CN113841740A

CN113841740A - Sialic acid-containing infant formula milk powder and preparation method thereof

Info

Publication number: CN113841740A
Application number: CN202111037867.0A
Authority: CN
Inventors: 赵红霞; 刘彪; 李威; 孔小宇; 周名桥
Original assignee: Inner Mongolia Yili Industrial Group Co Ltd
Current assignee: Inner Mongolia Yili Industrial Group Co Ltd
Priority date: 2021-09-06
Filing date: 2021-09-06
Publication date: 2021-12-28

Abstract

The invention provides sialic acid-containing infant formula milk powder and a preparation method thereof. The infant formula milk powder contains 0.3-1% of milk fat globule membrane, and 0.1-0.5% of casein glycomacropeptide. The milk fat globule membrane and the casein glycomacropeptide are added into the infant formula milk powder, so that the milk fat globule membrane and the casein glycomacropeptide are closer to breast milk, have antiviral and antibacterial effects, and are beneficial to improving the immunity of infants.

Description

Sialic acid-containing infant formula milk powder and preparation method thereof

Technical Field

The invention belongs to the field of food manufacturing, and particularly relates to infant formula milk powder with sialic acid and a preparation method thereof.

Background

At present, sialic acid and milk fat globule membrane protein are utilized to improve the immunity of infants, and are more and more taken into consideration by the dairy industry and even the nutritional industry. Some researches and reports have been made at home and abroad to solve the problem of the difference of the effect of formula milk powder and breast feeding from the aspect of adding beneficial immune components in the breast milk, particularly the nutritive values of the two raw materials, namely sialic acid and milk fat globule membrane, are very clear after years of research and clinical tests, and are also widely applied to various nutriments. However, both sialic acid and milk fat globule membrane are often used for preparing nutriments or health care products to improve human immunity, on the other hand, most of the currently marketed sialic acid is N-glycolylneuraminic acid (Neu5Gc), and the sialic acid in the form is inconsistent with the structure in breast milk and may not achieve the effect of improving the immunity of infants.

Although it is disclosed in the prior art that certain formulas may contain sialic acid and milk fat globule membrane protein, for example, chinese patent publication CN 111587923 a discloses an infant formula containing sialic acid and a method for preparing the same, which comprises sialic acid, milk fat globule membrane protein, human milk oligosaccharide, lactoferrin. However, this patent application contains too many active ingredients, which increases the cost and complexity of manufacture. In addition, the infant formula milk powder containing the sialic acid and the milk fat globule membrane protein only adds the two active components and does not verify the efficacy structurally, the sialic acid has two structural forms, only the sialic acid of N-acetylneuraminic acid (Neu5Ac) is consistent with the structure of the sialic acid in breast milk, and the added sialic acid is consistent with the structural form of the breast milk and has the immune efficacy.

Disclosure of Invention

The invention aims to provide infant formula milk powder, which provides sialic acid and phospholipid by containing casein glycomacropeptide and milk fat globule membrane so as to enhance the function of the milk powder to improve the immunity of infants.

According to one aspect of the present invention, there is provided an infant formula containing sialic acid, comprising 0.3-1% milk fat globule membrane, 0.1-0.5% casein glycomacropeptide, based on the total weight of the infant formula.

Preferably, the sialic acid content is 150-470mg/100g and the sphingomyelin content is 70-93mg/100 g.

Preferably, more than 99% of the sialic acids are in the form of N-acetylneuraminic acid in structure.

Preferably, the total content of protein is 10-19%, the content of fat is 17-29%, the content of dietary fiber is 0.95-1.2%, and the content of carbohydrate is 50-57% based on the total weight of the infant formula.

Preferably, the content of the whey protein in the protein is 35-70% by mass.

Preferably, the infant formula comprises the following raw materials by weight based on 1000 parts of infant formula: 3-10 parts of milk fat globule membrane; and 1-5 parts by weight of casein glycomacropeptide.

Preferably, the raw materials of the infant formula further comprise:

preferably, the raw materials of the infant formula further comprise:

preferably, the raw materials of the infant formula further comprise:

preferably, the compound nutrient comprises any one or more of the following ingredients:

a. the vitamin is compounded, and the vitamin is compounded,

b. a source of calcium in the form of a calcium source,

b. the mineral substances are compounded with the raw materials,

c. the compound is the choline chloride and the mixture is mixed,

d. compounding magnesium chloride;

e. compounding potassium chloride.

Preferably, the compound mineral comprises one or more of iron, zinc, copper, iodine, selenium and manganese, and the calcium source comprises calcium and phosphorus.

According to another aspect of the present invention, there is provided a method for preparing the above infant formula.

The infant formula milk powder contains sialic acid with a structure consistent with that of breast milk, so that the composition of the milk powder is closer to that of the breast milk, and the infant formula milk powder has the effect of improving the immunity of infants.

Detailed Description

Technical features, objects and advantages of the present invention will be more clearly understood and appreciated by those skilled in the art. It should be understood that the following detailed description is merely exemplary, and the technical solution of the present invention is not limited to the specific embodiments listed below.

The invention aims to provide the sialic acid-containing infant formula milk powder and the preparation method thereof, so that the milk powder feeding effect is closer to that of breast milk, and the immunity of infants is improved.

The invention relates to an infant formula milk powder containing sialic acid. In the milk powder, the addition amount of a milk fat globule membrane is 3-10 parts by weight and the addition amount of casein glycomacropeptide is 1-5 parts by weight based on 1000 parts by weight, wherein the effective components of the milk fat globule membrane are calculated by Sphingomyelin (SM), lecithin (PC), Phosphatidylserine (PS), Phosphatidylethanolamine (PE) and Phosphatidylinositol (PI), and the effective components of the casein glycomacropeptide are calculated by sialic acid.

The sialic acid is provided by casein glycomacropeptide and milk fat globule membrane together. Because sialic acid has two different structures, and the sialic acid contained in some raw materials is different due to different preparation processes, more than 99% of the structures of the sialic acid in the casein glycomacropeptide and the milk fat globule membrane are sialic acid consistent with the structure of breast milk, namely the form of Neu5 Ac. The casein glycomacropeptide and the milk fat globule membrane of the invention are commercially available products currently available from the alax company.

In the infant formula milk powder provided by the invention, the raw materials of total protein comprise one or more of raw milk, whole milk powder, skimmed milk powder, whey protein powder and desalted whey powder, and the infant formula milk powder further comprises: alpha-lactalbumin powder serving as a raw material added for strengthening alpha-lactalbumin and beta-casein powder serving as a raw material added for strengthening beta-casein.

