CN107308022A - A kind of preparation method of cod collagen peptide emulsion - Google Patents
A kind of preparation method of cod collagen peptide emulsion Download PDFInfo
- Publication number
- CN107308022A CN107308022A CN201710451345.2A CN201710451345A CN107308022A CN 107308022 A CN107308022 A CN 107308022A CN 201710451345 A CN201710451345 A CN 201710451345A CN 107308022 A CN107308022 A CN 107308022A
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- China
- Prior art keywords
- collagen peptide
- added
- preparation
- cod collagen
- cod
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
A kind of preparation method of cod collagen peptide emulsion, belongs to emulsion preparing technical field, the present invention includes：Prepared by cod collagen peptide, prepared by aqueous phase liquid, and oil phase feed liquid is prepared and emulsification.Cod collagen peptide emulsion produced by the present invention is added without chemistry, and with excellent moisturizing whitening and skin-protecting effect, long-term use can make skin smooth bright, and suitable for easy allergic person.
Description
Technical field
The present invention relates to a kind of facial treatment milk and preparation method thereof, and in particular to a kind of preparation of cod collagen peptide emulsion
Method.
Background technology
Emulsion is that the active ingredients such as moisturizing, whitening and anti-aging in the most important step of basic skin care, emulsion can be more preferable
By percutaneous absorption, so, possess one bottle of good emulsion be it is very important, in the market occur emulsion, majority all contain
There are a large amount of chemical substances, it is well known that many chemical substances are to have certain toxicity to the mankind, and long-term use can to skin
Certain side effect, preferable skin effect of arriving can be produced.If selection is improper to will result in immeasurable loss, mesh
Before, many emulsions are when making on the market, the problem of selection of chemical substance has very big, and skin effect is not notable, needs
Further improve.
The content of the invention
The present invention provide it is a kind of it is natural it is no added, be conducive to skin-whitening to be humidified, make a kind of skin care that skin smooth is bright
Emulsion.
The present invention uses following technical scheme：
A kind of preparation method of cod collagen peptide emulsion, comprises the following steps：
Step one：Cod collagen is taken, the collagen aqueous solution that substrate mass concentration is 1% is configured to；
Step 2：It is 8.0 to adjust collagen aqueous solution pH value, the alkali protease of mass percent 1% is added, 50
DEG C water-bath in carry out enzyme digestion reaction 60min, obtain enzymolysis liquid, boiling water goes out enzyme 10min immediately, is cooled to room temperature with 8000r/
Min centrifugal treating 15min, take supernatant, and rotary evaporation is concentrated to give cod collagen peptide extract；
Step 3：Deionized water is weighed, 60 DEG C are heated to, the carboxylic benzyl for accounting for ionized water mass percent 1% is added,
Whole dissolvings are treated, the Sodium Hyaluronate for accounting for ionized water mass percent 2% is added, is well mixed and is cooled to room temperature, then
The glycerine and 4% 1,3-BDO for accounting for ionized water mass percent 8% are added, is well mixed, is added and account for ionized water
The cod collagen peptide extract of mass percent 8% and 1% L-vitamin C mixing are hooked, and obtain aqueous phase liquid；
Step 4：Grape-kernel oil is taken, and adds vitamin E and emulsifying agent, wherein grape-kernel oil and vitamin E, emulsifying agent
Mass ratio be 100：1：3, it is well mixed to obtain oil phase feed liquid；
Step 5：Step 3 is made into aqueous phase liquid to be slowly added into the oil phase feed liquid of step 4 preparation, described water
Phase feed liquid is 85 with oil phase feed liquid mass ratio:15, mixed liquor is well mixed to obtain, percentage by weight 3% is added into mixed liquor
Sodium carboxymethylcellulose, then mixed liquor addition vacuum emulsifying machine Inner is emulsified, produce cod collagen peptide emulsion.
It is preferred that, the emulsifying agent in described step four is polyvinyl alcohol.
It is preferred that, the essential oil that percentage by weight 3% is added into oil phase feed liquid is also included in described step four.
It is preferred that, described essential oil is Rosa Damascana.
The beneficial effects of the present invention are：
1) cod collagen peptide collagen peptide is a kind of material to skin with Pleiotropic Protections, not only in replenishing water and preserving moisture
Aspect plays excellent effect, moreover it is possible to resists the damage in the structure function that aging on skin is caused, may also suppress tyrosine
The activity of enzyme and the synthesis of melanin, can be as the whitening additive in cosmetics, by suppressing the activity of tyrosinase, suppressing
The synthesis of melanin, direct skin whitening.
