CN108379109A - Sardine small-molecular peptides skin cream and preparation method thereof - Google Patents
Sardine small-molecular peptides skin cream and preparation method thereof Download PDFInfo
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- CN108379109A CN108379109A CN201810359069.1A CN201810359069A CN108379109A CN 108379109 A CN108379109 A CN 108379109A CN 201810359069 A CN201810359069 A CN 201810359069A CN 108379109 A CN108379109 A CN 108379109A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/522—Antioxidants; Radical scavengers
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Abstract
The present invention provides a kind of sardine small-molecular peptides skin cream, and by weight percentage, the skin cream includes mainly following components：Sardine small-molecular peptides 0.4 2%, oil phase 15 30%, water phase 60 80% and emulsifier 3 5%.The sardine small-molecular peptides skin cream of the present invention has the clearance rate of higher hydroxy radical and ultra-oxygen anion free radical, high moisturizing rate, illustrates that the present invention has good antioxygenic property, moistening effect.Moreover, stability of the present invention is good, texture uniform and smooth.It is simple for process the present invention also provides the preparation method of above-mentioned sardine small-molecular peptides skin cream, the good moisturizing of prepared skin cream and anti-oxidation function and have the advantages of good stability, texture uniform and smooth.
Description
Technical field
The invention belongs to cosmetic technical fields, more particularly to a kind of sardine small-molecular peptides skin cream and its preparation side
Method.
Background technology
Skin is the outermost tissue of human body, and the water content of normal skin cuticula, which is 10%-20%, can just make skin table
Face is moist, smooth, flexible, maintains the normal water content of keratoderma to maintaining healthy skin, moisturizes the skin, prevent skin
Skin aging plays an important role.Therefore, moisturizing is carried out to skin to play an important role to the aging of delaying skin.In addition, freely
Base is also the one of the major reasons for leading to skin aging, and free radical is that the one kind generated during organism metabolism carries
There is unpaired electron the active atom of high oxidation or molecule, the experimental results to show when savings is excessive certainly in human body
When by base, its energy damaging cells leads to the oxidation of cell, causes lipid and protein on cell membrane to be damaged, cause film
The disorder that inside and outside calcium ion plasma exchanges, and this process further accelerates the generation of free radical, forms vicious circle.
Its external manifestation is cutis laxa, and wrinkle is deepened, and skin tarnishes with elasticity etc..Anti-oxidant is exactly that confrontation or removing are free
Base makes cell break away from the process of damage.
As the improvement of people's living standards, it is essential to have become them with the anti-oxidant cosmetics with moisture-keeping functions
A part.However chemically synthesized antioxidant such as BHT, BHA etc. are harmful to the body of people in production and processing at present.Cause
This, there is an urgent need for develop a kind of to use natural active matter for raw material, have both anti-oxidant and heat insulation function skin care item.
It is well known that not only the earth is the Source of life of all things on earth on the earth for ocean, but also it is that living resources are most rich on the earth
Rich field, and China is ocean big country, is removed outside the biologies such as our well known fish, shrimp, shellfishes, the life of only more low ocean
Object species just have tens thousand of kinds.Due to the diversity of marine organisms, there is many activity uniquenesses, structure are new in the vast oceans
The metabolite of grain husk.In recent years, more and more scientists pay close attention to marine natural products.Now, people give birth to from ocean
Tens thousand of kinds of new compounds, including the classes such as macrolides, polypeptide, protein-based, polysaccharide, alkaloids are isolated in object
Type, peptides are the most huge a kind of compounds of quantity in marine biomaterial.
Fish are one of the marine organisms that people eat earliest, have abundant protein.According to geographical location, Chinese face
Face the Pacific Ocean, close on the Indian Ocean, convenient for developing and using deep-sea fishing resource, deep-sea fishing job area has been directed to the world three at present
Ocean have preliminarily formed industrial system, become the important component of Chinese Sea fishery.So with scientific and technological progress and life
The flat raising of running water, more and more human hairs excavate other the significant purposes of sardine other than eating.
The present invention prepares skin cream using sardine small-molecular peptides as natural active matter, with good moisturizing and antioxygen
Change function.
Invention content
The purpose of the present invention is to provide a kind of sardine small-molecular peptides skin cream, the skin cream have good moisturizing and
Anti-oxidation function and has the advantages of good stability, texture uniform and smooth.
