CN108478627A - 一种解酒药物及其制备方法 - Google Patents
一种解酒药物及其制备方法 Download PDFInfo
- Publication number
- CN108478627A CN108478627A CN201810463842.9A CN201810463842A CN108478627A CN 108478627 A CN108478627 A CN 108478627A CN 201810463842 A CN201810463842 A CN 201810463842A CN 108478627 A CN108478627 A CN 108478627A
- Authority
- CN
- China
- Prior art keywords
- temperature
- parts
- antialcoholic drugs
- vitamin
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 17
- 229940079593 drug Drugs 0.000 title claims abstract description 15
- 230000002075 anti-alcohol Effects 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract description 26
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims abstract description 12
- 239000012943 hotmelt Substances 0.000 claims abstract description 11
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 claims abstract description 9
- 240000007817 Olea europaea Species 0.000 claims abstract description 9
- 229930003270 Vitamin B Natural products 0.000 claims abstract description 9
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 9
- 239000011720 vitamin B Substances 0.000 claims abstract description 9
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims abstract description 8
- 229920000377 Sinistrin Polymers 0.000 claims abstract description 8
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 229920001285 xanthan gum Polymers 0.000 claims abstract description 8
- 239000011435 rock Substances 0.000 claims abstract description 7
- 235000019325 ethyl cellulose Nutrition 0.000 claims abstract description 6
- 229920001249 ethyl cellulose Polymers 0.000 claims abstract description 6
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims abstract description 5
- 239000002994 raw material Substances 0.000 claims abstract description 4
- 239000001856 Ethyl cellulose Substances 0.000 claims abstract description 3
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims abstract description 3
- 239000012141 concentrate Substances 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 241000219109 Citrullus Species 0.000 claims description 8
- 238000001125 extrusion Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 238000002844 melting Methods 0.000 claims description 6
- 230000008018 melting Effects 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 5
- 238000007872 degassing Methods 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 239000002245 particle Substances 0.000 claims description 5
- 239000002893 slag Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 229920002678 cellulose Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 235000010980 cellulose Nutrition 0.000 claims description 2
- 230000035622 drinking Effects 0.000 abstract description 3
- 206010025482 malaise Diseases 0.000 abstract description 2
- 208000024891 symptom Diseases 0.000 abstract description 2
- 244000241235 Citrullus lanatus Species 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 5
- 238000012360 testing method Methods 0.000 description 3
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 235000020097 white wine Nutrition 0.000 description 2
