreasonable, not science, destruction and the loss of effective ingredient certainly will be caused, thus affect quality, the curative effect of preparation.In addition, the disintegration time of existing Jiangzhi Jianfei Tablets is longer, and after long-term especially placement, have the phenomenon exceeding standards of pharmacopoeia, the long meeting of disintegration time has a strong impact on the absorption of medicine.

Along with clinically to drug quality, the improving constantly and the development of pharmaceutical technology of effect requirements, this technique can not meet current demand, be badly in need of the preparation process that a kind of extracts active ingredients is more complete, content is higher, to play the medical value of the classical prescription of Jiangzhi Jianfei Tablets better.

Summary of the invention

The object of the invention is for the deficiencies in the prior art, there is provided a kind of extracts active ingredients more completely, content is higher, drug-eluting speed is fast, bioavailability is high and the preparation technology of the Jiangzhi Jianfei Tablets of good stability, thus plays the medical value of this traditional proved recipe better.

The object of the invention is to provide a kind of lowering blood-fat and reducing weight tablet preparation.

Another object of the present invention is to the preparation method that a kind of Jiangzhi Jianfei Tablets is provided.

The present invention is achieved through the following technical solutions:

Jiangzhi Jianfei Tablets of the present invention is made up of following crude drug and adjuvant:

Jiangzhi Jianfei Tablets of the present invention is preferably as follows crude drug and adjuvant composition:

Jiangzhi Jianfei Tablets of the present invention is also preferably as follows crude drug and adjuvant composition:

The invention provides a kind of Jiangzhi Jianfei Tablets, this Jiangzhi Jianfei Tablets is prepared from by following methods:

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, in micronizing, the grain size of micropowder of more than 85 is no more than 8 microns, the Radix Polygoni Multiflori water soaking 15-45 minute of 4-12 times amount of 1/2 amount under remainder, add 25-75 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, the soak by water 1-3 hour of 3-9 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 25-75 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, the soak by water 1-2 hour of 3-9 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 12-38 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filter, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 20-60 order, superfine powder is placed on CO ₂soak 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO ₂flow maintain 20-40Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

The invention provides a kind of Jiangzhi Jianfei Tablets, this Jiangzhi Jianfei Tablets also can be prepared from by following methods:

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 10-30 weight portion dry ice is sprayed into as coolant in micronizing process, in micronizing, at least the grain size of micropowder of 85-99% is no more than 6 microns, the Radix Polygoni Multiflori water soaking 15-45 minute of 4-12 times amount of 1/2 amount under remainder, add 25-75 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, the soak by water 1-3 hour of 3-9 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 25-75 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, the soak by water 1-2 hour of 3-9 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 12-38 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filter, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 20-60 order, superfine powder is placed on CO ₂soak 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO ₂flow maintain 20-40Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

The invention provides a kind of Jiangzhi Jianfei Tablets, the preferred following methods of this Jiangzhi Jianfei Tablets is prepared from:

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 20 weight portion dry ice are sprayed into as coolant in micronizing process, in micronizing, at least the grain size of micropowder of 90-95% is no more than 6 microns, the Radix Polygoni Multiflori water soaking 30 minutes of 8 times amount of 1/2 amount under remainder, add 50 weight portion compound enzymes, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, the soak by water 2 hours of 6 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 30 minutes of 8 times amount, add the compound enzyme of 50 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 2 hours, filters to get filtrate, the soak by water 1.5 hours of 6 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 25 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filter, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 40 order, superfine powder is placed on CO ₂soak 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO ₂flow maintain 30Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

The preparation method of Jiangzhi Jianfei Tablets of the present invention is: by the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 10-30 weight portion dry ice is sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 85-99% is no more than 8 microns, the Radix Polygoni Multiflori water soaking 15-45 minute of 4-12 times amount of 1/2 amount under remainder, add 25-75 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, the soak by water 1-3 hour of 3-9 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 25-75 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, the soak by water 1-2 hour of 3-9 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 12-38 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filter, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 20-60 order, superfine powder is placed on CO ₂soak 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO ₂flow maintain 2.-40Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

