CN1083244C - 特殊晶型的盐酸齐哌特罗,其制备方法及所用的中间产物 - Google Patents

特殊晶型的盐酸齐哌特罗,其制备方法及所用的中间产物 Download PDF

Info

Publication number
CN1083244C
CN1083244C CN96110424A CN96110424A CN1083244C CN 1083244 C CN1083244 C CN 1083244C CN 96110424 A CN96110424 A CN 96110424A CN 96110424 A CN96110424 A CN 96110424A CN 1083244 C CN1083244 C CN 1083244C
Authority
CN
China
Prior art keywords
hydrochloride
trihydrate
zilpaterol
preparation
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN96110424A
Other languages
English (en)
Chinese (zh)
Other versions
CN1147902A (zh
Inventor
Y·塞夫里蒙
J·V·戈达
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intervet International BV
Original Assignee
Hearst Russo Witt
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hearst Russo Witt, Roussel Uclaf SA filed Critical Hearst Russo Witt
Publication of CN1147902A publication Critical patent/CN1147902A/zh
Application granted granted Critical
Publication of CN1083244C publication Critical patent/CN1083244C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/116—Heterocyclic compounds
    • A23K20/137—Heterocyclic compounds containing two hetero atoms, of which at least one is nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S426/00—Food or edible material: processes, compositions, and products
    • Y10S426/807—Poultry or ruminant feed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Husbandry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CN96110424A 1995-06-13 1996-06-12 特殊晶型的盐酸齐哌特罗,其制备方法及所用的中间产物 Expired - Lifetime CN1083244C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9506966 1995-06-13
FR9506966A FR2735474B1 (fr) 1995-06-13 1995-06-13 Chlorhydrate de zilpaterol sous une forme cristallisee particuliere, son procede de preparation et les produits intermediaires mis en oeuvre

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB021030898A Division CN1164591C (zh) 1995-06-13 1996-06-12 盐酸齐哌特罗单水合物

Publications (2)

Publication Number Publication Date
CN1147902A CN1147902A (zh) 1997-04-23
CN1083244C true CN1083244C (zh) 2002-04-24

Family

ID=9479897

Family Applications (2)

Application Number Title Priority Date Filing Date
CN96110424A Expired - Lifetime CN1083244C (zh) 1995-06-13 1996-06-12 特殊晶型的盐酸齐哌特罗,其制备方法及所用的中间产物
CNB021030898A Expired - Lifetime CN1164591C (zh) 1995-06-13 1996-06-12 盐酸齐哌特罗单水合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB021030898A Expired - Lifetime CN1164591C (zh) 1995-06-13 1996-06-12 盐酸齐哌特罗单水合物

Country Status (21)

