CN110755293A - Preparation method of antioxidant and anti-wrinkling composite moisturizing cream - Google Patents
Preparation method of antioxidant and anti-wrinkling composite moisturizing cream Download PDFInfo
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- CN110755293A CN110755293A CN201911291215.2A CN201911291215A CN110755293A CN 110755293 A CN110755293 A CN 110755293A CN 201911291215 A CN201911291215 A CN 201911291215A CN 110755293 A CN110755293 A CN 110755293A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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Abstract
The invention relates to a preparation method of an antioxidant and anti-wrinkling composite moisturizing cream, and belongs to the technical field of cosmetics. The cod skin collagen peptide can supplement nutrients required for skin, enhance the activity of collagen in the skin, maintain the integrity of stratum corneum moisture and a fiber structure, improve the skin cell environment, promote the metabolism and circulation of skin tissues, and achieve the purposes of moistening the skin, increasing the elasticity and delaying the aging.
Description
Technical Field
The invention relates to a preparation method of an antioxidant and anti-wrinkling composite moisturizing cream, and belongs to the technical field of cosmetics.
Background
The skin care cosmetic is used for keeping proper moisture in skin, especially stratum corneum of the outermost layer of skin, and is characterized in that the skin care cosmetic not only can keep the moisture balance in the skin, but also can supplement important oily components and hydrophilic moisture retention components, and can be used as a carrier of active components and medicaments to be easily absorbed by the skin, so that the aim of conditioning the skin is fulfilled, and the skin is moistened and healthy. Moisturization is a basic function of personal care products, and particularly, skin care products are particularly important because the moisture content of the skin can improve the elasticity and smoothness of the skin, thereby achieving the purpose of preventing aging. However, the skin care cosmetics are obviously insufficient in the aspect of oxidation resistance, so that considerable economic benefits can be brought by developing a moisturizing skin care series product with good oxidation resistance.
Disclosure of Invention
The technical problems to be solved by the invention are as follows: the invention provides a preparation method of an antioxidant crease-resistant compound moisturizing cream, aiming at the problem that the prior moisturizing cosmetics are insufficient in antioxidant performance.
In order to solve the technical problems, the invention adopts the technical scheme that:
(1) respectively weighing 20-40 parts by weight of cod skin collagen peptide solution, 10-20 parts by weight of glycerol, 10-20 parts by weight of polyethylene glycol, 2-4 parts by weight of dimethyl polysiloxane, 4-8 parts by weight of vaseline, 2-4 parts by weight of shea butter, 8-16 parts by weight of cocoa butter, 2-4 parts by weight of glucose, 1-2 parts by weight of hydroxyethyl urea, 0.4-0.8 part by weight of glyceryl stearate, 0.2-0.4 part by weight of polyoxyethylene lauryl ether and 40-80 parts by weight of deionized water;
(2) adding glucose, hydroxyethyl urea, glyceryl stearate and polyoxyethylene lauryl ether into deionized water, and stirring at the normal temperature at the rotating speed of 200-300 r/min for 20-30 min to obtain an emulsifier mixed solution;
(3) adding the emulsifier mixed solution, glycerol, polyethylene glycol, dimethyl polysiloxane, vaseline, shea butter and cocoa butter into the cod skin collagen peptide solution, placing the mixture into a high-shear emulsifying machine, stirring the mixture for 1 to 2 hours at a rotating speed of 12000 to 16000r/min under the water bath condition of 40 to 50 ℃, placing the mixture into an ultrasonic dispersion machine, performing ultrasonic treatment for 20 to 30 minutes at normal temperature, and sealing and storing the mixture to obtain the antioxidant crease-resistant composite moisturizing cream.
And (4) the power of ultrasonic treatment in the step (3) is 500-600W.
