CN108042610A - Safety plantation dental restortion liquid and preparation method thereof - Google Patents
Safety plantation dental restortion liquid and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of safety plantation dental restortion liquid and preparation method thereof, and the safety plantation dental restortion liquid includes the raw material of following weight parts：60 80 parts of water, 20 30 parts of Chinese medicine extract, 10 20 parts of pearl extracting solution, 15 parts of synergist of reparation, 5 10 parts of honey.Safety plantation dental restortion liquid of the invention and preparation method thereof, obtained safety plantation dental restortion liquid energy enough effectively reduction postoperative infection and swelling, wound is reduced to minimum degree, reduce the generation of inflammation, accelerate the reparation of tooth-implanting, tooth-implanting success rate is improved, extends the service life of tooth-implanting and natural teeth.
Description
Technical field
The present invention relates to oral care techniques fields, and in particular to a kind of safety plantation dental restortion liquid and preparation method thereof.
Background technology
Tooth-implanting refer to it is a kind of based on the substructure being implanted into bone tissue to support, maintenance top dental case
Agomphosis repair mode.It includes the support planting body (dental implant) of lower part and the dental case (dental on top
Prosthesis, implant-supported) two parts.Planting body is made using artificial material (such as metal, ceramics) in it
(general similar root form) (typically upper lower jaw) and obtains the firm maintenance branch of bone tissue in underwent operative method implanting tissue
It holds, connects the dental case for supporting top with mode by special device.
Cause tooth or dentition defect due to periodontosis, dental caries, wound etc., tooth-implanting is that benefit missing tooth is state-of-the-art
Method.By years of researches and practice, tooth-implanting technology is highly developed, but since many factors influence, tooth-implanting is local
The main reason for being susceptible to inflammatory reaction, influencing tooth-implanting and heal with bone tissue, and absorbed as bone tissue, finally leads
Cause tooth-implanting failure.One major reason of tooth-implanting failure is peri-implantitiss, and peri-implantitiss refer to betide
It forms synosteosis and starts the inflammatory reaction of Peri-implant tissues to function.Peri-implantitiss belong in broad sense
Periodontitis, initial stage periodontal soft tissue redness distending pain, periodontal bag formation causes tooth-implanting is horizontal lose, loosen, ultimately results in kind
Plant tooth failure.
Therefore tooth-implanting restoration care is extremely important.This invention address that providing a kind of safety plantation dental restortion liquid, reduce
Wound is reduced to minimum degree by postoperative infection and swelling, reduces the generation of inflammation, improves tooth-implanting success rate.
The content of the invention
For above-mentioned deficiency in the prior art, the technical problems to be solved by the invention are to provide a kind of safe kind
Dental restortion liquid and preparation method thereof is planted, obtained safety plantation dental restortion liquid energy is enough effectively to reduce postoperative infection and swelling, will create
Wound is reduced to minimum degree, reduces the generation of inflammation, accelerates the reparation of tooth-implanting, improves tooth-implanting success rate, extends tooth-implanting
With the service life of natural teeth.
The present invention seeks to what is be achieved through the following technical solutions：
A kind of safety plantation dental restortion liquid, the raw material including following weight parts：60-80 parts of water, Chinese medicine extract 20-30
Part, 10-20 parts of pearl extracting solution repair 1-5 parts of synergist, 5-10 parts of honey.
A kind of safety plantation dental restortion liquid, the raw material including following weight parts：60-80 parts of Chinese medical stone water, Chinese medicine extract
20-30 parts, 10-20 parts of pearl extracting solution, repair 1-5 parts of synergist, 5-10 parts of honey.
The preparation method of the Chinese medicine extract comprises the following steps：
(1) by 20-30 parts of honeysuckle, 20-30 parts of Chinese gall, 5-10 parts of Asian puccoon, 5-10 parts of radix scutellariae, 1-5 parts of the root of Dahurain angelica, difference
When 60-80 DEG C of dry 6-10 is small, it is uniformly mixed after crushing, obtains traditional Chinese medicine powder；
(2) water of 8-12 times of traditional Chinese medicine powder quality is added in traditional Chinese medicine powder, 50-60 minutes is kept the temperature at 90-98 DEG C, is filtered with 300 mesh
Cloth filters, and collects filtrate A；The water of 5-10 times of traditional Chinese medicine powder quality is added in the dregs of a decoction, 40-50 minutes are kept the temperature at 90-98 DEG C, with
300 mesh filter-cloth filtering wastes obtain liquor B, merge filtrate twice, obtain Chinese medicine extract.
The preparation method of the Chinese medical stone water comprises the following steps：
(1) medical stone surface is cleaned, dries surface moisture, crushed, crossed 100 mesh sieves, obtain medical stone powder；
(2) medical stone powder and water are pressed into solid-to-liquid ratio 1g：(10-20) mL mix, 20-30 DEG C stand 12-24 it is small when after,
60-80 DEG C with 100-300 revs/min stirring 2-6 it is small when, obtain medical stone mixed liquor；
(3) medical stone mixed liquor with 4000-8000 revs/min is centrifuged 10-20 minutes, supernatant is taken, with 0.22 μ of Kong Jingwei
The membrane filtration of m, obtains Chinese medical stone water.
Preferably, the preparation method of the Chinese medical stone water comprises the following steps：
(1) medical stone surface is cleaned, dries surface moisture, crushed, crossed 100 mesh sieves, obtain medical stone powder；
(2) medical stone powder and water are pressed into solid-to-liquid ratio 1g：(10-20) mL mix, 20-30 DEG C stand 12-24 it is small when after, use
It is 5.5-6.5 that acid solution, which adjusts pH, when 60-80 DEG C small with 100-300 revs/min of stirring 2-6, obtains medical stone mixed liquor；
(3) medical stone mixed liquor with 4000-8000 revs/min is centrifuged 10-20 minutes, supernatant is taken, with 0.22 μ of Kong Jingwei
The membrane filtration of m, obtains Chinese medical stone water.
