CN104206539A - Probiotic-containing infant milk powder - Google Patents
Probiotic-containing infant milk powder Download PDFInfo
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- CN104206539A CN104206539A CN201410400017.6A CN201410400017A CN104206539A CN 104206539 A CN104206539 A CN 104206539A CN 201410400017 A CN201410400017 A CN 201410400017A CN 104206539 A CN104206539 A CN 104206539A
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Abstract
The purpose of the invention is providing a probiotic-containing infant milk powder. The probiotic-containing infant milk powder comprises 10-40 parts of lactose, 10-40 parts of demineralized whey powder, 5-25 parts of skimmed milk powder, 0-12 parts of whey protein concentrate, 1-4.5 parts of composite probiotic, 0.5-2.5 parts of mineral matter premix, 0.3-1.8 parts of arachidonic acid submicron powder and 0.05-0.4 parts of composite probiotic lyophilized powder. The composite probiotic lyophilized powder contains 1*10<7>-1*10<9>CFU/g of Lactobacillus reuteri with the strain number of DSM17938 and 0-1*10<8>CFU/g of Bifidobacterium animalis with the strain number of Bb~12. The probiotic-containing infant milk powder is suitable for infants, can adjust the intestinal flora balance of the infants, promote the intestinal patency, inhibit diarrhea and improve the immunity of the infants, and has the advantages of reasonable formula, synergistic effect of all components, and good effect.
Description
Technical field
The present invention relates to field of food, especially, relate to a kind of probio baby milk powder.
Background technology
The definition of probio is " the microorganism dietary supplements of be of value to host health, living ".Probio is used for human or animal, when reaching enough dosage, by improving balance and the performance of enteric microorganism, thus beneficial effect produced to host, enteron aisle is unobstructed as promoted, improve intestinal environment, suppress diarrhoea, alleviate lactose intolerance, improve immunity etc.
Probio for human body needs to have following character: (1) is from human body; (2) to stability that is sour and bile; (3) people's intestinal cell and intestinal mucosa glycoprotein is sticked to; (4) competitive exclusion and field planting in people's enteron aisle; (5) antimicrobial material is produced; (6) anti-microbial pathogen; (7) security in food and remedy diet; (8) clinical accreditation and proof health effect.Probio industrially especially needs the probio using acid resistance good, guarantees to arrive enteron aisle through the sour environment of stomach with enough amounts, and can at stomach Growth and reproduction.
Lactobacillus reuteri (Lactobacillus reuteri) is that Russian biologist EliMetchnikoff has found a kind of lactic acid producing bacteria in 1908 from Bulgarian and Russ fermented dairy product, be accredited as lactobacillus acidophilus (Lactobacillus acidophilus) afterwards, it is the one that the habit of the natural generation of animal gastrointestinal tract occupies in bacterium, and be typically found at healthy animal, comprise in the enteron aisle of people.
Lactobacillus reuteri is gained the name because it produces lactic acid ability, and producing lactic acid is only the one of spreading out in this kind of bacteriogenic many benefits; It can bear the effect of hydrochloric acid in gastric juice and bile and arrive small intestine, and extracellular exists adhesin, to the mucous membrane mucus of host and the stronger Adhering capacity of Intestinal epithelial cells bacterium performance; Lactobacillus reuteri possesses the main beneficial functional of Bacillus acidi lactici, also possesses the special efficacy producing broad-spectrum antiseptic material; Lactobacillus reuteri and Bifidobacterium synbiosis can accelerate host intestine microorganism and recover its original kilter, thus regulate the flora stable state in acute diarrhea Intestinal Mucosal Injury in Patients Undergoing, promote intestinal health, unobstructed.
Lactobacillus reuteri DSM17938 is obtained from lactobacillus reuteri ATCC55730 by elimination two plasmid pLR581 and pLR585.It and ATCC55730 have that identical rep ~ PCR schemes, fermentation pattern, reuterin production, form, growth rate, mucus adhesiveness and Bile tolerance, but than parental plant to tetracycline and cillimycin more responsive.The lactobacillus reuteri DSM17938 viable count taken in is higher than 1 × 10
7during CFU/g, it can have obvious facilitation to health.
Prebiotics by optionally stimulating the growth of a kind of or a few bacterium in colon or active and produce beneficial effect to host, can strengthen viability and the multiplication capacity of probio widely by adding prebiotics selectively.
In baby formula milk powder, be added with optionally compound probiotic and complex prebiotics, intestinal health is maintained to help infant, promote that enteron aisle is unobstructed, improve immunity of organisms etc., there is important function and significance.
Summary of the invention
The first object of the present invention is that providing a kind of can adjust infant's gut flora balance, suppresses diarrhoea and improve the probio baby milk powder of infant immunity, and concrete technical scheme is as follows:
A kind of probio baby milk powder, with weight parts, raw material comprises following component: lactose 10 ~ 40 parts, vegetable oil 21 ~ 29 parts, desalted whey powder 10 ~ 40 parts, skimmed milk power 5 ~ 25 parts, concentrated whey protein powder 0 ~ 12 part, complex prebiotics 1 ~ 4.5 part, mineral substance premix 0.5 ~ 2.5 part, arachidonic acid Ultramicro-powder 0.3 ~ 1.8 part, DHA Ultramicro-powder 0.2 ~ 1.8 part, vitamin premix 0.1 ~ 0.5 part, compound probiotic freeze-dried powder 0.04 ~ 0.4 part, lactoferrin 0 ~ 0.10 part, VBT 0.01 ~ 0.03 part, taurine 0.02 ~ 0.05 part and 0.015 ~ 0.055 part, nucleotides,
In described arachidonic acid Ultramicro-powder, the mass percentage of ARA is more than or equal to 10%;
In described DHA Ultramicro-powder, the mass percentage of DHA is more than or equal to 7%;
Described compound probiotic freeze-dried powder comprises lactobacillus reuteri and animal bifidobacteria, and the bacterial strain number of described lactobacillus reuteri is DSM17938, and its content is 1 × 10
7~ 1 × 10
9cFU/g; The bacterial strain number of described animal bifidobacteria is Bb ~ 12, and its content is 0 ~ 1 × 10
8cFU/g.
