CN108029768A - A kind of baby formula milk powder containing lactoferrin and probiotics and preparation method thereof - Google Patents
A kind of baby formula milk powder containing lactoferrin and probiotics and preparation method thereof Download PDFInfo
- Publication number
- CN108029768A CN108029768A CN201711229343.5A CN201711229343A CN108029768A CN 108029768 A CN108029768 A CN 108029768A CN 201711229343 A CN201711229343 A CN 201711229343A CN 108029768 A CN108029768 A CN 108029768A
- Authority
- CN
- China
- Prior art keywords
- powder
- milk powder
- vitamin
- premix
- lactoferrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000843 powder Substances 0.000 title claims abstract description 150
- 235000013336 milk Nutrition 0.000 title claims abstract description 76
- 210000004080 milk Anatomy 0.000 title claims abstract description 76
- 239000008267 milk Substances 0.000 title claims abstract description 76
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 title claims abstract description 71
- 102000010445 Lactoferrin Human genes 0.000 title claims abstract description 67
- 108010063045 Lactoferrin Proteins 0.000 title claims abstract description 67
- 235000021242 lactoferrin Nutrition 0.000 title claims abstract description 67
- 229940078795 lactoferrin Drugs 0.000 title claims abstract description 67
- 235000013350 formula milk Nutrition 0.000 title claims abstract description 65
- 239000006041 probiotic Substances 0.000 title claims abstract description 43
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 241001465754 Metazoa Species 0.000 claims abstract description 32
- 102000007544 Whey Proteins Human genes 0.000 claims abstract description 30
- 108010046377 Whey Proteins Proteins 0.000 claims abstract description 30
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 28
- 239000011707 mineral Substances 0.000 claims abstract description 28
- 241000186000 Bifidobacterium Species 0.000 claims abstract description 25
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 24
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims abstract description 24
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 23
- 235000019742 Vitamins premix Nutrition 0.000 claims abstract description 23
- 239000008101 lactose Substances 0.000 claims abstract description 23
- 239000002994 raw material Substances 0.000 claims abstract description 22
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims abstract description 19
- 125000003729 nucleotide group Chemical group 0.000 claims abstract description 19
- 239000000126 substance Substances 0.000 claims abstract description 19
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000005862 Whey Substances 0.000 claims abstract description 17
- 229960000367 inositol Drugs 0.000 claims abstract description 17
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims abstract description 17
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000002773 nucleotide Substances 0.000 claims abstract description 16
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- 229940114079 arachidonic acid Drugs 0.000 claims abstract description 12
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- 229910000019 calcium carbonate Inorganic materials 0.000 claims abstract description 12
- 239000001506 calcium phosphate Substances 0.000 claims abstract description 12
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 12
- 229940078499 tricalcium phosphate Drugs 0.000 claims abstract description 12
- 229910000391 tricalcium phosphate Inorganic materials 0.000 claims abstract description 12
- 235000019731 tricalcium phosphate Nutrition 0.000 claims abstract description 12
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims abstract description 11
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims abstract description 11
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims abstract description 11
- 238000000034 method Methods 0.000 claims abstract description 8
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- 238000013329 compounding Methods 0.000 claims description 38
- 235000010755 mineral Nutrition 0.000 claims description 27
- 230000001954 sterilising effect Effects 0.000 claims description 27
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 18
- 239000011734 sodium Substances 0.000 claims description 18
- 229910052708 sodium Inorganic materials 0.000 claims description 18
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 16
- 239000000463 material Substances 0.000 claims description 15
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims description 15
- 238000004659 sterilization and disinfection Methods 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 12
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 10
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims description 10
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 10
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 10
- 238000001704 evaporation Methods 0.000 claims description 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- 229940090949 docosahexaenoic acid Drugs 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 8
- 239000011647 vitamin D3 Substances 0.000 claims description 8
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- 239000011575 calcium Substances 0.000 claims description 6
- 229910052791 calcium Inorganic materials 0.000 claims description 6
- 239000011790 ferrous sulphate Substances 0.000 claims description 6
- 235000003891 ferrous sulphate Nutrition 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 claims description 6
- 229910000359 iron(II) sulfate Inorganic materials 0.000 claims description 6
- -1 nitric acid sulphur Amine Chemical class 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 5
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 5
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 5
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 5
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 5
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- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 5
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- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims description 5
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1522—Inorganic additives, e.g. minerals, trace elements; Chlorination or fluoridation of milk; Organic salts or complexes of metals other than natrium or kalium; Calcium enrichment of milk
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1528—Fatty acids; Mono- or diglycerides; Petroleum jelly; Paraffine; Phospholipids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/158—Milk preparations; Milk powder or milk powder preparations containing additives containing vitamins or antibiotics
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
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- Inorganic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a kind of baby formula milk powder containing lactoferrin and probiotics and preparation method thereof, which includes following raw material components：Whole-fat milk powder 20 40%,Desalted whey powder 20 45%,Lactose 0 18%,Maltodextrin 0 15%,Mixed vegetable oil 5 25%,Skimmed milk powder 0 12%,White granulated sugar 0 10%,Concentrated whey protein powder 1 8%,Phosphatidase 0 0.5%,Calcium carbonate 0.05 0.8%,Compound mineral substance premix 0.25 0.69%,Compound vitamin premix 0.06 0.07%,Arachidonic acid powder (AA) 0.1 1.8%,Docosahexaenoic acid (DHA) 0.005 1.5%,Inositol 0 0.09%,L L-carnitine-L-tartrates 0 0.08%,L sodium ascorbates 0.05 0.13%,Tricalcium phosphate 0 0.3%,Lactoferrin 0.01 0.1%,Animal bifidobacteria (Bb 12) 0.01 0.1%,Nucleotide 0.02 0.07%.Using baby formula milk powder made from the method for the present invention, nutritional ingredient imitates breast milk composition, meets the nutritional need of Normal Infants development, effectively improves the intestinal environment of infant, improves the immunity of infant.