The preparation method of the pearl extracting solution comprises the following steps：
(1) pearl is cleaned, impurity elimination, crushes, obtain thick pearl powder；
(2) it will be sanded in the grinding cylinder of dispersion machine and add in a diameter of 0.1mm zirconia balls, added in feed paddle cylinder
Ethyl alcohol starts grinder, while adds in thick pearl powder, and the solid-to-liquid ratio of thick pearl powder and ethyl alcohol is 1g：(15-25) mL grinds 65-
75 minutes, pearl powder slurry is obtained, pearl powder slurry is centrifuged 10-20 minutes with 3000-5000 revs/min, by solid in temperature
When 60-70 DEG C of dry 6-8 is small, nano-glass pearl powder is obtained；
(3) nano-glass pearl powder and water are pressed into solid-to-liquid ratio 1g：(20-40) mL is mixed, and adds in mixed enzyme, the mixed enzyme
Addition is the 0.1-0.5% of nano-glass pearl powder quality, when 50-60 DEG C small with 100-300 revs/min of stirring 2-6, in 95-
100 DEG C keep the temperature 3-5 minutes, obtain enzymolysis liquid；
(4) enzymolysis liquid with 3000-5000 revs/min is centrifuged 10-20 minutes, supernatant is taken, with 0.22 μm of films of Kong Jingwei
Filtering, obtains pearl extracting solution.
The mixed enzyme is mixed by 50-70wt% neutral proteinases and 30-50wt% papains.
The acid solution is the aqueous solutions of organic acids that mass fraction is 5-10%, and the organic acid is citric acid, tartaric acid, breast
One kind in acid.
Preferably, the organic acid is lactic acid.
The reparation synergist is polysaccharides and/or soybean polyoses.
Preferably, the mixture for repairing synergist polysaccharides and soybean polyoses, the polysaccharides and soybean are more
The mass ratio of sugar is (2-6)：1.
A kind of preparation method of safety plantation dental restortion liquid, comprises the following steps：By Chinese medicine extract, pearl extracting solution,
Reparation synergist, honey are added in Chinese medical stone water, are stirred 30-60 minutes with 200-400 revs/min, are obtained safe tooth-implanting and repair
Multiple liquid.
Safety plantation dental restortion liquid of the present invention, can both contain and gargle, and can also take or smear, before and after dental implant surgical
It can use.
Safety of the invention plants dental restortion liquid and preparation method thereof, the obtained enough effectively reductions of safety plantation dental restortion liquid energy
Wound is reduced to minimum degree by postoperative infection and swelling, reduces the generation of inflammation, accelerates the reparation of tooth-implanting, improves plantation
Tooth success rate extends the service life of tooth-implanting and natural teeth.
Specific embodiment
In the present invention, if not refering in particular to, all devices and raw material is commercially available or the industry is common are following
Method in embodiment is this field conventional method unless otherwise instructed.
Pearl, the pearl that Shaoxing, Zhejiang Province city Fu Quan towns pearl farm provides are hydriopsis cumingii (Hyriopsis
Cumingii) the substance of stimulated secretion.
Medical stone, the food-grade medical stone that Lingshou County Jin Yuan mineral products processings factory provides.
Honeysuckle, Classification system：Lonicera Japonica are caprifoliaceae plant honeysuckle Lonicera japonica
Thunb. dry flower or with the flower just opened, nature and flavor：It is sweet, it trembles with fear.Channel tropism：Return lung, the heart, stomach.Effect：It is clearing heat and detoxicating, it is cool to dissipate
Wind-heat.It cures mainly：For carbuncle swells furunculosis larynx numbness, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating.
Chinese gall, Classification system：Rhus chinensis Mill. are Anacardiaceae plant Chinese sumac Rhus chinensis
Mill., potanin sumac Rhus potaninii Maxim. or redpunjab sumac root Rhus punjabensisStew.var.sinica
(Diels) insect gall is mainly parasitic by melaphis chinensis Baker Melaphis chinensis (Bell) Baker on Rehd.et Wils. leaves
And it is formed.Nature and flavor：It is sour, puckery, it trembles with fear.Channel tropism：Return lung, large intestine, kidney channel.Effect：It astringes the lung fall fire, relieving diarrhea with astringents, arrest sweating hemostasis, hygroscopic
Sore.It cures mainly：For chronic cough of deficiency lung, lung feverish cough, protracted dysentery and diarrhea, night sweat quenches one's thirst, hemorrhoid blood of having blood in stool, traumatic hemorrhage, carbuncle swells sore
Poison, skin moisture fester.
Asian puccoon, Classification system：Lithospermum erythrorhizon Sieb.et Zucc. are that comfrey is new
The dry root of boundary Asian puccoon Arnebia euchroma (Royle) Johnst. or arnebia guttata Bunge Arnebia guttata Bunge.
Nature and flavor：It is sweet, salty, it trembles with fear.Channel tropism：Converge to heart and liver channels.Effect：Cool blood, promoting blood circulation, promoting eruption of detoxifying.It cures mainly：For blood-heat and toxin exuberance, class's rash is purple
It is black, measles without adequate eruption, sore, eczema, scald.
Radix scutellariae, Classification system：Scutellaria baicalensis Georgi are labiate radix scutellariae
The dry root of Scutellaria baicalensis Georgi, nature and flavor：Hardship is trembled with fear.Channel tropism：Return lung, courage, spleen, large intestine, small intestine
Through.Effect：Heat-clearing and damp-drying drug rushes down people's removing toxic substances, hemostasis, tocolysis.It cures mainly：For damp-warm syndrome, heat temperature chest tightness and emesis, damp and hot feeling of fullness, rush down dysentery,
Jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, fetal irritability.
The root of Dahurain angelica, Classification system：Angelica dahurica(Fisch.ex Hoffm.)Benth.et Hook.f.ex
Franch.et Sav are samphire the root of Dahurain angelica Angelica dahurica (Fisch.exHOffm.) Benth.et
Or Radix angelicae dahuricae Angelica dahurica (Fisch.ex Hoffm.) Benth.et Hook.f.
