CN106720347A - A kind of neonate's prescription emulsifiable powder containing probiotics and preparation method thereof - Google Patents
A kind of neonate's prescription emulsifiable powder containing probiotics and preparation method thereof Download PDFInfo
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- CN106720347A CN106720347A CN201611030183.7A CN201611030183A CN106720347A CN 106720347 A CN106720347 A CN 106720347A CN 201611030183 A CN201611030183 A CN 201611030183A CN 106720347 A CN106720347 A CN 106720347A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
A kind of neonate's prescription emulsifiable powder containing probiotics disclosed by the invention, raw material include raw milk, lactose, mixed vegetable oil, active probiotic freeze-dried powder, the method for preparing the milk powder is also disclosed, is comprised the following steps, raw material is mixed to obtain feed liquid A by (1)；(2) sterilized by feed liquid A homogeneous, concentration, spray drying obtains material B；(3) material B is well mixed with bioactivator, unrighted acid and active probiotic in dry-mixed workshop and obtains final product milk powder.It is an advantage of the current invention that the prescription emulsifiable powder of neonate containing probiotics of the invention is a kind of neonate's formula powder containing probiotics developed for (0 28 days) for neonate according to the nutritional ingredient and active material feature of breast milk (colostrum and transitional milk).The preparation method of probiotics neonate prescription emulsifiable powder of the present invention, can guarantee that the product of milk powder is homogeneous simultaneously, and shelf stable, probiotics survives for a long time in milk powder.
Description
Technical field
The invention belongs to neonate's diatery supplement technical field, specially a kind of neonate's prescription emulsifiable powder and its system containing probiotics
Preparation Method.
Background technology
Breast milk is most healthy baby, the most comprehensive food of nutrition.After neonate's birth, not only can obtain enough from breast milk
Nutriment, and various bioactie agents can also be obtained from breast milk.General breast-fed babies' anti-sense of its intestines and stomach
The ability of dye is strong, and the probability that baby suffers from anaphylactia is low, therefore breast milk is the optimal food of infant.Yet with various
Reason, breast-feeding can not meet all babies, therefore composition is close, and function is to carry out close to the formula milk of breast milk
The first-selection of breast feeding babies.
The breast milkization of the formula powder of early stage is mainly constituted through by adjusting the albumen of formula powder, and grease is constituted and adds prebiotic
Breast milk is simulated by unit.The improvement of these formulas makes formula powder fed infant in growth, anthropometic, intestinal health, tolerance
The step of previous step one it is close in breast-fed babies.Such as, the addition of prebiotics improves infant powder feeding infant stool
It is bad, enteric microorganism constitute it is unreasonable the problems such as；The addition of Structure grease improves absorption of the infant for fat and calcium
Digestive problems, make formula powder fed infant not only increase the absorption of aliphatic acid and calcium, and mitigate or eliminate and do not change
Enter the calcium soap problem that reinforced structure grease causes.
But, the improvement of breast milk nutrient component is only carried out, it is also far from enough.Current research is it has been proved that breast milk
Inside also contain multiple beneficial microorganism.These microorganisms can pass to baby by wet nurse, and be colonized in baby intestinal, with
Contribute to the formation of baby's early stage healthy enteron aisle.Therefore, simulation Infant Formula Enterprises are more nearly with breast milk can not ignore mother
Influence of the beneficial bacterium for infantile health in newborn.In addition, nutriment is with lactating time dynamic change in breast milk.One
As colostrum contain more high immunoglobulinlg, lactoferrin and sialic acid etc. than ripe breast；The presence of these materials has beneficial to protection
Neonate escapes injury when facing new environment.These problems remind us, when Infant Formula Enterprises are developed, are considered as infant
Residing age level, gives neonate and more pays close attention to.
The content of the invention
To solve general Infant Formula Enterprises active material (immunoglobulin, lactoferrin, sialic acid etc.) content with mother
Newborn (colostrum and transitional milk) difference is big, and Structure grease content is low, and the problems such as probiotics milk powder stability difference, the present invention provides a kind of
It is more suitable for neonatal milk powder containing probiotic formulation and preparation method thereof.
It is an object of the invention to be approached with colostrum and transitional milk for neonate provides a kind of component, the new life containing probiotics
Youngster's formula powder, the formula powder contains the infant growths such as protein, lipid, carbohydrate, vitamin and mineral matter most
Basic material, while also containing the lactoferrin that first milk content is higher, immunoglobulin, sialic acid and probiotics etc..
To achieve these goals, technical scheme disclosed by the invention is：It is disclosed by the invention a kind of containing the new of probiotics
Raw youngster's prescription emulsifiable powder, raw material include raw milk 14.75~29.97%, lactose 18.36~41.28%, mixed vegetable oil
16.40~26.55%, active probiotic freeze-dried powder 0.06~0.25% is stated corresponding to be converted into when raw milk calculates percentage
The amount of whole-fat milk powder and/or skimmed milk powder；Described percentage accounts for the mass percent containing milk powder raw material for each component.
Further, raw material also include desalted whey powder 0.00~30.89%, WPC 4.48~
12.29%, prebiotics 2.09~4.43%, bioactivator 0.41~0.80%, B B-complex 0.3~0.8% is combined
Mineral matter 0.15~0.30%, unrighted acid 1.19~3.99%, additives 0.07~0.37%, described percentage is
Each component accounts for the mass percent of milk powder raw material.
Further, raw material include sodium chloride 0.00~0.55%, potassium chloride 0.00~0.35%, calcium carbonate 0.00~
0.39%, described percentage accounts for the mass percent of milk powder raw material for each component.
