CN105832992A - Preparation method for cimicifuga dahuria throat-clearing buccal tablet - Google Patents
Preparation method for cimicifuga dahuria throat-clearing buccal tablet Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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Abstract
The invention discloses a preparation method for a cimicifuga dahuria throat-clearing buccal tablet, and relates to a preparation method for a preparation of the throat-clearing buccal tablet. The preparation method mainly solves the problem that extract of a current buccal tablet for clearing the throat prepared through a common extracting method is poor in mouthfeel under tongue while being tabletted, has a sticky feeling, and is low in bioavailability, and auxiliary materials such as saccharose and starch are easily stuck on teeth to cause decayed teeth. The preparation method for the cimicifuga dahuria throat-clearing buccal tablet comprises the following steps: I, screening raw and auxiliary materials; II, weighing the raw and auxiliary materials; III, mixing the raw materials; IV, mixing the auxiliary materials; V, mixing the raw and auxiliary materials; VI, stirring and pelletizing the raw and auxiliary materials at a high speed; VII, drying; VIII, pelletizing; IX, mixing; and X, tabletting. According to the preparation method, the cimicifuga dahuria throat-clearing buccal tablet prepared by extract prepared by adopting a semi-bionic-enzyme extraction technology is good in mouthfeel, is quick in effect-taking, is high in bioavailability under tongue, is free of a sticking feeling under tongue, is not struck on gingivae and teeth, is refreshing, and does not easily cause decayed teeth; and modern pharmaceutical equipment is adopted, so that the industrial production requirements can be met.
Description
Technical field
The present invention relates to the preparation method with the health food rhizoma cimicifugae dahuricae guttural tablets of function of moistening and cleaning throat.
Background technology
Lozenge has taking convenience, some drugs by mucosal absorption without liver first-pass effect bioavilability
The advantage such as high, rapid-action.Therefore clearing health product makes lozenge application more.Guttural tablets has clearing throat,
Alleviating the function of throat discomfort, for acute/chronic pharyngitis, what laryngopharynx fatigue caused do, itch, swell and ache, and expectoration is not well
Etc. symptom.In air, the atmosphere pollution such as PM2.5, sulfur dioxide is more serious in recent years, and pharyngitis is shown effect in the biggest
Width ascendant trend, the disease of pharynx that the guttural tablets protection reason such as organism endocrine and outside environmental elements causes, tool
Have a wide range of applications.On market, the formulation of clearing kind is a lot, has beverage, particle, tablet, capsule etc. many
Kind of formulation, lozenge due to be convenient for carrying and steady quality, taking convenience and be used widely.
Rhizoma cimicifugae dahuricae is the dry rhizome of Ranunculaceae Cimicifuga Dahurica, has another name called hole bud root, bitter old dish root, has and deliver,
Promoting eruption, removing toxic substances, effect of yang invigorating.It is clinically used for gas plague during treatment, fever and chills of having a headache, laryngalgia, aphtha,
Macula is impermeable；Rushing down protracted dysentery, prolapse of the anus as long as the sinking of qi of middle-jiao, women collapses band, and uterus drops；Carbuncle sore tumefacting virus, stomach fire tooth
Pain etc..The present invention uses pure northeast genunie medicinal materials rhizoma cimicifugae dahuricae, great burdock achene, fritillary bulb to instruct in traditional Chinese medicine theory
Lower compatibility, and combine the theory of modern's health care, it is made into the lozenge with clearing health care.
The existing technique of clearing class lozenge is disadvantageous in that: clearing class preparation many employings starch, dextrin, sucrose are made
For filler auxiliary material pelletizing press sheet, though medicine has the effect of clearing, but active ingredient is easily by starch, dextrin etc.
Insoluble auxiliary material adsorption loss, and starch, dextrin, sucrose sucks clouding, has viscous sense so that absorb onset
Slowly, bioavilability is low, it is impossible to quickly reach clearing, the effect of protection throat function.And general preparation side
Method uses starch, sucrose, dextrin are easily adhered on tooth, gum, induce carious tooth.Original guttural tablets class
Kind can not meet the needs of current throat health care crowd, and therefore range is greatly limited.