Description
Technical field
The present invention relates to a kind of baby formula milk powder, more particularly to a kind of infant containing lactoferrin and probiotics to match somebody with somebody
Square milk powder and preparation method thereof.
Background technology
Breast-feeding is to grow to provide the best approach of ultimate food with developing for infantile health, it is to mother and baby
Health all has material impact.Yet with health status, need of work and other reasons, many mothers cannot or be reluctant with mother
Newborn feeding infant.The breastfeeding rate of various countries is generally reduced in the past 40 years, and majority all uses mixed feeding or artificial feeding.In order to
The healthy growth of these babies, the breast milk substitute using cow's milk as primary raw material --- the research of baby formula milk powder just enjoys
Pay attention to.
Past people replace the direct feeding infant of breast milk with cow's milk, but the inherent component presence of cow's milk and both breast milks is very big
Difference.Cow milk feeding cannot meet the needs of baby is to nutrition.Then people adjust its energy and nutrition on the basis of cow's milk
Element, is allowed to approach with breast milk, develops the nutritional need of suitable baby and the baby formula milk powder digested and assimilated.Such as China specially
Sharp publication No. is CN104206539A, and it discloses a kind of probiotics baby milk powder, in the baby formula milk powder, addition
Selective compound probiotic (animal bifidobacteria Bb-12, lactobacillus reuteri) and complex prebiotics are (oligofructose, low
Poly- galactolipin, polydextrose and polyfructosan)；Chinese patent publication No. is CN103621633A, and it discloses a kind of infant
Serial yak milk formula milk powder and preparation method thereof, in 1 section of addition bifidobacterium lactis Bi-07 of infant formula and animal bifidobacteria
Bb-12, in 2 sections of addition bifidobacterium lactis Bi-07 and Shu Li Tang lactobacillus LGGHN001 of infant formula, the addition of baby formulas milk powder
Bifidobacterium lactis Bi-07 and lactobacillus acidophilus NCFM.
But probiotics flora is made of a variety of strains in infant's enteron aisle.Research shows different prebioticses in enteron aisle
The promotion propagation species of beneficial bacterium is different, adds strain currently on the market and prebiotics species is more single, plus production and processing, storage
Transport and the in vivo all certain attenuation of the field planting quantity of gastric juice and bile to probiotics are deposited, final products are to infant to intestines
Road adjustment effect and unobvious.
In addition, lactoferrin is present in the milk of different mammals, its concentration is different with animal species, with milk
Compare, lactoferrin concentration highest in the milk of the mankind and other primates.Lactoferrin is the major protein of people's colostrum
One of matter, is that content is located at the second high main protein, the concentration change of lactoferrin is very greatly.With the concentration in colostrum most
Height, average concentration scope is 5~8g/L, and the concentration of transitional milk is reduced to 2~4g/L or lower.Dropped after two weeks in postpartum
Low to become apparent, into the milk of 2 years, lactoferrin content was relatively stablized after 1 month.
Lactoferrin is a kind of glycoprotein from transferrins family, due to lactoferrin dense in human milk and
Its important physiological function shown, particularly in the antimicrobial of Infant and neonates intestines and stomach, anti-inflammatory and immunoloregulation function,
People start to pay attention to and study its scientific meaning and application value.Lactoferrin because of its unique structure and biological function,
Strengthen body iron to absorb, to antipathogen, immunological regulation and anti-oxidant etc. play an important role.
Lactoferrin can reduce infant's respiratory disease.2007, King etc. carried out double blind random pair in the U.S.
According to experiment, the healthy formula milk of 4 weeks feeds youngster and is assigned to test group and control group (each 26) at random after 52 lifes, respectively
The formula milk containing 850mg/L and the bovine lactoferrin containing 102mg/L is taken in, after observing 1 year, it turns out that, test group and control
Group asthma prevalence is respectively 0.15 times/year and 0.50 times/year, and test group is substantially less than control group (P<0.05).
Lactoferrin can prevent infantile diarrhea.Ochoa is equal to 2013 has carried out one for 555 12 in Peru
The randomized controlled trial of~18 monthly age healthy infants.Test group 277, adds bovine lactoferrin twice, each 0.5g daily；
Placebo (placebo is maltodextrin) 278, is observed 6 months.It turns out that test group and placebo Incidence of Diarrhea
Respectively 6.6% and 7.0%；Test group and placebo diarrhea duration are respectively 4.76 days and 5.34 days, and middle severe takes off
Water incidence is respectively 1.0% and 2.6%, and test group is substantially less than placebo.
Research shows that lactoferrin can influence infant growth.Hernell et al. is to 59 ages 2 weeks~6
The health full term at monthly age, is assigned to breast-feeding group (16) and formula milk group, wherein being formulated according to its parent's wish
Milk powder group is divided into again to be strengthened 1 group of chalybeate (12, add iron 1.6mg/L), strengthens 2 groups of chalybeate (11, add iron 4mg/L), iron
Agent+lactoferrin group (10, add iron 1.8mg/L, and the wherein iron of 1.3mg is self-bonded the bovine lactoferrin of iron) and chalybeate+
Nucleotide group (10, addition iron 2.2mg/L and 40mg/L nucleotide), wherein the iron added is ferrous sulfate.Respectively at baby
Youngster 1,4 and height, weight, hemoglobin, serum levels of iron and total iron content are measured during 6 monthly age.It turns out that with breast-feeding group phase
Than addition bovine lactoferrin group height, weight and nutrition condition do not have difference.But bovine lactoferrin group baby is added at 4 monthly ages
It is significantly higher than 61.6 ± 2.3cm of baby of chalybeate+nucleotide group with the height 64.7 ± 2.3cm and 68.3 ± 2.5cm during 6 monthly age
With 66.5 ± 2.4cm (P<0.05)；At 6 monthly age, weight 8524 ± 1315g of chalybeate+lactoferrin group baby is also significantly high
In chalybeate+7461 ± 823g of nucleotide group；But in terms of infant's melt quality, on hemoglobin, serum levels of iron and total iron content,
No significant difference between each group.