Another object of the present invention is to provide a kind of preparation methods of above-mentioned sardine small-molecular peptides skin cream.
To achieve the goals above, the present invention uses technical solution below：
A kind of sardine small-molecular peptides skin cream, by weight percentage, the skin cream include mainly following components：It is husky
Fourth fish small-molecular peptides 0.4-2%, oil phase 15-30%, water phase 60-80% and emulsifier 3-5%.
For the additive amount of sardine small-molecular peptides, inventor has found when sardine small-molecular peptides weight fraction in skin cream
When more than 2%, just it is easy to appear layerings at normal temperatures.Therefore, in skin cream sardine small-molecular peptides weight fraction highest
It is 2%.
Preferably, when adding the sardine small-molecular peptides, using a concentration of 0.7% sardine small-molecular peptides solution.
Preferably, sardine small-molecular peptides skin cream of the invention, by weight percentage, the skin cream includes mainly
Following components：Sardine small-molecular peptides 0.5-1%, oil phase 20-25%, water phase 65-75% and emulsifier 3-5%.
Particularly preferred, of the invention sardine small-molecular peptides skin cream, by weight percentage, the skin cream is main
Including following components：Sardine small-molecular peptides 0.7%, oil phase 20-25%, water phase 65-75% and emulsifier 3-5%.
Preferably, the sardine small-molecular peptides are extracted from fish-skin, the fish-bone of sardine.
Preferably, the sardine small-molecular peptides have 3-6 amino acid.
Preferably, the molecular weight of the sardine small-molecular peptides is less equal than 3000 dalton.
Preferably, the oil phase is selected from cetostearyl alcohol, White Mineral Oil, silicone oil, beeswax, olive oil, shea butter, all scholars
Any one or more mixing in woods, caprylic/capric triglyceride.
Particularly preferred, the oil phase is made of cetostearyl alcohol, White Mineral Oil, silicone oil, beeswax and olive oil.
Preferably, the water phase be selected from water, glycerine, propylene glycol, 1,3- succinic acid, allantoin, it is any in sorbic acid or
Two or more mixing.
Particularly preferred, the water phase is made of water, glycerine, propylene glycol.
Preferably, the emulsifier is selected from sorbitan monostearate, Tween-60, monoglyceride, alkyl glycosides, alkyl
It is any or two in phosphate kalium salt, fatty alcohol polyoxyethylene ether, potassium alkyl phosphate, lauryl sodium sulfate, xanthans
Kind or more mixing.
Particularly preferred, the emulsifier is by sorbitan monostearate, Tween-60, monoglyceride, dodecyl sulphate
Sodium, xanthans composition.
The sardine small-molecular peptides skin cream of the present invention, by weight percentage, the skin cream also include following components：
Auxiliary agent 0.1-5%；The auxiliary agent is one or more mixtures in preservative, essence, pigment.
Preferably, the preservative is PE9010.
Preferably, the essence includes the fragrance component suitable for cosmetics, as melon and fruit is fragrant, the fragrance of flowers and plants perfume (or spice) class.Institute
It includes the dyestuff for being useful in cosmetics, pigment to state pigment.
In addition, the preparation method of above-mentioned sardine small-molecular peptides skin cream, this approach includes the following steps：
(1) oil phase and the emulsifier in addition to lauryl sodium sulfate and xanthans are mixed, is 75-80 DEG C in temperature
Under the conditions of, it is evenly stirred until and is completely dissolved, A phases are made；
(2) water phase and xanthans are mixed, under conditions of temperature is 75-80 DEG C, is evenly stirred until after being completely dissolved, drops
Lauryl sodium sulfate is added in low mixing speed, and B phases are made；
(3) A phases are slowly added drop-wise in B phases, are stirred evenly, emulsion is made；
(4) it when the temperature of the emulsion is down to 50 DEG C -55 DEG C, is added one or more in preservative, essence, pigment
Mixture stirs evenly；When temperature is down to 35 DEG C -45 DEG C, sardine small-molecular peptides are added, stirs evenly, is cooled to cream.
Preferably, step (3) includes that A phases are slowly added drop-wise in B phases, in the item that rotating speed is 8000-10000r/min
Under part, emulsifying 40 seconds is carried out, emulsion is made.
