CN108250264A - 制备胆汁酸衍生物的方法 - Google Patents
制备胆汁酸衍生物的方法 Download PDFInfo
- Publication number
- CN108250264A CN108250264A CN201810282054.XA CN201810282054A CN108250264A CN 108250264 A CN108250264 A CN 108250264A CN 201810282054 A CN201810282054 A CN 201810282054A CN 108250264 A CN108250264 A CN 108250264A
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- acceptable salt
- idd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC[C@]1[C@@](*)C(C(CC2)[C@](C)(CC3)[C@]2[C@](C)CCO)C3[C@@](C)(CC[C@](C2)OC(C)=O)[C@]2CC1 Chemical compound CC[C@]1[C@@](*)C(C(CC2)[C@](C)(CC3)[C@]2[C@](C)CCO)C3[C@@](C)(CC[C@](C2)OC(C)=O)[C@]2CC1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718966P | 2012-10-26 | 2012-10-26 | |
| US61/718,966 | 2012-10-26 | ||
| CN201380068062.XA CN105102425B (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380068062.XA Division CN105102425B (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108250264A true CN108250264A (zh) | 2018-07-06 |
Family
ID=50545344
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810282054.XA Pending CN108250264A (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
| CN201380068062.XA Expired - Fee Related CN105102425B (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380068062.XA Expired - Fee Related CN105102425B (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
Country Status (22)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX361653B (es) | 2012-10-26 | 2018-12-13 | Intercept Pharmaceuticals Inc | Procedimiento para la preparación de derivados del ácido biliar. |
| RS64050B1 (sr) | 2014-05-29 | 2023-04-28 | Bar Pharmaceuticals S R L | Derivati holana za upotrebu u lečenju i/ili prevenciji fxr i tgr5/gpbar1 posredovanih bolesti |
| PL3221332T3 (pl) | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr |
| DK3221333T3 (da) | 2014-11-19 | 2019-09-30 | Nzp Uk Ltd | 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer |
| BR112017010319B1 (pt) | 2014-11-19 | 2023-04-11 | NZP UK Limited | Esteroides 6-alquil-7-hidróxi-4-en-3-ona e processo para a preparação dos mesmos |
| WO2016079520A1 (en) | 2014-11-19 | 2016-05-26 | Dextra Laboratories Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| CN104672290B (zh) * | 2015-01-05 | 2017-06-06 | 北京普禄德医药科技有限公司 | 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途 |
| EA036404B1 (ru) | 2015-02-06 | 2020-11-06 | Интерсепт Фармасьютикалз, Инк. | Фармацевтические композиции для комбинированной терапии |
| KR20180052756A (ko) * | 2015-09-24 | 2018-05-18 | 인터셉트 파마슈티컬즈, 인크. | 담즙산 유도체 제조를 위한 방법 및 중간체 |
| HK1254055A1 (zh) * | 2015-11-06 | 2019-07-12 | 英特塞普特医药品公司 | 制备奥贝胆酸及其衍生物的方法 |
| WO2017142895A1 (en) * | 2016-02-15 | 2017-08-24 | Regents Of The University Of Minnesota | Compositions and methods for treating clostridium associated diseases |
| CA3020698A1 (en) | 2016-04-13 | 2017-10-19 | Intercept Pharmaceuticals, Inc. | Methods of treating or preventing hepatocellular carcinoma |
| TW201738254A (zh) * | 2016-04-19 | 2017-11-01 | 英特賽普醫藥品公司 | 奧貝膽酸及其衍生物之製備方法 |
| GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| CN109963567A (zh) * | 2016-09-30 | 2019-07-02 | 英特塞普特医药品公司 | 胆汁酸衍生物的结晶形式 |
| CN111050772A (zh) * | 2017-07-24 | 2020-04-21 | 英特塞普特医药品公司 | 同位素标记的胆汁酸衍生物 |
| US11059854B2 (en) * | 2017-07-26 | 2021-07-13 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Method for preparing steroid derivative FXR agonist |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| WO2020243590A1 (en) | 2019-05-30 | 2020-12-03 | Intercept Pharmaceuticals, Inc. | Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease |
| KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