The specific preparation steps of the cod skin collagen peptide solution are as follows:
(1) respectively weighing 10-20 parts by weight of cod skin collagen, 0.1-0.2 part by weight of alkaline protease and 100-200 parts by weight of deionized water;
(2) adding cod skin collagen into deionized water, stirring at the normal temperature for 10-20 min at a speed of 180-200 r/min, and adjusting the pH to 7.8-8.2 to obtain a collagen mixed solution;
(3) adding alkaline protease into the collagen mixed solution, and stirring and performing enzymolysis for 40-60 min at the rotating speed of 120-160 r/min under the water bath condition of 45-55 ℃ to obtain an enzymolysis solution;
(4) and (3) putting the enzymolysis liquid into boiling water, preserving heat and inactivating for 10-12 min, cooling at normal temperature, putting the solution into a centrifugal machine, centrifugally separating for 10-15 min at the rotating speed of 6000-8000 r/min, and taking supernatant to obtain the cod skin collagen peptide solution. And (3) adopting a sodium carbonate solution with the mass fraction of 1% for pH adjustment in the step (2).
The specific preparation steps of the cod skin collagen are as follows:
(1) respectively weighing 20-30 parts by weight of defatted cod skin, 200-300 parts by weight of 10% sodium hydroxide solution and 200-300 parts by weight of 10% acetic acid solution;
(2) adding the degreased cod skin into a sodium hydroxide solution with the mass fraction of 10%, soaking for 40-60 min at the temperature of 2-4 ℃, and filtering to obtain a filter cake;
(3) washing the filter cake with distilled water for 3-5 times, draining, adding 10% by mass of sodium hydroxide solution for homogenizing, stirring at the temperature of 2-4 ℃ at the rotating speed of 200-300 r/min for 30-40 min, and extracting for 1-3 days to obtain cod skin mixed slurry;
(4) and (3) placing the cod skin mixed slurry in a centrifuge, centrifugally separating at the temperature of 2-4 ℃ at the rotating speed of 3000-4000 r/min for 30-40 min, taking supernatant, and freeze-drying to obtain cod skin collagen.
The specific preparation steps of the degreased cod skin are as follows:
(1) respectively weighing 10-20 parts of cod skin, 10-20 parts of n-butanol and 100-200 parts of deionized water in parts by weight;
(2) adding n-butyl alcohol into deionized water, and stirring at the normal temperature at the rotating speed of 100-140 r/min for 10-12 min to obtain an n-butyl alcohol solution;
(3) washing the cod skin with tap water for 3-5 times, airing at normal temperature, placing in a n-butyl alcohol solution, standing and soaking for 20-24 hours under a refrigeration condition of 2-4 ℃, and filtering to obtain a filter cake;
(4) washing the filter cake with tap water for 3-5 times, and refrigerating and drying for 1-3 days at 0-4 ℃ to obtain the degreased cod skin.
Compared with other methods, the method has the beneficial technical effects that:
the invention takes cod skin collagen peptide as raw material to prepare an antioxidant crease-resistant composite moisturizing cream, the collagen peptide is an enzymolysis product of collagen, contains all amino acids of the collagen, has good performances of absorptivity, solubility, water retention and moisture retention, etc., the collagen peptide is polypeptide which is formed by collagen through enzymolysis by protease, can effectively reduce antigenicity, greatly enhances the solubility of the collagen peptide, can be dissolved in cold water, has high nutrition, can supplement required nutrients for skin, provides seventeen amino acids beneficial to human body, enhances the collagen activity in skin, maintains the integrity of stratum corneum moisture and fiber structure, improves skin cell environment, promotes the metabolism and circulation of skin tissues, achieves the purposes of moisturizing skin, increasing elasticity and delaying aging, and the moisturizing cream added with the cod skin collagen peptide has excellent repairing performance, collagen and surrounding tissues have good affinity and unique repair function, can form normal connective tissues with self tissues to fill and repair aged and damaged skin, a large number of hydrophilic groups such as hydroxyl, carboxyl and the like are exposed in polypeptide molecules formed after collagen is hydrolyzed, and in addition, the collagen peptide also contains abundant moisturizing factors such as serine, glycine, aspartic acid and the like, so that the collagen peptide has good moisture retention property. The collagen peptide with small molecular weight can quickly enter the epidermal layer of the skin, is combined with water molecules to form a net structure, locks moisture and is absorbed by the skin, plays a role of natural moisturizing factors, enables the skin to be moist, has good affinity with the skin, can permeate into the epidermal layer of the skin, is fully absorbed by the skin, is filled between skin substrates, and can form an extremely thin film layer on the surface of the skin, so that the skin is plump, the tension is increased, wrinkles are stretched and the skin is full of elasticity.