The dry root of Hook.f.var.formosana (Boiss.) Shan et Yuan.Nature and flavor：It is acrid in flavour and warm in nature.Channel tropism：Return stomach, large intestine, lung
Through.Effect：Relieve heat dehumidifies, sensible analgesic, detumescence and apocenosis.It cures mainly：For cold headache, pain in the supra-orbital bone is had a stuffy nose, nasosinusitis, toothache,
Leukorrhea, sore swell and ache curative.
Papain, using the food-grade papain of Nanjing Dong Henghua roads biotechnology limit company production, enzyme activity
30000U/g。
Neutral proteinase, using the food-grade neutral protease of Nanjing Dong Henghua roads biotechnology limit company production, enzyme activity
30000U/g。
Soybean polyoses, converge the offer of bioengineering Co., Ltd in Jiangsu thousand, food-grade.
Polysaccharides, Lanzhou water Lai Si bio tech ltd provide, food-grade
Citric acid, No. CAS：77-92-9, the food-grade anhydrous citric acid that Weifang Ensign Industry Co., Ltd, provides.
Tartaric acid, No. CAS：133-37-9, the imperial chemical industry of Hangzhou Linan gold have the food-grade DL- winestones that new company produces
Acid.
Lactic acid, No. CAS：50-21-5, the food grade lactic acid of Shandong bio tech ltd of Parkson production.
Honey, the acacia honey that Mengyin County Yongxing bee raising Specialty Co-operative Organization provides.
Dispersion machine is sanded, using vertical pair of the model KLLN of excitability rice engineering equipment Co., Ltd of section of Shenzhen production
Dispersion machine is sanded in axis nano ceramics.
Ethyl alcohol, using absolute ethyl alcohol in embodiment, scientific and technological (Jiangsu) Co., Ltd of China's chemistry provides forever.
Antiphlogistic effects are tested：SPF grades of healthy kunming mices 150,20 ± 2g of weight, half male and half female animal feeding room temperature
At 20-25 DEG C °, relative humidity control keeps cleaning in 50-60%, well-ventilated, artificial light 12h, all cage tools for control.It is small
Mouse free water is fed, and is adapted to 3 days in experimental situation, 12h is deprived of food but not water before experiment.
Mouse is randomly divided into 10 groups, every group 15, i.e. control group and experimental group (embodiment 1-7 and comparative example 1-2).It is real
The safety plantation dental restortion liquid that group is obtained according to the 0.1mL/10g gavage present invention is tested, once a day, continuous gavage 5 days, control group
Gavage normal saline, after last dose 2h, each 30 μ L dimethylbenzene proinflammatory agent (Chongqing Chuan Dong chemical industry of mouse auris dextra two sided coatings
Production), left ear is not dealt with to be compareed for normal ear.After causing inflammation 30min, cervical dislocation puts to death mouse, and two are cut along auricle baseline
Ear removes auricle, in weighing respectively on assay balance, by following public affairs at the same position of two ears respectively with diameter 8mm card punch
Formula calculates auricle edema inhibiting rate.
Statistical analysis is carried out after mouse ear corridor swelling test data, the results showed that P ＜ 0.05, difference have statistics
Learn meaning.
The bacteriostasis property of safety plantation dental restortion liquid to being obtained in embodiment is tested, with reference in GB15797-2002
The method of appendix C carries out, and test strain is Candida albicans (ATCC 10231) and staphylococcus aureus (ATCC 6538).
Embodiment 1
Safety plantation dental restortion liquid raw material (parts by weight)：70 parts of water, 25 parts of Chinese medicine extract, are repaiied 15 parts of pearl extracting solution
Multiple 2 parts of synergist, 8 parts of honey.
The preparation method of the Chinese medicine extract comprises the following steps：
(1) it is small in 70 DEG C of dryings 8 respectively by 25 parts of honeysuckle, 25 parts of Chinese gall, 8 parts of Asian puccoon, 8 parts of radix scutellariae, 3 parts of the root of Dahurain angelica
When, 80 mesh sieves are smashed it through, is uniformly mixed, obtains traditional Chinese medicine powder；
(2) water of 10 times of traditional Chinese medicine powder quality is added in traditional Chinese medicine powder, 55 minutes are kept the temperature at 95 DEG C, with 300 mesh filter-cloth filterings, is received
Collect filtrate A；The water of 8 times of traditional Chinese medicine powder quality is added in the dregs of a decoction, 45 minutes is kept the temperature at 95 DEG C, with 300 mesh filter-cloth filtering wastes, obtains
To liquor B, merge filtrate twice, obtain Chinese medicine extract.
The preparation method of the pearl extracting solution comprises the following steps：
(1) pearl is cleaned, impurity elimination, crushes, cross 80 mesh sieves, obtain thick pearl powder；
(2) it will be sanded in the grinding cylinder of dispersion machine and add in a diameter of 0.1mm zirconia balls, added in feed paddle cylinder
Ethyl alcohol, starts grinder, 1800 revs/min, feed pressure 0.35kPa of engine speed, while add in thick pearl powder, thick pearl powder and
The solid-to-liquid ratio of ethyl alcohol is 1g：The mass ratio 1 of 20mL, thick pearl powder and zirconia ball：30, it grinds 70 minutes, obtains pearl slurry
Pearl powder slurry with 4000 revs/min is centrifuged 15 minutes, by solid when 65 DEG C of dryings 7 of temperature are small, obtains nanometer level pearl by material
Powder；
(3) nano-glass pearl powder and water are pressed into solid-to-liquid ratio 1g：30mL is mixed, and adds in mixed enzyme, the addition of the mixed enzyme
Amount is the 0.3% of nano-glass pearl powder quality, when 55 DEG C small with 200 revs/min of stirrings 4, keep the temperature 4 minutes at 98 DEG C, obtains enzyme
Solve liquid；
(4) enzymolysis liquid with 4000 revs/min is centrifuged 15 minutes, takes supernatant, with 0.22 μm of membrane filtrations of Kong Jingwei, obtain
Pearl extracting solution.
The mixed enzyme is mixed by 60wt% neutral proteinases and 40wt% papains.
The reparation synergist is polysaccharides.
