CN108135861A - 干式贴 - Google Patents
干式贴 Download PDFInfo
- Publication number
- CN108135861A CN108135861A CN201680059051.9A CN201680059051A CN108135861A CN 108135861 A CN108135861 A CN 108135861A CN 201680059051 A CN201680059051 A CN 201680059051A CN 108135861 A CN108135861 A CN 108135861A
- Authority
- CN
- China
- Prior art keywords
- dry type
- wound
- mentioned
- fiber
- hydrophilic macromolecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010052428 Wound Diseases 0.000 claims abstract description 79
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 79
- 239000000835 fiber Substances 0.000 claims abstract description 47
- 229920002521 macromolecule Polymers 0.000 claims abstract description 41
- 239000003357 wound healing promoting agent Substances 0.000 claims abstract description 35
- 210000000416 exudates and transudate Anatomy 0.000 claims abstract description 25
- 229920001600 hydrophobic polymer Polymers 0.000 claims abstract description 15
- 230000035508 accumulation Effects 0.000 claims abstract description 10
- 238000009825 accumulation Methods 0.000 claims abstract description 10
- 230000008961 swelling Effects 0.000 claims abstract description 6
- 239000012528 membrane Substances 0.000 claims abstract description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 20
- 229910052709 silver Inorganic materials 0.000 claims description 18
- 239000004332 silver Substances 0.000 claims description 18
- 230000000844 anti-bacterial effect Effects 0.000 claims description 15
- 230000029663 wound healing Effects 0.000 claims description 13
- 239000002245 particle Substances 0.000 claims description 12
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical group [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims description 12
- 239000000463 material Substances 0.000 claims description 10
- 239000004814 polyurethane Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 10
- 229920002635 polyurethane Polymers 0.000 claims description 9
- 239000011782 vitamin Substances 0.000 claims description 9
- 229930003231 vitamin Natural products 0.000 claims description 9
- 235000013343 vitamin Nutrition 0.000 claims description 9