Preferred in above technical scheme, described vegetable oil comprises at least three kinds in sunflower oil, coconut oil, soybean oil, Canola Oil, palm oil and palm-kernel oil;
Following raw material components is comprised in mass fraction: potassium chloride 28 ~ 38%, natrium citricum 20 ~ 28%, tricalcium phosphate 15 ~ 25%, magnesium sulfate 8 ~ 15%, calcium carbonate 3 ~ 8%, ferrous sulfate 0.6 ~ 1.5%, zinc sulfate 0.5 ~ 1.2%, copper sulphate 0.05 ~ 0.15%, manganese sulfate 0.01 ~ 0.05%, KI 0.005 ~ 0.015% and sodium selenite 0.0015 ~ 0.0035% in described mineral substance premix;
Following raw material components is comprised in mass fraction: L-AA sodium 38 ~ 48% in described vitamin premix, Choline Chloride 23 ~ 33%, inositol 12 ~ 22%, dl-α-D-α-tocopherol acetate 5 ~ 10%, niacinamide 1.0 ~ 3.0%, D-VB5 calcium 1.0 ~ 3.0%, riboflavin 0.3 ~ 1.0%, thiamine hydrochloride 0.2 ~ 0.8%, axerophtholum aceticum 0.1 ~ 0.6%, puridoxine hydrochloride 0.1 ~ 0.5%, folic acid 0.01 ~ 0.10%, phytondione 0.01 ~ 0.05%, Bio 0.008 ~ 0.03%, vitamine D3 0.002 ~ 0.007% and cyanocobalamin 0.001 ~ 0.003%,
Described complex prebiotics comprises at least one in FOS, galactooligosaccharide, polydextrose and polyfructosan.
Preferred in above technical scheme, the content proportioning of described lactobacillus reuteri and described animal bifidobacteria is 1:1.
Preferred in above technical scheme, with weight parts, raw material comprises following component:
Lactose 32.6 parts, vegetable oil 25.8 parts, desalted whey powder 16.8 parts, skimmed milk power 10.9 parts, concentrated whey protein powder 6.6 parts, complex prebiotics 3.5 parts, mineral substance premix 1.5 parts, arachidonic acid Ultramicro-powder 1.0 parts, DHA Ultramicro-powder 0.81 part, vitamin premix 0.24 part, compound probiotic freeze-dried powder 0.08 part, lactoferrin 0.08 part, VBT 0.02 part, taurine 0.04 part and 0.03 part, nucleotides;
Following raw material components is comprised in mass fraction: potassium chloride 35.5%, natrium citricum 24.4%, tricalcium phosphate 21.1%, magnesium sulfate 12.5%, calcium carbonate 4.8%, ferrous sulfate 0.88%, zinc sulfate 0.72%, copper sulphate 0.065%, manganese sulfate 0.025%, KI 0.0076% and sodium selenite 0.0024% in described mineral substance premix;
Following raw material components is comprised in mass fraction: L-AA sodium 43.1%, Choline Chloride 28.8%, inositol 16.7%, dl-α-D-α-tocopherol acetate 7.1%, niacinamide 1.8%, D-VB5 calcium 1.08%, riboflavin 0.41%, thiamine hydrochloride 0.33%, axerophtholum aceticum 0.30%, puridoxine hydrochloride 0.31%, folic acid 0.03%, phytondione 0.025%, Bio 0.010%, vitamine D3 0.004% and cyanocobalamin 0.001% in described vitamin premix;
In described complex prebiotics, the mass ratio of FOS and galactooligosaccharide is 2:8.
Preferred in above technical scheme, the content proportioning of described lactobacillus reuteri and described animal bifidobacteria is 3:1.
Preferred in above technical scheme, with weight parts, raw material comprises following component:
Lactose 29.3 parts, vegetable oil 25.8 parts, desalted whey powder 20.1 parts, skimmed milk power 12.2 parts, concentrated whey protein powder 5.5 parts, complex prebiotics 2.5 parts, mineral substance premix 1.3 parts, arachidonic acid Ultramicro-powder 1.5 parts, DHA Ultramicro-powder 1.2 parts, vitamin premix 0.23 part, compound probiotic freeze-dried powder 0.2 part, lactoferrin 0.05 part, VBT 0.03 part, taurine 0.03 part and 0.02 part, nucleotides;
Following raw material components is comprised in mass fraction: potassium chloride 30.5%, natrium citricum 26.6%, tricalcium phosphate 22.4%, magnesium sulfate 13.5%, calcium carbonate 5.5%, ferrous sulfate 0.73%, zinc sulfate 0.65%, copper sulphate 0.0755%, manganese sulfate 0.037%, KI 0.0056% and sodium selenite 0.0019% in described mineral matter;
Following raw material components is comprised in mass fraction: L-AA sodium 39.1% in described vitamin premix, Choline Chloride 32.3%, inositol 18.3%, dl-α-D-α-tocopherol acetate 5.1%, niacinamide 2.1%, D-VB5 calcium 1.51%, riboflavin 0.52%, thiamine hydrochloride 0.45%, axerophtholum aceticum 0.27%, puridoxine hydrochloride 0.29%, folic acid 0.023%, phytondione 0.024%, Bio 0.008%, vitamine D3 0.004% and cyanocobalamin 0.001%,
In described complex prebiotics, the mass ratio of FOS and galactooligosaccharide is 9:1.
Preferred in above technical scheme, the content proportioning of described lactobacillus reuteri and described animal bifidobacteria is 8:1.