In the present invention, the raw milk is preferably raw milk and is constituted with skimmed milk.Wherein, described whole-fat milk powder
Can be substituted with raw milk commonly used in the art, described skimmed milk powder can use degreasing ox commonly used in the art
Breast is substituted, and the conversion ratio of milk powder and cow's milk is converted according to this area routine ratio, generally：Whole-fat milk powder quality=full-cream ox
Breast matter amount * 0.117/0.97, skimmed milk powder quality=skimmed milk quality * 0.081/0.96.
In the present invention, described lactose is this area routine lactose.
In the present invention, described desalted whey powder is this area conventional desalination whey powder.Preferably D70, D80, D90；
In the present invention, described concentrated whey protein powder is this area Conventional concentration PURE WHEY.Preferred protein contains
Measure the concentrated whey protein powder for 80%~82%.More preferably, WPC protein content >=80%, α-breast
Albumin >=25%, the percentage is mass percent.
In the present invention, described mixed vegetable oil is the conventional mixed vegetable oil in this area.Described mixed vegetable oil compared with
Contain the mixed vegetable oil of the compoundings such as soybean oil, sunflower oil, palm-kernel oil, linseed oil goodly；Preferably described grease
Aliphatic acid is constituted：Octanoic acid≤1.2%；Certain herbaceous plants with big flowers acid 0.1~1%；Laurate 2~6%；Myristic acid 0.8~4%；Palmitic acid 17.5
~22.5%；Palmitoleic acid≤2%；Stearic acid
3~5%；Oleic acid 35~42.5%；Linoleic acid 25~31%；Alpha-linolenic acid 2.5~4.1%；Total trans-fatty acid
≤ 1.0%；Tripalmitin≤10%；Ester >=19% of bis- oleic acid 2- palmitic acids of 1,3- three；Sn-2 palmitic acids >=
42%.The percentage accounts for the score ratio of TFA for aliphatic acid.
In the present invention, the prebiotics is the conventional prebiotics in this area.It is preferred that described prebiotics is selected from oligomeric different
One or more in maltose, FOS, galactooligosaccharide, polyfructosan, lactulose and xylo-oligosaccharide, more preferably for low
Poly- galactolipin and/or polyfructosan.
In the present invention, described bioactivator is this area standard biologic active material.Preferably selected from newborn iron egg
In vain, one or more of immunoglobulin and sialic acid, more preferably lactoferrin and/or immunoglobulin.
In the present invention, described B B-complex is the conventional B B-complex in this area.Described B B-complex, be
The uniform mixed semi-finished product compounding raw material of multivitamin monomer.The composition and consumption of described B B-complex only need to meet
Various vitamins and mineral matter reach the content of each vitamin in neonate's formula food in final products.Wherein, preferably
Ground compounds vitamin：Every 100 grams of B B-complexes contain vitamin A, 148~222mgRE；Vitamin D, 2.8~4.3mg；Dimension
Raw element E, 3200~4900mg α-TE；Vitamin K1, 16.3~23.5mg；Vitamin B1, 232~348mg；Vitamin B2, 115
~171mg；Vitamin B6, 114~171mg；Vitamin B12, 600~900 μ g；Nicotinic acid, 1540~2310mg；Folic acid, 25~
38mg；Pantothenic acid, 880~1300mg；Vitamin C, 52800mg~72900mg；Biotin, 7070 μ g~10600 μ g.
In the present invention, described mineral matter be it is commonly used in the art can provide potassium, copper, iron, zinc, manganese, calcium, iodine,
The mineral matter of chlorine and selenium element.Preferably copper gluconate, ferrous gluconate, zinc sulfate, magnesium sulfate, manganese sulfate, iodate
Potassium and sodium selenite etc. compounding form, for infant formula type products in, primarily serve the effect of nutrition fortifier.Its
In, preferably compounding vitamin is：Every 100 grams of mineral matter cuprics, 224~336mg；Magnesium, 3640~5460mg；Iron, 2800
~4200mg；Zinc, 2800~4200mg；Manganese, 27.5~45.0mg；Iodine, 55.5~83.0mg；Selenium, 12~18mg.
In the present invention, described unrighted acid is this area routine unrighted acid.Preferably it is selected from peanut four
Olefin(e) acid, DHA, more preferably one or more of linoleic acid plus linolenic acid, arachidonic acid and/or 22
Carbon acid.Powdered oil of the described unrighted acid preferably through embedding.
In the present invention, described optional material is that commonly used in the art can provide taurine, nucleotides and courage
The optional material of alkali.It is preferred that described optional material is selected from one or more in taurine, nucleotides and choline,
More preferably it is taurine, nucleotides and/or choline.
In the present invention, the active probiotic is this area routine probiotics, and the probiotics refers to can be with viable bacteria state
Intestines and stomach are reached, is made up of regulating intestinal canal flora, play human body or animal single or specific micro- life of effect good for health
The mixed type probiotics of thing.The probiotics is preferably selected from bifidobacterium bifidum (Bifidobacterium bifidum), baby
Youngster Bifidobacterium (Bifidobacterium infantis), bifidobacterium adolescentis (Bifidobacterium
Adolescentis), bifidobacterium breve (Bifidobacterium breve), bifidobacterium lactis (Bifidobacterium
Lactis), bifidobacterium longum (Bifidobacterium longum), animal bifidobacteria (Bifidobacterium
Animalis), lactobacillus acidophilus (Lactobacillus acidophilus) and Lactobacillus rhamnosus (Lactobacillus
Rhamnosus one or more in), it is therefore preferable to animal bifidobacteria (Bifidobacterium animalis), wherein
The preparation method of the probiotics is this area customary preparation methods, or can be by commercially available acquisition.The probiotics adds
Dosage is preferably 1 × 107Cfu/g~1 × 108Cfu/g, is more preferably 3 × 107Cfu/g~6 × 107Cfu/g, it is therefore preferable to
3×107cfu/g。
In the present invention, the water content of the described prescription emulsifiable powder of neonate containing probiotics is 2.5~3.5%.Preferably
3%.Described percentage accounts for the mass percent of the prescription emulsifiable powder raw material of neonate containing probiotics for each component.