Lactoferrin has antimicrobial property, i.e. antibacterial action.This main energy with its chelated iron from biological fluid
Power has section, plays antibacterial, antivirus action by the cell membrane for destroying microorganism, is that the body of baby is defendd.According to
The In vivo study of the progress such as Kruzel, 1h, which gives human lactoferrin, before lipopolysaccharides is injected to mouse can dramatically increase animal survival
Rate, giving lactoferrin processing in advance can make mortality of animals be reduced to 16.7% from 83.3%.Intestinal tissue pathological analysis knot
Fruit shows that the animal in advance through lactoferrin pretreatment has very strong resistance to infringement caused by lipopolysaccharides；Not with newborn iron
The animal of albumen processing, except Vacuole formation occurs for epithelium of intestinal mucosa, it was further observed that intestinal mucosa severe atrophy and oedema.
Therefore, it is necessary to the characteristic with reference to lactoferrin is improved innovation to existing probiotics baby milk powder, from
And improve intestinal environment, improve infant immunity.
The content of the invention
The present invention proposes that a kind of infant containing lactoferrin and probiotics matches somebody with somebody to solve the above problem of the prior art
Square milk powder and preparation method thereof.
The baby formula milk powder with the addition of vitamin, mineral matter that suitable infant grows needs based on cow's milk
And other alternative components, to develop the nutritional need that nutritional ingredient meets Normal Infants development, and mould as much as possible
The baby formula milk powder of imitative breast milk composition.
It using cow's milk and its product is main that baby formula milk powder provided by the invention containing lactoferrin and probiotics, which is,
Raw material, adds other raw-food materials and nutrition fortifier adjustment trophic component, simulates breast milk nutritional ingredient, compound using wet-dry change
The powder product that technique is process, eats suitable for Normal Infants, its energy and nutritional ingredient disclosure satisfy that infant just
Often need.
Inventive formulation with the addition of desalted whey powder, whole-fat milk powder, concentrated whey protein powder, mixed vegetable oil (soybean oil,
High oleic sunflower oil, corn oil, palm oil, coconut oil), lactose, docosahexaenoic acid powder (DHA), arachidonic acid powder
(AA), lactoferrin, probiotics (animal bifidobacteria Bb-12) and a variety of compounding dispensed food for baby nutrition fortifiers,
Power simulates the nutritional ingredient and structure of breast milk.By adding the nutritional ingredients such as DHA, AA and inositol, there is provided infant's nervous system
And the nutrient needed for retinal development；Lactoferrin is added, improves infant immunity, antibacterial, antiviral, prevention baby's abdomen
Rush down.Probiotics is added, helps to safeguard the intestinal flora balance of infant, forms the dominant microflora based on probiotics, promote
Intestinal health.
To achieve the above object, the present invention uses following technical scheme：
The first aspect of the invention is to provide a kind of baby formula milk powder containing lactoferrin and probiotics, by weight
Percentages, including following raw material components：Whole-fat milk powder 20-40%, desalted whey powder 20-45%, lactose 0-18%, malt paste
Smart 0-15%, mixed vegetable oil 5-25%, skimmed milk powder 0-12%, white granulated sugar 0-10%, concentrated whey protein powder 1-8%, phosphorus
Fat 0-0.5%, calcium carbonate 0.05-0.8%, compounding mineral substance premix 0.25-0.69%, compounding vitamin premix 0.06-
0.07%th, arachidonic acid powder (AA) 0.1-1.8%, docosahexaenoic acid (DHA) 0.005-1.5%, inositol 0-0.09%,
L- L-carnitine-L-tartrates 0-0.08%, L-AA sodium 0.05-0.13%, tricalcium phosphate 0-0.3%, lactoferrin
0.01-0.1%, animal bifidobacteria (Bb-12) 0.01-0.1%, nucleotide 0.02-0.07%.
Further, described containing in the baby formula milk powder of lactoferrin and probiotics, by weight percentage,
Including following raw material components：Whole-fat milk powder 23-39%, desalted whey powder 25-42%, lactose 0-15%, maltodextrin 0-10%,
Mixed vegetable oil 7-20%, skimmed milk powder 0-8%, white granulated sugar 0-8%, concentrated whey protein powder 1.5-5%, phosphatidase 0 .1-
0.3%th, calcium carbonate 0.1-0.4%, compounding mineral substance premix 0.25-0.69%, compounding vitamin premix 0.06-
0.07%th, arachidonic acid powder (AA) 0.5-1.2%, docosahexaenoic acid (DHA) 0.5-1.0%, inositol 0-0.05%, L-
L-carnitine-L-tartrate 0-0.05%, L-AA sodium 0.06-0.10%, tricalcium phosphate 0-0.1%, lactoferrin
0.02-0.08%, animal bifidobacteria (Bb-12) 0.02-0.08%, nucleotide 0.02-0.05%.
It is further preferred that it is used for infant formula of the 0-6 monthly ages containing lactoferrin and probiotics the present invention also provides a kind of
Milk powder, by weight percentage, including following raw material components：Whole-fat milk powder 23.5%, desalted whey powder 41.1%, lactose
11.7%th, mixed vegetable oil 18.6%, concentrated whey protein powder 1.5%, phosphatidase 0 .29%, calcium carbonate 0.29%, compounding mineral
Matter premix 0.69%, compounding vitamin premix 0.07%, arachidonic acid powder (AA) 0.90%, docosahexaenoic acid
(DHA) 0.86%, inositol 0.04%, L- L-carnitine-L-tartrates 0.02%, L-AA sodium 0.10%, tricalcium phosphate
0.1%th, lactoferrin 0.08%, animal bifidobacteria (Bb-12) 0.04%, nucleotide 0.04%.