| CA3173731A1 (en) | 2020-02-28 | 2021-09-02 | Kallyope, Inc. | Gpr40 agonists |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| WO2021263039A1 (en) | 2020-06-26 | 2021-12-30 | Kallyope, Inc. | Ampk activators |
| JP7583398B2 (ja) | 2020-09-18 | 2024-11-14 | ソウル大学校産学協力団 | タウロデオキシコール酸ナトリウムの大量生産方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101522703A (zh) * | 2006-06-27 | 2009-09-02 | 英特塞普特医药品公司 | 胆酸派生物作为fxr配基预防或治疗fxr-介导的疾病或状况 |
| CN102164940A (zh) * | 2008-07-30 | 2011-08-24 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216015A (en) | 1991-02-05 | 1993-06-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having hypocholesterolemic properties |
| ATE303399T1 (de) | 2001-03-12 | 2005-09-15 | Intercept Pharmaceuticals Inc | Steroide als agonisten für fxr |
| EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| US9943614B2 (en) * | 2008-06-17 | 2018-04-17 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| US8999964B2 (en) * | 2008-11-19 | 2015-04-07 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| MX361653B (es) | 2012-10-26 | 2018-12-13 | Intercept Pharmaceuticals Inc | Procedimiento para la preparación de derivados del ácido biliar. |
-
2013
- 2013-10-25 MX MX2015005286A patent/MX361653B/es active IP Right Grant
- 2013-10-25 WO PCT/US2013/066917 patent/WO2014066819A1/en not_active Ceased
- 2013-10-25 CN CN201810282054.XA patent/CN108250264A/zh active Pending
- 2013-10-25 CA CA2889592A patent/CA2889592A1/en not_active Abandoned
- 2013-10-25 BR BR112015009395A patent/BR112015009395A2/pt not_active Application Discontinuation
- 2013-10-25 PT PT138492632T patent/PT2912013T/pt unknown
- 2013-10-25 US US14/438,323 patent/US9777038B2/en active Active
- 2013-10-25 HU HUE13849263A patent/HUE036887T2/hu unknown
- 2013-10-25 EP EP13849263.2A patent/EP2912013B1/en not_active Not-in-force
- 2013-10-25 KR KR1020157012805A patent/KR102068381B1/ko not_active Expired - Fee Related
- 2013-10-25 SG SG11201503247UA patent/SG11201503247UA/en unknown
- 2013-10-25 CN CN201380068062.XA patent/CN105102425B/zh not_active Expired - Fee Related
- 2013-10-25 ES ES13849263.2T patent/ES2655034T3/es active Active
- 2013-10-25 AU AU2013334122A patent/AU2013334122B2/en not_active Ceased
- 2013-10-25 NZ NZ745013A patent/NZ745013A/en not_active IP Right Cessation
- 2013-10-25 DK DK13849263.2T patent/DK2912013T3/en active
- 2013-10-25 PL PL13849263T patent/PL2912013T3/pl unknown
- 2013-10-25 SM SM20170602T patent/SMT201700602T1/it unknown
- 2013-10-25 NZ NZ707389A patent/NZ707389A/en not_active IP Right Cessation
- 2013-10-25 JP JP2015539862A patent/JP6272888B2/ja not_active Expired - Fee Related
-
2014
- 2014-03-14 NO NO14725812A patent/NO2968302T3/no unknown
-
2015
- 2015-04-26 IL IL238454A patent/IL238454B/en active IP Right Grant
-
2016
- 2016-02-24 HK HK18112593.6A patent/HK1253301A1/zh unknown
-
2017
- 2017-08-21 US US15/681,609 patent/US10202414B2/en not_active Expired - Fee Related
-
2018
- 2018-01-03 CY CY20181100003T patent/CY1119731T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101522703A (zh) * | 2006-06-27 | 2009-09-02 | 英特塞普特医药品公司 | 胆酸派生物作为fxr配基预防或治疗fxr-介导的疾病或状况 |
| CN102164940A (zh) * | 2008-07-30 | 2011-08-24 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
Non-Patent Citations (2)
| Title |
|---|
| GIOVANNI RIZZO等: "Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist", 《THE AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》 * |
| NORINDER, JAKOB等: "An Enantioselective Route to α-Methyl Carboxylic Acids via Metal and Enzyme Catalysis", 《ORGANIC LETTERS》 * |
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