CN111587923A - An infant formula containing sialic acid and its preparation method - Google Patents
An infant formula containing sialic acid and its preparation method Download PDFInfo
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Abstract
The invention belongs to the field of formula foods, and relates to an infant formula food containing sialic acid, wherein the infant formula food containing sialic acid is prepared from the following raw materials in parts by weight: the formula food has the effects of treating diarrhea, promoting absorption of nutrient components and regulating intestinal flora.
Description
Technical Field
The invention belongs to the technical field of infant formula foods, and particularly relates to an infant formula food containing sialic acid and a preparation method thereof.
Background
Sialic Acid (SA) is a group of neuraminic acid derivatives of acidic nine-carbon monosaccharides, which mainly exist in free sialic acid, polysialic acid, sialic acid derivatives and sialic acid homologues. The content of sialic acid in mother milk is 0.3-1.5 g/L, the content of sialic acid in other mammal milk is very low, the content of sialic acid in cow milk is 80-760 mu g/mL, the main existing forms of sialic acid in the mother milk and cow milk are different, the main existing form of sialic acid in the mother milk is a form combined with oligosaccharide, namely sialic acid oligosaccharide, the main existing form of sialic acid in cow milk is a form combined with protein, and the mature cow milk only contains a small amount of sialic acid combined with oligosaccharide. Many infants cannot be breastfed due to the physical aspects of the mother, etc., and infant formula is the best choice other than breast milk, so that the addition of sialic acid to infant formula can promote the development of the nervous system and brain of the infant.
In the infant stage, incomplete establishment of the intestinal flora can lead to infantile diarrhea due to incomplete intestinal development. The infant noninfectious diarrhea is mostly caused by lactose intolerance and milk protein allergy, but the common diarrhea-preventing milk powder in the current infant formula milk powder market is only suitable for a few infants who are allergic to milk protein or lactose in the past, and most infant series milk powder causes the burden of the infant digestive system due to the increase of the protein content, so that the infant constipation and other gastrointestinal tract digestive problems are easily caused, and the milk powder capable of meeting the lactose requirement and improving the gastrointestinal tract digestive ability is not provided.
Disclosure of Invention
The invention aims to provide an infant formula containing sialic acid, wherein the components of the infant formula, particularly the sialic acid existing form, are closer to breast milk, the feeding effect is also closer to the breast milk, the infant formula is more suitable for Asian infants, particularly Chinese (Chinese) infants, and the immunity of the infants can be improved.
In order to achieve the purpose, the invention adopts the following technical scheme:
an infant formula containing sialic acid, wherein the infant milk powder containing sialic acid is prepared from the following raw materials in percentage by mass: 1300-1800 parts of alpha-lactalbumin, 3000-4560 parts of beta-casein, 2500-4800 parts of milk fat globule membrane protein, 20-60 parts of lactoferrin, 3000-5000 parts of human milk oligosaccharide, 3000-3000 parts of sialic acid, 30000-35000 parts of lactose, 28000 parts of edible plant blend oil, 6000 parts of vitamin complex 4000-6000 parts, 1200-1800 parts of mineral, 10-60 parts of nucleotide, 200-600 parts of a mixture microencapsulated DHA and ARA, 5-50 parts of bifidobacterium lactis, 800-1600 parts of galactooligosaccharide, 1600 parts of fructooligosaccharide, 800-1600 parts of inulin oligosaccharide and 10-30 parts of immunoglobulin.
Preferably, the sialic acid-containing infant milk powder is prepared from the following raw materials in parts by weight: alpha-lactalbumin 2050 parts, beta-casein 3780 parts, milk fat globule membrane protein 3650 parts, lactoferrin powder 40 parts, human milk oligosaccharide 4000 parts, sialic acid 2000 parts, lactose 32500 parts, edible plant blend oil 25500 parts, vitamin complex 5000 parts, mineral matter 1500 parts, nucleotide 35 parts, DHA (docosahexaenoic acid) and ARA (arachidonic acid) microencapsulated mixture 400 parts, bifidobacterium lactis 27.5 parts, galacto-oligosaccharide 1200 parts, fructo-oligosaccharide 1200 parts, inulin-oligosaccharide 1200 parts and immunoglobulin 20 parts.
