JP7334041B2 - トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用 - Google Patents

トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用 Download PDF

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JP7334041B2
JP7334041B2 JP2018511057A JP2018511057A JP7334041B2 JP 7334041 B2 JP7334041 B2 JP 7334041B2 JP 2018511057 A JP2018511057 A JP 2018511057A JP 2018511057 A JP2018511057 A JP 2018511057A JP 7334041 B2 JP7334041 B2 JP 7334041B2
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JP2018525430A5 (OSRAM
JP2018525430A (ja
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デスモンド パルマー ブライアン
チン ライ－ミン
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オークランド ユニサービシーズ リミティド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2018511057A 2015-08-27 2016-08-25 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用 Active JP7334041B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021182007A JP2022033753A (ja) 2015-08-27 2021-11-08 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NZ711514 2015-08-27
NZ71151415 2015-08-27
PCT/NZ2016/050135 WO2017034420A1 (en) 2015-08-27 2016-08-25 Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy

Related Child Applications (1)

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JP2021182007A Division JP2022033753A (ja) 2015-08-27 2021-11-08 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用

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JP2018525430A JP2018525430A (ja) 2018-09-06
JP2018525430A5 JP2018525430A5 (OSRAM) 2019-10-10
JP7334041B2 true JP7334041B2 (ja) 2023-08-28

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JP2018511057A Active JP7334041B2 (ja) 2015-08-27 2016-08-25 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用
JP2021182007A Pending JP2022033753A (ja) 2015-08-27 2021-11-08 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用

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JP2021182007A Pending JP2022033753A (ja) 2015-08-27 2021-11-08 トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の阻害剤及び治療におけるその使用

Country Status (9)

Country Link
US (2) US11414428B2 (OSRAM)
EP (1) EP3350188B1 (OSRAM)
JP (2) JP7334041B2 (OSRAM)
KR (1) KR20180048798A (OSRAM)
CN (1) CN108349997B (OSRAM)
AU (2) AU2016312848A1 (OSRAM)
CA (1) CA2996681C (OSRAM)
WO (1) WO2017034420A1 (OSRAM)
ZA (1) ZA201800787B (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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WO2017034420A1 (en) * 2015-08-27 2017-03-02 Auckland Uniservices Limited Inhibitors of tryptophan dioxygenases (ido1 and tdo) and their use in therapy
WO2018223969A1 (zh) * 2017-06-05 2018-12-13 复旦大学 N-苄基色胺酮类衍生物作为色氨酸双加氧酶(tdo)抑制剂的用途
GB201809050D0 (en) 2018-06-01 2018-07-18 E Therapeutics Plc Modulators of tryptophan catabolism
US11618749B2 (en) 2018-07-03 2023-04-04 Ifm Due, Inc. Compounds and compositions for treating conditions associated with STING activity
JP2024502474A (ja) 2021-01-08 2024-01-19 アイエフエム デュー インコーポレイテッド Ｓｔｉｎｇ活性に関連する状態を治療するための、尿素を有するヘテロ二環式化合物または類似体およびその組成物
BR112023017582A2 (pt) 2021-03-05 2023-12-05 Univ Basel Composições para o tratamento de doenças ou condições associadas ao ebv
EP4052705A1 (en) 2021-03-05 2022-09-07 Universität Basel Vizerektorat Forschung Compositions for the treatment of ebv associated diseases or conditions
JP2025507981A (ja) 2022-03-04 2025-03-21 アンティド セラピューティクス インターナショナル ソシエテ ア レスポンサビリテ リミティー トリプトファンジオキシゲナーゼ（ｉｄｏ１及びｔｄｏ）の二重阻害剤と療法におけるそれらの使用

Citations (1)

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JP2008536884A (ja) 2005-04-20 2008-09-11 サノフィ−アベンティス リパーゼ及びホスホリパーゼの阻害剤の形態のアゾール誘導体