Preferred in above technical scheme, with weight parts, raw material comprises following component:
Lactose 31 parts, vegetable oil 24 parts, desalted whey powder 20 parts, skimmed milk power 9 parts, concentrated whey protein powder 7.2 parts, complex prebiotics 4.2 parts, mineral substance premix 1.74 parts, arachidonic acid Ultramicro-powder 1.03 parts, DHA Ultramicro-powder 1.03 parts, vitamin premix 0.25 part, compound probiotic freeze-dried powder 0.25 part, lactoferrin 0.09 part, VBT 0.028 part, taurine 0.037 part and 0.045 part, nucleotides;
Following raw material components is comprised in mass fraction: potassium chloride 32.8%, natrium citricum 27.2%, tricalcium phosphate 18.2%, magnesium sulfate 13.39%, calcium carbonate 7.1%, ferrous sulfate 0.64%, zinc sulfate 0.58%, copper sulphate 0.053%, manganese sulfate 0.027%, KI 0.0069% and sodium selenite 0.0031% in described mineral substance premix;
Following raw material components is comprised in mass fraction: L-AA sodium 36.8%, Choline Chloride 32.9%, inositol 17.7%, dl-α-D-α-tocopherol acetate 5.7%, niacinamide 2.5%, D-VB5 calcium 2.60%, riboflavin 0.52%, thiamine hydrochloride 0.41%, axerophtholum aceticum 0.30%, puridoxine hydrochloride 0.45%, folic acid 0.09%, phytondione 0.011%, Bio 0.015%, vitamine D3 0.003% and cyanocobalamin 0.001% in described vitamin premix;
The mass ratio of FOS, galactooligosaccharide, polydextrose described in described complex prebiotics is 1:1:8.
Preferred in above technical scheme, described vegetable oil comprises sunflower oil, coconut oil and soybean oil.
Adopt the formula of probio baby milk powder of the present invention, there is following beneficial effect: (1) is passed through on purpose to add compound probiotic, when may be used for the field planting of neonate's bacterium colony, the foundation of beneficial bacterium advantage; (2) by the interaction of compound probiotic, adjustment infant gut flora balance, the immunity suppressing diarrhoea, improve infant; (3) by purpose adding complex prebiotics, greatly can strengthen viability and the reproductive capacity of probio, maintaining the advantage of beneficial bacterium at gut flora; (4) kind of each material and the selection of dosage in the formula of probio baby milk powder of the present invention, make, between each component, there is certain synergy, play optimum efficiency, specific as follows: the two kind important nutrient of DHA and ARA needed for infant's brain development, in ripe breast milk, the ratio of ARA and DHA is about 1.8, in the present invention program, the content of DHA and ARA can ensure that infant's growth course deutocerebrum grows the demand to it, promotes brain development; Taurine is that infant's growth course deutocerebrum is grown and retina forms necessary nutrient, and in the present invention program, the consumption of taurine can guarantee the demand to it, promotes the growth of brain and amphiblestroid formation; Lactoferrin can suppress harmful microbe growth and breeding in human body; Nucleotides can promote the growth and breeding of gut maturation and Bifidobacterium; Add prebiotics containing in the product of profitable probliotics, the viable count in product can be made to increase and extend shelf life, thus cause the number of viable cells of the beneficial bacterium taken in increase; The simultaneously existence of prebiotics not only facilitates growth and the activity of the probio of outer clothes, also can the growth of beneficial bacteria that exists of selective promotion enteron aisle itself and activity; Bifidobacterium, lactobacillus are the modal two kinds of probios of human body intestinal canal, and wherein animal bifidobacteria is mainly colonizated in large intestine, and Lactobacillus rogosae has stronger bile tolerance performance, can be colonizated in small intestine, large intestine; Both use simultaneously, better effects if.
Except object described above, feature and advantage, object, feature and advantage that the present invention also has other possibility potential.
Detailed description of the invention
Be described in detail below in conjunction with embodiment, but the multitude of different ways that the present invention can limit according to claim and cover is implemented.
Embodiment 1:
A kind of probio baby milk powder, raw material comprises following component:
Lactose 32.6 kilograms, vegetable oil 25.8 kilograms, desalted whey powder 16.8 kilograms, skimmed milk power 10.9 kilograms, concentrated whey protein powder 6.6 kilograms, complex prebiotics 3.5 kilograms, mineral substance premix 1.5 kilograms, arachidonic acid Ultramicro-powder 1.0 kilograms, DHA Ultramicro-powder 0.81 kilogram, vitamin premix 0.24 kilogram, compound probiotic freeze-dried powder 0.08 kilogram, lactoferrin 0.08 kilogram, taurine 0.04 kilogram, 0.030 kilogram, nucleotides and VBT 0.02 kilogram.
Wherein, following raw material components is comprised in mass fraction in described mineral substance premix: potassium chloride 35.5%, natrium citricum 24.4%, tricalcium phosphate 21.1%, magnesium sulfate 12.5%, calcium carbonate 4.8%, ferrous sulfate 0.88%, zinc sulfate 0.72%, copper sulphate 0.065%, manganese sulfate 0.025%, KI 0.0076% and sodium selenite 0.0024%.
Following raw material components is comprised in mass fraction: L-AA sodium 43.1%, Choline Chloride 28.8%, inositol 16.7%, dl-α-D-α-tocopherol acetate 7.1%, niacinamide 1.8%, D-VB5 calcium 1.08%, riboflavin 0.41%, axerophtholum aceticum 0.30%, thiamine hydrochloride 0.33%, puridoxine hydrochloride 0.31%, folic acid 0.03%, phytondione 0.025%, Bio 0.010%, vitamine D3 0.004% and cyanocobalamin 0.001% in described vitamin premix.
In described compound probiotic freeze-dried powder: the bacterial strain number of described lactobacillus reuteri is DSM17938, and its content is 1 × 10
7cFU/g; The bacterial strain number of described animal bifidobacteria is Bb ~ 12, and its content is 1 × 10
7cFU/g.
In described complex prebiotics, the mass ratio of FOS and galactooligosaccharide is 2:8.