- 229940088594 vitamin Drugs 0.000 claims description 9
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims description 7
- 230000010478 bone regeneration Effects 0.000 claims description 7
- 230000035876 healing Effects 0.000 claims description 6
- 239000002105 nanoparticle Substances 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 108090000623 proteins and genes Proteins 0.000 claims description 6
- 101800003838 Epidermal growth factor Proteins 0.000 claims description 5
- 229940116977 epidermal growth factor Drugs 0.000 claims description 5
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 230000000845 anti-microbial effect Effects 0.000 claims description 4
- 239000000017 hydrogel Substances 0.000 claims description 3
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- 229910001961 silver nitrate Inorganic materials 0.000 claims description 3
- YPNVIBVEFVRZPJ-UHFFFAOYSA-L silver sulfate Chemical compound [Ag+].[Ag+].[O-]S([O-])(=O)=O YPNVIBVEFVRZPJ-UHFFFAOYSA-L 0.000 claims description 3
- 230000010148 water-pollination Effects 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 229910000367 silver sulfate Inorganic materials 0.000 claims 1
- 239000007788 liquid Substances 0.000 abstract description 11
- 238000009987 spinning Methods 0.000 description 17
- -1 polyethylene terephthalate Polymers 0.000 description 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 8
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 5
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000002121 nanofiber Substances 0.000 description 4
- 229920002239 polyacrylonitrile Polymers 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 3
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 3
- 229940126864 fibroblast growth factor Drugs 0.000 description 3
- 208000014674 injury Diseases 0.000 description 3
- 239000011505 plaster Substances 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 229920002981 polyvinylidene fluoride Polymers 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000008733 trauma Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- OIFBSDVPJOWBCH-UHFFFAOYSA-N Diethyl carbonate Chemical compound CCOC(=O)OCC OIFBSDVPJOWBCH-UHFFFAOYSA-N 0.000 description 2