- XJLSEXAGTJCILF-RXMQYKEDSA-N (R)-nipecotic acid zwitterion Chemical compound OC(=O)[C@@H]1CCCNC1 XJLSEXAGTJCILF-RXMQYKEDSA-N 0.000 description 1
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 1
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000023852 carbohydrate metabolic process Effects 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000004126 nerve fiber Anatomy 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000004783 oxidative metabolism Effects 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种解酒药物及其制备方法，其是以山樟子、去核橄榄、西瓜皮、冰糖、γ‑氨基丁酸、维生素B、多聚果糖、黄原胶、乙基纤维素、羟丙基纤维素为原料，经提取、浓缩、混合、热熔挤出、压片制得所述解酒药物。本发明将γ‑氨基丁酸与山樟子、维生素B、多聚果糖等联合使用，使所得解酒药物可显著缓解酒后不适症状。
Description
技术领域
本发明属于保健药品技术领域，具体涉及一种解酒药物及其制备方法。
背景技术
γ-氨基丁酸(GABA)，又称4-氨基丁酸、氨酪酸、哌啶酸，其分子式为C4H9NO2，是目前研究较为深入的一种重要的抑制性神经递质，它参与多种代谢活动，具有镇静、抗应激、促进食欲、调节内分泌等多种生物学功能。2009年9月27日，卫生部批准γ-氨基丁酸等六种物质为新资源食品，充分说明了γ-氨基丁酸极高的生物安全性。将γ-氨基丁酸应用于保健品、药品是一个具有重大应用价值的研究课题。
熔融挤压法创造性的将加工技术和药学结合起来，将高分子材料在玻璃化转变温度之上进行处理，以促使热塑性粘合剂或聚合物、药物活性成分达到分子水平的有效混合。熔融挤压技术结合了固体分散体技术和机械制备的诸多优势，实现了无粉尘、连续化操作、良好的重现性、极高的生产效率和在线监测，不仅可以促进难溶性活性成分溶解，从而提高其生物利用度，还可用于制备缓控释、肠溶制剂；此外，这一技术还能用于制备掩味微丸或者其它特殊形状的制剂，如膜剂、棒剂和空心圆柱剂型等。由于整个挤出过程持续时间很短且无须加入水或有机溶剂，不需加热干燥，因此不易发生水解问题。自从首次被应用于药物制剂领域开始，其完美解决了传统制药工艺存在的诸多问题，已经成为国内外研究的热点技术。
发明内容
本发明的目的在于提供一种解酒药物及其制备方法，其可显著缓解酒后不适症状。
为实现上述目的，本发明采用如下技术方案：
一种解酒药物，其所用原料按重量份计包括山樟子10份、去核橄榄5份、西瓜皮5份、冰糖3份、γ-氨基丁酸1-3份、维生素B 0.5-1份、多聚果糖3-5份、黄原胶5-10份、乙基纤维素15-25份、羟丙基纤维素50-80份。
所述解酒药物的制备方法包括以下步骤：
1）将山樟子、去核橄榄、西瓜皮、冰糖加水煎煮30min，过滤除渣，所得提取液加热浓缩至原体积的15%，得到浓缩液；
2）在所得浓缩液中加入γ-氨基丁酸、维生素B搅拌溶解，再加入多聚果糖、黄原胶、乙基纤维素、羟丙基纤维素混合后送入热熔挤出机进行加热熔融、挤出；
3）挤出颗粒经压片制成片剂。
热熔挤出机中各区段的温度设定为：喂料温度25-40℃，传输区温度35-60℃，混合区一段温度50-90℃，混合区二段温度80-140℃，混合区三段温度70-130℃，脱气区温度70-130℃，挤出区温度70-130℃。
本发明以山樟子、去核橄榄、西瓜皮等为原料制得的解酒药物具有提高乙醇脱氢酶活性、加速乙醇氧化代谢的作用，同时其可增加消化液分泌、加速胃肠蠕动、增强糖代谢，减少神经组织中丙酮酸、乳酸堆积，维持人体正常血糖水平，故可显著缓解酒后不适症状。
具体实施方式
为了使本发明所述的内容更加便于理解，下面结合具体实施方式对本发明所述的技术方案做进一步的说明，但是本发明不仅限于此。
实施例1
1）将山樟子10 g、去核橄榄5 g、西瓜皮5 g、冰糖3 g加200mL水煎煮30min，过滤除渣，所得提取液加热浓缩至30mL，得到浓缩液；
2）在所得浓缩液中加入1 gγ-氨基丁酸、1 g维生素B搅拌溶解，再加入5 g多聚果糖、7g黄原胶、15 g乙基纤维素、60 g羟丙基纤维素混合后送入热熔挤出机进行加热熔融、挤出；热熔挤出机中各区段的温度设定为：喂料温度30℃，传输区温度50℃，混合区一段温度75℃，混合区二段温度115℃，混合区三段温度105℃，脱气区温度90℃，挤出区温度90℃；
3）挤出颗粒经压片制成片剂。
实施例2
1）将山樟子10 g、去核橄榄5 g、西瓜皮5 g、冰糖3 g加200mL水煎煮30min，过滤除渣，所得提取液加热浓缩至30mL，得到浓缩液；
2）在所得浓缩液中加入2 gγ-氨基丁酸、1 g维生素B搅拌溶解，再加入4 g多聚果糖、8g黄原胶、25 g乙基纤维素、52.5 g羟丙基纤维素混合后送入热熔挤出机进行加热熔融、挤出；热熔挤出机中各区段的温度设定为：喂料温度25℃，传输区温度45℃，混合区一段温度70℃，混合区二段温度115℃，混合区三段温度110℃，脱气区温度100℃，挤出区温度85℃；
3）挤出颗粒经压片制成片剂。
实施例3
1）将山樟子10 g、去核橄榄5 g、西瓜皮5 g、冰糖3 g加200mL水煎煮30min，过滤除渣，所得提取液加热浓缩至30mL，得到浓缩液；
2）在所得浓缩液中加入3 gγ-氨基丁酸、0.5 g维生素B搅拌溶解，再加入3 g多聚果糖、7 g黄原胶、20 g乙基纤维素、60 g羟丙基纤维素混合后送入热熔挤出机进行加热熔融、挤出；热熔挤出机中各区段的温度设定为：喂料温度25℃，传输区温度45℃，混合区一段温度65℃，混合区二段温度125℃，混合区三段温度125℃，脱气区温度105℃，挤出区温度95℃；
3）挤出颗粒经压片制成片剂。
将20只昆明种小鼠（体重20±2g）随机分为两组，每组10只。试验组喂食实施例2所得片剂，喂食量为0.4mg/10g小鼠体重，对照组喂食等量饲料，2小时后同时灌胃给予0.2mL/10g体重的白酒，白酒度数为42°。灌胃后30min进行水迷宫试验，记录小鼠穿越迷宫的时间。结果显示，试验组平均所用时间约为67.19s，对照组平均所用时间约为96.35s，即试验组所用比对照组约少30%。
以上所述仅为本发明的较佳实施例，凡依本发明申请专利范围所做的均等变化与修饰，皆应属本发明的涵盖范围。
Claims (3)
1. 一种解酒药物，其特征在于：所用原料按重量份计包括山樟子10份、去核橄榄5份、西瓜皮5份、冰糖3份、γ-氨基丁酸1-3份、维生素B 0.5-1份、多聚果糖3-5份、黄原胶5-10份、乙基纤维素15-25份、羟丙基纤维素50-80份。
2.一种如权利要求1所述的解酒药物的制备方法，其特征在于：包括以下步骤：
1）将山樟子、去核橄榄、西瓜皮、冰糖加水煎煮30min，过滤除渣，所得提取液加热浓缩至原体积的15%，得到浓缩液；
2）在所得浓缩液中加入γ-氨基丁酸、维生素B搅拌溶解，再加入多聚果糖、黄原胶、乙基纤维素、羟丙基纤维素混合后送入热熔挤出机进行加热熔融、挤出；
3）挤出颗粒经压片制成片剂。
