CN109260059A - A kind of essential oil composition with anti-acne and skin repair and application - Google Patents

A kind of essential oil composition with anti-acne and skin repair and application Download PDF

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CN109260059A
CN109260059A CN201811360633.8A CN201811360633A CN109260059A CN 109260059 A CN109260059 A CN 109260059A CN 201811360633 A CN201811360633 A CN 201811360633A CN 109260059 A CN109260059 A CN 109260059A
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essential oil
acne
oil
skin repair
skin
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CN109260059B (en
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龚盛昭
朱永闯
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GUANGZHOU HOTO TRADE Co.,Ltd.
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Guangdong Industry Technical College
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    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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    • A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
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Abstract

The present invention discloses a kind of essential oil composition with anti-acne and skin repair and application, belongs to cosmetic field.The essential oil composition by being made following weight percentage components: tea tree ethereal oil 0.05~15.0%；Essential Oil From Pine Needles 0.1~6.0%；Myrrh essential oil 0.1~7.0%；Angelica essential oil 0.05~6.0%；Peony essential oil 0.1~6.0%；Styrax essential oil 0.1~6.0%；Base oil is surplus.Essential oil composition of the invention is with the traditional Chinese medical science prescription theory of monarch for guidance, it is obtained through a large amount of experimental study of inventor, selected tea tree ethereal oil, Essential Oil From Pine Needles, myrrh essential oil, angelica essential oil, peony essential oil, styrax essential oil carry out the best prescription that Experiment of Compatibility obtains according to specific ratio.Various components are arranged in pairs or groups according to special ratios, reach synergistic, carry out complex treatment to acne skin from dredging skin pore, antibacterial, promoting blood circulation, myogenic, whitening etc..

Description

A kind of essential oil composition with anti-acne and skin repair and application
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of essential oil composition with anti-acne and skin repair and Using.
Background technique
With the continuous improvement of people's lives level and quality of the life, beauty and skin care of the consumer to daily life indispensability The requirement of product is higher and higher, increasingly the influence of emphasis " back to nature " tendency plant skin care theory.
Whelk, acne, dark sore are medically referred to as acne, are a kind of common sebaceous glands chronic diseases, and the origin cause of formation is When puberty, intracorporal hormone can stimulate hair growth, and smegma is vigorous, and clogging of pores is caused to form an acne Core --- micro mist thorn.Micro mist thorn be it is invisible, micro mist thorn is skin surface needs 7 to 9 months from is forming to growing Growth period.Micro mist thorn blocking pore induces inflammation, is that papule, useless fellow, tubercle and tumour originate root.Traditional treatment is only clear Except the acne on surface, and micro mist thorn stops growing for a period of time, then forms the situation of acne recurrent exerbation.In addition, Cuo Sore, which forms dark acne print, also can cause mental handicape to people.So scientific anti-acne should be from dredging skin pore, antibacterial, work Blood, myogenic, whitening etc. comprehensive treatment.
Essential oil molecular weight is small, and readily permeable skin is absorbed, and enters deep skin, has extraordinary treatment for acne Effect, the gradually deep favor by people of essential oil anti-acne skin care item.
CN2018100726897 discloses a kind of acne removal essential oil containing tea tree ethereal oil, wherein containing tea tree ethereal oil, smoking clothing Careless essential oil, alkannin and other cosmetic compositions, the acne removal essential oil use Pure natural plant essential oil, are small molecule objects using essential oil Matter, good penetrability, absorption of human body is fast, and alkannin is made to reach cell deep layer rapidly under the guidance and effect of essential oil, finds acne source, Inhibit its activity, to make acne flesh generative capacity rapid decrease, acne flesh there has been improvement in a short time, it is safe and non-stimulating, for a long time Using effect is more preferably；On the other hand it reconciles base oil by a certain percentage, plays synergistic effect, further enhance clear acne effect.