The preparation method of Jiangzhi Jianfei Tablets of the present invention is preferably: by the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 20 weight portion dry ice are sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 90-95% is no more than 6 microns, the Radix Polygoni Multiflori water soaking 30 minutes of 8 times amount of 1/2 amount under remainder, add 50 weight portion compound enzymes, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, the soak by water 2 hours of 6 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 30 minutes of 8 times amount, add the compound enzyme of 50 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 2 hours, filters to get filtrate, the soak by water 1.5 hours of 6 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 25 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filter, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 40 order, superfine powder is placed on CO ₂soak 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO ₂flow maintain 30Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

Jiangzhi Jianfei Tablets of the present invention is made up of following crude drug, adjuvant and preparation method:

Described weight portion take g as unit of account;

Preparation method is:

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 20g dry ice is sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 90-95% is no more than 6 microns, the Radix Polygoni Multiflori water soaking 30 minutes of 8 times amount of 1/2 amount under remainder, add 50g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, the soak by water 2 hours of 6 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 30 minutes of 8 times amount, add the compound enzyme of 50g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 2 hours, filters to get filtrate, the soak by water 1.5 hours of 6 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 25g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filter, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 40 order, superfine powder is placed on CO ₂soak 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO ₂flow maintain 30Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet, the heavy 0.62g of every sheet.

The application of Jiangzhi Jianfei Tablets of the present invention in the medicine of preparation treatment various hyperlipidemia, cerebrovascular sclerosis, Simple Obesity, habitual constipation or bleeding hemorrhoids.

The advantage of Jiangzhi Jianfei Tablets of the present invention is, the Fructus Lycii micronizing respectively of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount, through freezing pretreatment before pulverizing, and in superfine powder, spray into dry ice as coolant, abrasive body can obtain effective cooling in very short time, makes pulverized Chinese crude drug in very short time, reach the effect of micronizing and keep high biological activity.And the grain size of micropowder of micronizing is little, because micronizing process materials temperature is lower than-18 DEG C; Chinese crude drug superfine powder after micronizing, pollution-free, the heavy metal break flour microgranules such as Chrome-free, nickel, cadmium, titanium, ferrum, copper, zinc, lead, arsenic peel off and disengage.Separately the remaining Radix Polygoni Multiflori of 1/2 amount, the Radix Puerariae of 1/2 amount and Radix Salviae Miltiorrhizae are extracted with compound enzyme respectively, make its extracts active ingredients more completely, content is higher, stability is better, the method has carried out purification to extract, curative effect there has also been with traditional technics comparing and significantly improves, and also greatly reduces production cost; All the other crude drug except Pollen Pini carry out supercritical extraction, and its effective ingredient is not destroyed, and the active ingredient of extracting medicine is more complete, and the dissolution of medicine is high, drug effect retention time is long and bioavailability is high.Technique after the present invention improves also added appropriate disintegrating agent, and tablet disintegration times made after adding disintegrating agent, at about 12 minutes, accelerates placement also complete disintegrate at about 17 minutes after 6 months.Effectively prevent disintegrate and cross the slow adverse effect that curative effect is caused.

Constantly there is the application of people's studying enzyme in Chinese medicine extraction in recent years, and achieve good effect.The present invention adopts this advanced technology, and the character feature according to crude drug effective ingredient is optimized traditional decoction technique and improves.Lot of experiments has been done in selection for enzyme class and consumption.Finally obtain the tablet that above-mentioned preparation method and this method are obtained.The method has carried out purification to extract, when decreasing a large amount of impurity, the extract (extractum) obtained improves significantly than traditional method, and effective ingredient also more former traditional handicraft stablize, curative effect being more also significantly increased with traditional handicraft, also greatly reduces production cost.

Different crude drug, the enzyme that is suitable for and consumption be not quite similar.The weak effect of enzymolysis when the consumption of enzyme is on the low side, along with the concentration of enzyme raises, increases with the contact area of substrate, and enzyme digestion reaction speed increases, but not more high better, and then can produce inhibitory action when enzyme reaches a certain concentration, enzyme is not fully utilized, and causes waste.Therefore, inventor investigates the kind of enzyme and consumption, finds that difference on effect is obvious.Wherein with the compound enzyme best results of the pectase of 2:2:1, papain and cellulase ratio combination, make the extracts active ingredients of Radix Polygoni Multiflori, Radix Puerariae and Radix Salviae Miltiorrhizae more completely, content is higher, stability is better, the method has carried out purification to extract, and curative effect there has also been with traditional technics comparing and significantly improves.