It is further preferred that it is used for larger baby of the 6-12 monthly ages containing lactoferrin and probiotics the present invention also provides a kind of
Formula milk, by weight percentage, including following raw material components：Whole-fat milk powder 38.3%, desalted whey powder 31.4%, lactose
14.2%th, mixed vegetable oil 8.8%, concentrated whey protein powder 4.9%, phosphatidase 0 .30%, calcium carbonate 0.30%, compounding mineral matter
Premix 0.25%, compounding vitamin premix 0.06%, arachidonic acid powder (AA) 0.75%, docosahexaenoic acid
(DHA) 0.72%, inositol 0.04%, L- L-carnitine-L-tartrates 0.02%, L-AA sodium 0.08%, lactoferrin
0.08%th, animal bifidobacteria (Bb-12) 0.04%, nucleotide 0.04%.
It is further preferred that match somebody with somebody the present invention also provides a kind of for child of the 12-36 monthly ages containing lactoferrin and probiotics
Square milk powder, by weight percentage, including following raw material components：Whole-fat milk powder 34.5%, desalted whey powder 25.7%, malt paste
Essence 9.9%, mixed vegetable oil 7.9%, skimmed milk powder 7.9%, white granulated sugar 7.4%, concentrated whey protein powder 4.9%, phosphatide
0.30%th, calcium carbonate 0.30%, compounding mineral substance premix 0.25%, compounding vitamin premix 0.06%, arachidonic acid
Powder (AA) 0.50%, docosahexaenoic acid (DHA) 0.50%, inositol 0.04%, L- L-carnitine-L-tartrates 0.02%, L-
Sodium ascorbate 0.08%, lactoferrin 0.08%, animal bifidobacteria (Bb-12) 0.04%, nucleotide 0.04%.
Further, described containing in the baby formula milk powder of lactoferrin and probiotics, the mixed vegetable oil
For at least two in soybean oil, high oleic sunflower oil, corn oil, palm oil, coconut oil.
Further, described containing in the baby formula milk powder of lactoferrin and probiotics, the compounding mineral matter
Premix by mass percentage, including following raw material components：Potassium chloride 5~32%, sodium chloride 5~18%, copper sulphate 0.05
~0.80%, magnesium sulfate 5~15%, ferrous sulfate 8~46%, zinc sulfate 0.5~9.5%, manganese sulfate 0.1~1.0%, sub- selenium
Sour sodium 0~5.0%, sodium citrate 10~22%, lactose 10~25%.
Further, described containing in the baby formula milk powder of lactoferrin and probiotics, the compounding vitamin
Premix by mass percentage, including following raw material components：Retinol acetate (vitamin A) 5~17%, Vitamin D3 (dimension
Raw element D3) 2~13%, dl- α-D-α-tocopherol acetate (vitamin E) 25~40%, phytondione (vitamin K) 0.5~
5.0%th, Thiamin mononitrate (vitamin B1) 0.5~5.0%, riboflavin (vitamin B2) 0.05~3.00%, puridoxine hydrochloride
(vitamin B6) 0.5~4%, cyanocobalamin (vitamin B12) 0.5~5.0%, niacinamide 3~13%, folic acid 0.5~5.0%, D-
Calcium pantothenate 0.5~5.0%, biotin 0.5~5.0%, potassium iodide 0.5~5.0%, lactose 15~30%.
Further, described containing in the baby formula milk powder of lactoferrin and probiotics, the animal bifid bar
Bacterium (Bb-12) specification is 30IF (300 × 108Cfu/g), the total amount of adding of the animal bifidobacteria (Bb-12) is 0.5 × 107
~3 × 107Cfu/g, it is preferable that the total amount of adding of the animal bifidobacteria (Bb-12) is 1 × 107~2.5 × 107Cfu/g,
It is highly preferred that the total amount of adding of the animal bifidobacteria (Bb-12) is 1.8 × 107cfu/g。
The second aspect of the invention is to provide a kind of preparation method of the baby formula milk powder, specifically include as
Lower step：
Step 1, batch mixing：By whole-fat milk powder, desalted whey powder, concentrated whey protein powder, vegetable oil, lactose, phosphatide and carbon
Sour calcium uses 50~70 DEG C of pure water mixed dissolution, is sufficiently stirred；
Step 2, batch mixing：Mineral substance premix, compounding vitamin premix will be compounded respectively in each special container with 20
Times 30~40 DEG C of dissolved in purified water of amount, is added in the batch mixing of step 1) and is sufficiently mixed step by step, compounding mineral matter and multiple
>=10min is answered with vitamin addition incorporation time；
Step 3, homogeneous：The material that step 2) dissolving mixes is subjected to homogeneous, homogenization pressure is 20~22Mpa；
Step 4, pre-sterilizing：Material after step 3) homogeneous is subjected to pre-sterilizing, 80~90 DEG C of sterilization temperature, sterilizing time
16s, cooling, temporary, temporary 8~15 DEG C of temperature, temporary storage time≤4h；
Step 5, sterilization concentration：The material that step 4) is kept in is sent into vaporization chamber and carries out sterilization concentration, and sterilization temperature 87~
90 DEG C, sterilizing time 24s, 62~72 DEG C of an evaporating temperature of effect, two 46~56 DEG C of evaporating temperatures of effect, evaporating pressure -0.086~-
0.095Mpa, 0.05~0.02Mpa of sterilization pressure；16.0~21.0 ° of Be of discharge concentration；
Step 6, it is dry：Material after step 5) is concentrated is sent into drying tower through high-pressure pump, and process conditions are：Inlet air temperature
145~175 DEG C, 65~92 DEG C of temperature of outgoing air, negative pressure (- 0.5~-4.0) × 100pa, fluid bed negative pressure in tower：(- 0.5~-
3.5) × 100pa, one section of 30~85 DEG C of temperature, two sections of 5~55 DEG C of temperature, three sections of 5~35 DEG C of temperature, four sections of 5~30 DEG C of temperature,
15~30Mpa of high pressure pump pressure is spray-dried；And redrying is carried out by fluid bed and goes out powder, go out powder temperature≤38 DEG C,
Moisture≤4.0%, obtains original washing powder；
Step 7, premix：By animal bifidobacteria (Bb-12), docosahexaenoic acid, eicosatetraenoic acid, nucleotide,
L-cn, inositol, tricalcium phosphate, L-AA sodium, lactoferrin premix respectively according to additive amount；
Step 8, mix：Original washing powder is mixed with step 7) premix according to formula rate, obtains finished powder；
Step 9, pack, detect, storage.