CN2017107616130 discloses a kind of anti-acne repair latex containing essential oil, wherein containing Lavender, rose Essential oil, tea tree ethereal oil, chamomile essential oil, cypress essential oil, Bergamot, lily essential oil and other cosmetic compositions.The invention Lotion natural component it is high, easily absorb, and anti-acne effect is good.
CN201410781176.5 discloses the tree peony compound essential oil and preparation method thereof that a kind of net skin removes acne, wherein containing Fresh peony flower essential oil, Salvia japonica essential oil, eucalyptus quintessence oil, green tea essential oil, flores aurantii essential oil, Patchouli essential oil, yulan flower essential oil, Du Loose essential oil, peony seed oil, the essential oil can go deep into hair follicle depths, eliminate skin oil and fat and dirt, kill bacillus acnes and its His acne correlation flora reinforces skin repair, and net skin is significant in efficacy and safe and non-stimulating except acne, has no toxic side effect, and is suitable for long-term It uses.
Summary of the invention
In order to overcome the disadvantages and deficiencies of the prior art, the primary purpose of the present invention is that providing a kind of with anti-acne and skin Skin repairs the essential oil composition of effect.The present invention provides a kind of with dredging skin using the theory of traditional Chinese medical science of monarch as foundation Pore, antibacterial, promoting blood circulation, myogenic, white-skinned face function essential oil composition.
Another object of the present invention is to provide a kind of above-mentioned essential oil compositions with anti-acne and skin repair Using.
The purpose of the invention is achieved by the following technical solution:
A kind of essential oil composition with anti-acne and skin repair, by being made following weight percentage components: tea Set essential oil 0.05~15.0%；Essential Oil From Pine Needles 0.1~6.0%；Myrrh essential oil 0.1~7.0%；Angelica essential oil 0.05~6.0%； Peony essential oil 0.1~6.0%；Styrax essential oil 0.1~6.0%；Base oil is surplus.
Preferably, the essential oil composition with anti-acne and skin repair, by the group of following weight percent Divide and be made: tea tree ethereal oil 1.0~10.0%；Essential Oil From Pine Needles 0.5~5.0%；Myrrh essential oil 0.2~5.0%；Angelica essential oil 0.5 ~5.0%；Peony essential oil 0.5~5.0%；Styrax essential oil 0.5~4.0%；Base oil is surplus.
It is further preferred that the essential oil composition with anti-acne and skin repair, by following weight percent The component of ratio is made: tea tree ethereal oil 4.5~6.0%；Essential Oil From Pine Needles 1.0~2.0%；Myrrh essential oil 0.8~1.6%；Tanquedate Oil 1.0~1.7%；Peony essential oil 1.0~2.0%；Styrax essential oil 1.0~1.5%；Base oil is surplus.
Preferably, the essential oil composition with anti-acne and skin repair, by the group of following weight percent Divide and be made: tea tree ethereal oil 5.0%；Essential Oil From Pine Needles 2.0%；Myrrh essential oil 0.8%；Angelica essential oil 1.2%；Peony essential oil 2.0%； Styrax essential oil 1.0%；Base oil is surplus.
Preferably, the essential oil composition with anti-acne and skin repair, by the group of following weight percent Divide and be made: tea tree ethereal oil 4.5%；Essential Oil From Pine Needles 1.5%；Myrrh essential oil 1.2%；Angelica essential oil 1.5%；Peony essential oil 1.8%； Styrax essential oil 1.5%；Base oil is surplus.
Preferably, the essential oil composition with anti-acne and skin repair, by the group of following weight percent Divide and be made: tea tree ethereal oil 6.0%；Essential Oil From Pine Needles 1.0%；Myrrh essential oil 1.5%；Angelica essential oil 1.0%；Peony essential oil 1.5%； Styrax essential oil 1.0%；Base oil is surplus.