Summary of the invention
The invention aims to solve existing guttural tablets health products and there is the release of product active ingredient not exclusively, suck
Bioavilability is low, and mouthfeel is clouding, and it is too much that ordinary adjuvants adheres to tooth gum, induction carious tooth and production craft step,
The problems such as the consumption energy is high, and pollutant discharge amount is relatively more, thus the preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets is provided.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets of the present invention, it is to sequentially include the following steps:
One, sieve: take rhizoma cimicifugae dahuricae extract powder, burdock extract powder, Bulbus Fritillariae Ussuriensis extract powder, xylitol, erythrose
Alcohol, maltodextrin, glycyrrhizin, malic acid and peppermint powdered flavor cross 100 mesh sieves, and magnesium stearate crosses 200 mesh sieves；
Two, weigh: take each component after step one is sieved, weigh by following mass fraction: the rhizoma cimicifugae dahuricae of 60～180 parts carries
Take thing powder, the burdock extract powder of 50～130 parts, the Bulbus Fritillariae Ussuriensis extract powder of 30～90 parts, the xylitol of 150～350 parts,
The antierythrite of 150～350 parts, the maltodextrin of 100～300 parts, the peppermint powdered flavor of 10～30 parts, 1.0～3.0 parts
Glycyrrhizin, the malic acid of 3.0～9.0 parts, the volumn concentration of 150～400 parts are 85% ethanol solution and 2.0～7.0
The magnesium stearate of part；
Three, raw material mixing: rhizoma cimicifugae dahuricae extract powder that step 2 is weighed, burdock extract powder peace fritillaria extract powder
Mix and blend 10～15min, obtains raw material medicinal powder；
Four, auxiliary material mixing: the malic acid that step 2 weighed, glycyrrhizin, peppermint powdered flavor use high-speed stirred mixing
Machine mixes 5～10min with xylitol, antierythrite, maltodextrin, obtains uniform auxiliary materials mixture；
Five, supplementary material always mixes: the auxiliary material mixture that raw material medicinal powder step 3 prepared prepares with step 4 mixes 8～15min,
Obtain supplementary material mixture；
Six, High Shear Mixer Granulator: insert in High Speed Stirring Machine by the supplementary material mixture that step 5 prepares, adds step
Two volumn concentrations weighed are 85% ethanol solution, arrange mixing rotating speed 300～500rpm, cutting rotating speed 1500～
Pelletize under the conditions of 2000rpm；
Seven, it is dried: the wet granular that step 6 prepares is placed in hot air circulation drying oven, at the bar that temperature is 40～50 DEG C
The moisture being dried under part to particle is less than 5.0%；
Eight, whole grain: the particle after step 7 being dried crosses the 18 whole grains of mesh sieve；
Nine, always mix: peppermint powdered flavor step 2 weighed and magnesium stearate join in the dry particle that step 8 prepares,
Stirring mixing 5～15min, obtains and always mixes particle；
Ten, compressing tablet: total mixed particle step 9 prepared carries out compressing tablet, and tablet weight is 1.0g/ sheet, obtains rhizoma cimicifugae dahuricae clearing and contains
Sheet.
The present invention comprises following beneficial effect:
In the preparation process of the rhizoma cimicifugae dahuricae guttural tablets of the present invention, use the extract that half bionic enzyme extractive technique prepares
Prepare guttural tablets, it is possible to the active ingredient in medicinal material is fully extracted, easily digests and assimilates, and preparation mouthfeel
Clearly, maltodextrin, xylitol and antierythrite is used can to prevent sugary auxiliary material from adhering to tooth, gum as auxiliary material, it is to avoid
Induction carious tooth, better stability of preparation, exposure experiments to light, hot test in uniformity of dosage units and influence factor are the most stable,
Under high humidity experimental condition, content has no significant change.