Further, in the step 2) of the preparation method of the baby formula milk powder, dissolving compounding mineral matter is pre-
When batch mixing and compounding vitamin premix, first dissolving compounding mineral substance premix, is redissolved compounding vitamin premix after 10min
Material.
Further, in the step 7) of the preparation method of the baby formula milk powder, the animal bifidobacteria
(Bb-12), docosahexaenoic acid, eicosatetraenoic acid, nucleotide, l-cn, inositol, tricalcium phosphate, L-AA
Sodium, lactoferrin need to dilute through expanding before premix, expand dilution and are using the three-dimensional motion mixer of HS~10, motion frequency
35HZ, incorporation time 30s.
The present invention uses above-mentioned technical proposal, compared with prior art, has the following technical effect that：
Baby formula milk powder provided by the invention containing lactoferrin and probiotics, based on cow's milk, with the addition of suitable
Closing infant's growth needs containing lactoferrin, probiotics, vitamin, mineral matter and other alternative components, its nutritional ingredient
Breast milk composition is imitated, meets the nutritional need of Normal Infants development, effectively improves the intestinal environment of infant, is improved
The immunity of infant, is very suitable for Normal Infants and eats；And preparation method of the present invention is added using wet-dry change combination process
The powder product that work forms, saves energy consumption, reduces production cost, accelerates the production cycle.
Embodiment
The present invention is described in more detail below by specific embodiment, for a better understanding of the present invention,
But following embodiments are not intended to limit the scope of the invention.
Embodiment 1
Present embodiments provide it is a kind of be used for babies ' formula milk powder of the 0-6 monthly ages containing lactoferrin and probiotics, by weight
Percentages, including following raw material components：
Whole-fat milk powder 23.5%, desalted whey powder 41.1%, lactose 11.7%, mixed vegetable oil 18.6%, condensed whey
Albumen powder 1.5%, phosphatidase 0 .29%, calcium carbonate 0.30%, compounding mineral substance premix 0.36%, compounding vitamin premix
0.07%th, arachidonic acid powder (AA) 0.90%, docosahexaenoic acid (DHA) 0.86%, inositol 0.04%, L- l-cns
Tartrate 0.02%, L-AA sodium 0.10%, tricalcium phosphate 0.10%, lactoferrin 0.08%, animal bifidobacteria
(Bb-12) 0.04%, nucleotide 0.04%.
Wherein, mineral substance premix is compounded by mass percentage, including following raw material components：Potassium chloride 27%, chlorination
Sodium 12.8%, copper sulphate 0.13%, magnesium sulfate 10.5%, ferrous sulfate 13.2%, zinc sulfate 1.75%, manganese sulfate 0.15%,
Sodium selenite 0.57%, sodium citrate 14.4%, lactose 19.5%.
Compound vitamin premix by mass percentage, including following raw material components：Retinol acetate (vitamin A)
9.5%th, Vitamin D3 (vitamin D3) 6.5%, dl- α-D-α-tocopherol acetate (vitamin E) 34.1%, phytondione (dimension life
Plain K) 2.2%, Thiamin mononitrate (vitamin B1) 0.95%, riboflavin (vitamin B2) 0.28%, puridoxine hydrochloride (vitamin
B6) 0.91%, cyanocobalamin (vitamin B12) 2.96%, niacinamide 7.7%, folic acid 2.2%, D-VB5 calcium 2.7%, biotin
2.8%th, potassium iodide 2.0%, lactose 25.2%.Animal bifidobacteria (Bb-12) specification is 30IF, total amount of adding for 1 ×
107cfu/g。
The preparation method of the present embodiment, specifically includes following steps：
Step 1, batch mixing：By whole-fat milk powder, desalted whey powder, concentrated whey protein powder, vegetable oil, lactose, phosphatide and carbon
Sour calcium uses 50~70 DEG C of pure water mixed dissolution, is sufficiently stirred；
Step 2, batch mixing：Mineral substance premix, compounding vitamin premix will be compounded respectively in each special container with 20
Times 30~40 DEG C of dissolved in purified water of amount, is added in the batch mixing of step 1) and is sufficiently mixed step by step, compounding mineral matter and multiple
>=10min is answered with vitamin addition incorporation time；
Step 3, homogeneous：The material that step 2) dissolving mixes is subjected to homogeneous, homogenization pressure is 20~22Mpa；
Step 4, pre-sterilizing：Material after step 3) homogeneous is subjected to pre-sterilizing, 80~90 DEG C of sterilization temperature, sterilizing time
16s, cooling, temporary, temporary 8~15 DEG C of temperature, temporary storage time≤4h；
Step 5, sterilization concentration：The material that step 4) is kept in is sent into vaporization chamber and carries out sterilization concentration, and sterilization temperature 87~
90 DEG C, sterilizing time 24s, 62~72 DEG C of an evaporating temperature of effect, two 46~56 DEG C of evaporating temperatures of effect, evaporating pressure -0.086~-
0.095Mpa, 0.05~0.02Mpa of sterilization pressure；16.0~21.0 ° of Be of discharge concentration；
Step 6, it is dry：Material after step 5) is concentrated is sent into drying tower through high-pressure pump, and process conditions are：Inlet air temperature
145~175 DEG C, 65~92 DEG C of temperature of outgoing air, negative pressure (- 0.5~-4.0) × 100pa, fluid bed negative pressure in tower：(- 0.5~-
3.5) × 100pa, one section of 30~85 DEG C of temperature, two sections of 5~55 DEG C of temperature, three sections of 5~35 DEG C of temperature, four sections of 5~30 DEG C of temperature,
15~30Mpa of high pressure pump pressure is spray-dried；And redrying is carried out by fluid bed and goes out powder, go out powder temperature≤38 DEG C,
Moisture≤4.0%, obtains original washing powder；
Step 7, premix：By animal bifidobacteria (Bb-12), docosahexaenoic acid, eicosatetraenoic acid, nucleotide,
L-cn, inositol, tricalcium phosphate, L-AA sodium, lactoferrin premix respectively according to additive amount；
Step 8, mix：Original washing powder is mixed with step 7) premix according to formula rate, obtains finished powder；
Step 9, pack, detect, storage, testing result such as annex.