The preparation method of safety plantation dental restortion liquid, comprises the following steps：By Chinese medicine extract, pearl extracting solution, repair
Synergist, honey are added to the water, and are stirred 40 minutes with 300 revs/min, are planted dental restortion liquid safely.
Embodiment 2
Safety plantation dental restortion liquid raw material (parts by weight)：70 parts of Chinese medical stone water, 25 parts of Chinese medicine extract, pearl extracting solution 15
Part repairs 2 parts of synergist, 8 parts of honey.
The preparation method of the Chinese medicine extract comprises the following steps：
(1) it is small in 70 DEG C of dryings 8 respectively by 25 parts of honeysuckle, 25 parts of Chinese gall, 8 parts of Asian puccoon, 8 parts of radix scutellariae, 3 parts of the root of Dahurain angelica
When, 80 mesh sieves are smashed it through, is uniformly mixed, obtains traditional Chinese medicine powder；
(2) water of 10 times of traditional Chinese medicine powder quality is added in traditional Chinese medicine powder, 55 minutes are kept the temperature at 95 DEG C, with 300 mesh filter-cloth filterings, is received
Collect filtrate A；The water of 8 times of traditional Chinese medicine powder quality is added in the dregs of a decoction, 45 minutes is kept the temperature at 95 DEG C, with 300 mesh filter-cloth filtering wastes, obtains
To liquor B, merge filtrate twice, obtain Chinese medicine extract.
The preparation method of the Chinese medical stone water comprises the following steps：
(1) medical stone surface is cleaned, dries surface moisture, crushed, crossed 100 mesh sieves, obtain medical stone powder；
(2) medical stone powder and water are pressed into solid-to-liquid ratio 1g：15mL mix, 25 DEG C stand 18 it is small when after, at 70 DEG C with 200
Rev/min stirring 4 it is small when, obtain medical stone mixed liquor；
(3) medical stone mixed liquor with 6000 revs/min is centrifuged 15 minutes, supernatant is taken, with 0.22 μm of film mistakes of Kong Jingwei
Filter, obtains Chinese medical stone water.
The preparation method of the pearl extracting solution comprises the following steps：
(1) pearl is cleaned, impurity elimination, crushes, cross 80 mesh sieves, obtain thick pearl powder；
(2) it will be sanded in the grinding cylinder of dispersion machine and add in a diameter of 0.1mm zirconia balls, added in feed paddle cylinder
Ethyl alcohol, starts grinder, 1800 revs/min, feed pressure 0.35kPa of engine speed, while add in thick pearl powder, thick pearl powder and
The solid-to-liquid ratio of ethyl alcohol is 1g：The mass ratio 1 of 20mL, thick pearl powder and zirconia ball：30, it grinds 70 minutes, obtains pearl slurry
Pearl powder slurry with 4000 revs/min is centrifuged 15 minutes, by solid when 65 DEG C of dryings 7 of temperature are small, obtains nanometer level pearl by material
Powder；
(3) nano-glass pearl powder and water are pressed into solid-to-liquid ratio 1g：30mL is mixed, and adds in mixed enzyme, the addition of the mixed enzyme
Amount is the 0.3% of nano-glass pearl powder quality, when 55 DEG C small with 200 revs/min of stirrings 4, keep the temperature 4 minutes at 98 DEG C, obtains enzyme
Solve liquid；
(4) enzymolysis liquid with 4000 revs/min is centrifuged 15 minutes, takes supernatant, with 0.22 μm of membrane filtrations of Kong Jingwei, obtain
Pearl extracting solution.
The mixed enzyme is mixed by 60wt% neutral proteinases and 40wt% papains.
The reparation synergist is polysaccharides.
The preparation method of safety plantation dental restortion liquid, comprises the following steps：By Chinese medicine extract, pearl extracting solution, repair
Synergist, honey are added in Chinese medical stone water, are stirred 40 minutes with 300 revs/min, are planted dental restortion liquid safely.
Comparative example 1
Safety plantation dental restortion liquid raw material (parts by weight)：85 parts of Chinese medical stone water, 25 parts of Chinese medicine extract repair synergist 2
Part, 8 parts of honey.
The preparation method of the Chinese medicine extract comprises the following steps：
(1) it is small in 70 DEG C of dryings 8 respectively by 25 parts of honeysuckle, 25 parts of Chinese gall, 8 parts of Asian puccoon, 8 parts of radix scutellariae, 3 parts of the root of Dahurain angelica
When, 80 mesh sieves are smashed it through, is uniformly mixed, obtains traditional Chinese medicine powder；
(2) water of 10 times of traditional Chinese medicine powder quality is added in traditional Chinese medicine powder, 55 minutes are kept the temperature at 95 DEG C, with 300 mesh filter-cloth filterings, is received
Collect filtrate A；The water of 8 times of traditional Chinese medicine powder quality is added in the dregs of a decoction, 45 minutes is kept the temperature at 95 DEG C, with 300 mesh filter-cloth filtering wastes, obtains
To liquor B, merge filtrate twice, obtain Chinese medicine extract.
The preparation method of the Chinese medical stone water comprises the following steps：
(1) medical stone surface is cleaned, dries surface moisture, crushed, crossed 100 mesh sieves, obtain medical stone powder；
(2) medical stone powder and water are pressed into solid-to-liquid ratio 1g：15mL mix, 25 DEG C stand 18 it is small when after, at 70 DEG C with 200
Rev/min stirring 4 it is small when, obtain medical stone mixed liquor；
(3) medical stone mixed liquor with 6000 revs/min is centrifuged 15 minutes, supernatant is taken, with 0.22 μm of film mistakes of Kong Jingwei
Filter, obtains Chinese medical stone water.
The reparation synergist is polysaccharides.
The preparation method of safety plantation dental restortion liquid, comprises the following steps：By Chinese medicine extract, repair synergist, honey
It is added in Chinese medical stone water, is stirred 40 minutes with 300 revs/min, planted dental restortion liquid safely.
Comparative example 2
Safety plantation dental restortion liquid raw material (parts by weight)：25 parts of Chinese medicine extract, 85 parts of pearl extracting solution repair synergist
2 parts, 8 parts of honey.