2) oil phase uses natural grape-kernel oil, and grape-kernel oil serves a dual purpose to skin, and on the one hand it can promote collagen
Albumen forms appropriately crosslinked, on the other hand, and it can prevent skin " excessively crosslinking " as a kind of effective free radical scavenger,
So as to also it is prevented that the appearance of wrinkle of skin and vesica, keeps the soft and moist smooth of skin.Grape-kernel oil is also a kind of efficient
Beauty and skin care health-care good product that is anti-oxidant and removing free radical, and it is easy to skin connective tissue absorption, protection skin can be assisted to exempt from
By ultraviolet damage, nourishes rough skin reduces skin disease and wrinkle, or even eliminate scar.Grape-kernel oil is to be found so far
One of most potent free radical scavenger, main extract-OPC (OPC) of grape pip has the work(of whitening spot-removing
Effect：It is 50 times of vitamin e because OPC has superpower oxidation resistance, is 20 times of Vitamin C, energy delaying aging,
Prevention of arterial is hardened, and also has the title of skin vitamin, with fat-soluble and water miscible speciality, is made with superpower whitening spot-removing
With.The various spots such as skin splash, chloasma, butterfly macules can be eliminated.
3) hydrosol, emulsifying agent, thickening are mainly used as in cosmetics as emulsifying agent using sodium carboxymethylcellulose
Agent, can give full play to skin care effect together by extract effective integration.
4) emulsion produced by the present invention is added without chemistry, and with excellent moisturizing, whitening and skin-protecting effect, long-term use can
So that skin smooth is bright, and suitable for easy allergic person.
Embodiment
Below with reference to specific embodiment, the present invention is described further.
Embodiment 1
A kind of preparation method of cod collagen peptide emulsion, comprises the following steps：
Step one：Cod collagen is taken, the collagen aqueous solution that substrate mass concentration is 1% is configured to；
Step 2：It is 8.0 to adjust collagen aqueous solution pH value, the alkali protease of mass percent 1% is added, 50
DEG C water-bath in carry out enzyme digestion reaction 60min, obtain enzymolysis liquid, boiling water goes out enzyme 10min immediately, is cooled to room temperature with 8000r/
Min centrifugal treating 15min, take supernatant, and rotary evaporation is concentrated to give cod collagen peptide extract；
Step 3：Deionized water is weighed, 60 DEG C are heated to, the carboxylic benzyl for accounting for ionized water mass percent 1% is added,
Whole dissolvings are treated, the Sodium Hyaluronate for accounting for ionized water mass percent 2% is added, is well mixed and is cooled to room temperature, then
The glycerine and 4% 1,3-BDO for accounting for ionized water mass percent 8% are added, is well mixed, is added and account for ionized water
The cod collagen peptide extract of mass percent 8% and 1% L-vitamin C mixing are hooked, and obtain aqueous phase liquid；
Step 4：Grape-kernel oil is taken, and adds vitamin E and emulsifying agent, wherein grape-kernel oil and vitamin E, emulsifying agent
Mass ratio be 100：1：3, it is well mixed to obtain oil phase feed liquid；
Step 5：Step 3 is made into aqueous phase liquid to be slowly added into the oil phase feed liquid of step 4 preparation, described water
Phase feed liquid is 85 with oil phase feed liquid mass ratio:15, mixed liquor is well mixed to obtain, percentage by weight 3% is added into mixed liquor
Sodium carboxymethylcellulose, then mixed liquor addition vacuum emulsifying machine Inner is emulsified, produce cod collagen peptide emulsion.
Emulsifying agent in described step four is polyvinyl alcohol.
Also include the essential oil that percentage by weight 3% is added into oil phase feed liquid in described step four, described essential oil is
Rosa Damascana.
Carried out a test from 120 people, contrast existing facial treatment milk, be divided into control group 1, control group 2 and reality
3 (embodiments) of group are tested, every group of 40 people record moisturizing whitening effect, skin effect and the skin mistake of testing crew skin respectively
Quick number, experiment effect following three standard：
It is effective：Moisturizing whitening effect is obvious, skin smooth is glossy.
Effectively：Moisturizing whitening effect is more apparent, skin is more smooth tiny cutin, and glossiness is general.
It is invalid：Obvious, pachylosis is not obscure for moisturizing whitening effect.
As a result it see the table below.
In addition, the personnel of experimental group are after use, through observation after a while, there are 3 people skin mistake occur in control group 1
Quick, it is allergic that control group 2 has 5 people to occur, and it is allergic that experimental group has 1 people to occur.
As can be seen here, the present invention is one group maximally effective to skin nursing, compared with control group, skin care milk of the invention
Liquid has significant effect to skin moisturizing, whitening, smooth etc., while side effect is minimum in three groups.