The preparation method of rhizoma cimicifugae dahuricae guttural tablets of the present invention, can meet the needs of most domestic manufacturer production present situation, uses existing
The pharmaceutical equipment producing tablet is had to produce, it is not necessary to newly increase equipment investment.
The prescription of rhizoma cimicifugae dahuricae guttural tablets of the present invention is according to following Chinese Traditional Medicine therapy theory and combining modern health theory
Guiding theory, use modern pharmaceutical technology and the method for inspection, summed up with rhizoma cimicifugae dahuricae guttural tablets preparation more
The technological parameter joined, and with the isoferulic acid content in rhizoma cimicifugae dahuricae and the arctiin content in great burdock achene as monitor control index,
Ensure the security of rhizoma cimicifugae dahuricae guttural tablets, validity, stability.The rhizoma cimicifugae dahuricae guttural tablets mouthfeel that the present invention prepares
Good, function of moistening and cleaning throat is definite, has good preventing and treating health-care effect to the related oral disease such as pharyngitis, canker sore, can be more preferably
For acute/chronic pharyngitis patient service.
Detailed description of the invention
Technical solution of the present invention is not limited to act detailed description of the invention set forth below, and also include between each detailed description of the invention is any
Combination.
Detailed description of the invention one: the preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets of present embodiment, it is according to the following steps
Carry out:
One, sieve: take rhizoma cimicifugae dahuricae extract powder, burdock extract powder, Bulbus Fritillariae Ussuriensis extract powder, xylitol, erythrose
Alcohol, maltodextrin, glycyrrhizin, malic acid and peppermint powdered flavor cross 100 mesh sieves, and magnesium stearate crosses 200 mesh sieves；
Two, weigh: take each component after step one is sieved, weigh by following mass fraction: the rhizoma cimicifugae dahuricae of 60～180 parts carries
Take thing powder, the burdock extract powder of 50～130 parts, the Bulbus Fritillariae Ussuriensis extract powder of 30～90 parts, the xylitol of 150～350 parts,
The antierythrite of 150～350 parts, the maltodextrin of 100～300 parts, the peppermint powdered flavor of 10～30 parts, 1.0～3.0 parts
Glycyrrhizin, the malic acid of 3.0～9.0 parts, the volumn concentration of 150～400 parts are 85% ethanol solution and 2.0～7.0
The magnesium stearate of part；
Three, raw material mixing: rhizoma cimicifugae dahuricae extract powder that step 2 is weighed, burdock extract powder peace fritillaria extract powder
Mix and blend 10～15min, obtains raw material medicinal powder；
Four, auxiliary material mixing: the malic acid that step 2 weighed, glycyrrhizin, peppermint powdered flavor use high-speed stirred mixing
Machine mixes 5～10min with xylitol, antierythrite, maltodextrin, obtains uniform auxiliary materials mixture；
Five, supplementary material always mixes: the auxiliary material mixture that raw material medicinal powder step 3 prepared prepares with step 4 mixes 8～15min,
Obtain supplementary material mixture；
Six, High Shear Mixer Granulator: insert in High Speed Stirring Machine by the supplementary material mixture that step 5 prepares, adds step
Two volumn concentrations weighed are 85% ethanol solution, arrange mixing rotating speed 300～500rpm, cutting rotating speed 1500～
Pelletize under the conditions of 2000rpm；
Seven, it is dried: the wet granular that step 6 prepares is placed in hot air circulation drying oven, at the bar that temperature is 40～50 DEG C
The moisture being dried under part to particle is less than 5.0%；
Eight, whole grain: the particle after step 7 being dried crosses the 18 whole grains of mesh sieve；
Nine, always mix: peppermint powdered flavor step 2 weighed and magnesium stearate join in the dry particle that step 8 prepares,
Stirring mixing 5～15min, obtains and always mixes particle；
Ten, compressing tablet: total mixed particle step 9 prepared carries out compressing tablet, and tablet weight is 1.0g/ sheet, obtains rhizoma cimicifugae dahuricae clearing and contains
Sheet.