Take Chinese medicine extract as the tablet of key component, because extract component is many and complicated oneself viscosity is higher, general disintegration time is all partially long, particularly long-term place after, the trend that disintegration time continues to extend is obvious.Therefore, the present invention with the addition of tablet disintegration times made after polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose at about 12 minutes, accelerates placement also complete disintegrate at about 17 minutes after 6 months.Effectively prevent disintegrate and cross the slow adverse effect that curative effect is caused.

The present inventor by following experiment investigation different process step and parameter on the impact of Chinese medicinal tablet of the present invention.

Reiterate: following test is the illustrative test in development process of the present invention in numerous test, do not contained with limit all experiments that invention people does for the present invention, object is only partial routine and the result of setting forth Chinese medicinal tablet preparation method screening and optimizing of the present invention by those data.

Experimental example one:

1, the selection of disintegrating agent of the present invention

By the processing step (before not adding adjuvant) of the invention process 1, screen according to the disintegrating agent kind of table 1 and consumption.Result shows, polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose obviously can accelerate disintegration rate, and after particularly three coordinates with 2:1:1 ratio, disintegration time significantly shortens.Refer to table 1.

The selection result of table 1 disintegrating agent

2, compare disintegration

2.1 medicament selection

Test sample 1 (according to the preparation of the embodiment of the present invention 1 method).

Test sample 2 (according to the preparation of the embodiment of the present invention 2 method)

Test sample 3 (the present invention is according to the preparation of embodiment 3 method)

Reference substance 4 preparation method:

Above ten tastes, except Pollen Pini, it is for subsequent use that Radix Notoginseng powder is broken into fine powder, eight tastes such as all the other Radix Polygoni Multiflori are ground into coarse powder, alcohol reflux, reclaim ethanol and are condensed into extractum, medicinal residues decoct with water, collecting decoction is condensed into cream, dries, is ground into fine powder, mix with Pollen Pini, Radix Notoginseng powder, alcohol-extracted extract again, add hydroxypropyl emthylcellulose 20g, granulate, dry.Film coating sheet.The heavy 0.31g of every sheet.

2.2 disintegrations checked: adopt Rotating shaker, lift disintegration tester, get each 6 of test sample 1, test sample 2, test sample 3 and reference substance 4, observe the situation by screen cloth, percent of pass height then disintegrative is good, more suitable absorption of human body.In table 2

Table 2

Group	Accelerate disintegration (min) in placement 1 month	Accelerate to place 6-12 month disintegration (min)
			Test sample 1	12.04	16.22
Test sample 2	12.13	17.12
			Test sample 3	12.08	17.15
Reference substance 4	22.16	32.93

2.3 conclusion

Can be learnt by above-mentioned table 2, the disintegration time in 1 month is placed in the acceleration of test sample 1,2 and 3 of the present invention

Be respectively 12.04,12.13 and 12.08 minutes, accelerate to place 6-12 month disintegration time also at 16.22,17.12 and 17.15 minutes, and the disintegration time that reference substance 4 accelerates in placement 1 month is 22.16 minutes, accelerating to place 6-12 month disintegration time is 32.93 minutes, and the disintegration time of test sample 1,2 and 3 of the present invention compares with the disintegration time of reference substance 4 that there were significant differences.

3, Dissolution experiments

Carried out dissolution investigation to test sample 1 (according to the preparation of the embodiment of the present invention 1 method) of the present invention, test sample 2 (according to the preparation of the embodiment of the present invention 2 method), test sample 3 (the present invention is according to the preparation of embodiment 3 method), reference substance 4 (identical with the preparation method of experiment 2 reference substance 4), the similarity estimate adopting FDA to recommend evaluates its dissolution.The results are shown in Table 3

Table 3

Because the preparation method of test sample 1,2 and 3 of the present invention all adopts micronizing and supercritical extraction, its particle diameter is less than 6 microns, dissolution 30 minutes time is more than 90%, and 60 minutes time, dissolution is more than 87%, with dissolution when 90 minutes for more than 84%.And reference substance 4 adopts Ordinary pulverization method, its particle diameter is large, and not easily stripping, the dissolution therefore 30 minutes time is 61%, and 60 minutes time, dissolution is 50%, and 90 minutes time, dissolution is 40%.The dissolution of test sample 1,2 and 3 of the present invention compares with the dissolution of reference substance 4 that there were significant differences.