In the infant formula milk powder provided by the invention, the raw materials for providing fat comprise vegetable oil and/or OPO structure fat besides the basic raw materials containing milk fat.

According to a specific embodiment of the invention, the infant formula milk powder containing sialic acid has a total protein content of 10-19 g/100g milk powder, preferably 13-17g/100g milk powder, more preferably 15g/100g milk powder, and the total protein mainly comprises milk protein. In addition, the proportion of whey protein to total protein is generally controlled to 48% to 70%. Specifically, the raw material for providing the milk protein comprises one or more of basic raw materials of milk, whole milk powder, skimmed milk powder, whey protein powder and desalted whey powder. Preferably, the infant formula milk powder containing sialic acid comprises the following raw materials in parts by weight based on 1000 parts by weight: 850-1750 parts of raw milk and 0-275 parts of skimmed milk powder. The raw milk and the skimmed milk powder can be partially or completely replaced by equivalent whole milk powder and skimmed milk.

Further, one or more of whey protein powder (such as whey protein powder WPC 80%, whey protein powder WPC 34%, etc.) and desalted whey powder (such as desalted whey powder D70, D90, etc.) added for strengthening whey protein preferably include desalted whey powder and whey protein powder (such as whey protein powder WPC 80% and/or whey protein powder WPC 34%).

Furthermore, a raw material alpha-lactalbumin powder is further added for the alpha-lactalbumin in the fortified product, and a raw material beta-casein powder is further added for the beta-casein in the fortified product. Preferably, the milk fat globule membrane and sialic acid containing breast milk emulsified infant formula is prepared from the following raw materials in parts by weight based on 1000 parts by weight of the breast milk fat globule membrane and sialic acid containing breast milk fat globule membrane and sialic acid: 0-170 parts of whey protein powder (preferably including 0-170 parts of whey protein powder WPC 34%); 25-225 parts by weight of desalted whey powder; 3-40 parts of alpha-lactalbumin powder; 0.5-25 parts of beta-casein powder.

In the sialic acid-containing infant formula of the present invention, the fat-providing raw material includes, in addition to the milk fat-containing base raw material (such as the aforementioned raw milk and skim milk powder), vegetable oil, which may include one or more of sunflower seed oil, corn oil, soybean oil, canola oil, coconut oil, palm oil, and walnut oil, and preferably includes sunflower seed oil, corn oil, and soybean oil. The addition of the vegetable oil provides fat components for the product, provides linoleic acid and can also provide alpha-linolenic acid (preferably, the content of the alpha-linolenic acid in the milk powder is 310-450 mg/100 g). In addition, the raw material for providing the fat may optionally include a raw material OPO structural fat added for providing the 1, 3-dioleoyl-2-palmitic acid triglyceride. Because the OPO structural fat raw materials sold in the market have different purities, namely the content of the 1, 3-dioleate-2-palmitic acid triglyceride serving as an active ingredient is different and is usually about 40-70%. In the present invention, in order to distinguish the effective ingredient 1, 3-dioleoyl-2-palmitic acid triglyceride and the raw material thereof, the term "1, 3-dioleoyl-2-palmitic acid triglyceride" is used in describing the effective ingredient, and a commonly known "OPO structural fat" is used in describing the food raw material that provides the effective ingredient 1, 3-dioleoyl-2-palmitic acid triglyceride. The specific addition amount of the OPO structural fat can be converted according to the content requirement of the 1, 3-dioleoyl-2-palmitic acid triglyceride in the milk powder product and the purity of the OPO structural fat raw material. More preferably, the infant formula powder containing sialic acid comprises the following raw materials by weight based on 1000 parts of infant formula powder containing sialic acid: 0-80 parts by weight of sunflower seed oil; 0-40 parts by weight of corn oil; 0-80 parts by weight of soybean oil; 0-140 parts of OPO structure grease.

Preferably, the contents of linoleic acid and alpha-linolenic acid in the sunflower seed oil, the corn oil, the soybean oil and the OPO structure fat used as the raw materials in the invention are respectively 7.6-8.9%, 0.25-0.38%, 53.0-56.20%, 0.9-1.6%, 50.0-53.5%, 7.6-9.6%, 5.9-6.3% and 0.4-0.62%, the contents of the linoleic acid and the alpha-linolenic acid used as the low erucic acid rapeseed oil are respectively 16-19%, 8.0-10.6%, and the contents of the linoleic acid and the alpha-linolenic acid used as the coconut oil are respectively 1-3% and 0-1%. The effective content of 1, 3-dioleic acid-2-palmitic acid triglyceride in the OPO structure fat raw material is 40-70%.

According to the infant formula containing sialic acid, the milk fat globule membrane and the casein glycomacropeptide are added to provide sialic acid. The sialic acid content in the milk powder is 470mg/100g of 150-663 mg/L converted into the milk liquid, preferably 350mg/100g of 190-494 mg/L converted into the milk liquid.

According to the infant formula containing sialic acid, the milk fat globule membrane added in the invention is used for providing sphingomyelin. The content of sphingomyelin in the milk powder is 30-120mg/100g of milk powder, and is 39.6-169.2mg/L in terms of milk liquid, preferably 60-98mg/100g of milk powder, and is 84.6-138.2mg/L in terms of milk liquid.

According to the infant formula milk powder containing sialic acid, the milk fat globule membrane and the casein glycomacropeptide added in the milk powder have antiviral and antibacterial effects in the application of preparing the infant milk powder for improving immunity, and are beneficial to improving the immunity of infants.

According to a specific embodiment of the invention, in the infant formula containing sialic acid, the probiotic is bifidobacterium. Preferably, the bifidobacterium is added in an amount of 0.1-0.2 parts by weight based on 1000 parts by weight of the sialic acid-containing maternal and infant formula; and more preferably 0.18 to 0.2 parts by weight. More preferably, the bifidobacterium powder contains 3 x 10 bifidobacteria per weight part¹⁰Above CFU.

According to a specific embodiment of the present invention, the sialic acid containing maternal milk infant formula of the present invention, the carbohydrate is partially derived from lactose containing basic materials such as milk, whole milk powder and/or skim milk powder, and the carbohydrate is provided by adding lactose material. That is, in the infant formula of the present invention, the raw material for providing carbohydrates includes lactose as a raw material in addition to the base material containing lactose. Preferably, the sialic acid-containing maternal emulsified infant formula comprises the following raw materials in parts by weight based on 1000 parts by weight of the maternal emulsified infant formula: 125-325 parts of lactose. The specific addition amount of the lactose can be adjusted within the range, so that the content of the carbohydrate in the maternal emulsified infant formula milk powder containing sialic acid is 52-56 g/100 g.