Described vegetable oil comprises sunflower oil, coconut oil and soybean oil.
The preparation method of the present embodiment probio baby milk powder is as follows:
The first step: batching, by fresh cow milk pasteurize 20 seconds under temperature is 72 DEG C of conditions, then sloughs fat and obtains skim milk, take the skim milk of the equal total dry solids weight of formula skimmed milk power; The lactose, desalted whey powder, concentrated whey protein powder, complex prebiotics, mineral substance premix, water miscible vitamin premix, taurine and the VBT that take by predetermined ratio respectively add in skim milk and mix again, and are transferred to temporary storage tank I; Take vegetable oil by predetermined ratio and fat-soluble vitamin premix fully mixes, be transferred to temporary storage tank II; Temporary storage tank I and the material in temporary storage tank II are transferred to temporary storage tank III, mix;
Second step: high-pressure homogeneous, temperature be 60 DEG C, the mixed liquor in temporary storage tank III carries out homogeneous under being the condition of 20MPa by pressure;
Mixed liquor through homogeneous is sterilization 20 ~ 25 seconds under the condition of 88 ~ 92 DEG C in temperature by the 3rd step: sterilization;
4th step: concentrated, vacuum be ~ 0.03MPa to ~ 0.08MPa, under temperature is the condition of 55 ~ 65 DEG C, the mixed liquor through sterilization being concentrated into Baume degrees is 18 ° of B é;
5th step: spraying dry, by through concentrated mixed liquor pressure be 18MPa material loading, EAT is 175 DEG C, temperature of outgoing air carries out spraying dry under being the condition of 80 DEG C;
6th step: cool, mixed liquor through super-dry is down to room temperature through fluid bed cooling, in material, water content is 2.0 ~ 3.5%, then compound probiotic freeze-dried powder, arachidonic acid Ultramicro-powder, DHA Ultramicro-powder, lactoferrin and nucleotides is added by predetermined ratio, in screw mixer, mixing 20 minutes to mixing, obtaining probio baby milk powder;
7th step: packaging, adopt vacuum nitrogen or carbon dioxide to carry out controlled atmospheric packing, obtain probio baby milk powder product, label is SY1, and testing result is in Table 1-1.
Table 1-1 SY1 testing result
Clinical trial:
The present embodiment 1 (lactobacillus reuteri SY1) gained probio baby milk powder of filling a prescription is adopted to test, experimental condition is: select symptom of diarrhea in certain hospital neonates section public ward, the state of an illness steadily or Recovery Phase of diseases, gestational age >=37 month, FTNB as research object, research object is divided into two groups at random:
Control group: boy 24 example, girl 16 example, feeds common babies ' formula milk powder, must not use the dairy produce containing prebiotics or probio or other food, observes average time 10.1 ± 2.5 days.
Experimental group: boy 23 example, girl 17 example, feeds a kind of lactobacillus reuteri baby formula milk powder of embodiment 1, as test group, observes average time 10.8 ± 2.1 days.
Two groups of research object ages, sex ratio, childbirth options, observation number of days and maternal age equal distributions are balanced, and there was no significant difference, before and after experiment, does not all find other bad reaction.
The different formulations milk powder of experimental group and control group is fed as follows on the impact of infant faeces, gut flora and immunity:
Observe the incidence of disease of the stool frequency of different feeding group baby, proterties, color, weight and infectious diarrhea, and measure the quantity of probio in infant faeces, as analysis and assessment index, result of the test:
1, ight soil situation:
Control group: stool total degree 1022 times, 2.53 times/day per capita, wherein mushy stool 471 times (accounting for 36.06%), yellow soft stool 439 times (accounting for 52.97%), formed stool 40 times (accounting for 3.90%), rare watery stool 72 times (accounting for 7.07%).
Experimental group: stool total degree 1439 times, 3.33 times/day per capita, wherein mushy stool 790 times (accounting for 64.89%), yellow soft stool 626 times (33.48%), formed stool 14 times (accounting for 0.98%), rare watery stool 9 times (accounting for 0.65%).
Refer to following table 1-2.
Table 1-2 experimental group and control group various trait stool proportion table
| Stool | Mushy stool | Yellow soft stool | Formed stool | Rare watery stool |
| Control group | 46.06％ | 42.97％ | 3.90％ | 7.07％ |
| Experimental group | 54.89％ | 43.48％ | 0.98％ | 0.65％ |
As can be seen from table 1-2, edible embodiment 1 is containing after the probio baby milk powder of lactobacillus reuteri, neonatal average every day, times of defecation significantly improved, mushy stool, yellow soft stool ratio significantly increase, rare watery stool and formed stool significantly reduce, for improving intestinal health and unobstructed, promote the successful of diarrhoea rehabilitation.
2, Bacteria Detection in ight soil:
Before and after the experiment of control group, experimental group, fecal microorganism testing result (P < 0.05), in Table 1-3.
As can be seen from table 1-3, compared to control group, the Bifidobacterium in experimental group in ight soil, lactobacillus quantitatively obviously increase, and Bacillus perfringens quantitatively obviously reduces, to improving infant enteric microorganism composition successful.
The situation (unit: CFU/g) of the contained bacterium in experiment front and back in the ight soil of table 1-3 control group and experimental group
Known by above-mentioned test, the probio baby milk powder of edible embodiment 1 can make the enteron aisle of infant and ight soil have to improve significantly, diarrhoea status also has and improves significantly, and the immunity greatly improving infant, the health improving enteron aisle and unobstructed situation, have great practical value.
Embodiment 2:
A kind of probio baby milk powder, raw material comprises following component:
Lactose 29.3 kilograms, vegetable oil 25.8 kilograms, desalted whey powder 20.1 kilograms, skimmed milk power 12.2 kilograms, concentrated whey protein powder 5.5 kilograms, complex prebiotics 2.5 kilograms, mineral substance premix 1.3 kilograms, arachidonic acid Ultramicro-powder 1.5 kilograms, DHA Ultramicro-powder 1.2 kilograms, vitamin premix 0.23 kilogram, compound probiotic freeze-dried powder 0.2 kilogram, lactoferrin 0.05 kilogram, taurine 0.03 kilogram, VBT 0.03 kilogram and 0.02 kilogram, nucleotides.
