CN108136206B - 抗乙型肝炎病毒的组合物和药剂及其用途 - Google Patents

抗乙型肝炎病毒的组合物和药剂及其用途 Download PDF

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CN108136206B
CN108136206B CN201680053632.1A CN201680053632A CN108136206B CN 108136206 B CN108136206 B CN 108136206B CN 201680053632 A CN201680053632 A CN 201680053632A CN 108136206 B CN108136206 B CN 108136206B
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CN108136206A (zh
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P·林姆冯
立川洁
C·以扫
帕德马纳巴·契吾库拉
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end

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CN201680053632.1A 2015-07-17 2016-07-17 抗乙型肝炎病毒的组合物和药剂及其用途 Expired - Fee Related CN108136206B (zh)

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US201562193997P 2015-07-17 2015-07-17
US62/193,997 2015-07-17
PCT/US2016/042694 WO2017015175A1 (en) 2015-07-17 2016-07-17 Compositions and agents against hepatitis b virus and uses thereof

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CA (1) CA2996722A1 (enExample)
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US10961535B2 (en) 2021-03-30
AU2016296592B2 (en) 2021-08-19
CA2996722A1 (en) 2017-01-26
EP3325097A4 (en) 2019-07-10
EP3325097A1 (en) 2018-05-30
AU2016296592A1 (en) 2018-03-08
CN108136206A (zh) 2018-06-08
TWI761311B (zh) 2022-04-21
WO2017015175A1 (en) 2017-01-26
US20170016000A1 (en) 2017-01-19
US20180371463A1 (en) 2018-12-27
EP3325097B1 (en) 2021-09-01
JP2018520685A (ja) 2018-08-02
TW201803989A (zh) 2018-02-01
JP6924744B2 (ja) 2021-08-25

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