Claims (4)
1. a kind of preparation method of cod collagen peptide emulsion, it is characterised in that comprise the following steps：
Step one：Cod collagen is taken, the collagen aqueous solution that substrate mass concentration is 1% is configured to；
Step 2：It is 8.0 to adjust collagen aqueous solution pH value, the alkali protease of mass percent 1% is added, at 50 DEG C
Enzyme digestion reaction 60min is carried out in water-bath, enzymolysis liquid is obtained, boiling water goes out enzyme 10min immediately, be cooled to room temperature with 8000r/min from
The heart handles 15min, takes supernatant, rotary evaporation is concentrated to give cod collagen peptide extract；
Step 3：Deionized water is weighed, 60 DEG C are heated to, the carboxylic benzyl for accounting for ionized water mass percent 1% is added, treats complete
Portion dissolves, and adds the Sodium Hyaluronate for accounting for ionized water mass percent 2%, is well mixed and is cooled to room temperature, adds
The glycerine of ionized water mass percent 8% and 4% 1,3-BDO are accounted for, is well mixed, is added and account for ion water quality
The cod collagen peptide extract of percentage 8% and 1% L-vitamin C mixing are hooked, and obtain aqueous phase liquid；
Step 4：Grape-kernel oil is taken, and adds vitamin E and emulsifying agent, wherein grape-kernel oil and vitamin E, the matter of emulsifying agent
Amount is than being 100：1：3, it is well mixed to obtain oil phase feed liquid；
Step 5：Step 3 is made into aqueous phase liquid to be slowly added into the oil phase feed liquid of step 4 preparation, described aqueous phase material
Liquid is 85 with oil phase feed liquid mass ratio:15, mixed liquor is well mixed to obtain, the carboxylic first of percentage by weight 3% is added into mixed liquor
Base sodium cellulosate, then mixed liquor addition vacuum emulsifying machine Inner is emulsified, produce cod collagen peptide emulsion.
2. a kind of preparation method of cod collagen peptide emulsion according to claim 1, it is characterised in that：Described step
Emulsifying agent in four is polyvinyl alcohol.
3. a kind of preparation method of cod collagen peptide emulsion according to claim 1, it is characterised in that：Described step
Also include the essential oil that percentage by weight 3% is added into oil phase feed liquid in four.
4. a kind of preparation method of cod collagen peptide emulsion according to claim 3, it is characterised in that：Described essential oil
For Rosa Damascana.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710451345.2A CN107308022A (en) | 2017-06-15 | 2017-06-15 | A kind of preparation method of cod collagen peptide emulsion |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710451345.2A CN107308022A (en) | 2017-06-15 | 2017-06-15 | A kind of preparation method of cod collagen peptide emulsion |
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| Publication Number | Publication Date |
|---|---|
| CN107308022A true CN107308022A (en) | 2017-11-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710451345.2A Pending CN107308022A (en) | 2017-06-15 | 2017-06-15 | A kind of preparation method of cod collagen peptide emulsion |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108379109A (en) * | 2018-04-19 | 2018-08-10 | 佛山科学技术学院 | Sardine small-molecular peptides skin cream and preparation method thereof |
| CN108653089A (en) * | 2018-07-02 | 2018-10-16 | 芜湖扬展新材料科技服务有限公司 | A kind of preparation method of anti-aging anti-wrinkle lotion |
| CN110755293A (en) * | 2019-12-16 | 2020-02-07 | 卢婷婷 | Preparation method of antioxidant and anti-wrinkling composite moisturizing cream |
| CN113116744A (en) * | 2021-03-19 | 2021-07-16 | 徐晓芬 | Active peptide skin care product capable of improving skin pigmentation and preparation process thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102302417A (en) * | 2011-09-13 | 2012-01-04 | 佛山市安安美容保健品有限公司 | Comprehensive-effect sunscreen lotion containing oceanic biological active substances |
| CN102851341A (en) * | 2011-07-02 | 2013-01-02 | 山东省烟台农业学校 | Process for preparing collagen polypeptides through hydrolyzing codfish skins by double-enzyme composite method |
-
2017
- 2017-06-15 CN CN201710451345.2A patent/CN107308022A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102851341A (en) * | 2011-07-02 | 2013-01-02 | 山东省烟台农业学校 | Process for preparing collagen polypeptides through hydrolyzing codfish skins by double-enzyme composite method |
| CN102302417A (en) * | 2011-09-13 | 2012-01-04 | 佛山市安安美容保健品有限公司 | Comprehensive-effect sunscreen lotion containing oceanic biological active substances |
Non-Patent Citations (1)
| Title |
|---|
| 李幸: "鳕鱼皮胶原肽保湿护肤效果的研究", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108379109A (en) * | 2018-04-19 | 2018-08-10 | 佛山科学技术学院 | Sardine small-molecular peptides skin cream and preparation method thereof |
| CN108653089A (en) * | 2018-07-02 | 2018-10-16 | 芜湖扬展新材料科技服务有限公司 | A kind of preparation method of anti-aging anti-wrinkle lotion |
| CN110755293A (en) * | 2019-12-16 | 2020-02-07 | 卢婷婷 | Preparation method of antioxidant and anti-wrinkling composite moisturizing cream |
| CN113116744A (en) * | 2021-03-19 | 2021-07-16 | 徐晓芬 | Active peptide skin care product capable of improving skin pigmentation and preparation process thereof |
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Application publication date: 20171103 |