Wherein: in described mineral matter, comprise following raw material components in mass fraction: potassium chloride 30.5%, natrium citricum 26.6%, tricalcium phosphate 22.4%, magnesium sulfate 13.5%, calcium carbonate 5.5%, ferrous sulfate 0.73%, zinc sulfate 0.65%, copper sulphate 0.0755%, manganese sulfate 0.037%, KI 0.0056% and sodium selenite 0.0019%.
Following raw material components is comprised in mass fraction: L-AA sodium 39.1% in described vitamin premix, Choline Chloride 32.3%, inositol 18.3%, dl-α-D-α-tocopherol acetate 5.1%, niacinamide 2.1%, D-VB5 calcium 1.51%, riboflavin 0.52%, axerophtholum aceticum 0.27%, thiamine hydrochloride 0.45%, puridoxine hydrochloride 0.29%, folic acid 0.023%, phytondione 0.024%, Bio 0.008%, vitamine D3 0.004% and cyanocobalamin 0.001%.
In described compound probiotic freeze-dried powder: the bacterial strain number of described lactobacillus reuteri is DSM17938, and its content is 6 × 10
7cFU/g; The bacterial strain number of described animal bifidobacteria is Bb ~ 12, and its content is 2 × 10
7cFU/g.
In described complex prebiotics, the mass ratio of FOS and galactooligosaccharide is 9:1.
Described vegetable oil comprises sunflower oil, coconut oil and soybean oil.
The preparation method of the present embodiment probio baby milk powder is as follows:
The first step: batching, respectively by lactose, desalted whey powder, skimmed milk power, concentrated whey protein powder, complex prebiotics, mineral substance premix, water miscible vitamin premix, taurine and VBT that predetermined ratio takes, dropping into temperature is fully dissolve mixing in the water of 4 times of weight of 45 DEG C, is transferred to temporary storage tank I; Take vegetable oil by predetermined ratio and fat-soluble vitamin premix fully mixes, be transferred to temporary storage tank II; Temporary storage tank I and the material in temporary storage tank II are transferred to temporary storage tank III, mix;
Second step: high-pressure homogeneous, temperature be 60 DEG C, the mixed liquor in temporary storage tank III carries out homogeneous under being the condition of 20MPa by pressure;
Mixed liquor through homogeneous is sterilization 20 ~ 25 seconds under the condition of 88 ~ 92 DEG C in temperature by the 3rd step: sterilization;
4th step: concentrated, vacuum be ~ 0.03MPa to ~ 0.08MPa, under temperature is the condition of 55 ~ 65 DEG C, the mixed liquor through sterilization being concentrated into Baume degrees is 18 ° of B é;
5th step: spraying dry, by through concentrated mixed liquor pressure be 18MPa material loading, EAT is 175 DEG C, temperature of outgoing air carries out spraying dry under being the condition of 80 DEG C;
6th step: cool, mixed liquor through super-dry is down to room temperature through fluid bed cooling, in material, water content is 2.0 ~ 3.5%, then compound probiotic freeze-dried powder, arachidonic acid Ultramicro-powder, DHA Ultramicro-powder, lactoferrin and nucleotides is added by predetermined ratio, in screw mixer, mixing 20 minutes to mixing, obtaining probio baby milk powder;
7th step: packaging, adopt vacuum nitrogen or carbon dioxide to carry out controlled atmospheric packing, obtain probio baby milk powder product, label is SY2, and testing result is in Table 2-1.
Table 2-1 SY2 testing result
Clinical testing
The present embodiment 2 (lactobacillus reuteri SY2) gained probio baby milk powder of filling a prescription is adopted to test, experimental condition is: select symptom of diarrhea in certain hospital neonates section public ward, the state of an illness steadily or Recovery Phase of diseases, gestational age >=37 month, FTNB as research object, research object is divided into two groups at random:
Control group: boy 18 example, girl 26 example, feeds common babies ' formula milk powder, must not use the dairy produce containing prebiotics or probio or other food, observes average time 10.1 ± 2.1 days.
Experimental group: boy 20 example, girl 25 example, feeds a kind of lactobacillus reuteri baby formula milk powder of embodiment 2, as test group, observes average time 10.3 ± 1.9 days.
Two groups of research object ages, sex ratio, childbirth options, observation number of days and maternal age equal distributions are balanced, and there was no significant difference, before and after experiment, does not all find other bad reaction.
The different formulations milk powder of experimental group and control group is fed as follows on the impact of infant faeces, gut flora and immunity:
Observe the incidence of disease of the stool frequency of different feeding group baby, proterties, color, weight and infectious diarrhea, and measure the quantity of probio in infant faeces, as analysis and assessment index, result of the test:
1, ight soil situation:
Control group: stool total degree 1052 times, 2.49 times/day per capita, wherein mushy stool 484 times (accounting for 46.01%), yellow soft stool 397 times (accounting for 37.74%), formed stool 72 times (accounting for 6.84%), rare watery stool 99 times (accounting for 9.41%).
Experimental group: stool total degree 1541 times, 3.42 times/day per capita, wherein mushy stool 873 times (accounting for 56.65%), yellow soft stool 626 times (42.96%), formed stool 28 times (accounting for 1.82%), rare watery stool 14 times (accounting for 0.91%).
Refer to table 2-2.
