CN108473948A - 烟酰胺核糖苷的微生物生产 - Google Patents

烟酰胺核糖苷的微生物生产 Download PDF

Info

Publication number
CN108473948A
CN108473948A CN201680078334.8A CN201680078334A CN108473948A CN 108473948 A CN108473948 A CN 108473948A CN 201680078334 A CN201680078334 A CN 201680078334A CN 108473948 A CN108473948 A CN 108473948A
Authority
CN
China
Prior art keywords
leu
ala
gly
ile
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201680078334.8A
Other languages
English (en)
Chinese (zh)
Inventor
亚当·G·劳伦斯
席琳·维亚罗格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Publication of CN108473948A publication Critical patent/CN108473948A/zh
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/34—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Corynebacterium (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
    • C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
    • C12Y306/01022—NAD+ diphosphatase (3.6.1.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/01—Acid-ammonia (or amine)ligases (amide synthases)(6.3.1)
    • C12Y603/01005—NAD+ synthase (6.3.1.5)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201680078334.8A 2015-11-13 2016-11-14 烟酰胺核糖苷的微生物生产 Withdrawn CN108473948A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562254736P 2015-11-13 2015-11-13
US62/254,736 2015-11-13
PCT/US2016/061905 WO2017083858A2 (en) 2015-11-13 2016-11-14 Microbial production of nicotinamide riboside

Publications (1)

Publication Number Publication Date
CN108473948A true CN108473948A (zh) 2018-08-31

Family

ID=58695578

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680078334.8A Withdrawn CN108473948A (zh) 2015-11-13 2016-11-14 烟酰胺核糖苷的微生物生产

Country Status (7)

Country Link
US (1) US10913965B2 (https=)
EP (1) EP3374492A4 (https=)
JP (1) JP2019501638A (https=)
KR (1) KR20180083350A (https=)
CN (1) CN108473948A (https=)
BR (1) BR112018009393A8 (https=)
WO (1) WO2017083858A2 (https=)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112359082A (zh) * 2020-11-13 2021-02-12 南京工业大学 一种烟酰胺单核苷酸的制备方法
CN112795606A (zh) * 2021-04-14 2021-05-14 深圳瑞德林生物技术有限公司 一种β-烟酰胺单核苷酸的酶催化合成方法
CN112795582A (zh) * 2021-01-22 2021-05-14 江南大学 一种适合在微生物中高效合成nad衍生物的酶基因
CN113528562A (zh) * 2021-06-23 2021-10-22 苏州华赛生物工程技术有限公司 生产β-烟酰胺核糖的重组微生物及其构建方法和应用
CN113755415A (zh) * 2020-06-04 2021-12-07 苏州华赛生物工程技术有限公司 一种新的具有nmn合成路径的重组微生物及生产方法
CN113897382A (zh) * 2021-09-01 2022-01-07 浙江工业大学 辅酶自足型大肠杆菌及其构建方法与应用
CN114231477A (zh) * 2021-12-27 2022-03-25 天津科技大学 高产β-烟酰胺单核苷酸的基因工程菌株及其构建与应用
CN114854656A (zh) * 2022-05-05 2022-08-05 江南大学 一种产烟酰胺核糖苷的重组菌
CN118773286A (zh) * 2024-09-10 2024-10-15 中国科学院深圳先进技术研究院 用于检测qprt活性的组合物、qprt活性的检测方法与应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10913965B2 (en) * 2015-11-13 2021-02-09 Dsm Ip Assets B.V. Microbial production of nicotamide riboside
WO2018211028A1 (en) * 2017-05-18 2018-11-22 Dsm Ip Assets B.V. Microbial production of nicotinamide riboside
JP7203744B2 (ja) * 2017-09-29 2023-01-13 三菱ケミカル株式会社 ニコチンアミドモノヌクレオチドの製造方法およびその方法に用いる形質転換体
EP3877515A1 (en) * 2018-11-09 2021-09-15 Wageningen Universiteit Microbial hosts engineered for increased tolerance to temperature shifts
KR20220080075A (ko) * 2019-10-11 2022-06-14 고쿠리츠 다이가꾸 호우진 시즈오까 다이가꾸 니코틴아미드 리보시드를 산생하는 유산균, 및 니코틴아미드 모노뉴클레오티드 및 니코틴아미드 리보시드를 산생하는 유산균
CN112501193B (zh) * 2020-12-09 2022-09-27 江南大学 一种烟酸及烟酰胺生物传感系统
CN112852678B (zh) * 2021-03-08 2021-11-05 泓博元生命科技（深圳）有限公司 一株产烟酰胺单核苷酸的成都肠杆菌及其应用
CN112980906B (zh) * 2021-04-14 2021-07-30 深圳瑞德林生物技术有限公司 一种用于制备β-烟酰胺单核苷酸的酶组合物及其应用
JP7111878B1 (ja) 2021-10-27 2022-08-02 旭化成ファーマ株式会社 ニコチンアミドモノヌクレオチドの製造方法
CN116286725B (zh) * 2023-03-23 2025-12-12 赛诺根生物科学有限公司 一种催化性能提高的nadh焦磷酸酶突变体及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090202680A1 (en) * 2004-02-10 2009-08-13 Charles Brenner Yeast strain and method for using the same to produce nicotinamide riboside
CN102154339A (zh) * 2011-02-16 2011-08-17 南京工业大学 一种产丁二酸大肠杆菌基因工程菌株的构建方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015069860A1 (en) * 2013-11-06 2015-05-14 President And Fellows Of Harvard College Biological production of nad precursors and analogs
US10913965B2 (en) * 2015-11-13 2021-02-09 Dsm Ip Assets B.V. Microbial production of nicotamide riboside