The rhizoma cimicifugae dahuricae guttural tablets that present embodiment prepares prepares preparation, clean taste, does not adhere to tooth, gum, it is to avoid lure
Send out carious tooth；Its refined extract using medicinal material not contain polysaccharide prepares preparation, better stability of preparation, dispersed homogeneous degree and shadow
Exposure experiments to light, hot test in the factor of sound are the most stable, and under high humidity experimental condition, content has no significant change.
The preparation method of present embodiment rhizoma cimicifugae dahuricae guttural tablets, can meet the needs of most domestic manufacturer production present situation, no
Plant and equipment investment must be increased newly.
The present invention follows traditional Chinese medicine theory and the guiding theory of modern health theory, uses modern pharmaceutical technology and inspection
Proved recipe method, has made the technological parameter mated with rhizoma cimicifugae dahuricae guttural tablets preparation, and with rhizoma cimicifugae dahuricae composition isoferulic acid
Content and great burdock achene characteristic component arctiin content as monitor control index, can ensure that rhizoma cimicifugae dahuricae guttural tablets security,
Validity, stability, it is ensured that it can effectively play the function of clearing.The rhizoma cimicifugae dahuricae guttural tablets safety that the present invention prepares
Effectively, there is positive clearing meaning, can be preferably acute/chronic pharyngitis crowd and by haze pollute cause breathe decorum disease
Crowd provides good health care service.
Detailed description of the invention two: present embodiment is unlike detailed description of the invention one: take step described in step 2
One sieve after each component, weigh by following mass fraction: the rhizoma cimicifugae dahuricae extract powder of 60～160 parts, the ox of 50～120 parts
Burdock seed extract powder, the Bulbus Fritillariae Ussuriensis extract powder of 30～80 parts, the xylitol of 150～300 parts, the erythrose of 150～300 parts
Alcohol, the maltodextrin of 100～280 parts, the peppermint powdered flavor of 10～28 parts, the glycyrrhizin of 1.0～2.8 parts, 3.0～8.0
The malic acid of part, the volumn concentration of 150～350 parts are 85% ethanol solution and the magnesium stearate of 2.0～6.0 parts.Other
Identical with detailed description of the invention one.
Detailed description of the invention three: present embodiment is unlike detailed description of the invention one or two: taking described in step 2
Step one sieve after each component, weigh by following mass fraction: the rhizoma cimicifugae dahuricae extract powder of 60～140 parts, 50～110 parts
Burdock extract powder, the Bulbus Fritillariae Ussuriensis extract powder of 30～70 parts, the xylitol of 150～250 parts, 150～250 parts red
Moss sugar alcohol, the maltodextrin of 100～240 parts, the peppermint powdered flavor of 10～24 parts, the glycyrrhizin of 1.0～2.4 parts, 3.0～7.0
The malic acid of part, the volumn concentration of 150～300 parts are 85% ethanol solution and the magnesium stearate of 2.0～5.0 parts.Other
Identical with detailed description of the invention one or two.
Detailed description of the invention four: present embodiment is unlike one of detailed description of the invention one to three: institute in step 2
The each component taken after step one is sieved stated, is weighed by following mass fraction: the rhizoma cimicifugae dahuricae extract powder of 120 parts, 90 parts
Burdock extract powder, the Bulbus Fritillariae Ussuriensis extract powder of 60 parts, the xylitol of 250 parts, the antierythrite of 250 parts, 198 parts
Maltodextrin, the peppermint powdered flavor of 20 parts, the glycyrrhizin of 2.0 parts, the malic acid of 6.0 parts, the volume hundred of 250 parts
Dividing content is 85% ethanol solution and the magnesium stearate of 4.0 parts.Other is identical with one of detailed description of the invention one to three.