Preferably, the human milk oligosaccharide consists of 2' -fucosyllactose, 3' -sialyllactose, 6' -sialyllactose.
Preferably, the edible vegetable blend oil is composed of rapeseed oil, corn oil, coconut oil, sunflower seed oil, soybean oil, 1, 3-dioleate 2-palmitic acid triglyceride, palm kernel oil and linseed oil.
Preferably, the vitamins consist of vitamin a, vitamin D, vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C, biotin, choline, l-carnitine, inositol, bovine iodic acid, lutein.
Preferably, the nucleotide is adenine nucleotide, guanine nucleotide, cytosine nucleotide, uracil nucleotide, hypoxanthine nucleotide.
Preferably, the mineral is selected from calcium carbonate, potassium chloride, tricalcium phosphate, copper gluconate, ferrous gluconate, zinc sulfate, magnesium sulfate, manganese sulfate, potassium iodide and sodium selenite.
It is a further object of the present invention to provide a method for preparing an infant formula containing sialic acid, said method comprising the steps of:
s1, weighing the raw materials according to a formula ratio, and dissolving alpha-lactalbumin, beta-casein, milk fat globule membrane protein, lactoferrin powder, human milk oligosaccharide, lactose, edible plant blend oil, galacto-oligosaccharide, fructo-oligosaccharide and inulin oligosaccharide in water at the temperature of 40-45 ℃ according to a ratio to obtain a mixed solution 1, wherein the temporary storage time of the mixed solution 1 is not more than 6 hours;
s2, weighing mineral substances, nucleotide and sialic acid according to a formula ratio, adding the mineral substances, the nucleotide and the sialic acid into the mixed solution 1 in sequence, stirring and dissolving for 10-30 minutes, adding vitamins, stirring and dissolving for 10-30 minutes at the stirring speed of 500-700rpm, filtering the mixed material liquid through a filter screen to obtain a mixed solution 2, wherein the temporary storage time of the mixed solution 2 is not more than 6 hours; sterilizing the mixed solution 2;
s3, homogenizing the sterilized mixed solution 2 by using a high-pressure homogenizer at 20-25MPa, controlling the temperature at 40-45 ℃, concentrating and spray drying to obtain powder, wherein the air inlet temperature of spray drying is 150-160 ℃, and the air exhaust temperature is 70-80 ℃ to obtain powdery base powder;
s4, adding sterilized immunoglobulin and bifidobacteria into the powder base powder, mixing uniformly, sieving, charging nitrogen in vacuum, and finally packaging in a sterilized powder storage tank.
The invention has the following advantages:
(1) the invention provides an infant formula food containing sialic acid, and human milk oligosaccharide and milk fat globule membrane protein are added, and experimental example 2 proves that the addition of sialic acid, human milk oligosaccharide and milk fat globule membrane protein can synergistically reduce the occurrence of infant diarrhea, synergistically promote the regulation of intestinal flora, effectively improve respiratory tract infection and improve infant immunity.
(4) The invention is based on the nutritional requirements of infants, and scientifically adds the desalted whey powder, the OPO structural fat, the lactose, the oligosaccharide, the lactoferrin, the docosahexaenoic acid, the arachidonic acid, the taurine, the choline, the nucleotide, the inositol, the L-carnitine, the compound vitamin and the compound mineral substance, can well promote the development of intelligence and eyesight of the infants, simultaneously improve the digestive absorption function of intestinal tracts of the infants, improve the intestinal flora by adding the oligosaccharide, effectively inhibit the growth of harmful intestinal products and pathogenic bacteria, thereby ensuring the virus resistance of the intestinal tracts, reasonably adds the lactoferrin component, can increase and promote the iron absorption of the intestinal tracts, simultaneously enhance the immunity of the infants, adds the taurine and the nucleotide, is beneficial to the development of brain and nervous systems of newborns, adds the choline to promote the brain development and improve the memory capacity, inositol and L-carnitine are also added to promote fat metabolism, so that the infant formula milk powder has comprehensive and multifunctional nutrition and more similar components, content and functions to breast milk.