In the present invention, described water activity is this area common aqueous activity.Water activity awPreferably 0.15~
0.25, it is therefore preferable to 0.2.
Present invention also offers a kind of preparation method of the above-mentioned prescription emulsifiable powder of neonate containing probiotics, described preparation method
Carry out in the following manner：
(1) it is raw milk is sterilized, obtain the raw milk after sterilization；With the raw milk solubilized lactose after sterilization, desalted whey
Powder, WPC, mixed vegetable oil, prebiotics；B B-complex, composite mineral matter, after material may be selected are pre-dissolved with water
It is well mixed with raw milk, is hydrated, obtains feed liquid A.
(2) sterilized by feed liquid A homogeneous, concentration, spray drying obtains material B；
(3) material B is well mixed i.e. with bioactivator, unrighted acid and active probiotic in dry-mixed workshop
Obtain neonate's prescription emulsifiable powder.
In step (1), described is mixed into this area routine operation, is carried out typically in batch mixer.
In step (1), in the raw milk solubilized lactose with after sterilization, desalted whey powder, WPC, mixing
Vegetable oil, prebiotics, preferably mix before lactose, desalted whey powder, WPC and prebiotics premix after again with original
Material breast is well mixed, then be heated to 40~50 DEG C of mixed vegetable oils and be well mixed.
In step (1), the water is pre-dissolved B B-complex, and composite mineral matter mixes after material may be selected with raw milk
Uniformly, as long as the consumption of preferably described water can be such that the B B-complex, composite mineral matter, optional material divides in water
Dissipate and be well mixed, be more preferably 8~10 times of the B B-complex and composite mineral matter gross mass.
In step (2), described homogeneous is this area routine operation, and homogenization pressure is preferably 15~25MPa, and temperature is
55~65 DEG C.Described sterilization is this area routine operation, it is preferred that the sterilized condition is 85~95 DEG C of temperature, time
15~25 seconds.Described concentration is this area routine operation, preferably quadruple effect falling film concentration technique, and the concentrated milk's of gained consolidates
Shape thing concentration is 42~48% (percentage is mass percent).The spray drying is the routine operation of this area, institute
The EAT for stating spray drying is preferably 165~190 DEG C, and temperature of outgoing air is preferably 80~95 DEG C.The spray drying is preferable
Ground also includes fluidized bed drying, dries out 30~40 DEG C of powder temperature, and moisture is preferably controlled to 2.5~3.5%, the percentage
It is mass percentage content.
In step (3), the method for the mixing is this area routine operation.The method of the mixing be preferably two-stage or
Three-level dilution method, i.e., press 1 with material B respectively by bioactivator, unrighted acid and active probiotic first:(8~
12) premix, the ratio is mass ratio, then carries out two-stage again or three-level is dry-mixed.Wherein described dry-mixed environment temperature is preferable
Ground is 20~30 DEG C, is more preferably 20~25 DEG C, it is therefore preferable to 25 DEG C；Relative humidity is preferably 35%~50%, more preferably
It is 40%~45%, it is therefore preferable to 40%.The percentage is pressure percentage.It is described it is dry-mixed before, the bioactivator,
Unrighted acid and active probiotic are put down from after raw material storage taking-up between should placing the buffering consistent with dry-mixed workshop condition temperature
Weighing apparatus temperature is identical with dry-mixed workshop.
The preparation method of neonate's formula milk of the present invention, preferably also includes packaging step, the packaging step
It is rapid preferably to be packed using composite plastic container or iron flask.Preferably also include taking out packing container very in the packaging step
Sky is filled with inert gas, and the inert gas is this area conventional inert gas, preferably nitrogen and/or carbon dioxide.
On the basis of common sense in the field is met, above-mentioned each optimum condition can be combined, and obtain final product each preferable reality of the present invention
Example.
Agents useful for same of the present invention and raw material are commercially available.
Positive effect of the invention is：
The prescription emulsifiable powder of neonate containing probiotics of the invention is the nutritional ingredient and work according to breast milk (colostrum and transitional milk)
Property material feature be a kind of neonate's formula powder containing probiotics that neonate develops for (0-28 days).The formula powder contains neonate
The most basic nutriments such as protein, lipid, carbohydrate, vitamin and mineral matter needed for growing.Originally simultaneously
The preparation method of the described probiotics neonate's prescription emulsifiable powder of invention, can guarantee that the product of milk powder is homogeneous, and shelf stable is prebiotic
Bacterium survives for a long time in milk powder.
Specific embodiment
The present invention is described in further detail below by specific embodiment.
Embodiment one：A kind of neonate's prescription emulsifiable powder containing probiotics that the present invention is provided, the milk powder raw material include original
Material breast 29.97%, lactose 18.36%, mixed vegetable oil 16.40%, desalted whey powder 24.35%, active probiotic freeze-dried powder
0.06%, WPC 5.96%, prebiotics 2.48%, bioactivator 0.41%, B B-complex 0.3% is multiple
Mineral matter 0.15% is closed, unrighted acid 1.19%, additives 0.37%, balance of water, the raw milk calculates percentage
When be the amount for being converted into corresponding whole-fat milk powder and/or skimmed milk powder；Described percentage accounts for the matter containing milk powder raw material for each component
Amount percentage.