Detailed Description
Respectively weighing 10-20 parts of cod skin, 10-20 parts of n-butanol and 100-200 parts of deionized water according to parts by weight, adding n-butanol into deionized water, stirring at the normal temperature at the rotating speed of 100-140 r/min for 10-12 min to obtain an n-butanol solution, washing the cod skin with tap water for 3-5 times, airing at the normal temperature, placing the cod skin into the n-butanol solution, standing and soaking for 20-24 h under the refrigeration condition of 2-4 ℃, filtering to obtain a filter cake, washing the filter cake with tap water for 3-5 times, and performing refrigeration drying at the temperature of 0-4 ℃ for 1-3 days to obtain degreased cod skin;
respectively weighing 20-30 parts by weight of defatted cod skin, 200-300 parts by weight of 10% sodium hydroxide solution and 200-300 parts by weight of 10% acetic acid solution, adding the defatted cod skin into the 10% sodium hydroxide solution, soaking for 40-60 min at the temperature of 2-4 ℃, filtering to obtain a filter cake, washing the filter cake for 3-5 times by using distilled water, draining, adding the filter cake into the 10% sodium hydroxide solution for homogenizing, stirring for 30-40 min at the temperature of 2-4 ℃ at the rotating speed of 200-300 r/min, extracting for 1-3 days to obtain cod skin mixed slurry, placing the cod skin mixed slurry in a centrifuge, centrifuging for 30-40 min at the rotating speed of 3000-4000 r/min at the temperature of 2-4 ℃, taking supernatant, and freeze-drying to obtain cod skin collagen;
respectively weighing 10-20 parts by weight of cod skin collagen, 0.1-0.2 part by weight of alkaline protease and 100-200 parts by weight of deionized water, adding the cod skin collagen into the deionized water, stirring for 10-20 min at 180-200 r/min at normal temperature, dropwise adding 1% by weight of sodium carbonate solution to adjust the pH value to 7.8-8.2 to obtain collagen mixed solution, adding the alkaline protease into the collagen mixed solution, stirring for enzymolysis for 40-60 min at the rotating speed of 120-160 r/min under the water bath condition of 45-55 ℃ to obtain enzymolysis solution, placing the enzymolysis solution in boiling water, preserving heat and inactivating for 10-12 min, cooling at normal temperature, placing in a centrifuge, centrifugally separating for 10-15 min at the rotating speed of 6000-8000 r/min, and taking supernatant to obtain cod skin collagen peptide solution;
respectively weighing 20-40 parts by weight of cod skin collagen peptide solution, 10-20 parts by weight of glycerol, 10-20 parts by weight of polyethylene glycol, 2-4 parts by weight of dimethyl polysiloxane, 4-8 parts by weight of vaseline, 2-4 parts by weight of shea butter, 8-16 parts by weight of cocoa butter, 2-4 parts by weight of glucose, 1-2 parts by weight of hydroxyethyl urea, 0.4-0.8 part by weight of glyceryl stearate, 0.2-0.4 part by weight of polyoxyethylene lauryl ether and 40-80 parts by weight of deionized water, adding glucose, hydroxyethyl urea, glyceryl stearate and polyoxyethylene lauryl ether into the deionized water, stirring at 200-300 r/min at normal temperature for 20-30 min to obtain an emulsifier mixed solution, adding the emulsifier mixed solution, glycerol, polyethylene glycol, dimethyl polysiloxane, vaseline, shea butter and cocoa butter into the cod skin collagen peptide solution, placing the cod skin collagen peptide solution in a high-shear emulsifying machine, stirring at 12000-16000 r/min for 1-2 h under the water bath condition of 40-50 ℃, and then placing the mixture in an ultrasonic dispersion machine, carrying out ultrasonic treatment for 20-30 min at normal temperature with the power of 500-600W, and sealing and storing to obtain the antioxidant crease-resistant compound moisturizing cream.