4, stability experiment

Take test sample 1 (according to the preparation of the embodiment of the present invention 1 method) of the present invention, test sample 2 (according to the preparation of the embodiment of the present invention 2 method), test sample 3 (the present invention is according to the preparation of embodiment 3 method), reference substance 4 (identical with the preparation method of experiment 2 reference substance 4) each 4g respectively, injection liquid chromatography, measured at 0,2,4,12,24 month respectively, measurement result is as follows: in table 4

Table 4

As seen from the above table, the stability of test sample 1,2 and 3 of the present invention is fine, at study on the stability after 24 months, the content of its active ingredient is substantially unchanged, and reference substance 4 is at study on the stability after 24 months, the content of its active ingredient has significant change, and illustrates that the stability of inventive test sample 1,2 and 3 is significantly better than reference substance 4.

5, drug effect compares

Add up 200 routine various hyperlipidemias, cerebrovascular sclerosis, Simple Obesity, habitual constipation and bleeding hemorrhoids patient, age is in 28-65 year, wherein 100 examples take matched group medicine (according to the preparation of experimental example 1 reference substance 4 method), another 100 routine patients take of the present invention group of medicine (according to the embodiment of the present invention 1 method preparation), instructions of taking and curative effect as follows: in table 5

Table 5

Group	Number	Day/time	Each serving consumption	Take natural law	Total effective rate
						Matched group	100 people	3 times	6 (0.31g/ sheet)	5	83％
Of the present invention group	100 people	3 times	3 (0.62g/ sheet)	5	98％

Conclusion: matched group is 83% at the total effective rate of the routine patient for the treatment of various hyperlipidemia, cerebrovascular sclerosis, Simple Obesity, habitual constipation and bleeding hemorrhoids 100, of the present invention group is 98% at the total effective rate of 100 routine patients such as treatment various hyperlipidemia, cerebrovascular sclerosis, Simple Obesity, habitual constipation and bleeding hemorrhoids etc., and the total effective rate of of the present invention group compares with matched group total effective rate that there were significant differences.

The screening experiment of experimental example two, enzyme class and consumption

1, enzyme or compound enzyme (enzyme class is in table 6) with the proportioning of Radix Polygoni Multiflori are: enzyme or compound enzyme 50g, Radix Polygoni Multiflori 300g, get the water soaking 30 minutes of Radix Polygoni Multiflori 8 times amount, add enzyme or compound enzyme, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, the soak by water 2 hours of 6 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, Radix Polygoni Multiflori is extracted according to said ratio and extracting method with kind of the enzyme of 10 in table 6 or compound enzyme, the yield obvious difference extracted between different enzyme, wherein remarkable with the compound enzyme effect of pectase+papain+cellulase 2:2:1 cooperation, compare with the enzyme of other kinds, there were significant differences in yield raising.Refer to table 6.

The screening test result (Radix Polygoni Multiflori) of table 6 enzyme class

Group number	Enzyme class	Radix Polygoni Multiflori yield g	Radix Polygoni Multiflori yield %
				1	Cellulase	52.5	17.5％
2	Pectase	63.9	21.3％
				3	Papain	72.9	24.3％
4	Neutral protease	70.2	23.4％
				5	Pectase+papain (2:2)	92.7	30.9％
6	Pectase+cellulase (2:1)	85.5	28.5％
				7	Papain+pectase+neutral protease (3:1:1)	73.5	24.5％
8	Papain+cellulase (2:1)	94.5	31.5％
				9	Pectase+papain+cellulase (1:1:1)	97.8	32.6％
10	Pectase+papain+cellulase (2:2:1)	170.4	56.8％

Screening test result according to table 6 enzyme class shows, the yield that group number 10 pectases+papain+cellulase (2:2:1) is extracting Radix Polygoni Multiflori is the highest, compare with other enzymes that there were significant differences, therefore compound enzyme preferred pectin enzyme+papain+cellulase (2:2:1).

