CN108478478A - A kind of hydrogel microcapsule and its application in preparing cosmetics - Google Patents
A kind of hydrogel microcapsule and its application in preparing cosmetics Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/90—Block copolymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/91—Graft copolymers
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention discloses a kind of hydrogel microcapsules, cyst wall is the hydrogel for having anti-inflammatory, antibacterial, promoting Healing, capsule-core is cactus general flavone, lentinan and cinnamic acid active constituent composition, the active constituent of capsule-core can not only be embedded well, the influence to cactus total brass, lentinan and cinnamic acid such as light, heat is reduced, activity can be kept to never degenerate；Microcapsule structure destroys when use, capsule-core active constituent and cyst wall hydrogel are slowly mixed together to form fusion liquid, bring significant moisturizing, anti-inflammatory, antibacterial, reparation multiple skin effect to skin, hydrogel microcapsule is applied in cosmetics, it can promote the healing of small pox skin, health.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to a kind of hydrogel microcapsule and its answering in preparing cosmetics
With.
Background technology
Skin has not only acted as the effect of protection skin or a personal health has attractive appearance as the maximum organ of human body
Standard, especially face skin month after month expose in air again, ultraviolet irradiation throughout the year, pollutant, the dirt to float in air
Angstrom, bacterium etc. can all stimulate skin surface, in addition grease, sweat, the dead cell etc. of itself secretion, these factors can influence skin
Normal function performance, cause the skin diseases such as dark yellow skin, long spot, acne leads to declining in advance for skin if not nursed
Always, wherein small pox skin can also cause various skin inflammation, bacterium infection etc., and it is big portion to possess flawless skin
Divide the pursuit of people seeking beauty, therefore, other than skin cleans, daily skin care is very necessary；Accelerate damage skin
Healing, promote skin health metabolism, can also increase human appearance beauty, improve Confidence.
Cosmetics on the market are mainly the nursing for adding functional component into base-material cosmetics is made to reach certain at present
Purpose, but directly addition addition active constituent, active constituent are easy to be influenced by extraneous irresistible condition, reduce work
The effect of property ingredient, and microcapsules technology can solve the problems, such as that active constituent is destroyed above.Microcapsules technology is by trace content
Matter is wrapped in thin polymer film, can significantly protect the stability of capsule-core substance, prevents various components by broken ring, and right
Original chemical property of purpose thing is at all lossless, then makes the function of purpose thing again increasingly by outside stimulus or slow releasing function
It is secondary to be showed in outside.But the product of microcapsules technology is much used on the market, cyst material is largely guar gum
Or the high molecular polymer of some non-functionals, nursing role cannot be played to skin, or even can also accelerate the damage of skin,
Therefore, a kind of material of the material as microcapsule wall that there are multiple biological activities and generate multiple facilitation effect to skin is found
Material is cosmetics research and development urgent problem to be solved.
China Patent No. CN201580048250.5 discloses a kind of hydrogel composition, and the composition includes cross-linked polymeric
Carbomer copolymer, carbomer homopolymer, carbomer interpolymer in object etc., by the hydrogel for wound cover, emulsifiable paste
In, the good yield force of plastic emitting and mechanical force can be showed, but bioactivity is poor, cannot play multiple skin facilitation.In
State patent No. CN201310215517.8 discloses the dressing with aquagel, has fixed function to injury region, and thoroughly
Gas is preferable, although there is protective effect, bioactivity is low, cannot show multiple bioactivity and skin promotes to make
With.
Invention content
The purpose of the present invention is to provide a kind of hydrogel microcapsules, using hydrogel as cyst material, can embed well
The active constituent of capsule-core reduces the influence to cactus total brass, lentinan and cinnamic acid such as light, heat, can keep more
High activity；Microcapsule structure destroys when use, and capsule-core active constituent and cyst wall hydrogel are slowly mixed together to form fusion liquid, gives flesh
Skin brings significant moisturizing, anti-inflammatory, antibacterial, reparation multiple skin effect, applies in product for resolving poxes, promotes small pox skin
Healing, health.
To achieve the above object, the present invention provides the following technical solution：
A kind of hydrogel microcapsule, wherein core materials include the active material for having anti-inflammatory effect；Cyst material is tool
There is the active hydrogel of anti-inflammatory, antibacterial, and core materials and the weight ratio of cyst material are 0.8~2.0:1, the capsule-core material
Material and cyst material form hydrogel microcapsule by interface transfer reaction.