According to a specific embodiment of the invention, the sialic acid containing maternal emulsified infant formula of the invention further comprises one or more of proper DHA, ARA, lactoferrin and the like, further comprises compound nutrients comprising a calcium source, vitamins and minerals, and further comprises carrier anhydrous cream and phospholipids used in the preparation process of the milk powder during spray drying. Preferably, the sialic acid-containing maternal emulsified infant formula comprises the following raw materials in parts by weight based on 1000 parts by weight: 2-15 parts of DHA; 3-22 parts of ARA; 0-0.7 parts by weight of lactoferrin; 7-17 parts by weight of compound nutrients comprising a calcium source, vitamins and minerals; 1-4 parts by weight of phospholipid; 0-2 parts of anhydrous cream.

In the sialic-acid-containing maternal-emulsion infant formula milk powder, the compound nutrients are a combination of nutrient components meeting the national standard, and different addition amounts are used according to different formulas. According to the formula milk powder, any one or any combination of the following compound nutrient components can be selectively adopted if the nutrient is added according to the needs.

Preferably, the compound nutrient at least comprises compound vitamins, a calcium source and a mineral nutrition bag, and the dosage of each component is as follows:

1) the compound vitamins comprise the following components in each gram of compound vitamins:

taurine: 180-340 mg of a magnesium alloy powder,

vitamin A: 1700 to 5800 mu gRE of the glass fiber,

vitamin D: 30 to 70 mu g of a surfactant,

vitamin B1: 3600 to 6800 mu g,

vitamin B2: 3500 to 6900 mu g of the total weight of the composition,

vitamin B6: 2400-4000 mu g of a mixture of the above-mentioned components,

vitamin B12: 8-20 mu g of a surfactant,

vitamin K1: 400 to 700 mu g of a surfactant in a carrier,

vitamin C: 330-700 mg of a nitrogen-containing compound,

vitamin E: 27 to 70mg of alpha-TE,

nicotinamide: 26000 to 41550 μ g of a drug,

folic acid: 700 to 920 mu g of a surfactant,

biotin: 100 to 245 mu g of a surfactant in a carrier,

pantothenic acid: 12000 to 25230 μ g of a surfactant,

inositol: 140-250mg of the total amount of the magnesium oxide,

l-carnitine: 35-60 mg;

2) a calcium source comprising per gram of calcium source:

calcium: 300-455 mg of a magnesium alloy powder,

phosphorus: 75-150 mg;

3) the compound mineral comprises the following components in per gram of the compound mineral:

iron: 40-85 mg of a surfactant, and a carrier,

zinc: 23-48 mg of a nitrogen-containing compound,

copper: 2600 to 4180 mu g of a composition,

iodine: 500 to 995 mu g of the total weight of the composition,

selenium: 0 to 200 μ g of a surfactant,

manganese: 0 to 579 μ g;

4) the compound magnesium chloride per gram comprises the following components:

magnesium: 80-170 mg;

5) the compound potassium chloride per gram comprises the following components:

potassium: 400-580 mg;

6) compound choline chloride, wherein each gram of compound choline chloride comprises:

choline: 300-950 mg.

The base material of the compound nutrient is preferably lactose or L-sodium ascorbate. Based on 1000 parts by weight of the sialic acid-containing mother emulsion infant formula milk powder, the addition amount of compound nutrients is 7-17 parts by weight, wherein the compound vitamin nutrition package is preferably 2-4 parts by weight, the calcium source is preferably 2-12 parts by weight, the compound mineral substance is preferably 0.5-3 parts by weight, the compound magnesium chloride is 0.5-2 parts by weight, and the compound potassium chloride is 0.5-4.5 parts by weight. The base of each nutritional package is preferably lactose or sodium L-ascorbate.

The amount of the bifidobacterium added is 0.1 to 0.2 weight part.

In addition, the compound materials used to provide each nutrient in the nutrient pack may interact. For example, the sulphate salts may accelerate the action of vitaminsThe destruction process is oxidized, reducing its utilization. Since sulfate is present in the form of ions in aqueous solution, it acts as an oxidizing agent in an oxidation reaction to induce oxidation of vitamins and destroy the structure of vitamins. The trace elements have different abilities in oxidation-reduction reaction, and the activities of copper, zinc and iron are the strongest, and the activities of manganese and selenium are the second order. The B vitamins and vitamin C are susceptible to copper ion, vitamin B₂Is susceptible to iron ions.

To ensure the efficient use of nutrients, the present invention preferably selects a stable nutrient formulation, such as: the vitamin A is preferably retinyl acetate, and the retinol has 1 hydroxyl group and 5 double bonds and is very easy to oxidize, but the stability of the retinol in the form of acetate is greatly improved. Vitamin E is preferably selected from tocopherol acetate, which is also very unstable, but the stability of tocopherol acetate is much improved. Vitamin B₁Thiamine nitrate is preferably selected, which is more stable than thiamine hydrochloride in the form in which it is present. The vitamin C is preferably sodium L-ascorbate.

The content of each component of the compound nutrient is the additive amount for enhancing the nutrient substance, and does not include the content of nutrient components in other raw materials of the milk powder, for example, the content of calcium source (calcium carbonate) in the second mineral substance, and the content of "calcium: 1300-1600 g' refers to that in order to strengthen calcium element in the product, a second mineral (such as calcium carbonate) is added according to the weight of the calcium element in 1300-1600 g based on 1000kg of milk powder.

In the sialic-acid-containing breast-emulsified infant formula milk powder, the raw materials of phospholipid and anhydrous cream are mainly used for forming powder particles in a spray drying process, and the phospholipid can be soybean phospholipid and/or lecithin. The usage amount of phospholipid and anhydrous butter is less, but the phospholipid and anhydrous butter also have certain contribution to the fat content in the milk powder product.

According to a preferred embodiment of the present invention, the sialic acid containing maternal emulsion infant formula of the present invention comprises the following raw materials:

7-17 parts by weight of compound nutrients comprising a calcium source, vitamins and minerals;

2-15 parts of DHA;

3-22 parts of ARA;

0.1-0.2 weight parts of bifidobacterium.

It can be understood that in the mother emulsified infant formula milk powder containing sialic acid, the specific dosage of each raw material is determined by adjusting on the premise of meeting the index requirements of the formula milk powder product. In the mother emulsified infant formula milk powder containing sialic acid, product performance indexes which are not described or listed in detail are implemented according to the national standard of infant formula food and the regulations of related standards and regulations.