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090202680A1 (en) * 2004-02-10 2009-08-13 Charles Brenner Yeast strain and method for using the same to produce nicotinamide riboside
CN102154339A (zh) * 2011-02-16 2011-08-17 南京工业大学 一种产丁二酸大肠杆菌基因工程菌株的构建方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GAZZANIGA F等: "Microbial NAD metabolism: lessons from comparative genomics", 《MICROBIOL MOL BIOL REV》 *
SORCI L等: "Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis", 《PROC NATL ACAD SCI U S A》 *
WANG L等: "Identification of UshA as a major enzyme for NAD degradation in Escherichia coli", 《ENZYME MICROB TECHNOL》 *
丁文成: "烟酸及异烟酸衍生物的合成及其缓蚀性能的研究", 《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》 *

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113755415A (zh) * 2020-06-04 2021-12-07 苏州华赛生物工程技术有限公司 一种新的具有nmn合成路径的重组微生物及生产方法
CN113755415B (zh) * 2020-06-04 2024-03-29 苏州华赛生物工程技术有限公司 一种新的具有nmn合成路径的重组微生物及生产方法
CN112359082A (zh) * 2020-11-13 2021-02-12 南京工业大学 一种烟酰胺单核苷酸的制备方法
CN112359082B (zh) * 2020-11-13 2023-02-21 南京工业大学 一种烟酰胺单核苷酸的制备方法
CN112795582B (zh) * 2021-01-22 2022-12-13 江南大学 一种适合在微生物中高效合成nad衍生物的酶基因
CN112795582A (zh) * 2021-01-22 2021-05-14 江南大学 一种适合在微生物中高效合成nad衍生物的酶基因
CN112795606A (zh) * 2021-04-14 2021-05-14 深圳瑞德林生物技术有限公司 一种β-烟酰胺单核苷酸的酶催化合成方法
CN113528562A (zh) * 2021-06-23 2021-10-22 苏州华赛生物工程技术有限公司 生产β-烟酰胺核糖的重组微生物及其构建方法和应用
CN113897382B (zh) * 2021-09-01 2023-10-20 浙江工业大学 辅酶自足型大肠杆菌及其构建方法与应用
CN113897382A (zh) * 2021-09-01 2022-01-07 浙江工业大学 辅酶自足型大肠杆菌及其构建方法与应用
CN114231477A (zh) * 2021-12-27 2022-03-25 天津科技大学 高产β-烟酰胺单核苷酸的基因工程菌株及其构建与应用
CN114231477B (zh) * 2021-12-27 2024-03-15 天津科技大学 高产β-烟酰胺单核苷酸的基因工程菌株及其构建与应用
CN114854656A (zh) * 2022-05-05 2022-08-05 江南大学 一种产烟酰胺核糖苷的重组菌
CN114854656B (zh) * 2022-05-05 2023-07-18 江南大学 一种产烟酰胺核糖苷的重组菌
CN118773286A (zh) * 2024-09-10 2024-10-15 中国科学院深圳先进技术研究院 用于检测qprt活性的组合物、qprt活性的检测方法与应用