Embodiment 2
Present embodiments provide it is a kind of be used for larger babies ' formula milk powder of the 6-12 monthly ages containing lactoferrin and probiotics, press
Percentage by weight meter, including following raw material components：
Whole-fat milk powder 38.1%, desalted whey powder 31.3%, lactose 14.2%, mixed vegetable oil 8.8%, condensed whey egg
White powder 4.9%, phosphatidase 0 .30%, calcium carbonate 0.30%, compounding mineral substance premix 0.27%, compounding vitamin premix
0.06%th, arachidonic acid powder (AA) 0.75%, docosahexaenoic acid (DHA) 0.72%, inositol 0.04%, L- l-cns
Tartrate 0.02%, L-AA sodium 0.08%, lactoferrin 0.08%, animal bifidobacteria (Bb-12) 0.04%, core
Thuja acid 0.04%.
Wherein, mineral substance premix is compounded by mass percentage, including following raw material components：Potassium chloride 27%, chlorination
Sodium 12.8%, copper sulphate 0.13%, magnesium sulfate 10.5%, ferrous sulfate 13.2%, zinc sulfate 1.75%, manganese sulfate 0.15%,
Sodium selenite 0.57%, sodium citrate 14.4%, lactose 19.5%.
Compound vitamin premix by mass percentage, including following raw material components：
Retinol acetate (vitamin A) 9.5%, Vitamin D3 (vitamine D3) 6.5%, dl- α-D-α-tocopherol acetate (dimension lifes
Plain E) 34.1%, phytondione (vitamin K) 2.2%, Thiamin mononitrate (vitamin B1) 0.95%, riboflavin (vitamin
B2) 0.28%, puridoxine hydrochloride (vitamin B6) 0.91%, cyanocobalamin (vitamin B12) 2.96%, niacinamide 7.7%, folic acid
2.2%th, D-VB5 calcium 2.7%, biotin 2.8%, potassium iodide 2.0%, lactose 25.2%.Animal bifidobacteria (Bb-12) is advised
Lattice are 30IF, and total amount of adding is 1 × 107cfu/g。
The present embodiment is used for the preparation method of larger formula milk of the 6-12 monthly ages containing lactoferrin and probiotics with implementation
Example 1 is identical, and the larger babies ' formula milk powder containing lactoferrin and probiotics for 6-12 monthly ages larger baby is made.
Embodiment 3
It is used for baby formulas milk powder of the 12-36 monthly ages containing lactoferrin and probiotics the present embodiment provides a kind of, by weight
Percentages, including following raw material components：Whole-fat milk powder 34.2%, desalted whey powder 25.5%, maltodextrin 9.9%, mixing
Vegetable oil 7.9%, skimmed milk powder 7.9%, white granulated sugar 7.4%, concentrated whey protein powder 4.9%, phosphatidase 0 .30%, calcium carbonate
0.30%th, compound mineral substance premix 0.34%, compounding vitamin premix 0.06%, arachidonic acid powder (AA) 0.50%,
Docosahexaenoic acid (DHA) 0.50%, inositol 0.04%, L- L-carnitine-L-tartrates 0.02%, L-AA sodium
0.08%th, lactoferrin 0.08%, animal bifidobacteria (Bb-12) 0.04%, nucleotide 0.04%.
Wherein, mineral substance premix is compounded by mass percentage, including following raw material components：Potassium chloride 27%, chlorination
Sodium 12.8%, copper sulphate 0.13%, magnesium sulfate 10.5%, ferrous sulfate 13.2%, zinc sulfate 1.75%, manganese sulfate 0.15%,
Sodium selenite 0.57%, sodium citrate 14.4%, lactose 19.5%.
Compound vitamin premix by mass percentage, including following raw material components：Retinol acetate (vitamin A)
9.5%th, Vitamin D3 (vitamin D3) 6.5%, dl- α-D-α-tocopherol acetate (vitamin E) 34.1%, phytondione (dimension life
Plain K) 2.2%, Thiamin mononitrate (vitamin B1) 0.95%, riboflavin (vitamin B2) 0.28%, puridoxine hydrochloride (vitamin
B6) 0.91%, cyanocobalamin (vitamin B12) 2.96%, niacinamide 7.7%, folic acid 2.2%, D-VB5 calcium 2.7%, biotin
2.8%th, potassium iodide 2.0%, lactose 25.2%.Animal bifidobacteria (Bb-12) specification is 30IF, total amount of adding for 1 ×
107cfu/g。
The same embodiment of preparation method of the present embodiment baby formulas milk powder of the 12-36 monthly ages containing lactoferrin and probiotics
1 is identical, and the baby formulas milk powder containing lactoferrin and probiotics for 12-36 monthly age childs is made.