Detailed Description
The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.
Example 1
An infant formula containing sialic acid, wherein the infant milk powder containing sialic acid is prepared from the following raw materials in percentage by mass: 1300 parts of alpha-lactalbumin, 4560 parts of beta-casein, 4800 parts of milk fat globule membrane protein, 5000 parts of human milk oligosaccharide, 60 parts of lactoferrin, 3000 parts of sialic acid, 35000 parts of lactose, 27000 parts of edible plant blend oil, 60 parts of vitamin complex, 1800 parts of mineral substances, 60 parts of nucleotide, 600 parts of a mixture microencapsulated DHA and ARA, 50 parts of bifidobacterium lactis, 1600 parts of galacto-oligosaccharide, 1600 parts of fructo-oligosaccharide, 1600 parts of inulin oligosaccharide and 30 parts of immunoglobulin.
The preparation method comprises the following steps:
s1, weighing the raw materials according to a formula ratio, and dissolving alpha-lactalbumin, beta-casein, milk fat globule membrane protein, lactoferrin powder, human milk oligosaccharide, lactose, edible plant blend oil, galacto-oligosaccharide, fructo-oligosaccharide and inulin oligosaccharide in water at the temperature of 40-45 ℃ according to a ratio to obtain a mixed solution 1, wherein the temporary storage time of the mixed solution 1 is not more than 6 hours;
s2, weighing mineral substances, nucleotide and sialic acid according to a formula ratio, adding the mineral substances, the nucleotide and the sialic acid into the mixed solution 1 in sequence, stirring and dissolving for 10-30 minutes, adding vitamins, stirring and dissolving for 10-30 minutes at the stirring speed of 500-700rpm, filtering the mixed material liquid through a filter screen to obtain a mixed solution 2, wherein the temporary storage time of the mixed solution 2 is not more than 6 hours; sterilizing the mixed solution 2;
s3, homogenizing the sterilized mixed solution 2 by using a high-pressure homogenizer at 20-25MPa, controlling the temperature at 40-45 ℃, concentrating and spray drying to obtain powder, wherein the air inlet temperature of spray drying is 150-160 ℃, and the air exhaust temperature is 70-80 ℃ to obtain powdery base powder;
s4, adding sterilized immunoglobulin and bifidobacteria into the powder base powder, mixing uniformly, sieving, charging nitrogen in vacuum, and finally packaging in a sterilized powder storage tank.
Example 2
An infant formula containing sialic acid, wherein the infant milk powder containing sialic acid is prepared from the following raw materials in percentage by mass: 1800 parts of alpha-lactalbumin, 3000 parts of beta-casein, 2500 parts of milk fat globule membrane protein, 3000 parts of human milk oligosaccharide, 20 parts of lactoferrin, 3000 parts of sialic acid, 30000 parts of lactose, 24000 parts of edible plant blend oil, 40 parts of multivitamin, 1500 parts of mineral matter, 35 parts of nucleotide, 400 parts of a mixture microencapsulated DHA and ARA, 27.5 parts of bifidobacterium lactis, 1200 parts of galacto-oligosaccharide, 1200 parts of fructo-oligosaccharide, 1200 parts of inulin-oligosaccharide and 20 parts of immunoglobulin.
The preparation method is the same as example 1.