Also Published As

Publication number Publication date
WO2017083858A3 (en) 2017-06-29
US10913965B2 (en) 2021-02-09
BR112018009393A8 (pt) 2019-02-26
WO2017083858A2 (en) 2017-05-18
US20180327797A1 (en) 2018-11-15
EP3374492A4 (en) 2019-07-24
EP3374492A2 (en) 2018-09-19
BR112018009393A2 (pt) 2018-11-13
JP2019501638A (ja) 2019-01-24
KR20180083350A (ko) 2018-07-20

Similar Documents

Publication Publication Date Title
CN108473948A (zh) 烟酰胺核糖苷的微生物生产
DK2665809T3 (en) Microorganism with increased L-amino acid productivity and method for producing L-amino acids using the same
DK2239336T3 (en) Microorganism for Preparation of L-Amino Acids and Process for Preparation of L-Amino Acids Using the Same
US20200362381A1 (en) Microbial production of nicotinamide riboside
US20190071680A1 (en) Microbial production of nicotinic acid riboside
US20200255877A1 (en) Microbial production of nicotinamide riboside
KR20130082124A (ko) 자일로즈 이용능이 부여된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-라이신의 생산방법
JP7497348B2 (ja) リボフラビンの改善された産生
KR20230006803A (ko) 미생물 공정을 통한 nmn 및 이의 유도체 생산
KR102078732B1 (ko) 변형된 막 투과성
EP3078737A1 (en) Corynebacterium genus microorganism with improved ability to produce l-lysine and method for producing l-lysine using same
WO2012025780A1 (en) Improved glycolic acid fermentative production with a modified microorganism
US20150211035A1 (en) Biological method for producing cis-5-hydroxy-l-pipecolic acid
US20150037850A1 (en) Recombinant microorganism producing quinolinic acid and a method for producing quinolinic acid using the same
DK2430152T3 (en) A microorganism with increased L-lysine productivity and method for producing L-lysine using the same
JP5230447B2 (ja) 新規方法
US8859244B2 (en) Method of L-lysine production
CN111770993A (zh) 调节csr系统以生产赖氨酸和赖氨酸衍生产物
JP6697525B2 (ja) キノリン酸を生産する組み換え微生物、及びそれを利用したキノリン酸の生産方法
EP4555076A1 (en) Microbial cell factories producing thiamine
KR101320039B1 (ko) 써모코코스 코닥카렌시스 ｋｏｄ1로부터 분리한 글루탐산 탈탄산효소 및 이를 이용한 고순도 가바의 제조방법.
KR20240086806A (ko) 퓨린 뉴클레오티드를 생산하는 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법
KR20240086803A (ko) 퓨린 뉴클레오티드를 생산하는 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법
CN114269909A (zh) 新型可溶性吡啶核苷酸转氢酶变体及使用其生产l-色氨酸的方法

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20180831