Further, the core materials by cactus general flavone, lentinan, cinnamic acid according to 2:1~3:1 ratio
Example composition.
The cyst material is that Quaterisation chitosan-g- polyanilines and polyethylene glycol-co- polyglycereol-sebacic acid carry out
Hydrogel made of the crosslinking of dynamic chemical key.
The hydrogel microcapsule is ball-type shape, and a diameter of 32~150 μm of microcapsules.
The hydrogel microcapsule structure is destroyed, and cyst wall hydrogel and capsule-core active matter can form mixing fusion liquid.
In addition, application of the hydrogel microcapsule in preparing cosmetics is also provided, and by quality in preparing cosmetics
The additive amount of percentage is 1.2~5.0%.
In some embodiments, the cosmetics are anti-acne mud film.
Following introduction is done to the main component of the present invention：
The hydrogel of cyst material of the present invention is the polyethylene glycol-co- poly- (glycerine-sebacic acid) with fragrant aldehyde radical functionalization
Dynamic chemical key crosslinking is carried out as crosslinking agent and Quaterisation chitosan-g- polyanilines, can obtain obtaining with self-healing, high viscous force
Hydrogel, the gel in-situ and tissue adhesion performance of the hydrogel can with the wound of quick closure arbitrary shape, and with wound wheel
Exterior feature is bonded as it and provides physical barriers and simulated skin moist environment, while having hemostatic, anti-inflammatory and antibiotic property, can be to prevent
It stops loss and hinders skin infection, the chitosan component contained, which also has, promotes healing, the electroactive and inoxidizability of polyaniline segment
Synergistic effect can generate multiple skin facilitation, be a kind of huge biomaterial of application potential.
Cactus can be used as Chinese medicine, bitter in taste, cold, enters the heart, lung, stomach three and passes through, has blood-activating and qi-promoting, clearing heat and detoxicating work(
Effect, it is resourceful, it is easy to cultivate, receives favor.Opuntia meaning flavone compound, carbohydrate, alkaloids, face
The effect of bed application finds that cactus, which has, makes local pain disappear, lump dissipation, and it is safe, there are wide indications,
Advantage significant in efficacy.Cactus Flavonoids have flavones, flavonols, flavanonol, flavanones etc., and their quilts
The cost extracted is relatively low, can be received by most people；In addition, it can increase the permeability of capillary, suppression in the short time
Inflammation swelling processed mitigates the local inflammation reactions such as swelling and exudation, has good anti-inflammatory effect.
The lentinan and M-band that mushroom contains have certain active anticancer, can inhibit the generation of tumour, contained
Tyrosinase can dissolve certain cholesterol, have certain help to reducing blood pressure, wherein lentinan have it is antibacterial and protect
Wet skin care effect can also promote wound healing and release the poisonings such as lead, arsenic, tribute, and improve glycometabolism and lipid metaboli.
Cassia bark is the dry hide of canella, also known as is Chinese cassia tree, is conventional Chinese medicine, cinnamic acid is extracted from cassia bark
A kind of aromatic aldehyde, the antibacterial action with wide spectrum, the irritation of cinnamic acid is small, has stronger inhibiting effect to bacterium and fungi,
But it is long placed in air and is easy oxidation.It is to inhibit mitogenetic spore in the defense of raising host that cinnamic acid, which mainly shows pathogen,
Son is sprouted and is formed, and conidium is caused to clear up, and is caused mycelium kenel to generate abnormal, is interfered thalli growth for a long time.
It can also inhibit the formation of cell wall, increase lipophilicity and be combined with cell membrane, change the structure and integrality of cell membrane.It is expected to
Instead of the antibacterials of antibiotic and some side effects.