Detailed description of the invention five: present embodiment is unlike one of detailed description of the invention one to four: step 5 prepares
Supplementary material mixture insert in High Speed Stirring Machine, adding the volumn concentration that weighs of step 2 is that 80% ethanol is molten
Pelletize under the conditions of liquid.Other is identical with one of detailed description of the invention one to four.
Detailed description of the invention six: present embodiment is unlike one of detailed description of the invention one to five: set in step 5
Put mixing rotating speed 450～600rpm, pelletize under the conditions of cutting rotating speed 1800～2500rpm.Other and detailed description of the invention
One of one to five identical.
Detailed description of the invention seven: present embodiment is unlike one of detailed description of the invention one to five: described north liter
Nettle extract powder, the extracting method of burdock extract powder peace fritillaria extract powder are entered for employing half bionical-enzyme extracting method
Row extracts.Other is identical with one of detailed description of the invention one to five.
Detailed description of the invention eight: present embodiment is unlike one of detailed description of the invention one to five: described half is imitative
Life-enzyme extracting method is: takes pulverizing medicinal materials to be extracted and crosses 20 mesh, and by every, it is 2.0 that 1kg adds 20 times amount pH value
Cushioning liquid, after mixing, adds cellulase, soaks 2 hours, filter；The dregs of a decoction add 10 times and are washed to neutrality,
Adding 20 times amount pH value is the cushioning liquid of 5, adds mixed enzyme, filters；Collect filtrate, concentrate, dry, mixed
Close, pulverize and get final product.Other is identical with one of detailed description of the invention one to five.
By following example checking beneficial effects of the present invention:
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets of the present embodiment is to sequentially include the following steps:
One, sieve: take rhizoma cimicifugae dahuricae extract powder prepared by half bionic enzyme extractive technique, burdock extract powder, flat shellfish
Female extract powder, xylitol, antierythrite, maltodextrin, glycyrrhizin, malic acid and peppermint powdered flavor cross 100
Mesh sieve, magnesium stearate crosses 200 mesh sieves；
Two, weigh: take each component after step one is sieved, weigh by following mass fraction: the rhizoma cimicifugae dahuricae of 60～180 parts carries
Take thing powder, the burdock extract powder of 50～130 parts, the Bulbus Fritillariae Ussuriensis extract powder of 30～90 parts, the xylitol of 150～350 parts,
The antierythrite of 150～350 parts, the maltodextrin of 100～300 parts, the peppermint powdered flavor of 10～30 parts, 1.0～3.0 parts
Glycyrrhizin, the malic acid of 3.0～9.0 parts, 85% ethanol solution of 150～400 parts and the magnesium stearate of 2.0～7.0 parts；
Three, raw material mixing: rhizoma cimicifugae dahuricae extract powder that step 2 is weighed, burdock extract powder peace fritillaria extract powder
Mix and blend 10～15min, obtains raw material medicinal powder；
Four, auxiliary material mixing: the malic acid that step 2 weighed, glycyrrhizin, peppermint powdered flavor use high-speed stirred mixing
Machine mixes 5～10min with xylitol, antierythrite, maltodextrin, obtains uniform auxiliary materials mixture；
Five, supplementary material always mixes: the auxiliary material mixture that raw material medicinal powder step 3 prepared prepares with step 4 mixes 8～15min,
Obtain supplementary material mixture；
Six, High Shear Mixer Granulator: insert in High Speed Stirring Machine by the supplementary material mixture that step 5 prepares, adds step
Two 85% ethanol solutions weighed, arrange mixing rotating speed 300～500r.p.m, cut rotating speed 1500～2000r.p.m condition
Lower granulation；
Seven, it is dried: the wet granular that step 6 prepares is placed in hot air circulation drying oven, at the bar that temperature is 40～50 DEG C
The moisture being dried under part to particle is less than 5.0%；
Eight, whole grain: the particle after step 7 being dried crosses the 18 whole grains of mesh sieve；
Nine, always mix: peppermint powdered flavor step 2 weighed and magnesium stearate join in the dry particle that step 8 prepares,
Stirring mixing 5～15min, obtains and always mixes particle；
Ten, compressing tablet: total mixed particle step 9 prepared carries out compressing tablet, and tablet weight is 1.0g/ sheet, obtains rhizoma cimicifugae dahuricae clearing and contains
Sheet.