In the sialic acid-containing maternal emulsified infant formula milk powder, all raw materials can be obtained commercially, the selection of all raw materials meets the requirements of relevant standards, and the milk fat globule membrane and the casein glycomacropeptide simultaneously meet the requirements of the invention. In addition, the compound nutrient can also be compounded by itself. "compounding" is used herein for convenience only and does not mean that the components of the formulation must be mixed together prior to use. All raw materials are added and used on the premise of meeting relevant regulations.

On the other hand, the invention also provides a method for preparing the sialic acid-containing maternal emulsified infant formula, and the preparation process mainly comprises the following steps: preparing materials, homogenizing, concentrating, sterilizing, spray drying, and dry mixing to obtain the final product. Specifically, the method for preparing the sialic acid-containing maternal-emulsion infant formula comprises the following steps:

preparing materials: mixing raw milk and formula milk powder except spray carrier (phospholipid and anhydrous cream) and post-mixed material (such as DHA, ARA, lactoferrin, Bacillus bifidus, etc.) to obtain mixed material liquid;

homogenizing: homogenizing the mixed feed liquid;

concentration and sterilization: and (3) concentrating and sterilizing the homogenized feed liquid, wherein the concentrating and sterilizing conditions are as follows: double-effect concentration, wherein the sterilization temperature is more than or equal to 83 ℃, the sterilization time is 20-30 seconds, and the discharge concentration is controlled to be 48-52% of dry matter;

spray drying: preheating the concentrated milk to 60-70 ℃ by a scraper preheater, filtering the preheated material by a filter with the aperture of 0.8-1.2 mm, and then pumping the material into a drying tower for spray drying, wherein the spray drying conditions are controlled as follows: the air inlet temperature is 165-180 ℃, the air exhaust temperature is 75-90 ℃, the high-pressure pump pressure is 160-210 bar, and the tower negative pressure is-4 to-2 mbar;

drying and cooling the fluidized bed: the powder coming out of the drying tower is subjected to secondary drying by a primary fluidized bed, then is cooled to 25-30 ℃ by a secondary fluidized bed, and simultaneously, under the action of compressed air, the mixture of phospholipid (lecithin and/or soybean phospholipid) and a carrier (anhydrous cream) heated to 60-65 ℃ is uniformly dispersed on the surface of the powder to obtain powder particles;

post-mixing: mixing DHA, ARA, lactoferrin, and Bacillus bifidus with fluidized bed dried and cooled powder particles, and packaging to obtain milk powder product.

According to the embodiment of the invention, the order of dissolving the nutrients, the stirring and dissolving time and the adding time are also very important in the preparation method of the maternal emulsified infant formula containing sialic acid. In actual production, compound vitamins, compound mineral substances, a calcium source and compound choline chloride are fed in different time sequences. The vitamins and minerals have different feed ports, which can reduce the time and chance of bringing the easily reacting compounds together.

During material preparation, preferably, the dissolving sequence of each nutrient package is calcium source, compound mineral matter, compound magnesium chloride, compound potassium chloride, compound vitamin and compound choline chloride. The dissolving time of the calcium source in the calcium powder tank is 10-15 minutes. And adding the compound mineral, the compound magnesium chloride and the compound potassium chloride into a mineral tank in sequence for dissolving for 30-40 minutes. Dissolving the compound vitamin in a vitamin tank for 5-10 minutes, and dissolving the compound choline chloride in a choline tank for 5-10 minutes. Then the calcium powder tank, the vitamin tank, the choline tank and the mineral tank are sequentially pumped into a wet mixing tank of other mixed powder and oil materials according to the sequence of the nutrient tank.

The inventors have found in their studies that by adding a calcium source to the wet mix tank, calcium can combine with casein in the milk protein to form colloidal calcium, thereby avoiding or reducing the precipitation of calcium, which, however, takes a sufficient time. Meanwhile, if the calcium source is added with other minerals at the same time, the calcium source can adsorb part of the minerals such as iron to promote the minerals to change from ferrous iron to ferric iron, and the ferric iron is red, so that yellow to red precipitates are easily caused. And secondly, adding vitamins, wherein the vitamins contain components such as VC which are easily oxidized by metal ions, and if minerals are added firstly, the vitamins are lost due to overhigh local vitamin concentration. The minerals are added finally because they are dispersed in water more slowly than vitamins, and during the mineral dispersion process, a water film is formed on the surface of the particles to stabilize them and do not damage milk proteins, which takes a sufficient time. The vitamin is fully mixed with the milk and diluted, and then the mineral is added, so that the loss of the vitamin by the mineral can be reduced.

According to a specific embodiment of the present invention, in the method for preparing a sialic acid containing maternal emulsion infant formula, the compounding process comprises:

milk rough filtration: after being subjected to coarse filtration and degassing by a balance cylinder, the milk is preheated by a plate heat exchanger, and then impurities are separated by a separator.

Homogenizing and sterilizing milk: one part of the raw milk without impurities enters a homogenizer for homogenization, the other part of the raw milk is inhomogeneous, and the homogenized raw milk are mixed and enter a sterilization system for sterilization.

Adding powder: various powder raw materials are metered according to the formula, uniformly added into a powder preparation tank through an air conveying system, and sucked into a vacuum mixing tank through a vacuum system;

dissolving and oil blending: putting the grease specified in the formula into an oil dissolving chamber according to the formula requirement, keeping the temperature of the oil dissolving chamber at 50-90 ℃, pouring the oil into a mixed oil storage tank after the oil is dissolved, and pouring the mixed oil into a material mixing tank through an oil pump according to the formula requirement;

dissolving and adding nutrients: respectively dissolving calcium source, vitamins and minerals with purified water, and sequentially adding into a mixing tank to obtain mixed feed liquid.

In a specific embodiment of the present invention, the preparation method of the sialic acid containing maternal emulsified infant formula of the present invention is performed as follows:

1) adding powder: various powder raw materials are metered according to the formula and then uniformly added into a powder preparation tank through an air conveying system for storage.

2) Vacuum powder absorption: various powder raw materials in the powder mixing tank are sucked into the vacuum mixing tank through a vacuum system.

3) Dissolving and oil blending: and (3) putting the grease specified in the formula into an oil dissolving chamber according to the formula requirement, keeping the temperature of the oil dissolving chamber at 50-90 ℃, and pumping the oil into a mixed oil storage tank according to the formula proportion requirement through an oil pump and a flowmeter after the oil is dissolved.

4) And (3) mixed oil storage: and (3) storing the mixed oil in an oil storage tank in a heat-preservation way at the temperature of 40-50 ℃ for less than 12 hours to prevent fat oxidation.

5) Weighing: and pumping the mixed oil into a mixing tank through an oil pump according to the formula requirement.