Quality testing is reported：
Choose embodiment 1 and be used for the 0-6 monthly ages containing lactoferrin and the progress quality testing of the babies ' formula milk powder of probiotics, tool
Body testing result is as shown in table 1 below：
1 testing result of table, product nutrient composition content
Tracking of products is evaluated：
First, testing program
According to《Baby formula milk powder nutrition, safe tracking evaluation scheme》, to containing breast made from 1-3 of the embodiment of the present invention
Ferritin and the baby formula milk powder product of probiotics are paid a return visit, tracking evaluation its trophism, security and product sensory
Characteristic, wherein babies ' formula milk powder, larger babies ' formula milk powder, baby formulas milk powder pay a return visit number and are no less than 5 people respectively.
2nd, result and conclusion are paid a return visit
It is produced by the present invention as follows containing lactoferrin and the baby formula milk powder of probiotics return visit result：
Table 2：Embodiment 1 is made pays a return visit result containing lactoferrin and the babies ' formula milk powder of probiotics
From statistical result in table 2：During the edible babies ' formula milk powder containing lactoferrin and probiotics, Ying Ershen
The development of long and weight is normal, has good resistance；Do not occur the adverse reactions such as excessive internal heat, constipation, allergy/eczema, only 1
It is a to pay a return visit the mild diarrhea of object appearance once in a while once, and 1,2 day just gets well, and excludes the influence of milk powder, therefore milk powder
With good trophism and security；The structural state of milk powder is normal, and taste smell is normal frankincense, but has 1 return visit object
Because reconstituting, method is seriously improper, so that there is the phenomenon of brew difference, therefore brew is normal, and acceptance level is normal or fine,
With good product sensory characteristic.
Table 3：Embodiment 2 pays a return visit result containing lactoferrin and the larger babies ' formula milk powder of probiotics
From statistical result in table 3：During the edible larger babies ' formula milk powder containing lactoferrin and probiotics, compared with
Big baby's height and weight development are normal, have good resistance；Do not occur the adverse reactions such as excessive internal heat, constipation, there is 1 to return
Object mild diarrhea once in a while, 1 return visit object slight allergy, but get well quickly once in a while are visited, therefore excludes the influence of milk powder,
Therefore milk powder has good trophism and security；Milk powder structural state is normal, grows the normal frankincense of smell, brew it is normal or
Very well, acceptance level is fine, has good product sensory characteristic.
Table 4：Embodiment 3 pays a return visit result containing lactoferrin and the baby formulas milk powder of probiotics
From statistical result in table 4：During the edible baby formulas milk powder containing lactoferrin and probiotics, You Ershen
The development of long and weight is normal, has good resistance；Do not occur the adverse reactions such as allergy, eczema, there is 1 to pay a return visit object and exist
Turn occur mild diarrhea during milk, pay a return visit object for 1 and occur slight constipation once in a while, therefore exclude the influence of milk powder, therefore milk powder has
Good trophism and security；The structural state of milk powder is normal, grows the normal frankincense of smell, brew is normal or fine, receives
Degree is normal or fine, has good product sensory characteristic.
Conclusion：In conclusion the baby formula milk powder eating condition of the invention containing lactoferrin and probiotics is good, tool
There are good trophism, security and product sensory characteristic.
The specific embodiment of the present invention is described in detail above, but it is intended only as example, it is of the invention and unlimited
It is formed on particular embodiments described above.To those skilled in the art, it is any to the equivalent modifications that carry out of the present invention and
Substitute also all among scope of the invention.Therefore, the impartial conversion made without departing from the spirit and scope of the invention and
Modification, all should be contained within the scope of the invention.
Claims (9)
- A kind of 1. baby formula milk powder containing lactoferrin and probiotics, it is characterised in that by weight percentage, including with Lower raw material components：Whole-fat milk powder 20-40%, desalted whey powder 20-45%, lactose 0-18%, maltodextrin 0-15%, mixing are planted Thing oil 5-25%, skimmed milk powder 0-12%, white granulated sugar 0-10%, concentrated whey protein powder 1-8%, phosphatidase 0-0.5%, calcium carbonate 0.05-0.8%, compounding mineral substance premix 0.25-0.69%, compounding vitamin premix 0.06-0.07%, arachidonic acid Powder (AA) 0.1-1.8%, docosahexaenoic acid (DHA) 0.005-1.5%, inositol 0-0.09%, L- L-Carnitine tartrate Salt 0-0.08%, L-AA sodium 0.05-0.13%, tricalcium phosphate 0-0.3%, lactoferrin 0.01-0.1%, animal are double Discrimination bacillus (Bb-12) 0.01-0.1%, nucleotide 0.02-0.07%.
- 2. baby formula milk powder according to claim 1, it is characterised in that by weight percentage, including following original Expect component：Whole-fat milk powder 23-39%, desalted whey powder 25-42%, lactose 0-15%, maltodextrin 0-10%, mixed vegetable oil 7-20%, skimmed milk powder 0-8%, white granulated sugar 0-8%, concentrated whey protein powder 1.5-5%, phosphatidase 0 .1-0.3%, calcium carbonate 0.1-0.4%, compounding mineral substance premix 0.25-0.69%, compounding vitamin premix 0.06-0.07%, arachidonic acid Powder (AA) 0.5-1.2%, docosahexaenoic acid (DHA) 0.5-1.0%, inositol 0-0.05%, L- L-carnitine-L-tartrate 0-0.05%, L-AA sodium 0.06-0.10%, tricalcium phosphate 0-0.1%, lactoferrin 0.02-0.08%, animal bifid Bacillus (Bb-12) 0.02-0.08%, nucleotide 0.02-0.05%.
- 3. baby formula milk powder according to claim 1 or 2, it is characterised in that the mixed vegetable oil for soybean oil, At least two in high oleic sunflower oil, corn oil, palm oil, coconut oil.
