IL238454B - A process for the preparation of bile acid derivatives - Google Patents
A process for the preparation of bile acid derivativesInfo
- Publication number
- IL238454B IL238454B IL238454A IL23845415A IL238454B IL 238454 B IL238454 B IL 238454B IL 238454 A IL238454 A IL 238454A IL 23845415 A IL23845415 A IL 23845415A IL 238454 B IL238454 B IL 238454B
- Authority
- IL
- Israel
- Prior art keywords
- acid derivatives
- bile acid
- preparing bile
- preparing
- derivatives
- Prior art date
Links
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical class C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718966P | 2012-10-26 | 2012-10-26 | |
| PCT/US2013/066917 WO2014066819A1 (en) | 2012-10-26 | 2013-10-25 | Process for preparing bile acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL238454A0 IL238454A0 (en) | 2015-06-30 |
| IL238454B true IL238454B (en) | 2018-11-29 |
Family
ID=50545344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL238454A IL238454B (en) | 2012-10-26 | 2015-04-26 | A process for the preparation of bile acid derivatives |
Country Status (22)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9777038B2 (en) | 2012-10-26 | 2017-10-03 | Intercept Pharmaceuticals, Inc. | Process for preparing bile acid derivatives |
| ES2938874T3 (es) | 2014-05-29 | 2023-04-17 | Bar Pharmaceuticals S R L | Derivados de colano para su uso en el tratamiento y/o prevención de enfermedades mediadas por FXR y TGR5/GPBAR1 |
| US20170327531A1 (en) | 2014-11-19 | 2017-11-16 | NZP UK Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
| CN107207559B (zh) | 2014-11-19 | 2019-10-25 | Nzp英国有限公司 | 作为制备类固醇fxr调节剂的中间体的6-烷基-7-羟基-4-烯-3-酮类固醇 |
| JP6724004B2 (ja) | 2014-11-19 | 2020-07-15 | エヌゼットピー ユーケー リミテッド | ステロイドＦＸＲモジュレーター製造のための中間体としての５β−６−アルキル−７−ヒドロキシ−３−オンステロイド |
| CN107108688B (zh) | 2014-11-19 | 2019-10-29 | Nzp英国有限公司 | 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇 |
| CN104672290B (zh) * | 2015-01-05 | 2017-06-06 | 北京普禄德医药科技有限公司 | 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途 |
| TN2017000344A1 (en) | 2015-02-06 | 2019-01-16 | Intercept Pharmaceuticals Inc | Pharmaceutical compositions for combination therapy |
| CN108350020A (zh) * | 2015-09-24 | 2018-07-31 | 英特塞普特医药品公司 | 用于制备胆汁酸衍生物的方法和中间体 |
| BR112018008936A2 (pt) * | 2015-11-06 | 2018-11-27 | Intercept Pharmaceuticals Inc | métodos para a preparação de ácido obeticólico e derivados do mesmo |
| US20200262865A1 (en) * | 2016-02-15 | 2020-08-20 | Alexander Khoruts | Compositions and methods for treating clostridium associated diseases |
| KR102377338B1 (ko) | 2016-04-13 | 2022-03-21 | 인터셉트 파마슈티컬즈, 인크. | 암의 치료 방법 |
| TW201738254A (zh) * | 2016-04-19 | 2017-11-01 | 英特賽普醫藥品公司 | 奧貝膽酸及其衍生物之製備方法 |
| GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| CN109963567A (zh) * | 2016-09-30 | 2019-07-02 | 英特塞普特医药品公司 | 胆汁酸衍生物的结晶形式 |
| CA3070837A1 (en) | 2017-07-24 | 2019-01-31 | Intercept Pharmaceuticals, Inc. | Isotopically labeled bile acid derivatives |
| JP7308811B2 (ja) * | 2017-07-26 | 2023-07-14 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | ステロイド系誘導体ｆｘｒアゴニストの製造方法 |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| AU2020284135A1 (en) | 2019-05-30 | 2022-01-06 | Intercept Pharmaceuticals, Inc. | Pharmaceutical compositions comprising a FXR agonist and a fibrate for use in the treatment of cholestatic liver disease |