Table 2-2 experimental group and control group various trait stool proportion table
| Stool | Mushy stool | Yellow soft stool | Formed stool | Rare watery stool |
| Control group | 46.01％ | 37.74％ | 6.84％ | 9.41％ |
| Experimental group | 56.65％ | 42.96％ | 1.82％ | 0.91％ |
As can be seen from table 2-2, edible SY2 is containing after the probio baby milk powder of lactobacillus reuteri, neonatal average every day, times of defecation significantly improved, mushy stool, yellow soft stool ratio significantly increase, rare watery stool and formed stool significantly reduce, for improving intestinal health and unobstructed, promote the successful of diarrhoea rehabilitation.
2, Bacteria Detection in ight soil:
Before and after the experiment of control group, experimental group, fecal microorganism testing result (P < 0.05), in Table 2-3.
As can be seen from table 2-3, compared to control group, the Bifidobacterium in experimental group in ight soil, lactobacillus quantitatively obviously increase, and Bacillus perfringens quantitatively obviously reduces, to improving infant enteric microorganism composition successful.
The situation (unit: CFU/g) of the contained bacterium in experiment front and back in the ight soil of table 2-3 control group and experimental group
Known by above-mentioned test, the probio baby milk powder of edible embodiment 2 can make the enteron aisle of infant and ight soil have to improve significantly, diarrhoea status also has and improves significantly, and the immunity greatly improving infant, the health improving enteron aisle and unobstructed situation, have great practical value.
Embodiment 3:
A kind of probio baby milk powder, raw material comprises following component:
Lactose 31 kilograms, vegetable oil 24 kilograms, desalted whey powder 20 kilograms, skimmed milk power 9 kilograms, concentrated whey protein powder 7.2 kilograms, complex prebiotics 4.2 kilograms, mineral substance premix 1.74 kilograms, arachidonic acid Ultramicro-powder 1.03 kilograms, DHA Ultramicro-powder 1.03 kilograms, vitamin premix 0.25 kilogram, compound probiotic freeze-dried powder 0.25 kilogram, lactoferrin 0.09 kilogram, VBT 0.028 kilogram, taurine 0.037 kilogram and 0.045 kilogram, nucleotides.
Wherein: in described mineral substance premix, comprise following raw material components in mass fraction: potassium chloride 32.8%, natrium citricum 27.2%, tricalcium phosphate 18.2%, magnesium sulfate 13.39%, calcium carbonate 7.1%, ferrous sulfate 0.64%, zinc sulfate 0.58%, copper sulphate 0.053%, manganese sulfate 0.027%, KI 0.0069% and sodium selenite 0.0031%.
Following raw material components is comprised in mass fraction: L-AA sodium 36.8%, Choline Chloride 32.9%, inositol 17.7%, dl-α-D-α-tocopherol acetate 5.7%, niacinamide 2.5%, D-VB5 calcium 2.60%, riboflavin 0.52%, thiamine hydrochloride 0.41%, axerophtholum aceticum 0.30%, puridoxine hydrochloride 0.45%, folic acid 0.09%, phytondione 0.011%, Bio 0.015%, vitamine D3 0.003% and cyanocobalamin 0.001% in described vitamin premix.
In described compound probiotic freeze-dried powder: the bacterial strain number of described lactobacillus reuteri is DSM17938, and its content is 8 × 10
7cFU/g; The bacterial strain number of described animal bifidobacteria is Bb ~ 12, and its content is 1 × 10
7cFU/g.
The mass ratio of FOS, galactooligosaccharide, polydextrose described in described complex prebiotics is 1:1:8.
Described vegetable oil comprises sunflower oil, coconut oil and soybean oil.
The preparation method of the present embodiment probio baby milk powder is as follows:
The first step: batching, respectively by lactose, desalted whey powder, skimmed milk power, concentrated whey protein powder, complex prebiotics, mineral substance premix, water miscible vitamin premix, taurine and VBT that predetermined ratio takes, dropping into temperature is fully dissolve mixing in the water of 4 times of weight of 45 DEG C, is transferred to temporary storage tank I; Take vegetable oil by predetermined ratio and fat-soluble vitamin premix fully mixes, be transferred to temporary storage tank II; Temporary storage tank I and the material in temporary storage tank II are transferred to temporary storage tank III, mix;
Second step: high-pressure homogeneous, temperature be 62 DEG C, the mixed liquor in temporary storage tank III carries out homogeneous under being the condition of 15MPa by pressure;
Mixed liquor through homogeneous is sterilization 20 ~ 25 seconds under the condition of 88 ~ 92 DEG C in temperature by the 3rd step: sterilization;
4th step: concentrated, vacuum be ~ 0.03MPa to ~ 0.08MPa, under temperature is the condition of 55 ~ 65 DEG C, the mixed liquor through sterilization being concentrated into Baume degrees is 18 ° of B é;
5th step: spraying dry, by through concentrated mixed liquor pressure be 18MPa material loading, EAT is 175 DEG C, temperature of outgoing air carries out spraying dry under being the condition of 80 DEG C;
6th step: cool, mixed liquor through super-dry is down to room temperature through fluid bed cooling, in material, water content is 2.0 ~ 3.5%, then compound probiotic freeze-dried powder, arachidonic acid Ultramicro-powder, DHA Ultramicro-powder, lactoferrin and nucleotides is added by predetermined ratio, in screw mixer, mixing 20 minutes to mixing, obtaining probio baby milk powder;
7th step: packaging, adopt vacuum nitrogen or carbon dioxide to carry out controlled atmospheric packing, obtain probio baby milk powder product, label is SY3, and testing result is in Table 3-1.
Table 3-1 SY3 testing result
Clinical testing
The present embodiment 3 (lactobacillus reuteri SY3) gained probio baby milk powder of filling a prescription is adopted to test, experimental condition is: select symptom of diarrhea in certain hospital neonates section public ward, the state of an illness steadily or Recovery Phase of diseases, gestational age >=37 month, FTNB as research object, research object is divided into two groups at random:
Control group: boy 23 example, girl 24 example, feeds common babies ' formula milk powder, must not use the dairy produce containing prebiotics or probio or other food, observes average time 10.2 ± 1.3 days.