Preferably, the essential oil composition with anti-acne and skin repair, by the group of following weight percent Divide and be made: tea tree ethereal oil 5.5%；Essential Oil From Pine Needles 1.2%；Myrrh essential oil 1.6%；Angelica essential oil 1.7%；Peony essential oil 1.0%； Styrax essential oil 1.0%；Base oil is surplus.
Above-described base oil is one of grape seed oil, wheat-germ oil, olive oil, jojoba oil or a variety of Mixture.
A further object of the present invention is to provide a kind of above-mentioned essential oil compositions with anti-acne and skin repair to exist Application in cosmetics.
In order to reach this purpose of the invention, this invention takes following technical solutions:
It is a kind of to have effects that the essential oil composition of anti-acne and skin repair in the application prepared in cosmetics, the cosmetics In contain the essential oil composition with anti-acne and skin repair, the additive amount in cosmetics is based on mass fraction For 0.1~25% (preferably 8~10%).
The present invention also provides a kind of cosmetics with anti-acne and skin repair, the cosmetics contain it is above-mentioned have dispel The essential oil composition of acne and skin repair effect.
Preferably, it is that having for 0.1~25% (preferably 8~10%) is dispelled which contains above-mentioned based on mass fraction The essential oil composition of acne and skin repair effect.
The cosmetics are as follows: aqua, cream kind, facial mask, spray-like, essence class, essential oil class, soaps, washes shield at type of latex type Class.
Specifically, the present invention provides a kind of anti-acne reparation essence cream, the component including following mass fraction meter:
Ingredient Mass fraction/%
Deionized water Surplus
Butanediol 2.00
EDETATE SODIUM 0.02
Allantoin 0.10
Hydrolecithin 1.00
Acritamer 940 0.10
Acrylic acid (ester) class/C10-30 alkylol acrylamide acid esters cross-linked polymer 0.40
1,2- hexylene glycol 0.80
Parahydroxyacet-ophenone 0.40
Parleam 4.00
Dimethyl silicone polymer 2.00
Polyglycereol-3-methyl distearate 1.50
Stearine 0.50
Aminomethyl propanol 0.30
Phenoxyethanol 0.20
Essential oil composition of the present invention 10.00
Specifically, the present invention provides a kind of anti-acne reparation facial mask, the component including following mass fraction meter:
Ingredient Mass fraction/%
Glycerol 5.00
Sodium Hyaluronate 0.10
Allantoin 0.20
Panthenol 1.00
Deionized water Surplus
941 1% aqueous solution of card wave 15.00
1,3- propylene glycol 8.00
Methyl hydroxybenzoate 0.12
Nipasol 0.02
Aminomethyl propanol 0.08
Essential oil composition of the present invention 8.00
Specifically, the present invention provides a kind of anti-acne reparation essential oil, the component including following mass fraction meter:
Ingredient names Mass fraction/%
Saualane 42
Caprylic/capric triglyceride 30
Isononyl isononanoate 14
Jojoba oil 4
Essential oil composition of the present invention 10
Foundation of the invention:
A kind of essential oil composition with anti-acne and skin repair of the invention is the traditional Chinese medical science prescription with monarch Theory is guidance, is obtained through a large amount of experimental study of inventor, selected tea tree ethereal oil, Essential Oil From Pine Needles, myrrh essential oil, Radix Angelicae Sinensis Essential oil, peony essential oil, styrax essential oil carry out the best prescription that Experiment of Compatibility obtains according to specific ratio.Essential oil of the invention Tea tree ethereal oil is monarch drug in a prescription in composition, has effects that strong bactericidal anti-inflammatory, oil-control；Essential Oil From Pine Needles and myrrh essential oil are minister jointly Medicine, Essential Oil From Pine Needles have good bactericidal antiphlogistic effect, and have good dredging pore, promoting blood circulation, promote wound healing effect, myrrh Essential oil has effects that good bactericidal antiphlogistic effect and blood activating and promoting tissue regeneration；Angelica essential oil and peony essential oil are adjutant jointly, are all had strong Green blood, promoting blood circulation effect and potent whitening function are imitated, so that toxin, desalination acne print be discharged；Styrax essential oil is to make medicine, essence of resting in peace Oil is highly useful to cracking, dry skin, and skin can be made to restore elasticity, have good efficacy to skin ulcer, wound, while to skin Skin is rubescent, itch with stimulation phenomena such as it is also effective in cure.