Rhizoma cimicifugae dahuricae guttural tablets preparation prepared by present embodiment, clean taste, do not adhere to tooth, gum, it is to avoid induction dental caries
Tooth；The refined extract using medicinal material Polysaccharide removing prepares preparation, better stability of preparation, dispersed homogeneous degree and influence factor
In exposure experiments to light, hot test the most stable, under high humidity experimental condition, content has no significant change.
Rhizoma cimicifugae dahuricae guttural tablets detailed description of the invention six prepared, carries out clinical testing:
Test for the volunteer that 200 example clinical diagnosises are chronic pharyngitis: the maleest 129 people, female 71 people, age
Maximum 68 years old, at minimum 19 years old of age, the course of disease about 1～5 year, wherein severe chronic pharyngitis patient 27 people, moderate chronic was swallowed
Scorching patient 112 people, slight patients with chronic pharyngitis 61 people.
Experiment exam method index: test uses own control design, experimenter's voluntary participation, buccal rhizoma cimicifugae dahuricae clearing every day
Lozenge 3 times, each buccal 1, continuous application 4 weeks.Pharyngeal symptom is observed respectively, in detail the clinical table of record before and after test
The pharyngalgia levied, pharynx is itched, throat is scorching hot, foreign body sensation in the throat, throat are dry and astringent, expectoration is not well, many speeches increase the weight of, respectively according to
The weight of symptom is marked by clinical pharyngitis diagnostic criteria: severe 3 points, moderate 2 points, slight 1 point.Carry out before and after medication point
Value contrast, symptom alleviates more than 2 points or transference cure is effective；It is effective that symptom alleviates more than 1 point；Exacerbation of symptoms or nothing
Change is following is invalid, is estimated the function of rhizoma cimicifugae dahuricae guttural tablets.
Result: after rhizoma cimicifugae dahuricae guttural tablets uses: in severe chronic pharyngitis 27 people, effective 5 examples, effective 16 examples are invalid
6 examples；In moderate chronic pharyngitis patient 112 people, effective 61 examples, effective 32 examples, invalid 19 examples；Slight chronic pharyngitis
Effective 42 examples in patient, effective 16 examples, invalid 3 examples, overall efficiency is 86%.Rhizoma cimicifugae dahuricae guttural tablets can be effective
For chronic pharyngitis symptom so that pharyngalgia, pharynx is itched, throat is scorching hot, foreign body sensation in the throat, throat are dry and astringent, expectoration is not well, many
The symptoms such as speech pharyngalgia increases the weight of alleviate or disappear, rhizoma cimicifugae dahuricae guttural tablets in use clean taste, the sweet micro-hardship of gas fragrance,
Good patient compliance, can adhere to taking, and does not finds that these health products have obvious bad reaction in clinical test-meal process of the test.
Therefore, rhizoma cimicifugae dahuricae guttural tablets is a kind of health care definitely good clearing class health food of safety.