The preparation method of the Chinese medicine extract comprises the following steps：
(1) it is small in 70 DEG C of dryings 8 respectively by 25 parts of honeysuckle, 25 parts of Chinese gall, 8 parts of Asian puccoon, 8 parts of radix scutellariae, 3 parts of the root of Dahurain angelica
When, 80 mesh sieves are smashed it through, is uniformly mixed, obtains traditional Chinese medicine powder；
(2) water of 10 times of traditional Chinese medicine powder quality is added in traditional Chinese medicine powder, 55 minutes are kept the temperature at 95 DEG C, with 300 mesh filter-cloth filterings, is received
Collect filtrate A；The water of 8 times of traditional Chinese medicine powder quality is added in the dregs of a decoction, 45 minutes is kept the temperature at 95 DEG C, with 300 mesh filter-cloth filtering wastes, obtains
To liquor B, merge filtrate twice, obtain Chinese medicine extract.
The preparation method of the pearl extracting solution comprises the following steps：
(1) pearl is cleaned, impurity elimination, crushes, cross 80 mesh sieves, obtain thick pearl powder；
(2) it will be sanded in the grinding cylinder of dispersion machine and add in a diameter of 0.1mm zirconia balls, added in feed paddle cylinder
Ethyl alcohol, starts grinder, 1800 revs/min, feed pressure 0.35kPa of engine speed, while add in thick pearl powder, thick pearl powder and
The solid-to-liquid ratio of ethyl alcohol is 1g：The mass ratio 1 of 20mL, thick pearl powder and zirconia ball：30, it grinds 70 minutes, obtains pearl slurry
Pearl powder slurry with 4000 revs/min is centrifuged 15 minutes, by solid when 65 DEG C of dryings 7 of temperature are small, obtains nanometer level pearl by material
Powder；
(3) nano-glass pearl powder and water are pressed into solid-to-liquid ratio 1g：30mL is mixed, and adds in mixed enzyme, the addition of the mixed enzyme
Amount is the 0.3% of nano-glass pearl powder quality, when 55 DEG C small with 200 revs/min of stirrings 4, keep the temperature 4 minutes at 98 DEG C, obtains enzyme
Solve liquid；
(4) enzymolysis liquid with 4000 revs/min is centrifuged 15 minutes, takes supernatant, with 0.22 μm of membrane filtrations of Kong Jingwei, obtain
Pearl extracting solution.
The mixed enzyme is mixed by 60wt% neutral proteinases and 40wt% papains.
The reparation synergist is polysaccharides.
The preparation method of safety plantation dental restortion liquid, comprises the following steps：By Chinese medicine extract, pearl extracting solution, repair
Synergist, honey mixing, are stirred 40 minutes with 300 revs/min, are planted dental restortion liquid safely.
Embodiment 3
Safety plantation dental restortion liquid raw material (parts by weight)：70 parts of Chinese medical stone water, 25 parts of Chinese medicine extract, pearl extracting solution 15
Part repairs 2 parts of synergist, 8 parts of honey.
The preparation method of the Chinese medicine extract comprises the following steps：
(1) it is small in 70 DEG C of dryings 8 respectively by 25 parts of honeysuckle, 25 parts of Chinese gall, 8 parts of Asian puccoon, 8 parts of radix scutellariae, 3 parts of the root of Dahurain angelica
When, 80 mesh sieves are smashed it through, is uniformly mixed, obtains traditional Chinese medicine powder；
(2) water of 10 times of traditional Chinese medicine powder quality is added in traditional Chinese medicine powder, 55 minutes are kept the temperature at 95 DEG C, with 300 mesh filter-cloth filterings, is received
Collect filtrate A；The water of 8 times of traditional Chinese medicine powder quality is added in the dregs of a decoction, 45 minutes is kept the temperature at 95 DEG C, with 300 mesh filter-cloth filtering wastes, obtains
To liquor B, merge filtrate twice, obtain Chinese medicine extract.
The preparation method of the Chinese medical stone water comprises the following steps：
(1) medical stone surface is cleaned, dries surface moisture, crushed, crossed 100 mesh sieves, obtain medical stone powder；
(2) medical stone powder and water are pressed into solid-to-liquid ratio 1g：15mL mix, 25 DEG C stand 18 it is small when after, with acid solution adjust pH
For 6.0, when 70 DEG C small with 200 revs/min of stirrings 4, medical stone mixed liquor is obtained；
(3) medical stone mixed liquor with 6000 revs/min is centrifuged 15 minutes, supernatant is taken, with 0.22 μm of film mistakes of Kong Jingwei
Filter, obtains Chinese medical stone water.
The preparation method of the pearl extracting solution comprises the following steps：
(1) pearl is cleaned, impurity elimination, crushes, cross 80 mesh sieves, obtain thick pearl powder；
(2) it will be sanded in the grinding cylinder of dispersion machine and add in a diameter of 0.1mm zirconia balls, added in feed paddle cylinder
Ethyl alcohol, starts grinder, 1800 revs/min, feed pressure 0.35kPa of engine speed, while add in thick pearl powder, thick pearl powder and
The solid-to-liquid ratio of ethyl alcohol is 1g：The mass ratio 1 of 20mL, thick pearl powder and zirconia ball：30, it grinds 70 minutes, obtains pearl slurry
Pearl powder slurry with 4000 revs/min is centrifuged 15 minutes, by solid when 65 DEG C of dryings 7 of temperature are small, obtains nanometer level pearl by material
Powder；
(3) nano-glass pearl powder and water are pressed into solid-to-liquid ratio 1g：30mL is mixed, and adds in mixed enzyme, the addition of the mixed enzyme
Amount is the 0.3% of nano-glass pearl powder quality, when 55 DEG C small with 200 revs/min of stirrings 4, keep the temperature 4 minutes at 98 DEG C, obtains enzyme
Solve liquid；
(4) enzymolysis liquid with 4000 revs/min is centrifuged 15 minutes, takes supernatant, with 0.22 μm of membrane filtrations of Kong Jingwei, obtain
Pearl extracting solution.