The present invention has the following advantages and effects with respect to the prior art:
Various components are arranged in pairs or groups according to special ratios in essential oil composition of the invention, reach synergistic, from dredging Skin pore, antibacterial, promoting blood circulation, myogenic, whitening etc. carry out complex treatment to acne skin.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
The test method of specific experiment condition is not specified in the following example, usually according to conventional laboratory conditions or according to system Make experiment condition proposed by factory.
A kind of essential oil composition (I) with anti-acne and skin repair of embodiment 1
A kind of essential oil composition with anti-acne and skin repair, by being made following weight percentage components: tea Set essential oil 5.0%；Essential Oil From Pine Needles 2.0%；Myrrh essential oil 0.8%；Angelica essential oil 1.2%；Peony essential oil 2.0%；It rests in peace essence Oil 1.0%；Grape seed oil is surplus.
A kind of essential oil composition (II) with anti-acne and skin repair of embodiment 2
A kind of essential oil composition with anti-acne and skin repair, by being made following weight percentage components: tea Set essential oil 4.5%；Essential Oil From Pine Needles 1.5%；Myrrh essential oil 1.2%；Angelica essential oil 1.5%；Peony essential oil 1.8%；It rests in peace essence Oil 1.5%；Jojoba oil is surplus.
A kind of essential oil composition (III) with anti-acne and skin repair of embodiment 3
A kind of essential oil composition with anti-acne and skin repair, by being made following weight percentage components: tea Set essential oil 6.0%；Essential Oil From Pine Needles 1.0%；Myrrh essential oil 1.5%；Angelica essential oil 1.0%；Peony essential oil 1.5%；It rests in peace essence Oil 1.0%；Olive oil is surplus.
A kind of essential oil composition (IV) with anti-acne and skin repair of embodiment 4
A kind of essential oil composition with anti-acne and skin repair, by being made following weight percentage components: tea Set essential oil 5.5%；Essential Oil From Pine Needles 1.2%；Myrrh essential oil 1.6%；Angelica essential oil 1.7%；Peony essential oil 1.0%；It rests in peace essence Oil 1.0%；Wheat-germ oil is surplus.
The composition of comparative example 1~7 single essential oil and base oil
Specific combination is shown in Table 1.
Table 1
1 inhibition zone test of test example
Test method is Odontothrips loti (being also cylinder-plate method), and the method is domestic and international measurement titer of antibodies universal method, It is also the method for multinational States Pharmacopoeia specifications.It is tested by inhibition zone, judges sample to be tested to propionibacterium acnes The inhibiting effect of (Propionibacterium acnes) ATCC 11827.
Test sample: product prepared by embodiment 1 and comparative example 1~7 use olive oil to be diluted to 10 times after as to test sample.
With sterile working, it will be poured into the sterile petri dish of diameter 9cm by the culture medium of high-temperature sterilization, make each culture Ware has a culture medium of 15~20mL, and after cooling, 0.2mL propionibacterium acnes bacteria suspension is added, with spreading rod by media surface Oxford cup uniformly, is vertically put corresponding media surface with tweezers, gently pressurizeed, it is made to contact no sky with culture medium by coating Gap, each plate can put 3 tubules, the various to test sample of 0.1mL are added dropwise into each tubule respectively, and mark, do not make it It is excessive.Propionibacterium acnes: setting 37 DEG C of incubator Anaerobic culturels after 2~5 days, observes result.