Example 1
Respectively weighing 10 parts of cod skin, 10 parts of n-butyl alcohol and 100 parts of deionized water according to parts by weight, adding the n-butyl alcohol into the deionized water, stirring at the rotating speed of 100r/min for 10min at normal temperature to obtain n-butyl alcohol solution, washing the cod skin with tap water for 3 times, airing at normal temperature, placing the cod skin into the n-butyl alcohol solution, standing and soaking for 20h under the refrigeration condition of 2 ℃, filtering to obtain a filter cake, washing the filter cake with tap water for 3 times, and performing refrigeration drying at 0 ℃ for 1 day to obtain degreased cod skin;
respectively weighing 20 parts of degreased cod skin, 200 parts of a sodium hydroxide solution with the mass fraction of 10% and 200 parts of an acetic acid solution with the mass fraction of 10%, adding the degreased cod skin into the sodium hydroxide solution with the mass fraction of 10%, soaking for 40min at the temperature of 2 ℃, filtering to obtain a filter cake, washing the filter cake for 3 times by using distilled water, draining, adding the filter cake into the sodium hydroxide solution with the mass fraction of 10% for homogenizing, stirring for 30min at the speed of 200r/min at the temperature of 2 ℃, extracting for 1 day to obtain cod skin mixed slurry, placing the cod skin mixed slurry into a centrifuge, centrifugally separating for 30min at the speed of 3000r/min at the temperature of 2 ℃, taking supernatant, and freeze-drying to obtain cod skin collagen;
respectively weighing 10 parts of cod skin collagen, 0.1 part of alkaline protease and 100 parts of deionized water according to parts by weight, adding the cod skin collagen into the deionized water, stirring for 10min at 180r/min at normal temperature, dropwise adding a sodium carbonate solution with the mass fraction of 1% to adjust the pH to 7.8 to obtain a collagen mixed solution, adding the alkaline protease into the collagen mixed solution, stirring for enzymolysis for 40min at the rotating speed of 120r/min under the water bath condition of 45 ℃ to obtain an enzymolysis solution, placing the enzymolysis solution into boiling water, preserving heat and inactivating for 10min, cooling at normal temperature, placing into a centrifuge, centrifugally separating for 10min at the rotating speed of 6000r/min, and taking a supernatant to obtain a cod skin collagen peptide solution;
respectively weighing 20 parts of cod skin collagen peptide solution, 10 parts of glycerol, 10 parts of polyethylene glycol, 2 parts of dimethyl polysiloxane, 4 parts of vaseline, 2 parts of shea butter, 8 parts of cocoa butter, 2 parts of glucose, 1 part of hydroxyethyl urea, 0.4 part of glyceryl stearate, 0.2 part of polyoxyethylene lauryl ether and 40 parts of deionized water, adding the glucose, the hydroxyethyl urea, the glyceryl stearate and the polyoxyethylene lauryl ether into the deionized water, stirring at the normal temperature of 200r/min for 20min to obtain an emulsifier mixed solution, adding the emulsifier mixed solution, the glycerol, the polyethylene glycol, the dimethyl polysiloxane, the vaseline, the shea butter and the cocoa butter into the cod skin collagen peptide solution, placing the cod skin collagen peptide solution into a high-shear emulsifying machine, stirring at the water bath condition of 40 ℃ at the rotating speed of 12000r/min for 1h, placing the cod skin collagen peptide solution into an ultrasonic dispersing machine, and (3) carrying out ultrasonic treatment at the normal temperature for 20min at the power of 500W, and sealing and storing to obtain the antioxidant crease-resistant composite moisturizing cream.