The mixed enzyme is mixed by 60wt% neutral proteinases and 40wt% papains.
The acid solution is the aqueous solutions of organic acids that mass fraction is 8%.
The organic acid is citric acid.
The reparation synergist is polysaccharides.
The preparation method of safety plantation dental restortion liquid, comprises the following steps：By Chinese medicine extract, pearl extracting solution, repair
Synergist, honey are added in Chinese medical stone water, are stirred 40 minutes with 300 revs/min, are planted dental restortion liquid safely.
Embodiment 4
It is substantially the same manner as Example 3, it differs only in, the organic acid is tartaric acid.
Embodiment 5
It is substantially the same manner as Example 3, it differs only in, the organic acid is lactic acid.
Embodiment 6
Safety plantation dental restortion liquid raw material (parts by weight)：70 parts of Chinese medical stone water, 25 parts of Chinese medicine extract, pearl extracting solution 15
Part repairs 2 parts of synergist, 8 parts of honey.
The preparation method of the Chinese medicine extract comprises the following steps：
(1) it is small in 70 DEG C of dryings 8 respectively by 25 parts of honeysuckle, 25 parts of Chinese gall, 8 parts of Asian puccoon, 8 parts of radix scutellariae, 3 parts of the root of Dahurain angelica
When, 80 mesh sieves are smashed it through, is uniformly mixed, obtains traditional Chinese medicine powder；
(2) water of 10 times of traditional Chinese medicine powder quality is added in traditional Chinese medicine powder, 55 minutes are kept the temperature at 95 DEG C, with 300 mesh filter-cloth filterings, is received
Collect filtrate A；The water of 8 times of traditional Chinese medicine powder quality is added in the dregs of a decoction, 45 minutes is kept the temperature at 95 DEG C, with 300 mesh filter-cloth filtering wastes, obtains
To liquor B, merge filtrate twice, obtain Chinese medicine extract.
The preparation method of the Chinese medical stone water comprises the following steps：
(1) medical stone surface is cleaned, dries surface moisture, crushed, crossed 100 mesh sieves, obtain medical stone powder；
(2) medical stone powder and water are pressed into solid-to-liquid ratio 1g：15mL mix, 25 DEG C stand 18 it is small when after, with acid solution adjust pH
For 6.0, when 70 DEG C small with 200 revs/min of stirrings 4, medical stone mixed liquor is obtained；
(3) medical stone mixed liquor with 6000 revs/min is centrifuged 15 minutes, supernatant is taken, with 0.22 μm of film mistakes of Kong Jingwei
Filter, obtains Chinese medical stone water.
The preparation method of the pearl extracting solution comprises the following steps：
(1) pearl is cleaned, impurity elimination, crushes, cross 80 mesh sieves, obtain thick pearl powder；
(2) it will be sanded in the grinding cylinder of dispersion machine and add in a diameter of 0.1mm zirconia balls, added in feed paddle cylinder
Ethyl alcohol, starts grinder, 1800 revs/min, feed pressure 0.35kPa of engine speed, while add in thick pearl powder, thick pearl powder and
The solid-to-liquid ratio of ethyl alcohol is 1g：The mass ratio 1 of 20mL, thick pearl powder and zirconia ball：30, it grinds 70 minutes, obtains pearl slurry
Pearl powder slurry with 4000 revs/min is centrifuged 15 minutes, by solid when 65 DEG C of dryings 7 of temperature are small, obtains nanometer level pearl by material
Powder；
(3) nano-glass pearl powder and water are pressed into solid-to-liquid ratio 1g：30mL is mixed, and adds in mixed enzyme, the addition of the mixed enzyme
Amount is the 0.3% of nano-glass pearl powder quality, when 55 DEG C small with 200 revs/min of stirrings 4, keep the temperature 4 minutes at 98 DEG C, obtains enzyme
Solve liquid；
(4) enzymolysis liquid with 4000 revs/min is centrifuged 15 minutes, takes supernatant, with 0.22 μm of membrane filtrations of Kong Jingwei, obtain
Pearl extracting solution.
The mixed enzyme is mixed by 60wt% neutral proteinases and 40wt% papains.
The acid solution is the aqueous solutions of organic acids that mass fraction is 8%.
The organic acid is lactic acid.
The reparation synergist is soybean polyoses.
The preparation method of safety plantation dental restortion liquid, comprises the following steps：By Chinese medicine extract, pearl extracting solution, repair
Synergist, honey are added in Chinese medical stone water, are stirred 40 minutes with 300 revs/min, are planted dental restortion liquid safely.
The antiphlogistic effects test result of obtained safety plantation dental restortion liquid：Swelling inhibiting rate 39.87%；Fungistatic effect is surveyed
Test result：Candida albicans bacteriostasis rate 88.42%, staphylococcus aureus bacteriostasis rate 89.06%.
Embodiment 7
Safety plantation dental restortion liquid raw material (parts by weight)：70 parts of Chinese medical stone water, 25 parts of Chinese medicine extract, pearl extracting solution 15
Part repairs 2 parts of synergist, 8 parts of honey.
The preparation method of the Chinese medicine extract comprises the following steps：
(1) it is small in 70 DEG C of dryings 8 respectively by 25 parts of honeysuckle, 25 parts of Chinese gall, 8 parts of Asian puccoon, 8 parts of radix scutellariae, 3 parts of the root of Dahurain angelica
When, 80 mesh sieves are smashed it through, is uniformly mixed, obtains traditional Chinese medicine powder；
(2) water of 10 times of traditional Chinese medicine powder quality is added in traditional Chinese medicine powder, 55 minutes are kept the temperature at 95 DEG C, with 300 mesh filter-cloth filterings, is received
Collect filtrate A；The water of 8 times of traditional Chinese medicine powder quality is added in the dregs of a decoction, 45 minutes is kept the temperature at 95 DEG C, with 300 mesh filter-cloth filtering wastes, obtains
To liquor B, merge filtrate twice, obtain Chinese medicine extract.