- 4. baby formula milk powder according to claim 1 or 2, it is characterised in that the compounding mineral substance premix is pressed Mass percent meter, including following raw material components：Potassium chloride 5~32%, sodium chloride 5~18%, copper sulphate 0.05~0.80%, Magnesium sulfate 5~15%, ferrous sulfate 8~46%, zinc sulfate 0.5~9.5%, manganese sulfate 0.1~1.0%, sodium selenite 0~ 5.0%th, sodium citrate 10~22%, lactose 10~25%.
- 5. baby formula milk powder according to claim 1 or 2, it is characterised in that the compounding vitamin premix is pressed Mass percent meter, including following raw material components：Retinol acetate (vitamin A) 5~17%, Vitamin D3 (vitamin D3)2 ~13%, dl- α-D-α-tocopherol acetate (vitamin E) 25~40%, phytondione (vitamin K) 0.5~5.0%, nitric acid sulphur Amine element (vitamin B1) 0.5~5.0%, riboflavin (vitamin B2) 0.05~3.00%, puridoxine hydrochloride (vitamin B6)0.5 ~4%, cyanocobalamin (vitamin B12) 0.5~5.0%, niacinamide 3~13%, folic acid 0.5~5.0%, D-VB5 calcium 0.5~ 5.0%th, biotin 0.5~5.0%, potassium iodide 0.5~5.0%, lactose 15~30%.
- 6. baby formula milk powder according to claim 1 or 2, it is characterised in that the animal bifidobacteria (Bb-12) Specification is 30IF (300 × 108Cfu/g), the total amount of adding of the animal bifidobacteria (Bb-12) is 0.5 × 107~3 × 107cfu/g。
- It is 7. a kind of such as the preparation method of claim 1-6 any one of them baby formula milk powders, it is characterised in that including such as Lower step：Step 1, batch mixing：By whole-fat milk powder, desalted whey powder, concentrated whey protein powder, vegetable oil, lactose, phosphatide and calcium carbonate Using 50~70 DEG C of pure water mixed dissolution, it is sufficiently stirred；Step 2, batch mixing：Mineral substance premix, compounding vitamin premix will be compounded respectively in each special container with 20 times of amounts 30~40 DEG C of dissolved in purified water, is added in the batch mixing of step 1) and is sufficiently mixed step by step, and compounding mineral matter and compounding are tieed up Raw element addition incorporation time answers >=10min；Step 3, homogeneous：The material that step 2) dissolving mixes is subjected to homogeneous, homogenization pressure is 20~22Mpa；Step 4, pre-sterilizing：By after step 3) homogeneous material carry out pre-sterilizing, 80~90 DEG C, sterilizing time 16s of sterilization temperature, Cooling, temporary, temporary 8~15 DEG C of temperature, temporary storage time≤4h；Step 5, sterilization concentration：The material that step 4) is kept in is sent into vaporization chamber and carries out sterilization concentration, 87~90 DEG C of sterilization temperature, Sterilizing time 24s, 62~72 DEG C of an evaporating temperature of effect, two 46~56 DEG C of evaporating temperatures of effect, evaporating pressure -0.086~- 0.095Mpa, 0.05~0.02Mpa of sterilization pressure；16.0~21.0 ° of Be of discharge concentration；Step 6, it is dry：Material after step 5) is concentrated is sent into drying tower through high-pressure pump, and process conditions are：Inlet air temperature 145 ~175 DEG C, 65~92 DEG C of temperature of outgoing air, negative pressure (- 0.5~-4.0) × 100pa, fluid bed negative pressure in tower：(- 0.5~-3.5) × 100pa, one section of 30~85 DEG C of temperature, two sections of 5~55 DEG C of temperature, three sections of 5~35 DEG C of temperature, four sections of 5~30 DEG C of temperature, high pressure 15~30Mpa of pump pressure is spray-dried；And redrying is carried out by fluid bed and goes out powder, go out powder temperature≤38 DEG C, moisture ≤ 4.0%, obtain original washing powder；Step 7, premix：By animal bifidobacteria (Bb-12), docosahexaenoic acid, eicosatetraenoic acid, nucleotide, left-handed Carnitine, inositol, tricalcium phosphate, L-AA sodium, lactoferrin premix respectively according to additive amount；Step 8, mix：Original washing powder is mixed with step 7) premix according to formula rate, obtains finished powder；Step 9, pack, detect, storage.
- 8. the preparation method of baby formula milk powder according to claim 1, it is characterised in that in step 2), dissolving is multiple When with mineral substance premix and compounding vitamin premix, first dissolving compounding mineral substance premix, is redissolved compounding after 10min Vitamin premix.
- 9. the preparation method of baby formula milk powder according to claim 1, it is characterised in that described dynamic in step 7) Thing Bifidobacterium (Bb-12), docosahexaenoic acid, eicosatetraenoic acid, nucleotide, l-cn, inositol, tricalcium phosphate, L-AA sodium, lactoferrin need to dilute through expanding before premix, expand dilution using the three-dimensional motion mixer of HS~10, Motion frequency is 35HZ, incorporation time 30s.
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| CN115669734A (en) * | 2021-07-30 | 2023-02-03 | 金可澳电子商务(上海)有限公司 | Infant formula milk powder and preparation method thereof |
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| CN115989836A (en) * | 2022-11-29 | 2023-04-21 | 黑龙江飞鹤乳业有限公司 | Nutritional composition containing lactoferrin and probiotics, food and application |
| CN116114762A (en) * | 2022-12-19 | 2023-05-16 | 光明乳业股份有限公司 | Formula milk powder and production process thereof |
| CN116076578A (en) * | 2023-03-22 | 2023-05-09 | 北大荒完达山乳业股份有限公司 | Infant formula milk powder containing alpine ecological cow milk compound fat and preparation method thereof |
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