Compared with prior art, the device have the advantages that it is as follows：
(1) there is the hydrogel that cyst material of the present invention uses gel in-situ and tissue adhesion performance can be appointed with quick closure
The wound for shape of anticipating, and be bonded as it with wound profile and physical barriers and simulated skin moist environment are provided, while there is hemostasis
Property, anti-inflammatory and antibiotic property, damage skin infection can be prevented, the chitosan component contained, which also has, promotes healing, polyphenyl
The electroactive and inoxidizability synergistic effect of amine segment can generate multiple skin and promote；
(2) the cactus general flavone in microcapsules core materials of the present invention can increase the permeability of capillary, short time
Interior inhibition inflammation swelling mitigates the local inflammation reactions such as swelling and exudation, has good anti-inflammatory effect；Lentinan has suppression
The skin care effect of bacterium and moisturizing can also promote wound healing and release the poisonings such as lead, arsenic, tribute, the antibacterial action with wide spectrum,
Bacteriostasis is further strengthened in conjunction with cinnamic acid, it, can be faster the characteristics of, antibacterial anti-inflammatory in conjunction with microcapsule wall material, high healing power
Promote damage skin healing；
(3) subject hydrogel microcapsules can embed the active constituent of capsule-core well using hydrogel as cyst material, drop
The influence to cactus total brass, lentinan and cinnamic acid such as low light, heat, can keep activity to never degenerate；It is micro- when use
Capsule structure destroys, and capsule-core active constituent and cyst wall hydrogel be slowly mixed together to form fusion liquid, to skin bring significant moisturizing,
Multiple skin effect that is anti-inflammatory, antibacterial, repairing, hydrogel microcapsule is applied in cosmetics, can promote being cured for small pox skin
It closes, health.
Specific implementation mode
Below in conjunction with specific embodiment, the present invention is further elaborated：
Embodiment 1
It is poly- with quaternary ammoniated shell using the polyethylene glycol-co- of fragrant aldehyde radical functionalization poly- (glycerine-sebacic acid) as crosslinking agent
The hydrogel that sugar-g- polyanilines progress dynamic chemical key is crosslinked is as cyst material, core materials cactus general flavone, mushroom
Mushroom polysaccharide, cinnamic acid are according to 2:2:1 ratio composition, and core materials and the weight ratio of cyst material are 1.4:1, it is poly- with interface
It is legal, so that cyst material is wrapped in core materials surface and forms a diameter of 80 μm of hydrogel microcapsule.And the water-setting that will be obtained
Glue microcapsules are added in anti-acne mud film, additive amount 3.1%, obtain the anti-acne mud film containing hydrogel microcapsule.
Embodiment 2
It is poly- with quaternary ammoniated shell using the polyethylene glycol-co- of fragrant aldehyde radical functionalization poly- (glycerine-sebacic acid) as crosslinking agent
The hydrogel that sugar-g- polyanilines progress dynamic chemical key is crosslinked is as cyst material, core materials cactus general flavone, mushroom
Mushroom polysaccharide, cinnamic acid are according to 2:1:1 ratio composition, and core materials and the weight ratio of cyst material are 0.8:1, it is poly- with interface
It is legal, so that cyst material is wrapped in core materials surface and forms a diameter of 32 μm of hydrogel microcapsule.And the water-setting that will be obtained
Glue microcapsules are added in anti-acne mud film, additive amount 1.2%, obtain the anti-acne mud film containing hydrogel microcapsule.
Embodiment 3
It is poly- with quaternary ammoniated shell using the polyethylene glycol-co- of fragrant aldehyde radical functionalization poly- (glycerine-sebacic acid) as crosslinking agent
The hydrogel that sugar-g- polyanilines progress dynamic chemical key is crosslinked is as cyst material, core materials cactus general flavone, mushroom
Mushroom polysaccharide, cinnamic acid are according to 2:3:1 ratio composition, and core materials and the weight ratio of cyst material are 2:1, use interfacial polymerization
Method makes cyst material be wrapped in core materials surface and forms a diameter of 150 μm of hydrogel microcapsule.And the hydrogel that will be obtained
Microcapsules are added in anti-acne mud film, additive amount 5.0%, obtain the anti-acne mud film containing hydrogel microcapsule.
Comparative example 1
Using guar gum as cyst material, core materials cactus general flavone, lentinan, cinnamic acid are according to 2:2:1
Ratio composition, and core materials and the weight ratio of cyst material are 1.4:1, with interfacial polymerization, cyst material is made to be wrapped in
Core materials surface forms a diameter of 80 μm of microcapsules.And obtained microcapsules are added in anti-acne mud film, additive amount is
3.1%, obtain the anti-acne mud film containing microcapsules.
Comparative example 2
It will be poly- with quaternary ammoniated shell using the polyethylene glycol-co- of fragrant aldehyde radical functionalization poly- (glycerine-sebacic acid) as crosslinking agent
Sugar-g- polyanilines are carried out the hydrogel that dynamic chemical key is crosslinked and are directly appended in anti-acne mud film with 3.1% additive amount,
Obtain the anti-acne mud film of aqueous gel.