Example 2
Respectively weighing 15 parts of cod skin, 15 parts of n-butyl alcohol and 150 parts of deionized water according to parts by weight, adding the n-butyl alcohol into the deionized water, stirring at the rotating speed of 120r/min for 11min at normal temperature to obtain n-butyl alcohol solution, washing the cod skin with tap water for 4 times, airing at normal temperature, placing the cod skin into the n-butyl alcohol solution, standing and soaking for 22h under the refrigeration condition of 3 ℃, filtering to obtain a filter cake, washing the filter cake with tap water for 4 times, and refrigerating and drying for 2 days at the temperature of 2 ℃ to obtain degreased cod skin;
respectively weighing 25 parts of degreased cod skin, 250 parts of a sodium hydroxide solution with the mass fraction of 10% and 250 parts of an acetic acid solution with the mass fraction of 10%, adding the degreased cod skin into the sodium hydroxide solution with the mass fraction of 10%, soaking for 50min at the temperature of 3 ℃, filtering to obtain a filter cake, washing the filter cake for 4 times by using distilled water, draining, adding the filter cake into the sodium hydroxide solution with the mass fraction of 10% for homogenizing, stirring for 35min at the speed of 250r/min at the temperature of 3 ℃, extracting for 2 days to obtain cod skin mixed slurry, placing the cod skin mixed slurry into a centrifuge, centrifugally separating for 35min at the speed of 3500r/min at the temperature of 3 ℃, taking supernatant, and freeze-drying to obtain cod skin collagen;
respectively weighing 15 parts of cod skin collagen, 0.15 part of alkaline protease and 150 parts of deionized water according to parts by weight, adding the cod skin collagen into the deionized water, stirring for 15min at the normal temperature at 190r/min, dropwise adding a sodium carbonate solution with the mass fraction of 1% to adjust the pH value to 8.0 to obtain a collagen mixed solution, adding the alkaline protease into the collagen mixed solution, stirring for enzymolysis for 50min at the water bath condition of 50 ℃ at the rotating speed of 140r/min to obtain an enzymolysis solution, placing the enzymolysis solution into boiling water, preserving heat and inactivating for 11min, cooling at the normal temperature, placing the solution into a centrifugal machine, centrifugally separating for 12.5min at the rotating speed of 7000r/min, and taking supernatant to obtain a cod skin collagen peptide solution; respectively weighing 30 parts of cod skin collagen peptide solution, 15 parts of glycerol, 15 parts of polyethylene glycol, 3 parts of dimethyl polysiloxane, 6 parts of vaseline, 3 parts of shea butter, 12 parts of cocoa butter, 3 parts of glucose, 1.5 parts of hydroxyethyl urea, 0.6 part of glyceryl stearate, 0.3 part of polyoxyethylene lauryl ether and 60 parts of deionized water, adding the glucose, the hydroxyethyl urea, the glyceryl stearate and the polyoxyethylene lauryl ether into the deionized water, stirring at the normal temperature at the rotating speed of 250r/min for 25min to obtain an emulsifier mixed solution, adding the emulsifier mixed solution, the glycerol, the polyethylene glycol, the dimethyl polysiloxane, the vaseline, the shea butter and the cocoa butter into the cod skin collagen peptide solution, placing the mixture into a high-shear emulsifying machine, stirring at the rotating speed of 14000r/min for 1.5h under the water bath condition of 45 ℃, placing the mixture into an ultrasonic dispersing machine, and (4) carrying out ultrasonic treatment for 25min at the normal temperature with the power of 5500W, and sealing and storing to obtain the antioxidant crease-resistant compound moisturizing cream.