6) Dissolving and adding nutrients: respectively adding a calcium source, vitamins, minerals and the like, respectively dissolving the calcium source, the vitamins, the minerals and the like with 100-200 kg of purified water, and then putting the dissolved calcium source, the vitamins, the minerals and the like into a wet mixing tank, and flushing an adding tank and a pipeline with 100kg of purified water after each time of beating.

7) And (3) filtering: filtering the mixed feed liquid by a filter screen to remove physical impurities possibly brought in the raw materials.

8) Homogenizing: homogenizing the mixed feed liquid by a homogenizer, wherein the primary pressure of the homogenization is 105 +/-5 bar, the secondary pressure of the homogenization is 32 +/-3 bar, and mechanically processing the mixture to disperse the fat globules into uniform fat globules.

9) Cooling and storing: and (3) cooling the homogenized material liquid in a plate heat exchanger to below 20 ℃, temporarily storing the material liquid in a pre-storage cylinder, entering the next procedure within 6 hours, and starting a stirrer according to a set requirement.

10) Concentration and sterilization: double-effect concentration is adopted during production, the sterilization temperature is more than or equal to 83 ℃, and the sterilization time is 25 seconds. The discharged material concentration is 48-52% dry matter.

11) Storing concentrated milk, preheating, filtering and spray drying: the concentrated milk is temporarily stored in a concentrated milk balancing tank. Preheating to 60-70 ℃ by a scraper preheater, filtering the preheated material by a filter with the aperture of 1mm, pumping the filtered material into a drying tower by a high-pressure pump for spray drying, and agglomerating fine powder at the tower top or a fluidized bed as required. Air inlet temperature: 165-180 ℃, the exhaust temperature is 75-90 ℃, the high-pressure pump pressure is 160-210 bar, and the tower negative pressure is-4 to-2 mbar.

12) Drying and cooling the fluidized bed: and (3) drying the powder discharged from the drying tower for the second time by using a fluidized bed (first stage), and cooling to 25-30 ℃ by using a fluidized bed (second stage). Meanwhile, phospholipid and a carrier are mixed and heated to 60-65 ℃, and are uniformly dispersed on the surface of the powder under the action of compressed air, so that the particle size and the instant solubility of the powder particles are increased by agglomeration.

13) Subpackaging: and (3) weighing, bagging and subpackaging DHA, ARA lactoferrin and bifidobacterium by powder making workshop personnel according to the formula requirements.

14) Dry mixing: and uniformly mixing the weighed DHA, ARA, lactoferrin, bifidobacterium and milk powder in a dry mixer.

15) Powder sieving: the granularity of the milk powder is uniform through the vibrating screen, and the powder residue is discarded.

16) Powder discharging: and (4) receiving the powder by using a sterilized powder collecting box, and conveying the powder to a powder feeding room from a powder discharging room.

17) Powdering: pouring the milk powder into a powder storage tank on a large and small packaging machine according to the packaging requirements.

18) Packaging: 400 g of the mixture is packaged by an automatic packaging machine in a nitrogen-filled mode. The oxygen content is lower than 1% when charging nitrogen. The oxygen content of the 900 g iron can in the automatic nitrogen-filled package is lower than 5 percent.

19) Boxing: and (4) filling the packaged small bags into a paper box, adding a powder spoon, and sealing by using a box sealing machine.

20) And (4) inspecting a finished product: and sampling and inspecting the packaged product according to an inspection plan.

21) And (4) warehousing and storing: and warehousing and storing the qualified product at normal temperature with the humidity less than or equal to 65 percent.

Compared with the prior art, the invention has the following advantages:

the milk powder is added with the milk fat globule membrane and the casein glycomacropeptide, is more similar to breast milk, plays a role in resisting virus and bacteria, and is beneficial to improving the immunity of infants.

In conclusion, the milk powder provided by the invention is added with the milk fat globule membrane and the casein glycomacropeptide, is closer to breast milk, plays a role in resisting virus and bacteria, and is beneficial to improvement of the immunity of infants.

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments.

The methods used in the following examples are conventional methods unless otherwise specified, and the reagents used are commercially available reagents unless otherwise specified.

Example 1

Breast milk infant formula containing sialic acid (1000 kg prepared):

1000kg of raw milk, 300 kg of lactose, 40kg of whey protein powder WPC 80%, 90175 kg of desalted whey powder D, 30kg of sunflower seed oil, 20kg of corn oil, 65 kg of soybean oil, 110 kg of OPO structural fat, 27 kg of alpha-whey protein powder, 9kg of beta-casein powder, 2kg of lecithin, 1kg of anhydrous cream, 17kg of fructo-oligosaccharide powder, 40kg of galacto-oligosaccharide syrup, 5kg of milk fat globule membrane, 1kg of casein glycomacropeptide, 16 kg of compound nutrient, 8 kg of DHA, 8 kg of ARA and 0.2kg of bifidobacterium.

The compound nutrients comprise a compound vitamin nutrient bag of about 2.5kg, a choline chloride nutrient bag of about 0.75kg, a calcium source nutrient bag of about 6kg, a mineral nutrient bag of about 1kg and a magnesium chloride and potassium chloride nutrient bag, wherein the base material of each nutrient bag is lactose, and the specific main nutrients comprise the following components: 1) compounding vitamins, wherein in each gram of the compounding vitamins, taurine: 180 mg; vitamin a (retinyl acetate): 2300 μ gRE; vitamin D (cholecalciferol): 34 mu g of the total weight of the mixture; vitamin B1 (thiamine nitrate): 4000 microgram; vitamin B2 (riboflavin): 1200 mug; vitamin B6 (pyridoxine hydrochloride): 2050 μ g; vitamin B12 (cyanocobalamin): 11.2 mu g; vitamin K1 (phytomenadione): 400 mu g; vitamin C (L-ascorbic acid): 495 mg; vitamin E (dl- α -tocopheryl acetate): 38mg of alpha-TE; nicotinamide: 23050 μ g; folic acid: 530 μ g; biotin (D-biotin): 88 mu g of the total weight of the mixture; pantothenic acid (calcium D-pantothenate): 15000 mu g; 2) calcium source, calcium (calcium carbonate, tricalcium phosphate) per gram of calcium source: 230 mg; phosphorus (tricalcium phosphate): 90 mg; 3) minerals, per gram of mineral, iron (ferrous sulfate): 80 mg; zinc (zinc sulfate): 45 mg; copper (copper sulfate): 4000 microgram; iodine (potassium iodide): 980 ug; selenium (sodium selenite): 170 mu g of the mixture; manganese (manganese sulfate): 550 mu g of the solution; 4) magnesium chloride, per 1000kg of milk powder, magnesium (magnesium chloride): 150g of the total weight of the mixture; 5) potassium chloride, per 1000kg of milk powder, potassium (potassium chloride): 1050g of the total weight of the mixture; 6) choline chloride, per 1000kg of milk powder, choline (choline chloride): 700 g.

