CN108185410A - 一种抗肿瘤益生菌发酵功能性食品及其制备方法 - Google Patents
一种抗肿瘤益生菌发酵功能性食品及其制备方法 Download PDFInfo
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- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 description 1
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- 239000008120 corn starch Substances 0.000 description 1
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- 230000000994 depressogenic effect Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
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- 235000013325 dietary fiber Nutrition 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000013024 dilution buffer Substances 0.000 description 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 229960002852 ellagic acid Drugs 0.000 description 1
- 235000004132 ellagic acid Nutrition 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000009920 food preservation Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000006481 glucose medium Substances 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 231100000753 hepatic injury Toxicity 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N hydrochloric acid Substances Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- CXORMDKZEUMQHX-UHFFFAOYSA-N kermesic acid Chemical compound O=C1C2=C(O)C(O)=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C CXORMDKZEUMQHX-UHFFFAOYSA-N 0.000 description 1
- 150000002584 ketoses Chemical class 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
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- 231100000225 lethality Toxicity 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 230000002246 oncogenic effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001175 peptic effect Effects 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 210000003024 peritoneal macrophage Anatomy 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 235000015136 pumpkin Nutrition 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 235000021055 solid food Nutrition 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
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- 235000019640 taste Nutrition 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
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- 230000003612 virological effect Effects 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
Description
12h | 24h | 36h | 48h | |
1号 | 3.8×108 | 5.8×108 | 3.5×108 | 3.9×108 |
2号 | 4.2×108 | 6.9×108 | 3.6×108 | 6.4×108 |
3号 | 8.4×107 | 9.5.×107 | 7.5×107 | 7.9×107 |
4号 | 8.6×107 | 8.9×107 | 8.1×107 | 6.2×107 |
5号 | 6.8×107 | 7.6×107 | 5.9×107 | 3.9×107 |
6号 | 5.8×105 | 4.9×105 | 3.8×105 | 4.2×105 |
总活菌数 | 9.3×108 | 4.5×109 | 2.7×109 | 3.6×109 |
组合一 | 组合二 | 组合三 | 组合四 | 组合五 | |
1号 | 1.6×108 | 2.7×108 | 5.2×108 | 5.5×108 | 8.4×108 |
2号 | 2.7×107 | 4.8×107 | 4.1×107 | 4.9×107 | 9.3×108 |
3号 | 5.9×107 | 6.2×107 | 7.3×107 | 6.4×108 | 7.7×108 |
