CN108368506A - 用于抑制lpa的基因表达的组合物和方法 - Google Patents

用于抑制lpa的基因表达的组合物和方法 Download PDF

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Publication number
CN108368506A
CN108368506A CN201680057095.8A CN201680057095A CN108368506A CN 108368506 A CN108368506 A CN 108368506A CN 201680057095 A CN201680057095 A CN 201680057095A CN 108368506 A CN108368506 A CN 108368506A
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seq
rnai agent
nucleotide sequence
lpa
lpa rnai
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Pending
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Chinese (zh)
Inventor
S.梅尔奎斯特
S.肯纳
D.B.罗兹马
D.L.路易斯
L.J.阿尔梅达
D.H.沃克菲尔德
V.S.特鲁贝茨科伊
T.裴
Z.李
A.阿尔梅达
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Arrowhead Pharmaceuticals Inc
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Arrowhead Pharmaceuticals Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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CN201680057095.8A 2015-10-01 2016-09-30 用于抑制lpa的基因表达的组合物和方法 Pending CN108368506A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562235816P 2015-10-01 2015-10-01
US62/235816 2015-10-01
US201662346304P 2016-06-06 2016-06-06
US62/346304 2016-06-06
US201662383221P 2016-09-02 2016-09-02
US62/383221 2016-09-02
PCT/US2016/054729 WO2017059223A2 (en) 2015-10-01 2016-09-30 Compositions and methods for inhibiting gene expression of lpa

Publications (1)

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CN108368506A true CN108368506A (zh) 2018-08-03

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CN (1) CN108368506A (https=)
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CL (1) CL2018000803A1 (https=)
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CN113227372A (zh) * 2018-11-13 2021-08-06 赛伦斯治疗有限责任公司 用于抑制细胞中lpa的表达的核酸
CN114703184A (zh) * 2022-03-11 2022-07-05 厦门甘宝利生物医药有限公司 Lpa抑制剂及其用途
WO2023041079A1 (zh) * 2021-09-18 2023-03-23 上海金中锘美生物医药科技有限公司 Lpa抑制剂及其用途
CN115851723A (zh) * 2022-10-24 2023-03-28 厦门甘宝利生物医药有限公司 一种抑制lpa基因表达的rna抑制剂及其应用
WO2024032681A1 (zh) * 2022-08-11 2024-02-15 益杰立科(上海)生物科技有限公司 一种表观编辑靶点的方法及用途
WO2024210530A1 (en) * 2023-04-03 2024-10-10 Olix Pharmaceuticals, Inc. RNAi AGENTS TARGETING LPA GENE AND USE THEREOF
WO2024222686A1 (zh) * 2023-04-24 2024-10-31 上海京新生物医药有限公司 用于抑制LPA表达的RNAi剂及其应用
WO2024240056A1 (zh) 2023-05-19 2024-11-28 深圳信立泰药业股份有限公司 一种磺酰胺类化合物及其制备方法和医药用途
WO2024240212A1 (zh) * 2023-05-24 2024-11-28 云合智药（苏州）生物科技有限公司 用于抑制angptl3表达的rnai剂及其应用
WO2025082058A1 (zh) * 2023-10-16 2025-04-24 润佳(上海)医药技术有限公司 一种抑制LPA基因表达的dsRNA及其用途
WO2025103457A1 (zh) * 2023-11-17 2025-05-22 纳肽得(青岛)生物医药有限公司 抑制LPA表达的siRNA及其用途
WO2025103391A1 (zh) * 2023-11-15 2025-05-22 北京加科瑞康医药科技有限公司 用于抑制lpa的基因表达的sirna，含其的组合物及其用途
WO2025119212A1 (zh) * 2023-12-05 2025-06-12 广东东阳光药业股份有限公司 一种新型的双链siRNA、其缀合物及其用途
CN120344664A (zh) * 2023-10-27 2025-07-18 北京安龙生物医药有限公司 靶向脂蛋白a的寡核苷酸及其用途

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