Wherein the contents of linoleic acid and alpha-linolenic acid in the used raw materials of high oleic acid sunflower seed oil, corn oil, soybean oil and structured oil (OPO) are respectively 8.20%, 0.3%, 55.50%, 1.2%, 52.10%, 8.8%, 6.18% and 0.47%.

The sialic acid content of the product is 192mg/100g powder, which is converted into 253mg/L milk, and the sphingomyelin content is 74.5mg/100g powder, which is converted into 98.3mg/L milk.

The preparation process of the sialic acid-containing breast milk infant formula milk powder comprises the following steps:

3) Dissolving and oil blending: the grease specified in the formula is put into the oil-dissolving room according to the formula requirement, the temperature of the oil-dissolving room is kept at 60 ℃, and after the oil is dissolved, the oil is pumped into a mixed oil storage tank through an oil pump and a flowmeter according to the formula proportion requirement.

4) Weighing: and pumping the mixed oil into a mixing tank through an oil pump according to the formula requirement.

5) Dissolving and adding nutrients: respectively adding calcium source, vitamins, minerals, etc., dissolving with 150kg purified water, and filling into a mixing tank, wherein after each time one is beaten, the adding tank and the pipeline are flushed with 100kg purified water.

6) And (3) filtering: filtering the mixed feed liquid by a filter screen to remove physical impurities possibly brought in the raw materials.

7) Homogenizing: homogenizing the mixed material liquid by a homogenizer, mechanically processing the fat balls, and dispersing the fat balls into uniform fat balls.

8) Cooling and storing: and (3) feeding the homogenized material liquid into a plate heat exchanger for cooling: cooling to below 20 ℃, temporarily storing in a pre-storage cylinder, entering the next procedure within 6 hours, and starting the stirrer according to the set requirement.

9) Concentration and sterilization: double-effect concentration is adopted during production, the sterilization temperature is more than or equal to 83 ℃, and the sterilization time is 25 seconds. The discharge concentration was 50% dry matter.

10) Storing concentrated milk, preheating, filtering and spray drying: the concentrated milk is temporarily stored in a concentrated milk balancing tank. Preheating to 60 deg.C with a scraper preheater, filtering the preheated material with a filter with 1mm pore diameter, pumping into a drying tower with a high pressure pump, spray drying, and agglomerating fine powder at the tower top or fluidized bed as required. Air inlet temperature: 180 ℃, the exhaust temperature is 86 ℃, the pressure of the high-pressure pump is 200bar, and the negative pressure of the tower is about-4 mba.

11) Drying and cooling the fluidized bed: the powder from the drying tower is dried for the second time by the fluidized bed (first stage) and then cooled to 30 ℃ by the fluidized bed (second stage). Meanwhile, lecithin and a carrier are mixed and heated to 60 ℃, and the mixture is uniformly dispersed on the surface of the powder under the action of compressed air, so that the particle size and the instant solubility of the powder are increased by agglomeration of the powder particles.

12) Subpackaging: and (3) weighing DHA, ARA or bifidobacterium, sealing bags and subpackaging by powder-making workshop personnel according to the formula requirements.

13) Dry mixing: and uniformly mixing the weighed DHA, ARA or bifidobacteria with the milk powder in a dry mixer.

14) Powder sieving: the granularity of the milk powder is uniform through the vibrating screen, and the powder residue is discarded.

15) Powder discharging: and (4) receiving the powder by using a sterilized powder collecting box, and conveying the powder to a powder feeding room from a powder discharging room.

16) Powdering: pouring the milk powder into a powder storage tank on a large and small packaging machine according to the packaging requirements.

17) Packaging: 400 g of the mixture is packaged by an automatic packaging machine in a nitrogen-filled mode. The oxygen content is lower than 1% when charging nitrogen. The oxygen content of the 900 g iron can in the automatic nitrogen-filled package is lower than 5 percent.

18) Boxing: and (4) filling the packaged small bags into a paper box, adding a powder spoon, and sealing by using a box sealing machine.

19) And (4) inspecting a finished product: and sampling and inspecting the packaged product according to an inspection plan.

20) And (4) warehousing and storing: and warehousing and storing the qualified product at normal temperature with the humidity less than or equal to 65 percent.

Example 2

Breast milk infant formula containing sialic acid (1000 kg prepared):

1200 kg of raw milk, 140 kg of lactose, 100kg of whole milk powder, 260 kg of skim milk powder, 100kg of whey protein powder WPC 34%, 100kg of desalted whey powder D90210 kg, 22 kg of sunflower seed oil, 15kg of corn oil, 48 kg of soybean oil, 85 kg of OPO structure fat, 4 kg of alpha-lactalbumin powder, 1kg of beta-casein powder, 2kg of soybean lecithin, 1kg of anhydrous cream, 5kg of fructo-oligosaccharide powder, 13 kg of galacto-oligosaccharide syrup, 4 kg of milk fat globule membrane, 2kg of casein glycomacropeptide, 10.3 kg of compound nutrient, 7kg of DHA, 8 kg of ARA and 0.18 kg of bifidobacterium.

The compound nutrients comprise a compound vitamin nutrient bag of about 2.6 kg, a choline chloride nutrient bag of about 0.35 kg, a calcium source nutrient bag of about 3.7 kg, a mineral nutrient bag of about 1.3 kg and a magnesium chloride and potassium chloride nutrient bag, wherein the base material of each nutrient bag is lactose, and the specific main nutrients comprise the following components: 1) compounding vitamins, wherein in each gram of the compounding vitamins, taurine: 190 mg; vitamin a (retinyl acetate): 2000. mu.gRE; vitamin D (cholecalciferol): 40 mu g of the mixture; vitamin B1 (thiamine nitrate): 3900 μ g; vitamin B2 (riboflavin): 1000 μ g; vitamin B6 (pyridoxine hydrochloride): 1500 ug; vitamin B12 (cyanocobalamin): 5 mu g of the solution; vitamin K1 (phytomenadione): 350 mu g; vitamin C (L-ascorbic acid): 400 mg; vitamin E (dl- α -tocopheryl acetate): 30mg of alpha-TE; nicotinamide: 23000 μ g; folic acid: 420 mu g of the total weight of the mixture; biotin (D-biotin): 70 mu g of the solution; pantothenic acid (calcium D-pantothenate): 8000 mug; 2) calcium source, calcium (calcium carbonate, tricalcium phosphate) per gram of calcium source: 250 mg; phosphorus (tricalcium phosphate): 75 mg; 3) minerals, per gram of mineral, iron (ferrous sulfate): 76 mg; zinc (zinc sulfate): 26 mg; copper (copper sulfate): 2700 ug; iodine (potassium iodide): 600 mu g; selenium (sodium selenite): 160 mu g; 4) magnesium chloride, per 1000kg of milk powder, magnesium (magnesium chloride): 85 g; 5) potassium chloride, per 1000kg of milk powder, potassium (potassium chloride): 1000 g; 6) choline chloride, per 1000kg of milk powder, choline (choline chloride): 700 g.