The active probiotic freeze-dried powder is the freeze-dried powder of animal bifidobacteria Bb-12；；
The desalted whey powder is D70；Described WPC is WPC75；Described prebiotics is oligomeric different wheat
Bud sugar, FOS, galactooligosaccharide, polyfructosan, lactulose, xylo-oligosaccharide mix in any proportion；
Bioactivator is lactoferrin, immunoglobulin, sialic acid mix in any proportion；
The composite mineral matter, every 100 grams of mineral matter cupric 224mg；Magnesium 3640mg；Iron 2800mg；Zinc 2800mg；
Manganese 27.5mg；Iodine 55.5mg；Selenium 12mg；
The unsaturation is aliphatic acid, and any ratio is pressed from arachidonic acid, DHA, linoleic acid, leukotrienes
Example mixing；
The additives are that taurine, nucleotides and choline mix according to arbitrary proportion.
Further, the water activity of milk powder is 0.25.
The method for preparing said milk powder, comprises the following steps, (1) is sterilized by raw milk, obtains the raw milk after sterilization；With
Raw milk solubilized lactose after sterilization, WPC, mixed vegetable oil, prebiotics；B B-complex is pre-dissolved with water, is combined
Mineral matter, is well mixed after additives with raw milk, hydration, obtains feed liquid A；
(2) sterilized by feed liquid A homogeneous, concentration, spray drying obtains material B；
(3) material B is well mixed i.e. with bioactivator, unrighted acid and active probiotic in dry-mixed workshop
Obtain milk powder.
In step (1), described water is deionized water；
It is usually pasteurize that described raw milk is sterilized；
Described being mixed into typically is carried out in batch mixer；
It is well mixed with raw milk again after first being premixed before the mixing of the lactose, WPC and prebiotics；
40~50 DEG C are first heated to before the mixed vegetable oil mixing；
The water is pre-dissolved B B-complex, composite mineral matter and additives, if the consumption of the water can make it is described multiple
Vitamin, composite mineral matter, optional material is closed to disperse in water and well mixed.
In step (2), described homogenization pressure is 15~25MPa, and the homogenizing temperature is 55~65 DEG C.
Described sterilized temperature is 85~95 DEG C, and the sterilizing time is 15~25 seconds；
Thickening temperature described in described concentration is 40~50 DEG C, and the terminal of the concentration is to be concentrated into solid content
42~48%, the percentage is mass percent；
The EAT of the spray drying is 165~190 DEG C, and the temperature of outgoing air of the spray drying is 80~95 DEG C,
The spray drying also includes fluidized bed drying, and the fluidized bed drying goes out powder temperature for 30~40 DEG C.
In step (3), the method for the mixing is two-stage or three-level dilution method, and the mixing is first by biological active matter
Matter, unrighted acid, active probiotic press 1 with material B respectively:8~12 premixs, the ratio is mass ratio, is then entered again
Row two-stage or three-level are dry-mixed.
The dry-mixed environment temperature is 20~30 DEG C, and the dry-mixed relative humidity is 35%~50%, the percentage
Than being pressure percentage.
Answer first equilibrium temperature consistent with dry-mixed workshop condition temperature before the dry-mixed raw material is dry-mixed.
The theoretical addition of active probiotic animal bifidobacteria Bb-2 is 1.5 × 10 in gained formula powder7cfu/g。
Uniformity verification method of the probiotics in milk powder is as follows：
(1) milk powder produced by above-described embodiment, takes 3, the sample of packaging front end, 3, middle-end sample, end sample respectively
Product 3 carry out cloud test, verify the feasibility of dry mixing process.
(2) viable count detection method：Weigh 25g powdered milk samples shaken well in 225mL physiological saline.1mL is drawn to add
Enter to 9mL centrifuge tubes that (concentration is 10-2) 10 times of gradient dilutions are carried out step by step, the solution 0.2mL for choosing appropriate dilution is carried out
Pour into experiment.MRS agar mediums use first 121 DEG C, 15min sterilizings.After pour plate solidification, 37 DEG C of Anaerobic culturels are placed on
48h is cultivated in case.Culture dish of the clump count between 30~300 is chosen to be counted.Uniformity knot of the probiotics in milk powder
Fruit is shown in Table 1
Table 1
From the data of table 1, using probiotics as uniform distribution index, dry-mixed technique can meet in embodiment 1
The uniform distribution of dry-mixed raw material.
Embodiment two：A kind of neonate's prescription emulsifiable powder containing probiotics that the present invention is provided, the milk powder raw material include original
Material breast 15.03%, lactose 18.91%, desalted whey powder 30.89%, mixed vegetable oil 21.92%, active probiotic freeze-dried powder
0.08%, WPC 4.48%, prebiotics 2.09%, bioactivator 0.62%, B B-complex 0.8% is multiple
Close mineral matter 0.25%, unrighted acid 3.98%, additives 0.07%, sodium chloride 0.55%, potassium chloride 0.25%, carbonic acid
Calcium 0.30%, balance of water is to be converted into corresponding whole-fat milk powder and/or skimmed milk powder during the raw milk calculating percentage
Amount；Described each percentage accounts for the mass percent containing milk powder raw material for each component.