Comparative example 3
It is other not change with embodiment 1 difference lies in being not added with hydrogel microcapsule.
Compliance test result
Protective effect is verified：
The hydrogel microcapsule that Examples 1 to 3 is obtained exposes in air, after irradiating 8h under light illumination, with respective original
Additive amount is compared, detection obtain cactus general flavone in microcapsules, lentinan, cinnamic acid content be respectively 96.78%,
98.72% and 95.12%, illustrate that the micro-capsule package technology can be effectively realized active constituent and extraneous oxygen, dirt
Angstrom equal isolation, reduces influence of the extraneous factors such as light to active constituent, has reached protective effect.
Bacteriostasis efficacy is verified：
Laboratory sample：The anti-acne mud film that Examples 1 to 3 obtains, the anti-acne mud film that comparative example 1~3 obtains are commercially available to declare have
There are the product (control group) of acne-removing, 7 groups of propionibacterium acnes bacterial strain (isolated at patients with acne skin lesion).
Obtained strain is inoculated with, and bacteriostatic test, logging such as the following table 1 are carried out using corresponding product.
Table 1
By the bacteriostatic test of table 1 it is found that Examples 1 to 3 is added to according to the hydrogel and active constituent of preferred proportion
In anti-acne mud film, there is excellent fungistatic effect；The cyst material of microcapsules is guar gum in comparative example 1, although also having one
Fixed fungistatic effect, but its fungistatic effect is not so good as embodiment；Only it is added to hydrogel in comparative example 2, but active substance,
Its fungistatic effect is not added with hydrogel microcapsule in comparative example 3, shows worse fungistatic effect also without the notable of embodiment,
In synthesis, hydrogel microcapsule of the invention has good fungistatic effect, has to small pox skin effective.
Anti-inflammatory efficacy is verified
Main material：Mouse macrophage RAW264.7 is (thin from Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
Born of the same parents resource center), embodiment 1, comparative example 1~3, mouse prostate element E2(PGE2) ELISA detection kit, mouse tumor be bad
Necrosis factor-α (TNF-α) ELISA detection kit, lipopolysaccharides (LPS).
Method：(1) influence with mtt assay detection trial target to RAW264.7 cell growths, adjustment RAW264.7 cells are close
It spends to 5x104/ mL is inoculated in 96 porocyte culture plates, per 1000 μ L of hole, is placed in 37 DEG C, 5%CO2It is cultivated in cell incubator
24h.The culture medium in cell plates is sucked out after culture, being separately added into 200 μ L of a concentration of 500 μ g/mL biologies in processing group contains
Isometric serum free medium is added in embodiment 1, comparative example 1~3, blank control group, continues to cultivate for 24 hours, every group 3 multiple
Hole.After for 24 hours, the MTT solution of every group of 20 μ L of addition continues after cultivating 4h, takes out 96 orifice plates, liquid in hole is sucked out, 150 μ L are added
DMSO, shake 5min after in 490nm at measurement absorbance (A) value, calculate the survival rate of cell.Survival rate=medicine group is average
A values/blank control group average A-value.
(2) PGE is discharged to lipopolysaccharides (LPS) stimulation RAW264.7 cells2Influence, respectively control group (serum-free train
Support base), 1 group of embodiment (1 product of embodiment of 100 μ g/mL and the LPS of 1 μ g/mL), the comparative example group (comparative example of 100 μ g/mL
The LPS of product and 1 μ g/mL), cell culture and method and (1) together, cell supernatant are collected after LPS stimulates 18h, according to
ELISA kit specification requires to carry out PGE2Detection calculates inhibiting rate, is denoted as inhibiting rate 1.
(3) influence of TNF-a, respectively control group (serum free medium) are discharged to LPS stimulation RAW264.7 cells, it is real
Apply 1 group of example (1 product of embodiment of 100 μ g/mL and the LPS of 1 μ g/mL), the comparative example group (comparative example 1~3 and 1 μ of 100 μ g/mL
The LPS of g/mL), LPS collects cell conditioned medium after stimulating 18h, and TNF-a detections are carried out by the operation requirement of ELISA kit specification,
Inhibiting rate is calculated, inhibiting rate 2 is denoted as.