In culture, one side test organisms starts to grow, and on the other hand spreads around to test sample using Oxford cup as origin, The border circular areas that bacterium colony cannot be grown is formed, is " inhibition zone ".Inhibition zone is bigger, and anti-acne effect is better.
Drug sensitive experiment as a result, by antibacterial circle diameter size determine susceptibility height, judgment criteria refer to the following table 2.
2 drug sensitivity assay criterion of table
Antibacterial circle diameter (millimeter) Susceptibility
20 or more It is extremely quick
15~20 Gao Min
10~14 In it is quick
10 or less Muting sensitive
0 It is unwise
Test result, as shown in table 3.
3 inhibition zone test test result of table
The result shows that the Examples 1 to 4 in the present invention inhibits propionibacterium acnes effect highly significant, than folk prescription essence The effect of oil is good, illustrates that essential oil compounding has synergistic function to propionibacterium acnes inhibition.
The experiment of 2 whitening anti-aging in-vitro evaluation of test example
1, the preparation of sample
Composition prepared by the essential oil composition and comparative example 1~7 prepared using embodiment 1 is sample.Sample 1g is dissolved in In 99g dimethyl sulfoxide, it is made into the sample solution that mass fraction is 1%, carries out test below.
2, inhibit the test of tyrosinase vigor effect assessment
It is 0.1% by the accurate pipette samples solution of table 4, the phosphate buffer solution (PBS) that pH value is 6.8 and mass fraction DOPA solution, be sufficiently mixed, after 30 DEG C of incubation 5min, the tyrosinase solution that activity is 110U/mL be added, then at 30 DEG C Lower incubation 10min, is transferred quickly in cuvette, and absorbance is surveyed at 475nm.
Table 4
Reaction solution ingredient 1 group 2 groups 3 groups 4 groups
Sample solution/mL 0 0 1 1
Phosphate buffer solution/mL 2 2.5 1 1.5
DOPA solution/mL 1 1 1 1
Tyrosinase solution/mL 0.5 0 0.5 0
Total volume/mL 3.5 3.5 3.5 3.5
Sample is calculated to the relative inhibition of tyrosinase (I, abbreviation inhibiting rate, similarly hereinafter) by formula (1).
I=[(A1-A2)-(A3-A4)] × 100% ÷ (A1-A2) (1)
In formula: A1, A2, A3, A4 are respectively the absorbance of 1 group~4 groups solution.
3, inhibit B16 cell test in melanocyte
By B16 melanoma cells (mouse melanin tumor cell, Shanghai Cell Bank of the Chinese Academy of Sciences, model TCM2) with 1 ×105The density of a/mL is inoculated in 96 orifice plates, every hole 90 μ L, CO2After being incubated for 24 hours in incubator, it is molten that sample is added in every hole Liquid.The blank control group of culture medium and cell is set up simultaneously.
Culture plate is placed in incubator after being incubated for 72 hours, discards supernatant liquid, PBS is washed twice, and then every hole is added 0.5mL trypsin digestion cell 3min, every hole are added 2mL maintaining liquid and terminate digestion.After mixing, every kind of concentration takes out 0.5mL and runs business into particular one Born of the same parents count.Remaining cell suspension is centrifugated 5min with 2500r/min, discards supernatant liquid, NaOH solution is added in precipitating, add Heat dissolves melanin, and 490nm wavelength is selected to measure absorbance value under enzyme-linked immunosorbent assay instrument.Sample pair is calculated by formula (2) B16 cell inhibiting rate (I ').
I '=× 100% (2) (1-A5 ÷ P1/A6 ÷ P2)
In formula: A5 is sample solution hole absorbance value；P1 is sample solution hole cell density；A6 is control wells absorbance Value；P2 is control wells cell density.
4, ultra-oxygen anion free radical elimination effect evaluation test
Medical fluid is added by table 5.Sample solution 2mL is taken, is added 2.25mL Tris-HCl buffer solution (pH8.36), 0.25mL concentration is water-bath at 25 DEG C after 10mmoL/L pyrogallol solution, and 10mol/L hydrochloric acid 1 is added dropwise when 4min and drips, terminates Reaction.Absorbance value is surveyed at 420nm with ultraviolet specrophotometer.Clearance rate (D) is calculated according to formula (3).