The active probiotic freeze-dried powder is the freeze-dried powder of animal bifidobacteria Bb-2 and Lactobacillus rhamnosus HN001；Institute
Desalted whey powder is stated for D80；Described WPC is WPC80；Described prebiotics is oligoisomaltose, oligomeric fruit
Sugar, galactooligosaccharide, polyfructosan, lactulose, xylo-oligosaccharide mix in any proportion；
Bioactivator is lactoferrin, immunoglobulin, sialic acid mix in any proportion；
The composite mineral matter, every 100 grams of mineral matter cupric 336mg；Magnesium 5460mg；Iron 4200mg；Zinc 4200mg；
Manganese 45mg；Iodine 83mg；Selenium 18mg；
The unsaturation is aliphatic acid, and any ratio is pressed from arachidonic acid, DHA, linoleic acid, leukotrienes
Example mixing；
The additives are that taurine, nucleotides and choline mix according to arbitrary proportion.
Further, the water activity of milk powder is 0.15.
The method for preparing said milk powder, comprises the following steps, (1) is sterilized by raw milk, obtains the raw milk after sterilization；With
Raw milk solubilized lactose after sterilization, desalted whey powder, WPC, mixed vegetable oil, prebiotics；It is pre-dissolved with water compound
Vitamin, composite mineral matter is well mixed after additives with raw milk, hydration, obtains feed liquid A；
(2) sterilized by feed liquid A homogeneous, concentration, spray drying obtains material B；
(3) material B is well mixed i.e. with bioactivator, unrighted acid and active probiotic in dry-mixed workshop
Obtain milk powder.
In step (1), described water is deionized water；
It is usually pasteurize that described raw milk is sterilized；
Described being mixed into typically is carried out in batch mixer；
Mix with raw milk again after first being premixed before the mixing of the lactose, desalted whey powder, WPC and prebiotics
Uniformly；
40~50 DEG C are first heated to before the mixed vegetable oil mixing；
The water is pre-dissolved B B-complex, composite mineral matter and additives, if the consumption of the water can make it is described multiple
Vitamin, composite mineral matter, optional material is closed to disperse in water and well mixed.
In step (2), described homogenization pressure is 15~25MPa, and the homogenizing temperature is 55~65 DEG C.
Described sterilized temperature is 85~95 DEG C, and the sterilizing time is 15~25 seconds；
Thickening temperature described in described concentration is 40-50 DEG C, and the terminal of the concentration is to be concentrated into solid content
42~48%, the percentage is mass percent；
The EAT of the spray drying is 165~190 DEG C, and the temperature of outgoing air of the spray drying is 80~95 DEG C,
The spray drying also includes fluidized bed drying, and the fluidized bed drying goes out powder temperature for 30~40 DEG C.
In step (3), the method for the mixing is two-stage or three-level dilution method, and the mixing is first by biological active matter
Matter, unrighted acid, active probiotic press 1 with material B respectively:8~12 premixs, the ratio is mass ratio, is then entered again
Row two-stage or three-level are dry-mixed.
The dry-mixed environment temperature is 20~30 DEG C, and the dry-mixed relative humidity is 35%~50%, the percentage
Than being pressure percentage.
Answer first equilibrium temperature consistent with dry-mixed workshop condition temperature before the dry-mixed raw material is dry-mixed.
The theoretical addition of animal bifidobacteria Bb-2 is 3 × 10 in the gained formula powder of embodiment 27Cfu/g, rhamnose breast
The theoretical addition of bacillus HN001 is 3 × 107cfu/g。
The stability verification method of probiotics is as follows under different in moisture activity：
(1) according to process requirements, drying process is controlled to obtain different moisture content and moisture when being spray-dried constantly
The material B of activity, it is then dry-mixed with active probiotic bacterium powder again.The water activity of milk powder is controlled as 0.157,0.196 He
0.243。
(2) prescription emulsifiable powder of different in moisture activity is placed on 37 DEG C of temperature, the constant temperature and humidity culture of relative humidity 75%
In case, in the 0th, 2,4,6,8,10,12 weeks sampling detection viable counts, the stability of probiotics is verified.
(3) viable count detection method：Taken out from insulating box and treat that test sample is positioned over 1~2 hour at room temperature, balance its temperature
It is consistent with room temperature.Weigh 25g samples shaken well in 225mL physiological saline.Absorption 1mL is added to 9mL centrifuge tubes, and (concentration is i.e.
It is 10-2) 10 times of gradient dilutions are carried out step by step, the solution 0.2mL for choosing appropriate dilution carries out pouring into experiment.MRS agar cultures
Base uses first 121 DEG C, 15min sterilizings.When culture medium is cooled to 50 DEG C or so, addition 1.5mg in the MRS culture mediums of 100mL
Mupirocin lithium salts is used for the detection of Bifidobacterium, and addition 0.25mg vancomycins are used for rhamnose in the MRS culture mediums of 100mL
The detection of lactobacillus.After pour plate solidification, it is placed in 37 DEG C of anaerobic culture boxes and cultivates 48h.Clump count is chosen 30~300
Between culture dish counted.The stability result of probiotics is shown in Table 2 under different in moisture activity
Table 2
From the data of table 2, mixing probiotics is under different water activities, and stability is different, but all without
The decline of the order of magnitude.Wherein water activity is best in 0.157 and 0.196 stability inferior, it is therefore proposed that the water containing probiotics milk powder
Activity is divided to control between 0.15~0.2.