Example 3
Respectively weighing 20 parts of cod skin, 20 parts of n-butyl alcohol and 200 parts of deionized water according to parts by weight, adding the n-butyl alcohol into the deionized water, stirring at the normal temperature at the rotating speed of 140r/min for 12min to obtain n-butyl alcohol solution, washing the cod skin with tap water for 5 times, airing at normal temperature, placing the cod skin into the n-butyl alcohol solution, standing and soaking for 24h under the refrigeration condition of 4 ℃, filtering to obtain a filter cake, washing the filter cake with tap water for 5 times, and refrigerating and drying for 3 days under the condition of 4 ℃ to obtain degreased cod skin;
respectively weighing 30 parts of degreased cod skin, 300 parts of a sodium hydroxide solution with the mass fraction of 10% and 300 parts of an acetic acid solution with the mass fraction of 10%, adding the degreased cod skin into the sodium hydroxide solution with the mass fraction of 10%, soaking for 60min at 4 ℃, filtering to obtain a filter cake, washing the filter cake for 5 times with distilled water, draining, adding the filter cake into the sodium hydroxide solution with the mass fraction of 10% for homogenizing, stirring for 40min at the rotating speed of 300r/min at 4 ℃, extracting for 3 days to obtain cod skin mixed slurry, placing the cod skin mixed slurry into a centrifuge, centrifugally separating for 40min at the rotating speed of 4000r/min at 4 ℃, taking supernatant, and freeze-drying to obtain cod skin collagen;
respectively weighing 20 parts of cod skin collagen, 0.2 part of alkaline protease and 200 parts of deionized water according to parts by weight, adding the cod skin collagen into the deionized water, stirring for 10-20 min at normal temperature at 200r/min, dropwise adding a sodium carbonate solution with the mass fraction of 1% to adjust the pH value to 8.2 to obtain a collagen mixed solution, adding the alkaline protease into the collagen mixed solution, stirring for enzymolysis for 60min at the rotating speed of 160r/min under the water bath condition of 55 ℃ to obtain an enzymolysis solution, placing the enzymolysis solution into boiling water, preserving heat and inactivating for 12min, cooling at normal temperature, placing into a centrifuge, centrifuging for 15min at the rotating speed of 8000r/min, and taking supernatant to obtain a cod skin collagen peptide solution;
respectively weighing 40 parts of cod skin collagen peptide solution, 20 parts of glycerol, 20 parts of polyethylene glycol, 4 parts of dimethylpolysiloxane, 8 parts of vaseline, 4 parts of shea butter, 16 parts of cocoa butter, 4 parts of glucose, 2 parts of hydroxyethyl urea, 0.8 part of glyceryl stearate, 0.4 part of polyoxyethylene lauryl ether and 80 parts of deionized water, adding the glucose, the hydroxyethyl urea, the glyceryl stearate and the polyoxyethylene lauryl ether into the deionized water, stirring at the normal temperature at the rotating speed of 300r/min for 30min to obtain an emulsifier mixed solution, adding the emulsifier mixed solution, the glycerol, the polyethylene glycol, the dimethylpolysiloxane, the vaseline, the shea butter and the cocoa butter into the cod skin collagen peptide solution, placing the mixture into a high-shear emulsifying machine, stirring at the rotating speed of 16000r/min under the water bath condition of 50 ℃ for 2h, and placing the mixture into an ultrasonic dispersion machine, and (3) carrying out ultrasonic treatment at the normal temperature for 30min at the power of 600W, and sealing and storing to obtain the antioxidant crease-resistant composite moisturizing cream.
Claims (6)
1. A preparation method of an antioxidant and anti-wrinkling compound moisturizing cream is characterized by comprising the following specific preparation steps:
(1) respectively weighing 20-40 parts by weight of cod skin collagen peptide solution, 10-20 parts by weight of glycerol, 10-20 parts by weight of polyethylene glycol, 2-4 parts by weight of dimethyl polysiloxane, 4-8 parts by weight of vaseline, 2-4 parts by weight of shea butter, 8-16 parts by weight of cocoa butter, 2-4 parts by weight of glucose, 1-2 parts by weight of hydroxyethyl urea, 0.4-0.8 part by weight of glyceryl stearate, 0.2-0.4 part by weight of polyoxyethylene lauryl ether and 40-80 parts by weight of deionized water;
(2) adding glucose, hydroxyethyl urea, glyceryl stearate and polyoxyethylene lauryl ether into deionized water, and stirring at the normal temperature at the rotating speed of 200-300 r/min for 20-30 min to obtain an emulsifier mixed solution;
(3) adding the emulsifier mixed solution, glycerol, polyethylene glycol, dimethyl polysiloxane, vaseline, shea butter and cocoa butter into the cod skin collagen peptide solution, placing the mixture into a high-shear emulsifying machine, stirring the mixture for 1 to 2 hours at a rotating speed of 12000 to 16000r/min under the water bath condition of 40 to 50 ℃, placing the mixture into an ultrasonic dispersion machine, performing ultrasonic treatment for 20 to 30 minutes at normal temperature, and sealing and storing the mixture to obtain the antioxidant crease-resistant composite moisturizing cream.
