CN108434214A - 一种肠胃调理药物及其制备方法 - Google Patents
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Abstract
本发明公开了一种肠胃调理药物及其制备方法，将山樟子、红枣、太子参、红糖、蓖麻油与水煮沸制提取液，然后将提取液与γ‑氨基丁酸、姜黄素、黄原胶、乙基纤维素、羟丙基纤维素通过熔融、挤出、压片制得片剂。制得的药物能够调理肠胃，安全性高，同时对痢疾有显效，本发明将γ‑氨基丁酸与山樟子、姜黄素联合使用，能够有效增强其功能活性。
Description
技术领域
本发明涉及一种肠胃调理的药物及该药物的制备方法，属于生物技术领域。
背景技术
γ-氨基丁酸，英文名：γ-aminobutyric acid (GABA)，化学名称：4-氨基丁酸，别名：γ-氨基丁酸，氨酪酸，哌啶酸。分子式：C4H9NO2。分子量：103.1。GABA是目前研究较为深入的一种重要的抑制性神经递质，它参与多种代谢活动，具有很高的生理活性。具有镇静、抗应激、促进食欲、调节内分泌等多种生物学功能。2009年9月27日，卫生部批准γ-氨基丁酸等六种物质为新资源食品，充分说明了γ-氨基丁酸极高的生物安全性。将γ-氨基丁酸应用于保健品、药品，用于改善肠胃功能是一个热门且意义重大的研究课题。本发明发现将γ-氨基丁酸与山樟子、姜黄素联合使用，能够有效增强其功能活性。
熔融挤压法创造性的将加工技术和药学结合起来，将高分子材料在玻璃化转变温度之上对其进行处理，促使热塑性粘合剂或聚合物、药物活性成分达到分子水平的有效混合。热熔挤出技术结合了固体分散体技术和机械制备的诸多优势，实现了无粉尘、连续化操作、良好的重现性、极高的生产效率和在线监测。不仅可以促进难溶性活性成分溶解从而提高其生物利用度，还可用于制备缓控释、肠溶制剂；此外，这一技术还能用于制备掩味微丸或者其它特殊形状的制剂，如膜剂、棒剂和空心圆柱剂型等。由于整个挤出过程持续时间很短且无须加入水或有机溶剂，不需加热干燥，因此不易发生水解问题。自从首次被应用于药物制剂领域开始，其完美解决传统制药工艺存在的诸多问题，已经成为国内外研究的热点技术。
发明内容
本发明的目的在于提供一种肠胃调理的药物及该药物的制备方法，制得的药物能够调理肠胃，安全性高，同时对痢疾有显效，本发明将γ-氨基丁酸与山樟子、姜黄素联合使用，能够有效增强其功能活性。
为实现上述目的，本发明采用如下技术方案：
取山樟子10g，红枣5g，太子参5g，红糖3g，蓖麻油2mL，加水200mL沸水蒸煮30min，过滤除渣，滤液加热浓缩至30mL,得到提取液。
在提取液中加入γ-氨基丁酸1-3g、姜黄素1-2g，溶解搅拌均匀，再与黄原胶5-10g、乙基纤维素5-25g、羟丙基纤维素 50-80g混合，混合后送入热熔挤出机，在热熔挤出机内进行加热熔融、挤出。热熔挤出机各区的温度设定为：喂料温度25-40℃，传输区温度35-60℃，混合区一段温度50-90℃，混合区二段温度80-140℃，混合区三段温度70-130℃，脱气区温度70-130℃，挤出区温度70-130℃。压片制成600mg片剂。
本发明的有益效果：调理肠胃，安全性高，同时对痢疾有显效。本发明将γ-氨基丁酸与山樟子、姜黄素联合使用，能够有效增强其功能活性。
具体实施方式
本发明用下列实施例来进一步说明本发明，但本发明的保护范围并不限于下列实施例。
实施例1
一种肠胃调理药物的制备方法，包括以下步骤：