Embodiment three：A kind of neonate's prescription emulsifiable powder containing probiotics that the present invention is provided, the milk powder raw material include original
Material breast 14.75%, lactose 37.64%, mixed vegetable oil 26.55%, active probiotic freeze-dried powder 0.25%, WPC
12.29%, prebiotics 4.43%, bioactivator 0.8%, B B-complex 0.3%, composite mineral matter 0.30%, insatiable hunger
With aliphatic acid 1.97%, additives 0.17%, sodium chloride 0.20%, potassium chloride 0.25%, calcium carbonate 0.39%, balance of water,
It is the amount for being converted into corresponding whole-fat milk powder and/or skimmed milk powder during the raw milk calculating percentage；Described percentage is each
Component accounts for the mass percent containing milk powder raw material.
The active probiotic freeze-dried powder is the freeze-dried powder of bifidobacterium lactis Bi-07；The desalted whey powder is D80；Institute
The WPC stated is WPI；Described prebiotics be oligoisomaltose, FOS, galactooligosaccharide, poly really
Sugar, lactulose, xylo-oligosaccharide mix in any proportion；
Bioactivator is lactoferrin, immunoglobulin, sialic acid mix in any proportion；
The composite mineral matter, every 100 grams of mineral matter cupric 330mg；Magnesium 4129mg；Iron 3678mg；Zinc 3254mg；
Manganese 38mg；Iodine 62mg；Selenium 15mg；
The unsaturation is aliphatic acid, and any ratio is pressed from arachidonic acid, DHA, linoleic acid, leukotrienes
Example mixing；
The additives are that taurine, nucleotides and choline mix according to arbitrary proportion.
Further, the water activity of milk powder is 0.2.
The method for preparing said milk powder, comprises the following steps, (1) is sterilized by raw milk, obtains the raw milk after sterilization；With
Raw milk solubilized lactose after sterilization, desalted whey powder, WPC, mixed vegetable oil, prebiotics；It is pre-dissolved with water compound
Vitamin, composite mineral matter is well mixed after additives with raw milk, hydration, obtains feed liquid A；
(2) sterilized by feed liquid A homogeneous, concentration, spray drying obtains material B；
(3) material B is well mixed i.e. with bioactivator, unrighted acid and active probiotic in dry-mixed workshop
Obtain milk powder.
In step (1), described water is deionized water；
It is usually pasteurize that described raw milk is sterilized；
Described being mixed into typically is carried out in batch mixer；
Mix with raw milk again after first being premixed before the mixing of the lactose, desalted whey powder, WPC and prebiotics
Uniformly；
40~50 DEG C are first heated to before the mixed vegetable oil mixing；
The water is pre-dissolved B B-complex, composite mineral matter and additives, if the consumption of the water can make it is described multiple
Vitamin, composite mineral matter, optional material is closed to disperse in water and well mixed.
In step (2), described homogenization pressure is 15~25MPa, and the homogenizing temperature is 55~65 DEG C.
Described sterilized temperature is 85~95 DEG C, and the sterilizing time is 15~25 seconds；
Thickening temperature described in described concentration is 40-50 DEG C, and the terminal of the concentration is to be concentrated into solid content
42~48%, the percentage is mass percent；
The EAT of the spray drying is 165~190 DEG C, and the temperature of outgoing air of the spray drying is 80~95 DEG C,
The spray drying also includes fluidized bed drying, and the fluidized bed drying goes out powder temperature for 30~40 DEG C.
In step (3), the method for the mixing is two-stage or three-level dilution method, and the mixing is first by biological active matter
Matter, unrighted acid, active probiotic press 1 with material B respectively:8~12 premixs, the ratio is mass ratio, is then entered again
Row two-stage or three-level are dry-mixed.
The dry-mixed environment temperature is 20~30 DEG C, and the dry-mixed relative humidity is 35%~50%, the percentage
Than being pressure percentage.
Answer first equilibrium temperature consistent with dry-mixed workshop condition temperature before the dry-mixed raw material is dry-mixed.
According to target probiotics addition, the theoretical addition that Bifidobacterium Bi-07 is obtained is respectively 1.5 × 107cfu/
G, 3.0 × 107Cfu/g and 6.0 × 107The milk powder of cfu/g.
Addition is as follows for the influence verification method of probiotic stability：
(1) the different prescription emulsifiable powder of probiotics addition is placed on 42 DEG C of temperature, the constant temperature and humidity of relative humidity 75%
In incubator, in the 0th, 2,4,6,8,10,12 weeks sampling detection viable counts, stability of the checking addition for probiotics.
(2) viable count detection method：Taken out from insulating box and treat that test sample is positioned over 1~2 hour at room temperature, balance its temperature
It is consistent with room temperature.Weigh 25g samples shaken well in 225mL physiological saline.Absorption 1mL is added to 9mL centrifuge tubes, and (concentration is i.e.
It is 10-2) 10 times of gradient dilutions are carried out step by step, the solution 0.2mL for choosing appropriate dilution carries out pouring into experiment.MRS agar cultures
Base uses first 121 DEG C, 15min sterilizings.After pour plate solidification, it is placed in 37 DEG C of anaerobic culture boxes and cultivates 48h.Choose bacterium colony
Culture dish of the number between 30~300 is counted.Addition is shown in Table 3 for the influence of probiotic stability
Table 3
From the data of table 3, under 42 DEG C of Acceleration studies, its viable count in milk powder can be for probiotics Bi-07
Decline, but have no the decline of countless magnitudes.Therefore order of magnitude when dispatching from the factory is reached to ensure the survival volume of probiotics, it is proposed that containing benefit
Raw bacterium viable count control is 3 × 107CFU/g or so.