2, the proportioning of enzyme or compound enzyme and Radix Puerariae is: enzyme or compound enzyme 50g, Radix Puerariae 300g; Radix Puerariae is added the water soaking 30 minutes of 8 times amount, add enzyme or compound enzyme, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 2 hours, filters to get filtrate; The soak by water 1.5 hours of 6 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum of 1.25-1.30;

Radix Puerariae is extracted according to said ratio and extracting method with kind of the enzyme of 10 in table 7 or compound enzyme, the yield obvious difference extracted between different enzyme, wherein remarkable with the compound enzyme effect that papain+pectase+neutral protease (3:1:1) coordinates, compare with the enzyme of other kinds, there were significant differences in yield raising.Refer to table 7.

The screening test result (Radix Puerariae) of table 7 enzyme class

Group number	Enzyme class	Radix Puerariae yield g	Radix Puerariae yield %
				1	Cellulase	50.7	16.9％
2	Pectase	64.5	21.5％
				3	Papain	72.3	24.1％
4	Neutral protease	68.7	22.9％
				5	Pectase+papain (2:2)	90.3	30.1％
6	Pectase+cellulase (2:1)	83.7	27.9％
				7	Papain+pectase+neutral protease (3:1:1)	90.3	30.1％
8	Papain+cellulase (2:1)	95.1	31.7％
				9	Pectase+papain+cellulase (1:1:1)	96.3	32.1％
10	Pectase+papain+cellulase (2:2:1)	171.3	57.1％

Screening test result according to table 7 enzyme class shows, the yield that group number 10 pectases+papain+cellulase (2:2:1) is extracting Radix Puerariae is the highest, compare with other enzymes that there were significant differences, therefore compound enzyme preferred pectin enzyme+papain+cellulase (2:2:1).

3, enzyme or compound enzyme and the proportioning that obtains Radix Salviae Miltiorrhizae are: enzyme or compound enzyme 25g, Radix Salviae Miltiorrhizae 290g; Radix Salviae Miltiorrhizae is added 8 times amount water soaking 30 minutes, add enzyme or compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filter, it is the extractum of 1.35 ~ 1.40 that filtrate is concentrated into 50 DEG C of survey relative densities;

Radix Salviae Miltiorrhizae is extracted according to said ratio and extracting method with kind of the enzyme of 10 in table 8 or compound enzyme, the yield obvious difference extracted between different enzyme, wherein remarkable with the compound enzyme effect that papain+pectase+neutral protease (3:1:1) coordinates, compare with the enzyme of other kinds, there were significant differences in yield raising.Refer to table 8.

The screening test result (Radix Salviae Miltiorrhizae) of table 8 enzyme class

Group number	Enzyme class	Radix Salviae Miltiorrhizae yield g	Radix Salviae Miltiorrhizae yield %
				1	Cellulase	45.82	15.8％
2	Pectase	60.61	20.9％
				3	Papain	67.9	23.4％
4	Neutral protease	68.2	23.5％
				5	Pectase+papain (2:2)	82.1	30.4％
6	Pectase+cellulase (2:1)	84.4	29.1％
				7	Papain+pectase+neutral protease (3:1:1)	90.5	31.2％
8	Papain+cellulase (2:1)	95.1	32.8％
				9	Pectase+papain+cellulase (1:1:1)	98.9	34.1％
10	Pectase+papain+cellulase (2:2:1)	166.8	57.5％

Screening test result according to table 8 enzyme class shows, the yield that group number 10 pectases+papain+cellulase (2:2:1) is extracting Radix Salviae Miltiorrhizae is the highest, compare with other enzymes that there were significant differences, therefore compound enzyme preferred pectin enzyme+papain+cellulase (2:2:1).

4, the ratio screening of papain, pectase and neutral protease.In table 9

The ratio screening test result of table 9 pectase, papain, cellulase

Ratio screening test result according to table 9 papain, pectase and neutral protease shows, the yield that the ratio of group number 5 pectases+papain+cellulase (2:2:1) obtains when extracting Radix Polygoni Multiflori, Radix Puerariae and Radix Salviae Miltiorrhizae is respectively the highest, and comparatively there were significant differences with other ratios.Therefore pectase+papain+preferred 2:2:1 of cellulase ratio.

