CN108349997B - 色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途 - Google Patents

色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途 Download PDF

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Publication number
CN108349997B
CN108349997B CN201680063267.2A CN201680063267A CN108349997B CN 108349997 B CN108349997 B CN 108349997B CN 201680063267 A CN201680063267 A CN 201680063267A CN 108349997 B CN108349997 B CN 108349997B
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group
compound
phenyl
pyridin
dimethylisoxazolo
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CN108349997A (zh
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B·D·帕尔默
L-M·秦
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Auckland Uniservices Ltd
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Auckland Uniservices Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN201680063267.2A 2015-08-27 2016-08-25 色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途 Active CN108349997B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ71151415 2015-08-27
NZ711514 2015-08-27
PCT/NZ2016/050135 WO2017034420A1 (en) 2015-08-27 2016-08-25 Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy

Publications (2)

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CN108349997A CN108349997A (zh) 2018-07-31
CN108349997B true CN108349997B (zh) 2025-06-10

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Country Status (9)

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US (2) US11414428B2 (OSRAM)
EP (1) EP3350188B1 (OSRAM)
JP (2) JP7334041B2 (OSRAM)
KR (1) KR20180048798A (OSRAM)
CN (1) CN108349997B (OSRAM)
AU (2) AU2016312848A1 (OSRAM)
CA (1) CA2996681C (OSRAM)
WO (1) WO2017034420A1 (OSRAM)
ZA (1) ZA201800787B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108349997B (zh) * 2015-08-27 2025-06-10 奥克兰联合服务有限公司 色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途
CN108969522B (zh) 2017-06-05 2023-03-28 复旦大学 N-苄基色胺酮类衍生物作为色氨酸双加氧酶(tdo)抑制剂的用途
GB201809050D0 (en) 2018-06-01 2018-07-18 E Therapeutics Plc Modulators of tryptophan catabolism
CN112823036B (zh) * 2018-07-03 2024-11-08 艾福姆德尤股份有限公司 用于治疗与sting活性有关的疾病的化合物和组合物
WO2022150585A1 (en) 2021-01-08 2022-07-14 Ifm Due, Inc. Heterobicyclic compounds having an urea or analogue and their compositions for treating conditions associated with sting activity
BR112023017582A2 (pt) 2021-03-05 2023-12-05 Univ Basel Composições para o tratamento de doenças ou condições associadas ao ebv
EP4052705A1 (en) 2021-03-05 2022-09-07 Universität Basel Vizerektorat Forschung Compositions for the treatment of ebv associated diseases or conditions
EP4486342A2 (en) 2022-03-04 2025-01-08 Antido Therapeutics International Sàrl Dual inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1813606A1 (en) * 2004-11-18 2007-08-01 Takeda Pharmaceutical Company Limited Amide compound

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001255410A1 (en) 2000-04-14 2001-10-30 Corvas International, Inc. Substituted hydrazinyl heteroaromatic inhibitors of thrombin
JP2007529468A (ja) * 2004-03-16 2007-10-25 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ベンズイソオキサゾール
DE102005018389A1 (de) 2005-04-20 2006-10-26 Sanofi-Aventis Deutschland Gmbh Azolderivate als Inhibitoren von Lipasen und Phospholipasen
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
DE102005026194A1 (de) 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
EP2227233B1 (en) 2007-11-30 2013-02-13 Newlink Genetics Ido inhibitors
WO2010068453A1 (en) 2008-11-25 2010-06-17 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
US8598356B2 (en) * 2008-11-25 2013-12-03 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
MX2011008825A (es) 2009-03-10 2011-09-21 Gruenenthal Gmbh 3-aminoisoxazolopiridinas sustituidas como moduladores de kcnq2/3.
CA2789434A1 (en) 2010-02-11 2011-08-18 Vanderbilt University Benzisoxazoles and azabenzisoxazoles as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
AU2011281606B2 (en) 2010-07-22 2016-01-07 Basf Se Herbicidal isoxazolo[5,4-b]pyridines
JP2015504889A (ja) 2012-01-12 2015-02-16 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ 除草性イソオキサゾロ［５，４−ｂ］ピリジン
PL220630B1 (pl) 2012-12-28 2015-11-30 Inst Immunologii I Terapii Doświadczalnej Pan Nowe sulfonamidowe pochodne izoksazolo[5,4-b]pirydyny o aktywności przeciwbakteryjnej, sposób ich wytwarzania oraz nowe zastosowanie 3-aminoizoksazolo[5,4-b]pirydyny
PE20151719A1 (es) * 2013-03-14 2015-11-19 Curadev Pharma Private Ltd Inhibidores de la ruta de quinurenina
EP3082802B1 (en) 2013-12-03 2020-02-26 Iomet Pharma Ltd. Tryptophan-2,3-dioxygenase (tdo) and/or indolamine-2,3-dioxygenase (ido) inhibitors and their use
KR20170034439A (ko) 2014-08-13 2017-03-28 오클랜드 유니서비시즈 리미티드 트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도
CN108349997B (zh) * 2015-08-27 2025-06-10 奥克兰联合服务有限公司 色氨酸双加氧酶（ido1和tdo）抑制剂及其在治疗中的用途
RU2619120C1 (ru) 2016-06-06 2017-05-12 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" 5-Хлор-3-(3-хлорфенилкарбоксамидо)-4,6-диметилизоксазоло[5,4-b]пиридин в качестве антидота 2,4-Д на подсолнечнике

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1813606A1 (en) * 2004-11-18 2007-08-01 Takeda Pharmaceutical Company Limited Amide compound

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Heteroaryl urea inhibitors of fatty acid amide hydrolase: Structure–mutagenicity relationships for arylamine metabolites;Mark S.Tichenor et al.;《Bioorganic & Medicinal Chemistry Letters》;20121022;第22卷(第4期);7357-7362 *
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW SULFONAMIDE ISOXAZOLO[5,4-b]PYRIDINE DERIVATIVES;KRYSTYNA POREBA ET AL.;《Acta Poloniae Pharmaceutica-Drug Research》;20150731;第72卷(第4期);727-735 *
SYNTHESIS AND ANTIPROLIFERATIVE ACTIVITY IN VITRO OF NEW 3-SUBSTITUTED AMINOISOXAZOLO[5,4-b]PYRIDINES;KRYSTYNA POREBA ET AL.;《Acta Poloniae Pharmaceutica-Drug Research》;20031231;第60卷(第4期);293-301 *

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Publication number Publication date
KR20180048798A (ko) 2018-05-10
EP3350188A1 (en) 2018-07-25
WO2017034420A1 (en) 2017-03-02
CN108349997A (zh) 2018-07-31
EP3350188A4 (en) 2019-04-03
EP3350188B1 (en) 2024-03-13
CA2996681A1 (en) 2017-03-02
JP2018525430A (ja) 2018-09-06
US20180244692A1 (en) 2018-08-30
CA2996681C (en) 2024-04-09
JP7334041B2 (ja) 2023-08-28
AU2016312848A1 (en) 2018-03-29
AU2021212003A1 (en) 2021-08-26
JP2022033753A (ja) 2022-03-02
US20220411438A1 (en) 2022-12-29
ZA201800787B (en) 2025-08-27
US11414428B2 (en) 2022-08-16
HK1258665A1 (en) 2019-11-15
AU2021212003B2 (en) 2023-09-14

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