Example IV：A kind of neonate's prescription emulsifiable powder containing probiotics that the present invention is provided, the milk powder raw material include original
Material breast 15.72%, lactose 41.28%, mixed vegetable oil 23.59%, active probiotic freeze-dried powder 0.15%, WPC
10.81%, prebiotics 4.42%, bioactivator 0.7%, B B-complex 0.6%, composite mineral matter 0.30%, insatiable hunger
With aliphatic acid 1.57%, additives 0.17%, sodium chloride 0.20%, potassium chloride 0.35%, calcium carbonate 0.29%, balance of water,
It is the amount for being converted into corresponding whole-fat milk powder and/or skimmed milk powder during the raw milk calculating percentage；Described percentage is each
Component accounts for the mass percent containing milk powder raw material.
The active probiotic freeze-dried powder is bifidobacterium bifidum, bifidobacterium infantis, bifidobacterium adolescentis, short bifid bar
Bacterium, bifidobacterium lactis, bifidobacterium longum, animal bifidobacteria, lactobacillus acidophilus, Lactobacillus rhamnosus mix in any proportion；
The desalted whey powder is D90；The WPC is WPC80；Described prebiotics is oligomeric different malt
Sugar, FOS, galactooligosaccharide, polyfructosan, lactulose, xylo-oligosaccharide mix in any proportion；
Bioactivator is lactoferrin, immunoglobulin, sialic acid mix in any proportion；
The composite mineral matter, every 100 grams of mineral matter cupric 224mg；Magnesium 3640mg；Iron 2800mg；Zinc 2800mg；
Manganese 27.5mg；Iodine 55.5mg；Selenium 12mg；
The unsaturation is aliphatic acid, and any ratio is pressed from arachidonic acid, DHA, linoleic acid, leukotrienes
Example mixing；
The additives are that taurine, nucleotides and choline mix according to arbitrary proportion.
Further, the water activity of milk powder is 0.18.
The method for preparing said milk powder, comprises the following steps, (1) is sterilized by raw milk, obtains the raw milk after sterilization；With
Raw milk solubilized lactose after sterilization, WPC, mixed vegetable oil, prebiotics；B B-complex is pre-dissolved with water, is combined
Mineral matter, is well mixed after additives with raw milk, hydration, obtains feed liquid A；
(2) sterilized by feed liquid A homogeneous, concentration, spray drying obtains material B；
(3) material B is well mixed i.e. with bioactivator, unrighted acid and active probiotic in dry-mixed workshop
Obtain milk powder.
In step (1), described water is deionized water；
It is usually pasteurize that described raw milk is sterilized；
Described being mixed into typically is carried out in batch mixer；
It is well mixed with raw milk again after first being premixed before the mixing of the lactose, WPC and prebiotics；
40~50 DEG C are first heated to before the mixed vegetable oil mixing；
The water is pre-dissolved B B-complex, composite mineral matter and additives, if the consumption of the water can make it is described multiple
Vitamin, composite mineral matter, optional material is closed to disperse in water and well mixed.
In step (2), described homogenization pressure is 15~25MPa, and the homogenizing temperature is 55~65 DEG C.
Described sterilized temperature is 85~95 DEG C, and the sterilizing time is 15~25 seconds；
Thickening temperature described in described concentration is 40-50 DEG C, and the terminal of the concentration is to be concentrated into solid content
42~48%, the percentage is mass percent；
The EAT of the spray drying is 165~190 DEG C, and the temperature of outgoing air of the spray drying is 80~95 DEG C,
The spray drying also includes fluidized bed drying, and the fluidized bed drying goes out powder temperature for 30~40 DEG C.
In step (3), the method for the mixing is two-stage or three-level dilution method, and the mixing is first by biological active matter
Matter, unrighted acid, active probiotic press 1 with material B respectively:8~12 premixs, the ratio is mass ratio, is then entered again
Row two-stage or three-level are dry-mixed.
The dry-mixed environment temperature is 20~30 DEG C, and the dry-mixed relative humidity is 35%~50%, the percentage
Than being pressure percentage.
Answer first equilibrium temperature consistent with dry-mixed workshop condition temperature before the dry-mixed raw material is dry-mixed.
Neonate's prescription emulsifiable powder and 3 sections of commercial infant prescription emulsifiable powders to embodiment 1-4 containing probiotics (as control)
Carry out sensory evaluation.Sensory evaluation index is the brew and taste smell of milk powder.Milk powder brew and taste odor evaluations method are such as
Under：Ask 12 sense organ criticism personnel to carry out above-mentioned 6 groups of samples brew respectively to be evaluated with smell is grown, evaluation method is blind
Sample (6 groups of sample random labellings are a, b, c, d, e, f).Specific evaluation criterion is as shown in table 4.
The evaluation criterion of the sensory evaluation of table 4
The Analyses Methods for Sensory Evaluation Results of table 5
The milk powder sensory evaluation and the evaluation of in the market infant's powder produced from the sensory results of table 5, embodiment 1-4
In identical rank, and sensory scores are higher.This explanation embodiment milk powder sense organ is good.
The preferred embodiments of the present invention are the foregoing is only, is not intended to limit the invention, for the skill of this area
For art personnel, the present invention can have various modifications and variations.It is all within the spirit and principles in the present invention, made any repair
Change, equivalent, improvement etc., should be included within the scope of the present invention.
Claims (10)
1. a kind of neonate's prescription emulsifiable powder containing probiotics, it is characterised in that the milk powder raw material include raw milk 14.75~
29.97%, lactose 18.36~41.28%, mixed vegetable oil 16.40~26.55%, active probiotic freeze-dried powder 0.06~
0.25%, state raw milk calculate percentage when be the amount for being converted into corresponding whole-fat milk powder and/or skimmed milk powder；Described percentage
For each component accounts for the mass percent containing milk powder raw material.