5, the consumption of compound enzyme (pectase, papain, cellulase) screens.In Table 10-12

Table 10 compound enzyme is for extracting the consumption screening test result of Radix Polygoni Multiflori

Group number	Radix Polygoni Multiflori consumption	Compound enzyme consumption	Radix Polygoni Multiflori yield %
				1	300g	25g	33.8％
2	300g	50g	56.8％
				3	300g	75g	35.1％

Table 11 compound enzyme is for extracting the consumption screening test result of Radix Puerariae

Group number	Radix Puerariae consumption	Compound enzyme consumption	Radix Puerariae yield %
				1	300g	25g	34.7％
2	300g	50g	57.1％
				3	300g	75g	35.9％

Table 12 compound enzyme is for extracting the consumption screening test result of Radix Salviae Miltiorrhizae

Group number	Radix Salviae Miltiorrhizae consumption	Compound enzyme consumption	Radix Salviae Miltiorrhizae yield %
				1	290g	12g	34.5％
2	290g	25g	57.5％
				3	290g	38g	36.8％

Draw according to table 10-12 result of the test, the compound enzyme yield that consumption extracts at 50g when for extracting Radix Polygoni Multiflori is the highest, and the compound enzyme yield that consumption extracts at 50g when for extracting Radix Puerariae is the highest; The yield that compound enzyme extracts when consumption is at 25g when for extracting Radix Salviae Miltiorrhizae is the highest.

Following embodiment all can realize the effect of above-mentioned experimental example.

Detailed description of the invention

embodiment 1

Preparation method is:

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 20g dry ice is sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 90-95% is no more than 6 microns, the Radix Polygoni Multiflori water soaking 30 minutes of 8 times amount of 1/2 amount under remainder, add 50g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, the soak by water 2 hours of 6 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 30 minutes of 8 times amount, add the compound enzyme of 50g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 2 hours, filters to get filtrate, the soak by water 1.5 hours of 6 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 25g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filter, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 40 order, superfine powder is placed on CO ₂soak 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO ₂flow maintain 30Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet, the heavy 0.62g of every sheet.Daily three times, each 3.

embodiment 2

embodiment 3

embodiment 4

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 12g dry ice is sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 90-95% is no more than 5 microns, the Radix Polygoni Multiflori water soaking 20 minutes of 10 times amount of 1/2 amount under remainder, add 70g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 50 DEG C of enzymolysis of 20 minutes, then decoct, first time decocts 4 hours, filter, obtain filtrate, the soak by water 2.5 hours of 4 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 40 minutes of 6 times amount, add the compound enzyme of 30g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 30 DEG C of enzymolysis of 40 minutes, then decoct, first time decocts 1.5 hours, filters to get filtrate, the soak by water 1 hour of 8 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 5 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 10 times amount water soaking 20 minutes, add the compound enzyme of 35g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 30 DEG C of enzymolysis of 40 minutes, then decoct twice, each 0.8 hour, merge twice decocting liquid, filter, filtrate is concentrated into 70 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 30 order, superfine powder is placed on CO ₂soak 4 hours in extraction kettle, controlling pressure in extraction kettle is 22MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 8MPa, heats to 30 DEG C, keeps 7 hours, CO ₂flow maintain 25Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet, the heavy 0.62g of every sheet, daily three times, each 3.

embodiment 5

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 28g dry ice is sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 85-90%% is no more than 7 microns, the Radix Polygoni Multiflori water soaking 40 minutes of 6 times amount of 1/2 amount under remainder, add 30g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 30 DEG C of enzymolysis of 40 minutes, then decoct, first time decocts 2 hours, filter, obtain filtrate, the soak by water 1.5 hours of 8 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 75 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 75 DEG C survey relative densities be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 20 minutes of 10 times amount, add the compound enzyme of 70g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 50 DEG C of enzymes of 20 minutes 1.8 hours, filter, obtain filtrate, merge twice filtrate, filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 3 minutes, separation of supernatant, water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 6 times amount water soaking 40 minutes, add the compound enzyme of 15g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 50 DEG C of enzymolysis of 20 minutes, then decoct twice, each 1.3 hours, merge twice decocting liquid, filter, filtrate is concentrated into 35 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 50 order, superfine powder is placed on CO ₂soak 2 hours in extraction kettle, controlling pressure in extraction kettle is 28MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 4MPa, heats to 50 DEG C, keeps 3 hours, CO ₂flow maintain 35Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet, the heavy 0.62g of every sheet, daily three times, each 3.