Claims (10)
1. the preparation method of a rhizoma cimicifugae dahuricae guttural tablets, it is characterised in that it is to sequentially include the following steps:
One, sieve: take rhizoma cimicifugae dahuricae extract powder, burdock extract powder, Bulbus Fritillariae Ussuriensis extract powder, xylitol, erythrose
Alcohol, maltodextrin, glycyrrhizin, malic acid and peppermint powdered flavor cross 100 mesh sieves, and magnesium stearate crosses 200 mesh sieves；
Two, weigh: take each component after step one is sieved, weigh by following mass fraction: the rhizoma cimicifugae dahuricae of 60～180 parts extracts
Thing powder, the burdock extract powder of 50～130 parts, the Bulbus Fritillariae Ussuriensis extract powder of 30～90 parts, the xylitol of 150～350 parts,
The antierythrite of 150～350 parts, the maltodextrin of 100～300 parts, the peppermint powdered flavor of 10～30 parts, 1.0～3.0 parts sweet
Grass glucin, the malic acid of 3.0～9.0 parts, the volumn concentration of 150～400 parts are 85% ethanol solution and 2.0～7.0 parts
Magnesium stearate；
Three, raw material mixing: rhizoma cimicifugae dahuricae extract powder that step 2 is weighed, burdock extract powder peace fritillaria extract powder
Mix and blend 10～15min, obtains raw material medicinal powder；
Four, auxiliary material mixing: the malic acid that step 2 weighed, glycyrrhizin, peppermint powdered flavor use high-speed stirred mixing
Machine mixes 5～10min with xylitol, antierythrite, maltodextrin, obtains uniform auxiliary materials mixture；
Five, supplementary material always mixes: the auxiliary material mixture that raw material medicinal powder step 3 prepared prepares with step 4 mixes 8～15min,
Obtain supplementary material mixture；
Six, High Shear Mixer Granulator: insert in High Speed Stirring Machine by the supplementary material mixture that step 5 prepares, adds step
Two volumn concentrations weighed are 85% ethanol solution, arrange mixing rotating speed 300～500rpm, cut rotating speed 1500～2000
Pelletize under the conditions of rpm；
Seven, it is dried: the wet granular that step 6 prepares is placed in hot air circulation drying oven, in the condition that temperature is 40～50 DEG C
The moisture being dried down to particle is less than 5.0%；
Eight, whole grain: the particle after step 7 being dried crosses the 18 whole grains of mesh sieve；
Nine, always mix: peppermint powdered flavor step 2 weighed and magnesium stearate join in the dry particle that step 8 prepares,
Stirring mixing 5～15min, obtains and always mixes particle；
Ten, compressing tablet: total mixed particle step 9 prepared carries out compressing tablet, and tablet weight is 1.0g/ sheet, obtains rhizoma cimicifugae dahuricae guttural tablets.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets the most according to claim 1, it is characterised in that described rhizoma cimicifugae dahuricae
Extract powder, the extracting method of burdock extract powder peace fritillaria extract powder carry for employing half bionical-enzyme extracting method
Take.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets the most according to claim 2, it is characterised in that described half is bionical
-enzyme extracting method is: takes pulverizing medicinal materials to be extracted and crosses 20 mesh, and by every, it is the buffering of 2.0 that 1kg adds 20 times amount pH value
Solution, after mixing, adds cellulase, soaks 2 hours, filter；The dregs of a decoction add 10 times and are washed to neutrality, add
20 times amount pH value are the cushioning liquid of 5, add mixed enzyme, filter；Collect filtrate, concentrate, dry, mixing, pulverize
Obtain.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets the most according to claim 1, it is characterised in that described in step 2
The each component taken after step one is sieved, weigh by following mass fraction: the rhizoma cimicifugae dahuricae extract powder of 60～160 parts, 50～120
Part burdock extract powder, the Bulbus Fritillariae Ussuriensis extract powder of 30～80 parts, the xylitol of 150～300 parts, 150～300 parts red
Moss sugar alcohol, the maltodextrin of 100～280 parts, the peppermint powdered flavor of 10～28 parts, the glycyrrhizin of 1.0～2.8 parts, 3.0～8.0