- KMTRUDSVKNLOMY-UHFFFAOYSA-N Ethylene carbonate Chemical compound O=C1OCCO1 KMTRUDSVKNLOMY-UHFFFAOYSA-N 0.000 description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
- 239000004952 Polyamide Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 239000004743 Polypropylene Substances 0.000 description 2
- 229910021607 Silver chloride Inorganic materials 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- JBTWLSYIZRCDFO-UHFFFAOYSA-N ethyl methyl carbonate Chemical compound CCOC(=O)OC JBTWLSYIZRCDFO-UHFFFAOYSA-N 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- SDLBJIZEEMKQKY-UHFFFAOYSA-M silver chlorate Chemical compound [Ag+].[O-]Cl(=O)=O SDLBJIZEEMKQKY-UHFFFAOYSA-M 0.000 description 2
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- VJGCZWVJDRIHNC-UHFFFAOYSA-N 1-fluoroprop-1-ene Chemical compound CC=CF VJGCZWVJDRIHNC-UHFFFAOYSA-N 0.000 description 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 229920008347 Cellulose acetate propionate Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000002033 PVDF binder Substances 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004697 Polyetherimide Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229940081735 acetylcellulose Drugs 0.000 description 1
- YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- HLKZFSVWBQSKKH-UHFFFAOYSA-N but-3-enoic acid;1-ethenylpyrrolidin-2-one Chemical compound OC(=O)CC=C.C=CN1CCCC1=O HLKZFSVWBQSKKH-UHFFFAOYSA-N 0.000 description 1
- SIXOAUAWLZKQKX-UHFFFAOYSA-N carbonic acid;prop-1-ene Chemical compound CC=C.OC(O)=O SIXOAUAWLZKQKX-UHFFFAOYSA-N 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 1
- ARQRPTNYUOLOGH-UHFFFAOYSA-N chcl3 chloroform Chemical compound ClC(Cl)Cl.ClC(Cl)Cl ARQRPTNYUOLOGH-UHFFFAOYSA-N 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 150000001983 dialkylethers Chemical class 0.000 description 1
- 230000009429 distress Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- XVVLAOSRANDVDB-UHFFFAOYSA-N formic acid Chemical compound OC=O.OC=O XVVLAOSRANDVDB-UHFFFAOYSA-N 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229920001643 poly(ether ketone) Polymers 0.000 description 1