embodiment 6

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, in micronizing, the grain size of micropowder of 85-95% is no more than 6 microns, the Radix Polygoni Multiflori water soaking 30 minutes of 8 times amount of 1/2 amount under remainder, add 50g compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, the soak by water 2 hours of 6 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 30 minutes of 8 times amount, add the compound enzyme of 50g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 2 hours, filters to get filtrate, the soak by water 1.5 hours of 6 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 25g, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filter, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 40 order, superfine powder is placed on CO ₂soak 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO ₂flow maintain 30Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet, the heavy 0.62g of every sheet.Daily three times, each 3.

Claims

1. a Jiangzhi Jianfei Tablets, is characterized in that, this Jiangzhi Jianfei Tablets is made up of following crude drug and adjuvant:

2. Jiangzhi Jianfei Tablets as claimed in claim 1, it is characterized in that, this Jiangzhi Jianfei Tablets is made up of following crude drug and adjuvant:

3. Jiangzhi Jianfei Tablets as claimed in claim 1, it is characterized in that, this Jiangzhi Jianfei Tablets is made up of following crude drug and adjuvant:

Or

4. the Jiangzhi Jianfei Tablets as described in one of claim 1-3, is characterized in that, this Jiangzhi Jianfei Tablets is prepared from by following methods:

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, in micronizing, the grain size of micropowder of more than 85% is no more than 8 microns, the Radix Polygoni Multiflori water soaking 15-45 minute of 4-12 times amount of 1/2 amount under remainder, add 25-75 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, the soak by water 1-3 hour of 3-9 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 25-75 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, the soak by water 1-2 hour of 3-9 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 12-38 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filter, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 20-60 order, superfine powder is placed on CO ₂soak 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO ₂flow maintain 20-40Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

5. Jiangzhi Jianfei Tablets as claimed in claim 4, it is characterized in that, this Jiangzhi Jianfei Tablets is prepared from by following methods: by the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 10-30 weight portion dry ice is sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 85-99% is no more than 6 microns, the Radix Polygoni Multiflori water soaking 15-45 minute of 4-12 times amount of 1/2 amount under remainder, add 25-75 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, the soak by water 1-3 hour of 3-9 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 25-75 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, the soak by water 1-2 hour of 3-9 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 12-38 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filter, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 20-60 order, superfine powder is placed on CO ₂soak 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO ₂flow maintain 20-40Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

6. Jiangzhi Jianfei Tablets as claimed in claim 5, it is characterized in that, this Jiangzhi Jianfei Tablets is prepared from by following methods:

By the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 20 weight portion dry ice are sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 90-95% is no more than 6 microns, the Radix Polygoni Multiflori water soaking 30 minutes of 8 times amount of 1/2 amount under remainder, add 50 weight portion compound enzymes, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, the soak by water 2 hours of 6 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 30 minutes of 8 times amount, add the compound enzyme of 50 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 2 hours, filters to get filtrate, the soak by water 1.5 hours of 6 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 25 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filter, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 40 order, superfine powder is placed on CO ₂soak 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO ₂flow maintain 30Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

7. Jiangzhi Jianfei Tablets as claimed in claim 1 or 2, it is characterized in that, the unit of described weight portion is g, and this Jiangzhi Jianfei Tablets is made up of following crude drug, adjuvant and preparation method:

Preparation method is:

8. the preparation method of the Jiangzhi Jianfei Tablets as described in one of claim 1-3, is characterized in that, this preparation method is: by the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 10-30 weight portion dry ice is sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 85-99% is no more than 8 microns, the Radix Polygoni Multiflori water soaking 15-45 minute of 4-12 times amount of 1/2 amount under remainder, add 25-75 weight portion compound enzyme, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1.5-4.5 hour, filter, obtain filtrate, the soak by water 1-3 hour of 3-9 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 70-90 DEG C of survey relative density, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 60-80 DEG C survey relative density be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 15-45 minute of 4-12 times amount, add the compound enzyme of 25-75 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct, first time decocts 1-3 hour, filters to get filtrate, the soak by water 1-2 hour of 3-9 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 2-6 minute, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 4-12 times amount water soaking 15-45 minute, add the compound enzyme of 12-38 weight portion, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out the 20-60 DEG C of enzymolysis of 15-45 minute, then decoct twice, each 0.5-1.5 hour, merge twice decocting liquid, filter, filtrate is concentrated into 25-75 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 20-60 order, superfine powder is placed on CO ₂soak 1.5-4.5 hour in extraction kettle, controlling pressure in extraction kettle is 20-30MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 3-9MPa, heats to 20-60 DEG C, keeps 2.5-7.5 hour, CO ₂flow maintain 2.-40Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

9. the preparation method of Jiangzhi Jianfei Tablets as claimed in claim 8, it is characterized in that, this preparation method is: by the Fructus Lycii of the Radix Polygoni Multiflori of Radix Notoginseng, Semen Cuscutae, 1/2 amount, the Radix Puerariae of 1/2 amount and 1/2 amount respectively micronizing obtain micropowders, 20 weight portion dry ice are sprayed into as coolant in micronizing process, in micronizing, the grain size of micropowder of 90-95% is no more than 6 microns, the Radix Polygoni Multiflori water soaking 30 minutes of 8 times amount of 1/2 amount under remainder, add 50 weight portion compound enzymes, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 3 hours, filter, obtain filtrate, the soak by water 2 hours of 6 times amount used again by medicinal residues, filter to get filtrate, merge twice filtrate, filter, it is 1.15-1.18 that filtrate is concentrated into 80 DEG C of survey relative densities, adding ethanol makes alcohol content reach 65%, leave standstill, get supernatant and reclaim ethanol, and be concentrated into 70 DEG C survey relative densities be the extractum A of 1.25-1.30, the Radix Puerariae of remaining 1/2 amount is added the water soaking 30 minutes of 8 times amount, add the compound enzyme of 50 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct, first time decocts 2 hours, filters to get filtrate, the soak by water 1.5 hours of 6 times amount used again by medicinal residues, filters, obtains filtrate, merge twice filtrate, and filter, filtrate centrifugalize, 3000rpm is centrifugal, centrifugal 4 minutes, separation of supernatant, and water bath method is concentrated into the extractum B of 1.25-1.30, Radix Salviae Miltiorrhizae is added 8 times amount water soaking 30 minutes, add the compound enzyme of 25 weight portions, described compound enzyme is the pectase of 2:2:1, papain and cellulase, first carry out 40 DEG C of enzymolysis of 30 minutes, then decoct twice, each 1 hour, merge twice decocting liquid, filter, filtrate is concentrated into 50 DEG C and surveys the extractum C that relative density is 1.35 ~ 1.40, by the Fructus Lycii of remaining 1/2 amount, Radix Et Rhizoma Rhei, Rhizoma Alismatis and Herba Artemisiae Scopariae micronizing to 40 order, superfine powder is placed on CO ₂soak 3 hours in extraction kettle, controlling pressure in extraction kettle is 25MPa, be separated in separating still by superfine powder after soaking, controlling disjoining pressure force value in separating still is 6MPa, heats to 40 DEG C, keeps 5 hours, CO ₂flow maintain 30Kg/h, extract after separation carries out being drying to obtain extract D, extractum A, extractum B, extractum C and supercritical extraction extract D homogenizer are stirred, add Radix Notoginseng, Semen Cuscutae, Radix Polygoni Multiflori, Radix Puerariae, Fructus Lycii micropowders and Pollen Pini again to stir, finally add polyvinylpolypyrrolidone, carboxymethyl starch sodium and cross-linking sodium carboxymethyl cellulose mixing and stirring again, make granule, tabletted, film coating sheet.

10. the application of the Jiangzhi Jianfei Tablets as described in one of claim 1-7 in the medicine of preparation treatment various hyperlipidemia, cerebrovascular sclerosis, Simple Obesity, habitual constipation or bleeding hemorrhoids.