As a result it is recorded in table 2.
Table 2
By the data analysis of table 2 it is found that the present invention cyst material hydrogel have anti-inflammatory effect, with capsule-core activity at
Divide effect altogether, significant anti-inflammatory efficacy can also be played by being added in cosmetics.
The effect of in order to further verify product of the present invention, the present invention have also done following normal individual trial evaluation test：
Test products are the anti-acne mud film for the aqueous gel microcapsules that embodiment 1 is prepared, and it is small pox flesh to try out object
30 people of skin volunteer tries out the time as 2 weeks, after test period, evaluation is made to product using the method for sensory evaluation,
Result on trial is：94% volunteer thinks that the product of the present invention can increase the wettability of skin, can remarkably promote inflammation skin
Healing, keeps skin more healthy.
Therefore above example only shows several embodiments of the present invention, the description thereof is more specific and detailed, but can not be
And it is interpreted as the limitation range to patent of the present invention.It should be noted that：It is any to be engaged in professional and technical personnel, all have the ability
Using the technology contents having revealed that, some are made to it and changes or modifies, becomes the equivalent embodiment of equivalent variations.According to this hair
Bright technical spirit carries out simple modification, equivalent change and modification to the present invention, belongs in the range of technical solution of the present invention.
Claims (8)
1. a kind of hydrogel microcapsule, which is characterized in that core materials include the active material for having anti-inflammatory effect；Cyst material
For with the active hydrogel of anti-inflammatory, antibacterial, and core materials and the weight ratio of cyst material are 0.8~2.0:1, the capsule
Core material and cyst material form hydrogel microcapsule by interface transfer reaction.
2. hydrogel microcapsule according to claim 1, and it is characterized in that, the core materials are always yellow by cactus
Ketone, lentinan, cinnamic acid are according to 2:1~3:1 ratio composition.
3. hydrogel microcapsule according to claim 1, which is characterized in that the cyst material is poly- for quaternary ammoniated shell
Sugar-g- polyanilines and polyethylene glycol-co- polyglycereol-sebacic acid carry out hydrogel made of dynamic chemical key crosslinking.
4. hydrogel microcapsule according to claim 1, which is characterized in that the hydrogel microcapsule is ball-type shape,
And a diameter of 32~150 μm of microcapsules.
5. hydrogel microcapsule according to claim 1, which is characterized in that the hydrogel microcapsule structure is destroyed,
Cyst wall hydrogel and capsule-core active matter can form mixing fusion liquid.
6. according to a kind of application of the hydrogel microcapsule of Claims 1 to 5 any one of them in preparing cosmetics.
7. application according to claim 6, which is characterized in that hydrogel microcapsule in cosmetics by weight percent
Additive amount is 1.2~5.0%.
8. application according to claim 6, which is characterized in that the cosmetics are anti-acne mud film.
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| CN201810198478.8A CN108478478A (en) | 2018-03-09 | 2018-03-09 | A kind of hydrogel microcapsule and its application in preparing cosmetics |
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| CN201810198478.8A CN108478478A (en) | 2018-03-09 | 2018-03-09 | A kind of hydrogel microcapsule and its application in preparing cosmetics |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103766339A (en) * | 2013-11-13 | 2014-05-07 | 深圳松乐生物科技有限公司 | Composition containing trans-cinnamaldehyde |
| CN104523508A (en) * | 2014-12-16 | 2015-04-22 | 重庆小丸科贸有限公司 | Hydrogel microcapsule with oil-control and acne treatment effects |
-
2018
- 2018-03-09 CN CN201810198478.8A patent/CN108478478A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103766339A (en) * | 2013-11-13 | 2014-05-07 | 深圳松乐生物科技有限公司 | Composition containing trans-cinnamaldehyde |
| CN104523508A (en) * | 2014-12-16 | 2015-04-22 | 重庆小丸科贸有限公司 | Hydrogel microcapsule with oil-control and acne treatment effects |
Non-Patent Citations (3)
| Title |
|---|
| 中国浙江网上技术市场: "西安交通大学科技成果推介（十九）", 《HTTPS://WWW.SOHU.COM/A/208235676_423286》 * |
| 王建新: "《化妆品植物原料大全》", 30 June 2012, 中国纺织出版社 * |
| 邓舜扬: "《化学配方与工艺手册》", 31 January 2003, 上海科学技术文献出版社 * |
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