（1）取山樟子10g，红枣5g，太子参5g，红糖3g，蓖麻油2mL，加水200mL沸水蒸煮30min，过滤除渣，滤液加热浓缩至30mL，得到提取液。
（2）在提取液中加入γ-氨基丁酸1g、姜黄素2g，溶解搅拌均匀，再与黄原胶7g、乙基纤维素15g、羟丙基纤维素 60g混合，混合后送入热熔挤出机，在热熔挤出机内进行加热熔融、挤出。热熔挤出机各区的温度设定为：喂料温度30℃，传输区温度50℃，混合区一段温度75℃，混合区二段温度115℃，混合区三段温度105℃，脱气区温度90℃，挤出区温度90℃。压片制成600mg片剂。
实施例2（最佳方案）
一种肠胃调理药物的制备方法，包括以下步骤：
（1）取山樟子10g，红枣5g，太子参5g，红糖3g，蓖麻油2mL，加水200mL沸水蒸煮30min，过滤除渣，滤液加热浓缩至30mL，得到提取液。
（2）在提取液中加入γ-氨基丁酸2g、姜黄素1.5g，溶解搅拌均匀，再与黄原胶8g、乙基纤维素25g、羟丙基纤维素 52.5g混合，混合后送入热熔挤出机，在热熔挤出机内进行加热熔融、挤出。热熔挤出机各区的温度设定为：喂料温度25℃，传输区温度45℃，混合区一段温度70℃，混合区二段温度115℃，混合区三段温度110℃，脱气区温度100℃，挤出区温度85℃。压片制成600mg片剂。
实施例3
一种肠胃调理药物的制备方法，包括以下步骤：
（1）取山樟子10g，红枣5g，太子参5g，红糖3g，蓖麻油2mL，加水200mL沸水蒸煮30min，过滤除渣，滤液加热浓缩至30mL，得到提取液。
（2）在提取液中加入γ-氨基丁酸3g、姜黄素1g，溶解搅拌均匀，再与黄原胶7g、乙基纤维素20g、羟丙基纤维素60g混合，混合后送入热熔挤出机，在热熔挤出机内进行加热熔融、挤出。热熔挤出机各区的温度设定为：喂料温度25℃，传输区温度45℃，混合区一段温度65℃，混合区二段温度125℃，混合区三段温度125℃，脱气区温度105℃，挤出区温度95℃。压片制成600mg片剂。
选择大约20g左右昆明种小鼠为实验对象，分两组，每组10只小鼠。试验组每天喂食实施例2所述片剂1次，每次喂食量为0.4mg/10g小鼠体重，连续喂食15天。对照组喂食等量饲料。然后给予营养性半固体黑色糊，观察小鼠胃排空，小肠推进运动的影响。与对照组相比，实验组小肠推进率提高了36.7%，胃内容物残留率显著降低。
以上所述仅为本发明的较佳实施案例，凡依本发明申请专利范围所做的均等变化与修饰，皆应属本发明的涵盖范围。
Claims (3)
1.一种肠胃调理药物的制备方法，其特征在于：包括以下步骤：
（1）取山樟子10g，红枣5g，太子参5g，红糖3g，蓖麻油2mL，加入200mL沸水蒸煮30min，过滤除渣，滤液浓缩至30mL，得到提取液；
（2）在提取液中加入γ-氨基丁酸1-3g、姜黄素1-2g，溶解搅拌均匀，再与黄原胶5-10g、乙基纤维素5-25g、羟丙基纤维素 50-80g混合，混合后送入热熔挤出机，在热熔挤出机内进行加热熔融、挤出，压片制成600mg片剂。
2.根据权利要求1所述的制备方法，其特征在于：热熔挤出机各区的温度设定为：喂料温度25-40℃，传输区温度35-60℃，混合区一段温度50-90℃，混合区二段温度80-140℃，混合区三段温度70-130℃，脱气区温度70-130℃，挤出区温度70-130℃。
3.如权利要求1或2所述的制备方法制得的肠胃调理药物。
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