Example 3
An infant formula containing sialic acid, wherein the infant milk powder containing sialic acid is prepared from the following raw materials in percentage by mass: 1550 parts of alpha-lactalbumin, 3780 parts of beta-casein, 3650 parts of milk fat globule membrane protein, 4000 parts of human milk oligosaccharide, 40 parts of lactoferrin, 2000 parts of sialic acid, 32500 parts of lactose, 25500 parts of edible plant blend oil, 40 parts of vitamin complex, 1800 parts of mineral substances, 10 parts of nucleotide, 200 parts of a mixture microencapsulated DHA and ARA, 5 parts of bifidobacterium lactis, 800 parts of galacto-oligosaccharide, 800 parts of fructo-oligosaccharide, 800 parts of inulin-oligosaccharide and 10 parts of immunoglobulin.
The preparation method is the same as example 1.
Comparative example 1
Compared with the example 3, the comparative example has no milk fat globule membrane protein, really has part of the mass part supplemented by the human milk oligosaccharide, and the types and the contents of the other components are consistent with the example 3.
Comparative example 2
Compared with the example 3, the comparative example has no human milk oligosaccharide, a certain part of the mass parts are supplemented by milk fat globule membrane protein, and the types and the contents of the other components are consistent with the example 3.
Comparative example 3
Compared with the example 3, the comparative example has no sialic acid added, the parts with the mass are supplemented by 24 to 27 percent of edible vegetable blend oil, and the types and the contents of the other components are consistent with those of the example 3.
Comparative example 4
Compared with the example 3, the comparative example does not add milk fat globule membrane protein and human milk oligosaccharide, ensures that partial mass parts are supplemented with sialic acid, and keeps the types and the contents of the other components consistent with the example 3.
Comparative example 5
Compared with the example 3, the comparative example does not add milk fat globule membrane protein and sialic acid, ensures that partial mass part is supplemented with the human milk oligosaccharide, and keeps the types and the contents of the other components consistent with the example 3.
Comparative example 6
Compared with the example 3, the comparative example has no addition of human milk oligosaccharide and sialic acid, ensures that the weight part of the part is supplemented with 20-30% of milk fat globule membrane protein, and keeps the types and the contents of the other components consistent with the example 3.
Comparative example 7
Compared with the example 3, the comparative example does not add human milk oligosaccharide, milk fat globule membrane protein and sialic acid, ensures that the parts with mass are supplemented by 24 to 27 percent of edible vegetable blend oil, and keeps the types and the contents of the other components consistent with the example 3.
Experimental example curative effect on diarrhea and gastrointestinal tract digestibility
The method comprises the following steps: the method comprises the steps of adopting 5d SPF-grade Kunming suckling mice, male animals, feeding ampicillin for 15g/Kg8 h before an experiment, feeding Shigella flexneri dysentery bacillus and Salmonella typhimurium for modeling, taking the milk powder of examples 1-3 and comparative examples 1-7, observing the diarrhea condition, intestinal flora condition and normal growth condition of the mice, killing the mice after feeding for 14 days, quickly cutting open the abdominal cavity, taking out the stomach and duodenum, storing the small intestine in an ice box, and measuring the digestibility of fat, lactose and protein.
1.1 therapeutic results on diarrhea
And (3) detecting the diarrhea index: and (4) judging diarrhea, wherein the feces are scored according to the color and the form of the feces of the suckling mice, and the score is 0-4. 0 minute: no excrement is produced; 1 minute: normal stool; and 2, dividing: yellowish soft stool; and 3, dividing: light yellow and thin stool; and 4, dividing: water sample is easy. A score of greater than or equal to 2 is considered diarrhea.
The body weight and diarrhea changes of the mice in each group are shown in table 1, and the results show that the mice fed with the formula of examples 1-3 have diarrhea degree which is significantly lower than that of the mice fed with the infant formula of comparative examples 1-8, wherein the diarrhea degree of example 3 is 1.0, no diarrhea and higher weight gain, which shows that the infant formula simultaneously added with the asialo, the milk fat globule membrane protein and the human milk oligosaccharide can effectively treat the diarrhea of the mice and promote the growth of the mice compared with the asialo, the milk fat globule membrane protein and the human milk oligosaccharide which are added separately, and shows that the sialic acid, the milk fat globule membrane protein and the human milk oligosaccharide can synergistically treat the diarrhea caused by Shigella flexneri dysentery bacterium and Salmonella typhimurium.