- 229920003207 poly(ethylene-2,6-naphthalate) Polymers 0.000 description 1
- 229920002627 poly(phosphazenes) Polymers 0.000 description 1
- 229920002285 poly(styrene-co-acrylonitrile) Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920001601 polyetherimide Polymers 0.000 description 1
- 239000011112 polyethylene naphthalate Substances 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- YGSFNCRAZOCNDJ-UHFFFAOYSA-N propan-2-one Chemical compound CC(C)=O.CC(C)=O YGSFNCRAZOCNDJ-UHFFFAOYSA-N 0.000 description 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 1
- 229940032159 propylene carbonate Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01008—Non-adhesive bandages or dressings characterised by the material
- A61F13/01017—Non-adhesive bandages or dressings characterised by the material synthetic, e.g. polymer based
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
- A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/38—Silver; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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Abstract
本发明涉及干式贴，其特征在于，包括：创伤膜，由含有因从伤口分泌的渗出物而溶胀的亲水性高分子、疏水性高分子及通过上述亲水性高分子的溶胀来得以释放且难以以液体状态储存的干式伤口愈合剂的纤维堆积而成；以及第一离型部件，作为供上述纤维堆积的支撑体，能够从上述创伤膜分离。
Description
技术领域
本发明涉及干式贴，更详细地涉及如下的干式贴：可通过使难以以液体状态储存的伤口愈合剂包含在干式的纤维中，来长期储存并可将伤口愈合能力最大化。
背景技术
通常，产生伤口先进行消毒后，根据在伤口中产生的渗出物的量，使伤口治疗用创伤贴充分覆盖伤口的表面后，利用医疗用胶带进行固定。
创伤贴具有保护伤口、吸收渗出物、促进止血、支撑伤口的作用，通过覆盖作为由烧伤、创伤、褥疮及外伤引起的皮肤缺损部位的伤口表面，来提高愈合速度。
韩国公开专利公报第2010-0021108号公开了一种抗菌敷料层叠体，其中，包括：含有银纳米粒子的纳米纤维部件；渗出物吸收部件，层叠于上述纳米纤维部件的上部；以及盖部件，由半渗透膜形成，并层叠于上述渗出物吸收部件的上部，上述抗菌敷料层叠体的特征在于，上述含有银纳米粒子的纳米纤维部件由纳米纤维形成，利用包含形成纤维的高分子和银(Ag)金属盐的纺丝溶液进行电纺丝，来制造成纤维直径小于1μm的网状形态。
韩国公开专利公报第2010-0021108号中，利用纤维实现创伤敷料，但是仅具有抗菌特性及渗出物吸收功能，从而存在伤口愈合速度缓慢的缺点。
因此，当前需要开发用于提供最佳愈合环境的创伤贴及可赋予新概念的功能的创伤贴。
发明内容
技术问题
本发明鉴于如上所述的问题而提出，其目的在于，提供可长期储存难以长时间以液体状态储存的伤口愈合剂的干式贴。
本发明的另一目的在于，提供干式贴，上述干式贴通过从伤口分泌的渗出物引起的亲水性高分子的溶胀，来向伤口区域释放伤口愈合剂，从而可提高伤口愈合能力。
解决问题的方案
用于实现上述目的的本发明一实施例的干式贴的特征在于，包括：创伤膜，由含有因从伤口分泌的渗出物而溶胀的亲水性高分子、疏水性高分子及通过上述亲水性高分子的溶胀来得以释放(release)的干式伤口愈合剂的纤维堆积而成；以及第一离型部件，作为供上述纤维堆积的支撑体，能够从上述创伤膜分离。
上述干式伤口愈合剂可以为维生素、酶、蛋白质、肽-维生素C衍生物中的一种。
上述第一离型部件可配置于上述创伤膜的下部面，本发明的干式贴还可包括配置在上述创伤膜的上部面的第二离型部件。