Wherein the contents of linoleic acid and alpha-linolenic acid in the sunflower seed oil, corn oil, soybean oil and structured oil (OPO) are respectively 8.20%, 0.3%, 55.50%, 1.2%, 52.10%, 8.8%, 6.18% and 0.47%.

The sialic acid content of the product is 210.3mg/100g powder, which is 296.5mg/L converted into milk, and the sphingomyelin content is 61.6mg/100g powder, which is 86.9mg/L converted into milk.

The preparation process of the sialic acid containing breast milk infant formula powder comprises the following steps:

11) Drying and cooling the fluidized bed: the powder from the drying tower is dried for the second time by the fluidized bed (first stage) and then cooled to 30 ℃ by the fluidized bed (second stage). Meanwhile, the soybean lecithin and the carrier are mixed and heated to 60 ℃, and are uniformly dispersed on the surface of the powder under the action of compressed air, so that the particle size and the instant solubility of the powder are increased by agglomeration.

Example 3

Breast milk infant formula containing sialic acid (1000 kg prepared):

1200 kg of raw milk, 325kg of lactose, 30kg of whey protein powder WPC 34%, 90150 kg of desalted whey powder D, 40kg of sunflower seed oil, 30kg of corn oil, 45kg of soybean oil, 120kg of OPO structural fat, 25kg of alpha-whey protein powder, 10kg of beta-casein powder, 2kg of lecithin, 1kg of anhydrous cream, 15kg of fructo-oligosaccharide powder, 38 kg of galacto-oligosaccharide syrup, 9kg of milk fat globule membrane, 4 kg of casein glycomacropeptide, 16 kg of compound nutrients DHA, 12 kg of DHA, 15kg of ARA and 0.2kg of bifidobacterium.

The sialic acid content of the product is 462mg/100g powder, which is converted into 609.8mg/L milk liquid, the sphingomyelin content is 105.2mg/100g powder, which is converted into 138.9mg/L milk liquid.

Comparative example 1

Ordinary milk powder:

plain infant formula composition (1000 kg prepared):

900kg of milk, 325kg of lactose, 40kg of WPC 80%, 40kg of desalted whey powder D90225 kg, 40kg of sunflower seed oil, 30kg of corn oil, 45kg of soybean oil, 120kg of OPO structural fat, 25kg of alpha-whey protein powder, 10kg of beta-casein powder, 2kg of lecithin, 1kg of anhydrous cream, 17kg of fructo-oligosaccharide powder, 40kg of galacto-oligosaccharide syrup, 15kg of compound nutrient, 7kg of DHA, 9kg of ARA and 0.2kg of bifidobacterium.

The compound nutrient comprises about 2.5kg of compound vitamin nutrient package, about 0.75kg of choline chloride nutrient package, about 6kg of calcium source nutrient package, about 1kg of mineral nutrient package and magnesium chloride and potassium chloride nutrient package, wherein the base material of each nutrient package is lactose, and the specific main nutrients comprise the following components: 1) compounding vitamins, wherein in each gram of the compounding vitamins, taurine: 180 mg; vitamin a (retinyl acetate): 2300 μ gRE; vitamin D (cholecalciferol): 34 mu g of the total weight of the mixture; vitamin B1 (thiamine nitrate): 4000 microgram; vitamin B2 (riboflavin): 1200 mug; vitamin B6 (pyridoxine hydrochloride): 2050 μ g; vitamin B12 (cyanocobalamin): 11.2 mu g; vitamin K1 (phytomenadione): 400 mu g; vitamin C (L-ascorbic acid): 495 mg; vitamin E (dl- α -tocopheryl acetate): 38mg of alpha-TE; nicotinamide: 23050 μ g; folic acid: 530 μ g; biotin (D-biotin): 88 mu g of the total weight of the mixture; pantothenic acid (calcium D-pantothenate): 15000 mu g; 2) calcium source, calcium (calcium carbonate, tricalcium phosphate) per gram of calcium source: 230 mg; phosphorus (tricalcium phosphate): 90 mg; 3) minerals, per gram of mineral, iron (ferrous sulfate): 80 mg; zinc (zinc sulfate): 45 mg; copper (copper sulfate): 4000 microgram; iodine (potassium iodide): 980 ug; selenium (sodium selenite): 170 mu g of the mixture; manganese (manganese sulfate): 550 mu g of the solution; 4) magnesium chloride, per 1000kg of milk powder, magnesium (magnesium chloride): 150g of the total weight of the mixture; 5) potassium chloride, per 1000kg of milk powder, potassium (potassium chloride): 1050g of the total weight of the mixture; 6) choline chloride, per 1000kg of milk powder, choline (choline chloride): 700 g.

Comparative example 2

Comparative verification was made for different addition sequences of the ingredients according to the ingredients shown in the table below (not shown ingredients identical to example 1). The specific process comprises the steps of using the same formula, the same batch of raw materials and the same process parameters, then adopting 3 different nutrient adding sequences, respectively detecting the content of each nutrient in the formula milk powder produced by the different adding sequences, and comparing the loss rate of the nutrient in the process. The No. 1 is that the calcium powder tank and the mineral substance tank are pumped and added at the same time, the No. 2 is that the vitamin tank and the mineral substance tank are pumped and added at the same time, the No. 3 is that the samples are pumped and added sequentially according to the method of the invention, and the detection results of the samples produced by different adding processes are detailed in the following table:

as can be seen from the above table, the loss rate of 3# is the lowest, the loss rate of vitamin in 2# is the highest, especially the loss rate of vitamin C, the loss rate of iron is not greatly affected by 3 types of addition processes, but part of divalent iron is oxidized into ferric iron by the 1# addition process, the color of the 1# feed liquid is darker and yellowish when the nutrients are pumped, which is caused by the oxidation of divalent iron into ferric iron in minerals, but the color of milk powder is not different, because the ferrous sulfate compound is less added relative to other raw materials, the color of the product is not affected even if oxidation occurs, the detection of data is not affected, but ferric iron is less absorbed than divalent iron, and the supplement of baby iron is affected.