3.根据权利要求2所述的解酒药物的制备方法，其特征在于：热熔挤出机中各区段的温度设定为：喂料温度25-40℃，传输区温度35-60℃，混合区一段温度50-90℃，混合区二段温度80-140℃，混合区三段温度70-130℃，脱气区温度70-130℃，挤出区温度70-130℃。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810463842.9A CN108478627A (zh) | 2018-05-15 | 2018-05-15 | 一种解酒药物及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810463842.9A CN108478627A (zh) | 2018-05-15 | 2018-05-15 | 一种解酒药物及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108478627A true CN108478627A (zh) | 2018-09-04 |
Family
ID=63354305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810463842.9A Pending CN108478627A (zh) | 2018-05-15 | 2018-05-15 | 一种解酒药物及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108478627A (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070360A (zh) * | 2013-01-24 | 2013-05-01 | 普定县朵贝金苑茶厂 | 一种橄榄制剂 |
| CN105901603A (zh) * | 2016-04-15 | 2016-08-31 | 蒋灵锟 | 一种解酒果酱及其制备方法 |
| CN106235327A (zh) * | 2016-07-14 | 2016-12-21 | 万光瑞 | 一种适时解酒、护胃、护肝、护脑组合物及其应用 |
-
2018
- 2018-05-15 CN CN201810463842.9A patent/CN108478627A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103070360A (zh) * | 2013-01-24 | 2013-05-01 | 普定县朵贝金苑茶厂 | 一种橄榄制剂 |
| CN105901603A (zh) * | 2016-04-15 | 2016-08-31 | 蒋灵锟 | 一种解酒果酱及其制备方法 |
| CN106235327A (zh) * | 2016-07-14 | 2016-12-21 | 万光瑞 | 一种适时解酒、护胃、护肝、护脑组合物及其应用 |
Non-Patent Citations (4)
| Title |
|---|
| 曾培杰 等: "《小郎中学医记.药性赋白话讲记.3》", 31 October 2015, 人民军医出版社 * |
| 熊龙启 等: "熔融挤压法在工业药剂中的应用", 《中国医药工业杂志》 * |
| 石四维: "《怎样吃水果》", 21 December 2016, 上海科学技术文献出版社 * |
| 肖小河 等: "《中国军事本草》", 31 July 2012, 人民军医出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zhou et al. | The polysaccharides from the fruits of Lycium barbarum L. confer anti-diabetic effect by regulating gut microbiota and intestinal barrier | |
| JP4963738B2 (ja) | アルクチゲニン高含有ゴボウシエキス及びその製造方法 | |
| CN103768112B (zh) | 一种芒果叶提取物及其应用 | |
| US20160158174A1 (en) | Enteric-Coated Functional Food Ingredients And Methods For Making The Enteric-Coated Functional Food Ingredients | |
| CN104987422A (zh) | 用氨基酸修饰的玉米淀粉衍生物的制备方法 | |
| CN101773244B (zh) | 一种制备水溶性功能性红曲的方法及其制品 | |
| JP2013525269A5 (zh) | ||
| CA3135622A1 (en) | Method of producing bacterially derived indole-3-propionic acid and compositions comprising same | |
| Lu et al. | Antidiabetic effects of the Auricularia auricular polysaccharides simulated hydrolysates in experimental type-2 diabetic rats | |
| JP5924592B2 (ja) | 抗疲労用組成物 | |
| CN105769928B (zh) | 丁酸梭状芽孢杆菌在防治或辅助治疗高血糖制剂中的应用 | |
| CN108478627A (zh) | 一种解酒药物及其制备方法 | |
| Martellet et al. | Probiotic applications associated with Psyllium fiber as prebiotics geared to a healthy intestinal microbiota: A review | |
| CN106889625A (zh) | 一种菊粉颗粒的制备方法 | |
| CN1628845A (zh) | 一种具有生物活性的复方药物制剂 | |
| CN113260635B (zh) | 寡糖组合物及其使用方法 | |
| CN108294211A (zh) | 一种含有萝卜硫苷的功能性固体饮料及其制备方法 | |
| CN108379259A (zh) | 一种精神焦虑缓解药物及其制备方法 | |
| CN108434214A (zh) | 一种肠胃调理药物及其制备方法 | |
| JP5713332B2 (ja) | 抗疲労用組成物 | |
| CN110903413A (zh) | 一种改善功能性消化不良的菊芋粕菊粉及其制备方法和应用 | |
| CN105725185A (zh) | 具有降血压功能的益生菌组合物及其制备方法与应用 | |
| CN106619667B (zh) | 一种乙酰天麻素和乙酰天麻素衍生物的应用 | |
| CN104857180B (zh) | 抗疲劳及提高免疫力的组合物及其制备方法和应用 | |
| CN108379351A (zh) | 一种降血压药物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180904 |