并且，上述纤维还可含有表皮生长因子(EGF，Epidermal Growth Factor)、成纤维细胞生长因子(FGF，Fibroblast Growth Factor)、用于愈合的蛋白质及抗菌物质中的至少一种伤口治疗剂。
并且，上述抗菌物质可以为银纳米物质、银粒子及天然抗菌物质中的一种。此时，上述银纳米物质可以为硝酸银(AgNO3)、硫酸银(Ag2SO4)、氯化银(AgCl)中的一种。
并且，上述银粒子的大小可小于上述纤维的直径。
另一方面，上述亲水性高分子可包含聚氨酯(PU，polyurethane)或者水凝胶。
并且，上述第一离型部件可以为离型膜、离型纸及无纺布中的一种。
并且，上述纤维的纤维直径可以为0.2～1.5μm。
能够以3：7至9：1范围的重量比混合上述亲水性高分子和疏水性高分子，相对于高分子的总重量，可包含0.1重量百分比至15重量百分比范围的上述干式伤口愈合剂。
并且，上述干式伤口愈合剂可包含维生素，相对于高分子的总重量，可包含5重量百分比至10重量百分比范围的上述维生素。
上述干式伤口愈合剂可通过与亲水性高分子链相结合或包含于亲水性高分子链，来限制在纤维内部，当亲水性高分子吸收渗出物的水分而溶胀时，可释放干式伤口愈合剂的粒子。
上述创伤膜至少由两层构成，随着靠近伤口的层，亲水性高分子的含量增加，使得迅速因渗出物而溶胀。
发明的效果
根据本发明，以干式使难以长时间以液体状态储存的伤口愈合剂限制在纤维，从而具有可长期储存在液态中分解的维生素、酶、蛋白质、肽-维生素C衍生物等的伤口愈合剂的优点。
根据本发明，具有如下优点：通过由伤口分泌的渗出物引起的亲水性高分子的溶胀，来向伤口区域释放伤口愈合剂，从而可将伤口愈合最大化。
根据本发明，亲水性高分子因渗出物而溶胀，来缓慢地释放抗菌物质，从而具有如下优点：通过减少与伤口相接触的抗菌物质量，来减少痛症，并可提高在伤口面中的抗菌特性。
附图说明
图1为本发明的干式贴的两层结构的剖视图。
图2为本发明的干式贴的三层结构的剖视图。
图3为用于说明用于制造本发明的创伤膜的电纺丝装置的示意图。
具体实施方式
以下，参照附图对用于实施本发明的具体内容进行说明。
参照图1，根据本发明的干式贴100包括：创伤膜110，由含有因从伤口分泌的渗出物而溶胀的亲水性高分子、疏水性高分子及通过上述亲水性高分子的溶胀来得以释放(release)且难以以液体状态储存的干式伤口愈合剂的纤维210(参照图3)堆积而成；以及第一离型部件120，作为供上述纤维堆积的支撑体，可从上述创伤膜分离。
本发明的干式贴100可根据含有什么种类/用途的干式伤口愈合剂，用作创伤贴、特应性贴等多种愈合贴。
在本发明中可制造由创伤膜110及离型部件120形成的两层结构的干式贴100，如图2所示，可利用第一离型部件121、创伤膜110及第二离型部件122的三层结构实现干式贴101。
例如，上述干式伤口愈合剂为维生素、酶、蛋白质、肽-维生素C衍生物等伤口愈合剂，由于它们在液态下分解，因此难以以液体状态长时间储存。在上述情况下，在形成上述干式伤口愈合剂的纤维中还可包含通常的伤口愈合剂。
本发明具有如下优点：使在构成干式贴100的创伤膜110的纤维内部以干式含有难以以液体状态储存的伤口愈合剂，从而以限制在纤维内部的干式状态长期储存，当亲水性高分子因渗出物而溶胀时，释放干式伤口愈合剂，并向伤口传递，从而可取得迅速的伤口愈合效果。
亲水性高分子作为通过从伤口分泌的渗出物中在内部含有大量的水分来具有溶胀特性的高分子，可使用聚氨酯(polyurethane)、水凝胶等。
在本发明的干式贴中，干式伤口愈合剂与亲水性高分子一同包含于纤维内部。其中，干式伤口愈合剂作为大小为数纳米～数十纳米的粒子，通过与亲水性高分子链相结合或包含于亲水性高分子链，来限制在纤维内部，若亲水性高分子吸收渗出物的水分，则链的间隔拉开，而产生溶胀现象，因而干式伤口愈合剂的粒子得以释放，从而向伤口传递干式伤口愈合剂并治愈伤口。
另一方面，肽-维生素C衍生物作为结合有维生素C的肽，具体地，由维生素C与作为由肽键相连接的10个以下的氨基酸形成的聚合物的肽相连接而成。
肽-维生素C衍生物具有少量的肽键结构，从而容易渗透于伤口区域的皮肤。
因而，在本发明的创伤膜110的纤维与肽-维生素C衍生物一同含有伤口治疗剂的情况下，当亲水性高分子因渗出物而溶胀时，一同释放包含于纤维的肽-维生素C衍生物及伤口治疗剂。
此时，肽-维生素C衍生物的渗透于伤口皮肤的能力优秀，从而促进伤口治疗剂渗透于伤口皮肤，由此可快速恢复伤口。
并且，本发明的构成创伤膜110的纤维还可含有生长因子(GF)，如表皮生长因子(EGF、Epidermal Growth Factor)、成纤维细胞生长因子(FGF、Fibroblast GrowthFactor)等；以及伤口治疗剂，如用于愈合的蛋白质、抗菌物质等。
优选地，抗菌物质为银纳米物质、银粒子及壳聚糖等的天然抗菌物质中的一种。此时，银纳米物质为银(Ag，silver)金属盐，如硝酸银(AgNO3)、硫酸银(Ag2SO4)、氯化银(AgCl)等。