2. The preparation method of the antioxidant crease-resistant compound moisturizing cream as claimed in claim 1, wherein the power of the ultrasonic treatment in the step (3) is 500-600W.
3. The preparation method of the antioxidant crease-resistant compound moisturizing cream as claimed in claim 1, wherein the specific preparation steps of the cod skin collagen peptide solution in step (1) are as follows:
(1) respectively weighing 10-20 parts by weight of cod skin collagen, 0.1-0.2 part by weight of alkaline protease and 100-200 parts by weight of deionized water;
(2) adding cod skin collagen into deionized water, stirring at the normal temperature for 10-20 min at a speed of 180-200 r/min, and adjusting the pH to 7.8-8.2 to obtain a collagen mixed solution;
(3) adding alkaline protease into the collagen mixed solution, and stirring and performing enzymolysis for 40-60 min at the rotating speed of 120-160 r/min under the water bath condition of 45-55 ℃ to obtain an enzymolysis solution;
(4) and (3) putting the enzymolysis liquid into boiling water, preserving heat and inactivating for 10-12 min, cooling at normal temperature, putting the solution into a centrifugal machine, centrifugally separating for 10-15 min at the rotating speed of 6000-8000 r/min, and taking supernatant to obtain the cod skin collagen peptide solution.
4. The preparation method of the antioxidant crease-resistant compound moisturizing cream as claimed in claim 3, wherein the pH adjustment in step (2) is performed by using a sodium carbonate solution with a mass fraction of 1%.
5. The preparation method of the antioxidant crease-resistant compound moisturizing cream as claimed in claim 3, wherein the cod skin collagen of step (1) is prepared by the following steps:
(1) respectively weighing 20-30 parts by weight of defatted cod skin, 200-300 parts by weight of 10% sodium hydroxide solution and 200-300 parts by weight of 10% acetic acid solution;
(2) adding the degreased cod skin into a sodium hydroxide solution with the mass fraction of 10%, soaking for 40-60 min at the temperature of 2-4 ℃, and filtering to obtain a filter cake;
(3) washing the filter cake with distilled water for 3-5 times, draining, adding 10% by mass of sodium hydroxide solution for homogenizing, stirring at the temperature of 2-4 ℃ at the rotating speed of 200-300 r/min for 30-40 min, and extracting for 1-3 days to obtain cod skin mixed slurry;
(4) and (3) placing the cod skin mixed slurry in a centrifuge, centrifugally separating at the temperature of 2-4 ℃ at the rotating speed of 3000-4000 r/min for 30-40 min, taking supernatant, and freeze-drying to obtain cod skin collagen.
6. The preparation method of the antioxidant crease-resistant compound moisturizing cream as claimed in claim 5, wherein the step (1) of preparing the defatted cod skin comprises the following specific steps:
(1) respectively weighing 10-20 parts of cod skin, 10-20 parts of n-butanol and 100-200 parts of deionized water in parts by weight;
(2) adding n-butyl alcohol into deionized water, and stirring at the normal temperature at the rotating speed of 100-140 r/min for 10-12 min to obtain an n-butyl alcohol solution;
(3) washing the cod skin with tap water for 3-5 times, airing at normal temperature, placing in a n-butyl alcohol solution, standing and soaking for 20-24 hours under a refrigeration condition of 2-4 ℃, and filtering to obtain a filter cake;
(4) washing the filter cake with tap water for 3-5 times, and refrigerating and drying for 1-3 days at 0-4 ℃ to obtain the degreased cod skin.
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Application publication date: 20200207 |