Country Link
US (2) US5731028A (enExample)
EP (1) EP0753518B1 (enExample)
JP (1) JP4249273B2 (enExample)
KR (1) KR100395204B1 (enExample)
CN (2) CN1083244C (enExample)
AT (1) ATE196471T1 (enExample)
AU (1) AU701653B2 (enExample)
BR (1) BR9602788A (enExample)
CA (1) CA2178783C (enExample)
DE (1) DE69610374T2 (enExample)
DK (1) DK0753518T3 (enExample)
EA (1) EA000011B1 (enExample)
ES (1) ES2151999T3 (enExample)
FR (1) FR2735474B1 (enExample)
GR (1) GR3034458T3 (enExample)
HU (1) HU220461B1 (enExample)
IN (1) IN2014DE02233A (enExample)
MX (1) MX9602307A (enExample)
PT (1) PT753518E (enExample)
UA (1) UA48941C2 (enExample)
ZA (1) ZA964977B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956308A (en) * 1987-01-20 1990-09-11 Itt Corporation Method of making self-aligned field-effect transistor
KR100344157B1 (ko) * 2000-01-06 2002-07-31 주식회사 하이테크 그라스 배경무늬 형성을 위한 장식판 도포제재 및 장식판의배경무늬 형성방법
US7207289B2 (en) * 2004-05-20 2007-04-24 Intervet International B.V. Method of feeding the cattle with feed additives that increases beef production and reduces liver abscess
AU2008209743B2 (en) 2007-02-01 2011-03-24 Intervet International B.V. Enantioselective synthesis of 6-amino-7-hydroxy-4, 5, 6, 7-tetrahydro-imidazo [4, 5, 1-jk] [1] -benzazepin-2 [1H] -one and zilpaterol
BRPI0809493B1 (pt) 2007-03-31 2016-11-08 Intervet Int Bv processo para preparar zilpaterol ou um sal deste
KR101240147B1 (ko) * 2007-03-31 2013-03-08 인터벳 인터내셔널 비.브이. 질파테롤 및 이의 염의 제조 방법
JP5856990B2 (ja) * 2007-03-31 2016-02-10 インターベット インターナショナル ベー． フェー． ジルパテロールおよびこの塩の製造方法
WO2009073756A1 (en) 2007-12-06 2009-06-11 Intervet International B.V. Combination therapies using melengestrol acetate and zilpaterol or its salts
TW201033217A (en) 2008-12-17 2010-09-16 Intervet Int Bv Process for making a crystalline zilpaterol salt
CN104284598A (zh) 2012-05-18 2015-01-14 英特维特国际股份有限公司 增强肉用仔鸡性能的方法
KR102214967B1 (ko) 2012-12-18 2021-02-10 인터벳 인터내셔널 비.브이. 개선된 질파테롤 제조 공정
MX2015012726A (es) 2013-03-15 2016-02-18 Intervet Int Bv Metodo para mejorar la eficiencia de la produccion de carne de animales bovinos.
US9364483B2 (en) 2014-06-20 2016-06-14 Laboratorios Virbac Pre-mix composition for cattle
CN105334323A (zh) * 2014-08-07 2016-02-17 暨南大学 一种检测齐帕特罗的方法和试纸条及其应用
BR112018001066A2 (pt) 2015-07-21 2018-09-11 Intervet Int Bv pré-mistura de ração para animais, processo para preparação de pré-mistura de ração para animais, método para preparação de uma ração para animais, e, uso de uma pré-mistura de ração para animais
EP3488705A1 (en) 2017-11-23 2019-05-29 Saviela AG Solubilized growth promoting product to be applied orally to animals and method for the respective feed preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534257A1 (fr) * 1982-10-12 1984-04-13 Roussel Uclaf Nouveaux derives de la 6-amino 7-hydroxy 4,5,6,7-tetrahydro-imidazo/4,5,1-j-k/ /1/ benzazepin-2(1h)-one, leurs sels, application a titre de medicaments, compositions les renfermant et un intermediaire
US4497779A (en) * 1983-10-14 1985-02-05 Amax Inc. Production of potassium hexafluotitanates using dilute hydrofluoric acid
IE60588B1 (en) * 1986-07-30 1994-07-27 Sumitomo Pharma Carbapenem compound in crystalline form, and its production and use
IE60964B1 (en) * 1986-12-11 1994-09-07 Roussel Uclaf Zootechnical compositions containing a beta-adrenergic
FR2608046B1 (fr) * 1986-12-11 1989-03-31 Roussel Uclaf Compositions zootechniques renfermant un derive de la 6-amino 7-hydroxy 4,5,6,7-tetrahydroimidazo /4,5, 1-j-k/ /1/benzazepin-2-(1h)-one
FR2647310B1 (fr) * 1989-05-29 1992-01-17 Roussel Uclaf Utilisation de beta-adrenergiques pour la fabrication de compositions zootechniques
ES2199224T3 (es) * 1992-12-04 2004-02-16 Janssen Pharmaceutica N.V. Derivados de imidazo(1,2-a)tieno(2,3-d)azepina antialergicos.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
HUP9601617A2 (en) 1997-06-30
EA000011B1 (ru) 1997-12-30
DK0753518T3 (da) 2001-01-29
KR100395204B1 (ko) 2003-11-17
ATE196471T1 (de) 2000-10-15
DE69610374D1 (de) 2000-10-26
EA199600027A2 (ru) 1996-12-30
AU701653B2 (en) 1999-02-04
CN1147902A (zh) 1997-04-23
US5847124A (en) 1998-12-08
PT753518E (pt) 2000-12-29
CA2178783C (fr) 2005-04-12
HU9601617D0 (en) 1996-08-28
GR3034458T3 (en) 2000-12-29
EP0753518B1 (fr) 2000-09-20
FR2735474A1 (fr) 1996-12-20
EP0753518A1 (fr) 1997-01-15
JP4249273B2 (ja) 2009-04-02
EA199600027A3 (ru) 1997-03-31
IN2014DE02233A (enExample) 2015-06-19
JPH093069A (ja) 1997-01-07
AU5592596A (en) 1997-01-02
KR970001215A (ko) 1997-01-21
HUP9601617A3 (en) 1999-07-28
FR2735474B1 (fr) 1997-08-08
CN1396165A (zh) 2003-02-12
UA48941C2 (uk) 2002-09-16
CN1164591C (zh) 2004-09-01
MX9602307A (es) 1998-04-30
CA2178783A1 (fr) 1996-12-14
US5731028A (en) 1998-03-24
HU220461B1 (hu) 2002-02-28
ES2151999T3 (es) 2001-01-16
DE69610374T2 (de) 2001-01-25
ZA964977B (en) 1997-06-12
BR9602788A (pt) 1998-09-08