相对于高分子的总重量，可包含1重量百分比至10重量百分比范围的上述抗菌物质，若相对于高分子的总重量，包含小于1重量百分比的上述抗菌物质，则含量少，从而难以表现性能，在大于10重量百分比的情况下，存在如下问题：准备纺丝溶液进行电纺丝时，无法实现纺丝，并且即使含量增加，抗菌性能也不再增加且费用也增加。
并且，作为银粒子可选择使用大小小于纤维的直径的银粒子，使得银粒子分散于纤维。
因此，本发明的干式贴100具有如下优点：在创伤膜110的纤维含有抗菌物质的情况下，当亲水性高分子因渗出物而缓慢溶胀时，通过逐渐释放抗菌物质，来使少量的抗菌物质与伤口相接触，从而可减少痛症。
即，在普通干式贴的情况下，在干式贴涂敷有银，在上述银涂敷面中释放过多的银，患者可感觉到很大的痛症。相反地，在本发明的干式贴中，通过缓慢地释放少量的抗菌物质，来与伤口相接触，从而缓解患者可感觉到的痛症。
并且，创伤膜110由纤维堆积而成，因而可实现具有形成于纤维之间的多个微细气孔的结构。
离型部件110可使用由聚对苯二甲酸乙二醇酯(PET)、聚丙稀(PP)等形成的离型膜、离型纸及无纺布等。
并且，在本发明中，能够以至少两层的结构实现创伤膜110，此时，可不同地设计各层的纤维的纤维直径或气孔大小。并且，能够以如下方式构成：随靠近伤口的层，亲水性高分子的含量增多，使得迅速因渗出物而溶胀。
图3为用于说明用于制造本发明的创伤膜的电纺丝装置的示意图。
参照图3，在用于制造本发明的创伤膜的电纺丝装置中，用于供给经搅拌的纺丝溶液的搅拌罐20与纺丝喷嘴40相连接，在与纺丝喷嘴40隔开的下部配置有以规定速度移动的传送带形状的折叠式收集器50，纺丝喷嘴40与高压发生器相连接。
其中，利用搅拌器30通过混合亲水性高分子、疏水性高分子、干式伤口愈合剂及溶剂来制备纺丝溶液。此时，可使用不在搅拌器30中混合而在投入于电纺丝设备之前预先混合的纺丝溶液。
然后，若向收集器50与纺丝喷嘴40之间输入高电压静电力，则在纺丝喷嘴40中将纺丝溶液制成超细纤维210来向收集器50纺丝，在收集器50堆积有多个纤维210并形成使用于干式贴的创伤膜200的纤维网。
更具体地，从纺丝喷嘴40排出的纺丝溶液经过借助高压发生器而带电的纺丝喷嘴40并作为纤维210来排出，之后纤维210依次层叠于以规定速度移动的传输带形状的折叠式收集器50的上部，由此形成创伤膜200用纤维网。
即，本发明的创伤膜由以纤维堆积而成的具有多个气孔的纤维网形成，上述纤维通过对利用混合亲水性高分子、疏水性高分子、干式伤口愈合剂及溶剂的纺丝溶液进行电纺丝来取得。
在形成上述纤维网的纤维均包含亲水性高分子、疏水性高分子及干式伤口愈合剂的情况下，以3：7至9：1范围的重量比混合亲水性高分子和疏水性高分子，相对于高分子的总重量，可包含0.1重量百分比至15重量百分比范围的干式伤口愈合剂。尤其，优选地，相对于高分子的总重量，包含5重量百分比至10重量百分比的维生素。
当混合上述亲水性高分子和疏水性高分子时，在包含小于30重量百分比的水溶性高分子的情况下，因渗出物而溶胀时，无法实现亲水化，在大于90重量百分比的情况下，当为了形成纤维网结构的创伤膜110而利用纺丝溶液进行电纺丝时，存在无法形成网的问题。
并且，当相对于高分子的总重量，包含小于0.1重量百分比的上述干式伤口愈合剂时，因含量少而难以表现性能，在大于15重量百分比的情况下，准备纺丝溶液进行电纺丝时，存在无法实现纺丝且费用增加的问题。
由于使用于本发明的干式贴的创伤膜在伤口愈合时可洗脱高分子，因此不使用水溶性高分子，而使用亲水性高分子。
但是，在使用聚氨酯(PU)来作为亲水性高分子的情况下，聚氨酯的伸缩性好，因此为了抑制伸缩性，需要包含弹性相对低且属于非水溶性的疏水性的高分子，例如聚偏氟乙烯(PVdF)。
在本发明中，创伤膜的纤维的纤维直径可以为0.2～1.5μm且气孔大小可以为0.2～1.5μm。并且，创伤膜的厚度可以为5～20μm，克重可以为5～30gsm。
在创伤膜110的厚度小于5μm且克重小于5gsm的情况下，由于强度低，从而难以进行处理，在形状保持层121的厚度大于20μm且克重大于30gsm的情况下，存在丧失透明性且制造费用增加的问题。
另一方面，在创伤膜110中，形成纤维膜的纤维具有多个微细气孔，因而微细气孔吸收包含于渗出物的水分，这种状态使得漫反射去除，从而使膜显得透明，若包含于渗出物的水分处于干燥的状态，则变成白色或除了白色之外的其他颜色，并处于不透明状态。
因此，在伤口部分附着创伤膜110并固定的情况下，观察到从透明状态变成不透明状态，即使不打开附着的创伤膜110也可预测伤口部分的状态，由此可预测创伤膜110的更换时期。
疏水性高分子可进行电纺丝，用于即使亲水性高分子因渗出物而溶胀，来释放伤口愈合剂，也保持创伤膜110的结构。并且，疏水性高分子只要是可通过电纺丝形成纤维的树脂，就并不做特别限制，还可使用天然高分子。