The invention has the advantages that and advantageous effects：
1, sardine small-molecular peptides skin cream of the invention has good antioxygenic property, and the clearance rate of hydroxy radical is most
A height of 81.82%, the clearance rate of ultra-oxygen anion free radical is up to 64.38%；
2, moisturizing rate can under the conditions of high humility (relative humidity 81%) for sardine small-molecular peptides skin cream of the invention
Reach 88.85%, moisturizing rate can reach 84.68% under the conditions of low humidity (relative humidity 43%), illustrate that the present invention has
Moistening effect well；
3, sardine small-molecular peptides skin cream stability of the invention is good, and color and luster is pure white, texture uniform and smooth；
4, preparation method provided by the present invention is simple for process, the good moisturizing of prepared skin cream and anti-oxidant work(
Can and have the advantages of good stability, texture uniform and smooth.
Description of the drawings
Fig. 1 is the performance of keeping humidity of 1-6 of the embodiment of the present invention and comparative example 1 under the conditions of high humility (relative humidity 81%)
Test result figure；
Fig. 2 is the performance of keeping humidity of 1-6 of the embodiment of the present invention and comparative example 1 under the conditions of low humidity (relative humidity 43%)
Test result figure.
Specific implementation mode
Technical scheme of the present invention is described further with reference to embodiment and comparative example and effete test embodiment：
Various reagents used in following embodiment are commercial goods, are that can buy to obtain by commercial sources.Its
In, sardine small-molecular peptides are purchased from Chinese Academy of Science Nanhai Ocean Research Institute.
Embodiment 1：
A kind of sardine small-molecular peptides skin cream, by weight percentage, including component：
Sardine small-molecular peptides 0.4%；
Oil phase：Cetostearyl alcohol 7%, White Mineral Oil 10%, silicone oil 1%, beeswax 0.7%, olive oil 3%；；
Water phase：Water 61.7%, glycerine 5%, propylene glycol 5%；
Emulsifier：Sorbitan monostearate 1.5%, Tween-60 1.5%, monoglyceride 1%；Lauryl sodium sulfate
0.5%, xanthans 0.5%；
Auxiliary agent：PE9010 1.2%.
Above-mentioned sardine small-molecular peptides skin cream includes following preparation method：
(1) oil phase and the emulsifier in addition to lauryl sodium sulfate and xanthans are mixed, the item for being 80 DEG C in temperature
It under part, is evenly stirred until and is completely dissolved, A phases are made；
(2) water phase and xanthans are mixed, under conditions of temperature is 80 DEG C, is evenly stirred until after being completely dissolved, reduces
Lauryl sodium sulfate is added in mixing speed, and B phases are made；
(3) A phases are slowly added drop-wise in B phases, under conditions of rotating speed is 9200r/min, carry out emulsifying 40 seconds, system
Obtain emulsion；
(4) when the temperature of the emulsion is down to 50 DEG C -55 DEG C, PE9010 is added, stirs evenly；Wait for that temperature is down to 40 DEG C
When, sardine small-molecular peptides are added, stirs evenly, is cooled to cream.
Embodiment 2：
A kind of sardine small-molecular peptides skin cream, by weight percentage, including component：
Sardine small-molecular peptides 0.5%；
Oil phase：Cetostearyl alcohol 7%, White Mineral Oil 10%, silicone oil 1%, beeswax 0.7%, olive oil 3%；；
Water phase：Water 61.6%, glycerine 5%, propylene glycol 5%；
Emulsifier：Sorbitan monostearate 1.5%, Tween-60 1.5%, monoglyceride 1%；Lauryl sodium sulfate
0.5%, xanthans 0.5%；
Auxiliary agent：PE9010 1.2%.
The preparation method is the same as that of Example 1 for above-mentioned sardine small-molecular peptides skin cream in the present embodiment.
Embodiment 3：
A kind of sardine small-molecular peptides skin cream, by weight percentage, including component：
Sardine small-molecular peptides 0.6%；
Oil phase：Cetostearyl alcohol 7%, White Mineral Oil 10%, silicone oil 1%, beeswax 0.7%, olive oil 3%；；
Water phase：Water 61.5%, glycerine 5%, propylene glycol 5%；
Emulsifier：Sorbitan monostearate 1.5%, Tween-60 1.5%, monoglyceride 1%；Lauryl sodium sulfate
0.5%, xanthans 0.5%；
Auxiliary agent：PE9010 1.2%.