× 100% (3) D=[1- (A9-A10) ÷ (A7-A8)]
In formula: A7, which issues for pyrogallol in Tris-HCl solution, is born from hair oxidation reaction generation O2 -Absorbance value；A8 For the absorbance value of Tris-HCl solution；A9 is to remove O2 -The absorbance value of reaction；A10 is the absorbance value of sample solution.
Table 5
Reaction group Tris-HCl Pyrogallol Sample solution Deionized water
F0 2.25mL 0.25mL 0mL 2mL
F1 2.25mL 0.25mL 2mL 0mL
F2 2.25mL 0mL 2mL 0mL
5, experimental result
The experiment of whitening anti-aging effect assessment is shown in Table 6.
Table 6
Table 6 the experimental results showed that, essential oil composition of the invention, which can have, to be inhibited tyrosinase activity and inhibits significantly B16 cell, the function of removing free radical, and in the case where total dosage is constant, essential oil composition of the invention compares single The composition and pure base oil effect of essential oil and base oil are obviously improved, and illustrate to have played synergistic work between different essential oils With.
3 skin irritation test of test example
Experimental material: embodiment 1, comparative example 1~7 is selected to be used as sample, after use, trier's skin contains comparative sample The variation of water.
Subject: totally 30 volunteers, wherein women: 20, male 10, the age was at 20~40 years old.
Test method: it takes 0.03mL sample to be placed in the coyote hole of spot examination adhesive tape with syringe, the spot of sample will be equipped with immediately Try that adhesive tape is longitudinal since lower part to be affixed on the normal skin of left forearm, while light pressing room and makes to try one by one to drive away air Object is tested to be uniformly distributed.Experiment position marks, to observe.It is primary every 24 hours patch skins, half an hour after patch is opened, Then checked according to the term of CTFA guide (1981).6 patch experiments have been carried out altogether, paste the 6th day after skin, In order to observe delayed response, additional inspection has been carried out.Data then utilize last time inspection result, compare.Identification with The following table 7 is standard progress:
7 skin irritatin standard of perfection of table
Grade Symbol Standard of perfection
0 - Negative reaction: non-stimulated, without erythema
1 ± Suspicious reaction: slight erythema
2 + Weakly positive reaction: erythema
3 ++ Strong positive reaction: erythema, papule, blister
4 +++ Extremely strong positive reaction: serious edema, bulla
Test result: as shown in table 8.
8 skin irritatin test result of table
Table 8 is the results show that 1 sample stimulus of the embodiment of the present invention is lower than 1~7 sample of comparative example.It follows that essential oil passes through After crossing science combination, under dosage unanimous circumstances, than milder is used alone.
4 anti-acne effect clinical test of test example
The sample of embodiment 1 and comparative example 1~7 carries out normal individual trial evaluation respectively.Choosing bilateral face has obvious acne, Be in newborn or inflammatory phase, and facial area skin belong to it is easily acne type volunteer 140 long, the age at 20~30 years old, male Female is fifty-fifty, is randomly divided into 7 groups, uses the sample of embodiment 1 and comparative example 1~7 respectively.Evaluation content is, to the white of volunteer Head acne, blackhead, papule, the acne of 5 ranks of tumour tubercle and warts carry out the label and number statistical of number.
Usage and dosage: volunteer is applied to affected part, and the area that application area is greater than illness is preferred, and respectively uses 1 time sooner or later, Test is paid a return visit for the 28th day (D28).
Experimental result: it according to the inhibitory effect to acne, collects half face and tests evaluation table on probation, statistical result is shown in Table 9.