TABLE 1 mouse weight and diarrhea Change
| Average body weight (g) after 7 days | Average body weight (g) after 14 days | Average weight gain (g) | Degree of diarrhea | |
| Example 1 | 6.52 | 12.2 | 5.68 | 1.1 |
| Example 2 | 6.53 | 12.5 | 5.97 | 1.2 |
| Example 3 | 6.46 | 13.76 | 7.3 | 1.0 |
| Comparative example 1 | 5.82 | 8.62 | 2.8 | 2.2 |
| Comparative example 2 | 5.72 | 8.64 | 2.92 | 2.3 |
| Comparative example 3 | 5.97 | 7.81 | 1.84 | 2.5 |
| Comparative example 4 | 5.64 | 7.63 | 1.99 | 3 |
| Comparative example 5 | 5.63 | 7.58 | 1.95 | 3.2 |
| Comparative example 6 | 5.12 | 7.54 | 2.42 | 3.4 |
| Comparative example 7 | 5.06 | 6.99 | 1.93 | 4 |
1.2 effects on Nutrition Performance in mice
1) Determination of fat digestibility
The digestive tract is flushed by normal saline, gastric juice and intestinal juice are collected in the normal saline, and the fat content in each sample is determined by an acid hydrolysis method.
2) Determination of lactose digestibility
The digestive tract is flushed with normal saline, gastric juice and intestinal juice are collected in the normal saline, and the lactose content in each sample is measured by the Rionene-Ke agricultural method.
3) Determination of protein digestibility
The digestive tract is flushed by normal saline, gastric juice and intestinal juice are collected in the normal saline, and the content of protein in each sample is measured by a Kjeldahl method.
The test results are shown in table 2, and the results show that compared with mice fed with the infant formula milk powder added with the sialic acid, the milk fat globule membrane protein and the human milk oligosaccharide alone, the fat digestibility, the lactose digestibility and the protein digestibility of the mice fed with the infant formula milk powder added with the sialic acid, the milk fat globule membrane protein and the human milk oligosaccharide are remarkably increased, and the sialic acid, the milk fat globule membrane protein and the human milk oligosaccharide have a synergistic promoting effect on the nutrition of the mice and are absent.
TABLE 2 digestibility measurements
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (8)
1. An infant formula containing sialic acid, which is characterized in that the infant milk powder containing sialic acid is prepared from the following raw materials in parts by weight: 1300-1800 parts of alpha-lactalbumin, 3000-4560 parts of beta-casein, 2500-4800 parts of milk fat globule membrane protein, 20-60 parts of lactoferrin, 3000-5000 parts of human milk oligosaccharide, 3000-3000 parts of sialic acid, 30000-35000 parts of lactose, 28000 parts of edible plant blend oil, 6000 parts of vitamin complex 4000-6000 parts, 1200-1800 parts of mineral, 10-60 parts of nucleotide, 200-600 parts of a mixture microencapsulated DHA and ARA, 5-50 parts of bifidobacterium lactis, 800-1600 parts of galactooligosaccharide, 1600 parts of fructooligosaccharide, 800-1600 parts of inulin oligosaccharide and 10-30 parts of immunoglobulin.