The preparation method is the same as that of Example 1 for above-mentioned sardine small-molecular peptides skin cream in the present embodiment.
Embodiment 4：
A kind of sardine small-molecular peptides skin cream, by weight percentage, including component：
Sardine small-molecular peptides 0.7%；
Oil phase：Cetostearyl alcohol 7%, White Mineral Oil 10%, silicone oil 1%, beeswax 0.7%, olive oil 3%；；
Water phase：Water 61.4%, glycerine 5%, propylene glycol 5%；
Emulsifier：Sorbitan monostearate 1.5%, Tween-60 1.5%, monoglyceride 1%；Lauryl sodium sulfate
0.5%, xanthans 0.5%；
Auxiliary agent：PE9010 1.2%.
The preparation method is the same as that of Example 1 for above-mentioned sardine small-molecular peptides skin cream in the present embodiment.
Embodiment 5：
A kind of sardine small-molecular peptides skin cream, by weight percentage, including component：
Sardine small-molecular peptides 1%；
Oil phase：Cetostearyl alcohol 7%, White Mineral Oil 10%, silicone oil 1%, beeswax 0.7%, olive oil 3%；；
Water phase：Water 61.1%, glycerine 5%, propylene glycol 5%；
Emulsifier：Sorbitan monostearate 1.5%, Tween-60 1.5%, monoglyceride 1%；Lauryl sodium sulfate
0.5%, xanthans 0.5%；
Auxiliary agent：PE9010 1.2%.
The preparation method is the same as that of Example 1 for above-mentioned sardine small-molecular peptides skin cream in the present embodiment.
Embodiment 6：
A kind of sardine small-molecular peptides skin cream, by weight percentage, including component：
Sardine small-molecular peptides 2%；
Oil phase：Cetostearyl alcohol 7%, White Mineral Oil 10%, silicone oil 1%, beeswax 0.7%, olive oil 3%；；
Water phase：Water 60.1%, glycerine 5%, propylene glycol 5%；
Emulsifier：Sorbitan monostearate 1.5%, Tween-60 1.5%, monoglyceride 1%；Lauryl sodium sulfate
0.5%, xanthans 0.5%；
Auxiliary agent：PE9010 1.2%.
The preparation method is the same as that of Example 1 for above-mentioned sardine small-molecular peptides skin cream in the present embodiment.
Comparative example 1：
A kind of skin cream, by weight percentage, including component：
Oil phase：Cetostearyl alcohol 7%, White Mineral Oil 10%, silicone oil 1%, beeswax 0.7%, olive oil 3%；；
Water phase：Water 62.1%, glycerine 5%, propylene glycol 5%；
Emulsifier：Sorbitan monostearate 1.5%, Tween-60 1.5%, monoglyceride 1%；Lauryl sodium sulfate
0.5%, xanthans 0.5%；
Auxiliary agent：PE9010 1.2%.
Above-mentioned skin cream includes following preparation method：
(1) oil phase and the emulsifier in addition to lauryl sodium sulfate and xanthans are mixed, the item for being 80 DEG C in temperature
It under part, is evenly stirred until and is completely dissolved, A phases are made；
(2) water phase and xanthans are mixed, under conditions of temperature is 80 DEG C, is evenly stirred until after being completely dissolved, reduces
Lauryl sodium sulfate is added in mixing speed, and B phases are made；
(3) A phases are slowly added drop-wise in B phases, under conditions of rotating speed is 9200r/min, carry out emulsifying 40 seconds, system
Obtain emulsion；
(4) when the temperature of the emulsion is down to 50 DEG C -55 DEG C, PE9010 is added, stirs evenly, is cooled to cream.
Effete test embodiment 1
Antioxygenic property：Measure the inhibiting rate of hydroxy radical and ultra-oxygen anion free radical
Test method：
The measurement of scavenging hydroxyl (OH) ability：With hydroxy radical test kit (Hydroxyl Free
Radical assay kit) test, the specification of Bioengineering Research Institute is built up according to Nanjing.