4号 | 3.6×107 | 7.7×107 | 4.9×108 | 7.1×108 | 4.6×108 |
5号 | 1.7×107 | 3.5×107 | 7.5×107 | 3.7×107 | 6.1×108 |
6号 | 4.5×105 | 7.4×105 | 8.8×105 | 9.6×107 | 7.4×107 |
总活菌数 | 1.7×1010 | 7.3×109 | 9.8×108 | 1.4×109 | 1.9×1010 |
比例 | 1:0.8 | 1:1 | 1:1.2 | 1:1.6 | 1:1.8 | 1:2 |
TK9单菌 | 3.3×108 | 8.8×108 | 6.5×108 | 3.2×108 | 3.8×108 | 1.5×108 |
937单菌 | 4.7×107 | 6.7×108 | 3.3×108 | 2.8×108 | 5.6×108 | 2.6×108 |
TK1501 | 8.8×107 | 5.6×108 | 3.9×108 | 4.5×108 | 2.8×108 | 3.3×108 |
TK99 | 2.6×107 | 7.8×108 | 4.4×108 | 5.8×108 | 4.9×108 | 2.7×108 |
TQ33 | 7.3×107 | 5.8×107 | 7.5×108 | 7.3×107 | 8.6×107 | 6.5×107 |
TK-1 | 3.9×107 | 7.9×107 | 7.3×107 | 6.7×107 | 5.4×107 | 4.2×107 |
总活菌数 | 6.8×108 | 9.7×109 | 6.7×109 | 2.8×109 | 2.1×109 | 3.9×109 |
12h | 24h | 36h | 48h | |
1号 | 4.8×108 | 5.6×108 | 6.7×108 | 7.6×108 |
2号 | 2.2×108 | 2.7×108 | 3.7×108 | 2.9×108 |
3号 | 5.1×107 | 6.3×107 | 6.3×108 | 4.3×108 |
4号 | 8.4×107 | 7.6×107 | 1.8×108 | 1.0×108 |
5号 | 5.3×106 | 1.8×107 | 1.6×107 | 9.3×106 |
6号 | 3.7×105 | 3.3×105 | 3.4×105 | 2.8×105 |
总活菌数 | 5.5×109 | 8.4×109 | 1.6×1010 | 8.6×109 |
产品浓度(mg/mL) | 80ID细胞最大抑制率 | J744.I细胞最大抑制率 |
0.5 | 45.26±3.34 | 10.21±1.00 |
1.0 | 53.13±2.17 | 11.32±0.45 |
5.0 | 66.58±3.62 | 13.84±0.45 |
25.0 | 74.26±1.37 | 15.26±0.57 |
125.0 | 87.38±4.66 | 27.89±1.41 |
IC50(mg/mL) | 19.52±4.04 | >100 |
产品浓度(mg/g) | 80ID细胞最大抑制率 | J744.I细胞最大抑制率 |
0.5 | 53.26±3.43 | 12.67±0.46 |
1.0 | 55.13±2.54 | 13.85±0.43 |
5.0 | 68.75±2.86 | 15.67±0.38 |
25.0 | 84.33±4.37 | 20.33±0.24 |
125.0 | 97.28±3.95 | 30.69±0.34 |
IC50(mg/g) | 10.52±4.65 | >100 |
组别 | n | 瘤重 | 抑制率 |
模型组 | 10 | 1.05±0.35 | — |
喂食姜黄发酵液态饮料组 | 10 | 0.31±0.15 | 69.73% |
喂食姜黄发酵固态食品组 | 10 | 0.24±0.26 | 76.33% |
Claims (10)
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110521785A (zh) * | 2019-09-26 | 2019-12-03 | 天津创源生物技术有限公司 | 益生菌发酵功能性食品及其制备 |
CN110537704A (zh) * | 2019-09-09 | 2019-12-06 | 天津创源生物技术有限公司 | 一种改善睡眠的益生菌发酵功能食品及其制备方法 |
CN111281971A (zh) * | 2020-03-13 | 2020-06-16 | 张明洞 | 一种具有降低血粘度的药物组合物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103316301A (zh) * | 2013-07-02 | 2013-09-25 | 安徽省康美来大别山生物科技有限公司 | 一种去除姜黄苦味的方法 |
CN105942084A (zh) * | 2016-04-28 | 2016-09-21 | 天津科技大学 | 荞麦发酵生产益生菌功能性食品 |
-
2017
- 2017-12-13 CN CN201711324944.4A patent/CN108185410A/zh active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103316301A (zh) * | 2013-07-02 | 2013-09-25 | 安徽省康美来大别山生物科技有限公司 | 一种去除姜黄苦味的方法 |
CN105942084A (zh) * | 2016-04-28 | 2016-09-21 | 天津科技大学 | 荞麦发酵生产益生菌功能性食品 |
Non-Patent Citations (1)
Title |
---|
沃兴德,等: "姜黄素及其衍生物抑制肿瘤作用的实验研究", 《浙江中医学院学报》 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110537704A (zh) * | 2019-09-09 | 2019-12-06 | 天津创源生物技术有限公司 | 一种改善睡眠的益生菌发酵功能食品及其制备方法 |
CN110521785A (zh) * | 2019-09-26 | 2019-12-03 | 天津创源生物技术有限公司 | 益生菌发酵功能性食品及其制备 |
CN111281971A (zh) * | 2020-03-13 | 2020-06-16 | 张明洞 | 一种具有降低血粘度的药物组合物 |
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