9 normal individual trial evaluation result of table
Test result Embodiment 1 Comparative example 1 Comparative example 2 Comparative example 3 Comparative example 4 Comparative example 5 Comparative example 6 Comparative example 7
Whiteheads change rate - 47.3% - 39.2% - 16.7% - 30.1% - 12.3% - 13.6% - 18.4% - 6.0%
Blackhead change rate - 41.6% - 36.4% - 18.2% - 24.5% - 14.6% - 12.5% - 10.7% - 7.5%
Papule change rate - 39.7% - 26.8% - 16.8% - 21.7% - 11.8% - 10.7% - 9.8% - 4.3%
Tumour tubercle change rate - 17.3% - 12.3% - 15.0% - 10.3% - 8.0% - 6.0% - 10.0% - 12.0%
Warts change rate - 23.9% - 17.1% - 4.0% - 11.2% - 2.0% - 3.0% 4.3% 2.0%
Acne print color change rate - 37.4% - 9.4% - 7.5% - 6.0% - 32.6% - 34.5% - 16.7% - 19.6%
Anti-acne clinical evaluation has acne print color bright the results show that embodiment 1 has the inhibitory effect of highly significant to acne Aobvious improvement, becomes apparent from than 1~7 acne-removing of comparative example.It follows that essential oil is after science combination, it is consistent in dosage In the case where, than better effect is used alone, play synergistic function.
1 anti-acne of Application Example repairs essence cream
A kind of anti-acne reparation essence cream containing the essential oil composition with anti-acne and skin repair, the essence The specific formula of magnificent cream is as shown in table 10:
Table 10
Preparation method: weighing tetra- groups of raw materials of A, B, C, D, first by A group raw material, is uniformly mixed, is heated to 80 DEG C；Same B Group raw material is uniformly mixed, and is heated to 80 DEG C, B group material is added to A group later in expecting, with 4000r/min revolving speed homogeneous, 3~ 5min is kept the temperature after five minutes, after water-bath cooling cools to 30 DEG C~35 DEG C, to sequentially add C, D under 1000r/min stirring Phase materials, until stirring evenly.
The common essence cream of Comparison study example 1
Other than without containing essential oil composition (I) of the invention, other are consistent with Application Example 1.
2 anti-acne of Application Example repairs facial mask liquid
A kind of facial mask liquid containing the essential oil composition with anti-acne and skin repair, the tool of the facial mask liquid Body formula is as shown in table 11:
Table 11
Above-mentioned facial mask liquid, preparation method are as follows:
1, addition phase raw material methyl hydroxybenzoate and Nipasol are dissolved by heating into matter clear in 1,3-PD in advance, It is spare；
2, Aqueous Phase Raw Material is put into deionized water, is heated to 75~85 DEG C, stirring is to being uniformly dissolved；
3, water phase is cooled to 60 DEG C, is slowly added to the methyl hydroxybenzoate dissolved in 1,3-PD in advance while stirring And Nipasol, stirring is to being uniformly dissolved；
4,40 DEG C are cooled to, essential oil composition described in embodiment 1 (I) is added, then aminomethyl propanol is added dropwise and adjusts pH to 5 ~6；
5, it stirs evenly, is cooled to 35 DEG C, 300 mesh discharge after repetition measurement pH.
3 anti-acne of Application Example repairs essential oil
A kind of anti-acne reparation essential oil containing the essential oil composition with anti-acne and skin repair, the essential oil Specific formula it is as shown in table 12:
Table 12
Ingredient names Mass fraction (%)
Saualane 42
Caprylic/capric triglyceride 30
Isononyl isononanoate 14
Jojoba oil 4
Essential oil composition (I) of the present invention 10
Preparation method: the good each component raw material of formula rate weighing is successively pressed, is uniformly mixed at normal temperature.
The evaluation of 1 anti-acne effect of effect example
Evaluate sample: product prepared by Application Example 1 and Comparison study example 1.
Evaluation object: choosing bilateral face has obvious acne, is in newborn or inflammatory phase, and facial area skin belongs to easily It is acne type volunteer 40 long, wherein male 20, women 20.
Evaluation method: using double-blind study, and Application Example 1 and Comparison study example 1 is taken to prepare after daily morning and evening washed Product 3g is applied on the face the position for having acne respectively, and 1 product of Application Example applies left face, and 1 product of Comparison study example applies right face, 28 days as a treatment course.
Evaluation criterion: 1. effective: 70% or more acne fading, acne print is obviously thin out；2. effectively: acne fading 30% with On, acne print is thin out；3. invalid: acne fading 30% is hereinafter, acne print is unchanged.
Evaluation result: 1 product of Application Example effective 15,37.5% is accounted for；Effective 20, account for 50%；It invalid 5, accounts for 12.5%.Total effective rate reaches 90%.1 product of Comparison study example effective 0；Effective 2, account for 5%；Invalid 38, account for 95%. Total effective rate reaches 6%.The essence cream that this explanation is prepared with essential oil composition of the invention is to the good anti-acne effect of whelk.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention, It should be equivalent substitute mode, be included within the scope of the present invention.

Claims (10)

1. a kind of essential oil composition with anti-acne and skin repair, it is characterised in that: by the group of following weight percent Divide and be made: tea tree ethereal oil 0.05~15.0%；Essential Oil From Pine Needles 0.1~6.0%；Myrrh essential oil 0.1~7.0%；Angelica essential oil 0.05~6.0%；Peony essential oil 0.1~6.0%；Styrax essential oil 0.1~6.0%；Base oil is surplus.
2. the essential oil composition with anti-acne and skin repair according to claim 1, it is characterised in that: by as follows The component of weight percent is made: tea tree ethereal oil 1.0~10.0%；Essential Oil From Pine Needles 0.5~5.0%；Myrrh essential oil 0.2~ 5.0%；Angelica essential oil 0.5~5.0%；Peony essential oil 0.5~5.0%；Styrax essential oil 0.5~4.0%；Base oil is remaining Amount.
3. the essential oil composition with anti-acne and skin repair according to claim 1, it is characterised in that: by as follows The component of weight percent is made: tea tree ethereal oil 4.5~6.0%；Essential Oil From Pine Needles 1.0~2.0%；Myrrh essential oil 0.8~ 1.6%；Angelica essential oil 1.0~1.7%；Peony essential oil 1.0~2.0%；Styrax essential oil 1.0~1.5%；Base oil is remaining Amount.
4. described in any item essential oil compositions with anti-acne and skin repair, feature exist according to claim 1~3 In: the base oil is one of grape seed oil, wheat-germ oil, olive oil, jojoba oil or a variety of mixtures.
5. the described in any item essential oil compositions with anti-acne and skin repair of Claims 1 to 4 are preparing cosmetics In application.
6. application according to claim 5, it is characterised in that: the essential oil group with anti-acne and skin repair Close additive amount of the object in cosmetics is 0.1~25% based on mass fraction.
7. a kind of cosmetics with anti-acne and skin repair, it is characterised in that: contain any one of Claims 1 to 4 institute That states has effects that the essential oil composition of anti-acne and skin repair.
8. the cosmetics with anti-acne and skin repair according to claim 7, it is characterised in that:
The cosmetics contain the essential oil combination with anti-acne and skin repair for 0.1~25% based on mass fraction Object.
9. the cosmetics with anti-acne and skin repair according to claim 7 or 8, it is characterised in that:
The cosmetics are as follows: aqua, cream kind, facial mask, spray-like, essence class, essential oil class, soaps, washes shield class at type of latex type.
10. the cosmetics with anti-acne and skin repair according to claim 7 or 8, it is characterised in that:
The anti-acne repairs essence cream, the component including following mass fraction meter:
The anti-acne repairs facial mask, the component including following mass fraction meter:
The anti-acne repairs essential oil, the component including following mass fraction meter:
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