2. The infant formula of claim 1, wherein the sialic acid containing infant milk powder is prepared from the following raw materials in parts by weight: alpha-lactalbumin 2050 parts, beta-casein 3780 parts, milk fat globule membrane protein 3650 parts, lactoferrin powder 40 parts, human milk oligosaccharide 4000 parts, sialic acid 2000 parts, lactose 32500 parts, edible plant blend oil 25500 parts, vitamin complex 5000 parts, mineral matter 1500 parts, nucleotide 35 parts, DHA (docosahexaenoic acid) and ARA (arachidonic acid) microencapsulated mixture 400 parts, bifidobacterium lactis 27.5 parts, galacto-oligosaccharide 1200 parts, fructo-oligosaccharide 1200 parts, inulin-oligosaccharide 1200 parts and immunoglobulin 20 parts.
3. The infant formula of claim 1, wherein the human milk oligosaccharide consists of 2' -fucosyllactose, 3' -sialyllactose, 6' -sialyllactose in a mass ratio of 10:6:4: 1.
4. The infant formula of claim 1, wherein the edible vegetable blend oil is comprised of 1, 3-dioleate 2-palmitate triglyceride, canola oil, corn oil, coconut oil, sunflower oil, soybean oil, palm kernel oil, linseed oil.
5. The infant formula of claim 1, wherein the vitamins consist of vitamin a, vitamin D, vitamin E, vitamin K1, vitamin B1, vitamin B2, vitamin B6, vitamin B12, niacin, folic acid, pantothenic acid, vitamin C and biotin, choline, l-carnitine, inositol, boiodic acid, lutein.
6. The infant formula of claim 1, wherein the nucleotides are adenine nucleotides, guanine nucleotides, cytosine nucleotides, uracil nucleotides, and inosinic nucleotides.
7. The infant formula of claim 1, wherein the minerals are comprised of calcium carbonate, potassium chloride, tricalcium phosphate, copper gluconate, ferrous gluconate, zinc sulfate, magnesium sulfate, manganese sulfate, potassium iodide, and sodium selenite.
8. A process for the preparation of an infant formula containing sialic acid as claimed in any one of claims 1 to 7, comprising the steps of:
s1, weighing the raw materials according to a formula ratio, and dissolving alpha-lactalbumin, beta-casein, milk fat globule membrane protein, lactoferrin powder, human milk oligosaccharide, lactose, edible plant blend oil, galacto-oligosaccharide, fructo-oligosaccharide and inulin oligosaccharide in water at the temperature of 40-45 ℃ according to a ratio to obtain a mixed solution 1, wherein the temporary storage time of the mixed solution 1 is not more than 6 hours;
s2, weighing mineral substances, nucleotide and sialic acid according to a formula ratio, adding the mineral substances, the nucleotide and the sialic acid into the mixed solution 1 in sequence, stirring and dissolving for 10-30 minutes, adding vitamins, stirring and dissolving for 10-30 minutes at the stirring speed of 500-700rpm, filtering the mixed material liquid through a filter screen to obtain a mixed solution 2, wherein the temporary storage time of the mixed solution 2 is not more than 6 hours; sterilizing the mixed solution 2;
s3, homogenizing the sterilized mixed solution 2 by using a high-pressure homogenizer at 20-25MPa, controlling the temperature at 40-45 ℃, concentrating and spray drying to obtain powder, wherein the air inlet temperature of spray drying is 150-160 ℃, and the air exhaust temperature is 70-80 ℃ to obtain powdery base powder;
s4, adding sterilized immunoglobulin and bifidobacteria into the powder base powder, mixing uniformly, sieving, charging nitrogen in vacuum, and finally packaging in a sterilized powder storage tank.
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| CN112998239A (en) * | 2021-04-14 | 2021-06-22 | 淮南新能源研究中心 | Fermented bean curd powder and preparation method and application thereof |
| CN113841740A (en) * | 2021-09-06 | 2021-12-28 | 内蒙古伊利实业集团股份有限公司 | Sialic acid-containing infant formula milk powder and preparation method thereof |
| CN114145353A (en) * | 2021-11-30 | 2022-03-08 | 内蒙古伊利实业集团股份有限公司 | Formula milk powder capable of improving intestinal microenvironment health and preparation method and application thereof |
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