2. neonate's prescription emulsifiable powder of probiotics is contained according to claim 1, it is characterised in that raw material also include desalination breast
Clear powder 0.00~30.89%, WPC 4.48~12.29%, prebiotics 2.09~4.43%, bioactivator
0.41~0.80%, B B-complex 0.3~0.8%, composite mineral matter 0.15~0.30%, unrighted acid 1.19~
3.99%, additives 0.07~0.37%, described percentage accounts for the mass percent of milk powder raw material for each component.
3. neonate's prescription emulsifiable powder of probiotics is contained according to claim 1, it is characterised in that raw material include sodium chloride
0.00~0.55%, potassium chloride 0.00~0.35%, calcium carbonate 0.00~0.39%, described percentage accounts for milk powder for each component
The mass percent of raw material.
4. neonate's prescription emulsifiable powder of probiotics is contained according to claim 1, it is characterised in that the active probiotic is freezed
Powder be bifidobacterium bifidum, bifidobacterium infantis, bifidobacterium adolescentis, bifidobacterium breve, bifidobacterium lactis, bifidobacterium longum,
One or more in animal bifidobacteria, lactobacillus acidophilus, Lactobacillus rhamnosus.
5. the neonate's prescription emulsifiable powder containing probiotics according to claim 2, it is characterised in that the desalted whey powder is
In D70, D80, D90 any one；
And/or, described WPC is one or more in WPC75, WPC80 and WPI, and/or is preferably concentrated
Lactalbumin is that protein content is 80%~82%, the concentrated whey protein powder of alpha lactalbumin >=25%, the percentage
It is mass percent；And/or described prebiotics be selected from oligoisomaltose, FOS, galactooligosaccharide, polyfructosan,
One or more in lactulose, xylo-oligosaccharide；
And/or the bioactivator be selected from lactoferrin, immunoglobulin, sialic acid one or more；
And/or the composite mineral matter, 224~336mg of every 100 grams of mineral matter cuprics；3640~5460mg of magnesium；Iron 2800
~4200mg；2800~4200mg of zinc；27.5~45.0mg of manganese；55.5~83.0mg of iodine；12~18mg of selenium；
And/or the unrighted acid, from arachidonic acid, DHA, one kind of linoleic acid plus linolenic acid or
More than one；
And/or the additives be taurine, nucleotides and choline in one or more.
6. the neonate's prescription emulsifiable powder containing probiotics according to claim 1, it is characterised in that the water activity of milk powder is
0.15~0.25.
7. a kind of method for preparing the prescription emulsifiable powder of neonate containing probiotics described in claim 1-6 any one, it is characterised in that
The method comprises the following steps that (1) is sterilized by raw milk, obtains the raw milk after sterilization；Breast is dissolved with the raw milk after sterilization
Sugar, desalted whey powder, WPC, mixed vegetable oil, prebiotics；B B-complex is pre-dissolved with water, composite mineral matter is attached
Plus be well mixed with raw milk after agent, it is hydrated, obtain feed liquid A；
(2) sterilized by feed liquid A homogeneous, concentration, spray drying obtains material B；
(3) material B is well mixed with bioactivator, unrighted acid and active probiotic in dry-mixed workshop and obtains final product breast
Powder.
8. the method for preparing the prescription emulsifiable powder of neonate containing probiotics according to claim 7, it is characterised in that in step (1),
Described water is deionized water；
And/or, described raw milk sterilization is pasteurize；
And/or, described being mixed into is carried out in batch mixer；
And/or, it is mixed with raw milk again after first being premixed before the mixing of the lactose, desalted whey powder, WPC and prebiotics
Close uniform；
And/or, first it is heated to 40~50 DEG C before the mixed vegetable oil mixing；
And/or, the water is pre-dissolved B B-complex, composite mineral matter and additives, as long as the consumption of the water can make it is described
B B-complex, composite mineral matter, optional material disperse and well mixed in water.
9. the method for preparing the prescription emulsifiable powder of neonate containing probiotics according to claim 7, it is characterised in that in step (2),
Described homogenization pressure is 15~25MPa, and the homogenizing temperature is 55~65 DEG C；
And/or, described sterilized temperature is 85~95 DEG C, and the sterilizing time is 15~25 seconds；
And/or, the thickening temperature described in described concentration is 40~50 DEG C, and the terminal of the concentration is to be concentrated into solid content
It is 42~48%, the percentage is mass percent；
And/or, the EAT of the spray drying is 165~190 DEG C, and the temperature of outgoing air of the spray drying is 80~95
DEG C, the spray drying also includes fluidized bed drying, and the fluidized bed drying goes out powder temperature for 30~40 DEG C.
10. the method for preparing the prescription emulsifiable powder of neonate containing probiotics according to claim 7, it is characterised in that step (3)
In, the method for the mixing is two-stage or three-level dilution method, the mixing first by bioactivator, unrighted acid,
Active probiotic presses 1 with material B respectively:8~12 premixs, the ratio is mass ratio, then carries out two-stage again or three-level is dry-mixed；
And/or, the dry-mixed environment temperature is 20~30 DEG C, and the dry-mixed relative humidity is 35%~50%, described hundred
Divide than being pressure percentage；
And/or, answer first equilibrium temperature consistent with dry-mixed workshop condition temperature before the dry-mixed raw material is dry-mixed.
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| CN110839698A (en) * | 2019-11-29 | 2020-02-28 | 内蒙古伊利实业集团股份有限公司 | Composition and food application thereof |
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