The preparation method of the Chinese medical stone water comprises the following steps：
(1) medical stone surface is cleaned, dries surface moisture, crushed, crossed 100 mesh sieves, obtain medical stone powder；
(2) medical stone powder and water are pressed into solid-to-liquid ratio 1g：15mL mix, 25 DEG C stand 18 it is small when after, with acid solution adjust pH
For 6.0, when 70 DEG C small with 200 revs/min of stirrings 4, medical stone mixed liquor is obtained；
(3) medical stone mixed liquor with 6000 revs/min is centrifuged 15 minutes, supernatant is taken, with 0.22 μm of film mistakes of Kong Jingwei
Filter, obtains Chinese medical stone water.
The preparation method of the pearl extracting solution comprises the following steps：
(1) pearl is cleaned, impurity elimination, crushes, cross 80 mesh sieves, obtain thick pearl powder；
(2) it will be sanded in the grinding cylinder of dispersion machine and add in a diameter of 0.1mm zirconia balls, added in feed paddle cylinder
Ethyl alcohol, starts grinder, 1800 revs/min, feed pressure 0.35kPa of engine speed, while add in thick pearl powder, thick pearl powder and
The solid-to-liquid ratio of ethyl alcohol is 1g：The mass ratio 1 of 20mL, thick pearl powder and zirconia ball：30, it grinds 70 minutes, obtains pearl slurry
Pearl powder slurry with 4000 revs/min is centrifuged 15 minutes, by solid when 65 DEG C of dryings 7 of temperature are small, obtains nanometer level pearl by material
Powder；
(3) nano-glass pearl powder and water are pressed into solid-to-liquid ratio 1g：30mL is mixed, and adds in mixed enzyme, the addition of the mixed enzyme
Amount is the 0.3% of nano-glass pearl powder quality, when 55 DEG C small with 200 revs/min of stirrings 4, keep the temperature 4 minutes at 98 DEG C, obtains enzyme
Solve liquid；
(4) enzymolysis liquid with 4000 revs/min is centrifuged 15 minutes, takes supernatant, with 0.22 μm of membrane filtrations of Kong Jingwei, obtain
Pearl extracting solution.
The mixed enzyme is mixed by 60wt% neutral proteinases and 40wt% papains.
The acid solution is the aqueous solutions of organic acids that mass fraction is 8%.
The organic acid is lactic acid.
The quality of the mixture for repairing synergist polysaccharides and soybean polyoses, the polysaccharides and soybean polyoses
Than for 4：1.
The preparation method of safety plantation dental restortion liquid, comprises the following steps：By Chinese medicine extract, pearl extracting solution, repair
Synergist, honey are added in Chinese medical stone water, are stirred 40 minutes with 300 revs/min, are planted dental restortion liquid safely.
The antiphlogistic effects test result of obtained safety plantation dental restortion liquid：Swelling inhibiting rate 50.46%；Fungistatic effect is surveyed
Test result：Candida albicans bacteriostasis rate 93.58%, staphylococcus aureus bacteriostasis rate 94.67%.
Test case 1
The antiphlogistic effects of embodiment 1-5 and comparative example 1-2 the safety plantation dental restortion liquid being prepared are tested, are had
Body examination test result is shown in Table 1.
1 safety plantation dental restortion liquid antiphlogistic effects test result table of table
Test case 2
The fungistatic effect of embodiment 1-5 and comparative example 1-2 the safety plantation dental restortion liquid being prepared is tested, is had
Body examination test result is shown in Table 2.
2 fungistatic effect test result table of table
| Candida albicans bacteriostasis rate (%) | Staphylococcus aureus bacteriostasis rate (%) | |
| Embodiment 1 | 80.18 | 82.52 |
| Embodiment 2 | 85.67 | 86.85 |
| Comparative example 1 | 81.24 | 82.89 |
| Comparative example 2 | 82.89 | 83.25 |
| Embodiment 3 | 87.56 | 88.72 |
| Embodiment 4 | 86.78 | 87.36 |
| Embodiment 5 | 89.34 | 90.61 |
Embodiment 2 uses Chinese medical stone water, and the anti-inflammatory and fungistatic effect of obtained safety plantation dental restortion liquid is better than embodiment
1.This is because can boost metabolism containing the element beneficial to human body and element needed by human in Chinese medical stone water,
Immunity is improved, and then improves anti-inflammatory antibacterial effect.
Simultaneously using Chinese medical stone water and pearl extracting solution in embodiment 2, obtained safety plantation dental restortion liquid anti-inflammatory and
Fungistatic effect is better than comparative example 1-2.There are many containing in pearl extracting solution in free amino acid and trace element, and Chinese medical stone water
Beneficial element interaction, be beneficial to body absorption, improve anti-inflammatory antibacterial effect.
Embodiment 3-5 prepares Chinese medical stone water under weakly acidic condition, is planted the anti-inflammatory and antibacterial of dental restortion liquid safely
It is embodiment 2 that effect, which is better than,.This is because the part beneficial element in medical stone is to exist in the form of the oxide, sour environment
Under, be conducive to the dissolution of these beneficial elements.Embodiment 5 adjusts pH using lactic acid simultaneously, and effect is preferable.
Claims (10)
- A kind of 1. safety plantation dental restortion liquid, which is characterized in that the raw material including following weight parts：60-80 parts of water, traditional Chinese medicine extraction 20-30 parts of liquid, 10-20 parts of pearl extracting solution repair 1-5 parts of synergist, 5-10 parts of honey.
- A kind of 2. safety plantation dental restortion liquid, which is characterized in that the raw material including following weight parts：60-80 parts of Chinese medical stone water, in 20-30 parts of medicament extracting solution, 10-20 parts of pearl extracting solution repair 1-5 parts of synergist, 5-10 parts of honey.