Similar Documents

Publication Publication Date Title
CN1083244C (zh) 特殊晶型的盐酸齐哌特罗,其制备方法及所用的中间产物
US5463116A (en) Crystals of N- (trans-4-isopropylcyclohexlycarbonyl)-D-phenylalanine and methods for preparing them
JPH08512315A (ja) オメプラゾールマグネシウム
JP2011524907A (ja) 固体ラサギリン塩基を調製および乾燥する方法
HU211126A9 (en) Pharmaceutical agents
EA019303B1 (ru) Способ получения мемантина и его гидрохлорида
MXPA96002307A (en) Zilpaterol chlorhydrate in a particular crystallized form, its preparation procedure and the intermediate products employ
EP3997062B1 (de) Metastabile kristallmodifikation und verfahren zu deren herstellung (i)
DE69112099T2 (de) Kristallinisches Salz von 4-(Di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indol.
MXPA04007995A (es) Desolvatacion de solvatos de hemicalcio de atorvastatina.
DE60006814T2 (de) Dinucleotid-kristalle
JP4538842B2 (ja) 新規ナテグリニド結晶
RU2586117C2 (ru) Кристаллизация гидрохлорида эпирубицина
CN1129453A (zh) 热力学稳定的结晶态4″-脱氧-4″-表甲氨基阿佛曼菌素Bla/Blb苯甲酸盐及其制备方法
CS252465B2 (en) Insecticide and acaricide
JPH10508878A (ja) （ｓ）−ｎ，ｎ’−ビス［２−ヒドロキシ−１−（ヒドロキシメチル）エチル］−５−［（２−ヒドロキシ−１−オキソプロピル）アミノ］−２，４，６−トリヨード−１，３−ベンゼンジカルボキサアミドの、水からの結晶化方法
JPWO2021186258A5 (enExample)
JP6076736B2 (ja) １−アミノ−１，３，３，５，５−ペンタメチルシクロヘキサンメシラートの合成
DE102019118893A1 (de) Metastabile Kristallmodifikation und Verfahren zu deren Herstellung (I)
DE102019118894A1 (de) Metastabile Kristallmodifikation und Verfahren zu deren Herstellung (II)
CZ261390A3 (cs) Deoxyspergualintrihydrochlorid v krystalické formě beta a způsob jeho výroby
JPWO2001098255A1 (ja) パントテン酸カルシウムの製造方法
HK1024230A1 (en) Novel modifications to 2-amino-4-(4-fluorobenzylamino)-1-ethoxycai and processes for preparing said compound

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: INTWELT INTERNATIONAL CO., LTD.

Free format text: FORMER OWNER: HEARST.RUSSO.WITT CO.,LTD.

Effective date: 20051223

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20051223

Address after: Holland box Mel

Patentee after: Intervet Int Bv

Address before: French Roman

Patentee before: Hearst witter. Rousseau.

CX01 Expiry of patent term

Granted publication date: 20020424

EXPY Termination of patent right or utility model