Comparative test

The inventor carries out consumer research activities, and selects 30 and 60 infants fed with pure breast milk and pure formula milk powder respectively in a company, wherein the infants fed with breast milk and the infants fed with formula milk powder are 0-12 months old and are healthy babies born in full term. The present inventors divided the formula-fed infants into two groups in a random, double-blind manner, and administered ordinary infant milk powder (prepared in comparative example 1) and the sialic acid-containing infant formula of the present invention (prepared in example 3) to the group infants, respectively, and followed the feeding and growth development of the 3 groups of infants every week. The infants in the pure breast feeding group are used as the growth and development indexes as the reference standard.

Examination of physical development of infants

The weight and the length of the baby in 3 months, 6 months and 12 months are detected, the program is measured by a special intelligent baby scale provided by the guardian, and the intelligent baby scale is as follows: 50kg, minimum range: 20g, precision 5 g. Body length measurement range: 40cm-80cm, and the measurement precision is 0.1 cm.

3 group infants were scored for length and weight for 3 months, wherein weight measurements were performed in the bare state, with 2 decimal points remaining; height is measured from heel to vertex in lateral recumbent position, BMI indexes (3 months, 6 months and 12 months) of two groups of infants are compared and analyzed, and the BMI index is calculated according to the following formula: weight/length²。

BMI index: the BMI index of the infants at 3 months, 6 months and 12 months of birth is obviously lower (P is less than 0.05) compared with the control group. See table 1.

TABLE 1 comparison of BMI indices (kg/m) at 3, 6 and 12 months of birth for two groups of infants²，X±S)

Group of	Number of people	3 months after birth	At 6 months of birth	At the time of birth of 12 months
					Breast milk group	30	16.61±1.39	17.55±1.55	18.73±1.84
The invention is a formula group	30	16.78±1.42	17.87±1.46	17.36±1.80
					t	/	0.379	1.947	0.403
p	/	＞0.05	＞0.05	＞0.05

The BMI indexes of the infants fed with the group of the invention at 3 months, 6 months and 12 months of birth have no statistical significance compared with the BMI index of the breast milk group (P is more than 0.05).

TABLE 2 comparison of BMI index (kg/m) at 3, 6 and 12 months of birth for infants in two groups²，X±S)

Group of	Number of people	3 months after birth	At 6 months of birth	At the time of birth of 12 months
					General formula group	30	18.23±1.05	18.64±1.22	17.17±1.56
Invention formula set	30	16.78±1.42	17.87±1.46	17.36±1.80
					t	/	0.389	1.697	0.530
p	/	＜0.05	＜0.05	＜0.05

The BMI index of infants fed the general formula group at 3, 6 and 12 months of birth were statistically different (mean P > 0.05) compared to the group of the present invention.

2.2 prevalence of three months

The guardian records the times and the number of the infants suffering from respiratory diseases, intestinal diseases and influenza diseases within 12 months, and inspects the inhibiting effect of the novel formula milk powder on the common diseases of the infants through the morbidity of 12 months.

TABLE 3 statistical Table of the disease status of infants in different feeding groups during the experiment

In view of the experimental results, the casein glycomacropeptide and the milk fat globule membrane which are simultaneously added into the infant formula milk powder have a synergistic effect on providing the immune effect of infants, so that the infant formula milk powder not only can relieve the sick symptoms of infants, but also can play a positive role in preventing the infants from getting sick.

In the comparison with the experiment that the period of breast milk is 12 months, the infant feeding growth rate of the milk powder containing sialic acid is very similar to the breast feeding effect, and is superior to the common infant formula milk powder.

The foregoing is only a preferred embodiment of the present invention. It will be appreciated that various modifications, combinations, alterations, and substitutions of the details and features of the invention may be made by those skilled in the art without departing from the spirit and nature of the invention. Such modifications, combinations, alterations and substitutions are also to be understood as being included within the scope of the invention as claimed.

Claims

1. An infant formula containing sialic acid, characterized in that it contains 0.3-1% milk fat globule membrane, 0.1-0.5% casein glycomacropeptide, based on the total weight of the infant formula.

2. The infant formula of claim 1, wherein the milk powder contains sialic acid in an amount of about 150-470mg/100g and sphingomyelin in an amount of about 30-120mg/100 g.

3. The infant formula of claim 2 wherein 99% or more of the sialic acids are in the form of N-acetylneuraminic acid.

4. The infant formula of claim 1, wherein the total amount of protein is 10-19%, the amount of fat is 17-29%, the amount of dietary fiber is 0.95-3.5%, and the amount of carbohydrate is 50-57%, based on the total weight of the infant formula.

5. The infant formula of claim 4, wherein the whey protein content of the protein is 35-70% by weight.

6. The infant formula of claim 1, wherein the raw materials comprise, based on 1000 parts by weight of the infant formula: 3-10 parts of milk fat globule membrane; and 1-5 parts by weight of casein glycomacropeptide.

7. The infant formula of claim 6, further comprising, based on 1000 parts by weight of said infant formula:

8. the infant formula of claim 6, further comprising, based on 1000 parts by weight of said infant formula:

9. the infant formula of claim 6, further comprising, based on 1000 parts by weight of said infant formula:

10. the infant formula of claim 9, wherein the built nutrient comprises any one or more of the following:

a. compounding vitamins;

b. a source of calcium in the form of a calcium source,

c. compounding minerals;

d. compounding choline chloride;

e. compounding magnesium chloride;

f. compounding potassium chloride.

11. The infant formula of claim 10, wherein the formulated minerals comprise one or more of iron, zinc, copper, iodine, selenium, and manganese, and the calcium source comprises calcium and phosphorus.

12. The method for the preparation of an infant formula according to any one of claims 1 to 11, comprising:

mixing raw milk and other raw materials including milk fat globule membrane and casein glycomacropeptide except spraying carrier phospholipid, anhydrous cream and post-mixed materials to obtain mixed feed liquid; and

adding compound nutrients into the mixed feed liquid;

wherein, the added compound nutrients comprise:

respectively dissolving a calcium source, compound vitamins, compound minerals and optionally one or more selected from compound magnesium chloride, compound potassium chloride and compound choline chloride to form a solution;

and sequentially adding a calcium source solution, a compound mineral solution, an optional compound magnesium chloride solution, an optional compound potassium chloride solution, a compound vitamin solution and an optional compound choline chloride solution into the mixed material liquid, and flushing pipelines with purified water respectively after adding the two solutions.