The malic acid of part, the volumn concentration of 150～350 parts are 85% ethanol solution and the magnesium stearate of 2.0～6.0 parts.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets the most according to claim 4, it is characterised in that described in step 2
The each component taken after step one is sieved, weigh by following mass fraction: the rhizoma cimicifugae dahuricae extract powder of 60～140 parts, 50～110
Part burdock extract powder, the Bulbus Fritillariae Ussuriensis extract powder of 30～70 parts, the xylitol of 150～250 parts, 150～250 parts red
Moss sugar alcohol, the maltodextrin of 100～240 parts, the peppermint powdered flavor of 10～24 parts, the glycyrrhizin of 1.0～2.4 parts, 3.0～7.0
The malic acid of part, the volumn concentration of 150～300 parts are 85% ethanol solution and the magnesium stearate of 2.0～5.0 parts.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets the most according to claim 5, it is characterised in that described in step 2
The each component taken after step one is sieved, weigh by following mass fraction: the rhizoma cimicifugae dahuricae extract powder of 80～140 parts, 80～110
Part burdock extract powder, the Bulbus Fritillariae Ussuriensis extract powder of 50～70 parts, the xylitol of 180～250 parts, 180～250 parts red
Moss sugar alcohol, the maltodextrin of 150～240 parts, the peppermint powdered flavor of 15～24 parts, the glycyrrhizin of 1.5～2.4 parts, 4.0～7.0
The malic acid of part, the volumn concentration of 180～300 parts are 85% ethanol solution and the magnesium stearate of 2.0～5.0 parts.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets the most according to claim 6, it is characterised in that described in step 2
The each component taken after step one is sieved, weigh by following mass fraction: the rhizoma cimicifugae dahuricae extract powder of 120 parts, the ox of 90 parts
Burdock seed extract powder, the Bulbus Fritillariae Ussuriensis extract powder of 60 parts, the xylitol of 250 parts, the antierythrite of 250 parts, the wheat of 198 parts
Bud dextrin, the peppermint powdered flavor of 20 parts, the glycyrrhizin of 2.0 parts, the malic acid of 6.0 parts, the volume basis of 250 parts contain
Amount is 85% ethanol solution and the magnesium stearate of 4.0 parts.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets the most according to claim 1, it is characterised in that described in step 4
Auxiliary material mixing use homogenizer quickly mix.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets the most according to claim 1, it is characterised in that described in step 6
Employing High Shear Mixer Granulator.
The preparation method of a kind of rhizoma cimicifugae dahuricae guttural tablets the most according to claim 1, it is characterised in that institute in step 6
The High Shear Mixer Granulator stated arranges mixing rotating speed 300～500rpm, pelletizes under the conditions of cutting rotating speed 1500～2000rpm.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215073A (en) * | 2016-08-23 | 2016-12-14 | 哈药集团中药二厂 | A kind of preparation method of Fructus Alpiniae Oxyphyllae reducing urination sheet |
| CN106309623A (en) * | 2016-08-23 | 2017-01-11 | 哈药集团中药二厂 | Centella freckle removing chewable tablet preparing method |
| CN109832608A (en) * | 2017-11-28 | 2019-06-04 | 内蒙古伊利实业集团股份有限公司 | Alleviate the probiotics draft food compositions and its process for preparing buccal lozenge of throat discomfort |
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| CN104825835A (en) * | 2015-04-25 | 2015-08-12 | 哈药集团中药二厂 | Preparation method of dendrobium nobile oral ulcer buccal tablet |
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- 2016-04-25 CN CN201610264660.XA patent/CN105832992A/en active Pending
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| CN104825835A (en) * | 2015-04-25 | 2015-08-12 | 哈药集团中药二厂 | Preparation method of dendrobium nobile oral ulcer buccal tablet |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215073A (en) * | 2016-08-23 | 2016-12-14 | 哈药集团中药二厂 | A kind of preparation method of Fructus Alpiniae Oxyphyllae reducing urination sheet |
| CN106309623A (en) * | 2016-08-23 | 2017-01-11 | 哈药集团中药二厂 | Centella freckle removing chewable tablet preparing method |
| CN109832608A (en) * | 2017-11-28 | 2019-06-04 | 内蒙古伊利实业集团股份有限公司 | Alleviate the probiotics draft food compositions and its process for preparing buccal lozenge of throat discomfort |
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