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EP1746991A2 (en) * 2004-03-16 2007-01-31 Janssen Pharmaceutica N.V. Daao inhibiting benzisoxazoles for treating mental disorders
TW200633990A (en) * 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
DE102005038947A1 (de) * 2005-05-18 2006-11-30 Grünenthal GmbH Substituierte Benzo[d]isoxazol-3-yl-amin-Verbindungen und deren Verwendung in Arzneimitteln
DE102005026194A1 (de) 2005-06-06 2006-12-07 Grünenthal GmbH Substituierte N-Benzo[d]isoxazol-3-yl-amin-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
CA2932121A1 (en) 2007-11-30 2009-06-11 Newlink Genetics Corporation Ido inhibitors
US8598356B2 (en) * 2008-11-25 2013-12-03 Janssen Pharmaceutica Nv Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
US8461159B2 (en) 2008-11-25 2013-06-11 Jannsen Pharmaceutica BV Heteroaryl-substituted urea modulators of fatty acid amide hydrolase
MX2011008825A (es) 2009-03-10 2011-09-21 Gruenenthal Gmbh 3-aminoisoxazolopiridinas sustituidas como moduladores de kcnq2/3.
EP2533642A4 (en) 2010-02-11 2013-08-07 Univ Vanderbilt BENZOOXAZOLE AND AZABENOX OXAZOLE AS ALLOSTERIC MGLUR4 POTENTRANS AND COMPOSITIONS AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTIONS
EA022263B1 (ru) 2010-07-22 2015-11-30 Басф Се Гербицидные изоксазоло[5,4-в]пиридины
IN2014CN04204A (OSRAM) 2012-01-12 2015-07-17 Basf Se
PL220630B1 (pl) 2012-12-28 2015-11-30 Inst Immunologii I Terapii Doświadczalnej Pan Nowe sulfonamidowe pochodne izoksazolo[5,4-b]pirydyny o aktywności przeciwbakteryjnej, sposób ich wytwarzania oraz nowe zastosowanie 3-aminoizoksazolo[5,4-b]pirydyny
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KR20170034439A (ko) 2014-08-13 2017-03-28 오클랜드 유니서비시즈 리미티드 트립토판 디옥시게나제 (ido1 및 tdo)의 억제제 및 치료에서 이들의 용도
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RU2619120C1 (ru) 2016-06-06 2017-05-12 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" 5-Хлор-3-(3-хлорфенилкарбоксамидо)-4,6-диметилизоксазоло[5,4-b]пиридин в качестве антидота 2,4-Д на подсолнечнике

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Ａｃｔａ Ｐｏｌｏｎｉａｅ Ｐｈａｒｍａｃｅｕｔｉｃａ－Ｄｒｕｇ Ｒｅｓｅａｒｃｈ，２００３， Ｖｏｌ．６０， Ｎｏ．４，ｐｐ．２９３－３０１
Ａｃｔａ Ｐｏｌｏｎｉａｅ Ｐｈａｒｍａｃｅｕｔｉｃａ－Ｄｒｕｇ Ｒｅｓｅａｒｃｈ，２０１５．０８．０３， Ｖｏｌ．７２， Ｎｏ．４，ｐｐ．７２７－７３５

Also Published As

Publication number Publication date
EP3350188B1 (en) 2024-03-13
US20180244692A1 (en) 2018-08-30
AU2021212003B2 (en) 2023-09-14
US20220411438A1 (en) 2022-12-29
EP3350188A1 (en) 2018-07-25
HK1258665A1 (en) 2019-11-15
JP2022033753A (ja) 2022-03-02
CN108349997A (zh) 2018-07-31
AU2021212003A1 (en) 2021-08-26
CA2996681A1 (en) 2017-03-02
US11414428B2 (en) 2022-08-16
ZA201800787B (en) 2025-08-27
AU2016312848A1 (en) 2018-03-29
CN108349997B (zh) 2025-06-10
JP2018525430A (ja) 2018-09-06
KR20180048798A (ko) 2018-05-10
EP3350188A4 (en) 2019-04-03
WO2017034420A1 (en) 2017-03-02
CA2996681C (en) 2024-04-09

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