Superoxide anion resisitance free radical (O2 -) ability measurement：With inhibition and generation ultra-oxygen anion free radical testing cassete
(Inhibition and produce superoxide anion assay kit) is tested, and bioengineering is built up according to Nanjing
The specification of research institute.
Test result is shown in Table 1.
The antioxygenic property result of 1 sardine small-molecular peptides skin cream of table
As it can be seen from table 1 the Scavenging action to hydroxyl free radical and super oxygen of the sardine small-molecular peptides skin cream of embodiment 1-6 are cloudy
Ion radical clearance rate is higher than the skin cream of comparative example 1, and the clearance rate of hydroxy radical is up to 81.82%, and super oxygen is cloudy
The clearance rate of ion radical is up to 64.38%.It can illustrate, sardine small-molecular peptides skin cream of the invention has good
Antioxygenic property.
Effete test embodiment 2
Performance of keeping humidity
Test method：Under 20 DEG C of isoperibols, saturated aqueous sodium carbonate maintenance relative humidity is placed in drier
(RH) it is 43%, it is 81% to place saturated ammonium sulfate aqueous solution and maintain relative humidity (RH), accurately weighs 1.0g embodiments respectively
The skin cream prepared by sardine small-molecular peptides skin cream and comparative example 1 prepared by 1-6 is scattered in the surface plate of diameter 6cm
In, then surface plate is respectively put into the drier of relative humidity 43% and relative humidity 81%, per accurate every other hour in 10h
Weigh each sample mass, for 24 hours after accurately weigh each sample mass again, by placing the of poor quality of front and back sample, find out sample dehydration
Measure Q.Test result is shown in Fig. 1-2.
Wherein, Q=mi-mo
M in formulaiIt is the quality of i-th hour sample, m0For the original quality of sample to be tested.
From Fig. 1,2 as can be seen that sardine small-molecular peptides skin cream moistening effect and sardine small-molecular peptides content simultaneously
There is no direct relationship.Either high humility (relative humidity 81%) or the condition of low humidity (relative humidity 43%)
Under, the skin cream dehydration prepared by sardine small-molecular peptides skin cream and comparative example 1 prepared by embodiment 1-6 is all relatively more slow
Slowly；After 8h, under conditions of relative humidity (RH)=43% and relative humidity (RH)=81%, the sand prepared by embodiment 1-6
The percentage of water loss of skin cream prepared by fourth fish small-molecular peptides skin cream and comparative example 1 is less than 15.22%.Illustrate Samples EXAMPLE
The skin cream prepared by sardine small-molecular peptides skin cream and comparative example 1 prepared by 1-6 has good performance of keeping humidity.By scheming
1 Fig. 2 is it can also be seen that the sardine small-molecular peptides skin cream of embodiment 4,6 has better moistening effect, the husky fourth of embodiment 4
The sardine small-molecular peptides skin cream moistening effect that fish small-molecular peptides content is 0.70% is best.It calculates in for 24 hours, embodiment 4
Effective moisturizing rate of sardine small-molecular peptides skin cream is 10h, in relative humidity (RH)=43%, sardine small-molecular peptides content
All better than other for 0.7% skin cream performance of keeping humidity, RH=43% and 81%, moisturizing rate respectively reaches 88.85% He
84.68%.
Effete test embodiment 3
Estimation of stability
Organoleptic indicator, physical and chemical index experiment are carried out according to People's Republic of China (PRC) professional standard QB/T1857-2004.Test
It the results are shown in Table 2.
Wherein, physical and chemical index experiment is divided into cold tolerance test, heat resistance test, pH tests.
Test method：
Organoleptic indicator tests：Using prepared by ocular estimate Example 1-6 sardine small-molecular peptides skin cream and comparison
Skin cream prepared by example 1 wipes skin visual observations under temperature and non-direct sunlight indoors, the whiteness of main detection sample,
The appearance characteristics such as glossiness.
Cold tolerance is tested：Sardine small-molecular peptides skin cream and the comparative example prepared by the embodiment 1-6 of 10g are taken respectively
Skin cream prepared by 1 covers tightly lid in dry small size measuring cup, is placed on constant temperature in the refrigerator that temperature is -13 DEG C
48h takes out sample, restores to room temperature, whether there is or not laminations for observation.