- 3. safety plantation dental restortion liquid as claimed in claim 2, which is characterized in that the preparation method of the Chinese medical stone water includes Following steps：(1) medical stone surface is cleaned, dries surface moisture, crushed, crossed 100 mesh sieves, obtain medical stone powder；(2) medical stone powder and water are pressed into solid-to-liquid ratio 1g：(10-20) mL mix, 20-30 DEG C stand 12-24 it is small when after, in 60- 80 DEG C with 100-300 revs/min stirring 2-6 it is small when, obtain medical stone mixed liquor；(3) medical stone mixed liquor with 4000-8000 revs/min is centrifuged 10-20 minutes, takes supernatant, with 0.22 μm of Kong Jingwei's Membrane filtration obtains Chinese medical stone water.
- 4. safety plantation dental restortion liquid as claimed in claim 2, which is characterized in that the preparation method of the Chinese medical stone water includes Following steps：(1) medical stone surface is cleaned, dries surface moisture, crushed, crossed 100 mesh sieves, obtain medical stone powder；(2) medical stone powder and water are pressed into solid-to-liquid ratio 1g：(10-20) mL mix, 20-30 DEG C stand 12-24 it is small when after, use acid solution Adjusting pH is 5.5-6.5, when 60-80 DEG C small with 100-300 revs/min of stirring 2-6, obtains medical stone mixed liquor；(3) medical stone mixed liquor with 4000-8000 revs/min is centrifuged 10-20 minutes, takes supernatant, with 0.22 μm of Kong Jingwei's Membrane filtration obtains Chinese medical stone water.
- 5. safety plantation dental restortion liquid as claimed in claim 1 or 2, which is characterized in that the preparation side of the pearl extracting solution Method comprises the following steps：(1) pearl is cleaned, impurity elimination, crushes, obtain thick pearl powder；(2) it will be sanded in the grinding cylinder of dispersion machine and add in a diameter of 0.1mm zirconia balls, second is added in feed paddle cylinder Alcohol starts grinder, while adds in thick pearl powder, and the solid-to-liquid ratio of thick pearl powder and ethyl alcohol is 1g：(15-25) mL grinds 65-75 Minute, pearl powder slurry is obtained, pearl powder slurry is centrifuged 10-20 minutes with 3000-5000 revs/min, by solid in temperature 60- When 70 DEG C of dry 6-8 are small, nano-glass pearl powder is obtained；(3) nano-glass pearl powder and water are pressed into solid-to-liquid ratio 1g：(20-40) mL is mixed, and adds in mixed enzyme, the addition of the mixed enzyme Amount is the 0.1-0.5% of nano-glass pearl powder quality, when 50-60 DEG C small with 100-300 revs/min of stirring 2-6, at 95-100 DEG C Heat preservation 3-5 minutes, obtains enzymolysis liquid；(4) enzymolysis liquid with 3000-5000 revs/min is centrifuged 10-20 minutes, takes supernatant, with 0.22 μm of membrane filtrations of Kong Jingwei, Obtain pearl extracting solution；The mixed enzyme is mixed by 50-70wt% neutral proteinases and 30-50wt% papains.
- 6. safety plantation dental restortion liquid as claimed in claim 1 or 2, which is characterized in that the preparation side of the Chinese medicine extract Method comprises the following steps：(1) by 20-30 parts of honeysuckle, 20-30 parts of Chinese gall, 5-10 parts of Asian puccoon, 5-10 parts of radix scutellariae, 1-5 parts of the root of Dahurain angelica, exist respectively When 60-80 DEG C of dry 6-10 is small, it is uniformly mixed after crushing, obtains traditional Chinese medicine powder；(2) water of 8-12 times of traditional Chinese medicine powder quality is added in traditional Chinese medicine powder, 50-60 minutes are kept the temperature at 90-98 DEG C, with 300 mesh filter cloth mistakes Filtrate A is collected in filter；The water of 5-10 times of traditional Chinese medicine powder quality is added in the dregs of a decoction, 40-50 minutes are kept the temperature at 90-98 DEG C, with 300 mesh Filter-cloth filtering waste obtains liquor B, merges filtrate twice, obtains Chinese medicine extract.
- 7. safety plantation dental restortion liquid as claimed in claim 4, which is characterized in that the acid solution is that mass fraction is 5-10% Aqueous solutions of organic acids, the organic acid is citric acid, tartaric acid, one kind in lactic acid.
- 8. safety plantation dental restortion liquid as claimed in claim 7, which is characterized in that the organic acid is lactic acid.
- 9. safety plantation dental restortion liquid as claimed in claim 2, which is characterized in that the reparation synergist is polysaccharides And/or soybean polyoses.
- 10. if claim 2-9 any one of them plants safely the preparation method of dental restortion liquid, comprise the following steps：By in Medicament extracting solution, pearl extracting solution, reparation synergist, honey are added in Chinese medical stone water, with 200-400 revs/min of 30-60 points of stirring Clock is planted safely dental restortion liquid.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101077079A (en) * | 2006-05-25 | 2007-11-28 | 西安格润森生物制药股份有限公司 | Plant-type antibacterial agent |
| CN104399973A (en) * | 2014-12-11 | 2015-03-11 | 北海银源医药科技有限公司 | Disperse protective agent prepared from pearl and momordica grosvenori extract and application thereof |
| CN107625135A (en) * | 2017-10-10 | 2018-01-26 | 林翠霞 | A kind of health food for adjusting female incretion |
-
2018
- 2018-02-05 CN CN201810112110.5A patent/CN108042610B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101077079A (en) * | 2006-05-25 | 2007-11-28 | 西安格润森生物制药股份有限公司 | Plant-type antibacterial agent |
| CN104399973A (en) * | 2014-12-11 | 2015-03-11 | 北海银源医药科技有限公司 | Disperse protective agent prepared from pearl and momordica grosvenori extract and application thereof |
| CN107625135A (en) * | 2017-10-10 | 2018-01-26 | 林翠霞 | A kind of health food for adjusting female incretion |
Non-Patent Citations (3)
| Title |
|---|
| 毛秋华，等: ""纳米级淡水珍珠粉的制备研究"", 《口腔医学研究》 * |
| 王汉明，等，: ""银蒲解毒含漱液对大鼠实验性牙周炎的治疗作用"", 《临床口腔医学杂志》 * |
| 雷雨，等: ""绞股蓝麦饭石保健饮料的研制"", 《食品科学》 * |
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