Experimental group: boy 25 example, girl 22 example, feeds a kind of lactobacillus reuteri baby formula milk powder of embodiment 3, as test group, observes average time 10.3 ± 1.5 days.
Two groups of research object ages, sex ratio, childbirth options, observation number of days and maternal age equal distributions are balanced, and there was no significant difference, before and after experiment, does not all find other bad reaction.
The different formulations milk powder of experimental group and control group is fed as follows on the impact of infant faeces, gut flora and immunity:
Observe the incidence of disease of the stool frequency of different feeding group baby, proterties, color, weight and infectious diarrhea, and measure the quantity of probio in infant faeces, as analysis and assessment index, result of the test:
1, ight soil situation:
Control group: stool total degree 1156 times, 2.46 times/day per capita, wherein mushy stool 553 times (accounting for 47.84%), yellow soft stool 478 times (accounting for 41.35%), formed stool 45 times (accounting for 3.89%), rare watery stool 80 times (accounting for 6.82%).
Experimental group: stool total degree 1589 times, 3.38 times/day per capita, wherein mushy stool 926 times (accounting for 58.28%), yellow soft stool 634 times (39.90%), formed stool 17 times (accounting for 1.07%), rare watery stool 12 times (accounting for 0.75%).
Refer to table 3-2.
Table 3-2 experimental group and control group various trait stool proportion table
| Stool | Mushy stool | Yellow soft stool | Formed stool | Rare watery stool |
| Control group | 47.84％ | 41.35％ | 3.89％ | 6.82％ |
| Experimental group | 58.28％ | 39.90％ | 1.07％ | 0.75％ |
As can be seen from table 3-2, edible SY3 is containing after the probio baby milk powder of lactobacillus reuteri, neonatal average every day, times of defecation significantly improved, mushy stool, yellow soft stool ratio significantly increase, rare watery stool and formed stool significantly reduce, for improving intestinal health and unobstructed, promote the successful of diarrhoea rehabilitation.
2, Bacteria Detection in ight soil
Before and after the experiment of control group, experimental group, fecal microorganism testing result (P < 0.05), in Table 3-3.
As can be seen from table 3-3, compared to control group, the Bifidobacterium in experimental group in ight soil, lactobacillus quantitatively obviously increase, and Bacillus perfringens quantitatively obviously reduces, to improving infant enteric microorganism composition successful.
The situation (unit: CFU/g) of the contained bacterium in experiment front and back in the ight soil of table 3-3 control group and experimental group
Known by above-mentioned test, the probio baby milk powder of edible embodiment 3 can make the enteron aisle of infant and ight soil have to improve significantly, diarrhoea status also has and improves significantly, and the immunity greatly improving infant, the health improving enteron aisle and unobstructed situation, have great practical value.
The foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, for a person skilled in the art, the present invention can have various modifications and variations.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. a probio baby milk powder, it is characterized in that: with weight parts, raw material comprises following component: lactose 10 ~ 40 parts, vegetable oil 21 ~ 29 parts, desalted whey powder 10 ~ 40 parts, skimmed milk power 5 ~ 25 parts, concentrated whey protein powder 0 ~ 12 part, complex prebiotics 1 ~ 4.5 part, mineral substance premix 0.5 ~ 2.5 part, arachidonic acid Ultramicro-powder 0.3 ~ 1.8 part, DHA Ultramicro-powder 0.2 ~ 1.8 part, vitamin premix 0.1 ~ 0.5 part, compound probiotic freeze-dried powder 0.04 ~ 0.4 part, lactoferrin 0 ~ 0.10 part, VBT 0.01 ~ 0.03 part, taurine 0.02 ~ 0.05 part and 0.015 ~ 0.055 part, nucleotides,
In described arachidonic acid Ultramicro-powder, the mass percentage of ARA is more than or equal to 10%;
In described DHA Ultramicro-powder, the mass percentage of DHA is more than or equal to 7%;
Described compound probiotic freeze-dried powder comprises lactobacillus reuteri and animal bifidobacteria, and the bacterial strain number of described lactobacillus reuteri is DSM17938, and its content is 1 × 10
7~ 1 × 10
9cFU/g; The bacterial strain number of described animal bifidobacteria is Bb ~ 12, and its content is 0 ~ 1 × 10
8cFU/g.
2. probio baby milk powder according to claim 1, is characterized in that:
Described vegetable oil comprises at least three kinds in sunflower oil, coconut oil, soybean oil, Canola Oil, palm oil and palm-kernel oil;
Following raw material components is comprised in mass fraction: potassium chloride 28 ~ 38%, natrium citricum 20 ~ 28%, tricalcium phosphate 15 ~ 25%, magnesium sulfate 8 ~ 15%, calcium carbonate 3 ~ 8%, ferrous sulfate 0.6 ~ 1.5%, zinc sulfate 0.5 ~ 1.2%, copper sulphate 0.05 ~ 0.15%, manganese sulfate 0.01 ~ 0.05%, KI 0.005 ~ 0.015% and sodium selenite 0.0015 ~ 0.0035% in described mineral substance premix;
Following raw material components is comprised in mass fraction: L-AA sodium 38 ~ 48% in described vitamin premix, Choline Chloride 23 ~ 33%, inositol 12 ~ 22%, dl-α-D-α-tocopherol acetate 5 ~ 10%, niacinamide 1.0 ~ 3.0%, D-VB5 calcium 1.0 ~ 3.0%, riboflavin 0.3 ~ 1.0%, thiamine hydrochloride 0.2 ~ 0.8%, axerophtholum aceticum 0.1 ~ 0.6%, puridoxine hydrochloride 0.1 ~ 0.5%, folic acid 0.01 ~ 0.10%, phytondione 0.01 ~ 0.05%, Bio 0.008 ~ 0.03%, vitamine D3 0.002 ~ 0.007% and cyanocobalamin 0.001 ~ 0.003%,
Described complex prebiotics comprises at least one in FOS, galactooligosaccharide, polydextrose and polyfructosan.