Heat resistance is tested：Sardine small-molecular peptides skin cream and the comparative example prepared by the embodiment 1-6 of 10g are taken respectively
Skin cream prepared by 1 covers tightly lid in dry small size measuring cup, is placed on constant temperature in the drying box that temperature is 48 DEG C
48h takes out sample, restores to room temperature, whether there is or not laminations for observation.
PH is tested：Respectively by the sardine small-molecular peptides skin cream and the profit for preparing of comparative example 1 prepared by 2g embodiments 1-6
Skin frost adds 18g distilled water with 1:9 ratio, which accurately weighs, to be put into 50ml beakers, and stirring to sample is all dissolved, with having corrected
Good pH electrode is put into sample solution, and reading is read after stablizing, and each sample testing three times, takes its average value conduct
The pH value of this sample.
The estimation of stability of 2 sardine small-molecular peptides skin cream of table
From table 2 it can be seen that the sardine small-molecular peptides skin cream prepared by embodiment 1-6 all has preferable stability
And the texture of uniform and smooth.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, in the range of still falling within technical solution of the present invention.
Claims (10)
1. a kind of sardine small-molecular peptides skin cream, which is characterized in that by weight percentage, the skin cream mainly include with
Lower component：Sardine small-molecular peptides 0.4-2%, oil phase 15-30%, water phase 60-80% and emulsifier 3-5%.
2. sardine small-molecular peptides skin cream according to claim 1, it is characterised in that：The sardine small-molecular peptides
Molecular weight is less equal than 3000 dalton.
3. sardine small-molecular peptides skin cream according to claim 1, it is characterised in that：The oil phase is selected from 16
In alcohol, White Mineral Oil, silicone oil, beeswax, olive oil, shea butter, vaseline, caprylic/capric triglyceride it is any one or two kinds of with
On mixing.
4. sardine small-molecular peptides skin cream according to claim 3, it is characterised in that：The oil phase is by 16
Alcohol, White Mineral Oil, silicone oil, beeswax and olive oil composition.
5. the sardine small-molecular peptides skin cream stated according to claim 1, it is characterised in that：The water phase is selected from water, glycerine, third
Any one or more mixing in glycol, 1,3- succinic acid, allantoin, sorbic acid.
6. sardine small-molecular peptides skin cream according to claim 5, it is characterised in that：The water phase is by water, glycerine, third
Glycol forms.
7. sardine small-molecular peptides skin cream according to claim 1, it is characterised in that：The emulsifier is selected from poly- second two
Alcohol, sorbitan monostearate, Tween-60, monoglyceride, alkyl glycosides, potassium alkyl phosphate, aliphatic alcohol polyethenoxy
Any one or more mixing in ether, lauryl sodium sulfate, xanthans.
8. sardine small-molecular peptides skin cream according to claim 7, it is characterised in that：The emulsifier is by sorbitol anhydride
Monostearate, Tween-60, monoglyceride, lauryl sodium sulfate, xanthans composition.
9. sardine small-molecular peptides skin cream according to claim 1, which is characterized in that by weight percentage, described
Skin cream also includes following components：Auxiliary agent 0.1-5%；The auxiliary agent is one or more mixing in preservative, essence, pigment
Object.
10. a kind of preparation method of sardine small-molecular peptides skin cream as described in any one of claims 1-9, feature exist
In this approach includes the following steps：
(1) oil phase and the emulsifier in addition to lauryl sodium sulfate and xanthans are mixed, the condition for being 75-80 DEG C in temperature
Under, it is evenly stirred until and is completely dissolved, A phases are made；
(2) water phase and xanthans are mixed, under conditions of temperature is 75-80 DEG C, is evenly stirred until after being completely dissolved, reduction is stirred
Speed is mixed, lauryl sodium sulfate is added, B phases are made；
(3) A phases are slowly added drop-wise in B phases, are stirred evenly, emulsion is made；
(4) when the temperature of the emulsion is down to 50 DEG C -55 DEG C, one or more mixing in preservative, essence, pigment are added
Object stirs evenly；When temperature is down to 35 DEG C -45 DEG C, sardine small-molecular peptides are added, stirs evenly, is cooled to cream.
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| Publication number | Priority date | Publication date | Assignee | Title |
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Application publication date: 20180810 |