作为可使用的疏水性高分子，例如，可例举聚偏氟乙烯(PVdF)、聚(偏氟乙烯共六氟丙烯)、全氟聚合物、聚氯乙烯、聚偏二氯乙烯或它们的共聚物、包括聚乙二醇二烷基醚及聚乙二醇二烷基酯的聚乙二醇衍生物、包括聚(氧亚甲基-低聚-氧乙基)、聚环氧乙烷及聚环氧丙烷的多氧化物、包括聚乙酸乙烯酯、聚(乙烯吡咯烷酮-乙酸乙烯酯)、聚苯乙烯及聚苯乙烯丙烯腈共聚物、聚丙烯腈(PAN)及聚丙烯腈甲基丙烯酸甲酯共聚物的聚丙烯腈共聚物、聚甲基丙烯酸甲酯、聚甲基丙烯酸甲酯共聚物或它们的混合物。
并且，作为可使用的疏水性高分子有芳香族聚酯，如聚酰胺、聚酰亚胺、聚酰胺酰亚胺、聚(间苯二甲酰间苯二胺)、聚砜、聚醚酮、聚醚酰亚胺、聚对苯二甲酸乙二醇酯、聚对苯二甲酸丙二醇酯、聚萘二甲酸乙二醇酯等；聚磷腈类，如聚四氟乙烯、聚二苯氧基磷腈，聚(双(2-(2-甲氧基乙氧基)磷腈))等；聚氨酯共聚物(疏水性)，包括聚氨酯及聚醚氨基甲酸乙酯；乙酸纤维素；乙酸丁酸纤维素；乙酸丙酸纤维素等。
作为溶剂可使用选自由N,N-二甲基乙酰胺(DMAc，N,N-Dimeth yl acetoamide)、N,N-二甲基甲酰胺(DMF，N,N-Dimethylformamide)、N-甲基吡咯烷酮NMP(NMP，N-methyl-2-pyrrolidinone)、二甲基亚砜(DMSO，dimethyl sulfoxide)、四氢呋喃(THF，tetra-hydrofuran)、碳酸乙烯酯(EC，ethylene carbonate)、碳酸二乙酯(DEC，diethylcarbonate)、碳酸二甲酯(DMC，dimethyl carbonate)、碳酸甲乙酯(EMC，ethyl methylcarbonate)、碳酸丙烯酯(PC，propylene carb onate)、水、乙酸(acetic acid)、甲酸(formic acid)、氯仿(Chlo roform)、二氯甲烷(dichloromethane)、丙酮(acetone)及异丙醇(isopropylalchol)组成的组中的一种以上。
以上，通过例举特定的优选实施例来对本发明进行图示出及说明，但是本发明并不局限于上述的实施例，在不脱离本发明的精神的范围下，由本发明所属技术领域的普通技术人员可进行多种变更和修改。
产业上的可利用性
本发明可通过在干式的纤维含有难以以液体状态储存的伤口愈合剂，来适用于可长时间储存且可使伤口愈合能力最大化的干式贴。
Claims (15)
1.一种干式贴，其特征在于，包括：
创伤膜，由含有因从伤口分泌的渗出物而溶胀的亲水性高分子、疏水性高分子及通过上述亲水性高分子的溶胀来得以释放的干式伤口愈合剂的纤维堆积而成；以及
第一离型部件，作为供上述纤维堆积的支撑体，能够从上述创伤膜分离。
2.根据权利要求1所述的干式贴，其特征在于，上述干式伤口愈合剂为维生素、酶、蛋白质及肽-维生素C衍生物中的一种。
3.根据权利要求1所述的干式贴，其特征在于，上述第一离型部件配置于上述创伤膜的下部面，上述干式贴还包括配置在上述创伤膜的上部面的第二离型部件。
4.根据权利要求1所述的干式贴，其特征在于，上述纤维还含有表皮生长因子、成纤维细胞生长因子、用于愈合的蛋白质及抗菌物质中的至少一种伤口治疗剂。
5.根据权利要求4所述的干式贴，其特征在于，上述抗菌物质为银纳米物质、银粒子及天然抗菌物质中的一种。
6.根据权利要求5所述的干式贴，其特征在于，上述银纳米物质为硝酸银、硫酸银及氯化银中的一种。
7.根据权利要求5所述的干式贴，其特征在于，上述银粒子的大小小于上述纤维的直径。
8.根据权利要求1所述的干式贴，其特征在于，上述亲水性高分子包含聚氨酯及水凝胶中的一种。
9.根据权利要求1所述的干式贴，其特征在于，上述第一离型部件为离型膜、离型纸及无纺布中的一种。
10.根据权利要求1所述的干式贴，其特征在于，上述纤维的纤维直径为0.2～1.5μm。
11.根据权利要求1所述的干式贴，其特征在于，以3：7至9：1范围的重量比混合上述亲水性高分子和疏水性高分子。
12.根据权利要求11所述的干式贴，其特征在于，相对于高分子的总重量，包含0.1重量百分比至15重量百分比范围的上述干式伤口愈合剂。
13.根据权利要求12所述的干式贴，其特征在于，
上述干式伤口愈合剂包含维生素，
相对于高分子的总重量，包含5重量百分比至10重量百分比范围的上述维生素。
14.根据权利要求1所述的干式贴，其特征在于，上述干式伤口愈合剂通过与亲水性高分子链相结合或包含于亲水性高分子链，来限制在纤维内部，当亲水性高分子吸收渗出物的水分而溶胀时，释放干式伤口愈合剂的粒子。
15.根据权利要求1所述的干式贴，其特征在于，上述创伤膜至少由两层构成，随着靠近伤口的层，亲水性高分子的含量增加，使得迅速因渗出物而溶胀。
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| Publication number | Priority date | Publication date | Assignee | Title |
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Family Cites Families (13)
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