3. probio baby milk powder according to claim 2, is characterized in that: the content proportioning of described lactobacillus reuteri and described animal bifidobacteria is 1:1.
4. probio baby milk powder according to claim 3, is characterized in that: with weight parts, and raw material comprises following component:
Lactose 32.6 parts, vegetable oil 25.8 parts, desalted whey powder 16.8 parts, skimmed milk power 10.9 parts, concentrated whey protein powder 6.6 parts, complex prebiotics 3.5 parts, mineral substance premix 1.5 parts, arachidonic acid Ultramicro-powder 1.0 parts, DHA Ultramicro-powder 0.81 part, vitamin premix 0.24 part, compound probiotic freeze-dried powder 0.08 part, lactoferrin 0.08 part, VBT 0.02 part, taurine 0.04 part and 0.03 part, nucleotides;
Following raw material components is comprised in mass fraction: potassium chloride 35.5%, natrium citricum 24.4%, tricalcium phosphate 21.1%, magnesium sulfate 12.5%, calcium carbonate 4.8%, ferrous sulfate 0.88%, zinc sulfate 0.72%, copper sulphate 0.065%, manganese sulfate 0.025%, KI 0.0076% and sodium selenite 0.0024% in described mineral substance premix;
Following raw material components is comprised in mass fraction: L-AA sodium 43.1%, Choline Chloride 28.8%, inositol 16.7%, dl-α-D-α-tocopherol acetate 7.1%, niacinamide 1.8%, D-VB5 calcium 1.08%, riboflavin 0.41%, thiamine hydrochloride 0.33%, axerophtholum aceticum 0.30%, puridoxine hydrochloride 0.31%, folic acid 0.03%, phytondione 0.025%, Bio 0.010%, vitamine D3 0.004% and cyanocobalamin 0.001% in described vitamin premix;
The mass ratio of FOS and described galactooligosaccharide described in described complex prebiotics is 2:8.
5. probio baby milk powder according to claim 2, is characterized in that: the content proportioning of described lactobacillus reuteri and described animal bifidobacteria is 3:1.
6. probio baby milk powder according to claim 5, is characterized in that: with weight parts, and raw material comprises following component:
Lactose 29.3 parts, vegetable oil 25.8 parts, desalted whey powder 20.1 parts, skimmed milk power 12.2 parts, concentrated whey protein powder 5.5 parts, complex prebiotics 2.5 parts, mineral substance premix 1.3 parts, arachidonic acid Ultramicro-powder 1.5 parts, DHA Ultramicro-powder 1.2 parts, vitamin premix 0.23 part, compound probiotic freeze-dried powder 0.2 part, lactoferrin 0.05 part, VBT 0.03 part, taurine 0.03 part and 0.02 part, nucleotides;
Following raw material components is comprised in mass fraction: potassium chloride 30.5%, natrium citricum 26.6%, tricalcium phosphate 22.4%, magnesium sulfate 13.5%, calcium carbonate 5.5%, ferrous sulfate 0.73%, zinc sulfate 0.65%, copper sulphate 0.0755%, manganese sulfate 0.037%, KI 0.0056% and sodium selenite 0.0019% in described mineral matter;
Following raw material components is comprised in mass fraction: L-AA sodium 39.1% in described vitamin premix, Choline Chloride 32.3%, inositol 18.3%, dl-α-D-α-tocopherol acetate 5.1%, niacinamide 2.1%, D-VB5 calcium 1.51%, riboflavin 0.52%, thiamine hydrochloride 0.45%, axerophtholum aceticum 0.27%, puridoxine hydrochloride 0.29%, folic acid 0.023%, phytondione 0.024%, Bio 0.008%, vitamine D3 0.004% and cyanocobalamin 0.001%,
In described complex prebiotics, the mass ratio of FOS and galactooligosaccharide is 9:1.
7. probio baby milk powder according to claim 2, is characterized in that: the content proportioning of described lactobacillus reuteri and described animal bifidobacteria is 8:1.
8. probio baby milk powder according to claim 7, is characterized in that: with weight parts, and raw material comprises following component:
Lactose 31 parts, vegetable oil 24 parts, desalted whey powder 20 parts, skimmed milk power 9 parts, concentrated whey protein powder 7.2 parts, complex prebiotics 4.2 parts, mineral substance premix 1.74 parts, arachidonic acid Ultramicro-powder 1.03 parts, DHA Ultramicro-powder 1.03 parts, vitamin premix 0.25 part, compound probiotic freeze-dried powder 0.25 part, lactoferrin 0.09 part, VBT 0.028 part, taurine 0.037 part and 0.045 part, nucleotides;
Following raw material components is comprised in mass fraction: potassium chloride 32.8%, natrium citricum 27.2%, tricalcium phosphate 18.2%, magnesium sulfate 13.39%, calcium carbonate 7.1%, ferrous sulfate 0.64%, zinc sulfate 0.58%, copper sulphate 0.053%, manganese sulfate 0.027%, KI 0.0069% and sodium selenite 0.0031% in described mineral substance premix;
Following raw material components is comprised in mass fraction: L-AA sodium 36.8%, Choline Chloride 32.9%, inositol 17.7%, dl-α-D-α-tocopherol acetate 5.7%, niacinamide 2.5%, D-VB5 calcium 2.60%, riboflavin 0.52%, thiamine hydrochloride 0.41%, axerophtholum aceticum 0.30%, puridoxine hydrochloride 0.45%, folic acid 0.09%, phytondione 0.011%, Bio 0.015%, vitamine D3 0.003% and cyanocobalamin 0.001% in described vitamin premix;
The mass ratio of FOS, galactooligosaccharide, polydextrose described in described complex prebiotics is 1:1:8.
9. the probio baby milk powder according to claim 4 or 6 or 8, is characterized in that: described vegetable oil comprises sunflower oil, coconut oil and soybean oil.
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