| IL291985A (en) | 2019-10-07 | 2022-06-01 | Kallyope Inc | Gpr119 agonists |
| PH12022552277A1 (en) | 2020-02-28 | 2024-03-04 | Kallyope Inc | Gpr40 agonists |
| UY39222A (es) | 2020-05-19 | 2021-11-30 | Kallyope Inc | Activadores de la ampk |
| EP4172162A4 (en) | 2020-06-26 | 2024-08-07 | Kallyope, Inc. | AMPK ACTIVATORS |
| EP4215540A4 (en) | 2020-09-18 | 2025-01-15 | Seoul National University R & DB Foundation | METHOD FOR MASS PRODUCTION OF SODIUM TAURODEOXYCHOLATE |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216015A (en) | 1991-02-05 | 1993-06-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having hypocholesterolemic properties |
| DE60205891T2 (de) | 2001-03-12 | 2006-06-22 | Intercept Pharmaceuticals, Inc. | Steroide als agonisten für fxr |
| EP1568706A1 (en) | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| EP2040713B1 (en) * | 2006-06-27 | 2014-06-18 | Intercept Pharmaceuticals Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated deseases or conditions |
| WO2010036427A1 (en) * | 2008-06-17 | 2010-04-01 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| AU2009276507B2 (en) * | 2008-07-30 | 2015-11-19 | Intercept Pharmaceuticals, Inc. | TGR5 modulators and methods of use thereof |
| EP3150620B1 (en) * | 2008-11-19 | 2020-01-08 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
| US9777038B2 (en) | 2012-10-26 | 2017-10-03 | Intercept Pharmaceuticals, Inc. | Process for preparing bile acid derivatives |
-
2013
- 2013-10-25 US US14/438,323 patent/US9777038B2/en active Active
- 2013-10-25 PL PL13849263T patent/PL2912013T3/pl unknown
- 2013-10-25 CN CN201380068062.XA patent/CN105102425B/zh not_active Expired - Fee Related
- 2013-10-25 SM SM20170602T patent/SMT201700602T1/it unknown
- 2013-10-25 BR BR112015009395A patent/BR112015009395A2/pt not_active Application Discontinuation
- 2013-10-25 NZ NZ745013A patent/NZ745013A/en not_active IP Right Cessation
- 2013-10-25 DK DK13849263.2T patent/DK2912013T3/en active
- 2013-10-25 WO PCT/US2013/066917 patent/WO2014066819A1/en not_active Ceased
- 2013-10-25 CN CN201810282054.XA patent/CN108250264A/zh active Pending
- 2013-10-25 SG SG11201503247UA patent/SG11201503247UA/en unknown
- 2013-10-25 NZ NZ707389A patent/NZ707389A/en not_active IP Right Cessation
- 2013-10-25 PT PT138492632T patent/PT2912013T/pt unknown
- 2013-10-25 AU AU2013334122A patent/AU2013334122B2/en not_active Ceased
- 2013-10-25 ES ES13849263.2T patent/ES2655034T3/es active Active
- 2013-10-25 EP EP13849263.2A patent/EP2912013B1/en not_active Not-in-force
- 2013-10-25 KR KR1020157012805A patent/KR102068381B1/ko not_active Expired - Fee Related
- 2013-10-25 JP JP2015539862A patent/JP6272888B2/ja not_active Expired - Fee Related
- 2013-10-25 CA CA2889592A patent/CA2889592A1/en not_active Abandoned
- 2013-10-25 MX MX2015005286A patent/MX361653B/es active IP Right Grant
- 2013-10-25 HU HUE13849263A patent/HUE036887T2/hu unknown
-
2014
- 2014-03-14 NO NO14725812A patent/NO2968302T3/no unknown
-
2015
- 2015-04-26 IL IL238454A patent/IL238454B/en active IP Right Grant
-
2016
- 2016-02-24 HK HK18112593.6A patent/HK1253301A1/zh unknown
-
2017
- 2017-08-21 US US15/681,609 patent/US10202414B2/en not_active Expired - Fee Related
-
2018
- 2018-01-03 CY CY20181100003T patent/CY1119731T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |